463 results match your criteria Breast Disease [Journal]


Upstaging papillary lesions to carcinoma on surgical excision is not impacted by patient race.

Breast Dis 2019 Apr 10. Epub 2019 Apr 10.

Division of Surgical Pathology, Mercy Hospital and Medical Center, 2525 Michigan Avenue, Chicago, IL, USA.

Background: The management of papillary lesions is controversial with studies showing different rates of upstaging to malignancy. There is a paucity of research into race as an independent risk factor. The aim of this study is to identify if race is correlated with upstaging to malignancy with a secondary focus of analyzing for other personal and tumor specific risk factors for upstaging. Read More

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http://dx.doi.org/10.3233/BD-180379DOI Listing
April 2019
1 Read

Oncology nurses' knowledge about Lymphedema Assessment, Prevention, and Management among Women with Breast Cancer.

Authors:
Loai Abu Sharour

Breast Dis 2019 Mar 26. Epub 2019 Mar 26.

Faculty of Nursing, AL-Zaytoonah University of Jordan, P.O. Box 130, Amman 11733, Jordan.

Background: Breast cancer-related lymphedema (BCRL) is one of the most common complications among women with breast cancer.

Objective: This study was conducted to evaluate the oncology nurses' knowledge about lymphedema assessment, prevention, and management among women with breast cancer, and identify the relationships between oncology nurses' academic qualification, years of experience, and level of knowledge.

Methods: A cross-sectional descriptive design was used. Read More

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http://dx.doi.org/10.3233/BD-190381DOI Listing
March 2019
1 Read

WITHDRAWN: Performance of survivin mRNA as a biomarker for breast cancer among Vietnamese women.

Breast Dis 2019 Mar 26. Epub 2019 Mar 26.

Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi, Vietnam.

Ahead of Print article withdrawn by publisher. Read More

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http://dx.doi.org/10.3233/BD-180374DOI Listing

Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis.

Breast Dis 2019 Apr 1. Epub 2019 Apr 1.

Department of Pathology, General Hospital Slavonski Brod, Croatia.

Background: Proliferation rate is a major determinant of the biologic behavior of the tumor and provides information that can be used to guide treatment decisions.

Methods: This ring study included 27 pathologists from 14 Institutions, in order to assess inter-observer concordance between pathologists in Croatia. We analyzed Ki-67 proliferative index on ten randomly selected breast cancer samples comparing consistency between visual assessment using light microscopy compared to digital image analyses results from one central laboratory as a referral value. Read More

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http://dx.doi.org/10.3233/BD-180341DOI Listing

A clinicopathological study of fibroadenomas with epithelial proliferation including lobular carcinoma in-situ, atypical ductal hyperplasia, DCIS and invasive carcinoma.

Breast Dis 2019 Mar 22. Epub 2019 Mar 22.

Arkadi Rywlin Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami, Florida, USA.

Background: Fibroadenoma is a benign mixed tumor composed of epithelial and non-epithelial components. The epithelial component of a fibroadenoma may exhibit proliferation, including lobular carcinoma in-situ, atypical ductal hyperplasia, DCIS and rarely, invasive breast carcinoma.

Objectuve: In this series of 30 cases of fibroadenoma with epithelial proliferation, we assessed the radiological and histopathological findings of each entity. Read More

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http://dx.doi.org/10.3233/BD-180368DOI Listing
March 2019
4 Reads

A comparative analysis of axillary nodal burden in ultrasound/biopsy positive axilla vs ultrasound negative sentinel lymph node biopsy positive axilla.

Breast Dis 2019 Mar 22. Epub 2019 Mar 22.

Breast Unit, University Hospital of North Midlands and Keele University, Stoke On Trent, UK.

Background: Axillary Ultrasound (AUS) is now performed as a protocol in every newly diagnosed breast cancer in most European countries. It is an inexpensive and sensitive tool in hands of a trained operator. All AUS negative patients undergo Sentinel Lymph Node Biopsy (SLNB), while AUS positive patients bypass SLNB and undergo axillary nodal clearance (ANC) as a standard protocol. Read More

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http://dx.doi.org/10.3233/BD-160230DOI Listing
March 2019
7 Reads

Metastatic breast cancer to the adductor magnus: A case report and literature overview.

