274 results match your criteria Breast cancer Dove Medical Press[Journal]


Nanosomal Docetaxel Lipid Suspension-Based Chemotherapy in Breast Cancer: Results from a Multicenter Retrospective Study.

Breast Cancer (Dove Med Press) 2020 22;12:77-85. Epub 2020 May 22.

Jina Pharmaceuticals Inc., Libertyville, Illinois, USA.

Purpose: The purpose of this study was to evaluate the efficacy and safety of nanosomal docetaxel lipid suspension (NDLS, DoceAqualip)-based chemotherapy in breast cancer.

Methods: Medical charts of patients with breast cancer, who were treated and followed up with NDLS (75-100 mg/m; 3-week cycle)-based chemotherapy from August 2014 to September 2018, were analyzed in this multicenter, retrospective study. The study endpoints were overall response rate (ORR: complete response [CR]+partial response [PR]) and disease control rate (DCR: CR+PR+stable disease [SD]) in neoadjuvant and metastatic settings. Read More

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http://dx.doi.org/10.2147/BCTT.S236108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250303PMC

Evaluating Nelipepimut-S in the Treatment of Breast Cancer: A Short Report on the Emerging Data.

Breast Cancer (Dove Med Press) 2020 3;12:69-75. Epub 2020 Apr 3.

University of Virginia, Department of Surgery, Charlottesville, VA 22908, USA.

Vaccine therapies for treatment and prevention of cancer have seen modest degrees of efficacy with wide variation related to the tumor type, vaccine type, adjuvants and clinical setting for their study. Over the course of the last two decades, various peptide vaccines for breast cancer have been studied. The current leading peptide vaccine for human application is a HER2-based vaccine known as Nelipepimut-S, which has demonstrated immune activity and promising clinical activity in some settings. Read More

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http://dx.doi.org/10.2147/BCTT.S224758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138626PMC

Tumor-Draining Lymph Secretome En Route to the Regional Lymph Node in Breast Cancer Metastasis.

Breast Cancer (Dove Med Press) 2020 25;12:57-67. Epub 2020 Mar 25.

Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA 20110, USA.

Background: During metastasis, tumor cells metastasize from primary tumors to distant organs via the circulatory and the lymphatic systems. There is a plethora of information about metastasis through the circulatory system, however not much information is available about the tumor cells dissemination through the lymphatic system or the lymphatic microenvironment that aids in this process in breast cancer metastasis.

Purpose: The study designed to examine the tumor-derived secretome in lymph before reaching the draining lymph nodes. Read More

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http://dx.doi.org/10.2147/BCTT.S236168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104086PMC

Fulvestrant in Combination with CDK4/6 Inhibitors for HER2- Metastatic Breast Cancers: Current Perspectives.

Breast Cancer (Dove Med Press) 2020 18;12:45-56. Epub 2020 Mar 18.

Division of Medical Senology, European Institute of Oncology, IRCCS, Milano 20141, Italy.

The development of CDK 4/6 inhibitors has dramatically changed the therapeutic management of hormone receptor-positive (HR+) and HER2 negative metastatic breast cancer (MBC). In combination with fulvestrant, palbociclib, ribociclib and abemaciclib have each been approved for HR+/HER2- MBC following the results of randomized Phase III studies (PALOMA-3, MONALEESA-3, MONARCH-2) and shown a significant advantage in PFS. Data from clinical trials support the combination with aromatase inhibitors in the first line setting and with fulvestrant in the second line. Read More

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http://dx.doi.org/10.2147/BCTT.S196240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090187PMC

Outcomes of Sentinel Lymph Node Biopsy Using Blue Dye Method for Early Breast Cancer - A Single-Institution Experience in the Philippines.

Breast Cancer (Dove Med Press) 2020 11;12:37-44. Epub 2020 Mar 11.

Department of Surgery, Cebu Doctors' University Hospital, Cebu City, Cebu, Philippines.

Purpose: This study aimed to share our experience with SLNB in the Filipino population with early breast cancer.

Patients And Methods: A retrospective review was done on all patients with confirmed invasive breast carcinoma, tumor size of 5 cm or less (T1/T2), who preoperatively had no clinical signs of axillary metastasis and subsequently underwent SLNB with blue dye method from January 01, 2008 to December 31, 2017. Clinicopathologic profiles were recorded. Read More

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http://dx.doi.org/10.2147/BCTT.S242115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073425PMC

Effect of Clinical and Treatment Factors on Survival Outcomes of Triple Negative Breast Cancer Patients.

Breast Cancer (Dove Med Press) 2020 6;12:27-35. Epub 2020 Mar 6.

