510,056 results match your criteria Breast Edinburgh Scotland[Journal]


Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, P.R. China.

Circular RNAs (circRNAs) play an important role in the tumorigenesis of hepatocellular carcinoma (HCC), but their specific functions in HCC remain largely unknown. Using bioinformatics analysis, we have found that the expression of circRNA hsa_circ_0003141 is significantly increased in HCC tissues. Ubiquitin-associated protein 2 (UBAP2) is the parent gene for hsa_circ_0003141, and its high expression correlates with poor overall survival rates in HCC patients. Read More

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http://dx.doi.org/10.18632/aging.103244DOI Listing

Can you draw the picture of happiness- Treatment of a young woman with breast cancer during the COVID-19 pandemic.

Asian J Psychiatr 2020 May 19;52:102174. Epub 2020 May 19.

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, USA.; Department of Internal Medicine, Division of Medical Oncology, Gaziosmanpasa University, Faculty of Medicine, Tokat, Turkey.

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http://dx.doi.org/10.1016/j.ajp.2020.102174DOI Listing

The effects of shift work and sleep duration on cancer incidence in Alberta`s Tomorrow Project cohort.

Cancer Epidemiol 2020 May 25;67:101729. Epub 2020 May 25.

Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Alberta, Canada; Departments of Oncology and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Introduction: We investigated the main effects of shift work and sleep duration on cancer incidence, and effect modification of the shift work-cancer incidence association by sleep duration.

Methods: Shift work and sleep duration were assessed among 21,804 participants from Alberta`s Tomorrow Project. Incident cases of breast, prostate, colorectal and lung cancers were identified through registry linkage. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101729DOI Listing

Gene expression signatures: A tool for analysis of breast cancer prognosis and therapy.

Crit Rev Oncol Hematol 2020 May 15;151:102964. Epub 2020 May 15.

Cancer Research Program 6, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India. Electronic address:

Breast Cancer is the most predominant female cancer in developed as well as developing countries. The treatment strategies of breast cancers depends on an array of factors like age at diagnosis, menstrual status, dietary pattern, immunological response, genetic variations of the cancer cells etc. Recent technological advancements in cancer diagnosis lead to the emergence of gene expression pattern for better understanding of the tumor behavior. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2020.102964DOI Listing

Factors affecting early-life intestinal microbiota development.

Nutrition 2020 Mar 25;78:110812. Epub 2020 Mar 25.

Ulm University Hospital, Department of Pediatrics and Adolescent Medicine, Division of Pediatric Endocrinology and Diabetes, Centre for Hormonal Disorders in Children and Adolescents, Ulm, Germany.

Objectives: This paper reviews the published evidence on early-life intestinal microbiota development, as well as the different factors influencing its development before, at, and afterbirth. A literature search was done using PubMed, Cochrane and EMBASE databases. A growing body of evidence indicates that the intrauterine environment is not sterile as once presumed, but that maternal-fetal transmission of microbiota occurs during pregnancy. Read More

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http://dx.doi.org/10.1016/j.nut.2020.110812DOI Listing

Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents.

Eur J Med Chem 2020 May 1;198:112396. Epub 2020 May 1.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

A novel series of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents were designed, synthesized, biologically evaluated. Compounds 3n, 3o and 3j proved to be good NQO1 substrates that showed increased metabolic rates relative to that of β-lapachone. In addition, 3n, 3o and 3j potently inhibited the growth of NQO1-rich breast cancer MCF-7 cell, liver hepatocellular HepG2 cell, and lung cancer A549 cell. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112396DOI Listing

Improved tolerability of neratinib in patients with HER2-positive early-stage breast cancer: diarrheal toxicity in the CONTROL trial.

Ann Oncol 2020 May 25. Epub 2020 May 25.

Breast Cancer Research Centre-WA & Curtin University, Perth, WA, Australia.

