3,119 results match your criteria Breast Fibroadenoma


An Uncommon Pairing of common Tumors: Case Report of Ductal Carcinoma Within Fibroadenoma.

Hawaii J Med Public Health 2019 Feb;78(2):39-43

Department of Surgery, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (AM, SS, NF, SW).

Fibroadenomas are common benign tumors of the female breast. In the appropriate clinical setting, they are often managed expectantly without excision. Rarely, cancer may arise within a fibroadenoma, and this diagnosis mandates prompt treatment for malignancy. Read More

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February 2019

Discrimination of breast cancer from benign tumours using Raman spectroscopy.

PLoS One 2019 14;14(2):e0212376. Epub 2019 Feb 14.

Qatar Biomedical Research Institute, Doha, Qatar.

Breast cancer is the most common cancer among women worldwide, with an estimated 1.7 million cases and 522,000 deaths in 2012. Breast cancer is diagnosed by histopathological examination of breast biopsy material but this is subjective and relies on morphological changes in the tissue. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212376PLOS
February 2019

Twist1 was detected in mesenchymal cells of mammary fibroadenoma and invasive components of breast carcinoma in rats.

J Toxicol Pathol 2019 Jan 1;32(1):19-26. Epub 2018 Sep 1.

Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.

Fibroadenoma (FA) is a common mammary fibroepithelial tumor. The tumor size of the FA is increased by estrogen, progesterone, prolactin, and pregnancy, whereas it decreases after menopause. These observations in humans indicate that FA is hormone dependent. Read More

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http://dx.doi.org/10.1293/tox.2018-0029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361665PMC
January 2019
1 Read

Sonography of Palpable Breast Lumps in a Tertiary Health Care Centre in Nepal.

J Nepal Health Res Counc 2019 Jan 28;16(41):396-400. Epub 2019 Jan 28.

Department of Radiology and Imaging, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Background: With a palpable lesion in the breast, the goal is to diagnose malignancy at the earliest. Ultrasonography is used for evaluating symptomatic patients especially those with dense breasts where mammography gives limited information. The objective of this study was to evaluate the sonographic pattern of the palpable breast lumps and correlate with the final pathological diagnosis. Read More

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January 2019

Recurrent vulvar breast fibroadenoma: presentation of a rare clinical condition.

J Int Med Res 2019 Feb 8:300060519826771. Epub 2019 Feb 8.

1 Department of Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Vulvar fibroadenoma is an ectopic mammary-like fibroepithelial tumor of undetermined pathogenesis. Surgery is usually the primary option of treatment for this condition. Recurrent vulvar fibroadenoma is a rare clinical condition, and it has therapeutic challenges for surgeons and pathologists. Read More

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http://dx.doi.org/10.1177/0300060519826771DOI Listing
February 2019
1 Read

Largest giant juvenile fibroadenoma of the breast.

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

University of the West Indies, St Augustine, Trinidad and Tobago.

Juvenile giant fibroadenoma is a rare benign tumour of the breast accounting for 0.5% of all fibroadenomas. The presentation can be very dramatic and may result in breast deformity and may mimic a rare malignant tumour. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22727
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http://dx.doi.org/10.1136/bcr-2018-227277DOI Listing
January 2019
4 Reads

[A Case of Metachronal Phyllodes Tumors That Presented Bilaterally in the Breast].

Gan To Kagaku Ryoho 2018 Dec;45(13):1854-1856

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.

A 33-year-old woman underwent resection of a right breast mass, which was diagnosed as a fibroadenoma 15 years ago. Ten years later, a right breast mass appeared again, and it was diagnosed as a fibroadenoma based on core needle biopsy. After observation for a while, the mass increased in size, and she underwent resection of the tumor, which was diagnosed as a borderline-malignant phyllodes tumor. Read More

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December 2018
2 Reads

Moesin is an independent prognostic marker for ER-positive breast cancer.

Oncol Lett 2019 Feb 6;17(2):1921-1933. Epub 2018 Dec 6.

Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, P.R. China.

Moesin, a cytoskeletal protein belonging to the ezrin-radixin-moesin family serves important roles in cell motility, invasion and metastasis. Moesin has been demonstrated to be of prognostic significance in tumor progression, due to its role in the metastatic process; however, its role in breast cancer is not well characterized. In the present study, the moesin expression was determined using immunohistochemistry in 404 and 46 patients with breast cancer and fibroadenoma, respectively, and the associations between moesin expression and the clinical parameters and prognostic values were analyzed. Read More

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http://dx.doi.org/10.3892/ol.2018.9799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341613PMC
February 2019

Primary Osteosarcoma of the Breast: Pathophysiology and Imaging Review.