Department of Radiation Oncology, Mid North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia.

Purpose: Triple negative breast cancer (TNBC) accounts for approximately 15% of breast cancer cases and is associated with a poor prognosis. In this retrospective study of patients undergoing radiation therapy as part of their treatment, disease-free survival (DFS) and overall survival (OS) of TNBC patients were examined in relation to clinical and treatment-related factors.

Patients And Methods: The electronic records of 214 consecutive TNBC patients treated with surgery followed by radiotherapy at the Mid North Coast Cancer Institute between 2006 and 2016 were reviewed. Read More

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http://dx.doi.org/10.2147/BCTT.S236483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064282PMC

Coping Assessment Tools in the Family Caregivers of Patients with Breast Cancer: A Systematic Review.

Breast Cancer (Dove Med Press) 2020 5;12:11-26. Epub 2020 Feb 5.

Department of Biostatistics, School of Public Health, Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Breast cancer is a problem that affects not only the individual's health and quality of life, but also the functionality of the family system. Caregivers experience stress when their patients cannot cope with the symptoms of their disease. The stress experienced by caregivers gives rise to psychological and physical symptoms in them. Read More

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http://dx.doi.org/10.2147/BCTT.S240928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008175PMC
February 2020

Breast Self-Examination Practice and Associated Factors Among Secondary School Female Teachers in Gammo Gofa Zone, Southern, Ethiopia.

Breast Cancer (Dove Med Press) 2020 29;12:1-10. Epub 2020 Jan 29.

Population and Family Health, Jimma University, Jimma, Oromia, Ethiopia.

Introduction: Nowadays, breast self-examination (BSE) is a breast cancer screening method that identifies breast mass by the woman herself. However, it is not widely practiced due to various problems. This study aimed to assess the magnitude of BSE practice and associated factors among female secondary school teachers in Gammo Gofa Zone, South Ethiopia. Read More

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http://dx.doi.org/10.2147/BCTT.S232021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996229PMC
January 2020

Immunotherapy for the Treatment of Breast Cancer: Emerging New Data.

Breast Cancer (Dove Med Press) 2019 31;11:321-328. Epub 2019 Dec 31.

Science Department, Arizona State University, Tempe, AZ, USA.

Breast cancer is the most common type of cancer affecting women in the United States. Triple-negative breast cancer remains the most aggressive molecular subtype secondary to a lack of therapeutic targets. The search for a target has led us to investigate immunotherapeutic agents. Read More

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http://dx.doi.org/10.2147/BCTT.S184710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997226PMC
December 2019

Hormone Therapy and Factors Affecting Fertility of Women Under 50-Year-Old with Breast Cancer.

Breast Cancer (Dove Med Press) 2019 27;11:309-319. Epub 2019 Dec 27.

School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Background: Although the use of contraceptive hormones is a risk factor for development of breast cancer, level of risk is unknown; thus the current research was conducted to investigate the effect of factors related to fertility and hormone use on risk of breast cancer in women aged under 50 years old in the west of Iran.

Methods: In this case-control study, all incidence cases of breast cancer aged between 25-49 years old (n=212) were selected. Twice as many as the case group, the individuals referred to other outpatient sections of the same hospital at the time of study and up to 2 years after the follow-up not diagnosed with breast or other cancers were selected as a control group. Read More

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http://dx.doi.org/10.2147/BCTT.S218394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938198PMC
December 2019

Chloroquine sensitizes MDA-MB-231 cells to osimertinib through autophagy-apoptosis crosstalk pathway.

Breast Cancer (Dove Med Press) 2019 23;11:231-241. Epub 2019 Jul 23.

Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL, USA.

Triple-negative breast cancer (TNBC) is a breast cancer that tests negative for estrogen receptor (ER), progesterone receptors, and human epidermal growth factor receptors 2 (HER2). It is aggressive and invasive in nature and lacks targeted therapy. The EGFR is frequently overexpressed in TNBC, and the EGFR-overexpressing TNBC presumably escapes EGFR inhibitor therapy by upregulating autophagy and inhibiting apoptosis. Read More

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http://dx.doi.org/10.2147/BCTT.S211030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664863PMC

Comparison Of Accelerated Partial Breast Radiation Therapy And External Beam Radiation Therapy By Treatment Planning Indices.

Breast Cancer (Dove Med Press) 2019 14;11:303-307. Epub 2019 Nov 14.

Department of Biochemistry and Medical Physics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.

