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    447 results match your criteria Breast Disease [Journal]

    1 OF 9

    Overall survival of elderly patients with breast cancer is not related to breast-cancer specific survival: A single institution experience in Japan.
    Breast Dis 2018 Apr 5. Epub 2018 Apr 5.
    Background: As the aging population grows, the number of elderly breast cancer patients has rapidly increased especially in Japan; a suitable treatment for elderly patients, considering chronic comorbidities and treatment tolerance, is urgently needed.

    Methods: In this retrospective study, 286 elderly breast cancer patients were investigated. Tumor characteristics and survival outcome were compared between 70-79-year-old and ≥ 80-year-old groups. Read More

    The relationship between serum E2 levels and recurrence in premenopausal, ER-positive breast cancer patients: A retrospective study.
    Breast Dis 2018 Mar 19. Epub 2018 Mar 19.
    Department of Breast Surgery, The Tazuke Kofukai Medical Research Institute Kitano Hospital, 2-4-20 Ogi-machi Kita-ku Osaka, 530-8480 Japan.
    Background: Among estrogens, estradiol (E2) has the strongest physiological activity as a stimulator in estrogen receptor (ER)-positive breast cancer. The aim of this study is to investigate E2 dynamics during endocrine therapy and to explore the optimal environment in which tamoxifen (TAM) exhibits better efficacy for ER-positive premenopausal early breast cancer patients.

    Methods: This is a retrospective study enrolled 194 patients with premenopausal ER-positive early-stage breast cancer who aging ≤45 years at onset and receiving luteinizing hormone-releasing hormone-agonist (LHRH-a) and TAM-therapy. Read More

    Intracystic breast carcinoma. An important differential diagnosis in postmenopausal patients presenting with a rapidly growing breast cyst. Management and literature review.
    Breast Dis 2018 Mar 16. Epub 2018 Mar 16.
    Intracystic breast carcinoma is a rare clinical entity accounting for 0.5-2% of all breast cancers. It represents a distinctive clinical form rather a histological subtype of breast cancer and can either be in situ or invasive tumor. Read More

    Huge mucinous carcinoma of the breast in which doubling time was observed by computed tomography during 3 years without treatment.
    Breast Dis 2018 Mar 16. Epub 2018 Mar 16.
    Department of Surgery, Kashiwara City Municipal Hospital, 1-7-9 Hozenji, Kashiwara City, Osaka 582-0005, Japan.
    Here we report the case of a 77-year-old woman with a huge cancer of the right breast for which size was measured on computed tomography in our hospital preoperatively and in other hospital 3 years earlier. During the 3-year untreated interval, the tumor grew from 4 cm to 13 cm in maximum diameter, and the tumor-volume doubling time (TVDT) was calculated as 209 days. The patient underwent mastectomy with axillary lymph node dissection, with the large skin defect covered by autologous skin graft. Read More

    Forkhead box M1 (FOXM1) expression predicts disease free survival and may mediate resistance to chemotherapy and hormonotherapy in male breast cancer.
    Breast Dis 2018 ;37(3):109-114
    Department of Immuno-Histo-Cytology, Salah Azaïz Cancer Institute, Bab Saadoun, 1006 Tunis, Tunisia.
    Background: Male breast cancer (MBC) is a rare and neglected disease. Prognostic and predictive factors in MBC are extrapoled from trials conducted on its female counterpart.

    Objective: Since the relationship between the transcription factor Forkhead box M1 (FOXM1) expression and the clinical response to chemotherapy and hormonotherapy in MBC remains unknown, we sought to investigate the predictive value of FOXM1 in MBC. Read More

    Metaplastic carcinoma of the breast with mesenchymal differentiation (carcinosarcoma). A unique presentation of an aggressive malignancy and literature review.
    Breast Dis 2018 ;37(3):169-175
    Metaplastic carcinoma of the breast with mesenchymal differentiation (MCMD), previously known as carcinosarcoma, is a very rare and aggressive tumor that has been recently classified as a subtype of metaplastic breast carcinoma. It accounts for 0.08%-0. Read More

    Clinico-pathologic disparities of breast cancer in Hispanic/Latina women.
    Breast Dis 2018 ;37(3):147-154
    Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.
    Background: Breast cancer is the leading cause of cancer death in Hispanic/Latina women nationwide. Limited cancer research has been conducted in this population. El Paso, Texas is a large border city with a population of around 900,000, of which 85% are Latinos and would provide a suitable setting for this study. Read More

