3,454 results match your criteria Breast Fibroadenoma


Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):552-553

Hangzhou Normal University Affiliated Hospital - Department of Thyroid and Breast Surgery, Hangzhou, Zhejiang, China.

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Data of real-world reference scores for EORTC QLQ-C30 and QLQ-BR23 at baseline in women with early breast cancer and other breast diseases.

Data Brief 2022 Aug 3;43:108347. Epub 2022 Jun 3.

Department of Gynecology with Breast Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Patient-reported outcomes are information about health status and health-related quality of life collected directly from patients. The data in this publication contain the first assessment of patient-reported outcomes (PROs) from real-life measurements in the breast cancer center at Charité - Universitätsmedizin Berlin between November 2016 and March 2021. At baseline (before the start of treatment), 1727 ambulatory patients with early breast cancer, ductal carcinoma (DCIS), fibroadenoma, and other breast diseases were registered in the digital PRO-system as part of clinical routine. Read More

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Lipomatous (Fat-Forming) Solitary Fibrous Tumor of the Breast: A Case Report of an Uncommon Variant of a Rare Clinical Entity.

Case Rep Oncol 2022 Jan-Apr;15(1):455-461. Epub 2022 Apr 28.

Pathology Department, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.

Solitary fibrous tumor (SFT) is an uncommon tumor of mesenchymal origin, which can arise at any anatomic location and can exhibit versatile histological features and a clinical course ranging from benign to frankly malignant. Lipomatous (fat-forming) SFT is a morphological variant of SFT characterized by an adipose tissue component. Breast SFT is an extremely rare clinical entity, and the literature review yielded only 28 previously reported cases. Read More

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Clinical effect of trans-areolar resection and minimally invasive mammotome biopsy in the treatment of breast fibroadenoma and its impact on the quality of life of patients.

Am J Transl Res 2022 15;14(5):3539-3546. Epub 2022 May 15.

Department of Mammary Health Care, Liaocheng Dongchangfu Maternal and Child Health Hospital Liaocheng 252000, Shandong Province, China.

Objective: To explore the effects of trans-areolar resection and minimally invasive mammotome biopsy on therapeutic effect.

Methods: A total of 131 patients with breast fibroadenoma were selected as the research subjects. Among them, 58 patients were treated by trans-areolar resection and included in group A (GA), and 73 patients were treated by minimally invasive mammotome biopsy and included in group B (GB). Read More

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Breast filariasis presenting fibroadenoma like nodules: a rare diagnosis.

J Parasit Dis 2022 Jun 13;46(2):334-336. Epub 2022 Feb 13.

Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna, India.

India has still not eradicated filariasis, which is still endemic throughout the country. This study focuses on the breast as a non-typical but not uncommon site of breast disease characterized by nematodes causing obstruction of lymphatic vessels caused by filariasis. The case described herein involves a 26-year-old married female who presented with a subcutaneous nodule in her left breast. Read More

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Diagnostic difficulties in giant benign phyllodes tumor.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):1035-1044

Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania;

Phyllodes tumors (PTs) are rare tumors of the breast, which encompass both stromal and epithelial components. The maximum incidence is in the fourth decade of life. Most of these tumors are benign, but about one third can be malignant acting as sarcomas. Read More

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Excision of breast fibroepithelial lesions: when is it still necessary?-A 10-year review of a regional centre.

Breast Cancer Res Treat 2022 May 31. Epub 2022 May 31.

Providence Breast Centre, Mount Saint Joseph Hospital, 3080 Prince Edward Street, Vancouver, BC, V5T 3N4, Canada.

Purpose: Fibroepithelial lesions (FEL) range from benign fibroadenoma (FA) to malignant phyllodes tumor (PT), but can be difficult to diagnose on core needle biopsy (CNB). This study assesses risk factors for phyllodes tumor (PT) and recurrence and whether a policy to excise FELs over 3 cm in size is justified.

