468,582 results match your criteria Breast Disease [Journal]


Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Cytometry A 2018 Dec;93(12):1213-1219

Faculty of the Heinrich-Heine, General, Visceral and Pediatric Surgery, University Hospital and Medical Faculty, University Düsseldorf, Düsseldorf, North Rhine-Westphalia, Germany.

Diagnostic leukapheresis (DLA) is based on continuous centrifugation that collects mononuclear cells from peripheral blood with a density of 1.055-1.08 g/ml. Read More

View Article
December 2018

Common genetic variants contribute to incomplete penetrance: evidence from cancer-free BRCA1 mutation carriers.

Eur J Cancer 2018 Dec 11;107:68-78. Epub 2018 Dec 11.

Department of Genetics, Cell Biology and Anatomy, College of Medicine, USA; Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau, SAR, China. Electronic address:

Purpose: The presence of pathogenic germline mutation in BRCA1 gene is considered as the most penetrant genetic predisposition for breast cancer. However, a portion of BRCA1 mutation carriers never develops breast cancer throughout their lifetime. This phenomenon is called incomplete penetrance. Read More

View Article
December 2018

Response to Dr. Ueshima et al. about erector spinae plane block use in breast cancer surgery.

J Clin Anesth 2018 Dec 10;54:145. Epub 2018 Dec 10.

Department of Anesthesiology and Reanimation, Kocaeli University, School of Medicine, Kocaeli, Turkey.

View Article
December 2018

Clinico-pathological characteristics among South African women with breast cancer receiving anti-retroviral therapy for HIV.

Breast 2018 Dec 7;43:123-129. Epub 2018 Dec 7.

Non-Communicable Diseases Research Division, Wits Health Consortium (PTY) Ltd, 31 Princess of Wales Building, Johannesburg, 2193, South Africa; Department of Medicine, University of Witwatersrand Faculty of Health Sciences, 7 York Road Johannesburg, South Africa.

Purpose: Breast cancer is the most common cancer in women and a leading cause of cancer-related mortality worldwide. South Africa has the largest global burden of HIV infection and the largest anti-retroviral treatment (ART) program. This study aimed to analyse the association of HIV and ART use with breast cancer clinico-pathological characteristics. Read More

View Article
December 2018

Sexuality, a topic that surgeons should discuss with women before risk-reducing mastectomy and breast reconstruction.

Breast 2018 Dec 6;43:120-122. Epub 2018 Dec 6.

Department of Plastic, Reconstructive and Hand Surgery, VUmc, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, the Netherlands.

While sexual health is an important aspect of quality of life, sexual issues usually go unaddressed during patient-provider communication. Breast cancer treatments and specifically breast surgery impact women's sexual well-being. However, women do not receive adequate information on this subject. Read More

View Article
December 2018

Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland.

Neoplasia 2018 Dec 11;21(1):132-145. Epub 2018 Dec 11.

Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH 43210; The James Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210. Electronic address:

The organization of the extracellular matrix has a profound impact on cancer development and progression. The matrix becomes aligned throughout tumor progression, providing "highways" for tumor cell invasion. Aligned matrix is associated with breast density and is a negative prognostic factor in several cancers; however, the underlying mechanisms regulating this reorganization remain poorly understood. Read More

View Article
December 2018

Black and Minority Ethnic women's decision-making for risk reduction strategies after BRCA testing: Use of context and knowledge.

Eur J Med Genet 2018 Dec 11. Epub 2018 Dec 11.

King's College London, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, London, United Kingdom; Faculty of Health and Wellbeing, Sheffield Hallam University, Sheffield, United Kingdom.

Within the field of breast cancer care, women concerned about their family history are offered genetic testing and subsequent treatment options based on several factors which include but are not limited to personal and family cancer disease histories and clinical guidelines. Discussions around decision-making in genetics in Black and Minority Ethnic (BME) groups are rarely documented in literature, and information regarding interactions with genetics services is usually discussed and linked to lack of scientific knowledge. As such, counselling sessions based only on scientific and medical information miss out the many reasons participants consider in making health decisions, information which can be used to encourage BME women to engage in cancer genetics services. Read More

View Article
December 2018

Dosimetric effects of the kV based image-guided radiation therapy of prone breast external beam radiation: Towards the optimized imaging frequency.

J Appl Clin Med Phys 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.

Purpose: For prone breast treatment, daily image-guided radiation therapy (IGRT) allows couch shifting to correct breast position relative to the treatment field. This work investigates the dosimetric effect of reducing kV imaging frequencies and the feasibility of optimizing the frequency using patient anatomy or their first 3-day shifts.

