468,867 results match your criteria Breast Edinburgh Scotland[Journal]


[Clinical characteristic of 74 cases of malignant tumor in rheumatoid arthritis].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Dec;50(6):986-990

Department of Rheumatology and Immunology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Objective: To investigate the clinical characteristics of rheumatoid arthritis (RA) patients with malignant tumor.

Methods: Retrospective summary was made of 1 562 in patients of RA from January 2011 to June 2017. In the study, 74 RA patients with malignant tumor were reviewed and analyzed, and the general conditions, tumor types, RA and tumor onset sequence, and the medication situation were analyzed. Read More

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December 2018

ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion.

Cell Physiol Biochem 2018 Dec 14;51(6):2972-2988. Epub 2018 Dec 14.

Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, Chongqing,

Background/aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor. Although evidence shows that a DNA damage-independent ATM (oxidized ATM) may be involved in cancer progression, the underlying mechanism is still unclear.

Methods: Immunohistochemistry, immunofluorescence and western blotting were applied to detect the levels of oxidized ATM. Read More

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http://dx.doi.org/10.1159/000496048DOI Listing
December 2018

Effects of Platycodin D on S100A8/A9-induced inflammatory response in murine mammary carcinoma 4T1 cells.

Int Immunopharmacol 2018 Dec 15;67:239-247. Epub 2018 Dec 15.

Institute of Chinese Traditional Surgery, LongHua Hospital Shanghai University of Traditional Chinese Medicine, 725 Wanpingnan Road, Shanghai 200032, China; Department of Breast Surgery, LongHua Hospital Shanghai University of Traditional Chinese Medicine, 725 Wanpingnan Road, Shanghai 200032, China. Electronic address:

Activation of the inflammatory signaling pathway is the most vital part of the pre-metastatic events of breast cancer. Platycodin D (PlaD) shows favorable pharmacological activities in anti-inflammatory and anti-tumor effect. The main purpose of this study was to survey the effects of PlaD on S100A8/A9-induced inflammation in mouse mammary carcinoma 4T1 cells. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.12.008DOI Listing
December 2018

Breast cancer detection using targeted plasma metabolomics.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Dec 3;1105:26-37. Epub 2018 Dec 3.

Arizona Metabolomics Laboratory, College of Health Solutions, Arizona State University, Scottsdale, AZ 85259, USA. Electronic address:

Breast cancer (BC) is a major cause of human morbidity and mortality, especially among women. Despite the important role of metabolism in the molecular pathogenesis of cancer, robust metabolic markers to enable enhanced screening and disease monitoring of BC are still critically needed. In this study, a targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) metabolic profiling approach is presented for the identification of metabolic marker candidates that could enable highly sensitive and specific detection of all-stage as well as early-stage BC. Read More

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http://dx.doi.org/10.1016/j.jchromb.2018.11.029DOI Listing
December 2018

Differential effects of protein kinase C-eta on apoptosis versus senescence.

Cell Signal 2018 Dec 15. Epub 2018 Dec 15.

Department of Microbiology, Immunology & Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA.

Protein kinase C-eta (PKCη) is considered an anti-apoptotic kinase, which promotes cell survival and chemoresistance in several cancers, including breast cancer. We have recently shown that PKCη positively regulates the anti-apoptotic protein Mcl-1 in breast cancer cells, and depletion of PKCη induced proteasomal degradation of Mcl-1. We therefore examined if depletion of PKCη would enhance cellular sensitivity to chemotherapeutic agents. Read More

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http://dx.doi.org/10.1016/j.cellsig.2018.12.003DOI Listing
December 2018

CD44 Orchestrates Metastatic Teamwork.

Dev Cell 2018 Dec;47(6):691-693

INSERM UMR_S1109, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg, France. Electronic address:

Inhibition of metastatic cancer cell colonization and outgrowth is arguably one of the greatest therapeutic challenges. Reporting in Cancer Discovery, Liu et al. (2018) describe how homophilic interactions of CD44, a classical breast cancer stem cell marker, drive tumor cell aggregation outside the primary tumor to augment their metastatic potential. Read More

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http://dx.doi.org/10.1016/j.devcel.2018.11.038DOI Listing
December 2018

A cost-effectiveness analysis of DIEP vs free MS-TRAM flap for microsurgical breast reconstruction.

J Surg Oncol 2018 Dec 18. Epub 2018 Dec 18.

Division of Plastic and Reconstructive Surgery, University Health Network, Toronto, Ontario, Canada.

