Search Our Scientific Publications & Authors

Quant Imaging Med Surg 2019 Jan;9(1):63-74

Medical Engineering and Technology Center, Taishan Medical University, Taian 271016, China.

Background: Breast imaging technology plays an important role in breast cancer planning and treatment. Recently, three-dimensional (3D) printing technology has become a trending issue in phantom constructions for medical applications, with its advantages of being customizable and cost-efficient. However, there is no current practice in the field of multi-purpose breast phantom for quality control (QC) in multi-modalities imaging. Read More

Surg Case Rep 2019 Feb 19;5(1):31. Epub 2019 Feb 19.

Department of Breast Oncology, Aichi Cancer Center, 1-1 Kanokoden, Chikusa-ku, Nagoya, 464-8681, Japan.

Background: Amyloid tumor of the breast is a rare disease, which was first reported in 1973. To date, only six cases have been reported in Japan.

Case Presentation: A 45-year-old woman who had a medical history of Sjogren's syndrome presented with a lump of 3 cm in diameter on the outer side of the right breast. Read More

Circulation 2019 Feb;139(8):1094-1101

Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego.

Cardiovascular disease continues to be the leading cause of death among women in the United States. One of the barriers to improving cardiovascular disease outcomes in women is the lack of reliable, effective screening modalities. Breast arterial calcification has emerged as a potential risk stratification tool. Read More

Radiology 2019 Feb 19:182394. Epub 2019 Feb 19.

From the Division of Radiology and Nuclear Medicine, Oslo University Hospital, University of Oslo, Breast Imaging Center, PO Box 4950, Nydalen, 0424 Oslo, Norway (P.S., R.G.); Departments of Biostatistics (A.I.B.) and Radiology (D.G.), University of Pittsburgh, Pittsburgh, Pa; Retired, former employee of Hologic (L.T.N.); Department of Screening, Cancer Registry of Norway, Oslo, Norway (S.S., S.H.); Department of Diagnostic Physics, Institute of Clinical Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway (B.H.Ø.); and Department of Health Sciences, Oslo Metropolitan University, Oslo, Norway (S.H.).

Background Digital breast tomosynthesis (DBT) is replacing digital mammography (DM) in the clinical workflow. Currently, there are limited prospective studies comparing the diagnostic accuracy of both examinations and the role of synthetic mammography (SM) and computer-aided detection (CAD). Purpose To compare the accuracy of DM versus DM + DBT in population-based breast cancer screening. Read More

Am J Surg 2019 Jan 31. Epub 2019 Jan 31.

Diagnostic Imaging Northwest PC, Legacy Good Samaritan Hospital, 1015 N.W. 22nd Ave, Portland, OR, 97210, USA.

Background: Digital breast tomosynthesis (DBT) is a mammographic technique which improves the detection of breast cancer. Architectural distortion of malignancy may be occult on 2D mammography and ultrasound but detected by DBT.

Methods: 110 patients who underwent 116 DBT-guided needle biopsies for architectural distortion were identified between June 2014 and August 2017 and underwent review of medical records. Read More

Acad Radiol 2019 Feb 13. Epub 2019 Feb 13.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Caroline Street, Suite 4120E, Baltimore, MD 21287. Electronic address:

Rationale And Objectives: Our objective was to identify factors impacting false positive recalls in screening mammography.

Materials And Methods: We retrospectively reviewed our screening mammography database from August 31, 2015 to September 30, 2016, including full field digital mammograms (FFDM) and digital breast tomosynthesis (DBT) mammograms. False positive (FP) exams were defined as Breast Imaging-Reporting and Data System (BI-RADS) 1 or 2 assessments at diagnostic imaging with 1 year cancer-free follow-up, Breast Imaging-Reporting and Data System 3 assessment at diagnostic imaging with 2 years cancer free follow-up, or biopsy with benign pathology. Read More

Methods 2019 Feb 13. Epub 2019 Feb 13.

Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, High Education Zone, Hangzhou 310018, China. Electronic address:

Digital breast tomosynthesis (DBT) is a newly developed three-dimensional tomographic imaging modality in the field of breast cancer screening designed to alleviate the limitations of conventional digital mammography-based breast screening methods. A computer-aided detection (CAD) system was designed for masses in DBT using a faster region-based convolutional neural network (faster-RCNN). To this end, a data set was collected, including 89 patients with 105 masses. Read More

Eur Radiol 2019 Feb 15. Epub 2019 Feb 15.

Imaging Department, Gustave Roussy, 114 rue Edouard Vaillant, 94800, Villejuif, France.

Objectives: Radiologists' visual assessment of breast mammographic density (BMD) is subject to inter-observer variability. We aimed to develop and validate a new automated software tool mimicking expert radiologists' consensus assessments of 2D BMD, as per BI-RADS V recommendations.

Methods: The software algorithm was developed using a concept of Manhattan distance to compare a patient's mammographic image to reference mammograms with an assigned BMD category. Read More

Cancer 2019 Feb 15. Epub 2019 Feb 15.

Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.

Background: Patient advocacy has led to state-level legislative mandates for the release of personal mammographic breast density information to women undergoing screening mammography. More research is needed to understand the impact of this information on women's perceptions and mammography screening behavior.

Methods: Semistructured interviews were conducted in English and Spanish with 24 self-identified Hispanic women who had undergone at least 1 mammogram since breast density notification was enacted in New York State. Read More

Gan To Kagaku Ryoho 2019 Jan;46(1):154-156

Dept. of Surgery, Okayama Rosai Hospital.

A 66-year-old woman underwent distal gastrectomy because of gastric cancer(stage ⅠB)and received no adjuvant chemotherapy. Eight years after the operation, computed tomography showed a small nodule in the right breast. Mammography did not reveal any abnormalities. Read More

Int J Cancer 2019 Feb 14. Epub 2019 Feb 14.

Section of Early Detection and Prevention, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, France.

This systematic review, stimulated by inconsistency in secondary evidence, reports the benefits and harms of breast cancer (BC) screening and their determinants according to systematic reviews. A systematic search, which identified 9,976 abstracts, led to the inclusion of 58 reviews. BC mortality reduction with screening mammography was 15-25% in trials and 28-56% in observational studies in all age groups, and the risk of stage III+ cancers was reduced for women older than 49 years. Read More

Int J Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Radiology and Nuclear Medicine, Radboud University, Medical Center, Geert Grooteplein 10, 6525, GA, Nijmegen, the Netherlands.

High mammographic density is a well-known risk factor for breast cancer. This study aimed to search for a possible birth cohort effect on mammographic density, which might contribute to explain the increasing breast cancer incidence. We separately analysed left and right breast density of Dutch women from a 13-year period (2003-2016) in the breast cancer screening programme. Read More

Eur Radiol 2019 Feb 14. Epub 2019 Feb 14.

The Cancer Registry of Norway, P.O. Box 5313, Majorstuen, 0304, Oslo, Norway.

Objectives: To explore performance measures among non-immigrants and immigrants attending BreastScreen Norway.

Methods: We analysed data from 2,951,375 screening examinations among non-immigrants and 153,026 among immigrants from 1996 to 2015. Immigrants were categorised into high- and low-incidence countries according to the incidence of breast cancer in their birth country. Read More

Mod Pathol 2019 Feb 13. Epub 2019 Feb 13.

Department of Anatomic Pathology, Sunnybrook Health Sciences Centre, University of Toronto Faculty of Medicine, E432-2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.

Ductal carcinoma in situ (DCIS) is a neoplastic proliferation of mammary ductal epithelial cells confined to the ductal-lobular system, and a non-obligate precursor of invasive disease. While there has been a significant increase in the diagnosis of DCIS in recent years due to uptake of mammography screening, there has been little change in the rate of invasive recurrence, indicating that a large proportion of patients diagnosed with DCIS will never develop invasive disease. The main issue for clinicians is how to reliably predict the prognosis of DCIS in order to individualize patient treatment, especially as treatment ranges from surveillance only, breast-conserving surgery only, to breast-conserving surgery plus radiotherapy and/or hormonal therapy, and mastectomy with or without radiotherapy. Read More

BMC Public Health 2019 Feb 13;19(1):189. Epub 2019 Feb 13.

