3,693 results match your criteria Breast Journal[Journal]


Multigene testing in breast cancer: What have we learned from the 21-gene recurrence score assay?

Breast J 2020 May 26. Epub 2020 May 26.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Most invasive breast cancers express hormone receptors (HR) and typically have a favorable prognosis following endocrine therapy. Patients at a higher risk of recurrence can be identified by multigene prognostic classifiers such as the 21-gene recurrence score (RS) assay, 70-gene prognostic signature, PAM-50, 12-gene molecular score, and others. The 21-gene RS assay (Oncotype Dx™, Genomic Health, Redwood City, CA) has level I clinical evidence and is the most widely used multigene assay in North America. Read More

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http://dx.doi.org/10.1111/tbj.13859DOI Listing

Complication rates among women undergoing preventive mastectomy: An Austrian registry.

Breast J 2020 May 25. Epub 2020 May 25.

Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.

Germline variations in the BRCA-1 and BRCA-2 genes are associated with an increased risk of breast cancer. These variants are found in 5% of all breast cancer cases. Prophylactic mastectomy is the most effective risk-reducing method and shows high rates of patient satisfaction and acceptance. Read More

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http://dx.doi.org/10.1111/tbj.13877DOI Listing

Breast amyloid presenting as calcifications.

Breast J 2020 May 25. Epub 2020 May 25.

Department of Pathology, MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1111/tbj.13841DOI Listing

COVID-19: Impact and challenges at breast imaging unit.

Breast J 2020 May 25. Epub 2020 May 25.

Department of Radiology, KFHU, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

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http://dx.doi.org/10.1111/tbj.13891DOI Listing

The application of intraoperative specimen mammography for margin status assessment in breast-conserving surgery: A single-center retrospective study.

Breast J 2020 May 24. Epub 2020 May 24.

Department of Breast Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

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http://dx.doi.org/10.1111/tbj.13835DOI Listing

Comparison of intraoperative ultrasound-guided excision and hookwire-guided excision of impalpable breast lesions: An economic evaluation.

Breast J 2020 May 24. Epub 2020 May 24.

Department of Surgery, University of Qld, Princess Alexandra Hospital, Brisbane, Qld, Australia.

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http://dx.doi.org/10.1111/tbj.13883DOI Listing

Impact of neoadjuvant and adjuvant chemotherapy on invasive lobular carcinoma: A propensity score-matched analysis of SEER data.

Breast J 2020 May 25. Epub 2020 May 25.

Department of Surgery, Keio University School of Medicine, Tokyo, Japan.

Invasive lobular carcinoma (ILC) has a different treatment response from invasive ductal carcinoma (IDC). We assessed whether perioperative chemotherapy was associated with improved prognosis in patients with ILC. Retrospective data of women who underwent surgery for ILC were extracted from the SEER database. Read More

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http://dx.doi.org/10.1111/tbj.13884DOI Listing

Is it ductal carcinoma in situ with microinvasion or "Ductogenesis"? The role of myoepithelial cell markers.

Authors:
Shahla Masood

Breast J 2020 May 23. Epub 2020 May 23.

Department of Pathology, University of Florida College of Medicine - Jax, Jacksonville, FL, USA.

Mammary myoepithelial cells have been under-recognized for many years since they were considered less important in breast cancer tumorigenesis compared to luminal epithelial cells. However, in recent years with advances in genomics, cell biology, and research in breast cancer microenvironment, more emphasis has been placed on better understanding of the role that myoepithelial cells play in breast cancer progression. As the result, it has been recognized that the presence or absence of myoepithelial cells play a critical role in the assessment of tumor invasion in diagnostic breast pathology. Read More

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http://dx.doi.org/10.1111/tbj.13897DOI Listing

Primary primitive neuroectodermal tumor of the breast: Analysis of clinical outcomes of twenty-one patients.

Breast J 2020 May 23. Epub 2020 May 23.