Method: Thirty-seven prone breast patients who had been treated with skin marker alignment followed by daily kV were retrospectively analyzed. Read More

View Article
December 2018
1 Read

Serum inhibin B concentration as a predictor of age at first menstruation in girls with idiopathic central precocious puberty.

PLoS One 2018 14;13(12):e0205810. Epub 2018 Dec 14.

Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, Paris, France.

Objective: To compare the serum inhibin B, anti-Müllerian hormone (AMH) and leptin concentrations in girls with idiopathic central precocious puberty (CPP) to their concomitant characteristics and evaluate the capacity of each of these hormones to predict the age at first menstruation in those who were untreated and who completed their puberty.

Methods: This single-center study included 94 girls selected from a cohort of 493 girls seen between 1981 and 2012 and diagnosed with idiopathic CPP for whom a remaining serum sample collected at the initial evaluation was available. Of these 25 were untreated and completed their puberty. Read More

View Article
December 2018

Pathologic Prognostic Factors in Endometrial Carcinoma (Other Than Tumor Type and Grade).

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S93-S113

Department of Cellular Pathology, Barts Health NHS Trust, London (N.S.) Department of Cellular Pathology, Birmingham Women's NHS Trust, Birmingham (L.H.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK Division of Anatomic Pathology, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania (R.Z.) Department of Pathology, Mexico City Hospital of Oncology, Mexico City, Mexico (I.A.-C.) Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, Alberta, Canada (M.A.D.) Department of Pathology, Wayne State University, Detroit, Michigan (R.A.-F.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (E.E., A.M.) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (J.L.H.) Department of Pathology, Brigham and Women's Hospital, Harvard Medical School (M.N.) Department of Pathology, Massachusetts General Hospital, Harvard Medical School (E.O.), Boston, Massachusetts Division of Gynecologic, Breast & Perinatal Pathology, University Hospital Leipzig, Leipzig (L.-C.H.) Institute of Pathology, University Hospital of Tübingen, Tübingen (A.S.), Germany Department of Anatomical Pathology, University of Maryland, College Park, Maryland (O.I.) Pathological Oncology Group and Pathology Department, University Hospital of Arnau de Vilanova, Lleida (X.M.-G.) Department of Pathology, Hospital Clinic of Barcelona, ISGlobal, Barcelona Center for International Health Research, University of Barcelona, Barcelona (J.O.), Spain Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan (Y.M.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Department of Pathology, Women and Infants Hospital/Warren Alpert Medical School of Brown University, Providence, Rhode Island (M.R.Q.) Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (C.M.Q.) Department of Pathology, University of California, San Francisco, San Francisco, California (C.Z.).

Although endometrial carcinoma (EC) is generally considered to have a good prognosis, over 20% of women with EC die of their disease, with a projected increase in both incidence and mortality over the next few decades. The aim of accurate prognostication is to ensure that patients receive optimal treatment and are neither overtreated nor undertreated, thereby improving patient outcomes overall. Patients with EC can be categorized into prognostic risk groups based on clinicopathologic findings. Read More

View Article
January 2019

Endometrial Carcinoma, Grossing and Processing Issues: Recommendations of the International Society of Gynecologic Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S9-S24

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M., E.D.E.) Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School (J.L.H.) Department of Pathology, Massachusetts General Hospital and Harvard Medical School (E.O.), Boston, Massachusetts Department of Pathology, Wayne State University, Detroit, Michigan (R.A.F.) Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas (C.M.Q.) Department of Cellular Pathology, Barts Health NHS Trust, London (N.S.) Department of Cellular Pathology, Birmingham Women's NHS Trust, Birmingham (L.H.), UK Division of Gynecologic, Breast and Perinatal Pathology, University Hospital, Leipzig (L.C.H.) Institute of Pathology, University Hospital of Tübingen, Tübingen (A.S.), Germany Department of Pathology, Hospital de Oncología Siglo XXI, Mexico City, Mexico City, Mexico (I.A.C.) Department of Pathology, Hospital Universitari de Bellvitge and Hospital Universitari de Arnau de Vilanova, Idibell, Irblleida, and Universitat de Lleida, Ciberonc (X.M.G.) Department of Pathology, Hospital Clinic of Barcelona, Universitat de Barcelona, Barcelona (J.O.), Spain Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada (M.D.) Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (V.P.) Department of Diagnostic Pathology, Kumamoto University Hospital, Kumamoto, Japan (Y.M.) Department of Pathology, Women and Infants Hospital and The Warren Alpert Medical School of Brown University, Providence, Rhode Island (M.R.Q.) Division of Anatomic Pathology, Hershey Medical Center, Pennsylvania State University, Hershey, Pennsylvania (R.Z.) Department of Pathology, University of California, San Francisco, San Francisco, California (C.Z.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.).