Background: Accelerated partial breast irradiation (APBI) is a method in which just bed of lumpectomy with a margin of 1-2 cm is irradiated. Regarding advantages of APBI to whole-brain radiation therapy (WBRT) and limitations for performing other techniques, we compare external beam radiation therapy (EBRT) with three-dimensional conformal radiation therapy (3DCRT), as a type of APBI technique.

Methods: Dosimetric parameters including uniformity index (UI), conformity index (CI), and homogeneity index (HI) beside heart and lung doses were assessed and compared in two techniques. Read More

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http://dx.doi.org/10.2147/BCTT.S227686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6861531PMC
November 2019

Plasma Level Of miR-21 And miR-451 In Primary And Recurrent Breast Cancer Patients.

Breast Cancer (Dove Med Press) 2019 25;11:293-301. Epub 2019 Oct 25.

Department of Hematology and Oncology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose: MiR-21 and miR-451 are closely associated with tumor initiation, drug resistance, and recurrence of breast cancer (BC). This study was conducted to evaluate the possible value of the plasma level of miR-21 and miR-451 as potential biomarkers for the detection of primary and recurrent BC.

Patients And Methods: In this descriptive-analytical study, the plasma level of miR-21 and miR-451 was measured in 23 primary BC patients, 24 recurrent (local/distant metastasis) BC patients, and 24 aged-match women as healthy controls using quantitative reverse transcription-polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.2147/BCTT.S224333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818541PMC
October 2019

Cryoablation In The Management Of Breast Cancer: Evidence To Date.

Breast Cancer (Dove Med Press) 2019 10;11:283-292. Epub 2019 Oct 10.

Unit of General Surgery 2 - Clinica Chirurgica, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.

Cryoablation has been successfully used to treat various type of solid tumors, including breast carcinomas. This ablation method has the advantage of being a minimally invasive procedure useful in various clinical situations, including early breast cancer and metastatic breast cancer, when co-morbidities preclude the use of surgical treatment. However, due to the small sample size of the available studies, reliable and definitive conclusions on the usefulness of cryoablation in patients with breast cancer could not be drawn. Read More

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http://dx.doi.org/10.2147/BCTT.S197406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6791835PMC
October 2019

Effect of glutaminase inhibition on cancer-induced bone pain.

Breast Cancer (Dove Med Press) 2019 11;11:273-282. Epub 2019 Sep 11.

Department of Pathology and Molecular Medicine, Mcmaster University, Hamilton, ON, Canada.

Purpose: The complex nature of cancer-induced bone pain (CIBP) has led to investigation into cancer-targeted therapies. This has involved targeting glutamate release from the tumor, secreted as a byproduct of antioxidant responses and metabolic disruption. Cancer cells undergo many metabolic changes that result in increased glutamine metabolism and subsequently the production of glutamate. Read More

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http://dx.doi.org/10.2147/BCTT.S215655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6750878PMC
September 2019
2 Reads

APR-246 alone and in combination with a phosphatidylserine-targeting antibody inhibits lung metastasis of human triple-negative breast cancer cells in nude mice.

Breast Cancer (Dove Med Press) 2019 31;11:249-259. Epub 2019 Jul 31.

Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA.

Background: Approximately 15-20% of all human breast cancers are classified as triple-negative because they lack estrogen and progesterone receptors and Her-2-neu, which are commonly targeted by chemotherapeutic drugs. New treatment strategies are therefore urgently needed to combat triple-negative breast cancers (TNBCs). Almost 80% of the triple-negative tumors express mutant p53 (mtp5), a functionally defective tumor suppressor protein. Read More

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http://dx.doi.org/10.2147/BCTT.S208706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681124PMC
July 2019
2 Reads

Mammographic density parameters and breast cancer tumor characteristics among postmenopausal women.

Breast Cancer (Dove Med Press) 2019 16;11:261-271. Epub 2019 Aug 16.

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Purpose: Mammographic density is an important breast cancer risk factor, although it is not clear whether the association differs across breast cancer tumor subtypes. We examined the association between indicators of mammographic density and breast cancer risk by tumor subtype among postmenopausal women by investigating heterogeneity across tumor characteristics.

Methods: Mammographic density measures were determined for 477 breast cancer cases and 588 controls, all postmenopausal, in Vancouver, British Columbia, using digitized screening mammograms and Cumulus software. Read More

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http://dx.doi.org/10.2147/BCTT.S192766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702445PMC
August 2019
4 Reads

Positive margins (R1) risk factors in breast cancer conservative surgery.

Breast Cancer (Dove Med Press) 2019 26;11:243-248. Epub 2019 Jul 26.

Breast Surgery, Università La Sapienza, Ospedale Sant'Andrea, Rome, Italy.