Background And Objectives: The deep inferior epigastric perforator (DIEP) flap may be associated with less long-term donor-site morbidity compared with free muscle-sparing transverse rectus abdominis myocutaneous flap (MS-TRAM) flap. However, DIEP flaps may have longer operative time and higher rates of acute postoperative complications. We performed a cost-effectiveness analysis (CEA) that compared the long-term costs and patient-reported outcomes between the two flaps. Read More

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http://dx.doi.org/10.1002/jso.25325DOI Listing
December 2018

Vaginal estrogen use and chronic disease risk in the Nurses' Health Study.

Menopause 2018 Dec 17. Epub 2018 Dec 17.

Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Objective: To examine the associations between vaginal estrogen use and multiple health outcomes including cardiovascular disease (total myocardial infarction, stroke, and pulmonary embolism/deep vein thrombosis), cancer (total invasive, breast, endometrial, ovarian, and colorectal cancer), and hip fracture.

Methods: We included postmenopausal women from the Nurses' Health Study (1982-2012) who were not current users of systemic hormone therapy at the start of the study or during follow-up. Vaginal estrogen use was self-reported on the biennial questionnaires. Read More

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http://dx.doi.org/10.1097/GME.0000000000001284DOI Listing
December 2018

Changes in Unilateral Upper Limb Muscular Strength and Electromyographic Activity After a 16-Week Strength Training Intervention in Survivors of Breast Cancer.

J Strength Cond Res 2019 Jan;33(1):225-233

School of Science and Health, Department of Sport and Exercise Science Western Sydney University, Campbelltown, Australia.

Hagstrom, AD, Shorter, KA, and Marshall, PWM. Changes in unilateral upper limb muscular strength and Electroymographic activity after a 16-week strength training intervention in survivors of breast cancer. J Strength Cond Res 33(1): 225-233, 2019-Upper limb strength deficits are frequently observed following breast cancer (BC) and its treatments. Read More

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http://dx.doi.org/10.1519/JSC.0000000000001890DOI Listing
January 2019

Dedifferentiated Melanoma With Expression of Cytokeratin and GATA3 in a Patient With History of Breast Carcinoma.

Am J Dermatopathol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pathology, UPMC Shadyside, Pittsburgh, PA.

Melanoma is one of the great mimickers in pathology because it has diverse morphologies and can be mistaken for carcinoma or sarcoma. In most cases, immunochemistry is helpful in supporting the diagnosis and excluding other differentials. However, metastatic melanoma may lose immunohistochemical melanocytic markers and express nonmelanocytic lineage markers, which often poses a diagnostic dilemma and may be misdiagnosed as a poorly differentiated carcinoma or sarcoma. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001322DOI Listing
December 2018

Y-Peg-in-a-Round-Hole Closure for Immediate Periareolar Mastectomy Expander Reconstruction.

Ann Plast Surg 2018 Dec 18. Epub 2018 Dec 18.

Department of Plastic Surgery, St Vincent's Hospital, Melbourne.

Introduction: Mastectomies closed with a linear scar can distort the resulting shape of the breast. We present our novel Y-peg-in-a-round-hole closure method of the mastectomy scar, which improves the shape of the reconstructed breast while maintaining reliable healing, implant coverage, and minimum scar size for covering by tattoo.

Materials And Methods: A retrospective review of all breast reconstruction cases performed by the senior surgeon during the period from January 2010 to January 2017 was undertaken. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001690DOI Listing
December 2018

Muscle-Splitting Augmentation-Mastopexy: Implant Protection With an Inferior Dermoglandular Flap.

Ann Plast Surg 2018 Dec 18. Epub 2018 Dec 18.

Hospital Moinhos de Vento, Porto Alegre, Rio Grande do Sul, Brazil.

Simultaneous augmentation-mastopexy can achieve excellent patient and surgeon satisfaction but continues to pose a challenge, with revision rates of up to 25%. Recurrent ptosis and poor overall breast shape are 2 common reasons for reoperation, whereas some of the most feared complications is breast implant exposure, infection, and loss secondary to wound breakdown; excessively large implants or too much tension during closure are possible contributing factors. We describe a technique for augmentation-mastopexy combining a muscle-splitting pocket for implant placement along with an inferior flap, which helps secure the implant in place and provides coverage in case of wound dehiscence. Read More

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http://dx.doi.org/10.1097/SAP.0000000000001689DOI Listing
December 2018

Incidental Detection of Plasma Cell Neoplasm on 18F-Choline PET/CT Imaging.

Clin Nucl Med 2018 Dec 17. Epub 2018 Dec 17.

From the Departments of Nuclear Medicine, and.

