471,113 results match your criteria Breast Reconstruction Refinements and Finishing Touches


Is there a correlation between the severity of Idiopathic Granulomatous Mastitis and pre-treatment Shear-Wave Elastography Findings? Original research.

Ann Ital Chir 2018 ;89:489-494

Aim: The aim of this study was to analyze the correlation between the severity of idiopathic Garulomatous Mastitis (IGM) and the pre-treatment Shear-Wave Elastography (SWE) findings.

Material And Methods: A total of 39 patients diagnosed with granulomatous mastitis were included in the study between the dates of December 2014 and February 2017. The patients were divided into two groups. Read More

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January 2018

Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21.

iScience 2019 Jan 5;12:27-40. Epub 2019 Jan 5.

Max Planck Institute for Molecular Genetics, Otto Warburg Laboratory, Ihnestr. 63-73, 14195 Berlin, Germany. Electronic address:

The DNA damage response (DDR) protects cells against genomic instability. Surprisingly, little is known about the differences in DDR across tissues, which may affect cancer evolutionary trajectories and chemotherapy response. Using mathematical modeling and quantitative experiments, we found that the DDR is regulated differently in human breast and lung primary cells. Read More

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http://dx.doi.org/10.1016/j.isci.2019.01.001DOI Listing
January 2019

Women's stories of living with breast cancer: A systematic review and meta-synthesis of qualitative evidence.

Soc Sci Med 2019 Jan 14;222:231-245. Epub 2019 Jan 14.

Department of Psychology, Faculty of Arts and Social Sciences, Stellenbosch University, Stellenbosch, South Africa. Electronic address:

Rationale: Globally, breast cancer is by far the most frequently occurring cancer amongst women. Whilst the physical consequences of the disease and associated treatments are well documented, a comprehensive picture of how breast cancer is experienced at all stages of disease progression is lacking.

Objective: This systematic review aimed to synthesize qualitative studies documenting women's breast cancer narratives into an empirically based explanatory framework. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.01.020DOI Listing
January 2019

Syndiotactic Peptides for Targeted Delivery.

Acta Biomater 2019 Jan 18. Epub 2019 Jan 18.

Molecular Informatics and Design Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address:

Lack of cell-type specificity and proteolytic susceptibility have long been the major bottlenecks for the development of peptide-based biomaterials for targeted drug delivery. Though a poly-L backbone provides the adaptability to re-conform the peptide structure to bind to a receptor, it also makes the peptide more susceptible to proteolytic cleavage. We have attempted to address this issue by designing a set of syndiotactic peptides de novo, with alternating L- and D-amino acids in succession. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.01.036DOI Listing
January 2019

The effect of metformin on biomarkers and survivals for breast cancer- a systematic review and meta-analysis of randomized clinical trials.

Pharmacol Res 2019 Jan 18. Epub 2019 Jan 18.

Department of Statistics and Management, School of Management, Wuhan Institute of Technology, Wuhan, 430071, China.

Observational studies show a beneficial effect of adjuvant metformin therapy on breast cancer survivals, but data from randomized clinical trials are lacking. This study systematically evaluated the evidence from randomized clinical trials currently available. Ten studies were retrieved, comprising 1520 breast cancer patients. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.036DOI Listing
January 2019

ALK phosphorylates SMAD4 on tyrosine to disable TGF-β tumour suppressor functions.

Nat Cell Biol 2019 Jan 21. Epub 2019 Jan 21.

MOE Key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China.

Loss of TGF-β tumour suppressive response is a hallmark of human cancers. As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and pancreatic cancer. However, such genetic alterations are rare in most cancer types and the underlying mechanism for TGF-β resistance is not understood. Read More

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http://dx.doi.org/10.1038/s41556-018-0264-3DOI Listing
January 2019

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

Nat Cell Biol 2019 Jan 21. Epub 2019 Jan 21.

Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

The presence of disseminated tumour cells (DTCs) in bone marrow is predictive of poor metastasis-free survival of patients with breast cancer with localized disease. DTCs persist in distant tissues despite systemic administration of adjuvant chemotherapy. Many assume that this is because the majority of DTCs are quiescent. Read More

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http://dx.doi.org/10.1038/s41556-018-0267-0DOI Listing
January 2019

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy.

Nat Nanotechnol 2019 Jan 21. Epub 2019 Jan 21.

Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.

