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Trastuzumab Emtansine (T-DM1) Plus S-1 in Patients with Trastuzumab-Pretreated HER2-Positive Advanced or Metastatic Breast Cancer: A Phase Ib Study.

Oncology 2019 Mar 20:1-9. Epub 2019 Mar 20.

Division of Breast and Endocrine Surgery, Department of Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.

Background: In treating human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer, the efficacy of capecitabine combined with HER2-directed agents such as trastuzumab and lapatinib is supported by some evidence. The combination of T-DM1 and S-1, another oral 5-FU, may be a safe alternative treatment for metastatic breast cancer.

Objectives: The optimal dose of S-1 was evaluated in combination with T-DM1 for patients with HER2-positive advanced or metastatic breast cancer. Read More

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http://dx.doi.org/10.1159/000497276DOI Listing

Rapid Drug Desensitization with Chemotherapeutics (Platins, Taxanes, and Others): A Single-Center Retrospective Study.

Int Arch Allergy Immunol 2019 Mar 20:1-9. Epub 2019 Mar 20.

Background: Rapid drug desensitization (RDD) induces a temporary tolerance to chemotherapeutics that induce hypersensitivity reactions (HSRs).

Purpose: Our objective is to report our experience with RDD to platins, taxanes, etoposide, doxorubicin, and irinotecan.

Methods: The study was conducted as a retrospective chart review of patients with symptoms of HSRs to chemotherapeutics. Read More

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http://dx.doi.org/10.1159/000496745DOI Listing

Fine-Needle Aspiration Biopsy Management of the Axilla in Primary Breast Carcinoma.

Acta Cytol 2019 Mar 20:1-5. Epub 2019 Mar 20.

Pathology Department, St. Vincent's University Hospital, Dublin, Ireland.

Context: Fine-needle aspiration biopsy (FNAB) is frequently used to stage the axilla preoperatively in patients with primary breast carcinoma. In the light of the ACOSOG-Z0011 and AMAROS trials that specified sentinel lymph node biopsy as an inclusion criterion, the role of FNAB in axillary staging is changing.

Objective: This article will review the diagnostic accuracy of FNAB in staging of the axilla in patients with primary breast carcinoma. Read More

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http://dx.doi.org/10.1159/000496159DOI Listing

Chemotherapy Modulates Endocrine Therapy-Related Resistance Mutations in Metastatic Breast Cancer.

Transl Oncol 2019 Mar 17;12(5):764-774. Epub 2019 Mar 17.

The Affiliated Cancer Hospital of Xiangya Medical School, Central South University / Hunan Cancer Hospital, Changsha, 410013, China; Department of Breast Cancer Medical Oncology, Hunan Cancer Hospital, Changsha, 410013, China; Department of Breast Cancer Medical Oncology, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha 410013, China. Electronic address:

Purpose: Accumulation of PIK3CA, ESR1, and GATA3 mutations results in resistance to endocrine therapy in breast cancer patients; however, the response of these genes to chemotherapy is unclear. Therefore, we sought to evaluate the genetic response of circulating tumor DNA (ctDNA) to chemotherapy in metastatic breast cancer patients.

Methods: The mutation frequency of 1021 genes was examined prior to chemotherapy in ctDNA of 44 estrogen receptor-positive metastatic breast cancer patients. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.02.014DOI Listing

DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination.

Cell Rep 2019 Mar;26(12):3323-3335.e4

Department of Internal Medicine, Virginia Commonwealth University (VCU), Richmond, VA, USA; VCU Massey Cancer Center, VCU, Richmond, VA, USA. Electronic address:

The control of p53 protein stability is critical to its tumor suppressor functions. The CREB binding protein (CBP) transcriptional co-activator co-operates with MDM2 to maintain normally low physiological p53 levels in cells via exclusively cytoplasmic E4 polyubiquitination activity. Using mass spectrometry to identify nuclear and cytoplasmic CBP-interacting proteins that regulate compartmentalized CBP E4 activity, we identified deleted in breast cancer 1 (DBC1) as a stoichiometric CBP-interacting protein that negatively regulates CBP-dependent p53 polyubiquitination, stabilizes p53, and augments p53-dependent apoptosis. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.02.076DOI Listing

Quantitative Assessment of Breast Density Using Transmission Ultrasound Tomography.

Med Phys 2019 Mar 20. Epub 2019 Mar 20.

