473,651 results match your criteria Breast Edinburgh Scotland[Journal]


Varied effects of dietary carotenoid supplementation on oxidative damage in tissues of two waterfowl species.

Comp Biochem Physiol B Biochem Mol Biol 2019 Feb 19. Epub 2019 Feb 19.

College of Health Solutions, Arizona State University, Phoenix, AZ, United States of America; School of Life Sciences, Arizona State University, Tempe, AZ, United States of America. Electronic address:

Carotenoids are regarded as a cornerstone of avian vitality and coloration. Currently, the antioxidant potential of dietary carotenoids is debated for birds. Although some studies support a protective role, others report either no effect or pro-oxidant effects. Read More

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http://dx.doi.org/10.1016/j.cbpb.2019.02.003DOI Listing
February 2019

Skin and soft tissue infection caused by Cutibacterium (formerly Propionibacterium) avidum: report of eleven cases.

Anaerobe 2019 Feb 19. Epub 2019 Feb 19.

Section of Microbiology, University Hospital of Guadalajara, Guadalajara, Spain.

We describe the characteristics of 11 cases of skin and soft tissue infections due to Cutibacterium (formerly Propionibacterium) avidum. This microorganism should be considered a potential skin pathogen especially in patients with breast infections. The clinical outcome is usually good but serious infections such as necrotizing infections may occur. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.013DOI Listing
February 2019

Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration.

J Pharm Sci 2019 Feb 19. Epub 2019 Feb 19.

It is of great challenge to predict human brain penetration for substrates of multidrug resistance protein 1 (MDR1) and/or breast cancer resistance protein (BCRP), two major efflux transporters at blood-brain barrier. Thus, a PBPK model with the incorporation of in vitro MDR1 and BCRP transporter function data and transporter protein expression levels has been developed. As such, it is crucial to generate MDR1 and BCRP substrate data with a high fidelity. Read More

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http://dx.doi.org/10.1016/j.xphs.2019.02.005DOI Listing
February 2019

Home-Based Interventions in a Case of First Latch at 27 Days.

Authors:
Natsuko Wood

Nurs Womens Health 2019 Feb 19. Epub 2019 Feb 19.

In this article, I describe the effects of home interventions on latching difficulty that persisted for 27 days for a mother-neonate dyad. The neonate manifested latching difficulty immediately after cesarean birth, and it became worse when nipple shields, bottles, and pacifiers were introduced. Manual expression and an electric pump were implemented when the neonate started losing weight, resulting in reduced frequency of breastfeeding directly at the breast. Read More

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http://dx.doi.org/10.1016/j.nwh.2019.01.004DOI Listing
February 2019

Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models.

PLoS Comput Biol 2019 Feb 22;15(2):e1006799. Epub 2019 Feb 22.

Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a novel machine learning formalism for improved signature inference, based on multi-modal correlated topic models (MMCTM) which can at once infer signatures from both single nucleotide and structural variation counts derived from cancer genome sequencing data. We exemplify the utility of our approach on two hormone driven, DNA repair deficient cancers: breast and ovary (n = 755 samples total). Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006799DOI Listing
February 2019

Utility of Sry-Related HMG-Box Gene 10 (SOX10) as a marker of melanoma in effusion cytology.

Diagn Cytopathol 2019 Feb 22. Epub 2019 Feb 22.

Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio.

Background: The cytodiagnosis of melanoma in effusions can be challenging. Although immunohistochemical (IHC) stains such as HMB45, Melan A, and S-100 are often utilized; the role of Sry-related HMG-box gene 10 (SOX10) in the diagnosis of melanoma in effusions has not been previously reported.

Methods: A total of 14 confirmed melanoma cases diagnosed on effusion cytology (nine pleural and five peritoneal) were collected from 2000 to 2016. Read More

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http://dx.doi.org/10.1002/dc.24162DOI Listing
February 2019

Methylation-based biological age and breast cancer risk.

J Natl Cancer Inst 2019 Feb 22. Epub 2019 Feb 22.

Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC.