Cyclic dinucleotide (CDN) agonists of stimulator of interferon genes (STING) are a promising class of immunotherapeutics that activate innate immunity to increase tumour immunogenicity. However, the efficacy of CDNs is limited by drug delivery barriers, including poor cellular targeting, rapid clearance and inefficient transport to the cytosol where STING is localized. Here, we describe STING-activating nanoparticles (STING-NPs)-rationally designed polymersomes for enhanced cytosolic delivery of the endogenous CDN ligand for STING, 2'3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). Read More

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http://dx.doi.org/10.1038/s41565-018-0342-5DOI Listing
January 2019

Mixed lineage kinase 3 promotes breast tumorigenesis via phosphorylation and activation of p21-activated kinase 1.

Oncogene 2019 Jan 21. Epub 2019 Jan 21.

Department of Surgery, Division of Surgical Oncology, University of Illinois at Chicago, Chicago, IL, 60612, USA.

Mixed lineage kinase 3 (MLK3), a MAP3K member has been envisioned as a viable drug target in cancer, yet its detailed function and signaling is not fully elucidated. We identified that MLK3 tightly associates with an oncogene, PAK1. Mammalian PAK1 being a Ste20 (MAP4K) member, we tested whether it is an upstream regulator of MLK3. Read More

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http://dx.doi.org/10.1038/s41388-019-0690-0DOI Listing
January 2019

Author Correction: Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.

Nat Commun 2019 Jan 21;10(1):419. Epub 2019 Jan 21.

Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK.

The original version of this Article contained an error in the spelling of a member of the PRACTICAL Consortium, Manuela Gago-Dominguez, which was incorrectly given as Manuela Gago Dominguez. This has now been corrected in both the PDF and HTML versions of the Article. Furthermore, in the original HTML version of this Article, the order of authors within the author list was incorrect. Read More

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http://dx.doi.org/10.1038/s41467-018-08106-9DOI Listing
January 2019

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.

Nucl Med Commun 2019 Jan 18. Epub 2019 Jan 18.

Nuclear Medicine Department, Lady Davis Institute, Jewish General Hospital.

Background: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients.

Patients And Methods: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3.5±2. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000981DOI Listing
January 2019

Docosahexaenoic Acid in Mature Breast Milk of Low-Income Mothers.

J Pediatr Gastroenterol Nutr 2019 Jan 16. Epub 2019 Jan 16.

IDIP - Instituto de Desarrollo e Investigaciones Pediátricas "Prof. Dr. Fernando E. Viteri", Hospital de Niños "Sor María Ludovica" de La Plata, Ministerio de Salud/Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, La Plata, Argentina.

Docosahexaenoic acid (DHA) is among the main components of synaptosomal membranes and myelin sheaths. Since DHA is essential for child neurodevelopment, breast milk DHA levels should be improved by optimizing maternal nutrition. We determined DHA percentage levels in breast milk of low-income mothers receiving care at the public healthcare sector. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002284DOI Listing
January 2019

Association between demographic features and perceived social support in the mental adjustment to breast cancer.

Psychooncology 2019 Jan 21. Epub 2019 Jan 21.

Executive Director Research Studies and Additional Projects, Department of Research Studies & Additional projects, Cancer Patients Aid Association, Mumbai, Maharashtra.

Objective: The mental adjustment to a breast cancer diagnosis is traumatic and stressful, with wide-ranging differences in the responses observed in Indian women. We investigated the association between demographic features and perceived social support during the adjustment of patients to breast cancer.

Methods: A total of 393 patients with breast cancer were included in the study. Read More

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http://dx.doi.org/10.1002/pon.5001DOI Listing
January 2019

Quality of life, fatigue and changes therein as predictors of return to work during breast cancer treatment.

Scand J Caring Sci 2019 Jan 21. Epub 2019 Jan 21.

University Paul Valéry Montpellier 3, University Montpellier, EPSYLON EA 4556, Montpellier, France.

Purpose: To our knowledge, only one study has assessed Quality of Life (QOL) as a predictor of return to work (RTW) during breast cancer treatment and one has evaluated multidimensional cancer-related fatigue (CRF) as a determinant of RTW. However, no study has assessed the impact of changes in these variables on RTW. The objective of this study was to evaluate QOL, multidimensional CRF and changes in these variables as determinants of RTW during breast cancer treatment. Read More

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http://dx.doi.org/10.1111/scs.12646DOI Listing
January 2019

Accessory muscles of the anterior thoracic wall and axilla. Cadaveric, surgical and radiological incidence and clinical significance during breast and axillary surgery.

Folia Morphol (Warsz) 2019 Jan 21. Epub 2019 Jan 21.