Curr Probl Diagn Radiol 2019 Jan 3. Epub 2019 Jan 3.

Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Extraskeletal osteosarcoma are rare malignant mesenchymal neoplasms of soft tissues representing around 1% of all soft tissue. The exact mechanism of tumorigenesis of primary breast osteosarcoma is still unclear. However, most of the cases develop without a recognized etiologic factor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03630188183021
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http://dx.doi.org/10.1067/j.cpradiol.2019.01.001DOI Listing
January 2019
4 Reads

Pediatric Breast Fibroadenomas: A Systematic Review and Algorithm for Treatment.

Ann Plast Surg 2019 Jan 9. Epub 2019 Jan 9.

Columbia University Vagelos College of Physicians and Surgeons, New York, NY.

Background: Pediatric breast masses cause concern for both the patient and their family, although malignancy represents less than 1% of lesions in this population. No studies have systematically described resection and reconstructive methods for different sizes and locations of pediatric breast fibroadenomas. The aim of this study was to perform a recent systematic review of the literature regarding the surgical resection of pediatric breast fibroadenomas and to propose an algorithm for safe and effective treatment that maximizes both therapeutic and aesthetic goals while acknowledging possible future need for nipple-sparing mastectomy. Read More

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http://Insights.ovid.com/crossref?an=00000637-900000000-9711
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http://dx.doi.org/10.1097/SAP.0000000000001717DOI Listing
January 2019
3 Reads

Serial image changes in ultrasonography after the excision of benign breast lesions by mammotome® biopsy system.

Saudi J Biol Sci 2019 Jan 17;26(1):178-182. Epub 2018 Aug 17.

Department of Thyroid and Breast Surgery, Zibo Central Hospital, Zibo 255020, China.

Mammotome-an ultrasound guided vacuum-assisted breast biopsy (VABB) device, has proved beneficial to the treatment of benign breast lesions. The aim of this study is to analyze the characteristics of ultrasound images of residual cavity and the changes in ultrasound images at follow-up at different intervals after the excision of benign breast lesions by Mammotome® biopsy system. A series of 247 consecutive 8-gauge Mammotome® procedures were performed under ultrasound guidance and multivariate analysis was conducted. Read More

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http://dx.doi.org/10.1016/j.sjbs.2018.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319199PMC
January 2019

Fibroadenoma of the breast in a South African population -a pilot study of the diagnostic accuracy of fine needle aspirate cytology and breast ultrasonography.

Afr Health Sci 2018 Jun;18(2):273-280

University of Kwazulu-Natal, Discipline of Anaesthetics and Critical Care.

Background: The triple assessment of clinical breast exam (CBE), fine needle aspirate cytology (FNAC) and breast ultrasonography (US) is used in many settings for the diagnosis of fibroadenoma (FA). The diagnostic accuracy of FNAC and US for FA in South African (SA) women with palpable breast masses (PBM) is unknown.

Objective: To report the diagnostic accuracy of FNAC/US for FA in SA women with PBM. Read More

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http://dx.doi.org/10.4314/ahs.v18i2.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306964PMC

Breast diseases histologically diagnosed at a tertiary facility in Uganda (2005-2014).

BMC Cancer 2018 Dec 22;18(1):1285. Epub 2018 Dec 22.

Department of Pathology, Makerere University College of Health Sciences, Kampala, Uganda.

Background: The prevalence and distribution of histologically diagnosed breast disease are not well documented in low income countries, Uganda inclusive. Although the greater majority of breast lesions globally are benign, breast cancer is the most frequently diagnosed cancer all over the world. We aimed at documenting the prevalence of different breast diseases histologically diagnosed at the histopathology laboratory of the Department of Pathology of the Makerere University College of Health Sciences (MakCHS Lab) over a decade (2005-2014). Read More

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http://dx.doi.org/10.1186/s12885-018-5208-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303921PMC
December 2018
2 Reads
3.362 Impact Factor

Patients With Invasive Ductal Carcinoma Have Reduced Levels of Decorin Expression in Their Breast Tissue Compared to Patients With Fibroadenoma While Plasma Decorin Remains Unchanged.