Endometrial cancer is the most common gynecologic neoplasm in developed countries; however, updated universal guidelines are currently not available to handle specimens obtained during the surgical treatment of patients affected by this disease. This article presents recommendations on how to gross and submit sections for microscopic examination of hysterectomy specimens and other tissues removed during the surgical management of endometrial cancer such as salpingo-oophorectomy, omentectomy, and lymph node dissection-including sentinel lymph nodes. In addition, the intraoperative assessment of some of these specimens is addressed. Read More

View Article
January 2019

Hypogonadotropic hypogonadism and pituitary hypoplasia as recurrent features in Ulnar-Mammary syndrome.

Endocr Connect 2018 Dec;7(12):1432-1441

IRCCS Istituto Auxologico Italiano, Service of Medical Genetics, Milan, Italy.

Ulnar-mammary syndrome (UMS) is characterized by ulnar defects, and nipple or apocrine gland hypoplasia, caused by TBX3 haploinsufficiency. Signs of hypogonadism were repeatedly reported, but the mechanisms remain elusive. We aim to assess the origin of hypogonadism in two families with UMS. Read More

View Article
December 2018

Communicating Risks of Adjuvant Chemotherapy for Breast Cancer: Getting Beyond the Laundry List.

J Oncol Pract 2018 Dec 14:JOP1800162. Epub 2018 Dec 14.

UCLA Jonsson Comprehensive Cancer Center; UCLA Anderson School of Management; UCLA Schools of Medicine and Public Health, Los Angeles; UC Davis Center for Healthcare Policy and Research, Davis, CA; and University of Texas Health Sciences Center, San Antonio, TX.

Purpose:: According to the Institute of Medicine, high-quality cancer care should include effective communication between clinicians and patients about the risks and benefits, expected response, and impact on quality of life of a recommended therapy. In the delivery of oncology care, the barriers to and facilitators of communication about potential long-term and late effects, post-treatment expectations, and transition to survivorship care have not been fully defined.

Patients And Methods:: We collected qualitative data through semistructured interviews with medical oncologists and focus groups with breast cancer survivors and applied the Theoretical Domains Framework to systematically analyze and identify the factors that may influence oncologists' communication with patients with breast cancer about the long-term and late effects of adjuvant therapy. Read More

View Article
December 2018

Bone-targeted agent treatment patterns and the impact of bone metastases on patients with advanced breast cancer in the United States.

Curr Med Res Opin 2018 Dec 14:1-16. Epub 2018 Dec 14.

e Global Health Economics, Amgen Inc. , Thousand Oaks , CA , USA.

Objective: Bone metastases are common among patients with advanced breast cancer, putting patients at increased risk of skeletal-related events (SREs). This study described impact of bone metastases, utilization of bone-targeted agents (BTAs) and physicians' decision processes for BTA use in advanced breast cancer.

Methods: Data were collected using the Adelphi Breast Cancer Disease-Specific Programme in the United States. Read More

View Article
December 2018
1 Read

Real-time Visualization of Breast Carcinoma in Pathology Specimens From Patients Receiving Fluorescent Tumor-Marking Agent Tozuleristide.

Arch Pathol Lab Med 2018 Dec 14. Epub 2018 Dec 14.

From the Departments of Pathology (Dr Dintzis) and Surgery (Ms Hales and Drs Calhoun, Javid, and Byrd), University of Washington Medical Center, Seattle; Breast Surgery Clinic (Dr Harrington), Department of Pathology (Dr Tan), and Clinical Trials (Mses Fortney and Porenta), Overlake Hospital Medical Center, Bellevue, Washington; Development (Dr Miller), Clinical Operations (Mses Ishak and Gombotz), Research (Ms Hansen and Dr Parrish-Novak), and Device Development (Dr Kittle and Mr Perry), Blaze Bioscience, Inc., Seattle, Washington; and the Department of Surgery, University of Washington, Seattle (Dr Anderson).

Context.—: Resection of breast carcinoma with adequate margins reduces the risk of local recurrence and reoperation. Tozuleristide (BLZ-100) is an investigational peptide-fluorophore agent that may aid in intraoperative tumor detection and margin assessment. Read More

View Article
December 2018

Use of colony-stimulating factor primary prophylaxis and incidence of febrile neutropenia from 2010-2016: a longitudinal assessment.

Curr Med Res Opin 2018 Dec 14:1-15. Epub 2018 Dec 14.

b Amgen Inc. , Thousand Oaks , CA.