Department of Anatomy, Medical School, National and Kapodistrian University of Athens, M.Asias 75 street, 11527 ATHENS, Greece.

Background: The present study aims to summarize the accessory muscles of the anterior thoracic wall and axilla that can be encountered during breast and axillary surgery and record their incidence and clinical significance. Moreover, the laterality of the atypical muscles is highlighted and possible gender dimorphism is referred. Accessory anterior thoracic wall muscles include: Langer's axillary arch, sternalis muscle, chondrocoracoideus muscle, chondroepitrochlearis, chondrofascialis, pectoralis minimus, pectoralis quartus and pectoralis intermedius. Read More

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http://dx.doi.org/10.5603/FM.a2019.0005DOI Listing
January 2019

Expression of flTF and asTF splice variants in various cell strains and tissues.

Mol Med Rep 2019 Jan 10. Epub 2019 Jan 10.

Division of Clinical Chemistry and Pharmacology, Department of Laboratory Medicine, Lund University Hospital, S‑221 85 Lund, Sweden.

Tissue factor (TF) expressed at the protein level includes two isoforms: The membrane‑bound full‑length TF (flTF) and the soluble alternatively spliced TF (asTF). flTF is the major thrombogenic form of TF, whereas asTF is more closely associated with tumor growth, angiogenesis, metastasis and cell growth. In order to further investigate the different expression and functions of TF splice variants, the expression of these two splice variants were detected in numerous cell strains and tissues in the present study. Read More

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http://dx.doi.org/10.3892/mmr.2019.9843DOI Listing
January 2019

Arsenic‑induced BRCA1 CpG promoter methylation is associated with the downregulation of ERα and resistance to tamoxifen in MCF7 breast cancer cells and mouse mammary tumor xenografts.

Int J Oncol 2019 Jan 15. Epub 2019 Jan 15.

The University of Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA.

A significant percentage (~30%) of estrogen receptor‑α (ERα)‑positive tumors become refractory to endocrine therapies; however, the mechanisms responsible for this resistance remain largely unknown. Chronic exposure to arsenic through foods and contaminated water has been linked to an increased incidence of several tumors and long‑term health complications. Preclinical and population studies have indicated that arsenic exposure may interfere with endocrine regulation and increase the risk of breast tumorigenesis. Read More

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http://dx.doi.org/10.3892/ijo.2019.4687DOI Listing
January 2019

miR‑671‑3p is downregulated in non‑small cell lung cancer and inhibits cancer progression by directly targeting CCND2.

Mol Med Rep 2019 Jan 15. Epub 2019 Jan 15.

Department of Gastrointestinal Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang 300270, P.R. China.

MicroRNAs (miRNAs) are implicated in the development and progression of non‑small cell lung cancer (NSCLC). A previous study suggested that miR‑671‑3p suppresses the development of breast cancer. However, the role of miR‑671‑3p in NSCLC remains largely unknown. Read More

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http://dx.doi.org/10.3892/mmr.2019.9858DOI Listing
January 2019

Predicting resistance to endocrine therapy in breast cancer: It's time for epigenetic biomarkers (Review).

Oncol Rep 2019 Jan 11. Epub 2019 Jan 11.

Cancer Biology and Epigenetics Group, IPO Porto Research Center (CI‑IPOP), Portuguese Oncology Institute of Porto (IPOPorto) 4200‑072 Porto, Portugal.

Notwithstanding the marked progress in breast cancer (BC) management, it still constitutes the most common malignancy in women and a major cause of morbidity and mortality, thus remaining a major health issue worldwide. Most BC cases are hormone receptor (HR) positive (luminal A or B molecular subtypes) and endocrine treatment (ET) is an important therapeutic modality at all disease stages. Nevertheless, despite substantial improvements in BC patient outcome, effectiveness of ET is limited, as up to 40% of patients eventually relapse or progress and endocrine resistant BC has a less favorable prognosis and constitutes a therapeutic challenge. Read More

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http://dx.doi.org/10.3892/or.2019.6967DOI Listing
January 2019

Shikonin induces an anti‑tumor effect on murine mammary cancer via p38‑dependent apoptosis.

Oncol Rep 2019 Jan 11. Epub 2019 Jan 11.

Department of Japanese Oriental Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930‑0194, Japan.

Breast cancer is the most common malignancy in women. Apoptosis is important for tumor suppression and may delay cancer progression. It was found that shikonin induced apoptosis in 4T1 murine mammary cancer cells and MDA‑MB‑231 human breast cancer cells in vitro. Read More

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http://dx.doi.org/10.3892/or.2019.6966DOI Listing
January 2019

Estradiol induces cell proliferation in MCF‑7 mammospheres through HER2/COX‑2.