Breast Dis 2019 ;38(1):35-38

University of Illinois, Chicago, USA.

Metastatic breast cancer is commonly found in the pectoralis major and minor muscles, ribs, spine, pelvis, long bones of the extremities, liver, lung, and the brain. It is unusual to see breast cancer metastases to distal skeletal muscle. We report a case of a patient with a history of stage IIA infiltrating lobular carcinoma of the right breast presenting with a metastatic lesion in the right adductor magnus. Read More

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http://dx.doi.org/10.3233/BD-180376DOI Listing
January 2019
1 Read

Breast cancer section analysis correlates with sentinel lymph node biopsies: Precision and topographic anatomy.

Breast Dis 2019 ;38(1):1-5

Department of 1st Propaedeutic Surgery, University of Athens, Medical School, Hippokratio Hospital, Athens, Greece.

Background: The mainstream treatment of breast cancer is radical mastectomy accompanied with Axillary Lymph Node Dissection (ALND). Lately, more conservative methods accompanied by adjuvant radiotherapy have been gradually replacing radical modalities. The Sentinel Lymph Node Biopsy (SLNB) has been considered such a valuable alternative to surgery conservative approach. Read More

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http://dx.doi.org/10.3233/BD-180355DOI Listing
January 2019
2 Reads

DSCAM-AS1 up-regulation in invasive ductal carcinoma of breast and assessment of its potential as a diagnostic biomarker.

Breast Dis 2019 ;38(1):25-30

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The long non-coding RNA (lncRNA) DSCAM-AS1 has been demonstrated to participate in the pathogenesis of breast cancer and tamoxifen resistance.

Objective: To evaluate expression profile of DSCAM-AS1 in invasive ductal carcinoma of breast and its suitability as a biomarker for diagnosis of breast cancer.

Methods: We evaluated expression of DSCAM-AS1 in 108 breast tissues including tumoral and adjacent non-cancerous tissues (ANCTs) by means of quantitative real time PCR. Read More

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http://dx.doi.org/10.3233/BD-180351DOI Listing
January 2019
1 Read

Expression of urokinase plasminogen activator (uPA) in the leukocytes and tissues of patients with benign and malignant breast lesions.

Breast Dis 2019 ;38(1):15-23

Institute of Oncology of Southern Switzerland (IOSI), Breast Unit of Southern Switzerland (CSSI), 6500, Bellinzona, Ticino, Switzerland.

Objective: To show that the expression of urokinase plasminogen activator (uPA) in the leucocytes of patients with benign and malignant breast lesions correlates with its expression in the lesions, and to explore the role of uPA as a tumour marker in breast cancer.

Methods: Using real time reverse transcriptase - polymerase chain reaction (RT-PCR), we examined the expression of uPA in leukocytes and tissues of three groups of women: a) with breast cancer (BC), b) with benign breast lesions and c) a control group of healthy women. An arbitrary value of 1 was assigned to the level of uPA expressed in the leucocytes of the healthy controls; all other measurements were expressed as a function of this value. Read More

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http://dx.doi.org/10.3233/BD-180348DOI Listing
January 2019
2 Reads

Recurrent Mondor's breast disease -- Hormonal contraceptive involvement.

Breast Dis 2019 ;38(1):31-33

Department of Gynecology, Geneva University hospitals (HUG), Switzerland.

Mondor's disease can be a challenging diagnosis. The case we present is of a 29 year-old Brazilian woman, under combined hormonal contraception, who consulted for a painful lump on her right breast. She presented a complete resolution after a local treatment of heparinoid cream and a non-steroidal anti-inflammatory oral treatment, but relapsed 18 months later. Read More

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http://dx.doi.org/10.3233/BD-180346DOI Listing
January 2019
3 Reads

Re-excision rate after sector resection for breast cancer: A 5-year retrospective cohort study.

Breast Dis 2019 ;38(1):7-13

Breast and Endocrine Surgery Unit, Flinders Medical Centre, Adelaide, Australia.

