3,230 results match your criteria Breast Fibroadenoma


Fibroadenoma versus phyllodes tumor: a vexing problem revisited!

BMC Cancer 2020 Jul 13;20(1):648. Epub 2020 Jul 13.

Department of Microbiology, All India Institute of Medical Sciences, Mangalagiri, 522503, Andhra Pradesh, India.

Background: Fibroepithelial lesions of the breast include fibroadenoma (FA) and phyllodes tumor (PT). Fibroadenomas are benign while phyllodes tumor range from benign, indolent neoplasms to malignant tumors capable of distant metastasis. Our study was to determine the select cytologic features that can accurately distinguish FA from PT. Read More

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http://dx.doi.org/10.1186/s12885-020-07129-0DOI Listing

A case report of fibroadenoma of the breast with characteristic cystic change on a cut surface.

SAGE Open Med Case Rep 2020 24;8:2050313X20927612. Epub 2020 Jun 24.

Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, Japan.

Fibroadenoma with remarkable cystic change is very unusual. Opinions differ as to the interpretation of this lesion. Furthermore, there have been few reports focusing on its macroscopic view. Read More

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http://dx.doi.org/10.1177/2050313X20927612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318826PMC

A Bethesda-like system for breast cytopathology: A retrospective assessment two decades on.

Diagn Cytopathol 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, Missouri, USA.

Fine-needle aspiration biopsy (FNAB) has been used for many decades in the investigation of breast lesions. Originally, cases were signed out using the categories benign and malignant. The benign category contained specimens showing fibrocystic change as well as benign neoplasms such as fibroadenoma. Read More

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http://dx.doi.org/10.1002/dc.24483DOI Listing

Histopathologic, immunophenotypic, and proteomics characteristics of low-grade phyllodes tumor and fibroadenoma: more similarities than differences.

NPJ Breast Cancer 2020 26;6:27. Epub 2020 Jun 26.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA.

Distinguishing low-grade phyllodes tumor from fibroadenoma is practically challenging due to their overlapping histologic features. However, the final interpretation is essential to surgeons, who base their management on the final pathology report. Patients who receive a diagnosis of fibroadenoma might not undergo any additional intervention while lumpectomy with wide margins is the standard of care for phyllodes tumor, which can have significant cosmetic consequences. Read More

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http://dx.doi.org/10.1038/s41523-020-0169-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319981PMC

The prognostic significance of GRB7 protein expression and localization in human breast and ovarian cancers.

Oncotarget 2020 Jun 16;11(24):2273-2289. Epub 2020 Jun 16.

Hospital & Specialty Medicine, VA Portland Health Care System, Portland, OR, USA.

To study GRB7 protein expression in normal human tissues and breast and ovarian cancers, and determine its clinical significance. GRB7 protein was expressed in multiple tissues, including myoepithelial cells of normal breast and fibroadenoma. Cytoplasmic GRB7 expression was seen predominantly in HER-2 positive and, to a lesser extent, triple negative breast cancer. Read More

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http://dx.doi.org/10.18632/oncotarget.27593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299530PMC

Lesions of anogenital mammary-like glands: Four cases including novel pathologic and immunohistochemical observations.

Ann Diagn Pathol 2020 Jun 17;47:151551. Epub 2020 Jun 17.

Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX, USA. Electronic address:

Anogenital mammary-like glands, formerly described as ectopic breast tissue, are currently considered to be normal histologic components of the anogenital region. Anogenital mammary-like glands can give rise to many lesions identical to counterparts in the native female breast. We describe four cases of such lesions, including fibroadenoma, gynecomastia-like hyperplasia, and ectopic mammary-type tissue with a spectrum of usual ductal hyperplasia, apocrine metaplasia, adenosis, and pseudolactational change. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2020.151551DOI Listing

RCC2 Expression Stimulates ER-Positive Breast Tumorigenesis.

J Oncol 2020 23;2020:5619462. Epub 2020 May 23.

Medical Research Center of The Affiliated Hospital of Qingdao University, Wutaishan Road 1677, Qingdao, Shandong 266000, China.