Methods: Patients having surgery for FELs from 2009 to 2018 were identified. Read More

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Recurrent ovarian cancer presenting with isolated axillary lymph node metastasis: A rare case report.

Ann Med Surg (Lond) 2022 May 20;77:103640. Epub 2022 Apr 20.

Department of Oncology, Hanoi Medical University, Hanoi, Viet Nam.

Introduction: Ovarian cancer with metastatic axillary lymph node is a very rare entity. This study aims to report a case of recurrent ovarian cancer presenting with isolated axillary lymph node metastasis.

Case Presentation: We report a case of a 58-year-old patient with recurrent ovarian cancer in the axillary node and a suspected lesion in the ipsilateral breast. Read More

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Dosimetric analysis of ultrasound-guided high intensity focused ultrasound ablation for breast fibroadenomas: a retrospective study.

Int J Hyperthermia 2022 ;39(1):743-750

College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

Objective: To investigate the factors influencing the sonication dosage and efficiency of ultrasound-guided high intensity focused ultrasound (USgHIFU) for breast fibroadenomas.

Materials And Methods: Forty-nine patients with 78 breast fibroadenomas who underwent USgHIFU were retrospectively analyzed. The energy efficiency factor (EEF) was set as dependent variable, and the factors possibly influencing the sonication dosage, including age, body mass index (BMI), fibroadenoma size, distance from the shallow margin of the fibroadenoma to skin, distance from the deep margin of the fibroadenoma to pectoralis major, types of near field acoustic pathway, and Adler blood flow classification of ultrasound, were set as independent variables. Read More

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Computer-Aided Detection of Quantitative Signatures for Breast Fibroepithelial Tumors Using Label-Free Multi-Photon Imaging.

Molecules 2022 May 23;27(10). Epub 2022 May 23.

Department of Hepato-Biliary-Pancreatic Surgery and Breast Surgery, Ehime University, Ehime 791-0204, Japan.

Fibroadenomas (FAs) and phyllodes tumors (PTs) are major benign breast tumors, pathologically classified as fibroepithelial tumors. Although the clinical management of PTs differs from FAs, distinction by core needle biopsy diagnoses is still challenging. Here, a combined technique of label-free imaging with multi-photon microscopy and artificial intelligence was applied to detect quantitative signatures that differentiate fibroepithelial lesions. Read More

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Preoperational diagnosis and management of breast ductal carcinoma arising within fibroadenoma: Two case reports.

World J Clin Cases 2022 Apr;10(11):3496-3504

Department of Breast Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China.

Background: Ductal carcinoma (DCIS) arising within fibroadenoma is a type of tumor that is rarely encountered in clinic, with only about 100 cases of carcinoma arising within a fibroadenoma reported in the literature. Here, we present two cases of breast DCIS arising within a fibroadenoma and discuss their clinical and imaging findings as well as treatment.

Case Summary: The patients did not have cancer-related personal and family histories. Read More

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Overexpression of lncRNA MAPT-AS1 exacerbates cell proliferation and metastasis in breast cancer.

Transl Cancer Res 2022 Apr;11(4):835-847

Department of Laboratory Science, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, China.

Background: To investigate the function of MAPT antisense RNA 1 (MAPT-AS1) in breast cancer (BC), evaluating its potential diagnostic value for BC patients.

Methods: This study involved 498 patients with BC, 222 patients with benign breast diseases, including 74 cases each of of breast fibroadenoma, breast intraductal papilloma, and ductal hyperplasia and 429 healthy controls. We collected 20 cases of BC tissues and adjacent normal tissues and blood was taken from each participant. Read More

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Fibroepithelial lesions of the breast: A review of recurring diagnostic issues.

Semin Diagn Pathol 2022 Apr 19. Epub 2022 Apr 19.

