Search Our Scientific Publications & Authors

J Digit Imaging 2019 Apr 22. Epub 2019 Apr 22.

Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY, 10065, USA.

To determine whether cmAssist™, an artificial intelligence-based computer-aided detection (AI-CAD) algorithm, can be used to improve radiologists' sensitivity in breast cancer screening and detection. A blinded retrospective study was performed with a panel of seven radiologists using a cancer-enriched data set from 122 patients that included 90 false-negative mammograms obtained up to 5.8 years prior to diagnosis and 32 BIRADS 1 and 2 patients with a 2-year follow-up of negative diagnosis. Read More

Medicine (Baltimore) 2019 Apr;98(16):e15175

Department of Computed Tomography, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

Background: Previous clinical studies have reported that full field digital mammography (FFDM) can be used for diagnosis on breast cancer (BC) with promising outcome results. However, no study systematically investigates its diagnostic impact on female patients with BC. Thus, this systematic review will assess the accurate of FFDM diagnosis on BC. Read More

EClinicalMedicine 2019 Jan;7:39-46

Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine' Charterhouse Square, London EC1M 6BQ, UK.

Background: Many women who are at increased risk of breast cancer due to a mother or sister diagnosed with breast cancer aged under 40 do not currently qualify for surveillance before 40 years of age. There are almost no available data to assess whether mammography screening aged 35-39 years would be effective in this group, in terms of detection of breast cancer at an early stage or cost effective.

Methods: A cohort screening study (FH02) with annual mammography was devised for women aged 35-39 to assess the sensitivity and screening performance and potential survival of women with identified tumours. Read More

SAGE Open Med Case Rep 2019 9;7:2050313X19841154. Epub 2019 Apr 9.

Department of the Health of Woman, Child and Urological Diseases, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.

A 74-year-old female patient presented with a hard breast mass and dimpling with a clinical suspicion of a carcinoma. Histological evaluation revealed a granular cell tumour. Granular cell tumour is a rare neoplasm, mostly benign in origin that may arise in every body site, 5%-15% of cases occur in the breast. Read More

Breast Cancer Res Treat 2019 Apr 20. Epub 2019 Apr 20.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY, 10065, USA.

Purpose: Successful breast-conserving surgery (BCS) followed by radiation therapy (XRT) is dependent on complete removal of the cancer with clear surgical margins, providing survival rates equivalent to those observed following mastectomy. In patients who have cancers presenting with microcalcifications, post lumpectomy mammograms (PLM) prior to radiation (XRT) can be performed to ensure that no cancer has been left behind. The purpose of this study was to assess the benefit of PLM in patients with malignant breast tumors presenting with microcalcifications. Read More

Clin Transl Oncol 2019 Apr 20. Epub 2019 Apr 20.

Department of Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin, 150086, Heilongjiang, China.

Background: Breast ultrasound and mammography were used in the detection of residual tumor after neoadjuvant chemotherapy. The aim of this study was to evaluate the correlation between clinical and pathological responses with breast density and IHC marker conversion to understand how this information might be used in the future to direct treatment.

Methods: We included 119 patients who underwent CNB and followed NACT. Read More

Eur J Radiol 2019 May 21;114:175-184. Epub 2019 Mar 21.

Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands. Electronic address:

Purpose: To develop and validate an interpretable and repeatable machine learning model approach to predict molecular subtypes of breast cancer from clinical metainformation together with mammography and MRI images.

Methods: We retrospectively assessed 363 breast cancer cases (Luminal A 151, Luminal B 96, HER2 76, and BLBC 40). Eighty-two features defined in the BI-RADS lexicon were visually described. Read More

Eur J Radiol 2019 May 21;114:167-174. Epub 2019 Mar 21.

Department of Diagnostic Radiology, Unit 1350, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. Electronic address:

Objective: Different molecular subtypes of triple-negative breast cancer (TNBC) have previously been identified through analysis of gene expression profiles. The luminal androgen receptor (LAR) subtype has been shown to have a lower rate of pathologic complete response to neoadjuvant chemotherapy than other TNBC subtypes. The purpose of this study was to determine if the imaging features of TNBCs differ by AR (androgen receptor) status, which is a surrogate immunohistochemical (IHC) marker for the chemoresistant LAR subtype of TNBC. Read More

Int J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1018, Center for Research in Epidemiology and Population Health (CESP), Gustave Roussy, Villejuif, France.