Arch Iran Med 2018 Nov 1;21(11):509-517. Epub 2018 Nov 1.

Department of Genetics and Molecular Medicine, School of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran.

Background: Reduction in the level of tissue decorin is a hallmark of many types of cancer including breast carcinoma. However, reduced decorin expression has also been reported in several types of benign tumors to the extent that it has been proposed as a tissue marker to differentiate malignant from benign tumors. The aim of this study was to investigate the potential role of plasma decorin to distinguish breast cancer from fibroadenoma, the second most common type of benign tumor, after fibrocystic disease. Read More

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November 2018
1 Read
1.108 Impact Factor

Robust Short-Lag Spatial Coherence Imaging of Breast Ultrasound Data: Initial Clinical Results.

IEEE Trans Ultrason Ferroelectr Freq Control 2018 Nov 27. Epub 2018 Nov 27.

Ultrasound is frequently used in conjunction with mammography in order to detect breast cancer as early as possible. However, due largely to the heterogeneity of breast tissue, ultrasound images are plagued with clutter that obstructs important diagnostic features. Short-lag spatial coherence (SLSC) imaging has proven to be effective at clutter reduction in noisy ultrasound images. Read More

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http://dx.doi.org/10.1109/TUFFC.2018.2883427DOI Listing
November 2018
2 Reads

Management of Palpable Pediatric Breast Masses With Ultrasound Characteristics of Fibroadenoma: A More Conservative Approach.

AJR Am J Roentgenol 2019 Feb 26;212(2):450-455. Epub 2018 Nov 26.

1 Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

Objective: The purpose of this study is to describe our experience with pathologically proven breast masses at a tertiary care pediatric institution, review published management strategies, and propose new management recommendations for the pediatric population.

Materials And Methods: All pediatric breast ultrasound examinations performed at a dedicated pediatric facility over a 4-year period were reviewed. Maximum measurements of solid masses with features of a fibroadenoma were recorded. Read More

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https://www.ajronline.org/doi/10.2214/AJR.17.19482
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http://dx.doi.org/10.2214/AJR.17.19482DOI Listing
February 2019
7 Reads

A computer-aided diagnosis scheme of breast lesion classification using GLGLM and shape features: Combined-view and multi-classifiers.

Phys Med 2018 Nov 24;55:61-72. Epub 2018 Oct 24.

Department of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong 510515, China; Guangzhou Key Laboratory of Medical Radiation Imaging and Detection Technology, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:

Purpose: To address high false-positive results of FFDM issue, we make the first effort to develop a computer-aided diagnosis (CAD) scheme to analyze and distinguish breast lesions.

Method: The breast lesion regions were first segmented and depicted on FFDM images from 106 patients. In this work, 11 gray-level gap-length matrix texture features and 12 shape features were extracted form craniocaudal view and mediolateral oblique view, and then Student's t-test, Fisher-score and Relief-F were introduced to select features. Read More

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http://dx.doi.org/10.1016/j.ejmp.2018.10.016DOI Listing
November 2018

Recurrent exon 2 mutations in benign breast fibroepithelial lesions in adolescents and young adults.

J Clin Pathol 2018 Nov 22. Epub 2018 Nov 22.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Aims: Most benign breast fibroepithelial lesions (FEL) in adults harbour recurrent somatic exon 2 mutations and rare promoter hotspot mutations. We sought to determine the frequency of exon 2 and promoter hotspot mutations in fibroadenomas (FA) and benign phyllodes tumours (BePT) in adolescents and young adults.

Methods: DNA from 21 consecutive FAs and eight consecutive BePTs in adolescents and young adults was subjected to Sanger sequencing of the exon 2 of and the promoter hotspot locus. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205570DOI Listing
November 2018
11 Reads

Intermediate and long-term outcomes of fibroadenoma excision in adolescent and young adult patients.

Breast J 2019 Jan 16;25(1):91-95. Epub 2018 Nov 16.

Division of General Internal Medicine, Mayo Clinic, Rochester, Minnesota.

Fibroadenomas are benign breast masses that often occur in adolescence and young adulthood. Primary management options include observation or surgical excision, but little is known about long-term outcomes after fibroadenoma excision in adolescents. In the present study, we reviewed the medical records of females aged 13-35 years who underwent fibroadenoma excision at our institution from 1986 through 2010. Read More

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http://doi.wiley.com/10.1111/tbj.13159
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http://dx.doi.org/10.1111/tbj.13159DOI Listing
January 2019
10 Reads

Cytological Findings in Benign Phyllodes Tumors.