Background: Age is one of the strongest predictors of cancer, chronic disease and mortality, but biological responses to aging differ among people. Epigenetic DNA modifications have been used to estimate "biological age," which may be a useful predictor of disease risk. We test this hypothesis for breast cancer. Read More

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http://dx.doi.org/10.1093/jnci/djz020DOI Listing
February 2019

Association of Prepubertal and Adolescent Androgen Concentrations With Timing of Breast Development and Family History of Breast Cancer.

JAMA Netw Open 2019 Feb 1;2(2):e190083. Epub 2019 Feb 1.

Department of Epidemiology, Columbia University Mailman School of Public Health, New York, New York.

Importance: Early breast development is a risk factor for breast cancer, and girls with a breast cancer family history (BCFH) experience breast development earlier than girls without a BCFH.

Objectives: To assess whether prepubertal androgen concentrations are associated with timing of breast development (analysis 1) and to compare serum androgen concentrations in girls with and without a BCFH (analysis 2).

Design, Setting, And Participants: Prospective cohort study of 104 girls aged 6 to 13 years at baseline using data collected between August 16, 2011, and March 24, 2016, from the Lessons in Epidemiology and Genetics of Adult Cancer From Youth (LEGACY) Girls Study, New York site. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.0083DOI Listing
February 2019

Posttraumatic growth experiences and its contextual factors in women with breast cancer: An integrative review.

Health Care Women Int 2019 Feb 22:1-27. Epub 2019 Feb 22.

c School of Nursing and Midwifery , Latrobe University , Melbourne , VIC , Australia.

In this article, we synthesize current research that examines determinants and manifestations of posttraumatic growth (the phenomenon of posttraumatic growth can be embodied in several domains) in women with breast cancer. The findings of the integrative literature review may contribute to facilitating person-centered oncology care by raising health care professionals' awareness and understanding of posttraumatic growth phenomenon among breast cancer survivors. The identification of factors contributing to posttraumatic growth and manifestations of posttraumatic growth are important in increasing the effectiveness of interventions in supporting women during their breast cancer journey. Read More

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http://dx.doi.org/10.1080/07399332.2019.1578360DOI Listing
February 2019

Correlation-adjusted regression survival scores for high-dimensional variable selection.

Stat Med 2019 Feb 22. Epub 2019 Feb 22.

Department of Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Bonn, Germany.

Background: The development of classification methods for personalized medicine is highly dependent on the identification of predictive genetic markers. In survival analysis, it is often necessary to discriminate between influential and noninfluential markers. It is common to perform univariate screening using Cox scores, which quantify the associations between survival and each of the markers to provide a ranking. Read More

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http://dx.doi.org/10.1002/sim.8116DOI Listing
February 2019

Predictors affecting complications and aesthetic outcomes in autologous breast reconstruction with free muscle-sparing transverse rectus abdominis myocutaneous flaps.

Microsurgery 2019 Feb 22. Epub 2019 Feb 22.

Department of Plastic Surgery, Korea University Anam Hospital, Seoul, South Korea.

Background: Identification and understanding of predictors for complications and aesthetic outcomes in free muscle-sparing transverse rectus abdominis myocutaneous (MS-TRAM) flap are essential for successful breast reconstruction. The purpose of this study was to investigate predictors for complications and aesthetic outcomes in patients who underwent autologous breast reconstruction with free MS-TRAM flaps.

Patients And Methods: Between March 2003 and September 2017, a total of 214 patients who underwent breast reconstruction with MS-TRAM flaps were included in this study. Read More

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http://dx.doi.org/10.1002/micr.30442DOI Listing
February 2019

Synthesis of 4- epi-Parviflorons A, C and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives.

J Org Chem 2019 Feb 22. Epub 2019 Feb 22.

The first syntheses of 4- epi-parviflorons A, C, and E (4- epi-1-3) were achieved in 12-13 steps from commercially available (-)-abietic acid (5). All synthesized compounds, including intermediates and derivatives, were evaluated for antiproliferative activity against five human tumor cell lines. A structure-activity relationship study revealed the importance of two oxygen functional groups at C-11 and C-12 for cytotoxic activity, as well as a combination of carbomethoxy at C4 and a benzoyl ester with electron-drawing group at C-12 or hydroxymethyl at C4 and an appropriate oxidation stage of ring-B/C for triple-negative breast cancer cell selectivity. Read More

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http://dx.doi.org/10.1021/acs.joc.8b02832DOI Listing
February 2019

Strengthening advocacy and policy change for infant and young child feeding.