Background: Positive margins after Breast conserving surgery (BCS) for breast cancer can result in local recurrence (LR) requiring further surgery. This can lead to unnecessary patient anxiety, poor prognosis and impose additional economic burden to our health system. The aim of this study is to assess the rate of re-excision for positive margins after BCS using the sector resection technique. Read More

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http://dx.doi.org/10.3233/BD-180339DOI Listing
January 2019
17 Reads

Role of radiotherapy in women over the age of 65 after breast conserving surgery for breast cancer: A 5-year retrospective study.

Breast Dis 2018 ;37(4):197-205

Department of Surgery, Flinders University School of Medicine, Adelaide, SA, Australia.

Background/objective: This study aimed to analyse the local recurrence (LR) and breast cancer related mortality (BCRM) in older women who underwent breast-conserving surgery (BCS) with and without adjuvant radiotherapy (XRT).

Methods: This retrospective study included a total of 299 women who underwent BCS for early breast carcinoma, between the years of 2007 and 2011. Predictive risk factors, local recurrence (LR) and breast cancer related mortality (BCRM) were assessed with a mean follow-up period of 84 months. Read More

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http://dx.doi.org/10.3233/BD-180340DOI Listing
April 2019
12 Reads

Molecular prevalence of human papillomavirus infection among Iranian women with breast cancer.

Breast Dis 2018 ;37(4):207-213

Department of Virology, Iran University of Medical Sciences, Tehran, Iran.

Background: The etiology and molecular mechanisms involved in the development of breast cancer still remain poorly understood. Some epidemiological studies have shown an association between human papillomavirus (HPV) and breast cancer. However, the findings are controversial. Read More

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http://dx.doi.org/10.3233/BD-180333DOI Listing
April 2019
1 Read

Ductal carcinoma in-situ, cystic hypersecretory type presented by recurrent hemorrhagic cyst.

Breast Dis 2018 ;37(4):225-227

Queen Sirikit Centre for Breast Cancer, Thai Red Cross Society, Bangkok, Thailand.

Recurrent hemorrhagic cyst is an uncommon presentation of breast disease. The ordinary imaging could not demonstrate the malignant features of the cyst. However, the non-contrast dedicated breast computerized tomography could support the malignancy concern. Read More

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http://dx.doi.org/10.3233/BD-180328DOI Listing
April 2019
18 Reads

Prospective comparative study assessing role of ultrasound versus thermography in breast cancer detection.

Breast Dis 2018 ;37(4):191-196

Department of Bio-Medical Engineering, Institute of Electrical Engineering & Information Technology, Iranian Research Organization for Science and Technology (IROST), Tehran, Iran.

Background: The limitations of mammography as a screening and diagnostic tool, especially for younger women with dense breasts, makes it necessary to use an adjunctive modality to cover its shortcomings. Ultrasound and thermography both have potential role in this era.

Objectives: We will compare the accuracy of thermography with ultrasound in breast cancer diagnosis in a clinical setting. Read More

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http://dx.doi.org/10.3233/BD-180321DOI Listing
April 2019
2 Reads

Overall survival of elderly patients with breast cancer is not related to breast-cancer specific survival: A single institution experience in Japan.

Breast Dis 2018 ;37(4):177-183

Background: As the aging population grows, the number of elderly breast cancer patients has rapidly increased especially in Japan; a suitable treatment for elderly patients, considering chronic comorbidities and treatment tolerance, is urgently needed.

Methods: In this retrospective study, 286 elderly breast cancer patients were investigated. Tumor characteristics and survival outcome were compared between 70-79-year-old and ≥ 80-year-old groups. Read More

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http://dx.doi.org/10.3233/BD-170280DOI Listing
April 2019
6 Reads

The relationship between serum E2 levels and recurrence in premenopausal, ER-positive breast cancer patients: A retrospective study.

Breast Dis 2018 ;37(4):185-190

Department of Breast Surgery, The Tazuke Kofukai Medical Research Institute Kitano Hospital, 2-4-20 Ogi-machi Kita-ku Osaka, 530-8480 Japan.

