478,298 results match your criteria Breast cancer : basic and clinical research[Journal]


Exploring the Roles of Central and Peripheral Nervous System Function in Gait Stability: Preliminary Insights from Cancer Survivors.

Gait Posture 2019 Apr 6;71:62-68. Epub 2019 Apr 6.

Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA; School of Health & Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA.

Background: Impairments in central and/or peripheral nervous systems are known to be associated with altered gait; however, the interplay between cognitive function, peripheral sensation, and orbital gait stability remains largely unclear. Elucidating these relationships is expected to provide a clearer understanding of potential fall risk factors across various populations and targets for novel interventions. Many patients diagnosed with cancer are treated with chemotherapy agents known to be neurotoxic to the central and/or peripheral nervous systems that can contribute to movement deficiencies, making this population a novel model to investigate these relationships. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09666362183163
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http://dx.doi.org/10.1016/j.gaitpost.2019.04.002DOI Listing
April 2019
1 Read

Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
1 Read

Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.

Semin Cancer Biol 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

At present, the belief that genetic mutations control every aspect of tumorigenesis is still very popular. Even for the highly debated "bad luck" theory of cancers, it ascertained that random mutation of genes during the self-renewal of somatic stem cells is responsible for cancer initiation. Logically, most of the new therapeutic strategies so far, from molecular targeting to precision medicine or personalized medicine, are genome-obsessed and focused on identifying and targeting these mutated genes. Read More

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http://dx.doi.org/10.1016/j.semcancer.2019.04.003DOI Listing

Nitric oxide and interactions with reactive oxygen species in the development of melanoma, breast, and colon cancer: A redox signaling perspective.

Nitric Oxide 2019 Apr 19. Epub 2019 Apr 19.

New York University School of Medicine, New York, NY, USA.

Cancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammatory tumor microenvironment play an essential role in directly influencing intercellular and intracellular signaling. These reactive species originating in the cancer cell or its microenvironment, mediate the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET). Read More

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http://dx.doi.org/10.1016/j.niox.2019.04.009DOI Listing

Synergistic effects of 7-O-geranylquercetin and siRNAs on the treatment of human breast cancer.

Life Sci 2019 Apr 19. Epub 2019 Apr 19.

College of Pharmacy, Dalian Medical University, Dalian 116044, China. Electronic address:

Aims: To investigate the antitumor effect of 7-O-geranylquercetin (GQ) combining with survivin siRNA (siSuvi) or IL-10 siRNA (siIL-10) to breast cancer.

Main Methods: Xenograft tumor model was established by subcutaneously inoculating human breast cancer MCF-7 cells in BALB/c nude mice. Transfection efficiency of siRNA mediated by cationic liposome CDO14 in MCF-7 cells and tumor bearing mice was measured by flow cytometer and living imaging sysytem, respectively. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.047DOI Listing

Rapid profiling of triglycerides in human breast milk using LESA-FTMS reveals new VLCFAs and differences within individuals.

Rapid Commun Mass Spectrom 2019 Apr 22. Epub 2019 Apr 22.

Nutrition and Bone Health group MRC HNR, Cambridge, CB1 9NL, United Kingdom.

Rationale: In this paper, we describe a novel method for preparing milk samples and profiling the triglyceride fraction from them. This method was used to explore how the triglyceride (TG) profile of milk modulates as lactation progresses and how the TG profile differs between breasts.

Methods: Fresh milk was spotted onto Whatman filter paper and air-dried. Read More

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http://dx.doi.org/10.1002/rcm.8465DOI Listing
April 2019
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Involvement of miR-770-5p in trastuzumab response in HER2 positive breast cancer cells.

PLoS One 2019 22;14(4):e0215894. Epub 2019 Apr 22.