Matern Child Nutr 2019 Feb;15 Suppl 2:e12749

Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.

The creation of environments that are more supportive of optimal infant and young child feeding (IYCF) requires countries to enact policies, such as those related to the Maternity Protection Convention, the International Code of Marketing of Breast-milk Substitutes (the Code), and the Baby-Friendly Hospital Initiative. However, challenges are experienced in the translation of international policy standards into national legal measures, and there is an important gap in understanding how countries achieve progress. Policy advocacy is a nearly universal feature, but there are methodological challenges and few studies evaluating strategies and effects. Read More

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http://dx.doi.org/10.1111/mcn.12749DOI Listing
February 2019

Translating the International Code of Marketing of Breast-milk Substitutes into national measures in nine countries.

Matern Child Nutr 2019 Feb;15 Suppl 2:e12730

Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA.

The International Code of Marketing of Breast-milk Substitutes (the Code) adopted by the World Health Assembly (WHA) in 1981 and regularly updated through subsequent WHA resolutions, represents the international policy framework for protecting breastfeeding against inappropriate marketing practices. By March 2016, at least 135 countries had some measures covering provisions of the Code in their legislation. The translation of the International Code into national measures was investigated in the context of the advocacy efforts undertaken by the Alive & Thrive (A&T) initiative with UNICEF and partners. Read More

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http://dx.doi.org/10.1111/mcn.12730DOI Listing
February 2019

Non-invasive analysis of tumor mutation profiles and druggable mutations by sequencing of cell free DNA of Chinese metastatic breast cancer patients.

Thorac Cancer 2019 Feb 21. Epub 2019 Feb 21.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.

Background: Metastatic breast cancer (MBC) remains an incurable disease worldwide. Tumor gene mutations have evolved and led to drug resistance in the treatment course of MBC. However, data on the mutation profiles and druggable genomic alterations of MBC remain limited, particularly among Chinese patients. Read More

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http://dx.doi.org/10.1111/1759-7714.13002DOI Listing
February 2019

Resistance to bortezomib in breast cancer cells that downregulate Bim through FOXA1 O-GlcNAcylation.

J Cell Physiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Biochemistry, School of Life Science & Medicine, Dalian University of Technology, Panjin, China.

Bortezomib (BTZ), a well-established proteasome inhibitor used in the clinical therapy, leads the modulation of several biological alterations and in turn induces apoptosis. Although clinical trials with BTZ have shown promising results for some types of cancers, but not for some others, including those of the breast. The molecular basis of BTZ resistance in breast cancer remains elusive. Read More

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http://dx.doi.org/10.1002/jcp.28376DOI Listing
February 2019

Upregulation of DLEU1 expression by epigenetic modification promotes tumorigenesis in human cancer.

J Cell Physiol 2019 Feb 21. Epub 2019 Feb 21.

Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.

The function of DLEU1 in human cancer is largely unknown. The Cancer Genome Atlas data were applied to identify the landscape of differential genes between tumor tissues and normal tissues, which was further validated by our cohort data and pan-cancer data including 33 cancer types with 11,060 patients. Next, DLEU1 was selected to validate the novel finding and result showed that it promoted tumorigenesis in vitro and in vivo. Read More

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http://dx.doi.org/10.1002/jcp.28364DOI Listing
February 2019

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers.

Pathol Oncol Res 2019 Feb 21. Epub 2019 Feb 21.

Genome Research Chair, College of Science, King Saud University, Riyadh, Saudi Arabia.

Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Several lncRNAs can be classified into oncogenes and tumor suppressor genes depending on their function in cancer. A maternally expressed gene 3 (MEG3) gene transcripts a 1. Read More

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http://dx.doi.org/10.1007/s12253-019-00614-3DOI Listing
February 2019

Biomarker discordance between primary breast cancer and bone or bone marrow metastases.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Breast and Medical Oncology, National Cancer Center Hospital.

Background: Discordance in biomarker expression between primary and metastatic tumor sites has been reported in several studies; yet, few have examined this feature in bone lesions.