Acta Cytol 2018 Oct 26:1-5. Epub 2018 Oct 26.

Objective: Phyllodes tumors are fibroepithelial breast lesions with many cytological and histopathological similarities to fibroadenomas. The aim of this study was to investigate cytological findings in benign phyllodes tumors.

Study Design: Seventy-six histologically proven cases of benign phyllodes tumors were selected from 1982 to 2017. Read More

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http://dx.doi.org/10.1159/000493677DOI Listing
October 2018
3 Reads

HIFU treatment for fibroadenoma - a clinical study at National Scientific Research Centre, Astana, Kazakhstan.

J Pak Med Assoc 2018 Sep;68(9):1378-1380

Astana Medical University, Kazakhstan.

This randomized controlled study evaluated effect of low frequency high intensity focused ultrasound (HIFU) in 80 women with breast fibroadenomas randomly and evenly divided into main and control groups, treated with HIFU and sectoral resection accordingly. In- vitro trial of fibroadenoma samples exposed to different power levels:100 Watt (W), 200 W and 300 W, analysis of results shown that optimal ablation power 200W was enough for coagulation necrosis of tumour, while 300W ablation caused complete destruction of tissues. Results showed that 20% of control group (surgically treated) patients had post-operative complications and 12. Read More

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September 2018
17 Reads

Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment.

Surg Innov 2018 Oct 7:1553350618803245. Epub 2018 Oct 7.

3 Johns Hopkins Hospital, Baltimore, MD, USA.

Purpose: Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Read More

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http://journals.sagepub.com/doi/10.1177/1553350618803245
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http://dx.doi.org/10.1177/1553350618803245DOI Listing
October 2018
7 Reads

A Prospective Observational Study of Breast Lumps in Adolescent Girls: Tertiary Care South Indian Teaching Hospital Experience.

Indian J Surg Oncol 2018 Sep 18;9(3):402-406. Epub 2018 May 18.

M.S.Ramaiah Medical College, MSR Nagar, Gokula post, Bangalore, 560054 India.

The aim of the current study was to assess the incidence and varying clinical presentations of benign breast lumps in adolescent age group in a Tertiary care Medical College Hospital. This was a prospective, observational study of 6-year duration (2011 to 2017) conducted in a Medical College, South India. All adolescent age group patients visiting the outpatient department (OPD) with complaints of breast lump were enrolled into the study. Read More

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http://link.springer.com/10.1007/s13193-018-0773-3
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http://dx.doi.org/10.1007/s13193-018-0773-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154352PMC
September 2018
4 Reads

Fine needle aspiration biopsy cytology of phyllodes tumour and fibroadenoma: A cytomorphological study of 104 cases.

Diagn Cytopathol 2018 Nov 3;46(11):927-935. Epub 2018 Oct 3.

Westmead breast cancer institute, Westmead Hospital, Western Sydney Local Health District, Westmead, New South Wales, Australia.

Background: The cytomorphological features in the distinction between phyllodes tumour (PT) and fibroadenoma (FA) on fine needle aspiration biopsy (FNAB) remains challenging because of the biphasic nature of these lesions and the rarity of PT.

Methods: FNAB smears of histologically confirmed PT (N = 26) and FA (N = 78) cases were retrieved from a retrospective database interrogation from the Department of Cytology/Tissue Pathology, ICPMR Pathology West (Cerner Millennium) in Westmead Hospital. For each case, two smears were selected, de-identified and independently reviewed by four observers comprising two cytologists and two cytopathologists. Read More

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http://doi.wiley.com/10.1002/dc.24021
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http://dx.doi.org/10.1002/dc.24021DOI Listing
November 2018
9 Reads

Surgery for giant tumours of the breast: a 15 year review.

S Afr J Surg 2018 Sep;56(3):9-15

Plastic and Reconstructive Surgeon in private practice.

Background: Giant tumours of the breast tend to occur in the adolescent age group. Racial predilection has been noted in the literature. The mass often occupies most of the breast, leading to its distortion. Read More

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September 2018
11 Reads

Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis.

Eur J Radiol Open 2018 24;5:165-170. Epub 2018 Sep 24.

Institute for Diagnostic and Interventional Radiology, University Hospital of Zurich, Switzerland.