Advanced breast cancer (BC) are is associated with heavier treatments and poorer prognosis than early BC. Despite mammographic screening, advanced BC incidence remains stable. Little is known about risk factors differentially associated with advanced BC. Read More

Int J Cancer 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

Between January 1, 2011 and December 31, 2016 we studied the incidence, management and outcome of high-risk breast lesions in a consecutive series of 376,519 screens of women who received biennial screening mammography. During the 6-year period covered by the study, the proportion of women who underwent core needle biopsy (CNB) following recall remained fairly stable, ranging from 39.2% to 48. Read More

Phys Med 2019 Apr 28;60:66-75. Epub 2019 Mar 28.

Department of Radiotherapy, Institut Bergonié, Comprehensive Cancer Center, 229 cours de l'Argonne, 33076 Bordeaux, France.

Purpose: Breast cancer is the most frequent cancer in women. Early and accurate detection of the disease is a major factor in patient survival. To this end, phase-contrast imaging has gained significant interest in recent years. Read More

Expert Rev Med Devices 2019 Apr 18. Epub 2019 Apr 18.

b Department of Radiology, University of Washington School of Medicine; Department of Health Services , University of Washington School of Public Health; Hutchinson Institute for Cancer Outcomes Research , 1144 Eastlake Avenue East LG-212, Seattle , WA 98109 , USA.

Introduction: Various factors are driving interest in the application of artificial intelligence (AI) for breast cancer (BC) detection, but it is unclear whether the evidence warrants large-scale use in population-based screening. Areas covered: We performed a scoping review, a structured evidence synthesis describing a broad research field, to summarise knowledge on AI evaluated for BC detection and to assess AI's readiness for adoption in BC screening. Studies were predominantly small retrospective studies based on highly selected image datasets that contained a high proportion of cancers (median BC proportion in datasets 26. Read More

Ultrasonography 2018 Dec 23. Epub 2018 Dec 23.

Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: The purpose of this study was to assess the reliability of automated breast ultrasound (ABUS) examinations of suspicious breast masses in comparison to handheld breast ultrasound (HHUS) with regard to Breast Imaging Reporting and Data System (BI-RADS) category assessment, and to investigate the factors affecting discrepancies in categorization.

Methods: A total of 135 masses that were assessed as BI-RADS categories 4 and 5 on ABUS that underwent ultrasound (US)-guided core needle biopsy from May 2017 to December 2017 were included in this study. The BI-RADS categories were re-assessed using HHUS. Read More

Eur J Cancer Prev 2019 Apr 16. Epub 2019 Apr 16.

Psychiatric University Hospital (UPK), University of Basel, Basel.

One in five women will experience depression over her lifetime, and one out of eight will develop breast cancer. We evaluated the effect of depression on adherence to mammography in Switzerland, where opportunistic and organized screening programs coexist. We analyzed data from 3206 women aged 50-69 who participated in the Swiss Health Survey 2012. Read More

J Oncol Pract 2019 Apr 18:JOP1800352. Epub 2019 Apr 18.

1 Brigham and Women's Hospital, Boston, MA.

Purpose: Accountable care organizations (ACOs) are a delivery and payment model designed to encourage integrated, high-value care. We designed a study to test the association between ACOs and two recommended cancer screening tests, colonoscopy for colorectal cancer and mammography for breast cancer.

Methods: Using the random 20% sample of Medicare claims, beneficiaries were attributed to ACO or non-ACO cohorts on the basis of providers' enrollment in the Medicare Shared Savings Program. Read More

AJR Am J Roentgenol 2019 Apr 17:1-4. Epub 2019 Apr 17.

1 Department of Radiology, University Hospitals Cleveland Medical Center, 11100 Euclid Ave, Cleveland, OH 44106.

The purpose of this article is to describe steps for implementing abbreviated breast MRI into a breast imaging practice. Mammographic screening for breast cancer has been the standard of care. However, breast cancer remains a leading cause of death of women. Read More

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload.

Methods And Materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC ROC) studies. An AI system was used to obtain a score between 1 and 10 for each exam, representing the likelihood of cancer present. Read More

Am Fam Physician 2019 Apr;99(8):505-514

Thomas Jefferson University, Philadelphia, PA, USA.

