34,992 results match your criteria Breast Cancer Ultrasonography


Digital Breast Tomosynthesis for Intraoperative Margin Assessment during Breast-Conserving Surgery.

Ann Surg Oncol 2019 Mar 14. Epub 2019 Mar 14.

Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Intraoperative margin assessment for breast cancer patients undergoing segmental mastectomy (SM) enables identification of positive margins, with immediate excision of additional tissue to obtain negative margins.

Objective: The aim of this study was to determine the ability of digital breast tomosynthesis (DBT) to detect positive margins compared with an institution's standard extensive processing (SEP).

Methods: SM specimens underwent intraoperative SEP with two-dimensional (2D) imaging of the intact and sliced specimen, with review by a breast radiologist and gross assessment by a breast pathologist. Read More

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http://dx.doi.org/10.1245/s10434-019-07226-wDOI Listing

Sonographic Features of Flat Epithelial Atypia Manifesting as a Non-Mass-Like Lesion: A Case Report.

Am J Case Rep 2019 Mar 15;20:340-344. Epub 2019 Mar 15.

Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND The incidence of flat epithelial atypia of the breast has been increasing owing to the increasing use of ultrasonography (US) and US-guided core needle biopsy. However, reports describing the sonographic features of flat epithelial atypia are fewer than those on its mammographic features. CASE REPORT A 47-year-old female had a regular 6 month-interval follow-up US for multiple bilateral breast masses detected on US. Read More

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http://dx.doi.org/10.12659/AJCR.914178DOI Listing

Novel tumor-infiltrating lymphocytes ultrasonography score based on ultrasonic tissue findings predicts tumor-infiltrating lymphocytes in breast cancer.

Breast Cancer 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3-Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-0037, Japan.

Background: The presence of tumor-infiltrating lymphocytes (TILs) is a prognostic factor for breast cancer. However, because of tumor tissue heterogeneity, an accurate and simple evaluation method is needed. We determined if preoperative characteristic ultrasonography (US) image findings are predictive of lymphocyte-predominant breast cancer (LPBC). Read More

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http://dx.doi.org/10.1007/s12282-019-00958-3DOI Listing

Incidental Detection of Carcinoma In-situ in Fibroadenoma of the Breast in a Young Woman: A Rare Finding.

Cureus 2018 Dec 31;10(12):e3797. Epub 2018 Dec 31.

Department of Pathology, Mahatma Gandhi Medical College & Hospital, Jaipur, IND.

Fibroadenoma, being a very common benign tumor of the breast in young females, does not pose any threat and, thus, can be treated with lumpectomy. Breast cancer arising within a fibroadenoma is a rare phenomenon, but detecting these neoplasms is of utmost importance for complete treatment and follow-up. These lesions are an incidental finding in a lumpectomy specimen done for fibroadenoma breast. Read More

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http://dx.doi.org/10.7759/cureus.3797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402743PMC
December 2018

Association between digital breast tomosynthesis and molecular subtypes of breast cancer.

Oncol Lett 2019 Mar 10;17(3):2669-2676. Epub 2019 Jan 10.

Department of Imaging, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362001, P.R. China.

In recent years, with increasing prevalence, particularly in young patients, breast cancer is considered to be one of the most common malignancies. The aim of the present study was to evaluate the clinical value of digital breast tomosynthesis (DBT) in diagnosing molecular subtypes of breast cancer. The present study retrospectively analyzed 134 cases of breast cancer with data regarding surgery, complete pathology and immunohistochemistry, which were collected at The Second Clinical College of Fujian Medical University (Quanzhou, China) between May 2013 and October 2014. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.9918
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http://dx.doi.org/10.3892/ol.2019.9918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366033PMC
March 2019
1 Read

CT features of parathyroid carcinomas: comparison with benign parathyroid lesions.

Jpn J Radiol 2019 Mar 12. Epub 2019 Mar 12.

Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima City, 890-8544, Japan.

Purpose: To describe CT features of parathyroid carcinomas (PCs) by comparison with benign parathyroid lesions (BPs).

Methods: This retrospective study comprised 82 patients with 76 BPs (62 adenomas and 14 hyperplastic lesions) and 6 PCs. CT features (size, short-to-long axis ratio, shape, peritumoral infiltration, homogeneity, calcification, attenuation values on unenhanced CT, and contrast enhancement during arterial and venous phases) were compared between PCs and BPs. Read More

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http://dx.doi.org/10.1007/s11604-019-00825-3DOI Listing

Incidental diagnosis of breast cancer in the pursuit of the treatment of intestinal obstruction.

Autops Case Rep 2019 Jan-Mar;9(1):e2018071. Epub 2019 Feb 25.

Instituto Português de Oncologia do Porto, Surgical Oncology. Porto, Portugal.