Objective: Regulator of chromosome condensation 2 (RCC2) has been reported to be involved in the regulation of cell cleavage. This study investigated the effect of RCC2 expression on breast tumorigenesis.

Methods: MCF-7 cells originating from estrogen receptor-positive (ER+) breast cancer were transfected with anti-RCC2 siRNA or RCC2-expressing plasmids. Read More

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http://dx.doi.org/10.1155/2020/5619462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262660PMC

Fine-needle aspiration findings of fibroadenoma with pseudolactational changes in the vulva: A case report.

Diagn Cytopathol 2020 Jun 19. Epub 2020 Jun 19.

Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran.

Fibroadenoma is a common benign neoplasm of the breast and ectopic breast tissue, associated with possible lactational changes in pregnant or lactating women. Uncommon pseudolactational changes are possible in this neoplasm among nulliparous women. Fibroadenoma and lactating adenoma are rarely seen in the vulvar region. Read More

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http://dx.doi.org/10.1002/dc.24527DOI Listing

Quantitative chemical imaging of breast calcifications in association with neoplastic processes.

Theranostics 2020 27;10(13):5865-5878. Epub 2020 Apr 27.

Department of Chemistry, University of Washington, Seattle, 98195-1700, USA.

Calcifications play an essential role in early breast cancer detection and diagnosis. However, information regarding the chemical composition of calcifications identified on mammography and histology is limited. Detailed spectroscopy reveals an association between the chemical composition of calcifications and breast cancer, warranting the development of novel analytical tools to better define calcification types. Read More

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http://dx.doi.org/10.7150/thno.43325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254998PMC

Role Of Fine Needle Aspiration Cytology In Diagnosis Of Palpable Breast Lesions And Their Comparison With Histopathology.

J Ayub Med Coll Abbottabad 2020 Jan- Mar;32(1):83-86

Department of Anatomy, Bannu Medical College, Bannu, Pakistan.

Background: The aim of this study was to compare the diagnostic utility of fine needle aspiration cytology (FNAC) in breast lesion with gold standard of histopathological diagnosis.

Methods: This descriptive cross-sectional study was conducted in Pathology department of Bannu Medical College in collaboration with Surgery Department of Khalifa Gul Nawaz Teaching Hospital Bannu as well as other private surgical hospitals of the territory. A total of 88 FNAC of palpable breast lesions were performed and compared with their corresponding histopathological reports. Read More

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Fibroepithelial lesions revisited: implications for diagnosis and management.

Authors:
Puay Hoon Tan

Mod Pathol 2020 May 27. Epub 2020 May 27.

Division of Pathology, Singapore General Hospital, Academia, Diagnostics Tower Level 7, 20 College Road, Singapore, 169856, Singapore.

Fibroepithelial lesions of the breast, comprising the fibroadenoma and phyllodes tumour, are a unique group of neoplasms that share histological characteristics but possess different clinical behaviour. The fibroadenoma is the commonest benign breast tumour in women, while the phyllodes tumour is rare and may be associated with recurrences, grade progression and even metastasis. The diagnosis of fibroadenoma is usually straightforward, with recognised histological variants such as the cellular, complex, juvenile and myxoid forms. Read More

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http://dx.doi.org/10.1038/s41379-020-0583-3DOI Listing

Expression of Nrf2 and NF-κB transcription factors in breast cancer and breast fibroadenoma: Insights for a new therapeutic approach.

Oncotarget 2020 May 5;11(18):1629-1636. Epub 2020 May 5.

Postgraduate Program, Northeast Biotechnology Network (RENORBIO), Department of Health, Federal University of Piauí, Teresina, Piauí 64000-020, Brazil.