Background: Among estrogens, estradiol (E2) has the strongest physiological activity as a stimulator in estrogen receptor (ER)-positive breast cancer. The aim of this study is to investigate E2 dynamics during endocrine therapy and to explore the optimal environment in which tamoxifen (TAM) exhibits better efficacy for ER-positive premenopausal early breast cancer patients.

Methods: This is a retrospective study enrolled 194 patients with premenopausal ER-positive early-stage breast cancer who aging ≤45 years at onset and receiving luteinizing hormone-releasing hormone-agonist (LHRH-a) and TAM-therapy. Read More

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http://dx.doi.org/10.3233/BD-170307DOI Listing
April 2019
10 Reads

Intracystic breast carcinoma. An important differential diagnosis in postmenopausal patients presenting with a rapidly growing breast cyst. Management and literature review.

Breast Dis 2018 ;37(4):219-224

Intracystic breast carcinoma is a rare clinical entity accounting for 0.5-2% of all breast cancers. It represents a distinctive clinical form rather a histological subtype of breast cancer and can either be in situ or invasive tumor. Read More

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http://dx.doi.org/10.3233/BD-170316DOI Listing
April 2019
4 Reads

Huge mucinous carcinoma of the breast in which doubling time was observed by computed tomography during 3 years without treatment.

Breast Dis 2018 ;37(4):215-218

Department of Surgery, Kashiwara City Municipal Hospital, 1-7-9 Hozenji, Kashiwara City, Osaka 582-0005, Japan.

Here we report the case of a 77-year-old woman with a huge cancer of the right breast for which size was measured on computed tomography in our hospital preoperatively and in other hospital 3 years earlier. During the 3-year untreated interval, the tumor grew from 4 cm to 13 cm in maximum diameter, and the tumor-volume doubling time (TVDT) was calculated as 209 days. The patient underwent mastectomy with axillary lymph node dissection, with the large skin defect covered by autologous skin graft. Read More

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http://dx.doi.org/10.3233/BD-170300DOI Listing
April 2019
5 Reads

Forkhead box M1 (FOXM1) expression predicts disease free survival and may mediate resistance to chemotherapy and hormonotherapy in male breast cancer.

Breast Dis 2018 ;37(3):109-114

Department of Immuno-Histo-Cytology, Salah Azaïz Cancer Institute, Bab Saadoun, 1006 Tunis, Tunisia.

Background: Male breast cancer (MBC) is a rare and neglected disease. Prognostic and predictive factors in MBC are extrapoled from trials conducted on its female counterpart.

Objective: Since the relationship between the transcription factor Forkhead box M1 (FOXM1) expression and the clinical response to chemotherapy and hormonotherapy in MBC remains unknown, we sought to investigate the predictive value of FOXM1 in MBC. Read More

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http://dx.doi.org/10.3233/BD-170315DOI Listing
September 2018
24 Reads

Metaplastic carcinoma of the breast with mesenchymal differentiation (carcinosarcoma). A unique presentation of an aggressive malignancy and literature review.

Breast Dis 2018 ;37(3):169-175

Metaplastic carcinoma of the breast with mesenchymal differentiation (MCMD), previously known as carcinosarcoma, is a very rare and aggressive tumor that has been recently classified as a subtype of metaplastic breast carcinoma. It accounts for 0.08%-0. Read More

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http://dx.doi.org/10.3233/BD-170313DOI Listing
September 2018
18 Reads

Clinico-pathologic disparities of breast cancer in Hispanic/Latina women.

Breast Dis 2018 ;37(3):147-154

Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Breast cancer is the leading cause of cancer death in Hispanic/Latina women nationwide. Limited cancer research has been conducted in this population. El Paso, Texas is a large border city with a population of around 900,000, of which 85% are Latinos and would provide a suitable setting for this study. Read More

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http://dx.doi.org/10.3233/BD-170309DOI Listing
September 2018
18 Reads

Isolated metachronous breast metastasis from renal cell carcinoma: A report of two cases.