Biotechnology Institute, Ankara University, Ankara, Turkey.

miRNAs may play effective roles in breast cancer so modulating their expression levels could have therapeutic benefits. Recent studies have found the combination of miRNA-based therapeutics with conventional drugs as promising. This study aimed to find drug-responsive miRNAs, and explore their anticancer activities in HER2+ breast cancer cells and regulatory role in the trastuzumab response. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215894PLOS

Cancer-related fatigue stratification system based on patient-reported outcomes and objective outcomes: A cancer-related fatigue ambulatory index.

PLoS One 2019 22;14(4):e0215662. Epub 2019 Apr 22.

Department of Physiotherapy, Faculty of Health Sciences, Universidad de Malaga, Málaga, Spain.

Although breast cancer mortality is decreasing, morbidity following treatment remains a significant issue, as patients face symptoms such as cancer-related fatigue (CRF). The aim of the present study is to develop a classification system that monitors fatigue via integration of an objective clinical assessment with patient self-report. Forty-three women participated in this research. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215662PLOS

Comment on "US FDA Breast Implant Postapproval Studies: Long-term Outcomes in 99,993 Patients".

Ann Surg 2019 Apr 18. Epub 2019 Apr 18.

Past President, American Society of Plastic Surgeons, Lenox Hill Hospital/Manhattan Eye, Ear, and Throat Hospital, Northwell Health System, Hofstra School of Medicine, New York, NY Past President, American Society for Aesthetic Plastic Surgery, Aesthetic Plastic Surgical Institute, Laguna Beach, CA; Loma Linda University, Loma Linda, CA Past President, American Society for Aesthetic Plastic Surgery, Private Practice, Eugene, OR Loma Linda University Medical Center, Loma Linda, CA.

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http://dx.doi.org/10.1097/SLA.0000000000003293DOI Listing
April 2019
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Recombinant Expression of Zinc Transporter SLC39A6 and Its Functional Antibody Production.

Monoclon Antib Immunodiagn Immunother 2019 Apr;38(2):70-74

1 Biotechnology Research Center, Venom and Biotherapeutics Molecules Laboratory, Pasteur Institute of Iran, Tehran, Iran.

Zinc transporter ZIP6 (SLC39A6) or LIV-1 is a protein that belongs to a subfamily of proteins group that displays structural specifications of zinc transporters in the cell membrane. Overexpression of this protein is observed in breast, prostate, and kidney tumor cells. Lately, LIV-1 is a dependable marker for detection of estrogen receptor positive breast cancer, which can be used to detect luminal breast cancer type A. Read More

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http://dx.doi.org/10.1089/mab.2018.0045DOI Listing

Identification and Management of Lymphedema in Patients With Breast Cancer.

J Oncol Pract 2019 Apr 22:JOP1800141. Epub 2019 Apr 22.

1 Nebraska Medical Center, Omaha, NE.

Breast cancer-related lymphedema (BCRL) is a potentially debilitating and often irreversible complication of breast cancer treatment. Risk of BCRL is proportional to the extent of axillary surgery and radiation. Other risk factors include obesity and infections. Read More

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http://dx.doi.org/10.1200/JOP.18.00141DOI Listing

microRNA-370 Promotes Cell Growth by Targeting WNK2 in Breast Cancer.

DNA Cell Biol 2019 Apr 22. Epub 2019 Apr 22.

Central Hospital of Zibo, Zhangdian District, Zibo, Shandong, China.

Aberrant expression of microRNA-370 (miR-370) has been found in many types of human cancers. In non-small cell lung cancer, miR-370 is a tumor suppressor with decreased expression. In prostate cancer, it is an oncogene with overexpression. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4602
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http://dx.doi.org/10.1089/dna.2018.4602DOI Listing
April 2019
2 Reads

Combination of Human Umbilical Vein Endothelial Cell Vaccine and Docetaxel Generates Synergistic Anti-Breast Cancer Effects.

Cancer Biother Radiopharm 2019 Apr 22. Epub 2019 Apr 22.