Cancer and fibroadenoma are the most common breast tumors in women of reproductive age. Nuclear factor erythroid 2-related factor 2 (Nrf2) and the nuclear factor kappaB (NF-κB) transcription factor play an important role in the inflammatory process and in cell proliferation. However, few studies have analyzed these markers in breast cancer and fibroadenoma in women of reproductive age. Read More

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http://dx.doi.org/10.18632/oncotarget.27574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210014PMC

Cellular fibroepithelial lesions diagnosed on core needle biopsy: Is there any role of clinical-sonography features helping to differentiate fibroadenomas and phyllodes tumor?

J Surg Oncol 2020 May 12. Epub 2020 May 12.

Joint Department of Medical Imaging, Mount Sinai Hospital, Women's College Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada.

Objective: The purpose of this study is to determine the role of clinico-sonographic features of breast cellular fibroepithelial lesions (CFELs) diagnosed on core needle biopsy (CNB) in the differentiation between fibroadenoma (FA) and phyllodes.

Materials And Methods: Results of consecutive women with a CNB showing CFEL from 2005 to 2010 were retrospectively reviewed. Clinical and sonographic findings were compared with surgical outcomes. Read More

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http://dx.doi.org/10.1002/jso.25977DOI Listing

Giant fibroma of breast in an adolescent female by inverted "T" incision: A case report and literature review.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Feb;45(2):204-207

Department of Breast and Thyroid Surgery, Central South University Xiangya School of Mediccine Affiliated Haikou Hospital, Haikou 570000, China.

Giant fibroma of the breast in adolescence is a benign tumor of the breast that occurs in a special period in women, often in adolescent women aged 18-25 years old. These tumors are characterized by short course and large size. They are rare in clinic and easy to be misdiagnosed. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2020.180529DOI Listing
February 2020

[Phyllodes Tumor of the Breast Occurring near Postoperative Fibroadenoma Scar-A Case Report].

Gan To Kagaku Ryoho 2020 Jan;47(1):150-152

Dept. of Surgery, Nippon Dental University Hospital.

We report the case of a phyllodes tumor of the breast occurring near a postoperative scar of fibroadenoma of the breast. The patient was a 41-year-old female who had a lump in the left breast, and underwent surgical resection of the tumor 5 years ago at another hospital.The pathological diagnosis of the tumor was fibroadenoma, and surgical margin was negative. Read More

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January 2020

Fibroadenoma in Ectopic Breast Tissue of Axilla: A Rare Entity.

J Med Ultrasound 2020 Jan-Mar;28(1):50-51. Epub 2019 Dec 10.

Department of Medicine, INHS Sanjeevani, Ernakulam, Kerala, India.

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http://dx.doi.org/10.4103/JMU.JMU_65_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194415PMC
December 2019

Texture Analysis of Ultrasound Images to Differentiate Simple Fibroadenomas From Complex Fibroadenomas and Benign Phyllodes Tumors.

J Ultrasound Med 2020 Apr 24. Epub 2020 Apr 24.

Department of Radiology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Objectives: American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions can be distinguished from BI-RADS 3 lesions with main ultrasound (US) findings such as a well-defined contour, round/oval shape, and parallel orientation with a homogeneous echo pattern. Breast Imaging Reporting and Data System 4A solid masses might be diagnosed as simple fibroadenomas (SFAs), complex fibroadenomas (CFAs), or benign phyllodes tumors (BPTs). Complex fibroadenomas have an increased risk of invasive cancer development than SFAs, and BPTs have a risk of borderline-malignant phyllodes tumor transformation; both of them are surgically treated, whereas follow-up procedures are applied in SFAs. Read More

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http://dx.doi.org/10.1002/jum.15304DOI Listing

Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study.

Mod Pathol 2020 Apr 22. Epub 2020 Apr 22.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

Breast fibroepithelial lesions (FELs) encompass the common fibroadenoma (FA) and relatively rare phyllodes tumour (PT); the latter entity is usually classified as benign, borderline or malignant. Intratumoural heterogeneity is frequently present in these tumours, making accurate histologic evaluation challenging. Despite their rarity, PTs are an important clinical problem due to their propensity for recurrence and, in the case of malignant PT, metastasis. Read More

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http://dx.doi.org/10.1038/s41379-020-0533-0DOI Listing
April 2020
6.187 Impact Factor

Anomalies in milk line: Case report of two cases.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):319-321

Department of Pathology, VIMS, Gajraula, Uttar Pradesh, India.