Mol Med Rep 2019 Jan 18. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Sanmin, Kaohsiung 807, Taiwan R.O.C.

Cluster of differentiation (CD)44+/CD24- breast cancer cells have stem cell‑like characteristics and are potent initiators of tumorigenesis. Mammosphere cells can partially initiate breast tumorigenesis by inducing estradiol (E2)‑dependent breast cancer cells. However, the mechanisms by which E2 mediates cancer formation in MCF‑7 mammosphere (MS) cells have remained elusive. Read More

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http://dx.doi.org/10.3892/mmr.2019.9879DOI Listing
January 2019

Associations Between Magnetic Resonance Imaging Findings and Clincopathologic Factors in Triple-Negative Breast Cancer.

J Comput Assist Tomogr 2019 Jan 17. Epub 2019 Jan 17.

College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Objective: The aim of the study was to evaluate the magnetic resonance imaging findings associated with clinicopathologic factors in patients with triple-negative breast cancer.

Methods: One hundred one patients with surgically confirmed triple-negative breast cancer who underwent preoperative breast magnetic resonance imaging with diffusion-weighted imaging (DWI) were included in this study. Presence of rim enhancement on contrast-enhanced T1-weighted imaging and hyperintense rim on DWI were visually assessed. Read More

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http://dx.doi.org/10.1097/RCT.0000000000000835DOI Listing
January 2019

Predictors of Work-Related Disability During Early Phases of Breast Cancer Treatment.

Am J Phys Med Rehabil 2019 Jan 17. Epub 2019 Jan 17.

University of Pittsburgh, School of Nursing.

Objective: This study examined the magnitude of work-related disability in post-menopausal women with breast cancer compared to healthy controls. It also examined demographic and clinical correlates of work-related disability in post-menopausal women with breast cancer.

Study Design: Exploratory secondary analysis of longitudinal study. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001138DOI Listing
January 2019

miR-151-5p Modulates APH1a Expression to Participate in Contextual Fear Memory Formation.

RNA Biol 2019 Jan 21. Epub 2019 Jan 21.

c Department of Breast Surgery , Qilu hospital, Shandong University , Jinan , Shandong 250012 , People's Republic of China.

Long-term memory formation requires gene expression and new protein synthesis. MicroRNAs (miRNAs), a family of small non-coding RNAs that inhibit target gene mRNA expression, are involved in new memory formation. In this study, elevated miR-151-5p (miR-151) levels were found to be responsible for hippocampal contextual fear memory formation. Read More

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http://dx.doi.org/10.1080/15476286.2019.1572435DOI Listing
January 2019

Development and validation of Multiplex Liquid Bead Array (MLBA) assay for the simultaneous expression of fourteen genes in Circulating Tumor Cells (CTCs).

Anal Chem 2019 Jan 21. Epub 2019 Jan 21.

Liquid biopsy, based on the molecular information extracted from circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA), offers the possibility to characterize the evolution of a solid tumor in real time and is highly important for diagnostic and therapeutic purposes. The aim of the present study was the development and validation of a novel liquid bead array methodology for the molecular characterization of CTCs and its application in breast cancer. In the present study we developed and evaluated a multiplex PCR-coupled liquid bead array (MLBA) assay for studying simultaneously the expression of fourteen genes in CTCs. Read More

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http://dx.doi.org/10.1021/acs.analchem.8b04975DOI Listing
January 2019

Evaluation of National Comprehensive Cancer Network guideline-based Tool for Risk Assessment for breast and ovarian Cancer (N-TRAC): A patient-reported survey for genetic high-risk assessment for breast and ovarian cancers in women.

J Genet Couns 2019 Jan 21. Epub 2019 Jan 21.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

Identification of mutations that increase lifetime risk of breast and ovarian cancer is critical to improving women's health. Because these mutations are relatively rare in the general population, there is a need for efficient methods to identify appropriate women to undergo genetic testing. The objective of this study was to assess the feasibility, accuracy, and performance of the NCCN guideline-based Tool for Risk Assessment for breast and ovarian Cancer (N-TRAC)-a patient-facing assessment for those affected and unaffected by cancer. Read More

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http://dx.doi.org/10.1002/jgc4.1051DOI Listing
January 2019

The Pecs Anesthetic Blockade: Correlation between Imaging and Histology: A correlation between Magnetic Resonance Imaging, Ultrasound Imaging, Reconstructed Cross-Sectional Anatomy and Cross-Sectional Histology.