Chief Technology Officer, QT Ultrasound, LLC, 3 Hamilton Landing, Suite 160, Novato, CA, 94949.

Purpose: Breast density is important in the evaluation of breast cancer risk. At present, breast density is evaluated using two-dimensional projections from mammography with or without tomosynthesis using either (1) subjective assessment, or (2) a computer-aided approach. The purpose of this work is two-fold: (1) to establish an algorithm for quantitative assessment of breast density using quantitative three-dimensional transmission ultrasound imaging; and (2) to determine how these quantitative assessments compare with both subjective and objective mammographic assessments of breast density. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mp.13503
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http://dx.doi.org/10.1002/mp.13503DOI Listing
March 2019
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Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment.

PLoS Genet 2019 Mar 20;15(3):e1008002. Epub 2019 Mar 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.

Mammary epithelial progenitors are the normal cell-of-origin of breast cancer. We previously defined a population of p27+ quiescent hormone-responsive progenitor cells in the normal human breast whose frequency associates with breast cancer risk. Here, we describe that deletion of the Cdkn1b gene encoding the p27 cyclin-dependent kinase inhibitor in the estrogen-induced mammary tumor-susceptible ACI rat strain leads to a decrease in the relative frequencies of Cd49b+ mammary luminal epithelial progenitors and pregnancy-related differentiation. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008002DOI Listing

Integration of breast cancer prevention and early detection into cancer palliative care model.

PLoS One 2019 20;14(3):e0212806. Epub 2019 Mar 20.

Discipline of Nursing, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa.

Background: Breast cancer is common among Ghanaian women. Late stage presentation has been credited to knowledge deficit and lack of breast cancer prevention and early detection services for women.

Objective: This study aimed to develop a model to facilitate the integration of breast cancer prevention and early detection into cancer palliative care. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212806PLOS

Adherence of Mexican physicians to clinical guidelines in the management of breast cancer: Effect of the National Catastrophic Health Expenditure Fund.

PLoS One 2019 20;14(3):e0212841. Epub 2019 Mar 20.

Center for Population Health Research, National Institute of Public Health, Cuernavaca, Morelos, Mexico.

Aim: To assess the adherence of physicians to the Medical-Care Guidelines for Malignant Breast Tumors in Mexico, before and after the allocation of federal subsidies from the Catastrophic Health Expenditure Fund (FPGC by its Spanish initials) to accredited hospitals, a strategy implemented with the view of offering free treatment to women with breast cancer (BC).

Material And Methods: Based on a cross-sectional design, we gathered information on 479 BC patients who had been attended to at in four FPGC-accredited hospitals. Analysis centered on those treated within either three years before or three years after the accreditation of their attending hospitals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212841PLOS

ZnT2 is an electroneutral proton-coupled vesicular antiporter displaying an apparent stoichiometry of two protons per zinc ion.

PLoS Comput Biol 2019 Mar 20;15(3):e1006882. Epub 2019 Mar 20.

The Fred Wyszkowski Cancer Research Laboratory, Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel.

Zinc is a vital trace element crucial for the proper function of some 3,000 cellular proteins. Specifically, zinc is essential for key physiological processes including nucleic acid metabolism, regulation of gene expression, signal transduction, cell division, immune- and nervous system functions, wound healing, and apoptosis. Consequently, impairment of zinc homeostasis disrupts key cellular functions resulting in various human pathologies. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006882DOI Listing

Defining the immunogram of breast cancer: a focus on clinical trials.

Expert Opin Biol Ther 2019 Mar 20. Epub 2019 Mar 20.

a Division of Early Drug Development for Innovative Therapy , IEO, European Institute of Oncology IRCCS , Milan , Italy.

In the phase III ImPassion130 trial the addition of immunotherapy to chemotherapy improved overall survival in mTNBC patients. This benefit was significant only in patients harboring PD-L1-positive tumors, suggesting that stratification according to response biomarkers is needed to achieve consistent responses. Besides PD-L1 expression, a variety of potential biomarkers are under investigation for predicting immunotherapy efficacy in breast cancer, such as tumor-infiltrating lymphocytes, gene signatures, tumor mutational burden, microsatellite instability and gut microbiome. Read More

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http://dx.doi.org/10.1080/14712598.2019.1598372DOI Listing

ABM Clinical Protocol #30: Breast Masses, Breast Complaints, and Diagnostic Breast Imaging in the Lactating Woman.