Background: Guidelines recommend primary prophylactic use of colony-stimulating factor (PP-CSF) when risk of febrile neutropenia (FN)-based on chemotherapy and patient risk factors-is high. Whether and how PP-CSF use may have changed over time (e.g. Read More

View Article
December 2018

Sugar Concentration and Arrangement on the Surface of Glycopolymer Micelles Affect the Interaction with Cancer Cells.

Biomacromolecules 2018 Dec 14. Epub 2018 Dec 14.

Centre for Advanced Macromolecular Design (CAMD), School of Chemistry , University of New South Wales , Sydney NSW 2052 , Australia.

Glycopolymer-coated nanoparticles have attracted significant interest over the past few years, because of their selective interaction with carbohydrate receptors found on the surface of cells. While the type of carbohydrate determines the strength of the ligand-receptor interaction, the presentation of the sugar can be highly influential as the carbohydrate needs to be accessible in order to display good binding. To shine more light on the relationship between nanoparticle structure and cell uptake, we have designed several micelles based on fructose containing block copolymers, which are selective to GLUT5 receptors found on breast cancer cell lines. Read More

View Article
December 2018

[BABA of da Vinci robot thyroid surgery in the standard treatment of thyroid cancer surgery].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1071-1074

Departmeng of Thyroid and Breast Surgery, Jinan Military General Hospital, Jinan, 250031, China.

Thyroid cancer is the most common malignant tumor in endocrine surgery. Surgery is the first choice for most patients with thyroid cancer. Da Vinci robot system as the auxiliary system is the most advanced endoscopic surgery, largely to fill the cavity mirror device cannot bend, complex operation and so on insufficiency, has now become an important way of surgical treatment of thyroid cancer, and its curative effect, high safety, but because of the economic cost is higher, is currently not widespread popularity. Read More

View Article

[Application of da Vinci robot's bilateral axillo-breast approach in thyroid surgery of obese patients].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Jul;32(14):1061-1065

Departmeng of Thyroid and Breast Surgery, Jinan Military General Hospital, Jinan, 250031, China.

To discuss the effect of obesity on the operation of thyroid gland surgery and surgical results.The clinical data of 446 patients who underwent robot thyroid surgery through bilateral axillo-breast approach (BABA) from the General Hospital of Jinan Military region from February 2014 to November 2017 were analyzed retrospectively, and the patients were divided into BMI<25 kg/m²; group, BMI 25-30 kg/m²; group and BMI>30 kg/m²; group according to body mass index (BMI). The operative complications were compared between the three groups of benign and malignant patients, such as operation time, postoperative lead flow, postoperative hospitalization time, tumor size (malignant), lymph node metastasis (malignant), cosmetic satisfaction score, laryngeal nerve injury and parathyroid function decrease. Read More

View Article

[Validation of the Cognitive Emotional Regulation Questionnaire in Mexican patients with breast cancer].

Salud Publica Mex 2018 Sep-Oct;60(5):488-489

Joven y Fuerte: Programa para la Atención e Investigación de Mujeres Jóvenes con Cáncer de Mama, Instituto Nacional de Cancerología. Ciudad de México.

View Article
December 2018

BDNF Val66Met is Associated with Pre-existing but not with Paclitaxel-induced Peripheral Neuropathy in an Israeli Cohort of Breast Cancer Patients.

Isr Med Assoc J 2018 Dec;20(12):746-748

Department of Hematology, Galilee Medical Center, Nahariya, Israel, affiliated with Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel.

Background: Brain-derived neurotrophic factor (BDNF) is a neuronal growth factor that is important for the development, maintenance, and repair of the peripheral nervous system. The BDNF gene commonly carries a single nucleotide polymorphism (Val66Met-SNP), which affects the cellular distribution and activity-dependent secretion of BDNF in neuronal cells.

Objectives: To check the association between BDNF Val66Met-SNP as a predisposition that enhances the development of chemotherapy-induced peripheral neuropathy in an Israeli cohort of patients with breast cancer who were treated with paclitaxel. Read More

View Article
December 2018

Mammary carcinoma with osteoclast-like giant cell: fine needle aspiration and cytological diagnosis of a rare and misleading subtype of invasive ductal carcinoma.

Cytopathology 2018 Dec 14. Epub 2018 Dec 14.

Department of Pathology and Cytology, Brest University Hospital, Brest, France.

Mammary carcinoma with osteoclast-like giant cell is a very rare subtype of invasive ductal carcinoma not otherwise specified of the WHO classification of Breast tumors . This tumor has a similar prognosis to other breast carcinomas of identical grade and stage. Nevertheless, its clinical and radiological presentation is falsely reassuring and can lead to a damaging diagnosis delay. Read More

View Article
December 2018

Helping Her Heal: Randomized Clinical Trial to Enhance Dyadic Outcomes in Couples.