Congenital anomalies of breast, especially polymastia and polythelia, confuse clinicians because of their varied presentations, associated renal anomalies, and pathologies arising in them. Case 1: A 30-year-old Asian Indian female presented with swelling in left inguinal region since 2 years, increased in size in last 2 months with history of milk discharge. Diagnosis of ectopic breast tissue inguinal region with lactational changes was made on fine-needle aspiration cytology (FNAC). Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_281_18DOI Listing

A retrospective evaluation of pediatric breast fibroadenomas with mid-term follow-up results.

Breast J 2020 Apr 12. Epub 2020 Apr 12.

Department of Pediatric Surgery, Istanbul Medeniyet University Goztepe Training and Research Hospital, Istanbul, Turkey.

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http://dx.doi.org/10.1111/tbj.13834DOI Listing

Fibroadenoma containing lobular carcinoma , an unusual finding in a normally benign mass.

J Surg Case Rep 2020 Apr 7;2020(4):rjaa059. Epub 2020 Apr 7.

Advanced Surgical Associates, 3460 NE Ralph Powell Rd. Lee's Summit, MO 64064, USA.

This is the case of a 27-year-old female who underwent breast lumpectomy for fibroadenoma of the left breast. Pathologic evaluation of the specimen revealed lobular carcinoma (LCIS) entirely confined to a large fibroadenoma without LCIS in the surrounding breast tissue. Read More

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http://dx.doi.org/10.1093/jscr/rjaa059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136718PMC

Main Traits of Breast Fibroadenoma Among Adolescent Girls.

Cancer Biother Radiopharm 2020 May 8;35(4):271-276. Epub 2020 Apr 8.

Department of Information, Tongzhou Maternal and Child Health Hospital of Beijing, Beijing, China.

To investigate the clinicopathological features of breast fibroadenoma among female teenagers and provide some bases for its diagnosis and treatment, the authors conducted this study. Retrospective analysis on 80 female teenagers with fibroadenoma was carried out. The histological sections of H&E were reviewed, and immunohistochemical staining with ki67, CD34, and SMA were performed. Read More

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http://dx.doi.org/10.1089/cbr.2019.3209DOI Listing

Langerhans cell histiocytosis of an intra-mammary lymph node in an 18-year-old woman.

Pathologica 2020 Mar;112(1):50-55

Department of Pathology, ASST Cremona, Italy.

We describe an 18-year-old woman with several month's history of a 12 x 7 mm palpable mammary nodule, that was hypoechoic, with regular margins and vascularization areas by ultrasound. A fibroadenoma was hypothesized (American College of Radiology BI-RADS 3). A 14 G needle biopsy was performed, showing a LC proliferation suspected for LCH of a lymph node, with florid dermatopathic lymphadenopathy in differential diagnosis. Read More

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http://dx.doi.org/10.32074/1591-951X-27-19DOI Listing

Locally advanced triple negative breast cancer arising from fibroadenoma with complete response to neoadjuvant chemotherapy: A case report.

Int J Surg Case Rep 2020 29;68:234-238. Epub 2020 Feb 29.

Department of Breast Surgery, National Cancer Center Hospital, Tokyo 104-0045, Japan; National Hospital Organization Tokyo Medical Center, Tokyo 152-8902, Japan.

Introduction: Breast cancer arising from benign fibroadenoma (FA) is rare. The histological type of the former was either carcinoma in situ or early-stage invasive breast carcinoma with hormone receptor positive/HER2 (human epidermal growth factor receptor-2)-negative phenotype. Meanwhile, advanced breast cancer of triple negative (TN) phenotype such as our case is extremely uncommon and clinically challenging. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.02.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078443PMC
February 2020

Association analyses of a genetic variant in long non-coding RNA MEG3 with breast cancer susceptibility and serum MEG3 expression level in the Egyptian population.