Department of Clinical Oncology, Kasr Alainy School of Medicine, Cairo University, Cairo, Egypt.

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http://dx.doi.org/10.1111/tbj.13894DOI Listing

Breast implant-associated anaplastic large cell lymphoma and the obligation of insurance providers.

Breast J 2020 May 20. Epub 2020 May 20.

Division of Surgical Oncology, Mayo Clinic, Phoenix, AZ, USA.

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http://dx.doi.org/10.1111/tbj.13893DOI Listing

Breast cancer surgery under the shadow of COVID-19: Quest for optimal axillary management after neo-adjuvant chemotherapy.

Breast J 2020 May 20. Epub 2020 May 20.

Department of Surgery, The School of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.

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http://dx.doi.org/10.1111/tbj.13892DOI Listing

Congenital breast deformities: Anatomical basis and surgical approaches for optimal aesthetic outcomes.

Breast J 2020 May 19. Epub 2020 May 19.

Department of Plastic Surgery, Cleveland Clinic, Cleveland, Ohio.

Plastic surgeons routinely encounter patients desiring correction of breast asymmetry, hypoplastic growth, or other aesthetic concerns. An appropriate recognition of congenital breast conditions is critical for plastic surgeons. Without consideration of underlying anatomical abnormalities in these patients, surgical intervention may not result in optimal aesthetic outcomes. Read More

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http://dx.doi.org/10.1111/tbj.13798DOI Listing

An unusual site of scorpion bite.

Breast J 2020 May 18. Epub 2020 May 18.

Department of Obstetrics and Gynecology, Military Training Hospital Mohammed V, Rabat, Morocco.

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http://dx.doi.org/10.1111/tbj.13879DOI Listing

Paraneoplastic dermatomyositis in hereditary breast and ovarian cancer syndrome.

Authors:
Navin Kumar Svs Deo

Breast J 2020 May 18. Epub 2020 May 18.

Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1111/tbj.13888DOI Listing

Invasive breast carcinoma with osteoclast-like giant cells (OLGC): A rare entity causing diagnostic confusion.

Breast J 2020 May 18. Epub 2020 May 18.

Northern Beaches Hospital, Frenchs Forest, NSW, Australia.

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http://dx.doi.org/10.1111/tbj.13890DOI Listing

A review of mucinous lesions of the breast.

Breast J 2020 May 18. Epub 2020 May 18.

Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY, USA.

Mucinous lesions of the breast include a variety of benign and malignant epithelial processes that display intracytoplasmic or extracellular mucin, including mucocele-like lesions, mucinous carcinoma, solid papillary carcinoma, and other rare subtypes of mucin-producing carcinoma. The finding of free-floating or stromal mucin accumulations is a diagnostic challenge of which the significance depends on the clinical, radiologic, and pathologic context. This article emphasizes the differential diagnosis between benign and malignant mucin-producing lesions, with a brief consideration of potential mimics, such as biphasic and mesenchymal lesions with associated with mucinous, myxoid, or matrix material. Read More

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http://dx.doi.org/10.1111/tbj.13878DOI Listing

Periductal stroma sarcoma of the breast.

Breast J 2020 May 18. Epub 2020 May 18.

Department of Surgery, UCLA, Los Angeles, California, USA.

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http://dx.doi.org/10.1111/tbj.13886DOI Listing
May 2020
1.433 Impact Factor

Delayed docetaxel extravasation in case of breast cancer.

Breast J 2020 May 18. Epub 2020 May 18.

Department of medical oncology, Habib Bourguiba Hospital, Sfax, Tunisia.

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http://dx.doi.org/10.1111/tbj.13882DOI Listing

Autologous mastectomy reconstruction: Communication among the breast surgery team to maximize aesthetic and oncologic outcome.

Breast J 2020 May 16. Epub 2020 May 16.

Brian P. Dickinson, M.D., Inc., Newport Beach, California, USA.