Breastfeed Med 2019 Mar 20. Epub 2019 Mar 20.

3 Department of Family and Community Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols, free from commercial interest or influence, for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. Read More

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http://dx.doi.org/10.1089/bfm.2019.29124.kjmDOI Listing

Repeatability and Reproducibility of 3D MR Fingerprinting Relaxometry Measurements in Normal Breast Tissue.

J Magn Reson Imaging 2019 Mar 20. Epub 2019 Mar 20.

Department of Radiology, Case Western Reserve University, Cleveland, Ohio, USA.

Background: The 3D breast magnetic resonance fingerprinting (MRF) technique enables T and T mapping in breast tissues. Combined repeatability and reproducibility studies on breast T and T relaxometry are lacking.

Purpose: To assess test-retest and two-visit repeatability and interscanner reproducibility of the 3D breast MRF technique in a single-institution setting. Read More

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http://dx.doi.org/10.1002/jmri.26717DOI Listing

Attachment Styles, Self-Compassion, and Psychological Adjustment in Long-Term Breast Cancer Survivors.

Psychooncology 2019 Mar 20. Epub 2019 Mar 20.

Westmead Breast Cancer Institute, Westmead Hospital, Sydney.

Objective: The increasing numbers of breast cancer survivors highlight the importance of delineating factors that identify women who are at risk of poor psychological adjustment in the long term. In breast cancer survivors, higher attachment anxiety and attachment avoidance have been associated with poorer psychological adjustment. Moreover, there is evidence that self-compassion, a kind manner of treating oneself during difficulties, is associated with psychological distress in this population. Read More

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http://dx.doi.org/10.1002/pon.5068DOI Listing

Effect of younger age on survival outcomes in T1N0M0 breast cancer: A propensity score matching analysis.

J Surg Oncol 2019 Mar 20. Epub 2019 Mar 20.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation and Department of Breast Surgery, Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Purpose: We evaluated the effect of younger age on recurrence risk in Chinese women diagnosed with T1N0M0 breast cancer (BC), using propensity score matching (PSM) analysis.

Methods: We included 365 women who were diagnosed with T1N0M0 BC between 2003 and 2016, and who received surgery at our center. They were classified as younger (≤40 years) and older (>40 years). Read More

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http://dx.doi.org/10.1002/jso.25457DOI Listing

Prechemotherapy Levels of Plasma Dehydroepiandrosterone and Its Sulfated Form as Predictors of Cancer-Related Cognitive Impairment in Patients with Breast Cancer Receiving Chemotherapy.

Pharmacotherapy 2019 Mar 20. Epub 2019 Mar 20.

Department of Pharmacy, Faculty of Science, National University of Singapore.

Study Objective: Dehydroepiandrosterone (DHEA) and its sulfated form (DHEAS)-jointly referred as DHEA(S)-are neurosteroids known to regulate brain development and function that have been found to be positively correlated with cognitive function. It is unknown whether prechemotherapy plasma DHEA(S) levels are associated with the onset of cancer-related cognitive impairment (CRCI). The objective of this study was to evaluate whether an association exists between prechemotherapy plasma DHEA(S) levels and onset of CRCI in patients with breast cancer receiving chemotherapy. Read More

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http://dx.doi.org/10.1002/phar.2259DOI Listing

Concurrent neoadjuvant chemotherapy and estrogen deprivation in patients with estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer (CBCSG-036): A randomized, controlled, multicenter trial.

Cancer 2019 Mar 20. Epub 2019 Mar 20.

Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: The current randomized, controlled, multicenter clinical trial was conducted to investigate the efficacy of concurrent neoadjuvant chemotherapy (NCT) and estrogen deprivation in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer.

Methods: Eligible patients with AJCC stage IIB to stage IIIC, ER-positive, HER2-negative breast cancer were enrolled and randomly assigned to receive NCT with or without estrogen deprivation. The primary endpoint was the objective response rate (ORR). Read More

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http://dx.doi.org/10.1002/cncr.32057DOI Listing

Pituitary Metastases: a Nationwide Study on Current Characteristics with Special Reference to Breast Cancer.

J Clin Endocrinol Metab 2019 Mar 20. Epub 2019 Mar 20.

Department of Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.

Objective: To investigate the contemporary presentation of pituitary metastases.

Patients: Thirty-eight patients diagnosed with pituitary metastases 1996 to 2018 in Sweden.