Cancer Biomark 2020 ;28(1):49-63

Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Background: LncRNA MEG3 rs7158663 has been shown to confer cancer susceptibility, maybe through altering its gene expression level.

Objective: We aimed to weigh the effect of rs7158663 on MEG3 serum level and breast cancer susceptibility.

Methods: We genotyped rs7158663 G > A and measured serum MEG3 in 150 breast cancer, 95 fibroadenoma , and 154 controls by the TaqMan method. Read More

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http://dx.doi.org/10.3233/CBM-191072DOI Listing
January 2020
1.186 Impact Factor

Mammotome-assisted removal with minimal incision of large juvenile fibroadenoma of breast: A case report.

Medicine (Baltimore) 2020 Mar;99(10):e19442

Department of General Surgery, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, Zhejiang, China.

Introduction: Giant juvenile breast fibroadenoma can cause deformity and should be excised. Cosmesis is an important consideration in young patients.

Patient Concerns: The patient was admitted to our hospital for a mass of 6 × 6 cm in her left breast. Read More

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http://dx.doi.org/10.1097/MD.0000000000019442DOI Listing

A Radiomics Approach for the Classification of Fibroepithelial Lesions on Breast Ultrasonography.

Ultrasound Med Biol 2020 May 24;46(5):1133-1141. Epub 2020 Feb 24.

Department of Radiology, Research Institute of Radiological Science and Center for Clinical Image Data Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

A radiomics-based classifier to distinguish phyllodes tumor and fibroadenoma on gray-scale breast ultrasonography was developed and validated. A total of 93 radiomics features were extracted from representative transverse plane ultrasound images of 182 fibroepithelial lesions initially diagnosed by core needle biopsy. High-throughput radiomics features were selected using the intra-class correlation coefficient between two radiologist readers and the Least Absolute Shrinkage and Selection Operator regression through 10-fold cross-validation. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.01.015DOI Listing

Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer.

Pathology 2020 Apr 22;52(3):329-335. Epub 2020 Feb 22.

Department of Pathology, Shandong University, School of Basic Medical Sciences, Jinan, Shandong, PR China. Electronic address:

As a new member of Neks family, Nek9 regulates spindle assembly and controls chromosome alignment and centrosome separation. In the current study we aimed to investigate the expression of Nek9 in breast cancer and its clinical significance. We evaluated the expression of Nek9 in invasive ductal carcinoma (IDC, n=316), ductal carcinoma in situ (DCIS), usual ductal hyperplasia, atypical ductal hyperplasia, fibroadenoma and normal breast tissues using immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.pathol.2019.11.008DOI Listing
April 2020
2.188 Impact Factor

Breast disease in Timor-Leste.

ANZ J Surg 2020 Feb 16. Epub 2020 Feb 16.

School of Surgery and Pathology, The University of Western Australia, Perth, Western Australia, Australia.

Background: Surgically treatable conditions are well documented in high-income countries. There is a gap in epidemiological understanding of breast pathology in many developing countries, Timor-Leste among them. This study was conducted to determine the burden of breast disease and to inform public health measures to address early detection, diagnosis and management. Read More

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http://dx.doi.org/10.1111/ans.15720DOI Listing
February 2020

Characterizing excised breast masses in children and adolescents-Can a more aggressive pathology be predicted?

J Pediatr Surg 2020 Jan 29. Epub 2020 Jan 29.

Department of General Surgery, Shamir (Assaf Harofeh) Medical Center, Zerifin, Be'er Ya'akov, Israel, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: Our aim was to characterize excised breast masses in children and adolescent and to identify factors associated with a more aggressive pathology.

Methods: Retrospective review of all female patients <19 who underwent excision of breast masses at our institution between 1999 and 2018. Demographic, clinical, imaging, pathological and management data were collected. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.01.012DOI Listing
January 2020

Malignant Phyllodes Tumor of the Breast in a 26-year-old Woman.

Cureus 2020 Jan 7;12(1):e6590. Epub 2020 Jan 7.