Intestinal lipomatosis is rare and often asymptomatic but can present with intestinal obstruction. Occasionally, metastatic breast cancer is identified in the ovary before a breast primary is discovered. We report the case of a 50-year-old woman diagnosed with synchronous intestinal obstruction due to lipomatosis, and incidental ovarian metastases from breast cancer. Read More

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http://www.autopsyandcasereports.org/article/doi/10.4322/acr
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http://dx.doi.org/10.4322/acr.2018.071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394361PMC
February 2019
1 Read

Accuracy of Distinguishing Atypical Ductal Hyperplasia From Ductal Carcinoma In Situ With Convolutional Neural Network-Based Machine Learning Approach Using Mammographic Image Data.

AJR Am J Roentgenol 2019 Mar 12:1-6. Epub 2019 Mar 12.

4 Department of Medical Physics, Columbia University Medical Center, New York, NY.

Objective: The purpose of this study was to test the hypothesis that convolutional neural networks can be used to predict which patients with pure atypical ductal hyperplasia (ADH) may be safely monitored rather than undergo surgery.

Materials And Methods: A total of 298 unique images from 149 patients were used for our convolutional neural network algorithm. A total of 134 images from 67 patients with ADH that had been diagnosed by stereotactic-guided biopsy of calcifications but had not been upgraded to ductal carcinoma in situ or invasive cancer at the time of surgical excision. Read More

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http://dx.doi.org/10.2214/AJR.18.20250DOI Listing

Diffusion-weighted Imaging of Invasive Breast Cancer: Relationship to Distant Metastasis-free Survival.

Radiology 2019 Mar 12:181706. Epub 2019 Mar 12.

From the Department of Radiology (J.Y.K., J.J.K., L.H.) and Busan Cancer Center (T.K., H.P.), Pusan National University Hospital, 1-10 Ami-Dong, Seo-gu, Busan 602-739, Republic of Korea; and Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea (J.Y.K.).

Background Combined minimum apparent diffusion coefficient (ADC) and ADC difference value may improve the diagnostic performance of breast diffusion-weighted imaging (DWI) compared with mean ADC. Purpose To investigate whether ADC parameters at DWI are associated with distant metastasis-free survival in women with invasive breast cancer. Materials and Methods Between 2013 and 2014, 258 consecutive women (mean age ± standard deviation, 50. Read More

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http://dx.doi.org/10.1148/radiol.2019181706DOI Listing

Magnetization Transfer MRI of Breast Cancer in the Community Setting: Reproducibility and Preliminary Results in Neoadjuvant Therapy.

Tomography 2019 Mar;5(1):44-52

Department of Diagnostic Medicine.

Repeatability and reproducibility of magnetization transfer magnetic resonance imaging of the breast, and the ability of this technique to assess the response of locally advanced breast cancer to neoadjuvant therapy (NAT), are determined. Reproducibility scans at 3 different 3 T scanners, including 2 scanners in community imaging centers, found a 16.3% difference (n = 3) in magnetization transfer ratio (MTR) in healthy breast fibroglandular tissue. Read More

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http://dx.doi.org/10.18383/j.tom.2018.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403021PMC

Development and Validation of Nomograms Predictive of Axillary Nodal Status to Guide Surgical Decision-Making in Early-Stage Breast Cancer.

J Cancer 2019 29;10(5):1263-1274. Epub 2019 Jan 29.

Department of Medical Imaging, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.

: To develop and validate nomogram models using noninvasive imaging parameters with related clinical variables to predict the extent of axillary nodal involvement and stratify treatment options based on the essential cut-offs for axillary surgery according to the ACOSOG Z0011 criteria. : From May 2007 to December 2017, 1799 patients who underwent preoperative breast and axillary magnetic resonance imaging (MRI) were retrospectively studied. Patients with data on axillary ultrasonography (AUS) were enrolled. Read More

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http://www.jcancer.org/v10p1263.htm
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http://dx.doi.org/10.7150/jca.32386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400691PMC
January 2019
1 Read

F-Fluoroestradiol Positron Emission Tomography Imaging of Activating Estrogen Receptor Alpha Mutations in Breast Cancer.

J Nucl Med 2019 Mar 8. Epub 2019 Mar 8.

University of Wisconsin-Madison, United States.

The purpose of this study was to determine the effect of estrogen receptor alpha gene (ESR1) mutations at the tyrosine (Y) 537 amino acid residue within the ligand binding domain on F-fluoroestradiol (F-FES) binding and in vivo tumor uptake compared to wild-type (WT)-estrogen receptor alpha (ER). ER-negative MDA-MB-231 breast cancer cells were used to generate stable cell lines that express WT-ER, Y537S, or Y537C mutant ER. Receptor expression and localization were confirmed by Western blot and immunofluorescence, respectively. Read More

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http://dx.doi.org/10.2967/jnumed.118.224667DOI Listing
March 2019
1 Read

Proton MR spectroscopy in the breast: Technical innovations and clinical applications.