F-Fluorocholine is a relatively new, extremely versatile radiotracer for detecting proliferative or mitogenic activity. Its diagnostic potential has been explored in cancers of the prostate, liver, esophagus, breast, brain, and lung, as well as lymphoma, sarcoma, melanoma, and parathyroid adenomas. The authors present a case where fluorocholine PET/CT performed for characterizing a space-occupying lesion in the brain revealed intensely tracer-avid skull lesions with intracranial soft tissue component and multiple other skeletal lesions. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002415DOI Listing
December 2018

Optimizing Patient Positioning to Reduce Variation in the Measurement of Breast Cancer-Related Lymphedema.

Lymphat Res Biol 2018 Dec 18. Epub 2018 Dec 18.

4 Department of Radiation Oncology, and The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Prospective lymphedema screening is recommended for breast cancer patients. We observed interoperator variation in perometer-acquired arm volume measurements (P-AVMs) due to patient instability during measurements. We hypothesized that improved positioning during perometry would reduce P-AVM variability. Read More

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http://dx.doi.org/10.1089/lrb.2018.0018DOI Listing
December 2018

Development and Evaluation of a New In Vivo Volume Measuring System in Mouse Tail Lymphedema Model.

Lymphat Res Biol 2018 Dec 18. Epub 2018 Dec 18.

1 Biorobotics Laboratory, Department of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Republic of Korea.

Backgrounds: Secondary lymphedema is a common complication of parasitization and breast or gynecologic cancer therapy; however, options for the treatment of lymphedema are ineffective and limited. A mouse tail model is one of the most successful animal models for a lymphatic study. Lymphedema of the mouse tail is characterized by increases in the volume of the extremity caused by accumulation of tissue fluid, proliferation of fibroblasts and adipocytes, and excessive production of collagen. Read More

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http://dx.doi.org/10.1089/lrb.2018.0019DOI Listing
December 2018

Using the Healthy Days Measure to Assess Factors Associated with Poor Health-Related Quality of Life for Patients with Metastatic Breast, Lung, or Colorectal Cancer Enrolled in a Medicare Advantage Health Plan.

Popul Health Manag 2018 Dec 18. Epub 2018 Dec 18.

2 Genentech, Inc., South San Francisco, California.

This study investigated factors associated with patient-reported health-related quality of life (HRQoL) using the Centers for Disease Control and Prevention's Healthy Days tool for patients with Medicare Advantage undergoing treatment for metastatic breast, lung, and colorectal cancer. In 2015, a total of 6390 patients were mailed surveys regarding factors that may influence their HRQoL, including cancer-related symptoms and patient-reported medication adherence. HRQoL was measured as the number of physically and mentally unhealthy days experienced in the past 30 days and summed for the total number of unhealthy days. Read More

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http://dx.doi.org/10.1089/pop.2018.0024DOI Listing
December 2018

Bone Mineral Density and Breast Cancer Incidence and Mortality in Postmenopausal Women: A Long-Term Follow-Up Study.

J Womens Health (Larchmt) 2018 Dec 18. Epub 2018 Dec 18.

1 Agency for Preventive and Social Medicine, Bregenz, Austria.

Purpose: To examine whether bone mineral density (BMD) is predictive of breast cancer risk and mortality in a population of early postmenopausal women participating in a medical prevention program in western Austria.

Patients And Methods: Between May 1991 and February 1999, lumbar spine BMD was measured by dual-energy X-ray absorptiometry (N = 1163, mean age 56.9 ± 5. Read More

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http://dx.doi.org/10.1089/jwh.2018.7310DOI Listing
December 2018

Overview of perimenopausal contraception.

Authors:
J Bitzer

Climacteric 2018 Dec 18:1-7. Epub 2018 Dec 18.

a Frauenklinik , Universitätsspital Basel , Basel , Switzerland.

The perimenopause is accompanied by important biological and psychosocial changes. The choice of contraceptive methods for women in the perimenopause, none of which is limited by age alone, will depend on the efficacy, safety, tolerability, and potential benefit of each method in relation to the biopsychosocial profile of the individual woman. Copper intrauterine devices are highly effective in the typical user and are a very safe method with, in general, good tolerability but are of limited use in women with heavy menstrual bleeding and subserous myomata. Read More

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http://dx.doi.org/10.1080/13697137.2018.1540566DOI Listing
December 2018

Testing a biobehavioral model of fatigue before adjuvant therapy in women with breast cancer.

Cancer 2018 Dec 18. Epub 2018 Dec 18.

Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, California.

Background: Fatigue is one of the most common and disabling side effects of cancer and its treatment. Although research typically has focused on fatigue that occurs during and after treatment, patients may experience fatigue even before treatment onset. The current study was designed to identify biobehavioral risk factors associated with fatigue before adjuvant therapy in women with early-stage breast cancer. Read More

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http://dx.doi.org/10.1002/cncr.31827DOI Listing
December 2018

Association of Medicaid enrollee characteristics and primary care utilization with cancer outcomes for the period spanning Medicaid expansion in New Jersey.