Radiology, University of Texas Medical Branch, Galveston, USA.

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Early detection, accurate diagnosis and proper treatment are important prognostic factors due to the wide variety of breast cancer subtypes. This becomes of particular importance with rare breast tumors, which are difficult to diagnose due to their varying presentations. Read More

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http://dx.doi.org/10.7759/cureus.6590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001134PMC
January 2020

A Pre-operative Score to Discriminate Fibroepithelial Lesions of the Breast: Phyllode Tumor or Fibroadenoma?

Anticancer Res 2020 Feb;40(2):1095-1100

Department of Surgical Oncology, Rene Huguenin, Saint-Cloud, France.

Background/aim: Fibroepithelial lesions (FEL) of the breast include fibroadenomas and phyllodes tumors (PT). Their histologic characteristics on core needle biopsy can overlap, while their clinical management is different. The aim of this study was to develop and to validate a pre-operative score for the diagnosis of PT with surgical decision rules. Read More

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http://dx.doi.org/10.21873/anticanres.14048DOI Listing
February 2020

Fibroepithelial Lesions (FELs) of the Breast: Is Routine Excision Always Necessary?

World J Surg 2020 May;44(5):1552-1558

Department of Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, 420 East 70th St, Room 251, New York, NY, 10021, USA.

Background: When needle core biopsies (NCBs) of the breast reveal fibroepithelial lesions (FELs), excision is often performed to rule out a phyllodes tumor (PT), despite low malignancy rates. Consequently, the natural history of observed FELs is not well described. We analyzed the malignancy risk in excised FELs and the natural history of FELs undergoing active surveillance (AS). Read More

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http://dx.doi.org/10.1007/s00268-020-05385-6DOI Listing
May 2020
2.642 Impact Factor

Imaging and management of fibroepithelial breast lesions on percutaneous core needle biopsy.

Breast J 2020 Jun 10;26(6):1216-1220. Epub 2020 Jan 10.

Department of Radiology, Boston University School of Medicine, Boston, MA, USA.

The purpose of this study is to review the clinical presentation, multi-modality appearance, and management of the most common benign and malignant fibroepithelial lesions of the breast. Fibroepithelial lesions of the breast may exhibit characteristic features on mammography, ultrasound, and MRI, although definitive diagnosis most often requires biopsy and at times, surgical excision. Knowledge of the imaging features can assist in refining the differential diagnosis and guiding appropriate management. Read More

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http://dx.doi.org/10.1111/tbj.13749DOI Listing

Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience.

J Surg Oncol 2020 Mar 6;121(3):441-446. Epub 2020 Jan 6.

Department of Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background And Objectives: Giant juvenile fibroadenoma (GJF) is a rare benign tumor that disfiguring affects the breast shape and quality of life of patients. This study aimed to report the experience of GJF management.

Methods: A Wise-pattern skin reducing tumor resection followed by immediate breast reconstruction with a dermal flap pocket was used. Read More

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http://dx.doi.org/10.1002/jso.25828DOI Listing

Imaging of Lactating Adenoma: Differential Diagnosis of Solid Mass Lesion in a Lactating Woman.

J Med Ultrasound 2019 Oct-Dec;27(4):208-210. Epub 2019 Aug 7.

Department of Radiology, Holy Family Hospital, Idukki, Kerala, India.

Lactating adenoma is an uncommon palpable breast lesion occurring in the late pregnancy or lactation period and is commonly found in young primiparous women in the second or third decade of life. Although a benign condition, sometimes, core biopsy is required to exclude malignancy. Approximately 3% of all breast cancers occur in women who are pregnant; and hence, a breast mass in this group of women must be investigated. Read More

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http://dx.doi.org/10.4103/JMU.JMU_3_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6905250PMC

Recurrent giant fibroadenomas with transformation to cystosarcoma phyllodes in a 17-year-old girl: a rare case report from Syria.

J Med Case Rep 2019 Dec 21;13(1):378. Epub 2019 Dec 21.

Department of Pathology, Faculty of Medicine, Tishreen University, Lattakia, Syria.