Palpable breast masses, mastalgia, and nipple discharge are commonly encountered symptoms in outpatient practice, causing significant patient anxiety and precipitating medical consultation. The initial workup includes a detailed clinical history and physical examination. Women presenting with a breast mass will require imaging and further assessment to exclude cancer. Read More

Cureus 2019 Feb 3;11(2):e4000. Epub 2019 Feb 3.

Pathology, University of Texas Medical Branch, Galveston, USA.

Background Benign mesenchymal tumors of the breast are rare and may mimic invasive carcinoma on imaging and morphology, thus becoming clinically challenging for clinicians, radiologists, and pathologists. To improve the understanding of these lesions and to avoid erroneous diagnosis and inappropriate treatment, we report our institution's experience with seven cases of granular cell tumor (GCT) and myofibroblastoma (MFB) in the past 10 years. Materials and methods Seven cases of benign mesenchymal tumors of the breast were identified at the University of Texas Medical Branch from 2008 to 2018. Read More

J Womens Health (Larchmt) 2019 Apr 13. Epub 2019 Apr 13.

2 Program for Women's Health Effectiveness Research, University of Michigan, Ann Arbor, Michigan.

Introduction: We assessed changes in screening mammography cost sharing and utilization before and after the Affordable Care Act (ACA) and the revised U.S. Preventive Services Task Force (USPSTF) recommendations by race and income. Read More

J Family Med Prim Care 2019 Feb;8(2):419-425

Department of Family Medicine, Universite Saint Joseph, Beirut.

Introduction: To evaluate the psychosocial impact of benign breast biopsies on Lebanese women after a screening mammography and the effect of these biopsies on patients' attitudes toward subsequent screening.

Methods: In this retrospective study (January 2005 till April 2011), 109 consecutive patients with a history of breast biopsy without cancer were asked to answer a phone questionnaire. The response rate was 91. Read More

Radiologia 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To analyze the imaging characteristics of histologically diagnosed metastases to the breast.

Material And Methods: We selected patients histologically diagnosed with metastases to the breast in our diagnostic and interventional breast imaging unit between March 2010 and September 2018.

Results: A total of 9 patients (all women; mean age, 60 y; age range, 28-89 y) were diagnosed with metastases to the breast. Read More

Breast 2019 Apr 3;46:1-3. Epub 2019 Apr 3.

Brooklyn Law School.

Medical error is a leading cause of preventable death in the U.S., with diagnostic errors comprising the majority of errors. Read More

Breast Cancer 2019 Apr 12. Epub 2019 Apr 12.

Division of Clinical Genetic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake Koto-ku, Tokyo, 135-8550, Japan.

Individuals carrying pathogenic BRCA1 or BRCA2 mutations have an increased lifetime risk of breast and/or ovarian cancer. The incidence of breast cancer amongst disease-free BRCA mutation carriers under surveillance and the clinical and pathological characteristics of those who subsequently develop the disease remain unclear in Japan. We reviewed the records of 155 individuals with BRCA1 or BRCA2 mutations identified by genetic testing between January 2000 and December 2016. Read More

Med Biol Eng Comput 2019 Apr 12. Epub 2019 Apr 12.

Department of Women's Health, Research Centre for Women's Health, 72076, Tübingen, Germany.

In the case of female breast cancer, a breast-conserving excision is often desirable. This surgery is based on preoperatively gathered MRI, mammography, and sonography images. These images are recorded in multiple patient positions, e. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Apr 3;237:1-6. Epub 2019 Apr 3.

Department of General Practice, Faculté de medicine, Université Paris Descartes, Paris, France.

Objectives: The guidelines for breast cancer screening with clinical breast examination (CBE) are diverging CBE is recommended in France, whereas it is not recommended in the United States and Canada, given the lack of clear benefit and the risk of overmedication. To assess the accuracy of abnormalities found during CBE for in breast cancer screening.

Study Design: A cross-sectional study included women over 18 years with no history of breast cancer coming for a mammography at 3 ambulatory radiology practices in Paris. Read More

AJR Am J Roentgenol 2019 Apr 11:1-6. Epub 2019 Apr 11.