Methods: We retrospectively enrolled patients with breast cancer metastasis to the bone or bone marrow, excluding cases where samples from both the primary and metastatic lesions were not available. Expression patterns of the estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2) and Ki67 were compared in primary tumors and bone or bone marrow lesions. Read More

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http://dx.doi.org/10.1093/jjco/hyz018DOI Listing
February 2019

The use of whole body calorimetry to compare measured versus predicted energy expenditure in postpartum women.

Am J Clin Nutr 2019 Feb 22. Epub 2019 Feb 22.

Department of Agricultural, Food and Nutritional Science, University of Alberta, Canada.

Background: Accurate assessment of energy expenditure may support weight-management recommendations. Measuring energy expenditure for each postpartum woman is unfeasible; therefore, accurate predictive equations are needed.

Objectives: This study compared measured with predicted resting energy expenditure (REE) and total energy expenditure (TEE) in postpartum women. Read More

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http://dx.doi.org/10.1093/ajcn/nqy312DOI Listing
February 2019

Smartphone problem-solving therapy to reduce fear of cancer recurrence among breast cancer survivors: an open single-arm pilot study.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Division of Psycho-Oncology and Palliative Care, Nagoya City University Hospital, Mizuho-cho, Mizuho-ku, Nagoya, Japan.

Objectives: The purpose of this study was to investigate a newly developed smartphone problem-solving therapy (PST) application's feasibility and preliminary effectiveness for reducing fear of cancer recurrence (FCR) among breast cancer survivors.

Methods: Female disease-free breast cancer survivors aged 20-49 years who were more than 6 months post-breast surgery participated in the study. The patients received the smartphone PST using an iPhone or iPad for 8 weeks. Read More

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http://dx.doi.org/10.1093/jjco/hyz005DOI Listing
February 2019

A platinum(iv) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis.

Dalton Trans 2019 Feb 22. Epub 2019 Feb 22.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China.

A PtIV prodrug (PDMA) exhibits great potential for the therapy of metastatic triple-negative breast cancer (TNBC) through a synergistic action of antiangiogensis and antimetastasis. Read More

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http://dx.doi.org/10.1039/c9dt00335eDOI Listing
February 2019

Supporting data sharing.

NPJ Breast Cancer 2019 13;5. Epub 2019 Feb 13.

2Memorial Sloan-Kettering Cancer Center, New York, NY USA.

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http://dx.doi.org/10.1038/s41523-019-0103-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374458PMC
February 2019

Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma.

Biomed Res Int 2019 17;2019:1407167. Epub 2019 Jan 17.

Istanbul University, Institute of Oncology, Department of Basic Oncology, Cancer Genetics Division, Istanbul, Turkey.

Epigenetic changes have major role in the normal development and programming of gene expression. Aberrant methylation results in carcinogenesis. The primary objective of our study is to determine whether primary tumor tissue and cultured tumor cells in 2D and 3D tissue culture systems have the same methylation signature for , , and . Read More

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http://dx.doi.org/10.1155/2019/1407167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354143PMC
January 2019

Syringomatous Tumour Presenting as Inversion of a Supernumerary Nipple.

Case Rep Pathol 2019 17;2019:9461815. Epub 2019 Jan 17.

Department of Pathology, Zealand University Hospital, Slagelse, Denmark.

Syringomatous tumour (SyT) is a rare type of benign locally infiltrative tumour with debated origin. Because of the growth pattern, SyT can be mistaken for a malignant tumour, and it is therefore important to keep this diagnosis in mind. This case presents a woman with two supernumerary nipples on each side of the abdomen. Read More

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http://dx.doi.org/10.1155/2019/9461815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354169PMC
January 2019

Massive adult cystic lymphangioma of the breast.

J Surg Case Rep 2019 Feb 12;2019(2):rjz027. Epub 2019 Feb 12.

Department of Surgery, Mercy Hospital and Medical Center, Chicago, IL, USA.

Adult cystic lymphangiomas are exceedingly rare tumors resulting from malformation of the lymphatic vessels. Like their pediatric counterparts, these lesions almost exclusively involve the head and neck. However, adult cystic lymphangiomas have been reported in several organs. Read More

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http://dx.doi.org/10.1093/jscr/rjz027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371853PMC
February 2019

Access to high-cost drugs for advanced breast cancer in Latin America, particularly trastuzumab.