1 The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Yantai, P.R. China.

A human umbilical vein endothelial cell (HUVEC) vaccine is a promising anti-angiogenesis therapy, but the modest therapeutic antitumor efficacy restricts its clinical use. Preclinical evidence supports the combination of antiangiogenic agents and chemotherapy for cancer treatment. In the present study, docetaxel (DOC) was combined with HUVEC vaccine to develop a HUVEC-DOC treatment regime. Read More

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http://dx.doi.org/10.1089/cbr.2018.2721DOI Listing

Salinomycin-loaded gold nanoparticles for treating cancer stem cells by ferroptosis-induced cell death.

Mol Pharm 2019 Apr 22. Epub 2019 Apr 22.

Cancer Stem Cells (CSCs) are a subpopulation of tumor cells which exhibits self-renewal, differentiation and tumorigenicity. CSCs are highly resistant to conventional cancer treatment and have been associated with metastasis. Several studies have been shown that salinomycin (Sal) has the potential to target cancer stem cells and evidenced by in vitro and in vivo tumor models. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00132DOI Listing

Design, synthesis, and biological evaluation of lipophilically modified bisphenol Z derivatives.

Chem Biol Drug Des 2019 Apr 22. Epub 2019 Apr 22.

The University of Findlay, College of Pharmacy, 1000 North Main Street, Findlay, OH, 45840.

In the present study, a small library of bisphenol Z (BPZ) derivatives was synthesized and investigated for anti-proliferative effects in cultured breast and glioblastoma cell lines. Synthesized BPZ derivatives varied in molecular size, polarity, and lipophilicity. Of the 8 derivatives tested, compounds 4 and 6, both of which displayed the highest degree of lipophilicity, were most active at inducing cell death as determined by the XTT assay. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13531
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http://dx.doi.org/10.1111/cbdd.13531DOI Listing
April 2019
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Case report of long-term survival with metastatic triple-negative breast carcinoma: Treatment possibilities for metastatic disease.

Medicine (Baltimore) 2019 Apr;98(16):e15302

Lifespring Cancer Treatment Center, Seattle, WA.

Rationale: Breast cancer is the most common as well as one of the most devastating cancers among women in the United States. Prognosis is poor for patients with metastatic breast cancer, especially for patients with so-called "triple-negative" disease. The lack of effective therapies for metastatic triple-negative breast cancer outlines the need for novel and innovative treatment strategies. Read More

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http://dx.doi.org/10.1097/MD.0000000000015302DOI Listing

Depression involved in self-reported prospective memory problems in survivors of breast cancer who have received chemotherapy.

Medicine (Baltimore) 2019 Apr;98(16):e15301

Department of Oncology, The Second Affiliated Hospital of Anhui Medical University.

To investigate the relationship between depression and the self-reported prospective memory (SPM) problems in breast cancer survivors who have received chemotherapy.Sixty-three breast cancer patients were administered with self-rating depression scale (SDS) and the prospective memory questionnaire as part of extensive neuropsychological assessments before and after chemotherapy. The performance of SDS and SPM were compared, with the level of significance set at P < . Read More

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http://dx.doi.org/10.1097/MD.0000000000015301DOI Listing

The clinicopathological significance of ubiquitin-conjugating enzyme E2C, leucine-rich repeated-containing G protein-coupled receptor, WW domain-containing oxidoreductase, and vasculogenic mimicry in invasive breast carcinoma.

Medicine (Baltimore) 2019 Apr;98(16):e15232

Department of Pathology, Zhenjiang First People's Hospital, Affiliated to Jiangsu University.

Ubiquitin-conjugating enzyme E2C (UBE2C), a crucial part of the ubiquitin-conjugating enzyme complex, is reported to promote progression of various cancers. Leucine-rich repeated-containing G protein-coupled receptor (LGR5), a biomarker of cancer stem cells, is reported to be responsible for the initiation and progression of cancers. WW domain-containing oxidoreductase (WWOX), a suppressor of tumor, is reported to inhibit initiation and progression of cancers. Read More

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http://dx.doi.org/10.1097/MD.0000000000015232DOI Listing

Role of programmed cell death ligand-1 expression on prognostic and overall survival of breast cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2019 Apr;98(16):e15201

Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing, China.

