3,348 results match your criteria Breast Fibroadenoma

Evaluation of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume, and neutrophil/monocyte ratio in patients with benign breast lesions.

A Varman S Alkan

Bratisl Lek Listy 2021 ;122(7):489-492

Objectives: In this study, we aimed to demonstrate the relationship between he neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte rate (NMR) and mean platelet volume (MPV) in patients with BIRADS grades of benign breast lesions.

Background: In many recent studies, NLR, PLR, NMR and MPV change significantly in connection with chronic inflammation and are suggested for use as prognostic markers in some diseases. However, the relationship between the cancer probability of benign breast diseases and mentioned hematological parameters has not been investigated in any previous study. Read More

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January 2021

Use of Lateral Oncoplasty for Multiquadrant Giant Fibroadenoma: A Novel Approach.

Cureus 2021 May 18;13(5):e15090. Epub 2021 May 18.

Surgical Oncology, Medica Cancer Hospital, Rangapani, IND.

Giant fibroadenomas are uncommon benign lesions, defined as fibroadenomas of >5 cm in size and/or weighing more than 500 g. They can distort the shape of the breast and cause asymmetry, so they should be excised. Here, we report two cases of giant fibroadenoma, where wide local excision and reconstruction with lateral oncoplasty were done. Read More

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Pathological and Immunohistochemical Microscopy of Natural Cases of Canine and Feline Neoplastic Mammary Lesions.

Microsc Microanal 2021 Jun 15:1-13. Epub 2021 Jun 15.

Pathology Department, Faculty of Veterinary Medicine, Alexandria University, Edfina22758, Egypt.

Mammary cancer is the second most common tumor worldwide. Small animal mammary neoplasms provide an outstanding model to study cancer in humans, as tumors in both share a similar environment, histopathologic features, and biological behavior. This study aims to investigate the percentage and microscopy of breast tumors in affected dogs and cats; its relationship to breed, age, and sex; and the immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR), Ki-67, and cytokeratin 8. Read More

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Breast pathology in adolescence.

Breast Dis 2021 Jun 2. Epub 2021 Jun 2.

Serviço de Ginecologia, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Objective: Description of breast pathology in adolescents.

Methods: A retrospective descriptive study of adolescents who were referred to the Gynecology consultation of a tertiary pediatric hospital for suspected breast pathology, in the period from the 1st June 2011 to the 30th December 2018.

Results: One hundred and two female adolescents (11 to 18 years old) with suspected breast pathology were referred (6% of the motives for consultation), with confirmation in 58 (56. Read More

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Low diffusion level within a fibroadenoma as the sole sign of ductal carcinoma in situ: A case report.

Breast Dis 2021 Jun 1. Epub 2021 Jun 1.

Department of Radiological Sciences, Azienda Ospedaliero Universitaria Ospedali Riuniti, Università Politecnica delle Marche, Ancona, Italy.

We present a case of ductal carcinoma in situ within a fibroadenoma. Breast cancer arising within fibroadenoma incidence ranges from 0.125% to 0. Read More

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High expression of FBP1 and LDHB in fibroadenomas and invasive breast cancers.

Breast Dis 2021 Jun 1. Epub 2021 Jun 1.

Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: The role of gluconeogenesis in cancer cells as the reverse pathway for glycolysis is not well known. Several studies of gluconeogenesis in cancer cells still show conflicting results. Expression of key enzymes such as FBP1 and LDHB in cancer tissues may explain the role of gluconeogenesis in tumor development. Read More

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Primary squamous cell carcinoma of the breast in a young female- A rare ailment.

Clin Case Rep 2021 May 24;9(5):e04214. Epub 2021 May 24.

Department of Surgery Nepal Cancer Hospital and Research Center Lalitpur Nepal.

Primary squamous cell carcinoma of the breast is an extremely rare invasive breast carcinoma with rapid progression and worse prognosis. Careful assessment and diagnosis of the entity should also be considered in a rapidly progressing breast tumor. Read More

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The Influence of rs1859168 Polymorphism on Serum Expression of HOTTIP and Its Target miR-615-3p in Egyptian Patients with Breast Cancer.

Biomolecules 2021 May 14;11(5). Epub 2021 May 14.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Fayoum 63511, Egypt.

Background: Polymorphisms of long noncoding RNAs are lately documented as hazardous factors for the development of numerous tumors. Furthermore, the evaluation of noncoding RNAs has emerged as a novel detector of breast cancer patients. We aimed to genotype the HOXA transcript at the distal tip (HOTTIP) rs1859168 and assess its relationship with the levels of the serum HOTTIP and its target miR-615-3p in patients with breast cancer (BC). Read More

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Unveiling the histopathologic spectrum of MRI-guided breast biopsies: an institutional pathological-radiological correlation.