Cancer 2018 Dec 18. Epub 2018 Dec 18.

Center for State Health Policy, Rutgers, the State University of New Jersey, New Brunswick, New Jersey.

Background: Cancer outcomes for Medicaid enrollees may be affected by patients' primary care (PC) utilization and complex Medicaid enrollment dynamics, which have recently changed for many states under the Affordable Care Act.

Methods: With New Jersey State Cancer Registry and linked Medicaid claims data, a retrospective cohort study was conducted for patients with incident breast, colorectal, or invasive cervical cancer (aged 21-64 years) diagnosed in 2012-2014. Associations of Medicaid enrollment factors and PC utilization with the stage at diagnosis and treatment delays were examined with multivariate logistic regression models. Read More

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http://dx.doi.org/10.1002/cncr.31824DOI Listing
December 2018

The relationship between terminal duct lobular unit features and mammographic density among Chinese breast cancer patients.

Int J Cancer 2018 Dec 18. Epub 2018 Dec 18.

Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Extensive mammographic density (MD), a well-established breast cancer risk factor, is a radiological representation of stromal and epithelial breast tissue content. In studies conducted predominantly among Caucasian women, histologic measures of reduced terminal duct lobular unit (TDLU) involution have been correlated with extensive MD, but independently associated with breast cancer risk. We therefore examined associations between TDLU measures and MD among Chinese women, a low-risk population but with high prevalence of dense breasts. Read More

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http://dx.doi.org/10.1002/ijc.32077DOI Listing
December 2018

Discussions about contralateral prophylactic mastectomy among surgical oncology providers and women with sporadic breast cancer: a content analysis.

Transl Behav Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Rates of contralateral prophylactic mastectomy (CPM) have risen substantially, yet little is known about how and to what extent CPM is discussed within surgical oncology visits at the time of treatment decision-making. We examined CPM discussions in naturally occurring interactions between sporadic breast cancer patients and their surgical oncology providers. Women with early-stage unilateral disease were recruited before their first surgical visit and completed brief questionnaires to determine study eligibility and interest in treatment options. Read More

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http://dx.doi.org/10.1093/tbm/iby098DOI Listing
December 2018

Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology.

J Natl Cancer Inst 2018 Dec 17. Epub 2018 Dec 17.

Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins, Baltimore, MD.

Traditionally, drug development has evaluated dose, safety, activity, and comparative benefit in a sequence of phases using trial designs and endpoints specifically devised for each phase. Innovations in drug development seek to consolidate the phases and rapidly expand accrual with "seamless" trial designs. Although consolidation and rapid accrual may yield efficiencies, widespread use of seamless first-in-human (FiH) trials without careful consideration of objectives, statistical analysis plans, or trial oversight raises concerns. Read More

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http://dx.doi.org/10.1093/jnci/djy196DOI Listing
December 2018

BRCA1/2 gene mutations do not affect the capacity of oocytes from breast cancer candidates for fertility preservation to mature in vitro.

Hum Reprod 2018 Dec 17. Epub 2018 Dec 17.

Department of Reproductive Medicine and Fertility Preservation, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France.

Study Question: Are the maturation rates of oocytes recovered from small antral follicles different between breast cancer patients presenting with or without a BRCA 1/2 gene mutation?

Summary Answer: BRCA 1/2 gene mutations do not affect the capacity of oocytes from breast cancer candidates for fertility preservation to mature in vitro.

What Is Known Already: Mutations in the BRCA1 and BRCA2 genes are associated with an increased risk for developing breast and ovarian cancer. Controversy exists about fertility and ovarian reserve in BRCA mutation carriers. Read More

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http://dx.doi.org/10.1093/humrep/dey358DOI Listing
December 2018

Exploring drivers of gene expression in the Cancer Genome Atlas.

Bioinformatics 2019 Jan;35(1):62-68

Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.

Motivation: The Cancer Genome Atlas (TCGA) has greatly advanced cancer research by generating, curating and publicly releasing deeply measured molecular data from thousands of tumor samples. In particular, gene expression measures, both within and across cancer types, have been used to determine the genes and proteins that are active in tumor cells.

Results: To more thoroughly investigate the behavior of gene expression in TCGA tumor samples, we introduce a statistical framework for partitioning the variation in gene expression due to a variety of molecular variables including somatic mutations, transcription factors (TFs), microRNAs, copy number alternations, methylation and germ-line genetic variation. Read More

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http://dx.doi.org/10.1093/bioinformatics/bty551DOI Listing
January 2019

Commentary on: Identification of the Optimal Recipient Layer for Transplanted Fat: A Prospective Study on Breast Lipoaugmentation.