Background: Fibroadenoma is the most prevalent benign breast lesion that generally affects middle-aged women; it is rare in adolescents and younger children. The transformation into malignancy is not common. However, multiple recurrences of rapidly enlarging fibroadenomas suggest a high possibility of transforming into phyllodes tumors, which are uncommon fibroepithelial lesions that account for 0. Read More

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http://dx.doi.org/10.1186/s13256-019-2313-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6925471PMC
December 2019

Expression of matrix metalloproteinase 2 and 9 in breast cancer and breast fibroadenoma: a randomized, double-blind study.

Oncotarget 2019 Dec 3;10(64):6879-6884. Epub 2019 Dec 3.

Postgraduate Program, Northeast Biotechnology Network (RENORBIO), Biotechnology in Health, Federal University of Piaui, Teresina, Piaui 64000-020, Brazil.

Background: Matrix metalloproteinases (MMPs) 2 and 9 may play an important role in cell proliferation and dissemination of cancer. However, few studies have compared the expression of these proteins between breast cancer and fibroadenoma.

Material And Methods: A randomized, double-blind study was carried out in 66 premenopausal women, aged 20-49 years, who had been diagnosed with fibroadenoma or breast cancer. Read More

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http://dx.doi.org/10.18632/oncotarget.27347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6901341PMC
December 2019

Imaging findings of ductal carcinoma in situ arising within fibroadenoma.

Breast J 2020 May 14;26(5):1037-1038. Epub 2019 Dec 14.

Department of Radiology, Yi Yang Central Hospital, Yiyang, China.

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http://dx.doi.org/10.1111/tbj.13709DOI Listing

EFEMP2 Inhibits Breast Cancer Invasion And Metastasis In Vitro And In Vivo.

Onco Targets Ther 2019 30;12:8915-8933. Epub 2019 Oct 30.

Department of Breast and Thyroid Surgery, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan 250013, People's Republic of China.

Background: EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) is an extracellular matrix (ECM) glycoprotein, which is regarded as potential prognostic biomarkers in some carcinoma. Little is known about the association of EFEMP2 and breast cancer.

Methods: EFEMP2 expressions in normal breast tissue, benign fibroadenoma, breast cancer, the normal mammary epithelial cell line, and 4 different invasive breast cancer cell lines were evaluated by immunohistochemistry (IHC) or immunocytochemistry (ICC) and real time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR). Read More

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http://dx.doi.org/10.2147/OTT.S221219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826198PMC
October 2019

Solitary Bone Cyst Like Areas in Myositis Ossificans: A Breast Mass in a Child.

Fetal Pediatr Pathol 2019 Nov 22:1-9. Epub 2019 Nov 22.

Radiology, Malatya Training and Research Hospital, Malatya, Turkey.

Myositis ossificans is an extraosseous, benign tumor-like condition characterized by prominent heterotopic ossification. Cystic degeneration in myositis ossificans is an uncommon entity. A 13-year-old girl presented with a large and painful breast lump. Read More

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http://dx.doi.org/10.1080/15513815.2019.1693673DOI Listing
November 2019

Magnetic resonance imaging of fibroadenoma-like lesions and correlation with Breast Imaging-Reporting and Data System and Kaiser scoring system.

SA J Radiol 2018 7;22(2):1532. Epub 2018 Nov 7.

Dr George Mukhari Academic Hospital, Ga-Rankuwa, South Africa.

Background: Multiple breast lesions resembling fibroadenomas are a common imaging finding in patients presenting to the mammography unit at Dr George Mukhari Academic Hospital in the North-West district of Tshwane, South Africa. Patients often present with multiple lesions, up to 20 lesions per breast. These lesions often have atypical features on ultrasound and/or a clinical history of growth is commonly given. Read More

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http://dx.doi.org/10.4102/sajr.v22i2.1532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837785PMC
November 2018

The Utility of Texture Analysis Based on Breast Magnetic Resonance Imaging in Differentiating Phyllodes Tumors From Fibroadenomas.