Background: Neratinib is an irreversible pan-HER tyrosine kinase inhibitor approved for extended adjuvant treatment in early-stage HER2-positive breast cancer based on the phase III ExteNET study. In that trial, in which no anti-diarrheal prophylaxis was mandated, grade 3 diarrhea was observed in 40% of patients and 17% discontinued due to diarrhea. The international, open-label, sequential-cohort, phase II CONTROL study is investigating several strategies to improve tolerability. Read More

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http://dx.doi.org/10.1016/j.annonc.2020.05.012DOI Listing

Kopetdaghinanes, pro-apoptotic hemiacetialic cyclomyrsinanes from Euphorbia kopetdaghi.

Fitoterapia 2020 May 25:104636. Epub 2020 May 25.

Department of Clinical Biochemistry, School of Pharmacy & Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Euphorbia kopetdaghi grows wild in the Northeast parts of Iran. Phytochemical study of its aerial parts led to the isolation of two undescribed cyclomyrsinol macrocyclic diterpenes with a new tetrahydrofuran oxidation pattern containing a hemiacetal group named: kopetdaghinane A and B. The structure of the isolated compounds was elucidated by extensive spectroscopic methods. Read More

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http://dx.doi.org/10.1016/j.fitote.2020.104636DOI Listing

Folate decorated epigallocatechin-3-gallate (EGCG) loaded PLGA nanoparticles; in-vitro and in-vivo targeting efficacy against MDA-MB-231 tumor xenograft.

Int J Pharm 2020 May 25:119449. Epub 2020 May 25.

Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India. Electronic address:

Epigallocatechin-3-gallate (EGCG), a major polyphenolic constituent of green tea exhibits significant anticancer potential over a wide range of cancer cells. We have developed folate peptide decorated PLGA-NPs loaded with EGCG (FP-EGCG-NPs) to bind folate receptor (FR) specific breast cancer cell lines and evaluated their efficacy in pre-clinical studies. EGCG loaded PLGA nanoparticles (EGCG-NPs) were characterised for size, surface morphology, surface charge, encapsulation efficacy and in-vitro drug release kinetics. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119449DOI Listing

Vaccarin promotes proliferation of and milk synthesis in bovine mammary epithelial cells through the Prl receptor-PI3K signaling pathway.

Eur J Pharmacol 2020 May 25:173190. Epub 2020 May 25.

School of Animal Science, Yangtze University, Jingzhou, 434023, China. Electronic address:

Semen Vaccariae, the seed of Vaccaria segetalis, is traditionally used in East Asian countries for the treatment of breast milk deficiency, but the underlying molecular mechanism has not been discovered yet. The present study assessed the stimulatory effect of vaccarin, one of the major constituents of Semen Vaccariae, on proliferation of and milk synthesis in bovine mammary epithelial cells (BMECs) and explored the corresponding molecular mechanism. Vaccarin affected cell proliferation and milk fat and protein synthesis in a concentration-dependent manner, with the best stimulatory effects at 0. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173190DOI Listing

The risk for developing a secondary cancer after breast radiation therapy: Comparison of photon and proton techniques.

Radiother Oncol 2020 May 25. Epub 2020 May 25.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, United States; Harvard Medical School, Boston, MA, United States.

Background And Purpose: To compare secondary malignancy risks of modern proton and photon therapy techniques for locally advanced breast cancer.

Methods And Materials: We utilized dosimetric data from 34 [10 photon-VMAT, 10 photon-3DCRT, 14 pencil beam scanning proton (PBS)] breast cancer patients who received comprehensive nodal irradiation. Employing a model based on organ equivalent dose to account for both inhomogeneous organ dose distributions and non-linear functional dose relationships, we estimated excess absolute risk, excess relative risk, and lifetime attributable risk (LAR) for secondary malignancies. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.05.035DOI Listing

Risk factors for fat necrosis after stereotactic partial breast irradiation (S-PBI) for early stage breast cancer in a phase I clinical trial.

Int J Radiat Oncol Biol Phys 2020 May 25. Epub 2020 May 25.

Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

Purpose: This study reports predictive dosimetric and physiologic factors for fat necrosis after Stereotactic-Partial Breast Irradiation (S-PBI).