Clin Anat 2019 Jan 21. Epub 2019 Jan 21.

Department of Functional Anatomy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Introduction: The interfascial thoracic wall blockades Pecs I and Pecs II are increasingly applied in breast and axillary surgery. Despite the clear anatomical demarcations depicted at their introduction, the clinical outcome is more variable than would be expected based upon the described anatomy. In order to elucidate factors that explain this variability, we evaluated the spread of each injection - medial Pecs I, lateral Pecs I, the deep injection of the Pecs II - separately. Read More

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http://dx.doi.org/10.1002/ca.23333DOI Listing
January 2019

Ferrocene-appended pharmacophores: an exciting approach for modulating the biological potential of organic scaffolds.

Dalton Trans 2019 Jan 21. Epub 2019 Jan 21.

Department of Chemistry, Guru Nanak Dev University, Amritsar-143005, Punjab, India.

Two exemplary contributions of organometallics in medicinal chemistry, ferroquine and ferrocifen, which exhibit excellent anti-plasmodial and anti-cancer activities, respectively, have opened a new field called medicinal organometallic chemistry. This field has been gaining significant interest due to the recent upsurge in ferrocene-linked organic frameworks with promising biological potential. The success of ferrocene is due to the sustained efforts by organic medicinal chemists and its inherent stability in air, heat and light, low toxicity, low cost and reversible redox properties. Read More

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http://dx.doi.org/10.1039/c8dt03440kDOI Listing
January 2019

Myxoid Myofibroblastoma of the Breast With Atypical Cells.

Int J Surg Pathol 2019 Jan 20:1066896918824406. Epub 2019 Jan 20.

1 University of Florida, Gainesville, FL, USA.

The differential diagnosis of myxoid lesions in the breast is broad and includes both benign and malignant entities. Assessment is particularly challenging on core biopsy specimens. Myofibroblastoma, initially thought to be more common in the adult male breast, is being recognized with increasing frequency in the female breast. Read More

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http://dx.doi.org/10.1177/1066896918824406DOI Listing
January 2019

Solid lipid nanoparticles of Annona muricata fruit extract: Formulation, optimization and in vitro Cytotoxicity studies.

Drug Dev Ind Pharm 2019 Jan 19:1-33. Epub 2019 Jan 19.

b Department of Pharmaceutics , Sree Vidyanikethan College of Pharmacy , Tirupati , Andhra Pradesh , India.

The present study was aimed to develop Annona muricata fruit extract loaded solid lipid nanoparticles (SLNs) and explore its cytotoxic potential in vitro model of breast cancers. Extract loaded SLNs was successfully prepared by high-pressure homogenization followed by ultrasonication method and optimized using 2 full factorial design. The extract loaded SLNs were characterized using different parameters such as particle size (PS), % entrapment efficiency (EE), zeta potential (ZP) and % cumulative drug release (CDR). Read More

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http://dx.doi.org/10.1080/03639045.2019.1569027DOI Listing
January 2019

Fluorescent labelling in living dental pulp stem cells by graphene oxide quantum dots.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):115-122

a Department of Cariology and Endodontics, Nanjing Stomatological Hospital , Medical School of Nanjing University , Nanjing , People's Republic of China.

Cellular labelling is possible to offer significant information after transplantation for the purpose of determining stem cell therapy's efficacy. According to the research, it has been reported that graphene oxide quantum dots (GOQDs) are a kind of healthy biological labelling agent for stem cells which show little cytotoxicity. GOQDs' interactions have been examined on the dental pulp stem cells (hDPSCs) of human beings for the purpose of investigating GOQD's biocompatibility and uptake and explored GOQDs' effects on hDPSCs' metabolic activity and the proliferation. Read More

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http://dx.doi.org/10.1080/21691401.2018.1544141DOI Listing
December 2019

Biotin-functionalized copolymeric PEG-PCL micelles for in vivo tumour-targeted delivery of artemisinin.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):104-114

b Zanjan Pharmaceutical Biotechnology Research Center , Zanjan University of Medical Sciences , Zanjan , Iran.