Background: The primary goal in conservative breast cancer surgery is the complete excision of the tumor, but at the same time attempting to obtain a satisfactory postoperative esthetic result. The notion of "No Ink on Tumor" that indicates exclusively the presence of tumor cells on the inked surface of the surgical specimen is now the gold standard; however, the problem of the free margin is still a fundamental topic of debate that has not yet found a definitive solution.

Methods: Our retrospective analysis takes into account 1440 patients undergoing breast conservative surgery, from October 2004 to November 2018, all treated at the breast unit of our institution. Read More

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http://dx.doi.org/10.2147/BCTT.S210788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668245PMC
July 2019
1 Read

Beliefs held by breast surgeons that impact the treatment decision process for advanced breast cancer patients: a qualitative study.

Breast Cancer (Dove Med Press) 2019 17;11:221-229. Epub 2019 Jul 17.

Department of Biomedical Ethics, The University of Tokyo Faculty of Medicine, Tokyo, Japan.

Introduction: Although guidelines do not recommend chemotherapy for patients with advanced cancer when death is imminent, many reports suggest the tendency to continue this treatment has been increasing every year. This study aimed to construct a model to clarify the beliefs and communication of doctors who administer chemotherapy to patients with recurrent or metastatic (hereafter, "recurrent/metastatic") breast cancer, and determine how these beliefs are related to the process of treating patients.

Materials And Methods: Semi-structured interviews were conducted with 21 breast surgeons, and interview contents were analyzed using the grounded theory approach in order to conceptualize the treatment process. Read More

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http://dx.doi.org/10.2147/BCTT.S208910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6645069PMC

Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment.

Breast Cancer (Dove Med Press) 2019 5;11:209-219. Epub 2019 Jul 5.

Cancer Research Institute, Tomsk National Research Medical Center, Tomsk 634050, Russia.

Chemotherapy, along with surgery and radiotherapy, is a key treatment option for malignant tumors. Neoadjuvant chemotherapy (NACT) reduces the tumor size and enables total tumor resection. In addition, NACT is believed to be more effective in destroying micrometastases than the same chemotherapy performed after surgery. Read More

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http://dx.doi.org/10.2147/BCTT.S175161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616300PMC
July 2019
1 Read

Knowledge and practices on breast cancer detection and associated challenges among women aged 35 years and above in Tanzania: a case in Morogoro Rural District.

Breast Cancer (Dove Med Press) 2019 28;11:191-197. Epub 2019 May 28.

Department of Epidemiology & Biostatistics, Institute of Public Health, Kilimanjaro Christian Medical University College, Moshi, Tanzania.

Breast cancer is the leading cause of cancer-related deaths among women globally including Tanzania. However, timely access to diagnosis remains a challenge due to lack of specialized facilities. Most patients presents with advanced stages of the disease making management impossible. Read More

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http://dx.doi.org/10.2147/BCTT.S199889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6554511PMC
May 2019
3 Reads

Quality of life of women with breast cancer undergoing treatment and follow-up at King Salman Armed Forces Hospital in Tabuk, Saudi Arabia.

Breast Cancer (Dove Med Press) 2019 27;11:199-208. Epub 2019 May 27.

Department of Surgery, King Salman Armed Forces Hospital, Northwestern Region, Tabuk 71411, Saudi Arabia.

Assessment of quality of life can significantly impact the diagnosis and treatment course of breast cancer, resulting in a better prognosis among patients. However, very limited data are available regarding quality of life among breast cancer patients in Saudi Arabia. To determine the quality of life of women with breast cancer referred to the Surgery Department of King Salman Armed Forces Hospital for treatment and follow-up. Read More

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http://dx.doi.org/10.2147/BCTT.S200605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549777PMC
May 2019
9 Reads

Variation in the management of elderly patients in two neighboring breast units is due to preferences and attitudes of health professionals.

Breast Cancer (Dove Med Press) 2019 8;11:179-188. Epub 2019 May 8.

Academic Unit of Surgery, University of Glasgow, Glasgow, UK.

Elderly breast cancer patients have been shown to be managed less aggressively than younger patients. There is evidence that their management varies between institutions. We audited the management of elderly patients in two neighboring units in Glasgow and aimed to identify reasons for any differences in practice found. Read More

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http://dx.doi.org/10.2147/BCTT.S194124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520595PMC
May 2019
4 Reads

Taxanes in the elderly patient with metastatic breast cancer [Corrigendum].

Authors:

Breast Cancer (Dove Med Press) 2019 3;11:189. Epub 2019 May 3.