Materials And Methods: Seventy-five patients with ductal carcinoma-in-situ or invasive nonlobular epithelial histologies stage 0, I, or II, with tumor size <3 cm were enrolled in a dose escalation Phase I S-PBI trial between January 2011-July 2015. Fat necrosis was evaluated clinically at each follow-up. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2020.05.025DOI Listing

Hyperbaric Oxygen Therapy and Mastectomy Flap Ischemia following Nipple-Sparing Mastectomy and Immediate Breast Reconstruction.

Plast Reconstr Surg 2020 Jun;145(6):1114e-1115e

Division of Plastic Surgery, Weill Cornell Medical College Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center Institute of Reconstructive Plastic Surgery, New York University Langone Medical Center Plastic and Reconstructive Surgery Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, N.Y.

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http://dx.doi.org/10.1097/PRS.0000000000006881DOI Listing

Reply: Sensory Recovery of the Breast following Innervated and Noninnervated DIEP Flap Breast Reconstruction.

Plast Reconstr Surg 2020 Jun;145(6):1100e-1101e

Department of Plastic, Reconstructive, and Hand Surgery Department of Clinical Epidemiology and Medical Technology Assessment Department of Plastic, Reconstructive, and Hand Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1097/PRS.0000000000006874DOI Listing

Sensory Recovery of the Breast following Innervated and Noninnervated DIEP Flap Breast Reconstruction.

Plast Reconstr Surg 2020 Jun;145(6):1099e-1100e

Stoke Mandeville Hospital, Aylesbury, United Kingdom.

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http://dx.doi.org/10.1097/PRS.0000000000006873DOI Listing

Reply: A Simplified Cost-Utility Analysis of Inpatient Flap Monitoring after Microsurgical Breast Reconstruction and Implications for Hospital Length of Stay.

Authors:
Mark L Smith

Plast Reconstr Surg 2020 Jun;145(6):1098e-1099e

Division of Plastic Surgery, Northwell Health System and Cancer Institute, Lake Success, N.Y.

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http://dx.doi.org/10.1097/PRS.0000000000006872DOI Listing

A Simplified Cost-Utility Analysis of Inpatient Flap Monitoring after Microsurgical Breast Reconstruction and Implications for Hospital Length of Stay.

Plast Reconstr Surg 2020 Jun;145(6):1097e-1098e

Department of Plastic Surgery, Cleveland Clinic Division of Plastic Surgery, MetroHealth, Cleveland, Ohio.

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http://dx.doi.org/10.1097/PRS.0000000000006871DOI Listing

Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a Position Statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society.

Eur J Heart Fail 2020 May 28. Epub 2020 May 28.

Cardio-Oncology Center of Excellence, Washington University in St Louis, Missouri, USA.

This position statement from the Heart Failure Association of the European Society of Cardiology Cardio-Oncology Study Group in collaboration with the International Cardio-Oncology Society presents practical, easy-to-use and evidence-based risk stratification tools for oncologists, haemato-oncologists and cardiologists to use in their clinical practice to risk stratify oncology patients prior to receiving cancer therapies known to cause heart failure or other serious cardiovascular toxicities. Baseline risk stratification proformas are presented for oncology patients prior to receiving the following cancer therapies: anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor inhibitors, second and third generation multi-targeted kinase inhibitors for CML targeting BCR-ABL, multiple myeloma therapies (proteasome inhibitors and immunomodulatory drugs), RAF and MEK inhibitors or androgen deprivation therapies. Applying these risk stratification proformas will allow clinicians to stratify cancer patients into low, medium, high and very high risk of cardiovascular complications prior to starting treatment, with the aim of improving personalised approaches to minimise the risk of cardiovascular toxicity from cancer therapies. Read More

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http://dx.doi.org/10.1002/ejhf.1920DOI Listing

The genomic landscape of metastasis in treatment-naïve breast cancer models.

PLoS Genet 2020 May 28;16(5):e1008743. Epub 2020 May 28.