Artemisinin is used as an antimalarial and anticancer agent with minimal toxic effects on the host body. Biotin-PEG-PCL polymers have been used for targeted drug delivery to cancer, as well as to improve the pharmacokinetics of the drug and reduce its effects. In this study, biotin-conjugated copolymers were fabricated with polymerization of the ring opening method and the properties of copolymer and nanoparticles were investigated using various techniques. Read More

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http://dx.doi.org/10.1080/21691401.2018.1543199DOI Listing
December 2019

Riboflavin immobilized FeO magnetic nanoparticles carried with n-butylidenephthalide as targeting-based anticancer agents.

Artif Cells Nanomed Biotechnol 2019 Dec;47(1):210-220

a Department of Applied Chemistry , National Chiao Tung University , Hsinchu , Taiwan.

n-Butylidenephthalide (BP) is a potential anti-cancer drug, which can be extracted from Angelica sinensis (Danggui). Previous reports have shown the effectiveness of BP in treating cancer diseases. However, BP has no targeting capacity towards specific cancer cells. Read More

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http://dx.doi.org/10.1080/21691401.2018.1548473DOI Listing
December 2019

Phyla nodiflora L. Extracts Induce Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7.

Nutr Cancer 2019 Jan 19:1-8. Epub 2019 Jan 19.

a Biotechnology Research Institute, Universiti Malaysia Sabah , Kota Kinabalu , Sabah , Malaysia.

Phyla nodiflora L. has been used as medicinal remedies for various ailments due to its antioxidant, anti-inflammatory, anti-bacterial, anti-tumor activity. Previously, we found that the plant extracts induced DNA fragmentation in MCF-7. Read More

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http://dx.doi.org/10.1080/01635581.2018.1559942DOI Listing
January 2019

Multi-gene assays: effect on chemotherapy use, toxicity and cost in estrogen receptor-positive early stage breast cancer.

J Comp Eff Res 2019 Jan 21. Epub 2019 Jan 21.

Fred Hutchinson Cancer Center & The University of Washington, Seattle, WA 98109, USA.

Aim: To assess multi-gene assay (MGA) effects on chemotherapy use, toxicities, recurrences, and costs in estrogen receptor-positive early breast cancer.

Methods: Meta-analysis performed using data from public databases. Results: Studies included 12,202 women. Read More

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http://dx.doi.org/10.2217/cer-2018-0137DOI Listing
January 2019

Green sample preparations for the bioanalysis of drugs of abuse in complex matrices.

Bioanalysis 2019 Jan 21. Epub 2019 Jan 21.

Department of Clinical & Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, Av. Professor Lineu Prestes, 580, 13B, São Paulo, SP 05508-000, Brazil.

The sample preparation is the most critical step involved in the bioanalytical process. When dealing with green analytical chemistry, sample preparation can be even more challenging. To fit the green analytical chemistry principles, efforts should be made toward the elimination or reduction of the use of toxic reagents and solvents, minimization of energy consumption and increased operator safety. Read More

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http://dx.doi.org/10.4155/bio-2018-0208DOI Listing
January 2019

Sustainable and cost-effective teenage breast awareness campaigns: Insights from a Nigerian high school intervention study.

J Eval Clin Pract 2019 Jan 20. Epub 2019 Jan 20.

Lecturer and Consultant Community Physician, Department of Community Medicine, Chukwuemeka Odumegwu Ojukwu University/University Teaching Hospital, Awka, Nigeria.

Background: With limited government-sponsored breast screening programmes in developing countries, breast awareness remains the only realistic survival hope for millions. Poor levels of knowledge and preventive practices remain in these countries, and early enlightenment to empower teenage high school girls has been advocated for, recently. This study evaluates ways to ensure sustainability for such an approach. Read More

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http://dx.doi.org/10.1111/jep.13101DOI Listing
January 2019

Intracellular localization of an osmocenyl-tamoxifen derivative in breast cancer cells revealed by synchrotron radiation X-ray fluorescence nanoimaging.

Angew Chem Int Ed Engl 2019 Jan 20. Epub 2019 Jan 20.

INSERM, EA 7442, Rayonnement Synchrotron et Recherche Medicale, Grenoble Alpes University, ESRF-The European Synchroton, 71, Avenue des Martyrs, CS40220, 38043 cedex 9, Grenoble, FRANCE.