Purpose: To evaluate the accuracy of a deep learning software (DLS) in the discrimination between phyllodes tumors (PT) and fibroadenomas (FA).

Methods: In this IRB-approved, retrospective, single-center study, we collected all ultrasound images of histologically secured PT (n = 11, 36 images) and a random control group with FA (n = 15, 50 images). The images were analyzed with a DLS designed for industrial grade image analysis, with 33 images withheld from training for validation purposes. Read More

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http://dx.doi.org/10.1016/j.ejro.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154513PMC
September 2018
2 Reads

STEAP1 Inhibits Breast Cancer Metastasis and Is Associated With Epithelial-Mesenchymal Transition Procession.

Clin Breast Cancer 2019 Feb 30;19(1):e195-e207. Epub 2018 Aug 30.

Department of Maternal and Child Health, School of Public Health, Shandong University, Jinan, China. Electronic address:

Purpose: Six-transmembrane epithelial antigen of prostate 1 (STEAP1) is a cell surface antigen overexpressed in multiple cancers and is associated with malignancy and disease prognosis. The aims of this study were to evaluate STEAP1 expression in breast cancer and to determine the mechanisms involved.

Methods: STEAP1 expression was compared in normal breast tissue (n = 40), benign fibroadenoma (n = 52), and primary breast cancer (n = 211) using immunohistochemistry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15268209183037
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http://dx.doi.org/10.1016/j.clbc.2018.08.010DOI Listing
February 2019
7 Reads

Extracellular Matrix Imaging of Breast Tissue Pathologies by MALDI-Imaging Mass Spectrometry.

Proteomics Clin Appl 2019 Jan 14;13(1):e1700152. Epub 2018 Dec 14.

Department of Cell and Molecular Pharmacology, MUSC Proteomics Center, Medical University of South Carolina, Charleston, SC, 29425.

Purpose: A new method accessing proteins from extracellular matrix by imaging mass spectrometry (ECM IMS) has been recently reported. ECM IMS is evaluated for use in exploring breast tissue pathologies.

Experimental Design: A tissue microarray (TMA) is analyzed that has 176 cores of biopsies and lumpectomies spanning breast pathologies of inflammation, hyperplasia, fibroadenoma, invasive ductal carcinoma, and invasive lobular carcinoma and normal adjacent to tumor (NAT). Read More

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http://doi.wiley.com/10.1002/prca.201700152
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http://dx.doi.org/10.1002/prca.201700152DOI Listing
January 2019
15 Reads

Stromal Cellular Fragments in Breast Fine Needle Aspirates: Think Outside of the Box.

Acta Cytol 2018 24;62(5-6):450-455. Epub 2018 Sep 24.

Pathology Department, Faculdade de Medicina da Universidade do Porto, Porto,

Background: The presence of highly cellular stromal fragments in breast fine needle aspirates (FNA) suggests some classical differential diagnoses such as cellular fibroadenoma, phyllodes tumour (PT), metaplastic carcinomas, and some mesenchymal/myoepithelial proliferations. The other components of the smears can help in the differential diagnosis, but the presence of a low-grade epithelial proliferation does not always represent a fibro-epithelial lesion as we demonstrate in these two cases.

Cases: We discuss two cases of breast FNA, previously presented in a slide seminar at the 29th European Congress of Pathology in Amsterdam, where the common cytological finding was the presence of stromal cellular fragments together with an epithelial component. Read More

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https://www.karger.com/Article/FullText/492566
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http://dx.doi.org/10.1159/000492566DOI Listing
January 2019
12 Reads

Breast MRI findings of fibroadenoma with hemorrhagic infarction.

Breast J 2018 Nov 21;24(6):1078-1079. Epub 2018 Sep 21.

Department of Radiology, Faculty of Medicine, Saga University, Saga, Japan.

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http://doi.wiley.com/10.1111/tbj.13137
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http://dx.doi.org/10.1111/tbj.13137DOI Listing
November 2018
1 Read

A longitudinal study of the prevalence and characteristics of breast disorders detected by clinical breast examination during pregnancy and six months postpartum in Ibadan, Southwestern Nigeria.

BMC Womens Health 2018 Sep 19;18(1):152. Epub 2018 Sep 19.

Centre for Population and Reproductive Health, College of Medicine, Ibadan, Nigeria.