Laboratory of Cancer Biology and Genetics, Metastasis Susceptibility Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America.

Metastasis remains the principle cause of mortality for breast cancer and presents a critical challenge because secondary lesions are often refractory to conventional treatments. While specific genetic alterations are tightly linked to primary tumor development and progression, the role of genetic alteration in the metastatic process is not well-understood. The theory of tumor evolution postulated by Peter Nowell in 1976 has yet to be proven in the context of metastasis. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008743DOI Listing

Prognostic value of prostaglandin I2 synthase and its correlation with tumor-infiltrating immune cells in lung cancer, ovarian cancer, and gastric cancer.

Aging (Albany NY) 2020 May 28;12. Epub 2020 May 28.

Department of Gynecology and Obstetrics, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong, China.

Background: Prostaglandin I2 synthase (PTGIS) is a crucial gene for the synthesis of prostaglandin I2, which has multiple roles in inflammation and immune modulation. However, studies on the prognostic value of PTGIS and its correlation with tumor-infiltrating immune cells in multiple cancers are still rare.

Results: Multiple datasets of the Oncomine database showed that PTGIS was expressed at low levels in lung cancer and ovarian cancer compared to the levels in normal tissues. Read More

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http://dx.doi.org/10.18632/aging.103235DOI Listing

Question Prompt List to Support Patient-Provider Communication in the Use of the 21-Gene Recurrence Test: Feasibility, Acceptability, and Outcomes.

JCO Oncol Pract 2020 May 28:JOP1900661. Epub 2020 May 28.

Georgetown Lombardi Comprehensive Cancer Center, Washington, DC.

Purpose: The 21-gene recurrence score (RS) assay is used to guide breast cancer treatment decisions but can be poorly understood by patients. We examined the effects of a question prompt list (QPL) on knowledge, distress, and decisional conflict related to genomic testing and treatment in early-stage breast cancer.

Methods: We describe the feasibility and acceptability of the QPL and the impact of the QPL on knowledge, distress, and decisional conflict before and after the receipt of the QPL (MEND 2, N = 65). Read More

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http://dx.doi.org/10.1200/JOP.19.00661DOI Listing

Changing practice: moving to a specialist nurse-led service for BRCA gene testing.

Br J Nurs 2020 May;29(10):S6-S13

Associate Professor in Public Health, University of Nottingham.

Some 5-10% of all breast cancers are associated with a pathogenic variant in a breast cancer-associated gene (BRCA1/BRCA2). Historically, with referral to the Nottingham University Hospitals NHS Trust's clinical genetics department for genetic testing, waiting times were on average 12-14 weeks for an initial appointment and 4-6 months to obtain results from the date of testing. A specialist, nurse-led mainstreaming cancer genetics (MCG) service was set up in the trust's Nottingham Breast Institute (NBI) to: reduce waiting times for the initial consultation, counselling, consent and obtaining results for BRCA1/BRCA2 gene testing; and to ensure appropriate patients with breast cancer were offered genetic testing. Read More

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http://dx.doi.org/10.12968/bjon.2020.29.10.S6DOI Listing

Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W.

J Clin Oncol 2020 May 28:JCO1902630. Epub 2020 May 28.

Massachusetts General Hospital, Boston, MA.

Purpose: NCI-MATCH is a nationwide, histology-agnostic, signal-finding, molecular profile-driven trial for patients with refractory cancers, lymphomas, or myelomas. Patients with tumors harboring actionable aberration(s) in fibroblast growth factor receptor () were treated with AZD4547, an oral FGFR1-3 inhibitor.

Methods: Patients' tumors were screened by next-generation sequencing for predefined amplification, activating mutations, or fusions. Read More

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http://dx.doi.org/10.1200/JCO.19.02630DOI Listing

Engineering mesenchymal stem cells: a novel therapeutic approach in breast cancer.

J Drug Target 2020 May 28:1-29. Epub 2020 May 28.

Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Breast cancer is one of the most prevalent and deadliest cancers among women in the world because of its aggressive behavior and inadequate response to conventional therapies. Cellular and gene therapies based on mesenchymal stem cells (MSCs) represent promising treatment strategies for multiple diseases, such as cancers. MSCs are multipotent adult stem cells with important features for cell therapy, such as tissue homing to injured sites, their differentiation potential, their capacity of secreting plenty of trophic factors, and low immunogenicity. Read More

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http://dx.doi.org/10.1080/1061186X.2020.1775842DOI Listing

Hyaluronic Acid-Modified Au-Ag Alloy Nanoparticles for Radiation/Nanozyme/Ag+ Multimodal Synergistically Enhanced Cancer Therapy.

Bioconjug Chem 2020 May 28. Epub 2020 May 28.

Gold nanoparticles (Au NPs) have been widely documented as tumor radiosensitizers via enhanced energy deposition of ionizing radiation. However, the sensitization efficiency of Au NPs is still far from satisfactory owing to the irradiation on non-target tissues and the tumor radio-resistance. To address these issues, we report herein the rational design and development of hyaluronic acid-modified Au-Ag alloy nanoparticles (Au-Ag@HA NPs) with effective tumor radiosensitization by tumor microenvironment-activated nanocatalytic process as well as high energy deposition. Read More

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http://dx.doi.org/10.1021/acs.bioconjchem.0c00224DOI Listing

Sexual Health Communication Strategies for Breast Cancer Survivors.

Am Fam Physician 2020 Jun;101(11):644

Bethesda, MD, USA.

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Analysis of Overall Survival Benefit of Abemaciclib Plus Fulvestrant in Hormone Receptor-Positive, ERBB2-Negative Breast Cancer.

JAMA Oncol 2020 May 28. Epub 2020 May 28.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jamaoncol.2020.1513DOI Listing

Zn(ii), Cd(ii) and Hg(ii) saccharinate complexes with 2,6-bis(2-benzimidazolyl)pyridine as promising anticancer agents in breast and lung cancer cell lines via ROS-induced apoptosis.

Dalton Trans 2020 May 28. Epub 2020 May 28.

Department of Physics, Faculty of Sciences, Dokuz Eylul University, 35210 Izmir, Turkey.

New Zn(ii), Cd(ii) and Hg(ii) complexes of saccharinate (sac) and 2,6-bis(2-benzimidazolyl)pyridine (bzimpy), [Zn(bzimpy)2](sac)2·2H2O (Zn), [Cd(sac)2(bzimpy)] (Cd) and [Hg(sac)2(bzimpy)] (Hg), were prepared and fully characterized by spectroscopic methods and X-ray crystallography. In vitro anticancer screening in A549 (lung), MCF-7 (breast) and HT29 (colon) cell lines showed that Zn was highly cytotoxic against A549 and MCF-7 cells with IC50 values of 1.74 ± 0. Read More

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http://dx.doi.org/10.1039/d0dt01535kDOI Listing

Does regular quality control improve the quality of surgery in Slovenian breast cancer screening program?

Radiol Oncol 2020 May 28. Epub 2020 May 28.

Department of Surgical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.

Background The aim of our study was to evaluate the quality of surgery of Slovenian breast cancer screening program (DORA) using the requested EU standards. Furthermore, we investigated whether regular quality control over the 3-year period improved the quality of surgical management. Patients and methods Patients who required surgical management within DORA between January 1st, 2016 and December 31st, 2018 were included in the retrospective study. Read More

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http://dx.doi.org/10.2478/raon-2020-0030DOI Listing

Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.

Elife 2020 May 28;9. Epub 2020 May 28.

School of Computer Science and Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using high-throughput genetic perturbation screens. Despite this advance, few genetic interactions have been reproduced across multiple studies and many appear highly context-specific. Here, by developing a new computational approach, we identified 220 robust driver-gene associated genetic interactions that can be reproduced across independent experiments and across non-overlapping cell line panels. Read More

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http://dx.doi.org/10.7554/eLife.58925DOI Listing

Gene Expression Profiling to Delineate the Anticancer Potential of a New Alkaloid Isopicrinine From .