Ecancermedicalscience 2019 22;13:898. Epub 2019 Jan 22.

Latin American Cooperative Oncology Group, 99 A, Av Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil.

Provision of high-level healthcare is a challenge for all low- to middle-income countries (LMICs) since healthcare systems are heterogeneous, face many challenges such as inadequate funding, inequitable distribution of resources and services and usually are not adequately equipped to deal with a huge problem such as breast cancer. The development of anti-HER2 therapies can be considered one of the most important examples of the translation of molecular biology knowledge into clinical benefits for cancer patients. While a variety of novel therapeutic strategies are emerging, current treatment regimens remain focussed on targeted therapy with monoclonal antibodies, mainly trastuzumab, the first agent developed in this field. Read More

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http://dx.doi.org/10.3332/ecancer.2019.898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372298PMC
January 2019

Barriers in Latin America for the management of locally advanced breast cancer.

Ecancermedicalscience 2019 22;13:897. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Peru.

Breast cancer (BC) is a highly prevalent malignancy in Latin American women, most cases being diagnosed at locally advanced or metastatic stages when options for cancer care are limited. Despite its label as a public health problem in the region, Latin American BC patients face several barriers in accessing standard of care treatment when compared with patients from developed countries. In this review, we analyse the landscape of the four main identified barriers in the region: i) high burden of locally advanced/advanced BC; ii) inadequate access to medical resources; iii) deficient access to specialised cancer care and iv) insufficient BC research in Latin America. Read More

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http://dx.doi.org/10.3332/ecancer.2019.897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372299PMC
January 2019

Precision medicine for locally advanced breast cancer: frontiers and challenges in Latin America.

Ecancermedicalscience 2019 22;13:896. Epub 2019 Jan 22.

Departamento de Medicina Oncológica, Oncosalud-AUNA, Lima 15036, Perú.

Advances in high-throughput technologies and their involvement in the 'omics' of cancer have made possible the identification of hundreds of biomarkers and the development of predictive and prognostic platforms that model the management of cancer from evidence-based medicine to precision medicine. Latin America (LATAM) is a region characterised by fragmented healthcare, high rates of poverty and disparities to access to a basic standard of care not only for cancer but also for other complex diseases. Patients from the public setting cannot afford targeted therapy, the facilities offering genomic platforms are scarce and the use of high-precision radiotherapy is limited to few facilities. Read More

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http://dx.doi.org/10.3332/ecancer.2019.896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372295PMC
January 2019

Locally advanced breast cancer in Brazil: current status and future perspectives.

Ecancermedicalscience 2019 22;13:895. Epub 2019 Jan 22.

Latin American Cooperative Oncology Group, Porto Alegre 90619-900, Brazil.

Breast cancer (BC) is the most frequent cancer and the main cause of cancer deaths among women worldwide and in Brazil. A high proportion of patients are diagnosed with locally advanced breast cancer (LABC) in Brazil, mainly due to limited coverage of screening programmes. A disparity in the access to optimal treatment is evident between the public and private health systems which impact patient outcomes. Read More

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http://dx.doi.org/10.3332/ecancer.2019.895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372296PMC
January 2019

Locally advanced breast cancer in young women in Latin America.

Ecancermedicalscience 2019 22;13:894. Epub 2019 Jan 22.

CONACYT fellow-Epidemiology Unit, Mexican National Cancer Institute, Mexico City 14080, Mexico.

The purpose of this review is to organise, summarise and critically assess existing knowledge on locally advanced breast cancer (LABC) among young women in Latin America. We discuss the most relevant findings in six sections: 1) epidemiology of breast cancer in young women in Latin America; 2) being young as a factor for worse prognosis; 3) LABC in young women in the region; 4) aggressive tumour behaviour among young women; 5) delays in diagnosis and treatment and 6) burden of advanced disease. We point out the need to dedicate resources to enhance earlier diagnosis and prompt referrals of young women with breast cancer; promote research regarding prevalence, biologic characteristics, outcomes and reasons for diagnosis and treatment delays for this age group; and finally, implement supportive care programmes as a means of improving patients and their families' well-being. Read More

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http://dx.doi.org/10.3332/ecancer.2019.894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372300PMC
January 2019

Triple-negative breast cancer: the reality in Chile and in Latin America.