We have recently developed a series of tamoxifen-like metallocifens of the group-8 metals (Fe, Ru and Os) with strong antiproliferative activity on the triple negative breast cancer cells (MDA-MB-231). This property, not observed for the organic analog 4-hydroxytamoxifen, has been associated with the unique redox behavior of metallocenic moieties, readily affording reactive quinone methides in cancer cells. To shed light on the mechanism of action of these molecules, synchrotron radiation X-ray fluorescence (SR-XRF) nanoimaging studies were performed on cells exposed to osmocenyl-tamoxifen (Oc-OH-Tam) to disclose its intracellular distribution using osmium as an intrinsic reporter. Read More

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http://dx.doi.org/10.1002/anie.201812336DOI Listing
January 2019

Pharmacologic Characterization of Fluzoparib, a Novel Poly(ADP-ribose) polymerase (PARP) Inhibitor Undergoing Clinical Trials.

Cancer Sci 2019 Jan 21. Epub 2019 Jan 21.

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Poly(ADP-ribose) polymerase (PARP) enzymes play an important role in repairing DNA damage and maintaining genomic stability. Olaparib, the first-in-class PARP inhibitor, has shown remarkable clinical benefits in the treatment of BRCA-mutated ovarian or breast cancer. However, the undesirable hematological toxicity and pharmacokinetic properties of olaparib limit its clinical application. Read More

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http://dx.doi.org/10.1111/cas.13947DOI Listing
January 2019

Drugs in lactation.

J Obstet Gynaecol Res 2019 Jan 20. Epub 2019 Jan 20.

Division of Clinical Pharmacology and Toxicology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.

Although most medications can be taken safely during breastfeeding, potential risks of infant toxicity do exist because all medications will be excreted into the breast milk to some extent. The amount of medication excreted in the milk depends mainly on (i) within-drug variation, such as dosing; (ii) between-drug variation including chemical characteristics of the medication; and (iii) host factors, such as maternal pharmacokinetics (PK), including variations of pregnancy-associated changes and their post-partum recovery. Neonatal drug exposure is usually assessed by calculating an expected total infant daily dose through breast milk and comparing it to the normal therapeutic dose. Read More

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http://dx.doi.org/10.1111/jog.13899DOI Listing
January 2019

Changes in dietary intake, plasma carotenoids and erythrocyte membrane fatty acids in breast cancer survivors after a lifestyle intervention: results from a single-arm trial.

J Hum Nutr Diet 2019 Jan 21. Epub 2019 Jan 21.

Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.

Background: The influence of nutrition on breast cancer prognosis is still inconclusive and therefore dietary interventions incorporating dietary biomarkers are needed to confirm compliance with dietary goals and clarify biological mechanisms. The present study assessed whether a lifestyle intervention in breast cancer survivors could affect dietary biomarkers of fruit and vegetables and fatty acids.

Methods: In this phase II single-arm trial, 37 overweight/obese early stage breast cancer patients completed a 12-week diet and exercise intervention. Read More

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http://dx.doi.org/10.1111/jhn.12621DOI Listing
January 2019

Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors.

J Dermatol 2019 Jan 21. Epub 2019 Jan 21.

Institute for Hematopathology, Hamburg, Germany.

The histogenesis of extraocular sebaceous carcinomas is - in contrast to ocular sebaceous carcinomas - unclear, and information about the exact cellular architecture of these lesions and even of the normal sebaceous gland is still scarce. This study attempts to elucidate the histogenesis of sebaceous tumors, using multicolor immunofluorescence stainings to analyze 21 cases of sebaceous tumors (six each of extraocular sebaceous carcinoma, sebaceous adenoma and sebaceoma, and three cases of steatocystomas) and eight cases of normal sebaceous glands for p63, several keratins, androgen receptor, adipophilin, epithelial membrane antigen (EMA) and Ki-67. The data of this observational study provide evidence for the existence of two subpopulations of progenitors in normal sebaceous glands: (i) p63 K5 progenitors which generate the K10 luminal cells of sebaceous ducts; and (ii) p63 K5 K7 progenitors which finally generate K7 adipophilin EMA sebocytes. Read More

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http://dx.doi.org/10.1111/1346-8138.14765DOI Listing
January 2019

Bridging the Data Gap in Breast Cancer Risk Assessment to Enable Widespread Clinical Implementation across the Multiethnic Landscape of the US.

J Cancer Treatment Diagn 2018 3;2(4):1-6. Epub 2018 Aug 3.

Genetic Technologies, Ltd, Fitzroy, VIC 3065, Australia.

Breast cancer remains the second leading cause of cancer death among women and is the most commonly diagnosed cancer in women. Breast cancer risk assessment has been clinically available for nearly 30 years yet is under-utilized in practice for multiple reasons. Incorporation of polygenic risk as well as breast density measurements, promise to increase the accuracy of risk assessment. Read More

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http://dx.doi.org/10.29245/2578-2967/2018/4.1137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334765PMC

Imaging of fiber-like structures in digital breast tomosynthesis.