Integr Cancer Ther 2020 Jan-Dec;19:1534735420920711

King Abdulaziz University, Jeddah, Saudi Arabia.

has been used as a folkloric medicinal herb for treating various diseases such as diabetes, inflammatory disorders, and sore throat. Several studies have revealed the potential of this plant as an important source of phytochemicals with anticancer properties. The present study was designed to isolate a novel anticancer compound from and elucidate its mechanism of action using genomics approach. Read More

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http://dx.doi.org/10.1177/1534735420920711DOI Listing

Does Contrast-Enhanced ultrasound (CEUS) play a better role in diagnosis of Breast Lesions with Calcification? A comparison with MRI.

Br J Radiol 2020 May 28:20200195. Epub 2020 May 28.

Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China.

Objectives: To compare the efficacy of contrast-enhanced ultrasound enabled reclassification of Breast Imaging Reporting and Data System (CEUS-BI-RADS) with magnetic resonance imaging (MRI) in the diagnosis of breast lesions with calcification.

Methods: A total of 52 breast lesions with calcification from 51 patients were detected by ultrasound (US) as hyperechoic foci and categorized as BI-RADS 3-5. The 51 patients further underwent CEUS scan and MRI. Read More

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http://dx.doi.org/10.1259/bjr.20200195DOI Listing

A phase II trial of cabozantinib in hormone-receptor positive breast cancer with bone metastases.

Oncologist 2020 May 28. Epub 2020 May 28.

Massachusetts General Hospital Cancer Center, Boston, MA, 02114.

Background: We assessed the antitumor activity of cabozantinib, a potent multi-receptor oral tyrosine kinase inhibitor, in patients with hormone-receptor positive breast cancer with bone metastases.

Patients And Methods: In this single-arm multicenter phase II study, patients received an initial starting dose of 100 mg, later reduced to 60 mg per day. The primary endpoint was the bone scan response rate. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0127DOI Listing

Cancer cells display increased migration and deformability in pace with metastatic progression.

FASEB J 2020 May 28. Epub 2020 May 28.

Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.

In this study, we explored the relation between metastatic states vs the capacity of confined migration, amoeboid transition, and cellular stiffness. We compared across an isogenic panel of human breast cancer cells derived from MDA-MB-231 cells. It was observed that cells after lung metastasis have the fastest migration and lowest stiffness, with a significantly higher capacity to transition into an amoeboid mode. Read More

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http://dx.doi.org/10.1096/fj.202000101RRDOI Listing

Factors affecting enrollment in randomized controlled trials conducted for patients with metastatic breast cancer.

Jpn J Clin Oncol 2020 May 28. Epub 2020 May 28.

Faculty of Science and Engineering, Chuo University, Tokyo.

Background: It is critical to obtain informed consent from eligible patients to complete clinical trials. We investigated the factors that affect the participation rates of eligible patients.

Patients And Methods: Patients with metastatic breast cancer who were eligible for SELECT BC or SELECT BC-CONFIRM trials, randomized controlled trials conducted for patients with chemotherapy-naive metastatic breast cancer were recruited to prospective studies, SELECT BC-FEEL and SELECT BC-FEEL II, respectively. Read More

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http://dx.doi.org/10.1093/jjco/hyaa065DOI Listing

Ruthenium complexes with or -heterocyclic chelates: DNA/BSA binding, Antioxidant and Anticancer studies.

J Biomol Struct Dyn 2020 May 28:1-23. Epub 2020 May 28.

School of Chemistry and Physics, University of KwaZulu-Natal, Pietermaritzburg, South Africa.