Ecancermedicalscience 2019 22;13:893. Epub 2019 Jan 22.

Oncology Institute Arturo López Pérez Foundation, Santiago 878, Chile.

Breast cancer is the leading cause of cancer death among women worldwide. While triple-negative breast cancer is less common among various sub-types of breast cancer, it tends to affect younger women and is more aggressive, having a higher rate of early recurrence and mortality compared to other sub-types. We know about the association between triple-negative breast cancer and BRCA mutations, which are highly prevalent in founding populations of European origin, but the true prevalence of these mutations in Latin American populations is unknown. Read More

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http://dx.doi.org/10.3332/ecancer.2019.893DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372297PMC
January 2019

Proteomics characterisation of central nervous system metastasis biomarkers in triple negative breast cancer.

Ecancermedicalscience 2019 15;13:891. Epub 2019 Jan 15.

Biomedica Molecular Medicine SL, 28049 Madrid, Spain.

Background: Breast cancer (BC) is the most frequent tumour in women. Triple negative tumours (TNBC)-which are associated with minor survival rates-lack markers predictive of response to anticancer drugs. Triple negative tumours frequently metastasise to the central nervous system (CNS). Read More

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http://dx.doi.org/10.3332/ecancer.2019.891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369972PMC
January 2019

Distribution of bioactive factors in human milk samples.

Int Breastfeed J 2019 11;14. Epub 2019 Feb 11.

1Department of Anatomy, MTA-PTE PACAP Research Group, Centre for Neuroscience, Medical School, University of Pécs, Pécs, Hungary.

Background: Breast milk provides nutrition for infants and also contains a variety of bioactive factors that influence the development of the newborn. Human milk is a complex biological fluid that can be separated into different layers (water phase and lipid phase with its component water and lipid fractions). It can affect the developing human body along the whole length of the gastrointestinal tract, and through the circulation, its factors may reach every organ. Read More

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http://dx.doi.org/10.1186/s13006-019-0203-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371541PMC
February 2019

Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer.

Int J Biomed Imaging 2019 17;2019:5987425. Epub 2019 Jan 17.

Department of Radiology, The University of Chicago, Chicago, Illinois 60637, USA.

Breast cancer is a major cause of morbidity and mortality in Western women. Tumor neoangiogenesis, the formation of new blood vessels from pre-existing ones, may be used as a prognostic marker for cancer progression. Clinical practice uses dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to detect cancers based on increased blood flow and capillary permeability. Read More

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http://dx.doi.org/10.1155/2019/5987425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354161PMC
January 2019

Transcriptome Sequencing Investigated the Tumor-Related Factors Changes After Infection.

Front Microbiol 2019 7;10:181. Epub 2019 Feb 7.

Department of Ji Nan Children's Hospital, Jinan, China.

is an intracellular parasite and causes a global epidemic parasitic disease. infection could inhibit the growth of tumor. In this study, the transcriptomes of samples were detected by deep sequencing analysis. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374557PMC
February 2019

Treatment of Chemotherapy-Induced Thrombotic Microangiopathy with Eculizumab in a Patient with Metastatic Breast Cancer.

Case Rep Oncol 2019 Jan-Apr;12(1):1-6. Epub 2019 Jan 3.

Dialysis Center Ludwigsburg, Ludwigsburg, Germany.

The unexpected occurrence of thrombotic microangiopathy (TMA), characterised by microangiopathic haemolytic anaemia and thrombocytopenia, in a patient with cancer requires urgent diagnosis and appropriate management. TMA in patients with metastatic cancer can be a manifestation of the malignancy itself or a therapeutic complication. Distinguishing the cause of TMA is complicated but clinically important to initiate appropriate treatment of metastatic cancer and avoid potential drug toxicity. Read More

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http://dx.doi.org/10.1159/000495031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381888PMC
January 2019

Correction to: Membrane expression of thymidine kinase 1 and potential clinical relevance in lung, breast, and colorectal malignancies.