Methods: Pituitary metastases were confirmed by histopathology (n = 27) or considered highly likely due to radiological findings, including rapid tumor progression (n = 11). Read More

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http://dx.doi.org/10.1210/jc.2019-00012DOI Listing

Pathologic Features and Clinical Implications of Breast Cancer With HER2 Intratumoral Genetic Heterogeneity.

Am J Clin Pathol 2019 Mar 20. Epub 2019 Mar 20.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

Objectives: To review breast cancer with human epidermal growth factor receptor 2 (HER2) genetic heterogeneity (GH), with a focus on clinician interpretation of the results and subsequent management.

Methods: We retrospectively searched all consecutive invasive breast cancers that underwent HER2 fluorescent in situ hybridization testing and identified cases with HER2 GH.

Results: Eleven (0. Read More

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http://dx.doi.org/10.1093/ajcp/aqz010DOI Listing

Origin-destination flows in chemotherapy for breast cancer in Brazil: implications for pharmaceutical services.

Cien Saude Colet 2019 Mar;24(3):1153-1164

Departamento de Políticas de Medicamentos e Assistência Farmacêutica, ENSP, Fiocruz. Rio de Janeiro RJ Brasil.

This study maps and analyzes patient flows for breast cancer chemotherapy in order to identify the potential implications for organization of pharmaceutical services in the cancer care network. An ecological study design sought to correlate the place of residence with place of care for breast cancer patients. All chemotherapy procedures financed by Brazil's Unified Health System (SUS) and performed from January to December 2013 were included. Read More

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http://dx.doi.org/10.1590/1413-81232018243.10272017DOI Listing

Efect of vitamin A suplementation: a systematic review.

Cien Saude Colet 2019 Mar;24(3):827-838

Ciência da Nutrição, Departamento de Nutrição e Saúde, Universidade Federal de Viçosa. Ed. Centro de Ciências Biológicas II Centro Universitário. 36570-000 Viçosa MG Brasil.

To evaluate the effect of vitamin A supplementation in postpartum infants and women on serum retinol levels and breast milk. The databases Medline, PubMed, Lilacs and SciELO were consulted. The descriptors used were vitamin A, dietary supplement, child, postpartum period, infant and nutrition programs policies. Read More

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http://dx.doi.org/10.1590/1413-81232018243.07112017DOI Listing

Patient satisfaction with breast reconstructionusing musculocutaneous flap from latissimus dorsiversus from rectus abdominis: a cross-sectional study.

Sao Paulo Med J 2018 Nov-Dec;136(6):551-556

MD, PhD. Physician and Titular Professor, Discipline of Plastic Surgery, Universidade Federal de São Paulo (UNİFESP), São Paulo (SP), Brazil.

Background: Breast cancer is the second most frequent type of cancer worldwide and the most common type among women. The treatment for this condition has evolved over recent decades with therapeutic and technological advances. Breast reconstruction techniques using musculocutaneous flaps from the latissimus dorsi and rectus abdominis have aroused interest regarding patients' quality of life. Read More

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http://dx.doi.org/10.1590/1516-3180.2018.032916112018DOI Listing
October 2018

Laser irradiation affects the biological identity and cellular uptake of plasmonic nanoparticles.

Nanoscale 2019 Mar 20. Epub 2019 Mar 20.

Department of Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran. and Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1417614411, Iran.

The biological identity of nanoparticles (NPs) is defined by a protein layer formed on their surface, called protein corona (PC), once they meet the biological milieu. Any change in the PC composition may influence the biological fate of NPs. The PC composition is strongly dependent on several parameters including the physicochemical properties of NPs, and biological and environmental factors. Read More

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http://dx.doi.org/10.1039/c8nr09622hDOI Listing

Crossbar-Net: A Novel Convolutional Neural Network for Kidney Tumor Segmentation in CT Images.

IEEE Trans Image Process 2019 Mar 18. Epub 2019 Mar 18.

Due to the unpredictable location, fuzzy texture and diverse shape, accurate segmentation of the kidney tumor in CT images is an important yet challenging task. To this end, we in this paper present a cascaded trainable segmentation model termed as Crossbar-Net. Our method combines two novel schemes: (1) we originally proposed the crossbar patches, which consists of two orthogonal non-squared patches (i. Read More

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http://dx.doi.org/10.1109/TIP.2019.2905537DOI Listing

Perspectives on the mechanism of action and clinical application of eribulin for metastatic breast cancer.