Psychooncology 2018 Dec 13. Epub 2018 Dec 13.

University of Washington, School of Nursing, Seattle, WA.

Objective: To test the short-term efficacy of a brief, fully manualized marital communication and interpersonal support intervention for couples facing recently diagnosed breast cancer.

Methods: A total of 322 women diagnosed within 6 months with Stage 0-III breast cancer and their 322 spouse caregivers were enrolled. Spouses in the experimental group received five, 30 to 60-minute intervention sessions at 2-week intervals by Masters prepared patient educators; controls received the booklet, "What's Happening to the Woman I Love?" Outcomes were assessed at 3, 6 and 9 months using Linear Mixed Models within an intent to treat analysis. Read More

View Article
December 2018

MicroRNA-1204 promotes cell proliferation by regulating PITX1 in non-small cell lung cancer.

Cell Biol Int 2018 Dec 14. Epub 2018 Dec 14.

Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

MicroRNA-1204 (miR-1204), a member of the PVT1 region, may improve B cell differentiation and metastasis in breast cancer. However, the role of miR-1204 in NSCLC (non-small cell lung cancer) and its mechanism remain unclear. The GEO public database was first employed to find differentially expressed genes. Read More

View Article
December 2018

Multiple primary lung cancer versus intrapulmonary metastatic cancer: A case of multiple pulmonary nodules.

Thorac Cancer 2018 Dec 13. Epub 2018 Dec 13.

Department of Thoracic Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

A preoperative chest computed tomography examination of the right breast in a 52-year-old woman with breast cancer revealed multiple nodules in both lungs. The nodule in the apical segment of the upper lobe of the right lung was larger, at a diameter of approximately 2.1 cm. Read More

View Article
December 2018

Comparative effectiveness of radiotherapy for early-stage hormone receptor-positive breast cancer in elderly women using real-world data.

Cancer Med 2018 Dec 12. Epub 2018 Dec 12.

Pharmaceutical Outcomes & Policy (POP), College of Pharmacy, University of Florida, Gainesville, Florida.

Background: Radiotherapy is the recommended treatment after breast-conserving surgery (BCS) for early-stage breast cancer (BC). However, there is no clear evidence whether radiotherapy after BCS improves the survival of elderly women diagnosed with early-stage hormone receptor-positive (HR+) BC. The aim of this study was to investigate the survival benefit associated with radiotherapy plus hormonal therapy vs hormonal therapy alone after BCS for early-stage HR+ BC patients. Read More

View Article
December 2018

External validation of the PREDICT tool in Spanish women with breast cancer participating in population-based screening programmes.

J Eval Clin Pract 2018 Dec 12. Epub 2018 Dec 12.

Department of Epidemiology and Evaluation, IMIM-Hospital del Mar, Research Network on Health Services in Chronic Diseases (REDISSEC), Barcelona, Spain.

Rationale, Aims, And Objectives: To externally validate the PREDICT tool in a cohort of women participating in a population-based breast cancer screening programme who were diagnosed with breast cancer between 2000 and 2008 in Spain.

Methods: A total of 535 women were included in the validation study. We calculated predicted 5-year survival using the beta values from the development of the PREDICT model and predicted and observed events for a given risk groups. Read More

View Article
December 2018

Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells.

Phytother Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmacology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

Changes in cellular biomechanical properties affect cell migration and invasion. The natural compound Cucurbitacin B (CuB) has potent anticancer activity; however, the mechanism underlying its inhibitory effect on breast cancer metastasis needs further study. Here, we showed that low-dose CuB inhibited adhesion and altered the viscoelasticity of breast cancer cells, thereby, reducing cell deformability. Read More

View Article
December 2018

Self-objectification in the context of breastfeeding: A concept analysis.

Public Health Nurs 2018 Dec 12. Epub 2018 Dec 12.

School of Nursing and Health Studies, University of Miami, Coral Gables, Florida.

To increase the overall rate of breastfeeding initiation and duration, factors involved in a mother's decision to breastfeed must be identified. Self-objectification in the context of breastfeeding was a concept selected for exploring factors associated with negative views of breastfeeding. A concept analysis following the eight-step Walker & Avant method provides clarity and context to the concept of self-objectification in the context of breastfeeding. Read More

View Article
December 2018

Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases.

Breast J 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, University of Florida, Gainesville, Florida.