1 2Memorial Sloan Kettering Cancer Center, Evelyn H. Lauder Breast Center, 300 E 66th St, New York, NY 10065.

Objective: The purposes of this study were to compile mammographic images in various projections showing commercially available breast biopsy site markers and to provide a standardized nomenclature and marker guide to improve physician communication and patient care.

Materials And Methods: A retrospective review of all breast biopsy markers encountered at one institution was conducted from January 2012 to January 2018. Markers placed at the facility and those placed at outside institutions with the patient subsequently referred to the study institution were included. Read More

Breast J 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology, Dayanand Medical College & Hospital, Ludhiana, India.

Fine needle aspiration cytology has long been an accepted diagnostic modality in combination with physical examination and mammography to investigate breast lesions. In the present era, more proficient methods such as stereotactic mammographically guided breast biopsy is the preferred choice, however, in low resource setting, FNAC still remains the most cost effective and sampling modality to diagnose breast cancer. With the intention to evaluate the efficacy and limitations of FNAC in evaluation of breast lesions in low resource setting, we employed the Masood's cytological staging system to stratify the breast lesions and correlate them with histopathology wherever possible. Read More

Breast Cancer Res Treat 2019 Apr 10. Epub 2019 Apr 10.

Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

Purpose: Since 2012, about 80 specialty societies have released Choosing Wisely (CW) recommendations aimed at reducing the use of low-value, unproven, or ineffective medical services. The extent to which these recommendations have influenced the behavior of physicians and patients remains largely unknown.

Methods: Using MarketScan Commercial Claims and Medicare Supplemental and Coordination of Benefits databases, we identified annual cohorts of women with incident, early-stage breast cancer and estimated the prevalence of four initial treatment and six surveillance metrics deemed as low-value breast cancer care by CW. Read More

BMJ 2019 Apr 10;365:l1293. Epub 2019 Apr 10.

Rochester, Kent, UK

J Cancer Surviv 2019 Apr 9. Epub 2019 Apr 9.

Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Passeig Marítim, 25-29, 08003, Barcelona, Spain.

Purpose: Long-term breast cancer survivors are women surviving at least 5 years after diagnosis. This systematic review aimed to summarize the main characteristics and patterns of healthcare service use (frequency of visits, health providers visited, and preventive care performed) among long-term breast cancer survivors.

Methods: We used standard Cochrane Collaboration methods and searched the MEDLINE and EMBASE databases up to January 2018. Read More

Cancers (Basel) 2019 Apr 8;11(4). Epub 2019 Apr 8.

The Breast Center/Section of Surgical Oncology, Department of Surgery, Yale School of Medicine, New Haven, CT 06520, USA.

: Despite screening mammography, the incidence of Stage IV breast cancer (BC) at diagnosis has not decreased over the past four decades. We previously found that many BCs are small due to favorable biology rather than early detection. This study compared the biology of Stage IV cancers with that of small cancers typically found by screening. Read More

Radiology 2019 Apr 9:182457. Epub 2019 Apr 9.

From the Departments of Medical Imaging (M.F., E.P., I.M., P.T.) and Biostatistics and Medical Information (N.M.), Montpellier University Hospital, Lapeyronie Hospital, 191 avenue du Doyen Gaston Giraud, 34295 Montpellier, France; Department of Medical Imaging, Ramsay Générale de Santé, Hospital Mermoz, Lyon, France (C.T.); Department of Women's Imaging, Centre Hospitalier de Valenciennes, Valenciennes, France (N.L.); and Department of Medical Imaging, ICM (Montpellier Cancer Institute), Montpellier, France (G.L.).

Background Combined digital mammography (DM) and digital breast tomosynthesis (DBT) (hereafter, DM plus DBT) has increased cancer detection rates when compared with those achieved with DM-only screening. However, there is limited literature on DBT as an adjunct to mammography in the staging of known breast cancers. Purpose To compare the diagnostic accuracy of DM alone with that of DM plus DBT in the identification of additional ipsilateral and contralateral lesions in women with newly diagnosed breast cancer. Read More

J Digit Imaging 2019 Apr 8. Epub 2019 Apr 8.

Voxel Imaging, Inc., 2711 N. Sepulveda Blvd., #284, Manhattan Beach, CA, 90266, USA.