Breast Dis 2018 ;37(3):163-167

Metastases to the breast are very uncommon as compared to primary tumours. Breast is an unusual site for metastasis from renal cell carcinoma. Only occasional cases are reported in the literature. Read More

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http://dx.doi.org/10.3233/BD-170294DOI Listing
September 2018
7 Reads

Phyllodes tumors of the breast: clinicopathological analysis of 106 cases from a single institution.

Breast Dis 2018 ;37(3):139-145

Department of pathology, Hassan II university hospital, Fez, Morocco.

Background: Phyllodes tumors (PT) are uncommon biphasic tumors, accounting for less than 1% of all breast primary neoplasms. They form a wide variety of tumors ranging from benign to malignant. Several histological features are used to grade PT into 3 categories: benign (grade I), borderline (grade II) and malignant (grade III) tumors. Read More

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http://dx.doi.org/10.3233/BD-170297DOI Listing
September 2018
13 Reads

Cytological diagnosis of crystallizing galactocele - report of an unusual case.

Breast Dis 2018 ;37(3):159-161

Crystallizing galactocele is a very rare entity which yields a viscous, chalky material on Fine Needle Aspiration Cytology (FNAC). FNAC is used both for diagnosis as well as treatment of this condition. We present here a case of 26 years old lactating female who presented with swelling in the right breast for 8 months. Read More

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http://dx.doi.org/10.3233/BD-170295DOI Listing
September 2018
9 Reads

Primary breast angiosarcoma - a single institution experience from a tertiary cancer center in South India.

Breast Dis 2018 ;37(3):133-138

Department of Pathology, Kidwai Cancer Institute, Bangalore, 560029, India.

Introduction: Primary angiosarcoma of the breast is a rare entity with incidence of less than 0.05% of all malignant breast neoplasms. It occurs in young females without any associated risk factors. Read More

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http://dx.doi.org/10.3233/BD-170291DOI Listing
September 2018
22 Reads

First site of recurrence after breast cancer adjuvant treatment in the era of multimodality therapy: which imaging for which patient during follow-up?

Breast Dis 2018 ;37(3):123-132

University Tunis EI Manar Tunis, Faculty of Medicine, Medical Oncology Department, AbderrahmenMami Hospital, Ariana, Tunisia.

Purpose: We evaluated the relation between first site of recurrence of early breast cancer and disease profile at presentation and reported survival results, suggesting a personalized diagnostic imaging guidance during follow up.

Methods: Among 1400 early breast cancer treated from 2000 to 2010, 324 relapses were divided into 4 groups according to first site: A-locoregional, B-bone, C-Brain and D-visceral. We analyzed redictive factors of each group compared to a control group of 100 non relapsing patients and the remaining groups matched. Read More

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http://dx.doi.org/10.3233/BD-170290DOI Listing
September 2018
31 Reads

The enigma of granulomatous mastitis: A series.

Breast Dis 2017 ;37(1):17-20

Department of Plastic Surgery, Harlem Hospital Center, New York, NY, USA.

Granulomatous mastitis is a chronic inflammatory breast disease with an enigmatic clinical presentation that can delay diagnosis and perpetuate ineffective treatments. We report our experience with the diagnosis and management of eighteen cases of granulomatous mastitis in the setting of an urban public hospital. The patients were identified after a retrospective review of pathology and surgery databases. Read More

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http://dx.doi.org/10.3233/BD-160261DOI Listing
August 2018
16 Reads

Follow-up of patients undergoing oncoplastic surgery - more palpable masses and benign biopsies.

Breast Dis 2018 ;37(3):115-121

Departments of Surgery, Tel-Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.

Background: Oncoplastic reconstruction is increasingly used in the management of women undergoing breast conserving surgery. We examined the findings on breast exam and imaging of patients who underwent breast conservation with or without oncoplastic reconstruction.

Objective: We hypothesized that patients undergoing immediate breast reconstruction would present with more palpable and imaging abnormalities compared to lumpectomy alone and undergo therefore more biopsies. Read More

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http://dx.doi.org/10.3233/BD-170284DOI Listing
September 2018
24 Reads

Analysis of patient-detected breast cancer recurrence.

Breast Dis 2017 ;37(2):77-82

Beth Israel Deaconess Medical Center/Harvard Medical School, Division of Surgical Oncology, Boston, MA, USA.