    Phyllodes tumors of the breast: clinicopathological analysis of 106 cases from a single institution.
    Breast Dis 2018 ;37(3):139-145
    Department of pathology, Hassan II university hospital, Fez, Morocco.
    Background: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. Read More

    Cytological diagnosis of crystallizing galactocele - report of an unusual case.
    Breast Dis 2018 ;37(3):159-161
    Crystallizing galactocele is a very rare entity which yields a viscous, chalky material on Fine Needle Aspiration Cytology (FNAC). FNAC is used both for diagnosis as well as treatment of this condition. We present here a case of 26 years old lactating female who presented with swelling in the right breast for 8 months. Read More

    Primary breast angiosarcoma - a single institution experience from a tertiary cancer center in South India.
    Breast Dis 2018 ;37(3):133-138
    Department of Pathology, Kidwai Cancer Institute, Bangalore, 560029, India.
    Introduction: Primary angiosarcoma of the breast is a rare entity with incidence of less than 0.05% of all malignant breast neoplasms. It occurs in young females without any associated risk factors. Read More

    First site of recurrence after breast cancer adjuvant treatment in the era of multimodality therapy: which imaging for which patient during follow-up?
    Breast Dis 2018 ;37(3):123-132
    University Tunis EI Manar Tunis, Faculty of Medicine, Medical Oncology Department, AbderrahmenMami Hospital, Ariana, Tunisia.
    Purpose: We evaluated the relation between first site of recurrence of early breast cancer and disease profile at presentation and reported survival results, suggesting a personalized diagnostic imaging guidance during follow up.

    Methods: Among 1400 early breast cancer treated from 2000 to 2010, 324 relapses were divided into 4 groups according to first site: A-locoregional, B-bone, C-Brain and D-visceral. We analyzed redictive factors of each group compared to a control group of 100 non relapsing patients and the remaining groups matched. Read More

    The enigma of granulomatous mastitis: A series.
    Breast Dis 2017 ;37(1):17-20
    Department of Plastic Surgery, Harlem Hospital Center, New York, NY, USA.
    Granulomatous mastitis is a chronic inflammatory breast disease with an enigmatic clinical presentation that can delay diagnosis and perpetuate ineffective treatments. We report our experience with the diagnosis and management of eighteen cases of granulomatous mastitis in the setting of an urban public hospital. The patients were identified after a retrospective review of pathology and surgery databases. Read More

    Follow-up of patients undergoing oncoplastic surgery - more palpable masses and benign biopsies.
    Breast Dis 2018 ;37(3):115-121
    Departments of Surgery, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
    Background: Oncoplastic reconstruction is increasingly used in the management of women undergoing breast conserving surgery. We examined the findings on breast exam and imaging of patients who underwent breast conservation with or without oncoplastic reconstruction.

    Objective: We hypothesized that patients undergoing immediate breast reconstruction would present with more palpable and imaging abnormalities compared to lumpectomy alone and undergo therefore more biopsies. Read More

    Analysis of patient-detected breast cancer recurrence.
    Breast Dis 2017 ;37(2):77-82
    Beth Israel Deaconess Medical Center/Harvard Medical School, Division of Surgical Oncology, Boston, MA, USA.
    Background: After primary surgical resection, breast cancer survivors regularly undergo surveillance using multiple modalities to detect recurrences.

    Objective: The goal of this study was to determine how breast cancer recurrences were detected in our sample population of breast cancer survivors. We hypothesize that the majority of recurrences are patient-detected. Read More

    Breast fibroadenoma with pseudoangiomatous (PASH-like) stroma.
    Breast Dis 2018 ;37(3):155-157
    Pseudoangiomatous stromal hyperplasia (PASH) is a breast stromal change, histologically characterized by anastomosing, slit-like spaces lined by slender myofibroblasts and surrounded by dense collagenous stroma. Mass forming cases clinically and radiologically simulate fibroadenoma. A middle aged women presented with unpalpable breast nodule discovered on ultrasound examination. Read More

    The importance of tattoo pigment in sentinel lymph nodes.
    Breast Dis 2017 ;37(2):73-76
    Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.
    Background: The presence of pigment in axillary lymph nodes (LN) secondary to migration of tattoo ink can imitate the appearance of a blue sentinel lymph node (SLN) on visual inspection, causing the operator to either miss the true SLN or excise more than is needed.