Background: Breast disorders cause great anxiety for women especially when they occur in pregnancy because breast cancer is the most common cause of cancer related deaths in women. Majority of the disorders are Benign Breast Diseases (BBD) with various degrees of associated breast cancer risks. With increasing breast cancer awareness in Nigeria, we sought to determine the prevalence and characteristics of breast disorders among a cohort of pregnant women. Read More

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http://dx.doi.org/10.1186/s12905-018-0647-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6147054PMC
September 2018
5 Reads

MED12 somatic mutations encompassing exon 2 associated with benign breast fibroadenomas and not breast carcinoma in Indian women.

J Cell Biochem 2019 Jan 19;120(1):182-191. Epub 2018 Sep 19.

Department of Genetics and Molecular Medicine, Kamineni Hospitals, Hyderabad, India.

Fibroadenoma is the most common type of benign breast tumor, accounting for 90% of benign lesions in India. Somatic mutations in the mediator complex subunit 12 (MED12) gene play a critical role in fibroepithelial tumorigenesis. The current study evaluated the hotspot region encompassing exon 2 of the MED12 gene, in benign and malignant breast tumor tissue from women who presented for breast lump evaluation. Read More

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http://dx.doi.org/10.1002/jcb.27293DOI Listing
January 2019
2 Reads

High intensity focused ultrasound (HIFU) for the treatment of symptomatic breast fibroadenoma.

Int J Hyperthermia 2018 11;35(1):463-470. Epub 2018 Sep 11.

a Department of Women's Health , University Hospital of Tuebingen , Tuebingen , Germany.

Purpose: The aim of the study was to evaluate the efficacy of high intensity focused ultrasound (HIFU) in the treatment of symptomatic breast fibroadenomas (FA) after 6 and 12 months.

Materials And Methods: Between December 2013 and November 2014, 27 patients with histologically confirmed FA received one application of HIFU under local anesthesia (NCT02011919). Follow-up visits occurred after 6 and 12 months measuring the FA volume and clinical symptoms. Read More

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https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1
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http://dx.doi.org/10.1080/02656736.2018.1508757DOI Listing
September 2018
11 Reads

Radiomics of US texture features in differential diagnosis between triple-negative breast cancer and fibroadenoma.

Sci Rep 2018 Sep 10;8(1):13546. Epub 2018 Sep 10.

Department of Radiology, Severance Hospital, Research Institute of Radiological Science and Center for Clinical Image Data Science, Yonsei University College of Medicine, Seoul, Korea.

Triple-negative breast cancer (TNBC) is sometimes mistaken for fibroadenoma due to its tendency to show benign morphology on breast ultrasound (US) albeit its aggressive nature. This study aims to develop a radiomics score based on US texture analysis for differential diagnosis between TNBC and fibroadenoma, and to evaluate its diagnostic performance compared with pathologic results. We retrospectively included 715 pathology-proven fibroadenomas and 186 pathology-proven TNBCs which were examined by three different US machines. Read More

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http://dx.doi.org/10.1038/s41598-018-31906-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131410PMC
September 2018
7 Reads

Pseudoaneurysm associated with arteriovenous fistula involving a superficial breast arteriole after vacuum-assisted removal of a benign mass: A case report.

Medicine (Baltimore) 2018 Sep;97(36):e12250

Department of Breast and Thyroid Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

Rationale: Pseudoaneurysm (PA) with associated arteriovenous fistula (AVF) is most often secondary to vascular catheterization, percutaneous biopsy, surgery, or trauma. PA-AVF occurs mainly in large or median arterial territories but rarely in the superficial arterioles of the breast.

Patient Concerns: A 30-year-old woman underwent vacuum-assisted removal of breast fibroadenomas under ultrasonic guidance. Read More

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http://dx.doi.org/10.1097/MD.0000000000012250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133411PMC
September 2018
5 Reads

Breast Lesions in Children and Adolescents: Diagnosis and Management.

Korean J Radiol 2018 Sep-Oct;19(5):978-991. Epub 2018 Aug 6.

Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.

Pediatric breast disease is uncommon, and primary breast carcinoma in children is extremely rare. Therefore, the approach used to address breast lesions in pediatric patients differs from that in adults in many ways. Knowledge of the normal imaging features at various stages of development and the characteristics of breast disease in the pediatric population can help the radiologist to make confident diagnoses and manage patients appropriately. Read More

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http://dx.doi.org/10.3348/kjr.2018.19.5.978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082765PMC
August 2018
15 Reads

Fibroadenomas and breast carcinoma: a possible answer to a frequently asked question. A pictorial essay.