Background: After primary surgical resection, breast cancer survivors regularly undergo surveillance using multiple modalities to detect recurrences.

Objective: The goal of this study was to determine how breast cancer recurrences were detected in our sample population of breast cancer survivors. We hypothesize that the majority of recurrences are patient-detected. Read More

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http://dx.doi.org/10.3233/BD-170288DOI Listing
September 2018
12 Reads

Breast fibroadenoma with pseudoangiomatous (PASH-like) stroma.

Breast Dis 2018 ;37(3):155-157

Pseudoangiomatous stromal hyperplasia (PASH) is a breast stromal change, histologically characterized by anastomosing, slit-like spaces lined by slender myofibroblasts and surrounded by dense collagenous stroma. Mass forming cases clinically and radiologically simulate fibroadenoma. A middle aged women presented with unpalpable breast nodule discovered on ultrasound examination. Read More

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http://dx.doi.org/10.3233/BD-170281DOI Listing
September 2018
13 Reads

The importance of tattoo pigment in sentinel lymph nodes.

Breast Dis 2017 ;37(2):73-76

Division of Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA.

Background: The presence of pigment in axillary lymph nodes (LN) secondary to migration of tattoo ink can imitate the appearance of a blue sentinel lymph node (SLN) on visual inspection, causing the operator to either miss the true SLN or excise more than is needed.

Objective: We present patients with tattoos ipsilateral to an early stage breast cancer who underwent a SLN biopsy.

Methods: Patients were retrospectively reviewed from medical records and clinicopathologic data was collected. Read More

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http://dx.doi.org/10.3233/BD-170282DOI Listing
September 2018
43 Reads

High-grade poorly differentiated neuroendocrine carcinoma of the breast with low oncotype Dx recurrence score: A case report.

Breast Dis 2017 ;37(2):99-103

Department of Pathology, Mercy Medical Center, Baltimore, MD, USA.

Primary neuroendocrine carcinoma of the breast (NECB) is a rare malignant tumor with controversial biological behavior and a lack of data guiding treatment decisions due to its scarcity. Cancer gene-expression profiling tests provide a better indication of clinical prognosis and help determine the best clinical management versus the traditional clinical and pathological parameters. This is a report of a NECB with a genetic assay that showed a low-risk tumor despite high-grade and poorly differentiated histopathological features. Read More

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http://dx.doi.org/10.3233/BD-170283DOI Listing
September 2018
32 Reads

A rare benign tumor of breast masquerading on fine needle aspiration cytology: A case report.

Breast Dis 2017 ;37(2):105-107

Pleomorphic adenoma is a common tumor encountered in major salivary gland and very rarely seen in breast. This matrix producing tumor can be confused with fibroadenoma, phyllodes tumor and metaplastic carcinoma on fine needle aspiration cytology(FNAC). Pre-operative diagnosis of pleomorphic adenoma helps in preventing surgical over or under treatment of the disease. Read More

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http://dx.doi.org/10.3233/BD-170270DOI Listing
September 2018
16 Reads

Follow-up of granulomatous mastitis with monitoring versus surgery.

Breast Dis 2017 ;37(2):69-72

Background: IGM (Idiopathic Granulomatous Mastitis) is a rare, chronic, non-malignant and non-life-threatening breast disease. Clinically and radiologically, it has similar characteristics with other granulomatous diseases and breast carcinomas.

Methods: The patients whom diagnosed IGM according to pathology report were retrospectively evaluated between November 2014 and January 2016. Read More

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http://dx.doi.org/10.3233/BD-160259DOI Listing
September 2018
12 Reads

Giant juvenile fibroadenoma in a 9-year-old: A case presentation and review of the current literature.

Breast Dis 2017 ;37(2):95-98

Department of Surgery, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USA.

Juvenile fibroadenoma is the most common breast mass in adolescents accounting for 0.5-4% of all cases of fibroadenomas. Giant fibroadenomas are well-circumscribed, firm breast masses characterized by proliferation of epithelial and connective tissue. Read More

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http://dx.doi.org/10.3233/BD-160250DOI Listing
September 2018
14 Reads

The overall 5-year survival rate of breast cancer among Iranian women: A systematic review and meta-analysis of published studies.