Cancer Cell Int 2019 11;19:29. Epub 2019 Feb 11.

1Department of Microbiology and Molecular Biology, Brigham Young University, 3142 Life Sciences Building, Provo, UT 84602 USA.

[This corrects the article DOI: 10.1186/s12935-018-0633-9.]. Read More

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http://dx.doi.org/10.1186/s12935-019-0749-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369547PMC
February 2019

MicroRNAs in Female Malignancies.

Cancer Inform 2019 13;18:1176935119828746. Epub 2019 Feb 13.

University of Aberdeen, School of Medicine and Dentistry, Aberdeen, UK.

MicroRNAs (miRNAs) are endogenous 22-nucleotide RNAs that can play a fundamental regulatory role in the gene expression of various organisms. Current research suggests that miRNAs can assume pivotal roles in carcinogenesis. In this article, through bioinformatics mining and computational analysis, we determine a single miRNA commonly involved in the development of breast, cervical, endometrial, ovarian, and vulvar cancer, whereas we underline the existence of 7 more miRNAs common in all examined malignancies with the exception of vulvar cancer. Read More

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http://dx.doi.org/10.1177/1176935119828746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376555PMC
February 2019

Mechanisms of Metastasis and Cell Mobility - The Role of Metabolism.

Geburtshilfe Frauenheilkd 2019 Feb 18;79(2):184-188. Epub 2019 Feb 18.

Universitätsmedizin Göttingen, Klinik für Gynäkologie und Geburtshilfe, Göttingen, Germany.

Tumour metastasis is responsible for more than 90% of tumour-associated mortality. About one third of breast cancer patients in the early stage develop metastases. The transformation in tumour development referred to as the "metastatic cascade" or "metastatic cycle" is a complex and multi-stage event. Read More

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http://dx.doi.org/10.1055/a-0805-9113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379160PMC
February 2019

Circulating and Disseminated Tumour Cells in Breast Carcinoma: Report from the Consensus Conference on Tumour Cell Dissemination during the 38th Annual Meeting of the German Society of Senology, Berlin, 14 June 2018.

Geburtshilfe Frauenheilkd 2019 Feb 14;79(2):177-183. Epub 2019 Jan 14.

Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.

Haematogenic dissemination of tumour cells in breast carcinoma is among the most intensively researched areas in translational oncology. Large meta-analyses have shown the prognostic relevance of the disseminated tumour cells in the bone marrow and circulating tumour cells in the peripheral blood in the adjuvant as well as metastatic setting. The current status of the research was discussed in detail during the annual meeting of the German Society of Senology in Berlin. Read More

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http://dx.doi.org/10.1055/a-0753-7331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379163PMC
February 2019

BRAF V600E and SRC mutations as molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer.

Sci Rep 2019 Feb 21;9(1):2466. Epub 2019 Feb 21.

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Comprehensive genomic sequencing (CGS) enables us to detect numerous genetic alterations in a single assay. We aimed to identify molecular markers for predicting prognosis and conversion surgery in Stage IV colorectal cancer (CRC) using CGS. One-hundred eleven patients with Stage IV CRC who underwent primary tumor resection were analyzed. Read More

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http://dx.doi.org/10.1038/s41598-019-39328-6DOI Listing
February 2019

Dynamic Effects of CYP2D6 Genetic Variants in a Set of Poor Metaboliser Patients with Infiltrating Ductal Cancer Under Treatment with Tamoxifen.

Sci Rep 2019 Feb 21;9(1):2521. Epub 2019 Feb 21.

Universidad Simón Bolivar, Facultad de Ciencias Básicas y Biomédicas, Laboratorio de Simulación Molecular y Bioinformática, Barranquilla, 080002, Colombia.

Breast cancer is a group of multigenic diseases. It is the most common cancer diagnosed among women worldwide and is often treated with tamoxifen. Tamoxifen is catalysed by cytochrome P450 2D6 (CYP2D6), and inter-individual variations in the enzyme due to single nucleotide polymorphisms (SNPs) could alter enzyme activity. Read More

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http://dx.doi.org/10.1038/s41598-018-38340-6DOI Listing
February 2019

Detection of Volatile Organic Compounds (VOCs) in Urine via Gas Chromatography-Mass Spectrometry QTOF to Differentiate Between Localized and Metastatic Models of Breast Cancer.