J Med Imaging (Bellingham) 2019 Jul 11;6(3):031404. Epub 2019 Jan 11.

University of Chicago, Department of Radiology, Chicago, Illinois, United States.

Fiber-like features are an important aspect of breast imaging. Vessels and ducts are present in all breast images, and spiculations radiating from a mass can indicate malignancy. Accordingly, fiber objects are one of the three types of signals used in the American College of Radiology digital mammography (ACR-DM) accreditation phantom. Read More

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http://dx.doi.org/10.1117/1.JMI.6.3.031404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328371PMC

A combination of the PI3K pathway inhibitor plus cell cycle pathway inhibitor to combat endocrine resistance in hormone receptor-positive breast cancer: a genomic algorithm-based treatment approach.

Am J Cancer Res 2018 1;8(12):2359-2376. Epub 2018 Dec 1.

Department of Molecular and Experimental Medicine, Avera Cancer Institute Sioux Falls, SD, USA.

Cyclin-dependent kinase 4 (CDK4) and CDK6 together with D-type cyclins (D1, D2 and D3) to promote cell cycle entry and progression through G1 by inactivating retinoblastoma protein (RB) by inhibiting an INK4 family of CDK inhibitors (CDKN2A/B). Selective cyclin-dependent kinase inhibitors are game changers in the clinical management of hormone receptor-positive/HER2-negative advanced breast cancers. There are currently three CDK4/6 inhibitors that have been approved by the US Food and Drug administration: palbociclib, ribociclib, and abemaciclib. Read More

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December 2018

Integration of Cancer Registry Data into the Text Information Extraction System: Leveraging the Structured Data Import Tool.

J Pathol Inform 2018 24;9:47. Epub 2018 Dec 24.

Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Introduction/background: Cancer registries in the US collect timely and systematic data on new cancer cases, extent of disease, staging, biomarker status, treatment, survival, and mortality of cancer cases. Existing methodologies for accessing local cancer registry data for research are time-consuming and often rely on the manual merging of data by staff registrars. In addition, existing registries do not provide direct access to these data nor do they routinely provide linkage to discrete electronic health record (EHR) data, reports, or imaging data. Read More

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http://dx.doi.org/10.4103/jpi.jpi_38_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319041PMC
December 2018

Behavioural thermoregulation via microhabitat selection of winter sleeping areas in an endangered primate: implications for habitat conservation.

R Soc Open Sci 2018 Dec 5;5(12):181113. Epub 2018 Dec 5.

Moroccan Primate Conservation Foundation, Azrou, Morocco.

Strategic microhabitat selection allows animals in seasonally cold environments to reduce homeostatic energy costs, particularly overnight when thermoregulatory demands are greatest. Suitable sleeping areas may therefore represent important resources for winter survival. Knowledge of microhabitat use and potential impacts of anthropogenic habitat modification can aid species conservation through development of targeted habitat management plans. Read More

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http://dx.doi.org/10.1098/rsos.181113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304142PMC
December 2018

RNA binding motif protein 3 (RBM3) drives radioresistance in nasopharyngeal carcinoma by reducing apoptosis via the PI3K/AKT/Bcl-2 signaling pathway.

Am J Transl Res 2018 15;10(12):4130-4140. Epub 2018 Dec 15.

Department of Radiation Oncology, Xijing Hospital, The Fourth Military Medical University No. 127 West Changle Road, Xi'an 710032, China.

Radioresistance is an important obstacle to nasopharyngeal carcinoma (NPC) therapy. In this study, we explored the role of RNA-binding motif protein 3 (RBM3) in the radioresistance of NPC and its underlying mechanism. We measured the expression of RBM3 in 20 clinical NPC tissues and in NPC cell lines. Read More

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December 2018

Microfluidic droplets content classification and analysis through convolutional neural networks in a liquid biopsy workflow.

Am J Transl Res 2018 15;10(12):4004-4016. Epub 2018 Dec 15.

Department of Mathematics, Computer Science and Physics, University of Udine Italy.

In a recent paper we presented an innovative method of liquid biopsy, for the detection of circulating tumor cells (CTC) in the peripheral blood. Using microfluidics, CTC are individually encapsulated in water-in-oil droplets and selected by their increased rate of extracellular acidification (ECAR). During the analysis, empty or debris-containing droplets are discarded manually by screening images of positive droplets, increasing the operator-dependency and time-consumption of the assay. Read More

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December 2018