J Magn Reson Imaging 2019 Mar 7. Epub 2019 Mar 7.

Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Proton magnetic resonance spectroscopy (MRS) is a promising noninvasive diagnostic technique for investigation of breast cancer metabolism. Spectroscopic imaging data may be obtained following contrast-enhanced MRI by applying the point-resolved spectroscopy sequence (PRESS) or the stimulated echo acquisition mode (STEAM) sequence from the MR voxel encompassing the breast lesion. Total choline signal (tCho) measured in vivo using either a qualitative or quantitative approach has been used as a diagnostic test in the workup of malignant breast lesions. Read More

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http://dx.doi.org/10.1002/jmri.26700DOI Listing

Diagnostic accuracy and safety of 16α-[F]fluoro-17β-oestradiol PET-CT for the assessment of oestrogen receptor status in recurrent or metastatic lesions in patients with breast cancer: a prospective cohort study.

Lancet Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. Electronic address:

Background: A biopsy of first recurrence or metastatic disease is recommended to re-evaluate oestrogen receptor status in patients with breast cancer and to select appropriate treatment. However, retesting for oestrogen receptor status with rebiopsy is not always feasible, depending on lesion location and the risk associated with biopsy, and in these cases clinicians continue to treat patients according to the oestrogen receptor status of the primary tumour. Consequently suboptimal therapy might be offered to these patients. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30936-7DOI Listing

Comparison of ultrasound and digital mammography plus tomosynthesis in determining benign and malignant breast lesions using pathology as a gold standard, in 102 Chinese women.

Hell J Nucl Med 2019 Mar 5. Epub 2019 Mar 5.

Department of Radiology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College No.17, Pan Jia Yuan Nan-li, PO Box 2258, Beijing 100021, China.

Objective: This study was to evaluate performance characteristics of ultrasonography (US) and a combined two-and three-dimensional (2D+3D) digital mammography in identifying breast tumors in Chinese women.

Subjects And Methods: One hundred and two women with suspected breast tumors were examined using diagnostic imaging techniques of US and a combined 2D+3D imaging protocol. Detection of breast tumors in women with and without dense breasts was validated according to the features of image-detected breast tumors which were proven by histological exam in this study cohort. Read More

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http://dx.doi.org/10.1967/s002449910957DOI Listing

Cypate and cypate-glucosamine as near infrared (NIR) fluorescent probes for in vivo tumor imaging.

Mol Pharmacol 2019 Mar 6. Epub 2019 Mar 6.

University of Central Florida

Near infrared (NIR) imaging is a rapidly developing technique with promising use as a non-invasive, specific and sensitive diagnostic tool. While the NIR fluorescently labeled glucose analog, glucosamine (cypate-glucosamine), has been used for imaging purposes, the transport pathways and fate of this probe in tissues remain unaddressed. Here, we synthesized and characterized cypate and cypate-glucosamine conjugate (cy-2-glu), and investigated the probable transport pathways of these probes in vitro and in vivo. Read More

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http://dx.doi.org/10.1124/mol.118.114199DOI Listing
March 2019
3 Reads

Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses.

Anticancer Res 2019 Mar;39(3):1343-1346

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany

Background/aim: The interval between diagnostic imaging and whole-brain radiotherapy (WBRT) had no significant impact on survival in our previous study of WBRT for brain metastases. Since median survival time was only 2 months, a potentially negative impact by delaying treatment could have been missed. Therefore, we performed an additional analysis of patients surviving at least 4 months following irradiation. Read More

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http://dx.doi.org/10.21873/anticanres.13247DOI Listing

Granular cell tumour in male breast mimicking breast carcinoma.

BMJ Case Rep 2019 Mar 5;12(3). Epub 2019 Mar 5.

Department of Radiology, VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.

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http://dx.doi.org/10.1136/bcr-2018-227805DOI Listing

Radiomics of multi-parametric MRI for pretreatment prediction of pathological complete response to neoadjuvant chemotherapy in breast cancer: a multicenter study.

Clin Cancer Res 2019 Mar 6. Epub 2019 Mar 6.

Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Institute of Automation, Chinese Academy of Sciences

Purpose: We evaluated the performance of the newly proposed radiomics of multi-parametric magnetic resonance imaging (MRI) (hereafter RMM), developed and validated based on a multicenter dataset adopting a radiomic strategy, for pretreatment prediction of pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer.

Methods And Materials: A total of 586 potentially eligible patients were retrospectively enrolled from 4 hospitals (primary cohort and external validation cohort 1~3). Quantitative imaging features were extracted from T2-weighted imaging, diffusion-weighted imaging, and contrast enhanced T1-weighted imaging before NAC for each patient. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3190DOI Listing

A comparison of mid-infrared spectral regions on accuracy of tissue classification.

Analyst 2019 Mar 6. Epub 2019 Mar 6.

Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA. and Departments of Mechanical Science and Engineering, Electrical and Computer Engineering, Chemical and Biomolecular Engineering, and Chemistry, Cancer Center at Illinois, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Infrared (IR) spectroscopic imaging, utilizing both the molecular and structural disease signatures, enables extensive profiling of tumors and their microenvironments. Here, we examine the relative merits of using either the fingerprint or the high frequency regions of the IR spectrum for tissue histopathology. We selected a complex model as a test case, evaluating both stromal and epithelial segmentation for various breast pathologies. Read More

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http://xlink.rsc.org/?DOI=C8AN01782D
Publisher Site
http://dx.doi.org/10.1039/c8an01782dDOI Listing
March 2019
1 Read

Exploiting heat shock protein expression to develop a non-invasive diagnostic tool for breast cancer.

Sci Rep 2019 Mar 5;9(1):3461. Epub 2019 Mar 5.

Department of Biomedical Engineering, Duke University, Durham, NC, USA.

Leveraging the unique surface expression of heat shock protein 90 (Hsp90) in breast cancer provides an exciting opportunity to develop rapid diagnostic tests at the point-of-care setting. Hsp90 has previously been shown to have elevated expression levels across all breast cancer receptor subtypes. We have developed a non-destructive strategy using HS-27, a fluorescently-tethered Hsp90 inhibitor, to assay surface Hsp90 expression on intact tissue specimens and validated our approach in clinical samples from breast cancer patients across estrogen receptor positive, Her2-overexpressing, and triple negative receptor subtypes. Read More

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http://dx.doi.org/10.1038/s41598-019-40252-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400939PMC
March 2019
1 Read
5.078 Impact Factor

A comparative study based on deformable image registration of the target volumes for external-beam partial breast irradiation defined using preoperative prone magnetic resonance imaging and postoperative prone computed tomography imaging.

Radiat Oncol 2019 Mar 5;14(1):38. Epub 2019 Mar 5.

Department of Medical Imaging, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong province, China.

Background: To explore the differences and correlations between the target volumes defined using preoperative prone diagnostic magnetic resonance imaging (MRI) and postoperative prone computed tomography (CT) simulation imaging based on deformable image registration (DIR) for external-beam partial breast irradiation (EB-PBI) after breast-conserving surgery (BCS).

Methods: Eighteen breast cancer patients suitable for EB-PBI were enrolled. Preoperative prone diagnostic MRI and postoperative prone CT scan sets for all the patients were acquired during free breathing. Read More

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http://dx.doi.org/10.1186/s13014-019-1244-xDOI Listing
March 2019
1 Read
2.546 Impact Factor

Alveolar soft part sarcoma metastatic to the breast: a case report.

BMC Surg 2019 Mar 4;19(1):30. Epub 2019 Mar 4.

Department of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan.

Background: Alveolar soft part sarcoma (ASPS) is an extremely rare neoplasm that tends to occur in the lower limbs of children and adolescents. Metastatic breast tumors constitute 0.5-2. Read More

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http://dx.doi.org/10.1186/s12893-019-0494-8DOI Listing
March 2019
1 Read

Vulnerable And Less Vulnerable Women In High-Deductible Health Plans Experienced Delayed Breast Cancer Care.

Health Aff (Millwood) 2019 Mar;38(3):408-415

Dennis Ross-Degnan is an associate professor in the Department of Population Medicine at Harvard Medical School and the Harvard Pilgrim Health Care Institute.

The effects of high-deductible health plans (HDHPs) on breast cancer diagnosis and treatment among vulnerable populations are unknown. We examined time to first breast cancer diagnostic testing, diagnosis, and chemotherapy among a group of women whose employers switched their insurance coverage from health plans with low deductibles ($500 or less) to plans with high deductibles ($1,000 or more) between 2004 and 2014. Primary subgroups of interest comprised 54,403 low-income and 76,776 high-income women continuously enrolled in low-deductible plans for a year and then up to four years in HDHPs. Read More

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http://dx.doi.org/10.1377/hlthaff.2018.05026DOI Listing

Comparison of resection margins and cosmetic outcome following intraoperative ultrasound-guided excision versus conventional palpation-guided breast conservation surgery in breast cancer: A randomized controlled trial.

Indian J Cancer 2018 Oct-Dec;55(4):361-365

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Use of intraoperative ultrasound (IOUS) has been shown to help achieve satisfactory cosmesis and negative margins in breast conserving surgery (BCS). This study has been done to compare the oncological and cosmetic outcomes following BCS using conventional palpatory method and IOUS.

Materials And Methods: This is a prospective randomized controlled trial conducted at a tertiary care teaching and research institute in India. Read More

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http://dx.doi.org/10.4103/ijc.IJC_2_18DOI Listing
March 2019
2 Reads

Improvement of Cancer Detection on Mammograms via BREAST Test Sets.

Acad Radiol 2019 Feb 27. Epub 2019 Feb 27.