    Objective: We present patients with tattoos ipsilateral to an early stage breast cancer who underwent a SLN biopsy.

    Methods: Patients were retrospectively reviewed from medical records and clinicopathologic data was collected. Read More

    High-grade poorly differentiated neuroendocrine carcinoma of the breast with low oncotype Dx recurrence score: A case report.
    Breast Dis 2017 ;37(2):99-103
    Department of Pathology, Mercy Medical Center, Baltimore, MD, USA.
    Primary neuroendocrine carcinoma of the breast (NECB) is a rare malignant tumor with controversial biological behavior and a lack of data guiding treatment decisions due to its scarcity. Cancer gene-expression profiling tests provide a better indication of clinical prognosis and help determine the best clinical management versus the traditional clinical and pathological parameters. This is a report of a NECB with a genetic assay that showed a low-risk tumor despite high-grade and poorly differentiated histopathological features. Read More

    A rare benign tumor of breast masquerading on fine needle aspiration cytology: A case report.
    Breast Dis 2017 ;37(2):105-107
    Pleomorphic adenoma is a common tumor encountered in major salivary gland and very rarely seen in breast. This matrix producing tumor can be confused with fibroadenoma, phyllodes tumor and metaplastic carcinoma on fine needle aspiration cytology(FNAC). Pre-operative diagnosis of pleomorphic adenoma helps in preventing surgical over or under treatment of the disease. Read More

    Follow-up of granulomatous mastitis with monitoring versus surgery.
    Breast Dis 2017 ;37(2):69-72
    Background: IGM (Idiopathic Granulomatous Mastitis) is a rare, chronic, non-malignant and non-life-threatening breast disease. Clinically and radiologically, it has similar characteristics with other granulomatous diseases and breast carcinomas.

    Methods: The patients whom diagnosed IGM according to pathology report were retrospectively evaluated between November 2014 and January 2016. Read More

    Giant juvenile fibroadenoma in a 9-year-old: A case presentation and review of the current literature.
    Breast Dis 2017 ;37(2):95-98
    Department of Surgery, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USA.
    Juvenile fibroadenoma is the most common breast mass in adolescents accounting for 0.5-4% of all cases of fibroadenomas. Giant fibroadenomas are well-circumscribed, firm breast masses characterized by proliferation of epithelial and connective tissue. Read More

    The overall 5-year survival rate of breast cancer among Iranian women: A systematic review and meta-analysis of published studies.
    Breast Dis 2017 ;37(2):63-68
    Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
    Introduction: Breast Cancer (BC) is the most prevalent cancer and the second leading cause of cancer-related death among Iranian women. A valid estimation of the 5-year survival rate can improve the current BC treatment programs. The present study aimed to assess the 5-year survival rate through a systematic review of published studies. Read More

    Impaired expression of Drosha in breast cancer.
    Breast Dis 2017 ;37(2):55-62
    Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
    Background: Impaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy. We previously reported that DGCR8 and Dicer genes dysregulated in patients with breast cancer.

    Objective: To evaluate the expression pattern of Drosha in patients with breast cancer. Read More

    Gigantomastia due to retromammary lipoma: An aesthetic management.
    Breast Dis 2017 ;37(1):33-37
    Department of Plastic Surgery, R.G.Kar Medical College, Kolkata.
    Introduction: A "giant" lipoma is defined as a tumor having dimensions greater than 10 cm. Giant lipomas are rare and giant breast lipomas are exceptionally uncommon. Only six cases have been described in world literature till date. Read More

    Expression analysis of long non-coding ATB and its putative target in breast cancer.
    Breast Dis 2017 ;37(1):11-20
    Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) has been recently shown to promote the invasion-metastasis cascade in various types of cancers via upregulation of some targets including ZEB1.

    Objectives: The aim of the present study was to elucidate the expression of lncRNA-ATB and ZEB in breast cancer patients.