Future Oncol 2019 Mar 20. Epub 2019 Mar 20.

Columbia University Irving Medical Center, NY, USA.

Eribulin is a novel microtubule inhibitor with mitotic and nonmitotic mechanisms of action. Both pooled and subgroup analyses from large-scale Phase III clinical trials demonstrated that eribulin has substantial activity in patients with pretreated (anthracycline and a taxane) advanced or metastatic breast cancer. We review recent pharmacological and clinical findings pertaining to eribulin use in metastatic breast cancer - particularly highlighting eribulin in difficult-to-treat and aggressive disease, and safety data in specific patient populations. Read More

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http://dx.doi.org/10.2217/fon-2018-0936DOI Listing

[Seroepidemiological survey of infection in patients with gynecological malignant tumors].

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi 2019 Feb;30(6):682-684

Wuxi No. 9 People's Hospital, Wuxi Municipal Orthopedic Hospital, Jiangsu Province, Wuxi 214000, China.

Objective: To investigate the seroprevalence of infection in patients with gynecological malignant tumors, so as to provide the evidence for the control of infections in the patients with gynecological malignant tumors.

Methods: A total of 327 patients with gynecological malignant tumors were recruited, and 200 women with normal healthy examinations were served as controls. The serum anti- IgG and IgM antibodies were detected by using ELISA, and the seroprevalence was compared between the patients and controls, and among various types of cancers. Read More

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http://dx.doi.org/10.16250/j.32.1374.2019036DOI Listing
February 2019

Successful treatment of breast cancer-related breast lymphedema by lymphovenous anastomosis in a male patient.

Microsurgery 2019 Mar 19. Epub 2019 Mar 19.

International Lymphedema Center, Hiroshima University Hospital, Hiroshima, Japan.

Men, as well as women may develop breast lymphedema following breast cancer treatment. Microsurgically performed lymphovenous anastomosis (LVA), an effective treatment for lymphedema of the extremities, has also been successfully applied to breast lymphedema. Here we report the first case of breast lymphedema secondary to male breast cancer, treated with supermicrosurgical LVA. Read More

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http://dx.doi.org/10.1002/micr.30447DOI Listing

Synthesis and anti-breast cancer activity of novel indibulin related diarylpyrrole derivatives.

Daru 2019 Mar 20. Epub 2019 Mar 20.

Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design & Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, 1417614411, Iran.

Background: During recent years, a number of anti-tubulin agents were introduced for treatment of diverse types of cancer. Despite their potential in the treatment of cancer, drug resistance and adverse toxicity, such as peripheral neuropathy, are some of the negative effects of anti-tubulin agents. Among anti-tubulin agents, indibulin was found to cause minimal peripheral neuropathy. Read More

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http://dx.doi.org/10.1007/s40199-019-00260-9DOI Listing

Combined Breast Reduction Augmentation.

Aesthetic Plast Surg 2019 Mar 19. Epub 2019 Mar 19.

Division of Plastic Surgery, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 4500 San Pablo Rd, Jacksonville, FL, 32224, USA.

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http://dx.doi.org/10.1007/s00266-019-01350-4DOI Listing

Role of transporters in the disposition of a novel β-lactamase inhibitor: relebactam (MK-7655).

J Antimicrob Chemother 2019 Mar 19. Epub 2019 Mar 19.

Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM), Merck & Co., Inc., Kenilworth, NJ, USA.

Objectives: To identify the transporters involved in renal elimination of relebactam, and to assess the potential of relebactam as a perpetrator or victim of drug-drug interactions (DDIs) for major drug transporters.

Methods: A series of bidirectional transport, uptake and inhibition studies were conducted in vitro using transfected cell lines and membrane vesicles. The inhibitory effects of relebactam on major drug transporters, as well as the inhibitory effects of commonly used antibiotics/antifungals on organic anion transporter (OAT) 3-mediated uptake of relebactam, were assessed. Read More

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http://dx.doi.org/10.1093/jac/dkz101DOI Listing

Long non-coding RNAs: Functional regulatory players in breast cancer.

Noncoding RNA Res 2019 Mar 5;4(1):36-44. Epub 2019 Feb 5.

Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835, Cairo, Egypt.

Historically, the long-held protein-centered bias has denoted 98% of the human genome as 'Junk' DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional regulatory molecules. The recent surveillance of the human transcriptome has highlighted the pivotal role of such non-coding RNA (ncRNA) molecules in diverse physiological and pathological conditions. Read More

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http://dx.doi.org/10.1016/j.ncrna.2019.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404363PMC

Is Socioeconomic Advantage Associated With Positive Health Behaviors and Health Outcomes Among Asian Indians?