Authors:
Kamran Khoobehi

Aesthet Surg J 2018 Dec 17. Epub 2018 Dec 17.

Clinical Associate Professor of Surgery and Director of Aesthetic Surgery Training, Section of Plastic and Reconstructive Surgery, Louisiana State University New Orleans, New Orleans, LA.

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http://dx.doi.org/10.1093/asj/sjy312DOI Listing
December 2018

Evaluating Patient Outcomes in Breast and Abdominal Cosmetic Plastic Surgery Procedures Involving Residents.

Aesthet Surg J 2018 Dec 18. Epub 2018 Dec 18.

Institute for Reconstructive Surgery, Houston Methodist Hospital, Weill Cornell Medicine, Houston, TX.

Background: Hands-on training and exposure to cosmetic surgery is an integral part of plastic surgery residency. However, resident participation in cosmetic surgical cases is often times limited in many training programs. Furthermore, the effect of resident participation in cosmetic surgery is poorly defined. Read More

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http://dx.doi.org/10.1093/asj/sjy329DOI Listing
December 2018

Cutaneous granular cell tumor clinically mimicking ectopic breast diagnosed on fine needle aspiration cytology.

Diagn Cytopathol 2018 Dec 18. Epub 2018 Dec 18.

Department of Pathology and Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Granular cell tumor (GCT) is a rare benign neoplasm of Schwannian origin which accounts of 0.5% of soft tissue tumors. Although the most common site for GCT is tongue, it can occur at any site. Read More

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http://dx.doi.org/10.1002/dc.24124DOI Listing
December 2018

Effect of storage temperatures and duration on quality of prepared chicken breast with paprika oleoresin.

Anim Sci J 2018 Dec 18. Epub 2018 Dec 18.

Nanjing Innovation Center of Meat Products Processing, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, China.

The objective of this study was to investigate the effect of storage temperatures and time on discoloration and oxidation of prepared chicken breast with paprika oleoresin. Freshly prepared chicken breast containing paprika oleoresin was stored at -2, -10, -18°C, and an oscillating temperature between -10 and -18°C (-10/-18°C). A significant decrease in redness was detected at -2, -10, and -10/-18°C. Read More

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http://dx.doi.org/10.1111/asj.13117DOI Listing
December 2018

Impact of pretreatments on outcomes after living donor liver transplantation for hepatocellular carcinoma.

J Hepatobiliary Pancreat Sci 2018 Dec 18. Epub 2018 Dec 18.

Department of Hepatobiliary Pancreatic Surgery and Transplantation, Kyoto University, 54 Shogoin Kawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: The purpose of this study was to examine the impact of pretreatments on outcomes after living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC).

Methods: From February 1999 to March 2015, 223 patients underwent LDLT for HCC. Until December 2006, there was no restriction in patient selection criteria regarding the number and size of tumors, following which we implemented the Kyoto criteria (tumor number ≤10, maximal diameter ≤5 cm, and des-gamma-carboxy prothrombin ≤400 mAU/mL) since January 2007. Read More

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http://dx.doi.org/10.1002/jhbp.602DOI Listing
December 2018

Effect of chemotherapy and aromatase inhibitors in the adjuvant treatment of breast cancer on glucose and insulin metabolism-A systematic review.

Cancer Med 2018 Dec 18. Epub 2018 Dec 18.

Diabetes and Bone-Metabolic Research Unit, Department of Endocrinology, Rigshospitalet, København Ø, Denmark.

Introduction: Breast cancer (BC) is the most common cancer among women worldwide. With increasing survival rates, focus has expanded to long-term adverse effects of adjuvant chemotherapy and/or aromatase inhibitors. Weight gain during chemotherapy has been well documented, but the underlying mechanisms remain unclear. Read More

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http://dx.doi.org/10.1002/cam4.1911DOI Listing
December 2018

Can a Channelized Hotelling Observer assess image quality in acquired mammographic images of an anthropomorphic breast phantom including image processing?

Med Phys 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, Leiden University Medical Centre, Albinusdreef 2, 2333 ZA, Leiden, Netherlands.

Purpose: To study the feasibility of a channelized Hotelling observer (CHO) to predict human observer performance in detecting calcification-like signals in mammography images of an anthropomorphic breast phantom, as part of a quality control (QC) framework.

Methods: A prototype anthropomorphic breast phantom with inserted gold discs of 0.25 mm diameter was imaged with two different digital mammography x-ray systems at four different dose levels. Read More

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http://dx.doi.org/10.1002/mp.13342DOI Listing
December 2018

Is pectus excavatum a risk factor for radiation-induced lung disease in patients undergoing radiation therapy following breast-conserving surgery?

Thorac Cancer 2018 Dec 18. Epub 2018 Dec 18.