Breast Cancer Res Treat 2021 Jun 27;187(3):673-680. Epub 2021 May 27.

Department of Pathology, Medical College of Wisconsin, 9200 W. Wisconsin Ave., Lab Building, Lower Level, Room L69, Milwaukee, WI, 53226, USA.

Purpose: Breast magnetic resonance imaging (MRI) has high sensitivity but suffers from low specificity, resulting in many benign breast biopsies for MRI-detected lesions. We sought to compare histologic findings between patients who underwent MRI-guided breast biopsy versus biopsy via other imaging modalities as well as to examine features associated with malignancy in the MRI cohort to help inform MRI-biopsy practice.

Methods: A 2-year (2018-2019) retrospective review of breast biopsies at our enterprise was conducted. Read More

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Giant breast fibroadenoma in pregnancy.

Ceska Gynekol 2021 ;86(2):114-117

Objective: To present unusual case of rapidly growing breast fibroadenoma during pregnancy.

Case Report: Breast fibroadenomas are hormone-dependent tumors which can grow rapidly during pregnancy. We present a case of giant fibroadenoma, first detected before pregnancy, which grew rapidly under the influence of pregnancy hormones and was excised in the third trimester. Read More

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Breast Disorders in Adolescence: A Review of the Literature.

Breast Care (Basel) 2021 Apr 30;16(2):149-155. Epub 2020 Nov 30.

2nd Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece.

Background: Adolescence is accompanied by a variety of changes in young breast development, which greatly affects the adolescent's psychology and socialization.

Summary: PubMed, EMBASE, and the Cochrane Library were searched for studies relative to epidemiology, clinical characteristics, diagnosis, and management of all breast disorders in adolescence and their consequences. Development disorders are breast asymmetry, breast atrophy, breast hypoplasia, hypomastia, juvenile breast hypertrophy, and tuberous breast. Read More

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A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review.

Onco Targets Ther 2021 6;14:3003-3011. Epub 2021 May 6.

Department of Pathology, Shihezi University School of Medicine and the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang, 832002, People's Republic of China.

Phyllodes tumors (PTs) account for less than 1% of breast tumors, and malignant PTs account for even less. Here, we described an unusual case of malignant PT with mixed liposarcoma (myxoid liposarcoma [MLP] and pleomorphic liposarcoma [PLP]). A 52-year-old woman discovered a small lump in her left breast. Read More

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Primary breast angiosarcoma resembling a common benign tumor: A case report.

Ann Med Surg (Lond) 2021 May 10;65:102281. Epub 2021 Apr 10.

Department of Surgery, Al-Mouwassat University Hospital, Damascus University, Faculty of Medicine, Damascus, Syria.

Introduction And Importance: The breast angiosarcoma is a rare malignant vascular neoplasm; it represents nearly 0.05% of all breast cancers. Clinically, it could look like a haemangioma or pseudoangiomatous hyperplasia. Read More

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Hybrid Spectral-IRDx: Near-IR and Ultrasound Attenuation System for Differentiating Breast Cancer from Adjacent Normal Tissue.

IEEE Trans Biomed Eng 2021 May 4;PP. Epub 2021 May 4.

Objective: While performing surgical excision for breast cancer (lumpectomy), it is important to ensure a clear margin of normal tissue around the cancer to achieve complete resection. The current standard is histopathology; however, it is time-consuming and labour-intensive requiring skilled personnel.

Method: We describe a Hybrid Spectral-IRDx - a combination of the previously reported Spectral-IRDx tool with multimodal ultrasound and NIR spectroscopy techniques. Read More

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Differential diagnosis between small breast phyllodes tumors and fibroadenomas using artificial intelligence and ultrasound data.

Quant Imaging Med Surg 2021 May;11(5):2052-2061

Department of Ultrasound, Peking University People's Hospital, Beijing, China.

Background: It is challenging to differentiate between phyllodes tumors (PTs) and fibroadenomas (FAs). Artificial intelligence (AI) can provide quantitative information regarding the morphology and textural features of lesions. This study attempted to use AI to evaluate the ultrasonic images of PTs and FAs and to explore the diagnostic performance of AI features in the differential diagnosis of PTs and FAs. Read More

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Emergency embolization for breast pseudoaneurysm following vacuum-assisted biopsy: a case report.

Pan Afr Med J 2021 8;38:135. Epub 2021 Feb 8.

Department of Radiology, Ha Noi Medical University Hospital, Ha Noi, Vietnam.

