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Prevalence of breast fibroadenoma in healthy physical examination population in Guangdong province of China: a cross-sectional study.

BMJ Open 2022 Jun 27;12(6):e057080. Epub 2022 Jun 27.

Breast Center, Department of general surgery, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China

Objective: To provide an accurate assessment of the prevalence of breast fibroadenoma in a large population and to confirm the diagnostic accuracy of ultrasound for fibroadenoma.

Design: This was a cross-sectional survey.

Setting: This research was conducted at Nanfang Hospital, Guangzhou, Guangdong, China. Read More

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The impact of COVID-19 on the screening of colorectal, gastric, breast and cervical cancer in Korea.

Epidemiol Health 2022 Jun 21:e2022053. Epub 2022 Jun 21.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

Objectives: The COVID-19 pandemic has affected the utilization of healthcare services, such as participation in cancer screening programs. We compared cancer screening participation rates for colorectal, gastric, breast, and cervical cancers among participants in the National Cancer Screening Program (NCSP) in 2019 and 2020 to address the potential distraction effect of COVID-19 on cancer screening.

Methods: Data from the NCSP for four cancer types (stomach, colorectal, breast and cervical) in 2019 and 2020 were used to calculate cancer screening participation rates by calendar month, gender, age group, and geographical region. Read More

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The effect of equipotent dose of propofol and sevoflurane on endoplasmic reticulum stress during breast cancer surgery.

Korean J Anesthesiol 2022 Jun 28. Epub 2022 Jun 28.

Department of Anesthesiology and Pain Medicine, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, Korea.

Background: Numerous studies suggest a benefit of the use of intravenous propofol over inhalational volatile anesthetic. The objective of this study was to compare the changes in endoplasmic reticulum (ER) stress of cancer cells and lymphocytes after propofol- or sevoflurane-based anesthesia during breast cancer surgery.

Methods: A total of 53 patients having breast cancer surgery were randomized and analyzed (28 for propofol, 25 for sevoflurane). Read More

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Evaluation of prenatal breastfeeding workshop to inform and support mother with antenatal diagnosis of cleft lip/palate.

J Stomatol Oral Maxillofac Surg 2022 Jun 24. Epub 2022 Jun 24.

Department of Maxillo-facial and Plastic Surgery, Necker-Enfants Malades Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; facial cleft and malformation national network, Paris, France; University of Paris, France. Electronic address:

Introduction: To support mother with antenatal diagnosis of cleft lip/palate (CL/P), we implement an antenatal breastfeeding workshop to promote breastfeeding and its continuation. The aim of this study was to evaluate patient satisfaction after this workshop and efficiency of this workshop on breastfeeding rates and duration.

Materials And Methods: We conducted a prospective study from February 2018 to April 2022. Read More

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Aptamer-conjugated nano-liposome for immunogenic chemotherapy with reversal of immunosuppression.

J Control Release 2022 Jun 24. Epub 2022 Jun 24.

Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of Korea. Electronic address:

Cancer cells have various immune evasion mechanisms that resist the immune cells by reprogramming the tumor microenvironment (TME), such as programmed death-ligand 1 (PD-L1) and indoleamine 2,3-dioxygenase-1 (IDO1) overexpression. One of the approaches to restore antitumor immune response by T-cells is through induction of immunogenic cell death (ICD). Thus, drug carrier containing IDO1 siRNA and ICD inducer would be effective anticancer regimen to modulate the immunosuppressive TME by reversing the IDO1-mediated immunosuppression in a synergistic combination with ICD induction. Read More

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OTSSP167 leads to follicular dysplasia and negatively affects oocyte quality in mice.

Toxicology 2022 Jun 24:153243. Epub 2022 Jun 24.

Fertility Preservation Lab, Guangdong-Hong Kong Metabolism & Reproduction Joint Laboratory, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China. Electronic address:

OTSSP167 is an anti-tumor drug significantly inhibiting tumor growth in xenotransplantation studies using mouse breast, lung, prostate, and pancreatic cancer cell lines. Its phase I clinical trial has been completed, indicating its great potential for future treatment of solid tumors. However, its drug-related adverse effects on reproductive systems have not yet been reported. Read More

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Polycyclic aromatic hydrocarbons in breast milk of nursing mothers: Correlates with household fuel and cooking methods used in Uganda, East Africa.