Department of Radiology, Nihon University School of Medicine, Tokyo, Japan.

Background: The relationship between radiation dose to the ipsilateral lung and subsequent radiation-induced lung disease (RILD) in breast cancer patients with pectus excavatum (PE) undergoing radiation therapy (RT) to residual breast tissue after breast-conserving surgery has not yet been established. The incidence of RILD in such patients with PE, meaning that a large volume of the lung is within the radiation field, has not been determined. Therefore, the aim of this study was to determine the relationship between these factors. Read More

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http://dx.doi.org/10.1111/1759-7714.12933DOI Listing
December 2018

Mid-region parathyroid hormone-related protein is a genome-wide chromatin-binding factor that promotes growth and differentiation of HB2 epithelial cells from the human breast.

Biofactors 2018 Dec 18. Epub 2018 Dec 18.

Dipartimento di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università di Palermo, Palermo, Italy.

Human parathyroid hormone-related protein (PTHrP) is a polyhormone that undergoes proteolytic cleavage producing smaller peptides which exert diversified biological effects. PTHrP signalization is prominently involved in breast development and physiology, but the studies have been focused onto either N-terminal species or full-length protein introduced by gene transfer techniques. Our present work investigates for the first time the effect of the mid-region PTHrP secretory form, that is, the fragment [38-94], on HB2 non-tumoral breast epithelial cells. Read More

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http://dx.doi.org/10.1002/biof.1484DOI Listing
December 2018

Occurrence of Heterocyclic Amines in Commercial Fast-Food Meat Products Available on the Chinese Market and Assessment of Human Exposure to these Compounds.

J Food Sci 2018 Dec 18. Epub 2018 Dec 18.

Nanjing Innovation Center of Meat Products Processing, Synergetic Innovation Center of Food Safety and Nutrition, and College of Food Science and Technology, Nanjing Agricultural Univ., Nanjing, Jiangsu, 210095, PR China.

Heterocyclic amines (HCAs) have been identified as highly mutagenic and are risk factors for human cancer. In recent years, the intake of fast-food meat products has increased exponentially due to their convenience. Therefore, it is important to assess the health risks of HCAs and provide useful public dietary guidelines. Read More

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http://dx.doi.org/10.1111/1750-3841.14418DOI Listing
December 2018

Pre-diagnostic derivatives of reactive oxygen metabolites and the occurrence of lung, colorectal, breast and prostate cancer: An individual participant data meta-analysis of two large population-based studies.

Int J Cancer 2018 Dec 18. Epub 2018 Dec 18.

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.

Oxidative stress may be involved in carcinogenesis and biomarkers of oxidative stress like derivatives of reactive oxygen metabolites (d-ROM) may be useful for cancer prediction. However, no previous study assessed the association of pre-diagnostic d-ROM measurements with cancer incidence. We measured d-ROM in a cohort sample of n = 4,345 participants of the German ESTHER study and in a case-cohort sample of the Norwegian Tromsø study (cancer cases: n = 941; sub-cohort: n = 1,000). Read More

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http://dx.doi.org/10.1002/ijc.32073DOI Listing
December 2018

High-resolution deconstruction of evolution induced by chemotherapy treatments in breast cancer xenografts.

Sci Rep 2018 Dec 18;8(1):17937. Epub 2018 Dec 18.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06030, USA.

The processes by which tumors evolve are essential to the efficacy of treatment, but quantitative understanding of intratumoral dynamics has been limited. Although intratumoral heterogeneity is common, quantification of evolution is difficult from clinical samples because treatment replicates cannot be performed and because matched serial samples are infrequently available. To circumvent these problems we derived and assayed large sets of human triple-negative breast cancer xenografts and cell cultures from two patients, including 86 xenografts from cyclophosphamide, doxorubicin, cisplatin, docetaxel, or vehicle treatment cohorts as well as 45 related cell cultures. Read More

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http://dx.doi.org/10.1038/s41598-018-36184-8DOI Listing
December 2018

A 3D microvascular network model to study the impact of hypoxia on the extravasation potential of breast cell lines.

Sci Rep 2018 Dec 18;8(1):17949. Epub 2018 Dec 18.

BioSystems and Micromechanics, IRG, Singapore-MIT Alliance for Research and Technology, Singapore, 138602, Singapore.

Hypoxia is a common feature of the tumor microenvironment. Accumulating evidence has demonstrated hypoxia to be an important trigger of tumor cell invasion or metastasizes via hypoxia-signaling cascades, including hypoxia-inducible factors (HIFs). Microfluidic model can be a reliable in vitro tool for systematically interrogating individual factors and their accompanying downstream effects, which may otherwise be difficult to study in complex tumor tissues. Read More

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http://dx.doi.org/10.1038/s41598-018-36381-5DOI Listing
December 2018

Effects of dietary habits and sedentary lifestyle on breast cancer among women attending the oncology day treatment center at a state university in Turkey.