Medical Image Optimization and Perception (MIOPeG), Faculty of Health Sciences, University of Sydney, Australia, Room M511, 75 East Street, Lidcombe NSW 2141, Australia.

Background: Breast Screen Reader Assessment Strategy (BREAST) is an innovative training and research program for radiologists in Australia and New Zealand. The aim of this study is to evaluate the efficacy of BREAST test sets in improving readers' performance in detecting cancers on mammograms.

Materials And Methods: Between 2011 and 2018, 50 radiologists (40 fellows, 10 registrars) completed three BREAST test sets and 17 radiologists completed four test sets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10766332193001
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http://dx.doi.org/10.1016/j.acra.2018.12.017DOI Listing
February 2019
2 Reads

Use of the Patent Blue and Air in the Preoperative Marking of Impalpable Breast Lesions.

Eur J Breast Health 2019 Jan 19;15(1):7-12. Epub 2018 Dec 19.

Health Sciences Center, Universidade Federal do Piauí, Teresina, Brazil.

Objective: The goal of this study is to analyze the applicability of the patent blue dye and air in the preoperative marking of impalpable mammary lesions with indication of surgical resection.

Materials And Methods: A prospective cohort study was performed. We selected 49 patients with detection of impalpable lesions on a breast mammography or breast ultrasonography. Read More

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http://dx.doi.org/10.5152/ejbh.2018.4321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385726PMC
January 2019

Evaluation of L-1-[F]Fluoroethyl-Tryptophan for PET Imaging of Cancer.

Mol Imaging Biol 2019 Feb 27. Epub 2019 Feb 27.

Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Purpose: Fluorine-18 labeled tryptophan analog L-1-[F]fluoroethyl-tryptophan (L-1-[F]FETrp) was designed for positron emission tomography (PET) imaging of cancer by dual targeting of the overexpressed amino acid transporters and altered indoleamine 2,3-dioxygenase (IDO)-mediated kynurenine pathway of tryptophan metabolism. In our previous study, we described the radiosynthesis and preliminary evaluation of L-1-[F]FETrp for PET imaging of breast cancer. The aim of this study was to investigate the in vivo imaging mechanism and further evaluate this radiotracer in more wide range types of cancers including prostate cancer, lung cancer, and glioma. Read More

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http://dx.doi.org/10.1007/s11307-019-01327-4DOI Listing
February 2019
1 Read

Hematologic Malignancies of the Breast: A Contemporary Series Investigating Incidence, Presentation, Accuracy of Diagnosis on Core Needle Biopsy, and Hormone Receptor Expression.

Breast Cancer (Auckl) 2019 21;13:1178223419830982. Epub 2019 Feb 21.

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Distinguishing breast hematologic malignancies in core needle biopsies from other entities can be challenging. Misclassification as a breast carcinoma could result in inappropriate treatment. The aim of this study was to characterize the types, incidence, and helpful diagnostic features of hematologic malignancies of the breast. Read More

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http://dx.doi.org/10.1177/1178223419830982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385330PMC
February 2019

Diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping as a quantitative imaging biomarker for prediction of immunohistochemical receptor status, proliferation rate, and molecular subtypes of breast cancer.

J Magn Reson Imaging 2019 Feb 27. Epub 2019 Feb 27.

Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background: Diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping is one of the most useful additional MRI parameters to improve diagnostic accuracy and is now often used in a multiparameric imaging setting for breast tumor detection and characterization.

Purpose: To evaluate whether different ADC metrics can also be used for prediction of receptor status, proliferation rate, and molecular subtype in invasive breast cancer.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.26697DOI Listing
February 2019
1 Read

Edema Fluid Can Be Successfully Evacuated from the Lymphedematous Limbs by Implantation of Silicone Tubings Bypassing the Site of Flow Obstruction Long-Term Observations.

Lymphat Res Biol 2019 Feb 27. Epub 2019 Feb 27.

3 Cardiovascular Clinic, Ahmedabad, India.

Background: Lymphedema of limbs is caused by partial or total obstruction of lymphatic collectors. In advanced cases all main lymphatics are obstructed and tissue fluid accumulates in the interstitial spaces. The microsurgical lympho-venous shunts cannot be performed. Read More

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http://dx.doi.org/10.1089/lrb.2018.0042DOI Listing
February 2019
1 Read

MiR-454-3p-Mediated Wnt/β-catenin Signaling Antagonists Suppression Promotes Breast Cancer Metastasis.

Theranostics 2019 1;9(2):449-465. Epub 2019 Jan 1.