Med Ultrason 2018 Aug;20(3):385-391

Emergency University Conty Hospital Cluj-Napoca.

Fibroadenomas (FAs) are the most frequently encountered benign breast lesions in young women and due to the age of the patients, they are usually diagnosed by ultrasound. Although they rarely undergo malignant transformation, the patients remain concerned about the possibility of malignant transformation. The aim of this pictorial essay is to illustrate the appearance of classic and complex fibroadenomas, to discuss the risk factors and to highlight the imaging characteristics that raise the suspicion of malignant transformation. Read More

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http://dx.doi.org/10.11152/mu-1408DOI Listing
August 2018
1 Read

Educational Case: Fibroadenoma of the Breast.

Authors:
H James Williams

Acad Pathol 2018 Jan-Dec;5:2374289518790926. Epub 2018 Aug 24.

West Virginia University Health Sciences Center, Morgantown, WV, USA.

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals. Read More

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http://dx.doi.org/10.1177/2374289518790926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109836PMC
August 2018
1 Read

Tubular adenomas of the breast: a rare diagnosis.

BMJ Case Rep 2018 Aug 27;2018. Epub 2018 Aug 27.

Department of Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA.

Tubular adenomas of the breast are rare benign tumours and few cases have been reported. Most often, the tumours are described as palpable, well-circumscribed masses in women of childbearing age and are commonly diagnosed as fibroadenomas both clinically and radiographically. Surgical excision is required for diagnosis and to prevent continuing growth. Read More

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http://dx.doi.org/10.1136/bcr-2018-224631DOI Listing
August 2018
1 Read

Case Report and Review of Adolescent Atypical Ductal Hyperplasia and Juvenile Fibroadenoma: How Do We Assess and Manage Future Risk?

Clin Breast Cancer 2018 Oct 5;18(5):e751-e754. Epub 2018 Jul 5.

Division of Breast Surgery, MD Anderson Cancer Center at Cooper University Health Care, Camden, NJ.

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http://dx.doi.org/10.1016/j.clbc.2018.07.001DOI Listing
October 2018
11 Reads

Scinderin-knockdown inhibits proliferation and promotes apoptosis in human breast carcinoma cells.

Oncol Lett 2018 Sep 21;16(3):3207-3214. Epub 2018 Jun 21.

Department of Thyroid and Breast Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China.

Previous studies have reported that scinderin (SCIN) affects multiple cellular processes, including proliferation, migration and differentiation in cancer. However, the specific role of SCIN in breast cancer (BC) cells is unknown. Immunohistochemistry was used to investigate SCIN expression in 46 BC and 21 mammary fibroadenoma or fibroadenomatoid hyperplasia tissue samples. Read More

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http://dx.doi.org/10.3892/ol.2018.9009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6096137PMC
September 2018
2 Reads

[Association of CYP19A1 gene rs7176005 single nucleotide polymorphism with breast cancer risk and clinicopathologic features of tumor].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Aug;52(8):827-832

Department of Breast Surgery, West China Hospital of Sichuan University, Sichuan 610041, China.

The aim of this study was to investigate the association of the CYP19A1 rs7176005 single nucleotide polymorphism (SNP) with breast cancer risk and with clinicopathologic features of tumors. This study was conducted by including 138 patients with breast cancer (cancer group), those who diagnosed as primary breast cancer after operation by pathology. There were 293 cases in the group of benign breast disease which was presented as a solid mass by the color ultrasound and pathologically diagnosed as "fibroadenoma or adenosis" (benign breast disease group), the cases were paired with breast cancer patients by age±5 in the same period, and there were 259 cases in the group of healthy control who received routine physical examination during the same period and were paired with breast cancer patients by age±5 without any detection of breast related diseases (healthy control group) at West China hospital between September 2012 and November 2016. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2018.08.010DOI Listing
August 2018
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Breast fibroadenomas are not associated with increased breast cancer risk in an African American contemporary cohort of women with benign breast disease.

Breast Cancer Res 2018 08 9;20(1):91. Epub 2018 Aug 9.

Department of Oncology, Wayne State University School of Medicine, 4100 John R Street, MM04EP, Detroit, MI, 48201, USA.

Background: Fibroadenomas are common benign breast lesions, and studies of European American women indicate a persistent, increased risk of breast cancer after diagnosing a fibroadenoma on biopsy. This association has not been independently assessed in African American women, despite reports that these women are more likely to present with fibroadenomas.