Sci Rep 2019 Feb 21;9(1):2526. Epub 2019 Feb 21.

IUPUI, Department of Chemistry and Chemical Biology, Indianapolis, 46202, USA.

Breast cancer is the most common cancer detected in women and current screening methods for the disease are not sensitive. Volatile organic compounds (VOCs) include endogenous metabolites that provide information about health and disease which might be useful to develop a better screening method for breast cancer. The goal of this study was to classify mice with and without tumors and compare tumors localized to the mammary pad and tumor cells injected into the iliac artery by differences in VOCs in urine. Read More

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http://dx.doi.org/10.1038/s41598-019-38920-0DOI Listing
February 2019

Potassium channel activity controls breast cancer metastasis by affecting β-catenin signaling.

Cell Death Dis 2019 Feb 21;10(3):180. Epub 2019 Feb 21.

Department of Molecular Pharmacology & Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, 60153, USA.

Potassium ion channels are critical in the regulation of cell motility. The acquisition of cell motility is an essential parameter of cancer metastasis. However, the role of K channels in cancer metastasis has been poorly studied. Read More

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http://dx.doi.org/10.1038/s41419-019-1429-0DOI Listing
February 2019

miR-29a contributes to breast cancer cells epithelial-mesenchymal transition, migration, and invasion via down-regulating histone H4K20 trimethylation through directly targeting SUV420H2.

Cell Death Dis 2019 Feb 21;10(3):176. Epub 2019 Feb 21.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, School of life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, Jiangsu province, China.

Breast cancer is the most prevalent cancer in women worldwide, which remains incurable once metastatic. Breast cancer stem cells (BCSCs) are a small subset of breast cancer cells which are essential in tumor formation, metastasis, and drug resistance. microRNAs (miRNAs) play important roles in the breast cancer cells and BCSCs by regulating specific genes. Read More

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http://dx.doi.org/10.1038/s41419-019-1437-0DOI Listing
February 2019

Angiomotin-p130 inhibits β-catenin stability by competing with Axin for binding to tankyrase in breast cancer.

Cell Death Dis 2019 Feb 21;10(3):179. Epub 2019 Feb 21.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Growing evidence indicates that Angiomotin (Amot)-p130 and Amot-p80 have different physiological functions. We hypothesized that Amot-p130 is a tumor suppressor gene in breast cancer, in contrast with the canonical oncogenicity of Amot-p80 or total Amot. To clarify the role of Amot-p130 in breast cancer, we performed real-time quantitative PCR, western blotting, flow cytometry, microarray, immunofluorescence, immunoprecipitation, and tumor sphere-formation assays in vitro, as well as tumorigenesis and limited-dilution analysis in vivo. Read More

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http://dx.doi.org/10.1038/s41419-019-1427-2DOI Listing
February 2019

Comparison of different motion correction techniques for dynamic FDG-PET/CT studies in breast cancer patients.

Q J Nucl Med Mol Imaging 2019 Feb 21. Epub 2019 Feb 21.

Pozitron PET/CT Center, Budapest, Hungary.

Background: Our aim was evaluate interchangeability of different motion correction methods in the assessment of dynamic FDG-PET/CT studies in breast cancer patients as well as to assess the interrater reliability of these methods.

Methods: In our prospective study we included patients with malignant breast tumours. Dynamic PET acquisition lasted for 60 minutes after tracer (FDG) injection. Read More

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http://dx.doi.org/10.23736/S1824-4785.19.03114-5DOI Listing
February 2019

HER2 Expression in NF1 Breast Cancer-Response.

Cancer Prev Res (Phila) 2019 Feb 21. Epub 2019 Feb 21.

Henry Ford Hospital, Detroit, Michigan.

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0492DOI Listing
February 2019

Alterations are Linked to Increased HER2 Expression in Breast Cancer-Letter.

Cancer Prev Res (Phila) 2019 Feb 21. Epub 2019 Feb 21.

Division of Pathology, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0392DOI Listing
February 2019