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http://dx.doi.org/10.2147/BCTT.S207530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504247PMC
May 2019
1 Read

Metastasis inhibition in breast cancer by targeting cancer cell extravasation.

Breast Cancer (Dove Med Press) 2019 18;11:165-178. Epub 2019 Apr 18.

Department of Physiological Sciences, Federal University of São Carlos, São Carlos, SP, Brazil.

The spread of cells from primary tumors toward distant tissues and organs, also known as metastasis, is responsible for most cancer-associated deaths. The metastasis cascade comprises a series of events, characterized by the displacement of tumor cells (TCs) from the primary tumor to distant organs by traveling through the bloodstream, and their subsequent colonization. The first step in metastasis involves loss of cell-cell and cell-matrix adhesions, increased invasiveness and migratory abilities, leading to intravasation of TCs into the blood or lymphatic vessels. Read More

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http://dx.doi.org/10.2147/BCTT.S166725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497883PMC

Epidemiological characteristics of and risk factors for breast cancer in the world.

Breast Cancer (Dove Med Press) 2019 10;11:151-164. Epub 2019 Apr 10.

Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran,

Aim: Breast cancer is the most common cancer among women and one of the most important causes of death among them. This review aimed to investigate the incidence and mortality rates of breast cancer and to identify the risk factors for breast cancer in the world.

Materials And Methods: A search was performed in PubMed, Web of Science, and Scopus databases without any time restrictions. Read More

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https://www.dovepress.com/epidemiological-characteristics-of
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http://dx.doi.org/10.2147/BCTT.S176070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462164PMC
April 2019
31 Reads

Detection of human mammaglobin mRNA in breast cancer cells among Vietnamese women.

Breast Cancer (Dove Med Press) 2019 18;11:143-150. Epub 2019 Mar 18.

Department of Oncology, Thanh Nhan Hospital, Hanoi, Vietnam.

Background: Detecting circulating tumor cells (CTCs) is a promising approach for evaluating the progression of occult metastases as well as the efficacy of treatment therapies among patients with breast cancer. A real-time reverse transcriptase polymerase chain reaction (RT-PCR) technique has been proposed for detecting CTCs due to its high sensitivity. In this study, we aimed to validate the RT-PCR technique for human mammaglobin (hMAM) mRNA detection among Vietnamese women with breast cancer. Read More

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https://www.dovepress.com/detection-of-human-mammaglobin-mrn
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http://dx.doi.org/10.2147/BCTT.S193777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429994PMC
March 2019
18 Reads

Nano-curcumin's suppression of breast cancer cells (MCF7) through the inhibition of cyclinD1 expression.

Breast Cancer (Dove Med Press) 2019 13;11:137-142. Epub 2019 Mar 13.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran,

Background: Breast cancer is the leading cause of cancer worldwide. The high expenses associated with chemotherapy as well as its side effects make the management of breast cancer a daunting challenge. The most common overexpressed gene in breast cancer is cyclinD1, which induces cell proliferation. Read More

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http://dx.doi.org/10.2147/BCTT.S195800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420787PMC
March 2019
13 Reads

Targeting stem cells in the realm of drug-resistant breast cancer.

Breast Cancer (Dove Med Press) 2019 7;11:115-135. Epub 2019 Mar 7.

Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India,

Since its first documentation, breast cancer (BC) has been a conundrum that ails millions of women every year. This cancer has been well studied by researchers all over the world, which has improved the patient outcome significantly. There are many diagnostic markers to identify the disease, but early detection and then subclassification of this cancer remain dubious. Read More

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http://dx.doi.org/10.2147/BCTT.S189224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410754PMC
March 2019
2 Reads

Breast cancer risk in a rapidly aging population: advances and approaches to study the aging tissue microenvironment.

Authors:
Steven J Greco

Breast Cancer (Dove Med Press) 2019 19;11:111-113. Epub 2019 Feb 19.

Department of Medicine, Division of Hematology and Oncology, Rutgers-New Jersey Medical School, Newark, NJ, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385766PMC
http://dx.doi.org/10.2147/BCTT.S200949DOI Listing
February 2019
3 Reads

The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells.

Breast Cancer (Dove Med Press) 2019 19;11:99-110. Epub 2019 Feb 19.

Department of Biomedical Diagnostic and Therapeutic Sciences, School of Health Sciences, Oakland University, Rochester, MI 48309-4476, USA,

Background: Black cohosh (BC) is an herbal remedy often used by women to treat symptoms associated with menopause. Research has shown that the molecular activity of BC is associated with estrogen receptor alpha (ER-α) regulation. Progesterone receptor (PR) expression is found to be consistent with ER expression and mutations in the gene, a tumor-suppressor gene, are known to be responsible for about 40%-45% of hereditary breast cancers. Read More

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https://www.dovepress.com/the-antiestrogenic-effects-of-blac
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http://dx.doi.org/10.2147/BCTT.S181730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385778PMC
February 2019
24 Reads

Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration.