Affiliated Cancer Hospital & Institute of Guangzhou Medical University; Key Laboratory of Protein Modification and Degradation; State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

The Wnt/β-catenin pathway is constitutively active and promotes multiple tumor processes, including breast cancer metastasis. However, the underlying mechanism by which the Wnt/β-catenin pathway is constitutively activated in breast cancer metastasis remains unclear. Inhibition of Wnt antagonists is important for Wnt/β-catenin signaling activation, and post-transcriptional regulation of these antagonists by microRNAs (miRNAs) might be a possible mechanism underlying signaling activation. Read More

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http://dx.doi.org/10.7150/thno.29055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376193PMC
January 2019
7.827 Impact Factor

Double reading of automated breast ultrasound with digital mammography or digital breast tomosynthesis for breast cancer screening.

Clin Imaging 2019 Jan 23;55:119-125. Epub 2019 Jan 23.

Massachusetts General Hospital, Department of Radiology, 15 Parkman St., Boston, MA 02114, United States of America.

Purpose: To evaluate the impact of double reading automated breast ultrasound (ABUS) when added to full field digital mammography (FFDM) or digital breast tomosynthesis (DBT) for breast cancer screening.

Methods: From April 2014 to June 2015, 124 women with dense breasts and intermediate to high breast cancer risk were recruited for screening with FFDM, DBT, and ABUS. Readers used FFDM and DBT in clinical practice and received ABUS training prior to study initiation. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.01.019DOI Listing
January 2019
1 Read

Value of Three-Dimensional Ultrasound in Differentiating Malignant From Benign Breast Tumors: A Systematic Review and Meta-Analysis.

Ultrasound Q 2019 Mar;35(1):68-73

Department of General Practice, Guangxi Medical University, Nanning, Guangxi, China.

Currently, the aim of differentiating malignant from benign breast tumors and diagnosing early breast cancer is more accurately fulfilled with the addition of ultrasound (US) scans. Some studies have shown that three-dimensional (3D) imaging opens a new diagnostic window because of a better and more detailed impression of the spatial arrangement of focal breast masses. Therefore, we carried out this study to assess the efficacy of 3D-US diagnostic techniques for the detection of breast cancer using systemic analyses. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000433DOI Listing

The lncRNA UNC5B-AS1 promotes proliferation, migration, and invasion in papillary thyroid cancer cell lines.

Hum Cell 2019 Feb 25. Epub 2019 Feb 25.

Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.

The incidence of thyroid cancer detection is continually improving worldwide with the spread of diagnostic imaging and surveillance. Although we have made great progress, there are still unknown mechanisms of papillary thyroid cancer. We found that UNC5B-AS1 is a potential oncogene in thyroid cancer. Read More

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http://dx.doi.org/10.1007/s13577-019-00242-8DOI Listing
February 2019

Ultrasound-targeted microbubble destruction improved the antiangiogenic effect of Endostar in triple-negative breast carcinoma xenografts.

J Cancer Res Clin Oncol 2019 Feb 25. Epub 2019 Feb 25.

Department of Ultrasound, Affiliated Union Hospital of Fujian Medical University, Fuzhou, China.

Purpose: Ultrasound-targeted microbubble destruction (UTMD) has been reported to be a meritorious technique for drug targeting delivery. In this study, we aimed to evaluate the synergistic antiangiogenic effect of UTMD combined with Endostar on triple-negative breast carcinoma tumors.

Materials And Methods: The lipid-shelled microbubbles (MBs) conjugated with Endostar were constructed using a biotin-avidin bridging chemistry method, and the morphological characteristics and drug-conjugating content were determined. Read More

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http://dx.doi.org/10.1007/s00432-019-02866-7DOI Listing
February 2019
3.081 Impact Factor

Radiologists’ Performance at Reduced Recall Rates in Mammography: A Laboratory Study

Asian Pac J Cancer Prev 2019 Feb 26;20(2):537-543. Epub 2019 Feb 26.

Medical Image Optimisation and Perception Group (MIOPeG), Discipline of Medical Radiation Sciences, Faculty of Health Sciences, The University of Sydney, Lidcombe NSW, Australia.

Rationale and objectives: Target recall rates are often used as a performance indicator in mammography screening programs with the intention of reducing false positive decisions, over diagnosis and anxiety for participants. However, the relationship between target recall rates and cancer detection is unclear, especially when readers are directed to adhere to a predetermined rate. The purpose of this study was to explore the effect of setting different recall rates on radiologist’s performance. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.537DOI Listing
February 2019

Deep Learning Applications in Chest Radiography and Computed Tomography: Current State of the Art.

J Thorac Imaging 2019 Mar;34(2):75-85

Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center.

Deep learning is a genre of machine learning that allows computational models to learn representations of data with multiple levels of abstraction using numerous processing layers. A distinctive feature of deep learning, compared with conventional machine learning methods, is that it can generate appropriate models for tasks directly from the raw data, removing the need for human-led feature extraction. Medical images are particularly suited for deep learning applications. Read More

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http://dx.doi.org/10.1097/RTI.0000000000000387DOI Listing

Benign Breast Tumours - Diagnosis and Management.