Vacuum-assisted breast biopsy (VABB) is a minimally invasive procedure and has become an important treatment method. Although VABB is a minimally invasive procedure, it might cause complications, particularly those associated with blood vessels. In this article, we aimed to describe a 35-year-old female who experienced pseudoaneurysm post-VABB and was successfully treated with embolization. Read More

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Early onset, multiple, bilateral fibroadenomas of the breast: a case report.

BMC Womens Health 2021 04 21;21(1):170. Epub 2021 Apr 21.

Department of Surgery, Division of Surgical Oncology, University of California San Francisco, San Francisco, CA, USA.

Background: While fibroadenomas are common in the general population, affecting 10-20% of women, they are rarely early-onset, multiple, and bilateral.

Case Presentation: An 18-year-old woman presented with a 6 year history of multiple, bilateral breast masses without family history of breast disease. Magnetic resonance imaging (MRI, Fig. Read More

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Clinical practice guideline for breast fibroadenoma: Chinese Society of Breast Surgery (CSBrS) practice guideline 2021.

Chin Med J (Engl) 2021 Apr 15;134(9):1014-1016. Epub 2021 Apr 15.

Department of Breast Center, Peking University People's Hospital, Beijing 100044, China.

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Management of Pediatric Breast Masses: A Multi-institutional Retrospective Cohort Study.

J Surg Res 2021 Aug 10;264:309-315. Epub 2021 Apr 10.

Center for Surgical Outcomes Research, Nationwide Children's Hospital, Columbus, Ohio; Department of Surgery, Division of Pediatric Surgery, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio.

Background: The objective of our study was to describe the workup, management, and outcomes of pediatric patients with breast masses undergoing operative intervention.

Materials And Methods: A retrospective cohort study was conducted of girls 10-21 y of age who underwent surgery for a breast mass across 11 children's hospitals from 2011 to 2016. Demographic and clinical characteristics were summarized. Read More

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Surgery for fibroadenoma arising from axillary accessory breast.

Sung Ryul Lee

BMC Womens Health 2021 04 7;21(1):139. Epub 2021 Apr 7.

Department of Surgery, Damsoyu Hospital, 234 Hakdong-ro, Gangnam-gu, Seoul, Republic of Korea.

Background: Patients with fibroadenomas in axillary accessory breasts (AABs) have a palpable mass, cyclic axillary pain, and aesthetic concerns that must be addressed. We compared the baseline patient characteristics, AAB characteristics, and surgical outcomes of patients with AABs with and without fibroadenomas undergoing surgical excision. We also monitored the patients for recurrence of axillary fibroadenomas. Read More

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Development of a digital breast phantom for photoacoustic computed tomography.

Biomed Opt Express 2021 Mar 10;12(3):1391-1406. Epub 2021 Feb 10.

The Department of Electronic Engineering, Tsinghua University, Beijing, 100084, China.

Photoacoustic (PA) imaging provides morphological and functional information about angiogenesis and thus is potentially suitable for breast cancer diagnosis. However, the development of PA breast imaging has been hindered by inadequate patients and a lack of ground truth images. Here, we report a digital breast phantom with realistic acoustic and optical properties, with which a digital PA-ultrasound imaging pipeline is developed to create a diverse pool of virtual patients with three types of masses: ductal carcinoma in situ, invasive breast cancer, and fibroadenoma. Read More

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Hamartomas of the Breast: A Mimic of Fibroadenoma and Cytological Pitfall.

J Cytol 2020 Oct-Dec;37(4):210-211. Epub 2020 Oct 31.

Department of Cytopathology, PGIMER, ABVIMS, RML Hospital, New Delhi, India.

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October 2020

Retrospective study of malignant phyllodes tumors of the breast: Younger age, prior fibroadenoma surgery, malignant heterologous elements and surgical margins may predict recurrence.

Breast 2021 Jun 17;57:62-70. Epub 2021 Mar 17.

Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. Electronic address:

Purpose: The potential recurrence rate of malignant phyllodes tumors (MPTs) of the breast is high, and the prognostic factors are still unclear. We therefore aim to study the factors affecting the outcome of MPTs.

Methods: A retrospective review of MPT patients treated from 2006 to 2020 at our institution was conducted. Read More

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Sliding window based deep ensemble system for breast cancer classification.

J Med Eng Technol 2021 May 26;45(4):313-323. Epub 2021 Mar 26.

Department of Biomedical Systems and Informatics Engineering, Hijjawi Faculty for Engineering Technology, Yarmouk University, Irbid, Jordan.