Background: Recently, the correlation of immunological checkpoint marker programmed cell death ligand-1 (PD-L1) and the prognosis of various cancers has been a research hotspot. The aim of this study is to examine the prognostic effect of PD-L1 in breast cancer.

Methods: PubMed, EMBASE, Web of Science, the Cochrane Library database were searched for eligible studies and additional hand-searching were reviewed as an augmentation. Read More

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http://dx.doi.org/10.1097/MD.0000000000015201DOI Listing

Impact of full field digital mammography diagnosis for female patients with breast cancer.

Medicine (Baltimore) 2019 Apr;98(16):e15175

Department of Computed Tomography, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

Background: Previous clinical studies have reported that full field digital mammography (FFDM) can be used for diagnosis on breast cancer (BC) with promising outcome results. However, no study systematically investigates its diagnostic impact on female patients with BC. Thus, this systematic review will assess the accurate of FFDM diagnosis on BC. Read More

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http://dx.doi.org/10.1097/MD.0000000000015175DOI Listing

A case report on metastatic ileal neuroendocrine neoplasm to the breast masquerading as primary breast cancer: A diagnostic challenge and management dilemma.

Medicine (Baltimore) 2019 Apr;98(16):e14989

1st Department of Surgery, Laikon General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Rationale: Metastatic neuroendocrine neoplasms (NENs) to the breast are very rare entities comprising only 1% to 2% of all metastatic breast tumors. In this article, we describe a case of a neuroendocrine ileal neoplasm metastatic to breast and liver, with breast metastatic tumor to be the initial manifestation of the disease.

Patient Concerns: We herein report a rare case of a female patient admitted to our department with a palpable painful mass on her left breast. Read More

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http://dx.doi.org/10.1097/MD.0000000000014989DOI Listing
April 2019
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Neuronavigator-guided ventriculoscopic approach for symptomatic xanthogranuloma of the choroid plexus in the lateral ventricle.

Medicine (Baltimore) 2019 Apr;98(16):e14718

Department of Neurosurgery, Peking University International Hospital.

Xanthogranuloma of choroid plexus is an extremely rare, benign, and mostly asymptomatic intracranial lesion. We report a case of symptomatic lateral ventricular xanthogranuloma resected via a neuronavigator-guided ventriculoscopic approach. Then we review recent English medical literature and notice that craniotomies have been the most popular treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000014718DOI Listing

Reply to Novel Approach for Risk-Reducing Mastectomy: First-Stage Implant Placement and Subsequent Second-Stage Mastectomy.

Plast Reconstr Surg 2019 Apr 15. Epub 2019 Apr 15.

Breast Unit, St Bartholomew's Hospital, London, United Kingdom.

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http://dx.doi.org/10.1097/PRS.0000000000005729DOI Listing

Surgical Decision Making in DIEP Flap Breast Reconstruction.

Plast Reconstr Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Plastic Surgery, UT Southwestern Medical Center, 1801 Inwood Road, Dallas, TX 75390-9132, Phone: 214-645-2353.

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http://dx.doi.org/10.1097/PRS.0000000000005731DOI Listing

Association Between Degrees of Separation in Physician Networks and Surgeons' Use of Perioperative Breast Magnetic Resonance Imaging.

Med Care 2019 Apr 18. Epub 2019 Apr 18.

Cancer Outcomes, Public Policy and Effectiveness Research (COPPER) Center, Yale Cancer Center and Yale School of Medicine.

Background: Perioperative magnetic resonance imaging (MRI) is frequently used in breast cancer despite unproven benefits. It is unclear whether surgeons' use of breast MRI is associated with the practices of other surgeons to whom they are connected through shared patients.

Methods: We conducted a retrospective study using Medicare data to identify physicians providing breast cancer care during 2007-2009 and grouped them into patient-sharing networks. Read More

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http://dx.doi.org/10.1097/MLR.0000000000001123DOI Listing

Comment: First Lymphaticovenular Anastomosis for Female and Male Breast Lymphedema.