Mastectomy breast reconstruction with autologous tissue is challenging. Oncologic and aesthetic goals face previous surgical scars, radiation, chemotherapy, or other comorbidities. We describe a simple approach for autologous mastectomy reconstruction so that breast and plastic and reconstructive surgeons can maximize aesthetic outcomes and minimize wound complications. Read More

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http://dx.doi.org/10.1111/tbj.13874DOI Listing

Effects of breast cancer treatment on metabolic health.

Breast J 2020 May 16. Epub 2020 May 16.

Faculty of Health Sciences, Universidad San Jorge, Zaragoza, Spain.

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http://dx.doi.org/10.1111/tbj.13852DOI Listing

HER2 testing across practices-Have we come to a consensus on the ideal method of testing? A systematic literature review.

Breast J 2020 May 12. Epub 2020 May 12.

Department of Pathology and Laboratory Medicine, Mills-Peninsula Hospital, Burlingame, California, USA.

Human epidermal growth factor (HER2) is an oncogene that codes for HER2 protein. The gene is amplified, and protein is overexpressed in 20% of patients and carries a poor prognosis. HER2-positive tumors tend to be more aggressive and highly proliferative. Read More

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http://dx.doi.org/10.1111/tbj.13867DOI Listing

Duct carcinoma in situ: A personal perspective.

Authors:
Michael D Lagios

Breast J 2020 May 10. Epub 2020 May 10.

The Breast Cancer Consultation Service, Tiburon, CA, USA.

In the recent past, DCIS was a rare diagnosis established by biopsy of palpable breast masses or nipple changes. Mammography increased the frequency of a DCIS diagnosis by 20 × resulting in a tsunami of small circa 10 mm lesions detected only by mammography. The impact of pathologic technique in examining and characterizing such lesions is reviewed, and the development of algorithms incorporating prognostic factors and histology based on serial sequential processing techniques are described and contrasted with those which relied on tissue sampling. Read More

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http://dx.doi.org/10.1111/tbj.13860DOI Listing

How image-guided core needle biopsies altered the treatment of breast disease: Challenges accepted and opportunities taken.

Authors:
Susan C Lester

Breast J 2020 May 9. Epub 2020 May 9.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

The technique of combining stereotactic targeting of breast lesions with an automated spring-loaded needle biopsy gun reported in 1990 by Steve Parker and colleagues not only ushered in the era of diagnosis almost exclusively by image guided core needle biopsy, but also profoundly changed the practice of pathologists, radiologists, surgeons, and medical oncologists and had major effects on the treatment of women with breast cancer. In this special issue of The Breast Journal celebrating 25 years of publication, it is of value to reflect back on these changes, some expected and some unanticipated, which have occurred over the past three decades and to consider the reasons why core needle biopsies should be considered a milestone in breast pathology. Read More

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http://dx.doi.org/10.1111/tbj.13862DOI Listing

Considerations for performing immediate breast reconstruction during the COVID-19 pandemic.

Breast J 2020 May 7. Epub 2020 May 7.

Unità di Chirurgia Plastica, Dipartimento Scienza della Salute della Donna e del Bambino, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy.

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http://dx.doi.org/10.1111/tbj.13876DOI Listing

The power of one: Evaluating the impact of a single multi-disciplinary treatment visit on time to treatment.

Breast J 2020 May 7. Epub 2020 May 7.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Breast cancer treatment often requires multi-disciplinary evaluation, which can require multiple visits, delaying time to treatment initiation (TTI). The present analysis evaluated the impact of system-wide initiatives to reduce TTI by evaluating TTI for patients completing treatment evaluation in a single visit compared with those having multiple visits. The results demonstrated that patients who completed multi-disciplinary evaluation in a single visit had a reduced median TTI (27 vs 32 days, P = . Read More

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http://dx.doi.org/10.1111/tbj.13875DOI Listing

Iatrogenic issues in breast pathology.

Breast J 2020 May 7. Epub 2020 May 7.