This article presents current best knowledge to assess the projected outcomes benefit of adding multi-modality surveillance imaging to standard follow-up care for breast cancer patients at high risk (>30%) for developing future metastases. This analysis is motivated by recent preliminary clinical studies that have suggested that augmenting systemic treatment of early-stage metastases with targeted surgery and/or radiosurgery achieves significant overall survival and disease-free survival benefit. Our primary aims are to: (a) describe the clinical motivation and scan parameters needed to identify the early onset of metastatic progression in breast cancer patients for effective surgical or radiosurgical treatment; (b) estimate the anticipated survival benefit for high-risk patients under this recommended protocol; and (c) estimate the radiation risks associated with the repeated body imaging of this protocol. Read More

View Article
December 2018

High- and Ultra-High definition of IR spectral histopathology gives an insight into chemical environment of lung metastases in breast cancer.

J Biophotonics 2018 Dec 12:e201800345. Epub 2018 Dec 12.

Faculty of Chemistry, Jagiellonian University, Poland.

Using high- (HD) and ultra-high-definition (UHD) of Fourier Transform Infrared (FTIR) spectroscopic imaging, we characterised spectrally pulmonary metastases in a murine model of breast cancer comparing them with histopathological results (H&E staining). This comparison showed excellent agreement between the methods in case of localisation of metastases with size below 1 mm and revealed that label-free HD and UHD IR spectral histopathology distinguish the type of neoplastic cells. We primary focused on differentiation between metastatic foci in the pleural cavity from cancer cells present in lung parenchyma and inflamed cells present in extracellular matrix of lungs due to growing of advanced metastases. Read More

View Article
December 2018

Reliability, validity, and sensitivity of the Chinese Short-Form 36 Health Survey version 2 (SF-36v2) in women with breast cancer.

J Eval Clin Pract 2018 Dec 12. Epub 2018 Dec 12.

School of Nursing, Xi'an Jiaotong University Health Science Centre, Xi'an, China.

Rationale, Aims, And Objectives: The psychometrics of the Short-Form 36 Health Survey version 2 (SF-36v2) in female breast cancer patients remains unknown. This study aimed to test the reliability, validity, and sensitivity of the Chinese SF-36v2 in women with breast cancer.

Methods: The sample included 326 eligible participants. Read More

View Article
December 2018

Breast cancer-linked lncRNA u-Eleanor is upregulated in breast of healthy women with lack or short duration of breastfeeding.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Recently, it has been revealed that estrogen-related reproductive factors are linked with some early gene expression lesions associated with malignancy in clinically healthy breasts. Accordingly, the aim of the current study was to evaluate the association of expression levels of estrogen-related long noncoding RNAs (lncRNAs) upstream Eleanor (u-Eleanor) and HOX antisense intergenic RNA (HOTAIR) with the different patterns of reproductive factors in breast tissue of healthy women. The subjects of this study were 98 cancer-free women who had undergone cosmetic mammoplasty. Read More

View Article
December 2018

Natural forms of vitamin E and metabolites-regulation of cancer cell death and underlying mechanisms.

Authors:
Qing Jiang

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Nutrition Science, Purdue University, West Lafayette, Indiana, 47907, USA.

The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown that specific forms of vitamin E such as γ-tocopherol (γT), δ-tocopherol (δT), γ-tocotrienol (γTE) and δ-tocotrienol (δTE) can inhibit the growth and induce death of many types of cancer cells, and are capable of suppressing cancer development in preclinical cancer models. For these activities, these vitamin E forms are much stronger than αT. Read More

View Article
December 2018

PTP1B markedly promotes breast cancer progression and is regulated by miR-193a-3p.

FEBS J 2018 Dec 7. Epub 2018 Dec 7.

State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing University, 163 Xianlin Road, Nanjing, Jiangsu, 210023, China.

The protein tyrosine phosphatase PTP1B, which is encoded by PTPN1, is a ubiquitously expressed non-receptor protein tyrosine phosphatase. PTP1B has long been known to negatively regulate insulin and leptin receptor signalling. Recently, it was reported to be aberrantly expressed in cancer cells and to function as an important oncogene. Read More

View Article
December 2018

Breast Asymmetry in Women Requesting Plastic Surgery of the Breast.

Authors:
Norma I Cruz

P R Health Sci J 2018 Dec;37(4):230-238

Department of Surgery, Div. of Plastic Surgery, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, PR.

Objective: Breast asymmetries have a high prevalence among women requesting breast augmentation. However, the prevalence of breast asymmetries in women undergoing other types of breast surgeries is not known.

Methods: The breast measurements of consecutively women evaluated for plastic surgery of the breast, but without prior breast surgery, were prospectively recorded in a plastic surgery database. Read More

View Article
December 2018

Financial Toxicity Among Women With Metastatic Breast Cancer.

Oncol Nurs Forum 2019 Jan;46(1):83-91

University of Pittsburgh.

Objectives: To determine the incidence of financial toxicity among women with metastatic breast cancer, as well as the relationships among financial toxicity, quality of life, and overall cancer-related distress in members of this patient population.