Authors:
H Toklu N H Nogay

Niger J Clin Pract 2018 Dec;21(12):1576-1584

Department of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, Kayseri, Turkey.

Background: Certain lifestyle factors affect the risk of developing breast cancer. Especially, diet and physical activity play a primary role in preventing breast cancer. However, the results of studies on this subject in different societies are still conflicting. Read More

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http://dx.doi.org/10.4103/njcp.njcp_238_18DOI Listing
December 2018

Optimizing PCR Detection of Zika Virus from Various Body Fluids.

Am J Trop Med Hyg 2018 Dec 17. Epub 2018 Dec 17.

Department of Pediatrics-Tropical Medicine, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.

Current diagnostic protocols of acute Zika virus (ZIKV) infection focus on detection of viral RNA in serum or urine using RT-qPCR; however, detecting infection can be a challenge, given that 80% of people with acute ZIKV infection are asymptomatic, and the window to detect viremia in serum is short. The ability to extend that window is needed to detect ZIKV at later time points after infection, particularly in high-risk individuals such as pregnant women. We evaluated RNA extraction methods to optimize detection of ZIKV in various body fluids using RT-qPCR as a means of improving the analytical sensitivity of detection. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0755DOI Listing
December 2018

KLP-PI: a new prognostic index for luminal B HER-2-negative breast cancer.

Hum Cell 2018 Dec 17. Epub 2018 Dec 17.

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbai Xiang Street, Wenzhou, 325000, Zhejiang, People's Republic of China.

Luminal B HER-2-negative (LBHN) subtype is one of the major subtypes of breast cancer according to different features, clinical behaviors, and treatment response. The LBHN subtype shows a poor prognosis and is insensitive to endocrine therapy. Our work aim is to investigate the prognostic factor in the LBHN subgroup and, meanwhile, try to obtain an optimal prognostic index (PI) contrapose LBHN subgroup which helps to guide chemotherapy. Read More

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http://dx.doi.org/10.1007/s13577-018-00229-xDOI Listing
December 2018

Changes in total choline concentration in the breast of healthy fertile young women in relation to menstrual cycle or use of oral contraceptives: a 3-T H-MRS study.

Eur Radiol Exp 2018 Dec 17;2(1):43. Epub 2018 Dec 17.

Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Rome, Italy.

Background: To evaluate changes in total choline (tCho) absolute concentration ([tCho]) in the breast of healthy fertile women in relation to menstrual cycle (MC) or use of oral contraceptives (OC).

Methods: After institutional review board approval, we prospectively evaluated 40 healthy fertile volunteers: 20 with physiological MC, aged 28 ± 3 years (mean ± standard deviation; nOC group); 20 using OC, aged 26 ± 3 years (OC group). Hormonal assays and water-suppressed single-voxel 3-T proton magnetic resonance spectroscopy (H-MRS) were performed on MC days 7, 14, and 21 in the nOC group and only on MC day 14 in the OC group. Read More

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http://dx.doi.org/10.1186/s41747-018-0075-0DOI Listing
December 2018

Anti-Invasive and Anti-Proliferative Effects of shRNA-Loaded Poly(Lactide-Co-Glycolide) Nanoparticles Following RAN Silencing in MDA-MB231 Breast Cancer Cells.

Pharm Res 2018 Dec 17;36(2):26. Epub 2018 Dec 17.

Institute of Cancer Therapeutics, ICT building, University of Bradford, Richmond Road, Bradford, England, BD7 1DP, UK.

Background: Overexpression of the RAN GTP (RAN) gene has been shown to be linked to metastatic activity of MDA-MB231 human breast cancer cells by increasing Ras/MEK/ERK and PI3K/Akt/mTORC1 signalling. The aim of this study was to investigate the potential of polymeric nanoparticles to deliver two novel shRNA sequences, targeted against the RAN gene, to MDA-MB231 cells grown in culture and to assess their effects in a range of biological assays.

Methods: Biodegradable PLGA nanoparticles, loaded with shRNA-1 and shRNA-4, were fabricated using a double emulsion solvent evaporation technique and characterised for size, zeta potential and polydispersity index before testing on the MDA-MB231 cell line in a range of assays including cell viability, migration, invasion and gene knock down. Read More

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http://dx.doi.org/10.1007/s11095-018-2555-6DOI Listing
December 2018

Examination of a paradox: recurrent metastatic breast cancer incidence decline without improved distant disease survival: 1990-2011.

Breast Cancer Res Treat 2018 Dec 17. Epub 2018 Dec 17.