Ann Plast Surg 2019 Apr 3. Epub 2019 Apr 3.

Department of Plastic and Reconstructive Surgery Sud Francilien Hospital University Paris Sud XI Evry, France

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http://dx.doi.org/10.1097/SAP.0000000000001863DOI Listing

Multicenter retrospective study to evaluate the impact of trabectedin plus pegylated liposomal doxorubicin on the subsequent treatment in women with recurrent, platinum-sensitive ovarian cancer.

Anticancer Drugs 2019 Apr 18. Epub 2019 Apr 18.

Navarra University Clinic Madrid.

Debulking surgery, followed by taxane/platinum-based chemotherapy has traditionally been the first-line treatment for advanced ovarian cancer. However, most patients will experience recurrence afterwards, and receive subsequent lines of therapy. It has been proposed that extending the treatment-free interval of platinum can improve the response to a subsequent platinum-based chemotherapy, and reduce associated toxicities in women with recurrent, platinum-sensitive ovarian cancer. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000794DOI Listing

Clinical pharmacokinetics and pharmacogenetics of tamoxifen and endoxifen.

Expert Rev Clin Pharmacol 2019 Apr 22. Epub 2019 Apr 22.

a Leiden Network for Personalised Therapeutics , Leiden University Medical Center , Leiden , The Netherlands.

Introduction: Tamoxifen dominates the anti-estrogenic therapy in the early and metastatic breast cancer setting. Tamoxifen has a complex metabolism, being mainly metabolized by CYP2D6 into its 30-100 times more potent metabolite, endoxifen. Recently, a phase I study in which endoxifen as an orally z-endoxifen hydrochloride, has been successfully evaluated. Read More

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http://dx.doi.org/10.1080/17512433.2019.1610390DOI Listing

Dendrimer mediated targeting of siRNA against Polo-like kinase for the treatment of triple negative breast cancer.

J Biomed Mater Res A 2019 Apr 22. Epub 2019 Apr 22.

Department of General Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, Lodz 90-301, Poland.

Irresponsiveness of triple-negative breast cancer (TNBC) towards conventional therapies has drawn attention towards siRNA therapeutics. In gene delivery, dendrimers are gaining significant attention due to their characteristic features and polo-like kinase (PLK1) is reported as a potential target for TNBC. In this work, phosphorus and polyamidoamine dendrimer (generation 3 and 4 of each type) are explored to address delivery challenges of PLK1 siRNA (siPLK1). Read More

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http://dx.doi.org/10.1002/jbm.a.36701DOI Listing

Polygenic Influences on Pubertal Timing and Tempo and Depressive Symptoms in Boys and Girls.

J Res Adolesc 2019 Apr 22. Epub 2019 Apr 22.

Purdue University.

This study used polygenic scoring (PGS) to test whether puberty-related genes were correlated with depressive symptoms, and whether there were indirect effects through pubertal maturation. The sample included 8,795 adolescents from the Avon Longitudinal Study of Parents and Children (measures of puberty drawn ages 8-17 years; of depressive symptoms at age 16.5 years). Read More

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http://dx.doi.org/10.1111/jora.12502DOI Listing

3D static optical coherence elastography based on inverse compositional Gauss-Newton (IC-GN) digital volume correlation.

J Biophotonics 2019 Apr 22:e201800422. Epub 2019 Apr 22.

Department of Mechanical Engineering, Tianjin Key Laboratory of Modern Engineering Mechanics, Tianjin University, Tianjin, China.

The three-dimensional (3D) mechanical properties characterization of tissue is essential for physiological and pathological studies, as biological tissue is mostly heterogeneous and anisotropic. A digital volume correlation (DVC)-based 3D optical coherence elastography (OCE) method is developed to measure the 3D displacement and strain tensors. The DVC algorithm includes a zero-mean normalized cross-correlation criterion based coarse search regime, an inverse compositional Gauss-Newton fine search algorithm and a local ternary quadratic polynomial fitting strain calculation method. Read More

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http://dx.doi.org/10.1002/jbio.201800422DOI Listing

Medical and information needs among young women with breast cancer in Mexico.