Methods: The study cohort included 3853 African American women with a breast biopsy completed between 1997 and 2010 in metropolitan Detroit. Read More

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http://dx.doi.org/10.1186/s13058-018-1027-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6085691PMC
August 2018
13 Reads

[Ectopia of mammary tissue].

Pathologe 2018 Sep;39(5):398-401

Institut für Pathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Ectopic breast tissue may represent the complete breast (accessory breast), glandular tissue without areola or nipple (aberrant breast tissue), or exclusively the nipple (polythelia). Localization is along the embryonic milk ridge extending from the axilla to the vulva. Only rarely, is ectopic tissue found outside of the milk ridge. Read More

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http://link.springer.com/10.1007/s00292-018-0468-0
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http://dx.doi.org/10.1007/s00292-018-0468-0DOI Listing
September 2018
15 Reads

A comprehensive clinicopathological evaluation of the differential expression of microRNA-331 in breast tumors and its diagnostic significance.

Clin Biochem 2018 Sep 29;60:24-32. Epub 2018 Jul 29.

Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, Greece. Electronic address:

Objective: MicroRNA-331 (miR-331) has shown regulatory activity against several genes whose expression has been claimed to be deregulated in breast tumors, including that of epidermal growth factor receptor 2 (HER2). Herein, the clinical value of miR-331 expression was investigated by analyzing its levels in breast benign and malignant tumors.

Methods: The expression levels of miR-331 were quantified via real-time PCR in 130 malignant and 66 benign breast tissue specimens collected after surgical resection of primary tumors. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2018.07.008DOI Listing
September 2018
2 Reads

Effectivity of combined diffusion-weighted imaging and contrast-enhanced MRI in malignant and benign breast lesions.

Pol J Radiol 2018 15;83:e82-e93. Epub 2018 Feb 15.

Department of Radiology and Imaging, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune, India.

Purpose: Mammography is the most commonly used diagnostic test for breast lesion detection and evaluation, but in dense breast parenchyma it lowers its sensitivity to detect small lesions. Sensitivity and specificity improves with combined use of contrast-enhanced magnetic resonance imaging (CE-MRI) and diffusion-weighted imaging (DWI) in differentiating benign and malignant breast lesions. The aim of the study was to evaluate the effectivity of combined dynamic CE-MRI and DWI in differentiating benign and malignant lesions, and to calculate the apparent diffusion coefficient (ADC) values of malignant and benign lesions of the breast. Read More

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http://dx.doi.org/10.5114/pjr.2018.74363DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047092PMC
February 2018
15 Reads

Cellular fibroepithelial lesions of the breast: A long term follow up study.

Ann Diagn Pathol 2018 Aug 10;35:85-91. Epub 2018 Jan 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Some fibroepithelial lesions (FEL) of the breast are difficult to classify as cellular fibroadenoma (CFA) or benign phyllodes tumor (BPT) due to overlapping histologic features. This indeterminate group is histologically characterized by prominent stromal cellularity, mild atypia, and mitotic activity. The local recurrence potential of cellular FEL (CFEL) has been insufficiently studied. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.01.005DOI Listing
August 2018
28 Reads

Significance and prognosis of epithelial-cadherin expression in invasive breast carcinoma.

Oncol Lett 2018 Aug 30;16(2):1659-1665. Epub 2018 May 30.

Department of Breast Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830011, P.R. China.

The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer. The immunohistochemical streptavidin-peroxidase method was used to detect the E-cadherin expression in 30 cases of breast fibroadenoma and in 450 cases of invasive breast cancer, and then the χtest and Kaplan-Meier method were used to analyze the data. The 30 cases of breast fibroadenoma showed positive expression of E-cadherin. Read More

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http://dx.doi.org/10.3892/ol.2018.8836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036376PMC
August 2018
8 Reads

Acellular dermal matrix for breast reconstruction after surgery for giant dermatofibrosarcoma protuberans.

Ann Ital Chir 2018 Jul 12;7. Epub 2018 Jul 12.

Introduction: Dermatofibrosarcoma protuberans (DFSP) is a rare neoplasm that exceptionally can affect the breast, always originating from skin and dermis, so imposing large sacrifice of skin. Only few cases have been reported of intraparenchymal DFS. We describe a unique case of giant intraparenchymal DFS that required removal of all the gland and reconstructive surgery. Read More

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July 2018
17 Reads