Health Serv Res Manag Epidemiol 2019 Jan-Dec;6:2333392819830371. Epub 2019 Mar 13.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Objective: The South Asian Health Needs Assessment was conducted to collect health status information on the rapidly growing Asian Indian (AI) community in the Houston area. Many were highly educated and reported high income levels, factors usually associated with better health outcomes. This study examined the relationship between socioeconomic advantage and the health behaviors and health outcomes of AIs. Read More

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http://dx.doi.org/10.1177/2333392819830371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416674PMC

Classification of breast microcalcifications using dual-energy mammography.

J Med Imaging (Bellingham) 2019 Jan 12;6(1):013502. Epub 2019 Mar 12.

U.S. Food and Drug Administration, CDRH, Division of Imaging Diagnostics and Software Reliability, Silver Spring, Maryland, United States.

The potential of dual-energy mammography for microcalcification classification was investigated with simulation and phantom studies. Classification of type I/II calcifications was performed using the tissue attenuation ratio as a performance metric. The simulation and phantom studies were carried out using breast phantoms of 50% fibroglandular and 50% adipose tissue composition and thicknessess ranging from 3 to 6 cm. Read More

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http://dx.doi.org/10.1117/1.JMI.6.1.013502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411940PMC
January 2019

Comparative Diagnostic Accuracy of Contrast-Enhanced Ultrasound and Shear Wave Elastography in Differentiating Benign and Malignant Lesions: A Network Meta-Analysis.

Front Oncol 2019 5;9:102. Epub 2019 Mar 5.

Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

We performed a network meta-analysis to compare the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) and shear wave elastography (SWE) in differentiating benign and malignant lesions in different body sites. A computerized literature search of Medline, Embase, SCOPUS, and Web of Science was performed using relevant keywords. Following data extraction, we calculated sensitivity, specificity, positive likelihood ratio (LR), negative LR, and diagnostic odds ratio (DOR) for CEUS, and SWE compared to histopathology as a reference standard. Read More

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http://dx.doi.org/10.3389/fonc.2019.00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412152PMC

Ambulatory Toxicity Management (AToM) Pilot: results of a pilot study of a pro-active, telephone-based intervention to improve toxicity management during chemotherapy for breast cancer.

Pilot Feasibility Stud 2019 8;5:39. Epub 2019 Mar 8.

1Cancer Care Ontario, Toronto, ON Canada.

Background: Chemotherapy is associated with a significant risk of toxicity, which often peaks between ambulatory visits to the cancer centre. Remote symptom management support is a tool to optimize self-management and healthcare utilization, including emergency department visits and hospitalizations (ED+H) during chemotherapy. We performed a single-arm pilot study to evaluate the feasibility, acceptability, and potential impact of a telephone symptom management intervention on healthcare utilization during chemotherapy for early stage breast cancer (EBC). Read More

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http://dx.doi.org/10.1186/s40814-019-0404-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407231PMC

Unexpected destination! Rectal carcinoma metastasis to breast.

J Surg Case Rep 2019 Mar 14;2019(3):rjz036. Epub 2019 Mar 14.

Department of Surgery, Letterkenny University Hospital Letterkenny, County Donegal, Ireland.

Rectal cancer metastasis to the breast is rare with around 19 cases reported in literature. It signifies diffuse disseminated disease or highly aggressive tumour, such that surgical intervention other than palliation has a limited role. We report a case of a 43-year-old with the above presentation. Read More

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http://dx.doi.org/10.1093/jscr/rjz036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416825PMC

Relapsed multiple myeloma manifesting as extramedullary plasmacytoma of the breast: Imaging findings.

Radiol Case Rep 2019 May 5;14(5):584-587. Epub 2019 Mar 5.

Department of Radiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuhocho, Mizuho-ku, Nagoya, Japan.

Extramedullary plasmacytoma of the breast (EPB), a manifestation of multiple myeloma (MM), is very rare. It is important to recognize the imaging findings of EPB because it may be the first manifestation of relapsed MM. An 85-year-old woman presented with a lump in her right breast 4 years after the complete remission of MM. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406076PMC

Presence of Circulating miR-145, miR-155, and miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors.