Breast cancer is a severe problem for women around the world especially in developing countries, according to recent reports from the World Health Organization (WHO). High accuracy and early detection of breast cancer reduces the mortality rate, in the other hand, recognition of breast cancer is a complicated issue. Various studies and methods have been carried out to overcome this problem and to obtain accurate screening of breast cancer. Read More

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An atypically located pleomorphic adenoma: Radiological and pathological correlation.

J Med Imaging Radiat Oncol 2021 Mar 25. Epub 2021 Mar 25.

Department of Radiology, Royal Perth Hospital, Perth, Western Australia, Australia.

Pleomorphic adenoma is a common benign salivary gland neoplasm which very rarely occurs in the breast. Its radiologic and pathologic appearance may be mistaken for other benign or malignant lesions such as a fibroadenoma or invasive ductal carcinoma. Due to the risk of local recurrence and, rarely, malignant transformation, wide local excision with clear margins is recommended. Read More

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A Study of Anxiety and Depression in Benign Breast Disease.

J Midlife Health 2020 Oct-Dec;11(4):200-209. Epub 2021 Jan 21.

Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background: To compare the prevalence of anxiety and depression levels in patients with benign breast disease (BBD) and healthy individuals using Hospital Anxiety and Depression Scale (HADS) and Brief Patient Health Questionnaire (BPHQ).

Methods: This study includes 100 patients who were clinically suspected of having BBDs and were matched against 100 healthy age-matched controls from June 2016 and July 2018. The diagnosis of BBD was established on the basis of ultrasonography, fine needle aspiration cytology, and/or histopathology. Read More

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January 2021

[The HRT follow-up consultation. What to do in case of breast tumour (clinical or radiological) and microcalcifications. Postmenopausal women management: CNGOF and GEMVi clinical practice guidelines].

Gynecol Obstet Fertil Senol 2021 May 20;49(5):485-492. Epub 2021 Mar 20.

CHRU, Hôpitaux universitaires de Strasbourg, 1, place de l'hôpital, 67091 Strasbourg, France; Unité d'imagerie mammaire, Institut de cancérologie Strasbourg Europe (ICANS), 17, rue Albert-Calmette. 67033 Strasbourg cedex, France.

Objective: The objective was to evaluate the diagnostic value of clinical examination and complementary imaging in the exploration of a breast lump or microcalcifications occurring in a postmenopausal woman taking hormonal replacement therapy (HRT), based on a systematic review of the literature in order to make recommendations for HRT management.

Methods: A literature review was conducted using Medline, Cochrane Library data and international recommendations in French and English until 2020.

Results: In the presence of a clinical breast mass in postmenopausal women, there is no clinical evidence to rule out cancer. Read More

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Giant Juvenile Fibroadenoma of the breast in a 13-year-old Pakistani girl with excellent cosmetic outcome after subareolar enucleation - A case report.

Int J Surg Case Rep 2021 Feb 28;79:450-454. Epub 2021 Jan 28.

Section of Breast Surgery, Department of Surgery, The Aga Khan University, P.O. Box 3500, Stadium Road, Karachi, 74800, Pakistan. Electronic address:

Introduction: Fibroadenoma is the most common benign lesion of breast in young women, characterized by an aberrant proliferation of both epithelial and mesenchymal elements. It is termed giant fibroadenoma when it is larger than 5 cm or weighs more than 500 g with an incidence of 0.5-2% of all fibroadenomas. Read More

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February 2021

Quantitative proteome profiling stratifies fibroepithelial lesions of the breast.

Oncotarget 2021 Mar 2;12(5):507-518. Epub 2021 Mar 2.

Cancer Biology, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Telangana, 500007, India.

Breast fibroepithelial lesions (FELs) include heterogeneous pathological tumors, involving indolent fibroadenoma (FAD) to potentially aggressive phyllodes tumors (PTs). The current grading system remains unreliable in differentiating these tumors due to histological heterogeneity and lack of appropriate markers to monitor the sudden and unpredictable malignant transformation of PTs. Thus, there exists an imminent need for a marker-based diagnostic approach to augment the conventional histological platform that could lead to accurate diagnosis and distinction of FELs. Read More

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Understanding diffusion-weighted MRI analysis: Repeatability and performance of diffusion models in a benign breast lesion cohort.

NMR Biomed 2021 07 18;34(7):e4508. Epub 2021 Mar 18.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.

Diffusion-weighted MRI (DWI) is an important tool for oncology research, with great clinical potential for the classification and monitoring of breast lesions. The utility of parameters derived from DWI, however, is influenced by specific analysis choices. The purpose of this study was to critically evaluate repeatability and curve-fitting performance of common DWI signal representations, for a prospective cohort of patients with benign breast lesions. Read More

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