Swedish Cancer Institute, Seattle, WA, USA.

Purpose: Distant relapse metastatic breast cancer (rMBC) incidence and survival are vital measures of breast cancer diagnosis and treatment progress over time.

Methods: We conducted a retrospective cohort study of stage I-III invasive breast cancer, 1990-2011, follow-up through 2016 [N = 8292, rMBC = 964 (12%)] at a community-based institution. Patient and tumor characteristics (treatment, distant recurrence, vital status) from BC registry data were evaluated. Read More

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http://dx.doi.org/10.1007/s10549-018-05090-yDOI Listing
December 2018

The estrogen receptor-alpha S118P variant does not affect breast cancer incidence or response to endocrine therapies.

Breast Cancer Res Treat 2018 Dec 17. Epub 2018 Dec 17.

The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: Estrogen receptor-alpha (ER) is a therapeutic target of ER-positive (ER+) breast cancers. Although ER signaling is complex, many mediators of this pathway have been identified. Specifically, phosphorylation of ER at serine 118 affects responses to estrogen and therapeutic ligands and has been correlated with clinical outcomes in ER+ breast cancer patients. Read More

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http://dx.doi.org/10.1007/s10549-018-05087-7DOI Listing
December 2018

Prevalence of breast cancer-related risk factors in underweight premenopausal women: the Korea National Health and Nutrition Examination Survey IV-VI.

Breast Cancer Res Treat 2018 Dec 17. Epub 2018 Dec 17.

Division of Breast Surgery, Department of Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Purpose: This study aimed to examine the prevalence and trends of breast cancer-related risk factors and characteristics in premenopausal underweight Korean women according to birth year cohort.

Methods: Socioeconomic and breast cancer-related risk factors were investigated in 13,415 premenopausal women using nationwide cross-sectional surveys performed between 2007 and 2015. Underweight was defined as body mass index < 18. Read More

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http://dx.doi.org/10.1007/s10549-018-05091-xDOI Listing
December 2018

Oral bisphosphonates and incidence of cancers in patients with osteoporosis: a systematic review and meta-analysis.

Arch Osteoporos 2018 Dec 17;14(1). Epub 2018 Dec 17.

Department of Oncology, Affiliated Hospital of Qinghai University, No. 29 Tongren Road, Xining, 810000, China.

Purpose: Several previous studies have shown that oral bisphosphonates (BPs) are associated with the incidence of 13 specific cancers, including lung cancer, esophageal cancer, gastric cancer, and colorectal cancer (CRC). However, the findings are heterogeneous.

Methods And Results: Relevant studies published in databases such as PubMed, Embase database, and Cochrane library were systematically retrieved from inception to August 25th, 2018, regardless of language, by two investigators independently. Read More

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http://dx.doi.org/10.1007/s11657-018-0552-3DOI Listing
December 2018

Synthesis and Characterization of PLGA-PEG Thymoquinone Nanoparticles and Its Cytotoxicity Effects in Tamoxifen-Resistant Breast Cancer Cells.

Adv Exp Med Biol 2018 Dec 18. Epub 2018 Dec 18.

Oncological and Radiological Sciences Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Penang, Malaysia.

Introduction: Drug resistance has been a continuous challenge in cancer treatment. The use of nanotechnology in the development of new cancer drugs has potential. One of the extensively studied compounds is thymoquinone (TQ), and this work aims to compare two types of TQ-nanoformulation and its cytotoxicity toward resistant breast cancer cells. Read More

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http://dx.doi.org/10.1007/5584_2018_302DOI Listing
December 2018

Optimism outweighs neuroticism and anxiety sensitivity to predict insomnia symptoms in women after surgery for breast cancer.

Support Care Cancer 2018 Dec 17. Epub 2018 Dec 17.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.

Purpose: Insomnia symptoms are common among women who have undergone surgery for breast cancer. Personality traits are also believed to have an impact on sleep. However, there are no reports to address the effects of personality traits on sleep in women with breast cancer. Read More

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http://dx.doi.org/10.1007/s00520-018-4610-6DOI Listing
December 2018

Ovarian metastasis from breast cancer: a comprehensive review.

Clin Transl Oncol 2018 Dec 17. Epub 2018 Dec 17.

Department of Surgical Oncology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.

Breast is one of the most common primary origins of secondary ovarian cancer. There are some factors that influence the incidence of ovarian metastases (OM), such as histological type of primary cancer. OM from breast cancers are frequently asymptomatic until the masses have grown to certain size, and the metastatic tumors are frequently manifested as bilateral, solid, small ovarian masses. Read More

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http://dx.doi.org/10.1007/s12094-018-02007-5DOI Listing
December 2018