Dis Markers 2019 12;2019:6852917. Epub 2019 Feb 12.

Universidad Autónoma de Nuevo León, College of Biological Sciences, Department of Cellular Biology and Genetics, San Nicolás de los Garza, Nuevo León, Mexico.

miR-145, miR-155, and miR-382 have been proposed as noninvasive biomarkers to distinguish breast cancer patients from healthy individuals. However, it is unknown if these three miRNAs are secreted by exosomes. Thus, we hypothesized that miR-145, miR-155, and miR-382 in breast cancer patients are present in exosomes. Read More

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http://dx.doi.org/10.1155/2019/6852917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390256PMC
February 2019

The Precautionary Principle for Shift-Work Research and Decision-Making.

Public Health Ethics 2019 Apr 12;12(1):44-53. Epub 2018 Mar 12.

Department of Bioethics and Humanities, University of Washington.

Shift work (working outside of 6:00 AM to 6:00 PM) is a fixture of our 24-hour economy, with approximately 18 per cent of workers in the USA engaging in shift work, many overnight. Since shift work has been linked to an increased risk for an array of serious maladies, including cardiometabolic disorders and cancer, and is done disproportionately by the poor and by minorities, shift work is a highly prevalent economic and occupational health disparity. Here we draw primarily on the state of science around shift work and breast cancer to argue that shift work represents a public health threat serious enough to warrant a precautionary stance. Read More

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http://dx.doi.org/10.1093/phe/phy005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415719PMC

Inhibitors of Human ABCG2: From Technical Background to Recent Updates With Clinical Implications.

Front Pharmacol 2019 5;10:208. Epub 2019 Mar 5.

Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

The ATP-binding cassette transporter G2 (ABCG2; also known as breast cancer resistance protein, BCRP) has been suggested to be involved in clinical multidrug resistance (MDR) in cancer like other ABC transporters such as ABCB1 (-glycoprotein). As an efflux pump exhibiting a broad substrate specificity localized on cellular plasma membrane, ABCG2 excretes a variety of endogenous and exogenous substrates including chemotherapeutic agents, such as mitoxantrone and several tyrosine kinase inhibitors. Moreover, in the normal tissues, ABCG2 is expressed on the apical membranes and plays a pivotal role in tissue protection against various xenobiotics. Read More

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http://dx.doi.org/10.3389/fphar.2019.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411714PMC

Curcumin Nanoformulations for Colorectal Cancer: A Review.

Front Pharmacol 2019 5;10:152. Epub 2019 Mar 5.

Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia.

Colorectal cancer (CRC) is the third most prevalent form of cancer, after lung cancer and breast cancer, with the second highest death incidence. Over the years, natural compounds have been explored as an alternative to conventional cancer therapies such as surgery, radiotherapy, and chemotherapy. Curcumin, an active constituent of turmeric has been associated with various health benefits. Read More

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http://dx.doi.org/10.3389/fphar.2019.00152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412150PMC

Relationships between the weaning period and the introduction of complementary foods in the transmission of gastrointestinal parasitic infections in children in Honduras.

Res Rep Trop Med 2018 26;9:113-122. Epub 2018 Jul 26.

Department of Microbiology and Immunology,

Purpose: This study was to investigate weaning practices used by mothers when transitioning infants from breast milk to complementary foods and to determine the role these foods have in the transmission of gastrointestinal parasites.

Participants And Methods: On average, of the 175 mothers extensively interviewed, 93% said they had breast-fed their infants. Approximately 20. Read More

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http://dx.doi.org/10.2147/RRTM.S160388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065550PMC

Lung cancer in Pakistan, where do we stand?

J Pak Med Assoc 2019 Mar;69(3):405-408

General Physician, Cantonment Board Hospital.

Lung cancer is the most common cancer in males and second most common in females after breast cancer. We have compared our data with the international statistics to see where do we stand. In Pakistan, we do not have a valid central cancer registry at present which can provide a true picture of lung cancer. Read More

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Serious adverse events in African-American cancer patients with sickle cell trait and inherited haemoglobinopathies in a SEER-Medicare claims cohort.

Br J Cancer 2019 Mar 20. Epub 2019 Mar 20.

Department of Community Medicine and Health Care, UConn School of Medicine, Farmington, CT, USA.