Eur J Cancer Care (Engl) 2019 Apr 22:e13040. Epub 2019 Apr 22.

Joven & Fuerte: Program for the Care and Research of Young Women with Breast Cancer in Mexico, Mexico City, Mexico.

Objective: To describe clinical and information needs, identify unmet support services and guide interventions for young breast cancer (BC) patients in Mexico.

Methods: Cross-sectional, qualitative study, using interpretive description methodology. Patients with initial BC diagnosis within 6-12 months prior to enrolment, ≤40 years old and literate were included in focus groups. Read More

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http://dx.doi.org/10.1111/ecc.13040DOI Listing

Prevalence and factors associated with unmet needs in post-treatment cancer survivors: A systematic review.

Eur J Cancer Care (Engl) 2019 Apr 22:e13060. Epub 2019 Apr 22.

Department of Family Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Cancer survivors may experience unmet needs beyond the end of their treatment. This paper aimed to explore the prevalence and most frequently found unmet needs and to identify factors associated with higher levels of total unmet needs and with each domain separately. Five databases were searched using the keywords neoplasms, survivors, needs assessment, health services' needs and demands. Read More

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http://dx.doi.org/10.1111/ecc.13060DOI Listing

Integrin α9 depletion promotes β-catenin degradation to suppress triple negative breast cancer tumor growth and metastasis.

Int J Cancer 2019 Apr 22. Epub 2019 Apr 22.

Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease, College of Medicine, University of Kentucky, Lexington, Kentucky.

Although integrin α9 (ITGA9) is known to be involved in cell adhesion and motility, its expression in cancer and its role in tumor growth and metastasis remain largely unknown. This study was designed to investigate the role of ITGA9 in triple negative breast cancer (TNBC). ITGA9 expression in TNBC cells were knocked out (KO) using CRISPR/Cas9 technology. Read More

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http://dx.doi.org/10.1002/ijc.32359DOI Listing

Perfluorinated alkylated substances serum concentration and breast cancer risk: Evidence from a nested case-control study in the French E3N cohort.

Int J Cancer 2019 Apr 22. Epub 2019 Apr 22.

CESP, Fac. de médecine, Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France.

Endocrine-disrupting chemicals are proposedto increase breast cancer (BC) incidence. Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), two perfluorinated alkylated substances (PFASs), are suspected to be ubiquitously present in the blood of human population worldwide. We investigated the associations between serum concentrations of these substances and BC risk. Read More

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http://dx.doi.org/10.1002/ijc.32357DOI Listing

Final Results of the Prospective FH02 Mammographic Surveillance Study of Women Aged 35-39 at Increased Familial Risk of Breast Cancer.

EClinicalMedicine 2019 Jan;7:39-46

Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine' Charterhouse Square, London EC1M 6BQ, UK.

Background: Many women who are at increased risk of breast cancer due to a mother or sister diagnosed with breast cancer aged under 40 do not currently qualify for surveillance before 40 years of age. There are almost no available data to assess whether mammography screening aged 35-39 years would be effective in this group, in terms of detection of breast cancer at an early stage or cost effective.

Methods: A cohort screening study (FH02) with annual mammography was devised for women aged 35-39 to assess the sensitivity and screening performance and potential survival of women with identified tumours. Read More

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http://dx.doi.org/10.1016/j.eclinm.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472550PMC
January 2019

Predictors of fragility fracture and low bone mineral density in patients with a history of parental fracture.

Osteoporos Sarcopenia 2019 Mar 15;5(1):6-10. Epub 2019 Mar 15.

University Hospitals of Morecambe Bay NHS Foundation Trust, Royal Lancaster Infirmary, Rheumatology, Ashton Road, Lancaster, Lancashire, UK.