Breast Cancer (Dove Med Press) 2019 19;11:87-97. Epub 2019 Feb 19.

Breast Center, Department of Gynecology and Obstetrics and CCC Munich, University of Munich (LMU), 81377 Munich, Germany,

Objectives: A correlation exists between breast cancer and thyroid disorders, which are common in elderly women. Thyroid hormones are degraded into trace amines, which can bind to the G-protein-coupled receptor trace amine-associated receptor 1 (TAAR1) and thereby activate it. The transformation of thyroid hormones into trace amines is carried out by the ornithine decarboxylase. Read More

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http://dx.doi.org/10.2147/BCTT.S178721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385785PMC
February 2019
3 Reads

Breast cancer prevention in older women: an algorithm to choose an optimal preventive agent.

Breast Cancer (Dove Med Press) 2019 19;11:81-86. Epub 2019 Feb 19.

Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA,

Background: Breast cancer is a significant cause of morbidity and mortality in older women. The current study presents new, comprehensive guidelines for providing chemoprevention to older women.

Objective: The objective of this study was to develop and pilot test a chemopreventive choice algorithm to assess its feasibility for older women at high risk of breast cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S179486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385772PMC
February 2019
3 Reads

Overview of the genetic basis toward early detection of breast cancer.

Breast Cancer (Dove Med Press) 2019 21;11:71-80. Epub 2019 Jan 21.

Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka,

Cancer is a socioeconomical burden in any nation. Out of that, breast cancer is identified as the most common malignancy worldwide among women irrespective of age. As women are an important segment in a community, the weakening of their strength toward the development of a nation is a critical problem in each nation. Read More

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http://dx.doi.org/10.2147/BCTT.S185870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345186PMC
January 2019
1 Read

Immunotherapy for HER2-positive breast cancer: recent advances and combination therapeutic approaches.

Breast Cancer (Dove Med Press) 2019 17;11:53-69. Epub 2019 Jan 17.

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan.

Cancer immunotherapy has evolved dramatically with improved understanding of immune microenvironment and immunosurveillance. The immunogenicity of breast cancer is rather heterogeneous. Specific subtypes of breast cancer such as estrogen receptor (ER)-negative, human EGF receptor 2 (HER2)-positive, and triple-negative breast cancer (TNBC) have shown evidence of immunogenicity based on tumor-immune interactions. Read More

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http://dx.doi.org/10.2147/BCTT.S175360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340364PMC
January 2019
3 Reads

Efficacy and tolerability of BP-C1 in metastatic breast cancer: a Phase II, randomized, double-blind, and placebo-controlled Thai multi-center study.

Breast Cancer (Dove Med Press) 2019 14;11:43-51. Epub 2019 Jan 14.

Digestive Disease Center, Centre for Epidemiology and Biostatistics, Norwegian University of Life Sciences, Oslo, Norway,

Aims: The aim of this study was to compare the efficacy and tolerability of BP-C1 vs equal-looking placebo in metastatic breast cancer.

Materials And Methods: A randomized, double-blind, placebo-controlled multi-center study with a semicross-over design was performed. Sixteen patients received daily intramuscular injection of 0. Read More

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http://dx.doi.org/10.2147/BCTT.S174298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336026PMC
January 2019
3 Reads

Primary systemic therapy in HER2-positive operable breast cancer using trastuzumab and chemotherapy: efficacy data, cardiotoxicity and long-term follow-up in 142 patients diagnosed from 2005 to 2016 at a single institution.

Breast Cancer (Dove Med Press) 2019 27;11:29-42. Epub 2018 Dec 27.

Medical Oncology Department, Breast Unit, A Coruña University Hospital, A Coruña, Spain,

Objective: The aim of this study was to evaluate the efficacy, cardiotoxicity profile and long-term benefits of neoadjuvant therapy in human epidermal growth factor receptor 2-positive operable breast cancer patients.

Patients And Methods: A total of 142 patients diagnosed from 2005 to 2016 were included in the study. The treatment consisted of a sequential regimen of taxanes and anthracyclines plus trastuzumab. Read More

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https://www.dovepress.com/primary-systemic-therapy-in-her2-p
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http://dx.doi.org/10.2147/BCTT.S179750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311333PMC
December 2018
30 Reads

Assessment of breast self-examination practice and its associated factors among female undergraduate students in Addis Ababa University, Addis Ababa, Ethiopia, 2016.