Deoxyribonucleic acid (DNA) and bovine serum albumin (BSA) binding interactions for a series of ruthenium heterocyclic complexes were monitored using ultraviolet-visible (UV-Vis) spectrophotometry, fluorescence emission spectroscopy and agarose gel electrophoresis. Investigations of the DNA interactions for the metal complexes revealed that they are groove-binders with intrinsic binding constants in the order of 10 - 10 M. Electronic spectrophotometric DNA titrations of the -heterocyclic metal complexes illustrated hypochromism of their intraligand electronic transitions and the presence of diffuse isosbestic points which are synonymous with homogeneous binding modes. Read More

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http://dx.doi.org/10.1080/07391102.2020.1775126DOI Listing

MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820927011

Department of Breast Surgery, Shanxi Provincial Cancer Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.

Triple-negative breast cancer shows worse outcome compared with other subtypes of breast cancer. The discovery of dysregulated microRNAs and their roles in the progression of triple-negative breast cancer provide novel strategies for the treatment of patients with triple-negative breast cancer. In this study, we identified the significant reduction of miR-133 in triple-negative breast cancer tissues and cell lines. Read More

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http://dx.doi.org/10.1177/1533033820927011DOI Listing

Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.

Technol Cancer Res Treat 2020 Jan-Dec;19:1533033820928471

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China.

This study was designed to identify novel circular RNAs and the related regulatory axis to provide research targets for the diagnosis and treatment of breast cancer. The circular RNA expression microarray "GSE101123" related to breast cancer was downloaded from the Gene Expression Omnibus database. The differentially expressed circular RNAs between tumor and normal samples were screened using Limma package. Read More

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http://dx.doi.org/10.1177/1533033820928471DOI Listing

Influence of a Multidisciplinary Program of Diet, Exercise, and Mindfulness on the Quality of Life of Stage IIA-IIB Breast Cancer Survivors.

Integr Cancer Ther 2020 Jan-Dec;19:1534735420924757

University of Granada, Granada, Spain.

Integrative oncology has proven to be a useful approach to control cancer symptoms and improve the quality of life (QoL) and overall health of patients, delivering integrated patient care at both physical and emotional levels. The objective of this randomized trial was to evaluate the effects of a triple intervention program on the QoL and lifestyle of women with breast cancer. Seventy-five survivors of stage IIA-IIB breast cancer were randomized into 2 groups. Read More

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http://dx.doi.org/10.1177/1534735420924757DOI Listing

Dietary Total Antioxidant Capacity (TAC) Significantly Reduces the Risk of Site-Specific Cancers: An Updated Systematic Review and Meta-Analysis.

Nutr Cancer 2020 May 28:1-19. Epub 2020 May 28.

Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

We aimed to evaluate the possible role of dietray TAC against different types of cancers in a systematic review and meta-analyses of observational studies. A literature search of authentic electronic resources had been performed to obtain the relevant studies up to February 2020. Twenty-one studies including nine prospective and twelve case-control studies were included in the current systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1080/01635581.2020.1771385DOI Listing

Anti-HER2 therapy for breast cancer in older patients.

Future Oncol 2020 May 28. Epub 2020 May 28.

Department of Clinical Oncology, AC Camargo Cancer Center, São Paulo 01509-010, Brazil.

Older patients now form between 30 and 40% of breast cancer (BC) patients. Managing older patients with BC is particularly challenging due to the limited availability of high-quality evidence. In this review we discuss the available evidence on the efficacy and safety of anti-HER2 agents in older patients with HER2-positive BC is presented, with a particular look at the latest results of promising new agents such trastuzumab-deruxtecan. Read More

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http://dx.doi.org/10.2217/fon-2020-0036DOI Listing

Evaluation of the usefulness of antymüllerian hormone and inhibin B as markers of ovarian activity in patients with Turner syndrome - preliminary results.

Pediatr Endocrinol Diabetes Metab 2020 May 28. Epub 2020 May 28.

Department of Pediatric and Adolescent Endocrinology, Jagiellonian University Collegium Medicum, Krakow, Poland.

Introduction: Spontaneous puberty occurs in 30% of patients with Turner Syndrome. Its absence is an indication for hormone replacement therapy (HRT). No reliable markers of spontaneous puberty have been defined to date. Read More

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http://dx.doi.org/10.5114/pedm.2020.95622DOI Listing

[Breast cancer in young women: implications for clinical practice].