Objectives: Bone mineral density (BMD) and fragility fracture (FF) have high heritability, but few data exist on impact of other factors on families with fracture history. We aimed to evaluate predictors of FF and low BMD, in patients with family history of FF.

Methods: This was a retrospective study on patients undergoing dual energy X-ray absorptiometry at a district general hospital (DGH), 2004-2016. Read More

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http://dx.doi.org/10.1016/j.afos.2019.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452922PMC

Rosai-Dorfman disease simulating metastatic breast carcinoma.

JAAD Case Rep 2019 Apr 5;5(4):372-374. Epub 2019 Apr 5.

Department of Dermatology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.jdcr.2019.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454097PMC

Using information sources by breast cancer women treated with mastectomy.

J Educ Health Promot 2019 14;8:68. Epub 2019 Mar 14.

PhD in Information Sciences and Knowledge Studies, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Awareness of sources of information of mastectomy patients has an important role in accessibility of reliable health information sources, thus, when they get information, they can be effective in the treatment and self-care. The present study aimed to identify the sources of information used by women underwent mastectomy.

Materials And Methods: The current practical research methodology was qualitative, and research method was conventional qualitative content analysis was performed on 17 patients with breast cancer undergone mastectomy. Read More

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http://dx.doi.org/10.4103/jehp.jehp_224_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442256PMC

Perceived risk of colorectal and breast cancers among women who are overweight or with obesity.

Prev Med Rep 2019 Jun 22;14:100845. Epub 2019 Mar 22.

Research fellow, Oak Ridge Institute for Science Education (ORISE), Division of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States of America.

Many overweight women or women with obesity do not acknowledge their high weight status and may be unaware of their elevated cancer risk. We explored the relationship between weight status and women's perceived risk of colorectal (CRC) and breast cancers, overall and by race/ethnicity, in a nationally representative sample. Data was combined from NHIS 2005, 2010, and 2015 sample adult questionnaires and cancer control supplements. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22113355193003
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http://dx.doi.org/10.1016/j.pmedr.2019.100845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458496PMC
June 2019
1 Read

Enhanced Photothermal Treatment Efficacy and Normal Tissue Protection via Vascular Targeted Gold Nanocages.

Nanotheranostics 2019 22;3(2):145-155. Epub 2019 Mar 22.

Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR.

A major challenge in photothermal treatment is generating sufficient heat to eradicate diseased tissue while sparing normal tissue. Au nanomaterials have shown promise as a means to achieve highly localized photothermal treatment. Toward that end, the synthetic peptide anginex was conjugated to Au nanocages. Read More

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http://dx.doi.org/10.7150/ntno.32395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470343PMC

Synthesis and Feasibility Evaluation of a new Trastuzumab Conjugate Integrated with Paclitaxel and Zr for Theranostic Application Against HER2-Expressing Breast Cancers.

ChemistryOpen 2019 Apr 8;8(4):451-456. Epub 2019 Apr 8.

Division of Applied RI Korea Institute of Radiological and Medical Sciences 75 Nowon-ro, Nowon-gu Seoul Korea 01812.

The preparation and   evaluation of a theranostic conjugate composed of trastuzumab, paclitaxel (PTX), and deferoxamine (DFO)-chelated Zr have been reported. These comounds have potential applications against HER2 receptor positive breast cancers. We conjugated DFO and PTX to trastuzumab by exploiting simple conjugation chemistry. Read More

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http://dx.doi.org/10.1002/open.201900037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454217PMC

Tumor Lysis Syndrome: A Rare Complication of Chemotherapy for Metastatic Breast Cancer.

Cureus 2019 Feb 7;11(2):e4024. Epub 2019 Feb 7.

Internal Medicine, Seton Hall University / Hackensack Meridian School of Medicine, Trenton, USA.