Breast Care (Basel) 2018 Dec 14;13(6):403-412. Epub 2018 Dec 14.

Department of Gynecology and Obstetrics, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany.

With improvements in breast imaging, mammography, ultrasound and minimally invasive interventions, the detection of early breast cancer, non-invasive cancers, lesions of uncertain malignant potential, and benign lesions has increased. However, with the improved diagnostic capabilities comes a substantial risk of false-positive benign lesions and vice versa false-negative malignant lesions. A statement is provided on the manifestation, imaging, and diagnostic verification of isolated benign breast tumours that have a frequent manifestation, in addition to general therapy management recommendations. Read More

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http://dx.doi.org/10.1159/000495919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381897PMC
December 2018
2 Reads

Ultrasound-guided fine-needle aspiration biopsy of thyroid nodules <10 mm in the maximum diameter: does size matter?

Cancer Manag Res 2019 7;11:1231-1236. Epub 2019 Feb 7.

Department of Ultrasound, Ningbo Medical Center Lihuili Eastern Hospital, Ningbo 315040, Zhejiang, China,

Objective: Ultrasound-guided fine-needle aspiration biopsy (US-FNAB) is a safe and effective method of screening malignant thyroid nodules such as papillary thyroid carcinoma. However, not much data are available regarding the diagnostic efficacy of US-FNAB for papillary thyroid microcarcinoma (≤10 mm in diameter). We aim to compare the diagnostic efficacy of US-FNAB on thyroid nodules between two groups divided by a diameter of 10 mm by correlating the cytological results of US-FNAB with the histopathologic diagnoses in selected patients. Read More

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http://dx.doi.org/10.2147/CMAR.S189358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369843PMC
February 2019
1 Read

Value of Axillary Ultrasound after Negative Axillary MRI for Evaluating Nodal Status in High-Risk Breast Cancer.

J Am Coll Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Surgery, Mayo Clinic Florida, Jacksonville, FL. Electronic address:

Background: It is assumed axillary ultrasound (AxUS) is the best method for axillary nodal evaluation in newly diagnosed breast cancer patients. However, few have evaluated the efficacy of preoperative axillary MRI. Herein, we compare the statistical accuracy of AxUS and MRI in detecting nodal metastases among breast cancer patients who were selected for neoadjuvant chemotherapy. Read More

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http://dx.doi.org/10.1016/j.jamcollsurg.2019.01.022DOI Listing
February 2019
1 Read
5.122 Impact Factor

The Results of Surveillance Imaging After Breast Conservation Surgery and Partial Breast Reconstruction With Chest Wall Perforator Flaps; A Qualitative Analysis Compared With Standard Breast-Conserving Surgery for Breast Cancer.

Clin Breast Cancer 2019 Jan 31. Epub 2019 Jan 31.

Department of Breast Surgery, Oxford University Hospitals NHS Trust, Oxford, United Kingdom. Electronic address:

Introduction: Partial breast reconstruction (PBR) using chest wall perforator flaps (CWPF) allows for excision of tumors in the outer quadrant of the breast in women with small to moderate non-ptotic breasts resulting in a good aesthetic outcome. There are limited data available in the literature regarding long-term follow-up and the effect of CWPF on subsequent surveillance mammographic interpretation and recall rates. A retrospective audit with qualitative analysis of initial mammograms was performed to assess this. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.01.010DOI Listing
January 2019

Locoregional cancer recurrence after breast reconstruction: detection, management, and secondary reconstructive strategies.

Plast Reconstr Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania.

Purpose: Locoregional recurrence (LRR) of the previously reconstructed breast poses a diagnostic and operative challenge. This study examines detection, management, and reconstructive strategies of LRR following post-mastectomy breast reconstruction.

Methods: A retrospective review of records was performed on patients treated within the health system for breast cancer from January 2000 - July 2014. Read More

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http://dx.doi.org/10.1097/PRS.0000000000005522DOI Listing
February 2019

Amyloid tumor of the breast.

Surg Case Rep 2019 Feb 19;5(1):31. Epub 2019 Feb 19.

Department of Breast Oncology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.

Background: Amyloid tumor of the breast is a rare disease, which was first reported in 1973. To date, only six cases have been reported in Japan.

Case Presentation: A 45-year-old woman who had a medical history of Sjogren's syndrome presented with a lump of 3 cm in diameter on the outer side of the right breast. Read More

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http://dx.doi.org/10.1186/s40792-019-0591-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381191PMC
February 2019
1 Read

Analysis of the causes of false negative and false positive results of preoperative axillary ultrasound in patients with early breast cancer - a single-centre study.

Contemp Oncol (Pozn) 2018 31;22(4):247-251. Epub 2018 Dec 31.

Chair and Department of Surgical Oncology, Ludwik Rydygier's Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Introduction: Properly planned and performed diagnostic tests allow the optimal treatment option to be chosen for the patient. They also allow qualification for the correct surgical procedure.