Front Oncol 2019 15;9:1021. Epub 2019 Oct 15.

Department of Radiology, Guangdong Women and Children Hospital, Guangzhou, China.

The preoperative diagnosis of phyllodes tumors (PTs) of the breast is critical to appropriate surgical treatment. However, reliable differentiation between PT and fibroadenoma (FA) remains difficult in daily clinical practice. The purpose of this study was to investigate the utility of breast MRI texture analysis for differentiating PTs from FAs. Read More

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http://dx.doi.org/10.3389/fonc.2019.01021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6803552PMC
October 2019

[Assessment of the cytokine-producing resource of tumor biopsy samples from patients with invasive carcinoma of no special type and with non-malignant breast diseases].

Biomed Khim 2019 Aug;65(5):418-423

Institute of Molecular Biology and Biophysics, Novosibirsk, Russia.

Breast cancer, in most cases, is a malignant neoplasm associated with infiltration of a tumor with the cells that form its microenvironment and produce various cytokines. The aim of the study was to evaluate the cytokine-producing function of tumor cells and their microenvironment in biopsy specimen of patients with invasive carcinoma of no special type and in patients with benign breast diseases. To assess the cytokine-producing activity of the tumor and its microenvironment, the index of polyclonal activators influence on cytokine production by biopsy specimens of patients with invasive carcinoma of no special type (group I) and in patients with benign breast tumors (group II) was calculated. Read More

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http://dx.doi.org/10.18097/PBMC20196505418DOI Listing

miR-188-5p suppresses cellular proliferation and migration via IL6ST: A potential noninvasive diagnostic biomarker for breast cancer.

J Cell Physiol 2020 May 24;235(5):4890-4901. Epub 2019 Oct 24.

Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China.

Previously, serum miR-188-5p is differentially expressed in breast cancer, but the diagnostic potential of circulating miR-188-5p as well as its regulatory mechanism in breast cancer remain uncertain. Herein, serum miR-188-5p was detected by real-time polymerase chain reaction in patients with breast cancer, breast fibroadenoma, and healthy subjects. Circulating miR-188-5p was abnormally elevated in patients with breast cancer as compared with these other two groups, and was reduced in patients with breast cancer following surgical treatment. Read More

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http://dx.doi.org/10.1002/jcp.29367DOI Listing

A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions.

BMC Med Genomics 2019 10 23;12(1):142. Epub 2019 Oct 23.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

Background: Known collectively as breast fibroepithelial lesions (FELs), the common fibroadenomas (FAs) and the rarer phyllodes tumors (PTs) are a heterogenous group of biphasic neoplasms. Owing to limited tissue availability, inter-observer variability, overlapping histological features and heterogeneity of these lesions, diagnosing them accurately on core biopsies is challenging. As the choice management option depends on the histological diagnosis; a novel 16-gene panel assay was developed to improve the accuracy of preoperative diagnosis on core biopsy specimens. Read More

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http://dx.doi.org/10.1186/s12920-019-0588-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813086PMC
October 2019
2.873 Impact Factor

Adding bit of esthetics with science modification of batwing mastopexy for breast conservation in a young patient with giant fibroadenoma breast.

J Cancer Res Ther 2019 Jul-Sep;15(5):1173-1176

Department of Surgical Oncology, St. John's Medical College, Bengaluru, Karnataka, India.

A 19-year-old girl presented with a lump in her right breast and with a history of surgery for the similar complaint 3 years back. Ultrasound was suggestive of benign solitary lesion of size 16 cm × 10 cm. Core biopsy was suggestive of phyllodes tumor, and the histopathology report of previous surgery was also suggestive of phyllodes tumor. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_818_17DOI Listing
October 2019
2 Reads

Symptomatic Fibroadenoma Resolves Status Post Cryoablation.

R I Med J (2013) 2019 Oct 1;102(8):49-52. Epub 2019 Oct 1.

Rhode Island Hospital, Department of Diagnostic Imaging, Providence, RI.

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October 2019