Sample & Setting: 145 women with metastatic breast cancer receiving care at an urban outpatient breast cancer clinic.

Methods & Variables: A cross-sectional analysis of women with metastatic breast cancer was performed. Read More

View Article
January 2019

Comparison of Health-Related Quality of Life Between Adjuvant Breast Cancer Treatment Groups.

Oncol Nurs Forum 2019 Jan;46(1):59-70

Bastyr University.

Objectives: To compare the health-related quality of life (HRQOL) of women who did (receivers, n = 372) and did not (intentional nonreceivers, n = 46) receive all recommended adjuvant treatments for breast cancer.

Sample & Setting: Women were recruited through integrative oncology clinics and the Cancer Surveillance System registry in western Washington.

Methods & Variables: A cross-sectional and correlational study using secondary data was conducted. Read More

View Article
January 2019

Evidence of promoting prevention and the early detection of breast cancer among women, a hospital-based education and screening interventions in low- and middle-income countries: a systematic review protocol.

Syst Rev 2018 Dec 14;7(1):234. Epub 2018 Dec 14.

Discipline of Nursing, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, 4001, South Africa.

Background: Given the increasing burden of breast cancer in the low- and middle-income countries, cost-effective approaches are needed to improve the early detection of breast cancer in these continents. Global policies and guidelines are now placing much emphasis on promoting early detection of breast cancer through integrated education and screening interventions. The proposed systematic review aims to map evidence on hospital-based breast cancer education, breast self-examination, and clinical breast examination services for women in low- and middle-income countries. Read More

View Article
December 2018

Influence of endocrine therapy on the ratio of androgen receptor (AR) to estrogen receptor (ER) positive circulating epithelial tumor cells (CETCs) in breast cancer.

J Transl Med 2018 Dec 14;16(1):356. Epub 2018 Dec 14.

Transfusion Center Bayreuth, Bayreuth, Germany.

Background: The androgen receptor (AR) is expressed in the majority of breast cancers and across the main breast cancer subtypes. Despite the high frequency of AR expression in breast cancer its appraisal remains controversial because its role is complex, dependent on the hormonal milieu. The aim of the current study was to investigate the frequency of AR and ER positive CETCs in breast cancer patients. Read More

View Article
December 2018

Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors.

J Exp Clin Cancer Res 2018 Dec 14;37(1):314. Epub 2018 Dec 14.

The Irma H. Russo, MD Breast Cancer Research Laboratory, Fox Chase Cancer Center-Temple University Health System, Philadelphia, PA, 19111, USA.

Background: Triple negative breast cancer (TNBC) is an aggressive neoplasia with no effective therapy. Our laboratory has developed a unique TNBC cell model presenting epithelial mesenchymal transition (EMT) a process known to be important for tumor progression and metastasis. There is increasing evidence showing that epigenetic mechanisms are involved in the activation of EMT. Read More

View Article
December 2018

Complete pathological response following neoadjuvant FOLFOX chemotherapy in BRCA2-mutant locally advanced rectal cancer: a case report.

BMC Cancer 2018 Dec 14;18(1):1253. Epub 2018 Dec 14.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Patients with locally advanced rectal cancer (LARC) achieving a pathological complete response (pCR) to neoadjuvant treatment usually have a good prognosis, but only accounted for less than 20%.

Case Presentation: We report a case of a 25-year-old male with LARC treated with neoadjuvant FOLFOX chemotherapy, and experienced a pCR. The next-generation sequencing analysis revealed the presence of breast cancer gene 2 (BRCA2) somatic mutation and an increased somatic mutational load without microsatellite instability (MSI). Read More

View Article
December 2018

Invited Commentary on "An Analysis of Nipple Enhancement at Breast MRI with Radiologic-Pathologic Correlation".

Radiographics 2018 Dec 14:180209. Epub 2018 Dec 14.

Department of Radiology, Emory University Atlanta, Georgia.

View Article
December 2018

An Analysis of Nipple Enhancement at Breast MRI with Radiologic-Pathologic Correlation.

Radiographics 2018 Dec 14:180039. Epub 2018 Dec 14.

From the Departments of Radiology (Y.G., S.L.H.) and Pathology (O.H.), New York University Langone Medical Center, 160 E 34th St, New York, NY 10016; and Department of Pathology, Massachusetts General Hospital, Boston, Mass (E.F.B.).