African-American (AA) cancer patients have long-experienced worse outcomes compared to non-Hispanic whites (NHW). No studies to date have evaluated the prognostic impact of sickle cell trait (SCT) and other inherited haemoglobinopathies, of which several are disproportionately high in the AA population. In a cohort analysis of treated patients diagnosed with breast or prostate cancer in the linked SEER-Medicare database, the relative risk (RR) for ≥1 serious adverse events (AEs), defined as hospitalisations or emergency department visits, was estimated for 371 AA patients with a haemoglobinopathy (AA+) compared to patients without haemoglobinopathies (17,303 AA-; 144,863 NHW-). Read More

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http://dx.doi.org/10.1038/s41416-019-0416-7DOI Listing

Hypercalcemia in Metaplastic Squamous Cell Carcinoma of the Breast.

Am J Case Rep 2019 Mar 20;20:366-369. Epub 2019 Mar 20.

Division of Surgical Oncology, Rush University Medical Center, Chicago, IL, USA.

BACKGROUND Metaplastic breast carcinoma is a rare entity characterized by rapid growth and heterogeneous histological features. It comprises less than 1% of all breast cancers, and no definitive treatment has yet been identified. CASE REPORT We describe here a patient who presented with acute hypercalcemia and was found to have a large ulcerated breast mass. Read More

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http://dx.doi.org/10.12659/AJCR.912427DOI Listing

ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis.

Proc Natl Acad Sci U S A 2019 Mar 19. Epub 2019 Mar 19.

Department of Biochemistry, University of Missouri, Columbia, MO 65211;

Lysyl oxidase (LOX) and LOX-like (LOXL) proteins are copper-dependent metalloenzymes with well-documented roles in tumor metastasis and fibrotic diseases. The mechanism by which copper is delivered to these enzymes is poorly understood. In this study, we demonstrate that the copper transporter ATP7A is necessary for the activity of LOX and LOXL enzymes. Read More

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http://dx.doi.org/10.1073/pnas.1817473116DOI Listing

Alternative splicing and ACMG-AMP-2015-based classification of PALB2 genetic variants: an ENIGMA report.

J Med Genet 2019 Mar 19. Epub 2019 Mar 19.

Laboratorio Oncología Molecular, Hospital Clínico San Carlos, Madrid, Spain.

Background: monoallelic germ-line variants confer a breast cancer risk comparable to the average pathogenic variant. Recommendations for risk reduction strategies in carriers are similar. Elaborating robust criteria to identify variants in without incurring overprediction-is thus of paramount clinical relevance. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105834DOI Listing

Breast phyllodes tumors recruit and repolarize tumor-associated macrophages via secreting CCL5 to promote malignant progression which can be inhibited by CCR5 inhibition Therapy.

Clin Cancer Res 2019 Mar 19. Epub 2019 Mar 19.

Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University.

Purpose: Our previous studies have shown that the high density of tumor associated macrophage (TAM) plays an important role in the malignant progression of PTs. However, the mechanism by which TAMs are recruited and repolarized by PTs to drive the malignant progression remains unclear.

Experimental Design: The primary PT cells and TAMs were isolated from the human breast phyllodes tumor tissues for in vitro and in vivo experimens. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3421DOI Listing

Sex hormones and anticancer immunity.

Clin Cancer Res 2019 Mar 19. Epub 2019 Mar 19.

Department of Biochemistry, University of Lausanne.

The impact of sex hormones on anticancer immunity deserves attention due to the importance of the immune system in cancer therapy and the recognition of sex differences in immunity. Cancer is ultimately the result of failed immune surveillance and diverging effects of male and female sex hormones on anticancer immunity could contribute to the higher cancer incidence and poorer outcome in men. Estrogens and androgens affect the number and function of immune cells, an effect that depends on cell type, tumor microenvironment, and the age and reproductive status of the individual. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0137DOI Listing

Polo-like Kinase 1 inhibition as a therapeutic approach to selectively target BRCA1-deficient cancer cells by synthetic lethality induction.

Clin Cancer Res 2019 Mar 19. Epub 2019 Mar 19.

CIBICI-CONICET, Department of clinical biochemistry, National University of Córdoba

Purpose: BRCA1 and BRCA2-deficiencies are widespread drivers of human cancers that await the development of targeted therapies. We aimed to identify novel synthetic lethal relationships with therapeutic potential using BRCA-deficient isogenic backgrounds.

Experimental Design: We developed a phenotypic screening technology to simultaneously search for synthetic lethal (SL) interactions in BRCA1 and BRCA2-deficient contexts. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3516DOI Listing