Breast Cancer (Dove Med Press) 2019 28;11:21-28. Epub 2018 Dec 28.

Department of Nursing, Faculty of Health Science, Woldia University, Woldia, Ethiopia,

Background: Breast self-examination (BSE) is a simple, very low-cost, non-invasive early detection method used to detect breast cancer at early stage. It should be done for all women older than 20 years. The aim of this study was to assess BSE practice and associated factors among female undergraduate students in Addis Ababa University, Addis Ababa, Ethiopia. Read More

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https://www.dovepress.com/assessment-of-breast-self-examinat
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http://dx.doi.org/10.2147/BCTT.S189023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312690PMC
December 2018
4 Reads

Axillary web syndrome following breast cancer surgery: symptoms, complications, and management strategies.

Breast Cancer (Dove Med Press) 2019 20;11:13-19. Epub 2018 Dec 20.

University of Minnesota, Masonic Cancer Center, Minneapolis, MN, USA,

Axillary web syndrome (AWS) is a common condition occurring in up to 86% of patients following breast cancer surgery with ipsilateral lymphadenectomy of one or more nodes. AWS presents as a single cord or multiple thin cords in the subcutaneous tissues of the ipsilateral axilla. The cords may extend variable distances "down" the ipsilateral arm and/or chest wall. Read More

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http://dx.doi.org/10.2147/BCTT.S146635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304256PMC
December 2018
2 Reads

LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women.

Breast Cancer (Dove Med Press) 2019 20;11:1-12. Epub 2018 Dec 20.

Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA,

Background: Triple-negative breast cancer (TNBC) is more prevalent in African and African American (AA) women compared to European American (EA) women. African and AA women diagnosed with TNBC experience high frequencies of metastases and less favorable outcomes. Emerging evidence indicates that this disparity may in fact be the result of the uniquely aggressive biology of African and AA disease. Read More

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http://dx.doi.org/10.2147/BCTT.S185960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304259PMC
December 2018
3 Reads

Palliative care: needs of advanced breast cancer patients.

Breast Cancer (Dove Med Press) 2018 3;10:231-243. Epub 2018 Dec 3.

Integrated Oncology and Palliative Medicine Department, Breast Oncology Unit, Shaare Zedek Medical Center, Jerusalem, Israel,

Advanced breast cancer is characterized by many physical manifestations with the potential to undermine the quality of life (most related to the cancer and some to treatments), as well as substantial impact on psychosocial well-being. Patients with advanced breast cancer and their families have complex needs that have to be addressed in order to minimize severe distress and deterioration in the quality of life of patients and their family members. This task requires the full engagement of an interdisciplinary approach to palliative care with strong emphasis on the assessment of needs and anticipated needs, patient expectations, skilled therapeutics, and commitment to continuity of care. Read More

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https://www.dovepress.com/palliative-care-needs-of-advanced-
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http://dx.doi.org/10.2147/BCTT.S160462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284851PMC
December 2018
10 Reads

Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action.

Breast Cancer (Dove Med Press) 2018 29;10:207-217. Epub 2018 Nov 29.

Faculty of Nursing, University of Babylon, Babylon, Iraq.

p53 is a tumor suppressor gene involved in various cellular mechanisms including DNA repair, apoptosis, and cell cycle arrest. More than 50% of human cancers have a mutated nonfunctional p53. Breast cancer (BC) is one of the main causes of cancer-related deaths among females. Read More

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https://www.dovepress.com/role-of-curcumin-in-regulating-p53
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http://dx.doi.org/10.2147/BCTT.S167812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276637PMC
November 2018
21 Reads

A single-nucleotide polymorphism of the beta 2-adrenergic receptor gene can predict pathological complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer.

Breast Cancer (Dove Med Press) 2018 27;10:201-206. Epub 2018 Nov 27.

Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China,

Background: Germline genetic polymorphisms in certain genes are associated with the response to anthracycline- and taxane-based neoadjuvant chemotherapy in breast cancer (BC). This translational study aims to evaluate the potential role of rs1042713 in the beta 2-adrenergic receptor () gene in predicting pathological complete responses (pCRs) to taxane- and platinum-based neoadjuvant chemotherapy in locally advanced breast cancer (LABC).

Materials And Methods: The distribution frequencies of rs1042713 were genotyped in LABC patients who received taxane- and platinum-based neoadjuvant chemotherapy. Read More

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http://dx.doi.org/10.2147/BCTT.S189197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267711PMC
November 2018
2 Reads

Artificial intelligence methods for the diagnosis of breast cancer by image processing: a review.