    Methods: The expression of these genes was evaluated by real-time reverse transcription polymerase chain reaction in tumor samples form 50 newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ANCTs). Read More

    The evaluation of the effect of metformin on breast fibrocystic disease.
    Breast Dis 2017 ;37(2):49-53
    Background: Fibrocystic changes (FCC) is the most common benign breast disease. The main pathophysiologic mechanism of FCC, excessive cell proliferation in response to monthly estrogen and progesterone changes. Regarding to antiproliferative of metformin, the aim of this study is the evaluation of the effect of metformin on FCC in women who were referred to gynecology clinics of ArakMETHODS:This study is a double blind placebo control randomized clinical trial. Read More

    Retinoic acid-related orphan receptor alpha (RORA) variants and risk of breast cancer.
    Breast Dis 2017 ;37(1):21-25
    Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Background: Breast cancer is the most common type of cancer and the second leading cause of cancer death in females. Despite numerous studies in this field, the etiology and clinical behavior of breast tumors have not been understood yet. Retinoid orphan nuclear receptor alpha (RORA) is a member of the orphan nuclear factor family involved in the regulation of lipid and steroid metabolism, immune response and circadian rhythms. Read More

    Huge lactating adenoma of the breast: Case report.
    Breast Dis 2017 ;37(1):37-42
    Assistant lecturer of surgical oncology, Oncology center Mansoura University, Mansoura, Egypt.
    Introduction: Lactating adenoma is the commonest benign breast lesion seen during pregnancy and puerperium. It is commonly seen in young primigravideous women in the second or third decade during the third trimester of their pregnancy. Occasionally, lactating adenoma is large and rapidly growing and must be differentiated from malignant breast masses that could be seen during pregnancy and lactation. Read More

    Synchronous and metachronous breast cancer in Ukraine.
    Breast Dis 2017 ;37(2):83-93
    Oncology Department Bogomolets National Medical University, 03022, Kyiv, Ukraine.
    Aim: This study aims to describe the current state of multiple primary malignant neoplasms (MPMNs) breast cancer patients management, evaluate the predictive impact of different factors, optimise approaches to diagnosis and treatment of these patients and improve their life quality.

    Methods: The study included 2,032 patients who received special treatment at the Department of Breast Tumours and it Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 within an open randomized controlled trial. The sample included 195 patients with synchronous cancer or metachronous breast cancer. Read More

    Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in non-metastatic breast cancer patients from a Hispanic population.
    Breast Dis 2017 ;37(1):1-6
    Departamento de Patología, Hospital San Juan de Dios, San José, Costa Rica.
    Background: High values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been associated with poor prognosis in certain tumors. Nevertheless, few data exist regarding these prognostic variables in breast cancer patients from Hispanic populations. In this study, we aimed to determine the prognostic value of these two estimates and to establish the best cutoff to categorize patients according to their risk. Read More

    A rare case of umbilical metastasis after delayed transverse rectus abdominis myocutaneous flap reconstruction for invasive breast cancer.
    Breast Dis 2017 ;37(1):33-35
    A 46-year-old female presented with an inflamed and painful umbilicus. Past medical history included breast cancer, followed by metastatic sternal cancer two years after the initial breast cancer diagnosis.The painful umbilicus was confirmed metastasis from a primary breast cancer she had treated eleven years previously. Read More

    Expression of TTF-1 in breast cancer independently of ER expression: A case report and pathogenic implications.
    Breast Dis 2017 ;37(1):1-6
    Department of Pathology, Sault Area Hospital, Sault Ste Marie, ON, Canada.
    Thyroid Transcription Factor 1 (TTF-1) is often used for the immunohistochemical evaluation of lung cancers, as a significant proportion of these cancers are positive while other adenocarcinomas are usually negative. Breast cancers are known to express TTF-1 only in a small minority of cases but this may be problematic when this staining is used for its differential diagnosis from lung cancer. We present a case of ER-positive breast cancer in 30% of tumor cells that was also TTF-1 positive in some areas of the primary tumor but lost ER expression completely in the metastatic recurrence site while retaining TTF-1 positivity. Read More

    Breast cancer brain metastases: Molecular subtype, treatment and survival.
    Breast Dis 2016 ;36(4):133-141
    Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.
    Background: No clear guidelines exist for management of breast cancer brain metastases (BCBM).

    Objective: We assessed the relationship between patient and tumor characteristics, treatment, and overall survival (OS).

    Methods: We conducted a retrospective review of 196 patients who received brain radiation for BCBM between 2009-2013 at Mayo Clinic. Read More

    A case of multicentric low-grade neuroendocrine breast tumor with an unusual histological pattern.
    Breast Dis 2016 ;36(4):161-164
    Breast Unit, Salerno, Italy, A.O.U. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy.
    Neuroendocrine features are detectable in carcinomas of the breast either as scattered cells, that are recognized by their expression of neuroendocrine cell markers. Instead, pure breast carcinomas with neuroendocrine features (NEBC) are very rare and represent <1% of all breast cancer. Usually NEBC may be well or poorly differentiated and more frequent in older woman. Read More

    Evaluation of efficacy of thermographic breast imaging in breast cancer: A pilot study.
    Breast Dis 2016 ;36(4):143-147
    Xerox Research Centre India, Bangalore, India.
    Background: Thermographic imaging is a non-invasive and radiation free imaging modality that measures the infrared radiation released by the body. Recently, there is a renewed interest regarding the scope of thermal imaging for breast cancer.