Rev Med Suisse 2020 May;16(695):1106-1113

Centre du sein, Service de gynécologie et obstétrique, Département femme-enfant, Hôpital de Sion, Avenue du Grand-Champsec 86, 1951 Sion.

Breast cancer is the most frequently diagnosed neoplasm and principal one responsible for most death in women, specially under the age of 40. Hereditary and genetic syndromes are more prevalent among young breast cancer patients and require genetic counseling. Young women also exhibit larger tumors, with more frequent nodal involvement and aggressive features (triple negative, high grade and proliferation rate) than menopausal women. Read More

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[Breast cancer: perspectives from integrative medicine].

Rev Med Suisse 2020 May;16(695):1102-1105

Centre du sein, Département d'oncologie, CHUV, 1011 Lausanne.

Integrative medicine combines the virtues of conventional medicine and complementary medicine in order to improve the quality of life of patients suffering from cancer. Thanks to a multidisciplinary and multi-professional team, the Center for integrative and complementary medicine (CEMIC) allows since 2017 cancer patients at CHUV to have access to certain therapies, for which there are sufficient data suggesting a benefit in terms of quality of life. The concepts of tolerance, safety, risk of interactions and potential adverse biological effects remain central. Read More

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Fluorescent Silica Nanoparticles to Label Metastatic Tumor Cells in Mineralized Bone Microenvironments.

Small 2020 May 28:e2001432. Epub 2020 May 28.

Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.

During breast cancer bone metastasis, tumor cells interact with bone microenvironment components including inorganic minerals. Bone mineralization is a dynamic process and varies spatiotemporally as a function of cancer-promoting conditions such as age and diet. The functional relationship between skeletal dissemination of tumor cells and bone mineralization, however, is unclear. Read More

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http://dx.doi.org/10.1002/smll.202001432DOI Listing

Monensin inhibits proliferation, migration, and promotes apoptosis of breast cancer cells via downregulating UBA2.

Drug Dev Res 2020 May 27. Epub 2020 May 27.

Department of Thyroid and Breast Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.

Breast cancer is a malignant tumor that occurs in the epithelial tissue of the breast gland, the morbidity, and mortality of which continue to increase. Therefore, it is crucial to find new drugs to treat breast cancer. Monensin is a carrier antibiotic that has been reported to inhibit the growth of cancer cells; however, its impacts on breast cancer cells have not been reported. Read More

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http://dx.doi.org/10.1002/ddr.21683DOI Listing

Cancer mortality risk, fine particulate air pollution, and smoking in a large, representative cohort of US adults.

Cancer Causes Control 2020 May 27. Epub 2020 May 27.

Department of Economics, Brigham Young University, 142 FOB, Provo, UT, 84602, USA.

Purpose: Air pollution and smoking are associated with various types of mortality, including cancer. The current study utilizes a publicly accessible, nationally representative cohort to explore relationships between fine particulate matter (PM) exposure, smoking, and cancer mortality.

Methods: National Health Interview Survey and mortality follow-up data were combined to create a study population of 635,539 individuals surveyed from 1987 to 2014. Read More

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http://dx.doi.org/10.1007/s10552-020-01317-wDOI Listing

Association of polymorphisms in metastasis suppressor genes NME1 and KISS1 with breast cancer development and metastasis.

J Egypt Natl Canc Inst 2020 May 27;32(1):24. Epub 2020 May 27.

Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.

Background: NME1 and KISS1 genes are two tumor metastasis suppressor genes, mapped to chromosomes 17q21.3 and 1q32 respectively. Here, we analyzed the association of EcoR1 (rs34214448-G/T) polymorphism in NME1 gene and 9 del T (rs5780218-A/-) polymorphism in KISS1 gene with breast cancer development and metastasis. Read More

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http://dx.doi.org/10.1186/s43046-020-00037-1DOI Listing
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