Sci Total Environ 2022 Jun 24:156892. Epub 2022 Jun 24.

Department of Chemistry, College of Natural Sciences, Makerere University, P. O. Box 7062, Kampala, Uganda; Department of Analytical Environmental Chemistry, Helmholtz Centre for Environmental Research-UFZ, D-04318 Leipzig, Germany. Electronic address:

Maternal breast milk, which is a complete food for the infant's growth, development, and health, contains fats and lipids making it susceptible to accumulation of lipophilic compounds like polycyclic aromatic hydrocarbons (PAHs). This study aimed at analyzing correlates of measured levels of PAHs in breast milk of nursing mothers to frequently used household fuels and cooking methods in Uganda, and estimate the potential health risks of PAHs to infants through breastfeeding. Sixty breast milk samples were collected from healthy and non-smoking mothers who had lived in Kampala capital city (urban area) and Nakaseke district (rural area) for at least five years. Read More

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CELL BLOCKS FROM ULTRASOUND GUIDED FINE NEEDLE ASPIRATES: DIAGNOSTIC YIELD IN A SERIES OF 51 DERMATOLOGIC LESIONS.

Actas Dermosifiliogr 2022 Jun 24. Epub 2022 Jun 24.

Dermatology Department Hospital Universitario Puerta de Hierro Majadahonda, Spain.

The generation of cell blocks (CB) obtained from ultrasound-guided fine needle aspiration biopsies (USFNAB) is a well-established technique in breast and thyroid pathology, but is rarely used in dermatology. We reviewed CBs obtained from USFNAB of skin lesions, which were categorized as malignant skin tumors, benign skin tumors, inflammatory skin tumors or deposit skin diseases. The diagnostic yield of each category was compared to histopathology. Read More

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Intraoperative Ultrasound-Guided Excision of Non-Palpable and Palpable Breast Cancer: Systematic Review and Meta-Analysis.

Ultraschall Med 2022 Jun 27. Epub 2022 Jun 27.

Department for Women's Health, University of Tübingen, Tübingen, Germany.

Wire-guided localization (WGL) is the most frequently used localization technique in non-palpable breast cancer (BC). However, low negative margin rates, patient discomfort, and the possibility of wire dislocation have been discussed as potential disadvantages, and re-operation due to positive margins may increase relapse risk. Intraoperative ultrasound (IOUS)-guided excision allows direct visualization of the lesion and the resection volume and reduces positive margins in palpable and non-palpable tumors. Read More

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Induction of P-glycoprotein expression by dandelion in tumor and heart tissues: Impact on the anti-tumor activity and cardiotoxicity of doxorubicin.

Phytomedicine 2022 Jun 12;104:154275. Epub 2022 Jun 12.

National and Local Joint Engineering Laboratory for Key Technology of Chinese Material Medica Quality Control, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Background: Previously, we have investigated the anti-tumor activity and mechanism through which dandelion acts against triple-negative breast cancer (TNBC). However, traditional Chinese medicine is mostly accepted as an adjunct therapy during chemotherapy in clinical practice. So far, little is known about the effects of dandelion in conjunction with chemotherapeutic drugs. Read More

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Corn distiller's dried grains with solubles as an alternative ingredient to corn and soybean meal in Pekin duck diets based on its predicted AME and the evaluated standardized ileal digestibility of amino acids.

Poult Sci 2022 May 21;101(8):101974. Epub 2022 May 21.

Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan, China; Key Laboratory for Animal Disease-Resistance Nutrition of, Ministry of Education, Ministry of Agriculture and Rural Affaires, Sichuan Province 611130, China. Electronic address:

The study aimed to investigate the effects of dietary distillers dried grains with solubles (DDGS) levels on growth performance, carcass characteristic, serum biochemical indexes, meat physical and chemical quality, nutrient utilization, and standardized ileal digestibility of amino acids (SIDAA) in Pekin ducks aged 11 to 42 d based on the evaluation of its SIDAA. A total of 560 eleven-day-old Cherry Valley ducks were randomly allotted to 5 treatments with 7 replicate pens per treatment and 16 ducks per pen based on the average body weight. Six isonitrogenous and isocaloric experimental diets were formulated on a digestible amino acid basis to produce diets containing 0, 5, 10, 15, and 20% DDGS, respectively. Read More

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Effects of early feeding of enzymatically treated yeast on growth performance, organ weights, intestinal histomorphology, and ceca microbial metabolites in broiler chickens subjected to Eimeria challenge.