Department of Pathology and Laboratory Medicine, The Perelman School of Medicine and Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Modern breast imaging techniques include digital mammography, 3-dimensional tomography, high-resolution ultrasound, and magnetic resonance imaging. Each of these has enabled the diagnosis of ever smaller, largely non-palpable lesions, not all of which require surgery. As these techniques evolved, so too did methods of accurately targeting and sampling the lesions, necessitating methods to mark the areas should surgical localization be needed. Read More

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http://dx.doi.org/10.1111/tbj.13868DOI Listing

Neuroendocrine neoplasms of the breast: A review focused on the updated World Health Organization (WHO) 5th Edition morphologic classification.

Breast J 2020 May 7. Epub 2020 May 7.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Neuroendocrine breast neoplasms are uncommon invasive carcinomas that have historically been poorly defined due to various definitions of what constitutes a neuroendocrine carcinoma. The 5th Edition of the World Health Organization (WHO) Classification of Breast Tumors has moved to a dichotomous classification of neuroendocrine neoplasms in the breast in order to become standardized with classifications of other organ systems. Neuroendocrine breast neoplasms in the new edition are classified as "neuroendocrine tumor" and "neuroendocrine carcinoma. Read More

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http://dx.doi.org/10.1111/tbj.13863DOI Listing

A systematic review of the economic evaluations of trastuzumab in metastatic breast cancer.

Breast J 2020 May 7. Epub 2020 May 7.

Department of Life and Health Sciences, School of Sciences and Engineering, Pharmacy School, Pharmacoepidemiology-Pharmacovigilance, University of Nicosia, Nicosia, Cyprus.

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http://dx.doi.org/10.1111/tbj.13853DOI Listing

Breast pathology: The core of an integrated practice of personalized breast care.

Authors:
Shahla Masood

Breast J 2020 May 5. Epub 2020 May 5.

Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Jacksonville, Florida.

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http://dx.doi.org/10.1111/tbj.13873DOI Listing

Margin assessment before intraoperative radiotherapy during breast conserving surgery-Does the addition of MarginProbe decrease the need for addition of fractionated whole breast radiation?

Breast J 2020 May 4. Epub 2020 May 4.

Surgical Ward B, Meir Medical Center, Kfar Saba, Israel.

When performing Breast Conserving Surgery (BCS) with Intraoperative Radiation Therapy (IORT), positive resection margin necessitates not only re-lumpectomy-but also the addition of fractionated whole breast radiation. This retrospective study of 106 patients undergoing BCS and IORT aims to evaluate intraoperative margin assessment use in our center, and the contribution of the MarginProbe device (MP) to achieving negative surgical margins. Eleven out of 106 lumpectomy specimens had a total of 17 margins positive for tumor cells. Read More

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http://dx.doi.org/10.1111/tbj.13865DOI Listing

Genotype-phenotype associations in breast pathology: Achievements of the past quarter century.

Breast J 2020 May 4. Epub 2020 May 4.

Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

The first genotype-phenotype relationship in breast pathology developed in 1994 with the discovery of the CDH1 gene. This finding eventually provided biological insight into the characteristic morphology of invasive lobular carcinoma. Subsequent investigative efforts have uncovered additional molecular alterations largely responsible for the histology of several breast neoplasms including secretory carcinoma, adenoid cystic carcinoma, tall cell carcinoma with reversed polarity, fibroepithelial lesions, and most recently, adenomyoepithelioma. Read More

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http://dx.doi.org/10.1111/tbj.13861DOI Listing

Use of preoperative prophylactic antibiotics following breast localization procedures: Do they reduce surgical site infections?

Breast J 2020 Apr 28. Epub 2020 Apr 28.

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1111/tbj.13854DOI Listing

Review of the current state of digital image analysis in breast pathology.

Breast J 2020 Apr 27. Epub 2020 Apr 27.

Sinai Health System, Toronto, ON, Canada.