Breast Cancer (Dove Med Press) 2018 30;10:219-230. Epub 2018 Nov 30.

Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran,

Breast cancer is the most common cancer among women around the world. Despite enormous medical progress, breast cancer has still remained the second leading cause of death worldwide; thus, its early diagnosis has a significant impact on reducing mortality. However, it is often difficult to diagnose breast abnormalities. Read More

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http://dx.doi.org/10.2147/BCTT.S175311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278839PMC
November 2018
2 Reads

Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases.

Breast Cancer (Dove Med Press) 2018 23;10:195-199. Epub 2018 Nov 23.

Department of Breast Surgery, Breast Center, Kameda Medical Center, Chiba, Japan,

Background: Identification of the proteins that are associated with estrogen receptor (ER) status is a first step in selecting drugs against hormone-dependent breast cancer. Recently, the proteins associated with ER status were reported using liquid chromatography and tandem mass spectrometry, and microRNA (miRNA) profiling of breast cancer subtype was demonstrated using real-time-PCR.

Methods: We present herein two cases with differential protein expression and miRNA profiling in ER-positive and -negative breast cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S181652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257358PMC
November 2018
5 Reads

Potential clinically useful prognostic biomarkers in triple-negative breast cancer: preliminary results of a retrospective analysis.

Breast Cancer (Dove Med Press) 2018 23;10:177-194. Epub 2018 Nov 23.

University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania,

Background: Triple-negative breast cancer (TNBC) has a poor prognosis, even in its early stages. In the absence of postoperative targeted treatments, intensive adjuvant chemotherapy regimens are proposed. For those favorable histologies, such as apocrine and adenoid cystic carcinoma, which frequently belong to TNBC, aggressive treatments are unnecessary. Read More

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http://dx.doi.org/10.2147/BCTT.S175556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257362PMC
November 2018
3 Reads

Expression of chemerin correlates with a poor prognosis in female breast cancer patients.

Breast Cancer (Dove Med Press) 2018 23;10:169-176. Epub 2018 Oct 23.

Department of Internal Medicine, Deraya University, Minia, Egypt.

Objective: Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. Read More

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https://www.dovepress.com/expression-of-chemerin-correlates-
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http://dx.doi.org/10.2147/BCTT.S178181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207381PMC
October 2018
14 Reads

Intracellular aggregated TRPV1 is associated with lower survival in breast cancer patients.

Breast Cancer (Dove Med Press) 2018 15;10:161-168. Epub 2018 Oct 15.

Laboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda, Valparaíso, Chile,

Background: Breast cancer is a malignant disease that represents an important public health burden. The description of new molecular markers can be important to diagnosis, classification, and treatment. Transient receptor potential vanilloid 1 (TRPV1) polymodal channel is expressed in different neoplastic tissues and cell lines of breast cancer and associated with the regulation of tumor growth, tumor neurogenesis, cancer pain, and malignant progression of cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S170208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197232PMC
October 2018
25 Reads

Psychological symptoms in adult Saudi Arabian cancer patients: prevalence and association with self-rated oral health.

Breast Cancer (Dove Med Press) 2018 3;10:153-159. Epub 2018 Oct 3.

Department of Oncology, King Abdulaziz Medical City for National Guard, Ministry of National Guard, Riyadh, Saudi Arabia.

Background: Although psychological symptoms and oral health status are associated with health management and outcomes among cancer patients, their association has not been assessed in Saudi Arabia. We aimed to assess the symptoms of depression, anxiety, and stress and their association with their oral health status, adjusting for sociodemographic and clinical factors.

Methods: A self-reported study included 375 adult cancer patients who received outpatient healthcare services in the Oncology Department, King Abdulaziz Medical City-Riyadh, Saudi Arabia, between April 1 and August 31, 2017. Read More

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http://dx.doi.org/10.2147/BCTT.S168139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174894PMC
October 2018
8 Reads

Hypofractionated radiotherapy after conservative surgery may increase low-intermediate grade late fibrosis in breast cancer patients.

Breast Cancer (Dove Med Press) 2018 3;10:143-151. Epub 2018 Oct 3.

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Aim: To compare late toxicity after postoperative hypofractionated radiotherapy (RT) and standard fractionated RT in patients with early-stage breast carcinoma.

Methods: This retrospective study included 447 patients (Modulated Accelerated Radiotherapy [MARA-1]: 317 patients, and control group [CG]: 130 patients). In the CG, the whole breast received 50. Read More

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http://dx.doi.org/10.2147/BCTT.S167914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174899PMC
October 2018
11 Reads