Tumor lysis syndrome (TLS) is a fatal complication of chemotherapy treatment. It is rarely seen in the treatment of solid tumors particularly in breast cancer. We presented the case of a chemo-naïve 58-year-old Caucasian woman who developed tumor lysis syndrome (TLS) after a single treatment dose of gemcitabine for metastatic breast cancer. Read More

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http://dx.doi.org/10.7759/cureus.4024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453617PMC
February 2019

Cerebral Sinus Venous Thrombosis in the Setting of Acute Mastoiditis.

Cureus 2019 Feb 6;11(2):e4023. Epub 2019 Feb 6.

Internal Medicine, University of Connecticut, Farmington, USA.

Cerebral sinus venous thrombosis (CSVT) is a rare complication of acute mastoiditis with a declining incidence in the post-antibiotic era. In the adult population its incidence ranges from three to four cases per million. Here we present a case of a 47-year-old female with triple negative breast cancer on chemotherapy who underwent a molar tooth extraction, which was followed two weeks later by the sudden onset of left-sided frontotemporal headache radiating down the face, left ear fullness with associated hearing loss, toothache, and left orbital pain. Read More

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https://www.cureus.com/articles/16460-cerebral-sinus-venous-
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http://dx.doi.org/10.7759/cureus.4023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453619PMC
February 2019
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Secretory Carcinoma of the Parotid: Making the Correct Diagnosis of a Rare Salivary Gland Carcinoma When Molecular Biology Testing Is Not Available.

Case Rep Pathol 2019 17;2019:5103496. Epub 2019 Mar 17.

Servicio de Patología, Hospital Metropolitano, Ecuador.

Secretory carcinoma (SC) is a recently described entity occurring in the salivary glands. Before its description, SC was frequently classified as acinic cell carcinoma (ACC) or adenocarcinoma, not otherwise specified. Its particular histopathological and immunohistochemical characteristics are reminiscent of breast secretory carcinoma. Read More

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http://dx.doi.org/10.1155/2019/5103496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441535PMC

Granular cell tumour of the breast: A rare presentation of a breast mass in an elderly female with a subsequent breast cancer diagnosis.

SAGE Open Med Case Rep 2019 9;7:2050313X19841154. Epub 2019 Apr 9.

Department of the Health of Woman, Child and Urological Diseases, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

A 74-year-old female patient presented with a hard breast mass and dimpling with a clinical suspicion of a carcinoma. Histological evaluation revealed a granular cell tumour. Granular cell tumour is a rare neoplasm, mostly benign in origin that may arise in every body site, 5%-15% of cases occur in the breast. Read More

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http://dx.doi.org/10.1177/2050313X19841154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457014PMC

Dual inhibition of ABCE1 and LCP1 by microRNA-96 results in an additive effect in breast cancer mouse model.

Oncotarget 2019 Mar 12;10(21):2086-2094. Epub 2019 Mar 12.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of target genes at the post-transcriptional level. Each miRNA can modulate multiple genes and, as a result, a single miRNA may have a profound effect on a specific biological pathway consisting of several of its target genes. Recent studies have indicated that specific miRNA signatures are correlated with tumor aggressiveness and clinical outcome in breast cancer. Read More

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http://dx.doi.org/10.18632/oncotarget.26747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459344PMC

HIGH expression of OSM and IL-6 are associated with decreased breast cancer survival: synergistic induction of IL-6 secretion by OSM and IL-1β.

Oncotarget 2019 Mar 12;10(21):2068-2085. Epub 2019 Mar 12.

Boise State University, Biomolecular Sciences Program, Boise, ID, USA.

Chronic inflammation has been recognized as a risk factor for the development and maintenance of malignant disease. Cytokines such as interleukin-6 (IL-6), oncostatin M (OSM), and interleukin-1 beta (IL-1β) promote the development of both acute and chronic inflammation while promoting metrics of breast cancer metastasis. However, anti-IL-6 and anti-IL-1β therapeutics have not yielded significant results against solid tumors in clinical trials. Read More

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http://dx.doi.org/10.18632/oncotarget.26699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459341PMC