Poult Sci 2022 May 21;101(8):101967. Epub 2022 May 21.

Livalta, AB Agri Ltd., Peterborough, Cambridgeshire, PE2 6FL, UK.

The study evaluated effects of early feeding of enzymatically treated yeast on growth performance and selected physiological responses in broiler chickens. A total of 480-day-old (male) Ross × Ross 708 broiler chicks were placed in 24 floor pens (20 birds per pen) and allocated to 2 diets (control vs. yeast) in a completely randomized block design (n = 12). Read More

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Walking Dead Tumor Cells for Targeted Drug Delivery Against Lung Metastasis of Triple Negative Breast Cancer.

Adv Mater 2022 Jun 27:e2205462. Epub 2022 Jun 27.

State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Lung metastasis is challenging in patients with triple-negative breast cancer (TNBC). Surgery is always not available due to the dissemination of metastatic foci and most of drugs are powerless because of poor retention at metastatic sites. TNBC cells generate inflamed microenvironment and overexpress adhesive molecules to promote the invasion and colonization. Read More

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Cytotoxic and antiparasitic activities of diphosphine-metal complexes of group 10 containing acylthiourea as ligands.

J Inorg Biochem 2022 Jun 20;234:111906. Epub 2022 Jun 20.

Departamento de Química, Universidade Federal de São Carlos - UFSCar, 3561-901 São Carlos, SP, Brazil. Electronic address:

In this work, group 10 transition metal complexes bearing dppe [1,2-bis(diphenylphosphino)ethane] and acylthiourea ligands were evaluated for their cytotoxic and antiparasitic activities. Six new complexes with a general formula [M(L)(dppe)]BF [where M = Ni, Pd or Pt; L = N, N'-dimethyl-N-benzoyl thiourea (L) or N, N'-dimethyl-N-tiofenyl thiourea (L) were synthesized and characterized by infrared, NMR (P{H}, H and C{H}) spectroscopies, elemental analysis and molar conductivity. The structures of the complexes were confirmed by X-ray diffraction technique. Read More

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New thiophene, thienopyridine and thiazoline-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents and multitargeting kinase inhibitors.

Bioorg Chem 2022 Jun 14;127:105964. Epub 2022 Jun 14.

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. Electronic address:

Multitargeting kinase inhibitors recently proved to be a profitable approach for conquering cancer proliferation. The current study represents the design and synthesis of new thiophene, thienopyridine, and thiazoline-based derivatives 4-14a,b. All the target compounds were examined in vitro against three cancer cell lines; the liver (HepG-2), breast (MCF-7), and colon (HCT-116) where the thiophene-based compounds 5a-c, demonstrated the most potent activity. Read More

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Multiple mediation analysis of racial disparity in breast cancer survival.

Cancer Epidemiol 2022 Jun 24;79:102206. Epub 2022 Jun 24.

Stetson University, Public Health Program, Deland, FL, USA.

Background: Racial (Black vs. White) disparities in breast cancer survival have proven difficult to mitigate. Targeted strategies aimed at the primary factors driving the disparity offer the greatest potential for success. Read More

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An immunological signature to predict outcome in patients with triple-negative breast cancer with residual disease after neoadjuvant chemotherapy.

ESMO Open 2022 Jun 24;7(4):100502. Epub 2022 Jun 24.

Univ. Bordeaux, INSERM U1218, ACTION Laboratory, Bordeaux, France; Biopathology, Institut Bergonié, Bordeaux, France. Electronic address:

Background: When triple-negative breast cancer (TNBC) patients have residual disease after neoadjuvant chemotherapy (NACT), they have a high risk of metastatic relapse. With immune infiltrate in TNBC being prognostic and predictive of response to treatment, our aim was to develop an immunologic transcriptomic signature using post-NACT samples to predict relapse.

Materials And Methods: We identified 115 samples of residual tumors from post-NACT TNBC patients. Read More

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Comparative efficacy and acceptability of cognitive behavioral therapy delivery formats for insomnia in adults: A systematic review and network meta-analysis.