Department of Anatomical Pathology, Division of Pathology, Singapore General Hospital, Singapore. Electronic address:

Breast fibroepithelial lesions, which are composed of biphasic epithelial and stromal proliferations, comprise the fascinating spectrum of fibroadenomas and phyllodes tumours. Common difficulties surrounding their diagnosis include distinguishing between cellular fibroadenomas and benign phyllodes tumours, grading phyllodes tumours, classifying fibroepithelial lesions in paediatric patients, and handling surgical margins. Recent molecular advances have provided insights into the pathogenesis of fibroepithelial lesions and may offer diagnostic, prognostic, and therapeutic information. Read More

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ALK-positive Large B-Cell Lymphoma Presenting as a Circumscribed Breast Mass with Germinal Center Immunophenotype.

Int J Surg Pathol 2022 May 6:10668969221099627. Epub 2022 May 6.

Department of Pathology, 24575University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.

We report a rare case of ALK-positive large B cell lymphoma which initially presented as a circumscribed breast mass in a young woman mimicking fibroadenoma. The lymphoma demonstrated typical immunoblastic morphology with monomorphic round nuclei and prominent central nucleoli. Immunophenotypically, the lymphoma was positive for MUM1,CD138, BOB1, OCT2, PAX5 (focal), CD4, and was negative for CD20, CD79a and all other T cell antigens. Read More

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Scimitar syndrome - An incidental diagnosis in a case of fibroadenoma.

Radiol Case Rep 2022 Jun 20;17(6):2231-2234. Epub 2022 Apr 20.

Department of Respiratory Medicine, GITAM Institute of Medical Sciences and Research, GITAM (Deemed to be University), Rushikonda, Visakhapatnam, Andhra Pradesh, India.

Scimitar syndrome is a rare congenital anomaly which is characterised by anomalous pulmonary venous drainage of the either entire right lung or part of it into the inferior vena cava or portal vein or hepatic vein or right atrium occasionally. This can be associated with hypoplasia of the right lung, dextroposition, underdevelopment of right pulmonary artery and anomalous systemic arterial supply from the descending aorta to the hypoplastic lung. A 36 year old female came with history of swelling in the right breast which turned up to be right breast fibroadenoma. Read More

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Value of Histogram of Gray-Scale Ultrasound Image in Differential Diagnosis of Small Triple Negative Breast Invasive Ductal Carcinoma and Fibroadenoma.

Cancer Manag Res 2022 21;14:1515-1524. Epub 2022 Apr 21.

Department of Radiology, China-Japan Union Hospital of Jilin University, Changchun, People's Republic of China.

Objective: To investigate the value of gray-scale ultrasound (US) image histogram in the differential diagnosis between small (≤2.00 cm), oval, or round triple negative breast invasive ductal carcinoma (TN-IDC) and fibroadenoma (FA).

Methods: Fifty-five cases of triple negative breast invasive ductal carcinoma (TN-IDC group) and 57 cases of breast fibroadenoma (FA group) confirmed by pathology in Hubei cancer hospital from September 2017 to September 2021 were analyzed retrospectively. Read More

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False-negatives due to poor specimens can be prevented based on the macroscopic findings for breast Vacuum-Assisted Biopsy specimens.

J Med Invest 2022 ;69(1.2):51-64

Tokushima Breastcare Clinic.

Purpose: Ultrasound-guided breast tissue biopsy is an essential technique for diagnosing breast disease, but sample errors reduce its accuracy. This study investigated whether the histopathological results can be inferred from the macroscopic findings for Ultrasound-guided breast Vacuum Assisted Biopsy (VAB) specimens.

Methods: Biopsy specimens from 101 patients who underwent mammary gland VAB were photographed with a smartphone, and the relationships between the macroscopic findings and the pathological results were examined. Read More

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Assessment of Stromal Elastin Fibers in Breast Cancer and Fibroadenomas: Is There a Correlation With Ultrasound Elastography Findings?

Eur J Breast Health 2022 Apr 1;18(2):134-140. Epub 2022 Apr 1.