    Objective: To evaluate the efficacy of thermographic breast imaging in detecting breast cancer. Read More

    Crystallizing galactocele: Report of a rare variation.
    Breast Dis 2016 Jul;36(2-3):111-4
    The physiological changes of the breast during pregnancy and lactation make the clinical, radiological and pathological evaluation of a breast mass challenging. Galactoceles are benign lesions containing milk, and generally occur post partum. Fine needle aspiration cytology is a simple, quick and effective technique for the diagnosis of the same during this period, and in case of galactocele the same can be both diagnostic and therapeutic. Read More

    Alcohol consumption and mortality after breast cancer diagnosis: The health and functioning in women study.
    Breast Dis 2016 Jul;36(2-3):77-89
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
    Objective: To determine the association of prediagnostic alcohol consumption with long-term mortality from breast cancer and other causes in a cohort of women with breast cancer.

    Methods: We studied a Michigan-based cohort of 939 women aged 40-84 years, who provided complete information about the type, amount and intensity of prediagnostic alcohol consumption. Associations of alcohol consumption, based on weekly volume of alcohol consumption during the year prior to breast cancer diagnosis, with mortality were evaluated in Cox proportional hazards models, with adjustment for sociodemographic factors, body mass index, smoking, comorbidity, tumor characteristics, and treatment. Read More

    Bioimpedance to screen for abdominal fat in patients with breast cancer treatment-related lymphedema.
    Breast Dis 2016 Jul;36(2-3):73-6
    Cardiovascular Surgery Department, Medicine School, Sao Jose do Rio Preto (FAMERP), Brazil.
    Background: One of the dreaded complications after the treatment of breast cancer is lymphedema. Therapies used in the treatment of breast cancer such as surgery, radiotherapy, hormone therapy and chemotherapy may be adversely affected by obesity.

    Aim: The objective of this study was to use bioimpedance to assess abdominal fat in women with breast cancer treatment-related lymphedema and suggest this as a screening method. Read More

    The impact of Oncotype DX® recurrence score of paraffin-embedded core biopsy tissues in predicting response to neoadjuvant chemotherapy in women with breast cancer.
    Breast Dis 2016 Jul;36(2-3):65-71
    Department of Surgery, Division of Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA.
    Background: Oncotype DX® test is beneficial in predicting recurrence free survival in estrogen receptor positive (ER+) breast cancer. Ability of the assay to predict response to neoadjuvant chemotherapy (NCT) is less well-studied.

    Objective: We hypothesize a positive association between the Oncotype DX® recurrence score (RS) and the percentage tumor response (%TR) after NCT. Read More

    Etiologic revelation and outcome of the surgical management of idiopathic granulomatous mastitis; An Egyptian centre experience.
    Breast Dis 2016 ;36(4):115-122
    Introduction: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory condition that is confused with cancer. It usually affects women in child bearing age. The exact aetiology and pathogenesis are still unknown, and the optimal therapeutic modality has not yet been established. Read More

    Correlation between the DNA methylation and gene expression of IGFBP5 in breast cancer.
    Breast Dis 2016 ;36(4):123-131
    Marmara University, School of Medicine, Medical Biology Department, Istanbul, Turkey.
    Background: The insulin-like growth factor binding protein5 (IGFBP5) is often dysregulated in human cancers and considered neither a tumor suppressor nor an oncogene.

    Objective: We aim to examine the reason of the changeable gene regulation of IGFBP5 in the case of methylation in breast cancer.