Sleep Med Rev 2022 May 31;64:101648. Epub 2022 May 31.

Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China; Key Laboratory of Evidence-based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China. Electronic address:

This review compared the efficacy and acceptability of different delivery formats for cognitive behavioral therapy for insomnia (CBT-I) in insomnia. We searched five databases for randomized clinical trials that compared one CBT-I delivery format against another format or control conditions for insomnia in adults. We used pairwise meta-analyses and frequentist network meta-analyses with the random-effects model to synthesize data. Read More

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Tools for Contralateral Prophylactic Mastectomy Decision Making.

J Clin Oncol 2022 Jun 27:JCO2102782. Epub 2022 Jun 27.

Division of Surgical Oncology and Endocrine Surgery, University of Texas Health, San Antonio, TX.

Purpose: Women with unilateral breast cancer are increasingly opting for the removal of not only the involved breast, but also for the removal of the opposite uninvolved breast (contralateral prophylactic mastectomy [CPM]), although the risk of contralateral breast cancer (CBC) has decreased in recent years. Models to predict the absolute risk of CBC can help a woman decide whether to undergo CPM. Our objective is to illustrate that a better decision can be made if the patient and doctor also have estimates of the absolute risks of regional and distant recurrences and mortality from non-breast cancer causes. Read More

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Feasibility of ultrasound tomography-guided localized mild hyperthermia using ring transducer: Ex vivo and In silico studies.

Med Phys 2022 Jun 27. Epub 2022 Jun 27.

Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, 48202, USA.

Background: As of 2022, breast cancer continues to be the most diagnosed cancer worldwide. This problem persists within the U.S as well, as the American Cancer Society has reported that approximately 12. Read More

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Biomarkers for Systemic Therapy in Metastatic Breast Cancer: ASCO Guideline Update.

J Clin Oncol 2022 Jun 27:JCO2201063. Epub 2022 Jun 27.

University of Pennsylvania, Philadelphia, PA.

Purpose: To update the ASCO biomarkers to guide systemic therapy for metastatic breast cancer (MBC) guideline.

Methods: An Expert Panel conducted a systematic review to identify randomized clinical trials and prospective-retrospective studies from January 2015 to January 2022.

Results: The search identified 19 studies informing the evidence base. Read More

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Volatile versus propofol general anesthesia and long-term survival after breast cancer surgery: a national registry retrospective cohort study.

Anesthesiology 2022 Jun 28. Epub 2022 Jun 28.

Uppsala University, Center for Clinical Research, Västerås, Sweden.

Background: Several retrospective studies using administrative or single center data have failed to show any difference between general anesthesia using propofol versus inhaled volatiles on long-term survival after breast cancer surgery. Although randomized controlled trials are ongoing, validated data from national clinical registries may advance the reliability of existing knowledge.

Methods: Data on breast cancer surgery performed under general anesthesia between 2013 and 2019 from The Swedish PeriOperative Register and The National Quality Register for Breast Cancer were record-linked. Read More

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"I Beat Cancer to Feel Sick:" Qualitative Experiences of Sleep Disturbance in Black Breast Cancer Survivors and Recommendations for Culturally Targeted Sleep Interventions.

Ann Behav Med 2022 Jun 27. Epub 2022 Jun 27.

Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA.

Background: Sleep disturbance is common and distressing among cancer survivors. Black breast cancer survivors (BBCS) suffer disproportionately from sleep disturbance, yet there is limited research on how to address this issue.

Purpose: This study aimed to understand the multifaceted experiences of sleep disturbance among BBCS and how to culturally target a mobile health (mHealth) intervention to improve sleep outcomes in BBCS. Read More

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A 2-bp deletion in intron 1 of is associated with mRNA expression and chicken body weight.

Br Poult Sci 2022 Jun 27. Epub 2022 Jun 27.

Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

1. Searching for molecular markers related to growth and carcass traits plays a critical role in improvement of the production performance of broilers. Previous studies found that transmembrane protein 182 (TMEM182) inhibits skeletal muscle development, growth, and regeneration, implying that the gene plays an important role during the development process of skeletal muscle. Read More

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MY11 exerts antitumor effects through activation of the NF-κB/PUMA signaling pathway in breast cancer.