The aim was to determine whether an artificial intelligence (AI)-based, computer-aided detection (CAD) software can be used to reduce false positive per image (FPPI) on mammograms as compared to an FDA-approved conventional CAD. A retrospective study was performed on a set of 250 full-field digital mammograms between January 1, 2013, and March 31, 2013, and the number of marked regions of interest of two different systems was compared for sensitivity and specificity in cancer detection. The count of false-positive marks per image (FPPI) of the two systems was also evaluated as well as the number of cases that were completely mark-free. Read More

Open Access Maced J Med Sci 2019 Mar 14;7(5):838-848. Epub 2019 Mar 14.

Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.

One of the techniques utilised in the management of cancer in all stages is multiple biomedical imaging. Imaging as an important part of cancer clinical protocols can provide a variety of information about morphology, structure, metabolism and functions. Application of imaging technics together with other investigative apparatus including in fluids analysis and vitro tissue would help clinical decision-making. Read More

Diagn Interv Imaging 2019 Apr 5. Epub 2019 Apr 5.

"Diagnostic Mammography" Medical Diagnostic Imaging Unit, Kifisias Avenue 362, Chalandri, 15233 Athens, Greece. Electronic address:

Three-dimensional automated breast ultrasound system (3D ABUS) is an innovation in breast ultrasound that has been developed to uncouple detection from image acquisition and to address the limitations of handheld ultrasound (HHUS). 3D ABUS provides a large field of view using high frequency transducers, producing high-resolution images and covering a large portion of the breast with one sweep. As more data become available on breast density and the impact of supplemental screening, 3D ABUS has gained wider acceptance as an adjunct tool to mammography. Read More

Diagn Interv Imaging 2019 Apr 5. Epub 2019 Apr 5.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

Although mammography is currently the imaging technique of choice for screening and diagnosis, it has some limitations, especially in patients with high-density breasts. The evolution from film screen to full-field digital mammography has recently led to the development of new imaging techniques, which are less expensive and widely available. Contrast-enhanced spectral mammography (CESM) is one of them, coupling X-ray breast imaging to the intravenous administration of an iodinated contrast material. Read More

Ann Intern Med 2019 Apr 9. Epub 2019 Apr 9.

Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota (T.J.W.).

Description: The purpose of this guidance statement is to provide advice to clinicians on breast cancer screening in average-risk women based on a review of existing guidelines and the evidence they include.

Methods: This guidance statement is derived from an appraisal of selected guidelines from around the world that address breast cancer screening, as well as their included evidence. All national guidelines published in English between 1 January 2013 and 15 November 2017 in the National Guideline Clearinghouse or Guidelines International Network library were included. Read More

Radiography (Lond) 2019 May 13;25(2):170-177. Epub 2018 Dec 13.

Western Norway University of Applied Sciences (HVL), Norway.

Objectives: To identify the roles of health care staff in interprofessional work related to breast cancer detection and diagnosis.

Key Findings: A comprehensive search was performed using PICO to support inclusion and exclusion criteria. A shortened version of the STROBE checklist ensured evaluation of the studies. Read More

Cancer Causes Control 2019 May 4;30(5):435-441. Epub 2019 Apr 4.

Department of Population Health, New York University School of Medicine, New York, NY, USA.

Many women diagnosed with breast cancer have chronic conditions such as diabetes that may impact other health behaviors. Our purpose was to determine if breast cancer screening and detection differs among women with and without diabetes. We conducted a cross-sectional analysis of a retrospective cohort of women aged 52-74 years diagnosed with incident stages I-III breast cancer enrolled in an integrated health plan between 1999 and 2014 with linkage to the Surveillance, Epidemiology and End Results registry (n = 2040). Read More

J Am Coll Radiol 2019 Apr;16(4 Pt B):631-634

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Purpose: One in five US women report that they have been victims of intimate partner violence (IPV) during their lifetime. With millions of women presenting for mammography every year, breast imaging centers may represent ideal venues to identify women at risk for IPV and refer them to appropriate support services. Our purpose was to evaluate implementation of a novel IPV screening and referral system for women presenting for mammography. Read More

J Am Coll Radiol 2019 Apr;16(4 Pt B):580-585

Department of Radiology, National Jewish Health, Denver, Colorado.