    Methods: We used methyl-specific polymerase (MSP) chain reaction to detect CpG methylation of IGFBP5 promoter and exon-I in breast cancer and adjacent tissues. Read More

    Desmoid-type fibromatosis of the breast: A case report.
    Breast Dis 2016 ;36(4):149-152
    Desmoid-type fibromatosis of the breast (also referred to as desmoid tumor or aggressive fibromatosis) is exceedingly rare. Although it does not metastasize, desmoid-type fibromatosisis is frequently locally aggressive. Recurrence is common (up to 35%), even after presumed total excision of the primary tumor [1]. Read More

    Incidental unilateral and bilateral ductal carcinoma in situ encountered in the surgical management of young male gynecomastia.
    Breast Dis 2016 Jul;36(2-3):103-10
    Department of General Surgery, Al Ansar General Hospital, Medina, Saudi Arabia.
    Background: The increased risk for malignant tumors associated with male gynecomastia has been well established and many authors have reported cases of concurrent gynecomastia and ductal carcinoma in situ (DCIS) in the same breast. Synchronous bilateral breast cancer in association with gynecomastia is exceptionally rare. We aim to report and evaluate the management outcome of 5 cases of gynecomastia associated with DCIS (1 bilateral and 4 unilateral). Read More

    Sunitinib alone or in combination with chemotherapy for the treatment of advanced breast cancer: A systematic review and meta-analysis.
    Breast Dis 2016 Jul;36(2-3):91-101
    Medical Research Group of Egypt, Egypt.
    Introduction: Sunitinib is an orally delivered tyrosine kinase inhibitor that exhibits antiangiogenic effects. FDA has approved sunitinib for the treatment of metastatic renal cell carcinoma. However, its efficacy for the treatment of advanced breast cancer (ABC) remains controversial. Read More

    Fibroadenoma with "immature-like" type of usual ductal hyperplasia.
    Breast Dis 2016 ;36(4):157-160
    We herein report a case of the breast fibroadenoma with foci of so-called immature variant of the conventional ductal hyperplasia. This type of usual ductal hyperplasia is histologically characterised by encircling intraductal proliferation of large cells with pale to amphophilic cytoplasm and large nuclei which vary in shape and in staining quality of the chromatin. We showed here, using the cytokeratin immunohistochemistry, that the proliferating cells were not of immature but rather mature immunohistochemical phenotype. Read More

    Malignant phyllodes tumor in an 11-year-old girl with fatal clinical outcome. A case report.
    Breast Dis 2016 Jan;36(1):61-4
    Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.
    Background: Phyllodes tumors are rare biphasic tumors occur predominantly in middle aged women. Malignant phyllodes tumor in children is very rare.

    Objective: To report a case of malignant phyllodes tumor in a pre-menarchal girl. Read More

    Envisioning metastasis as a transdifferentiation phenomenon clarifies discordant results on cancer.
    Breast Dis 2016 Feb;36(1):47-59
    Cancer is generally conceived as a dedifferentiation process in which quiescent post-mitotic differentiated cells acquire stem-like properties and the capacity to proliferate. This view holds for the initial stages of carcinogenesis but is more questionable for advanced stages when the cells can transdifferentiate into the contractile phenotype associated to migration and metastasis. Singularly from this perspective, the hallmark of the most aggressive cancers would correspond to a genuine differentiation status, even if it is different from the original one. Read More

    Evaluation of therapeutic mammoplasty techniques in the surgical management of female patients with idiopathic granulomatous mastitis with mild to moderate inflammatory symptoms in terms of recurrence and patients' satisfaction.
    Breast Dis 2016 Feb;36(1):37-45
    Department of General Surgery, Faculty of Medicine, University of Alexandria, Egypt.
    Background: Although idiopathic granulomatous mastitis (IGM) affects young females, its surgical management usually leads to disfigurement of the breasts.

    Objectives: To assess the use of therapeutic mammoplasty techniques for management of IGM in terms of recurrence and postoperative patients' satisfaction.

    Methods: This prospective clinical study included thirteen patients who were diagnosed histologically as IGM. Read More

    Enhancing patterns of breast cancer on preoperative dynamic contrast-enhanced magnetic resonance imaging and resection margin in breast conserving therapy.
    Breast Dis 2016 Feb;36(1):27-35
    Department of Surgery, Haeundae Paik Hospital, College of Medicine, Inje University, Busan, Korea.
    Background: The association between enhancing patterns of preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and resection margins after BCS has not been studied in detail before.

    Objective: We investigated the association between surgical outcomes and enhancing patterns observed on DCE-MRI.

    Methods: 269 enhancing patterns on DCE-MRI scans were selected, and subdivided into the following groups: (1) a single mass-like enhancement, (2) a single non-mass-like enhancement (NME), (3) mass-like enhancing breast cancer with other mass-like enhancing lesions, and (4) mass-like enhancing breast cancer with additional NMEs. Read More

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