Invest New Drugs 2022 Jun 27. Epub 2022 Jun 27.

Institute of Chinese Traditional Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Breast cancer is the most common malignancy in women worldwide, and the discovery of new effective breast cancer therapies with lower toxicity is still needed. We screened a series of chalcone derivatives and found that MY11 ((E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-piperazinylphenyl) prop-2-en-1-one) had the strongest anti-breast cancer activity. MY11 inhibited the growth of MDA-MB-231 and MCF-7 breast cancer cells by arresting the cell cycle and promoting apoptosis, through regulation of the cell cycle and apoptosis-related proteins. Read More

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Effectiveness of logotherapy and nutrition counseling on psychological status, quality of life, and dietary intake among breast cancer survivors with depressive disorder: a randomized clinical trial.

Support Care Cancer 2022 Jun 27. Epub 2022 Jun 27.

Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Breast cancer (BC) can negatively influence multiple facets of survivors' lives including mental health, quality of life (QoL), and dietary behavior. Logotherapy as a psycho-education program may help breast cancer survivors (BCSs) discover their meaning of life throughout distressful events. The present study aimed to determine the effects of logotherapy along with nutrition counseling on psychological status, QoL, and dietary intake among BCSs who were diagnosed with depression. Read More

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Survival outcome assessment for triple-negative breast cancer: a nomogram analysis based on integrated clinicopathological, sonographic, and mammographic characteristics.

Eur Radiol 2022 Jun 27. Epub 2022 Jun 27.

Department of Medical Ultrasound, Fudan University Shanghai Cancer Center, No 270, Dong'an Road, Xuhui District, Shanghai, 200032, China.

Objective: This study aimed to incorporate clinicopathological, sonographic, and mammographic characteristics to construct and validate a nomogram model for predicting disease-free survival (DFS) in patients with triple-negative breast cancer (TNBC).

Methods: Patients diagnosed with TNBC at our institution between 2011 and 2015 were retrospectively evaluated. A nomogram model was generated based on clinicopathological, sonographic, and mammographic variables that were associated with 1-, 3-, and 5-year DFS determined by multivariate logistic regression analysis in the training set. Read More

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Angiogenic activities of interleukin-8, vascular endothelial growth factor and matrix metalloproteinase-9 in breast cancer.

Egypt J Immunol 2022 Jul;29(3):54-63

Department of Immunology and Allergy, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Angiogenesis is a major contributor to tumor growth and metastasis within breast cancer tumor microenvironment in which different proangiogenic factors have been identified and associated with tumor progression, metastasis and poor prognosis. The aim of the current study was to evaluate the angiogenesis among breast cancer patients through ex vivo assessment of the angiogenic factors interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF)-A expressions in excised tumor tissues as well as matrix metalloproteinase 9 (MMP-9) serum levels as well as the prognostic value of MMP-9. Our study included 28 invasive ductal carcinoma female patients who were scheduled for modified radical mastectomy at Medical Research Institute, Alexandria University, Egypt and 10 control subjects. Read More

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Small-Molecule Gankyrin Inhibition as a Therapeutic Strategy for Breast and Lung Cancer.

J Med Chem 2022 Jun 27. Epub 2022 Jun 27.

Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John's University, Queens, New York 11439, United States.

Gankyrin is an oncoprotein responsible for the development of numerous cancer types. It regulates the expression levels of multiple tumor suppressor proteins (TSPs) in liver cancer; however, gankyrin's regulation of these TSPs in breast and lung cancers has not been thoroughly investigated. Additionally, no small-molecule gankyrin inhibitor has been developed which demonstrates potent anti-proliferative activity against gankyrin overexpressing breast and lung cancers. Read More

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Semi-deconvolution of bulk and single-cell RNA-seq data with application to metastatic progression in breast cancer.

Bioinformatics 2022 Jun;38(Supplement_1):i386-i394

Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA 15213, USA.

Motivation: Identifying cell types and their abundances and how these evolve during tumor progression is critical to understanding the mechanisms of metastasis and identifying predictors of metastatic potential that can guide the development of new diagnostics or therapeutics. Single-cell RNA sequencing (scRNA-seq) has been especially promising in resolving heterogeneity of expression programs at the single-cell level, but is not always feasible, e.g. Read More

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