Breast Dis 2017 ;37(2):63-68

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Breast Cancer (BC) is the most prevalent cancer and the second leading cause of cancer-related death among Iranian women. A valid estimation of the 5-year survival rate can improve the current BC treatment programs. The present study aimed to assess the 5-year survival rate through a systematic review of published studies. Read More

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http://dx.doi.org/10.3233/BD-160244DOI Listing
September 2018
14 Reads

Impaired expression of Drosha in breast cancer.

Breast Dis 2017 ;37(2):55-62

Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Impaired miRNAs processing pathway is one interesting scenario for global downregulation of the miRNAome in various types of malignancy. We previously reported that DGCR8 and Dicer genes dysregulated in patients with breast cancer.

Objective: To evaluate the expression pattern of Drosha in patients with breast cancer. Read More

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http://dx.doi.org/10.3233/BD-170274DOI Listing
September 2018
36 Reads

Gigantomastia due to retromammary lipoma: An aesthetic management.

Breast Dis 2017 ;37(1):33-37

Department of Plastic Surgery, R.G.Kar Medical College, Kolkata.

Introduction: A "giant" lipoma is defined as a tumor having dimensions greater than 10 cm. Giant lipomas are rare and giant breast lipomas are exceptionally uncommon. Only six cases have been described in world literature till date. Read More

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http://dx.doi.org/10.3233/BD-160265DOI Listing
August 2018
35 Reads

Expression analysis of long non-coding ATB and its putative target in breast cancer.

Breast Dis 2017 ;37(1):11-20

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: A long noncoding RNA (lncRNA) activated by transforming growth factor (TGF)-β (lncRNA-ATB) has been recently shown to promote the invasion-metastasis cascade in various types of cancers via upregulation of some targets including ZEB1.

Objectives: The aim of the present study was to elucidate the expression of lncRNA-ATB and ZEB in breast cancer patients.

Methods: The expression of these genes was evaluated by real-time reverse transcription polymerase chain reaction in tumor samples form 50 newly diagnosed breast cancer patients as well as their corresponding adjacent non-cancerous tissues (ANCTs). Read More

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http://dx.doi.org/10.3233/BD-160264DOI Listing
August 2018
34 Reads

The evaluation of the effect of metformin on breast fibrocystic disease.

Breast Dis 2017 ;37(2):49-53

Background: Fibrocystic changes (FCC) is the most common benign breast disease. The main pathophysiologic mechanism of FCC, excessive cell proliferation in response to monthly estrogen and progesterone changes. Regarding to antiproliferative of metformin, the aim of this study is the evaluation of the effect of metformin on FCC in women who were referred to gynecology clinics of ArakMETHODS:This study is a double blind placebo control randomized clinical trial. Read More

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http://dx.doi.org/10.3233/BD-160256DOI Listing
September 2018
10 Reads

Retinoic acid-related orphan receptor alpha (RORA) variants and risk of breast cancer.

Breast Dis 2017 ;37(1):21-25

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Breast cancer is the most common type of cancer and the second leading cause of cancer death in females. Despite numerous studies in this field, the etiology and clinical behavior of breast tumors have not been understood yet. Retinoid orphan nuclear receptor alpha (RORA) is a member of the orphan nuclear factor family involved in the regulation of lipid and steroid metabolism, immune response and circadian rhythms. Read More

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http://dx.doi.org/10.3233/BD-160248DOI Listing
August 2018
15 Reads

Huge lactating adenoma of the breast: Case report.

Breast Dis 2017 ;37(1):37-42

Assistant lecturer of surgical oncology, Oncology center Mansoura University, Mansoura, Egypt.

Introduction: Lactating adenoma is the commonest benign breast lesion seen during pregnancy and puerperium. It is commonly seen in young primigravideous women in the second or third decade during the third trimester of their pregnancy. Occasionally, lactating adenoma is large and rapidly growing and must be differentiated from malignant breast masses that could be seen during pregnancy and lactation. Read More

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http://dx.doi.org/10.3233/BD-160263DOI Listing
August 2018
19 Reads

Synchronous and metachronous breast cancer in Ukraine.