Disparities in outcomes exist for breast, colon, and lung cancer among diverse populations, particularly racial and ethnic underrepresented minorities (URMs) and individuals from lower socioeconomic status. For example, blacks experience mortality rates up to about 42% higher than whites for these cancers. Furthermore, although overall death rates have been declining, the differential access to screening and care has aggravated disparities. Read More

Comput Math Methods Med 2019 3;2019:2717454. Epub 2019 Mar 3.

Medical Imaging Center, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong 518101, China.

Mammography is successfully used as an effective screening tool for cancer diagnosis. A calcification cluster on mammography is a primary sign of cancer. Early researches have proved the diagnostic value of the calcification, yet their performance is highly dependent on handcrafted image descriptors. Read More

Breast Cancer Res 2019 Apr 3;21(1):48. Epub 2019 Apr 3.

General Internal Medicine Section, San Francisco Veterans Affairs Medical Center & Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.

Background: Obesity and elevated breast density are common risk factors for breast cancer, and their effects may vary by estrogen receptor (ER) subtype. However, their joint effects on ER subtype-specific risk are unknown. Understanding this relationship could enhance risk stratification for screening and prevention. Read More

Neoplasma 2019 Mar 31;2019. Epub 2019 Mar 31.

Department of Pathology, St. Elizabeth Cancer Institute, Bratislava, Slovakia.

Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease mimicking carcinoma and puerperal or non-puerperal mastitis. The primary purpose of this prospectively performed case control study was to compare clinical and imaging signs of IGM with the reference group of nonspecific, non- puerperal mastitis (NM) to identify the most typical clinical and imaging signs essential for a correct differential diagnosis. The secondary purpose was to present a new approach to non-invasive treatment. Read More

Radiology 2019 Apr 2:181637. Epub 2019 Apr 2.

From the Department of Radiology (M.B., N.P., C.D.L.), Institute for Technology Assessment (S.M.), and Department of Medicine (A.M.M.), Massachusetts General Hospital, 55 Fruit St, WAC 240, Boston, MA 02114.

Background Although breast cancer incidence and mortality rates increase with advancing age, there are limited data on the benefits and risks of screening mammography in older women and on the performance of two-dimensional digital mammography (DM) and digital breast tomosynthesis (DBT) in older women. Purpose To compare performance metrics of DM and DBT among women aged 65 years and older. Materials and Methods For this retrospective study, consecutive screening mammograms in patients aged 65 years and older from March 2008 to February 2011 (DM group) and from January 2013 to December 2015 (DBT group) were reviewed. Read More

Onco Targets Ther 2019 15;12:2023-2033. Epub 2019 Mar 15.

Department of Breast Oncology, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People's Republic of China,

Background: Microcalcification is a very important diagnostic information in breast cancer. The purpose of this study was to determine the relationship of clinicopathological features and prognosis of breast cancer with microcalcification and to detect biomarkers related to the possible mechanisms of microcalcifications.

Patients And Methods: All 529 subjects with microcalcifications were selected from patients who had been examined using breast mammography. Read More

AJR Am J Roentgenol 2019 Apr 1:1-7. Epub 2019 Apr 1.

9 Diagnostic Imaging, X-Ray Products, Siemens Healthcare GmbH, Forchheim, Germany.

Objective: The purpose of this study was to test the hypothesis whether two-view wide-angle digital breast tomosynthesis (DBT) can replace full-field digital mammography (FFDM) for breast cancer detection.

Subjects And Methods: In a multireader multicase study, bilateral two-view FFDM and bilateral two-view wide-angle DBT images were independently viewed for breast cancer detection in two reading sessions separated by more than 1 month. From a pool of 764 patients undergoing screening and diagnostic mammography, 330 patient-cases were selected. Read More

Br J Radiol 2019 Apr 1:20180245. Epub 2019 Apr 1.

1 Department of Radiology Faculty of Medicine, Kasr El Aini hospital, Cairo University , Egypt.

Objective:: To evaluate the clinical performance of contrast-enhanced spectral mammography (CESM) on asymmetries detected on a mammogram (MG).

Methods:: This study was approved by the Scientific Research Review Board of the Radiology Department, and waiver of informed consent was applied for the uses of data of the included cases. The study included 125 female patients,33 (26. Read More