Department of Radiology, Van Yüzüncü Yıl University Faculty of Medicine, Van, Turkey.

Objective: The stiffness of a breast lesion provides information on the likelihood of malignancy. The most important factor affecting this stiffness is the composition of the extracellular matrix (ECM). The aim of this study was to assess the elastin fiber contents of malignant breast lesions and fibroadenomas and investigate any relationship between the shear wave velocity (SWV) measured by ultrasonography, and the elastin fiber content of lesions. Read More

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Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia Necessitating Mastectomy.

Am Surg 2022 Apr 17:31348221086811. Epub 2022 Apr 17.

12279Wake Forest University, Department of Surgery, Winston-Salem, NC, USA.

Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon, benign breast lesion often diagnosed incidentally and frequently mistaken for fibroadenoma given similar radiographic appearance. Histopathology classically reveals diffuse, dense fibrous stromal background with a complex network of spindle cells forming slit-like spaces, giving it the appearance of angiomatous proliferation. Surgical excision is generally not necessary. Read More

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Cryoablation of breast lesions: our experience.

Radiologia (Engl Ed) 2022 Mar;64 Suppl 1:49-53

Servicio de Radiodiagnóstico, Hospital Lucus Augusti, Lugo, Spain; Grupo de Patología Mamaria Hospital Universitario Lucus Augusti-IDIS, Lugo, Spain.

Cryoablation is a therapeutic technique that uses very low temperatures to destroy cells; transcutaneous cryoablation can be performed under imaging guidance. This simple procedure is done on an outpatient basis with local anesthesia. Cryoablation has proven effective in the treatment of benign breast lesions, such as fibroadenomas. Read More

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Recurrent Acromegaly in a Patient With a Mutation.

AACE Clin Case Rep 2022 Mar-Apr;8(2):85-88. Epub 2021 Nov 20.

Neuroendocrine Unit and Neuroendocrine and Pituitary Tumor Clinical Center, Massachusetts General Hospital, Boston, Massachusetts.

Background/objective: is a cell-cycle checkpoint kinase and is part of the ATM-CHEK2-p53 cascade, which is protective against carcinogenesis. We describe a germline CHEK2 mutation in a patient with acromegaly and other tumors.

Case Report: We present a woman with a germline 110delC mutation previously diagnosed with fibroadenoma of the breast and papillary thyroid carcinoma. Read More

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November 2021

Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study.

Int J Mol Sci 2022 Apr 3;23(7). Epub 2022 Apr 3.

Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Via Pansini 15, 80131 Naples, Italy.

Extracellular vesicles (EVs) shuttle proteins, RNA, DNA, and lipids crucial for cell-to-cell communication. Recent findings have highlighted that EVs, by virtue of their cargo, may also contribute to breast cancer (BC) growth and metastatic dissemination. Indeed, EVs are gaining great interest as non-invasive cancer biomarkers. Read More

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Ductal carcinoma in situ arising from fibroadenoma; a rare case with review of literature.

Ann Med Surg (Lond) 2022 Mar 2;75:103449. Epub 2022 Mar 2.

Smart Health Tower, Madam Mitterrand Street, Sulaimani, Kurdistan, Iraq.

Introduction: ibroadenoma (FA) is a common benign breast mass representing a group of hyperplastic breast lobules due to the deviation of normal development. This study aims to present a rare case of ductal carcinoma in situ (DCIS) associated with fibroadenoma.

Case Report: A 49-year-old married female presents with a right breast mass for five years. Read More

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A Five-Year Review of the Outcomes of Breast Imaging Reporting and Data System 4 Lesions in Hospital Universiti Sains Malaysia.

Cureus 2022 Mar 1;14(3):e22757. Epub 2022 Mar 1.

Department of Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, MYS.