Breast Dis 2017 ;37(2):83-93

Oncology Department Bogomolets National Medical University, 03022, Kyiv, Ukraine.

Aim: This study aims to describe the current state of multiple primary malignant neoplasms (MPMNs) breast cancer patients management, evaluate the predictive impact of different factors, optimise approaches to diagnosis and treatment of these patients and improve their life quality.

Methods: The study included 2,032 patients who received special treatment at the Department of Breast Tumours and it Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 within an open randomized controlled trial. The sample included 195 patients with synchronous cancer or metachronous breast cancer. Read More

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http://dx.doi.org/10.3233/BD-170285DOI Listing
September 2018
8 Reads

Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as prognostic factors in non-metastatic breast cancer patients from a Hispanic population.

Breast Dis 2017 ;37(1):1-6

Departamento de Patología, Hospital San Juan de Dios, San José, Costa Rica.

Background: High values of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) have been associated with poor prognosis in certain tumors. Nevertheless, few data exist regarding these prognostic variables in breast cancer patients from Hispanic populations. In this study, we aimed to determine the prognostic value of these two estimates and to establish the best cutoff to categorize patients according to their risk. Read More

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http://dx.doi.org/10.3233/BD-160251DOI Listing
August 2018
9 Reads

A rare case of umbilical metastasis after delayed transverse rectus abdominis myocutaneous flap reconstruction for invasive breast cancer.

Breast Dis 2017 ;37(1):33-35

A 46-year-old female presented with an inflamed and painful umbilicus. Past medical history included breast cancer, followed by metastatic sternal cancer two years after the initial breast cancer diagnosis.The painful umbilicus was confirmed metastasis from a primary breast cancer she had treated eleven years previously. Read More

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http://dx.doi.org/10.3233/BD-160249DOI Listing
August 2018
9 Reads

Expression of TTF-1 in breast cancer independently of ER expression: A case report and pathogenic implications.

Breast Dis 2017 ;37(1):1-6

Department of Pathology, Sault Area Hospital, Sault Ste Marie, ON, Canada.

Thyroid Transcription Factor 1 (TTF-1) is often used for the immunohistochemical evaluation of lung cancers, as a significant proportion of these cancers are positive while other adenocarcinomas are usually negative. Breast cancers are known to express TTF-1 only in a small minority of cases but this may be problematic when this staining is used for its differential diagnosis from lung cancer. We present a case of ER-positive breast cancer in 30% of tumor cells that was also TTF-1 positive in some areas of the primary tumor but lost ER expression completely in the metastatic recurrence site while retaining TTF-1 positivity. Read More

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http://dx.doi.org/10.3233/BD-160240DOI Listing
August 2018
15 Reads

Breast cancer brain metastases: Molecular subtype, treatment and survival.

Breast Dis 2016 ;36(4):133-141

Division of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA.

Background: No clear guidelines exist for management of breast cancer brain metastases (BCBM).

Objective: We assessed the relationship between patient and tumor characteristics, treatment, and overall survival (OS).

Methods: We conducted a retrospective review of 196 patients who received brain radiation for BCBM between 2009-2013 at Mayo Clinic. Read More

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http://dx.doi.org/10.3233/BD-160237DOI Listing
March 2017
16 Reads

A case of multicentric low-grade neuroendocrine breast tumor with an unusual histological pattern.

Breast Dis 2016 ;36(4):161-164

Breast Unit, Salerno, Italy, A.O.U. San Giovanni di Dio e Ruggi D'Aragona, Salerno, Italy.

Neuroendocrine features are detectable in carcinomas of the breast either as scattered cells, that are recognized by their expression of neuroendocrine cell markers. Instead, pure breast carcinomas with neuroendocrine features (NEBC) are very rare and represent <1% of all breast cancer. Usually NEBC may be well or poorly differentiated and more frequent in older woman. Read More

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http://dx.doi.org/10.3233/BD-160226DOI Listing
March 2017
10 Reads