Advances in digital image analysis have the potential to transform the practice of breast pathology. In the near future, a move to a digital workflow offers improvements in efficiency. Coupled with artificial intelligence (AI), digital pathology can assist pathologist interpretation, automate time-consuming tasks, and discover novel morphologic patterns. Read More

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http://dx.doi.org/10.1111/tbj.13858DOI Listing

Impact of socioeconomic status on psychological functioning in survivorship following breast cancer and reconstruction.

Breast J 2020 Apr 26. Epub 2020 Apr 26.

Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Socioeconomic status (SES) remains an important population health risk factor and impacts a patient's experience of care during breast cancer. This study explored the relationship between SES and quality of life and satisfaction in survivorship following breast cancer and reconstruction. All patients underwent breast reconstruction at a single academic center from 2013 to 2017. Read More

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http://dx.doi.org/10.1111/tbj.13849DOI Listing

Primary tumor resection in de novo stage IV breast cancer patients.

Breast J 2020 Apr 26. Epub 2020 Apr 26.

University of Kansas Medical Center - General Surgery, Kansas City, KS, USA.

Breast and axillary surgery in Stage IV disease is outside current national guidelines but has been a topic of ongoing debate. A single institution retrospective study identified women with de novo stage IV BC from 2011-2016 to evaluate the rate and goals of primary site surgery. Only 10. Read More

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http://dx.doi.org/10.1111/tbj.13850DOI Listing

Breast incidental findings on abdominal and chest MRI.

Breast J 2020 Apr 24. Epub 2020 Apr 24.

Department of Radiology, University of Kansas Medical and Cancer Centers, Kansas City, KS, USA.

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http://dx.doi.org/10.1111/tbj.13826DOI Listing

Siliconoma mimicking a locally invasive fungating breast malignancy.

Breast J 2020 Apr 20. Epub 2020 Apr 20.

Department of Internal Medicine, Hartford Hospital, Hartford, Connecticut.

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http://dx.doi.org/10.1111/tbj.13833DOI Listing

Classic IgG4-related sclerosing mastitis is not so classic.

Breast J 2020 Apr 20. Epub 2020 Apr 20.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

IgG4-related sclerosing mastitis (IgG4-RM) is a rare, benign, mass-forming fibroinflammatory disease of the breast that can mimic a neoplastic process and pose a diagnostic challenge to clinicians and pathologists. We present a case of IgG4-RM in an 84-year-old woman and highlight the characteristic morphologic findings that should allow the pathologist to raise the possibility of this entity. We also briefly discuss pathophysiology and differential diagnosis. Read More

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http://dx.doi.org/10.1111/tbj.13846DOI Listing

First experience with a novel "wireless" wire localization device.

Breast J 2020 Apr 18. Epub 2020 Apr 18.

Breast Imaging Division, Department of Radiology, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1111/tbj.13847DOI Listing

Management of a periductal stromal tumor in a young woman: Our breast unit experience.

Breast J 2020 Apr 16. Epub 2020 Apr 16.

Breast Unit, Breast Imaging Department of Radiology, University Hospital of Parma, Parma, Italy.

Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. PDST is distinguished from phyllodes tumor by its lack of leaf-like architecture; however, it is still unclear whether PDST is a separate entity or a certain spectrum of phyllodes tumor. Read More

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http://dx.doi.org/10.1111/tbj.13843DOI Listing

Acute toxicities after proton beam therapy following breast-conserving surgery for breast cancer: Multi-institutional prospective PCG registry analysis.

Breast J 2020 Apr 15. Epub 2020 Apr 15.

Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona.

We investigated adverse events (AEs) and clinical outcomes for proton beam therapy (PBT) after breast-conserving surgery (BCS) for breast cancer. From 2012 to 2016, 82 patients received PBT in the prospective multi-institutional Proton Collaborative Group registry. AEs were recorded prospectively at each institution. Read More

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http://dx.doi.org/10.1111/tbj.13812DOI Listing