Purpose: The Breast Imaging Reporting and Data System (BI-RADS) lexicon used in reporting breast imaging has several categories with specific positive predictive values for breast cancer. Among those, BI-RADS 4 is associated with a wider range of risk for breast cancer, which makes the decision for biopsy difficult. The study aim was to determine the malignancy rate and clinical outcomes of BI-RADS 4 lesions in Hospital Universiti Sains Malaysia (HUSM) for a period of five years. Read More

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[Breast asymmetry inadolescent girls can be caused by large benign tumours].

Ugeskr Laeger 2022 03;184(12)

Kirurgisk Afdeling, Sydvestjysk Sygehus Esbjerg.

This is a case report of a 14-year-old female with a giant juvenile fibroadenoma in her right breast. She successfully underwent surgical excision with simultaneous breast lift and reconstruction using a modified Goldilocks procedure. We want to address the importance of referring patients with breast asymmetry to surgical assessment and furthermore advocate for considering use of reconstructive techniques or conferring with a plastic surgeon when removing these large tumours in order to achieve a more aesthetically beautiful and symmetric result. Read More

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Complex refractive index of freshly excised human breast tissue as a marker of disease.

Lasers Med Sci 2022 Mar 18. Epub 2022 Mar 18.

Laboratory of Electronic Devices and Materials, Department of Electrical & Electronic Engineering, University of West Attica, Egaleo, 12244, Greece.

We report differences in the refractive index of healthy and tumorous freshly excised human breast tissue as determined from reflectance profile measurements at five wavelengths (432 nm, 532 nm, 633 nm, 964 nm, 1551 nm) in the visible and near-infrared using a standard prism-coupling refractometer. These refractive index differences, particularly in the near-infrared, can be used to distinguish fibroadenomas and cancerous growths not only from normal breast tissue but also from each other. Read More

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Association of Paraoxonase 1 Gene Polymorphisms with the Risk of Breast Fibroadenoma and Breast Cancer in the Females of Guangxi, China.

J Healthc Eng 2022 8;2022:3642799. Epub 2022 Mar 8.

Department of Thyroid Gland and Breast Surgery, Guidong People's Hospital of Guangxi Zhuang Autonomous Region, Wuzhou 543001, Guangxi, China.

Fibroadenoma of the breast is a common cause of a benign breast lump in premenopausal women. The consensus view is that women with fibroadenomas are not at significantly increased risk of developing breast cancer. The objective of this research was to explore the association of PON1 rs662 and rs705382 with the risk of breast fibroadenoma (BF) and breast cancer (BC) in the females of Guangxi in southern China. Read More

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Is there a threshold for red cell distribution width to predict malignancy in breast masses?

Niger J Clin Pract 2022 Mar;25(3):349-353

Department of Surgery, Haseki Training and Research Hospital, Istanbul, Turkey.

Background: Red cell distribution width (RDW) has been shown to have predictive properties in different diseases as well as solid cancers.

Aim: We aimed to investigate the discriminative properties of RDW in benign and malignant breast lesions.

Subjects And Methods: In a retrospective cohort study the files of patients who underwent surgery for fibroadenomas (Group A) and breast cancer with axillary lymph node metastasis (Group B) were reviewed. Read More

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CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability.

Int J Biol Sci 2022 24;18(4):1434-1450. Epub 2022 Jan 24.

Department of Cell Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China.

BRCA1 is frequently down-regulated in breast cancer, the underlying mechanism is unclear. Here we identified DCAF8L1, an X-linked gene product, as a DDB1-Cullin associated Factor (DCAF) for CUL4 E3 ligases to target BRCA1 and BARD1 for proteasomal degradation. Forced expression of DCAF8L1 caused reduction of BRCA1 and BARD1, and impaired DNA damage repair function, conferring increased sensitivity to irradiation and DNA damaging agents, as well as Olaparib, a PARPi anticancer drug; while depletion of DCAF8L1 restored BRCA1 and suppressed the growth of its xenograft tumors. Read More

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