Aim Of The Study: In this study we evaluated the clinical value of preoperative ultrasound scan (USS) testing performed during primary disease staging in patients with early breast cancer qualified to sentinel lymph node biopsy (SLNB). Read More

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http://dx.doi.org/10.5114/wo.2018.82644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377422PMC
December 2018
1 Read

Imaging Characteristics of Liver Metastases Overlooked at Contrast-Enhanced CT.

AJR Am J Roentgenol 2019 Feb 19:1-6. Epub 2019 Feb 19.

1 Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Objective: The purpose of this study was to evaluate the imaging characteristics of liver metastases overlooked at contrast-enhanced CT.

Materials And Methods: The records of 746 patients with a diagnosis of liver metastases from colorectal, breast, gastric, or lung cancer between November 2010 and September 2017 were reviewed. Images were reviewed when liver metastases were first diagnosed, and images from prior contrast-enhanced CT examinations were checked if available. Read More

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http://dx.doi.org/10.2214/AJR.18.20526DOI Listing
February 2019
1 Read

Impact of Artificial Intelligence on Women's Imaging: Cost-Benefit Analysis.

AJR Am J Roentgenol 2019 Feb 19:1-2. Epub 2019 Feb 19.

1 Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1350, Houston, TX 77030-4009.

Objective: The purpose of this article is to identify and discuss four areas in which artificial intelligence (AI) must excel to become clinically viable: performance, time, work flow, and cost.

Conclusion: AI holds tremendous potential for transforming the practice of radiology, but certain metrics are needed to objectively quantify its impact. As patients, physicians, hospitals, and insurance companies look for value, AI must earn a role in medical imaging. Read More

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http://dx.doi.org/10.2214/AJR.18.20419DOI Listing
February 2019
1 Read

Surgical treatment of rectal cancer with a Retzius shunt: a case report.

Surg Case Rep 2019 Feb 18;5(1):25. Epub 2019 Feb 18.

Department of Surgery, Osaka Rosai Hospital, 1179-3 Nagasonecho, Kita-ku, Sakai, 591-8025, Japan.

Background: A case of a short circuit (Retzius shunt) from the inferior mesenteric vein (IMV) to the inferior vena cava (IVC) without accompanying portal hypertension due to liver cirrhosis is rare.

Case Presentation: An 83-year-old woman who was followed after surgery for thyroid and breast cancer was incidentally found to have rectal cancer on computed tomography (CT). Preoperative three-dimensional CT showed a venous malformation forming a short circuit (Retzius shunt) from the IMV to the IVC. Read More

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http://dx.doi.org/10.1186/s40792-019-0583-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379499PMC
February 2019
3 Reads

Whole slide imaging equivalency and efficiency study: experience at a large academic center.

Mod Pathol 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Memorial Sloan Kettering, New York, NY, USA.

Whole slide imaging is Food and Drug Administration-approved for primary diagnosis in the United States of America; however, relatively few pathology departments in the country have fully implemented an enterprise wide digital pathology system enabled for primary diagnosis. Digital pathology has significant potential to transform pathology practice with several published studies documenting some level of diagnostic equivalence between digital and conventional systems. However, whole slide imaging also has significant potential to disrupt pathology practice, due to the differences in efficiency of manipulating digital images vis-à-vis glass slides, and studies on the efficiency of actual digital pathology workload are lacking. Read More

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http://www.nature.com/articles/s41379-019-0205-0
Publisher Site
http://dx.doi.org/10.1038/s41379-019-0205-0DOI Listing
February 2019
3 Reads

Digital Mammography versus Digital Mammography Plus Tomosynthesis in Breast Cancer Screening: The Oslo Tomosynthesis Screening Trial.

Radiology 2019 Feb 19:182394. Epub 2019 Feb 19.

From the Division of Radiology and Nuclear Medicine, Oslo University Hospital, University of Oslo, Breast Imaging Center, PO Box 4950, Nydalen, 0424 Oslo, Norway (P.S., R.G.); Departments of Biostatistics (A.I.B.) and Radiology (D.G.), University of Pittsburgh, Pittsburgh, Pa; Retired, former employee of Hologic (L.T.N.); Department of Screening, Cancer Registry of Norway, Oslo, Norway (S.S., S.H.); Department of Diagnostic Physics, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway (B.H.Ø.); and Department of Health Sciences, Oslo Metropolitan University, Oslo, Norway (S.H.).

Background Digital breast tomosynthesis (DBT) is replacing digital mammography (DM) in the clinical workflow. Currently, there are limited prospective studies comparing the diagnostic accuracy of both examinations and the role of synthetic mammography (SM) and computer-aided detection (CAD). Purpose To compare the accuracy of DM versus DM + DBT in population-based breast cancer screening. Read More

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http://dx.doi.org/10.1148/radiol.2019182394DOI Listing
February 2019