Breast MRI is the most sensitive imaging modality for assessment of the nipple-areola complex (NAC), which is important both in cancer staging and in high-risk screening. However, the normal appearance of the nipple at MRI is not well defined because of a paucity of scientific literature on this topic. Hence, there is a lack of descriptive terminology and diagnostic criteria, which may account for the wide variability in interpretation among radiologists when assessing the NAC on MR images. Read More

View Article
December 2018

A case of chemoradiotherapy-associated cardiotoxicity that developed into acute heart failure with progressive subendocardial fibrosis.

J Cardiol Cases 2014 Sep 10;10(3):115-120. Epub 2014 Jul 10.

Department of Breast Surgery, Niigata Cancer Center Hospital, Niigata, Japan.

We describe the case of a 61-year-old Japanese woman who developed acute heart failure 5 years after chemoradiotherapy for breast cancer. The patient received less than the cardiotoxic dose of docetaxel, epirubicin, cyclophosphamide, and fluorouracil and experienced no cardiovascular complications in the 5 years between the onset of chemoradiotherapy and the onset of acute heart failure. Cardiac catheterization was performed and elevation of end diastolic pressure of both ventricles was observed. Read More

View Article
September 2014

Sources of Mercury Exposure to Children in Low- and Middle-Income Countries.

J Health Pollut 2015 Jun 2;5(8):33-51. Epub 2015 Jul 2.

Civil and Environmental Engineering, Department, U.C.L.A., Los Angeles, CA, U.S.A.

Background: Many children in low- and middle-income countries face enhanced risks of exposure to contaminants via the environment, parental occupation, and other routes. While mercury (Hg) is a global pollutant whose transport properties allow it to have an impact even in pristine areas, the presence of significant Hg sources in the developing world can cause localized effects that are more severe than those observed in other areas.

Objectives: This paper provides a narrative review of sources of Hg exposure to people in the developing world with a particular focus on children, and presents an overview of key aspects to this important issue. Read More

View Article

Successful treatment of prolonged cardiopulmonary arrest of Kounis syndrome during coronary angioplasty.

J Cardiol Cases 2016 Feb 8;13(2):47-51. Epub 2015 Dec 8.

Department of Cardiology, Akashi Medical Center, Akashi, Japan.

We experienced a case of Kounis syndrome with cardiopulmonary arrest and severe coronary spasm. A 70-year-old man with cardiac pacemaker and chronic dialysis was treated for angina pectoris of the right coronary artery. After diagnostic coronary angiography of the right coronary artery, optical coherence tomography was performed with contrast medium and low-molecular-weight dextran. Read More

View Article
February 2016

A case of radiation-induced subclavian artery stenosis treated with percutaneous transluminal angioplasty.

J Cardiol Cases 2015 Aug 4;12(2):61-64. Epub 2015 Jun 4.

Department of Cardiovascular Medicine, Tokyo Teishin Hospital, 2-14-23 Fujimi, Chiyodaku, Tokyo, Japan.

We report on a female patient who underwent a standard radical mastectomy and radiation therapy for right breast cancer at the age of 50 years without recurrence. At the age of 76 years, she started to experience fatigue in the right upper limb. The symptom gradually worsened and she was admitted to our hospital for further investigation. Read More

View Article

A Multiattribute Gaussian Graphical Model for Inferring Multiscale Regulatory Networks: An Application in Breast Cancer.

Methods Mol Biol 2019 ;1883:143-160

UMR MIA-Paris, AgroParisTech, INRA, Université Paris-Saclay, Paris, France.

This chapter addresses the problem of reconstructing regulatory networks in molecular biology by integrating multiple sources of data. We consider data sets measured from diverse technologies all related to the same set of variables and individuals. This situation is becoming more and more common in molecular biology, for instance, when both proteomic and transcriptomic data related to the same set of "genes" are available on a given cohort of patients. Read More

View Article
January 2019

Intensity-modulated radiotherapy and hypofractionated volumetric modulated arc therapy for elderly patients with breast cancer: comparison of acute and late toxicities.

Radiol Med 2018 Dec 13. Epub 2018 Dec 13.

Radiation Oncology, Cancer Care Center, Ospedale Sacro Cuore don Calabria, via Don Sempreboni 5, 37034, Negrar, Verona, Italy.

Purpose: To evaluate the differences between conventional fractionated intensity-modulated radiotherapy (IMRT) and hypofractionated (HypoRT) volumetric modulated arc therapy (VMAT) in elderly women affected by early-stage breast cancer (BC) in terms of RT-related acute/late side effect.

Materials And Methods: Between October 2011 and July 2015, 80 consecutive elderly BC patients were treated with IMRT for 5 weeks (40 patients) or HypoRT-VMAT for 3 weeks (40 patients). Inclusion criteria were: age ≥ 70 years, early BC (pT1-2 pN0-1), no prior neoadjuvant chemotherapy and non-metastatic disease. Read More

View Article
December 2018