Highland Campus, Centre for Health Science, Old Perth Road, Inverness, IV2 3JH, UK.

Background: A range of barriers influence women's uptake to a first breast screening invitation. Few studies however, have examined factors associated with second screening uptake. This study follows Maltese women to explore predictors and behaviours to re-attendance, and to determine if uptake of first invitation to the Maltese Breast Screening Programme (MBSP) is a significant predictor of second screening uptake. Read More

Mymensingh Med J 2019 Jan;28(1):96-104

Professor Shirin Akter Begum, Professor, Department of Gynaecological Oncology, Bangabandhu Sheikh Mujib Medical University, (BSMMU), Dhaka, Bangladesh; E-mail:

In Bangladesh incidence rate of breast cancer was about 22.5 per 100000 females. Breast cancer has been reported as the highest prevalence rate (19. Read More

Cancer 2019 Feb 12. Epub 2019 Feb 12.

Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.

Cancer 2019 Feb 12. Epub 2019 Feb 12.

National Taiwan University, Taipei, Taiwan.

Radiology 2019 Feb 12:181113. Epub 2019 Feb 12.

From the Department of Radiology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637.

Background Previous studies have suggested that breast parenchymal texture features may reflect the biologic risk factors associated with breast cancer development. Therefore, combining the characteristics of normal parenchyma from the contralateral breast with radiomic features of breast tumors may improve the accuracy of digital mammography in the diagnosis of breast cancer. Purpose To determine whether the addition of radiomic analysis of contralateral breast parenchyma to the characterization of breast lesions with digital mammography improves lesion classification over that with radiomic tumor features alone. Read More

Acta Oncol 2019 Feb 12:1-6. Epub 2019 Feb 12.

b Duke University Medical Center, Duke University , Durham , NC, USA.

Background: Persistent breast pain (PBP) is prevalent among breast cancer survivors and has powerful negative psychological consequences. The present study provided a first test of the hypothesis that: (a) pain catastrophizing, (b) heightened perceived risk of cancer, and (c) worry that pain indicates cancer may be independent mediating links between breast cancer survivors' experiences of PBP and heightened emotional distress.

Methodology: We assessed levels of PBP and psychological factors in breast cancer survivors (Survivor Group: n = 417; Stages I-IIIA; White = 88. Read More

J Med Imaging (Bellingham) 2019 Jul 5;6(3):031406. Epub 2019 Feb 5.

Siemens Healthcare GmbH, Forchheim, Germany.

Assessment of breast density at the point of mammographic examination could lead to optimized breast cancer screening pathways. The onsite breast density information may offer guidance of when to recommend supplemental imaging for women in a screening program. A software application (Insight BD, Siemens Healthcare GmbH) for fast onsite quantification of volumetric breast density is evaluated. Read More

J Cytol 2019 Jan-Mar;36(1):53-58

Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.

Aim: The objective of this study was to apply a scoring method to fine needle aspiration cytology on breast duct dilatation and cystic lesions, to set an optimum cut-off value to differentiate between benign and malignant cases, and to identify features useful for cell judgment.

Materials And Methods: Samples were 23 preparations of specimens (12 benign and 11 malignant cases) suspected with intraductal lesions or cystic change by ultrasonography or mammography and cytology. The scoring system comprised the following 10 items, and each item was scored 1-3, with a total score of 10-30. Read More

AJR Am J Roentgenol 2019 Feb 11:1-8. Epub 2019 Feb 11.

1 Department of Radiology, NYU School of Medicine, NYU Langone Health, 160 E 34th St, 3rd Fl, New York, NY 10016.

Objective: The purpose of this study was to assess the rate, type, and severity of complications related to 9-gauge stereotactic vacuum-assisted breast biopsy (SVAB) and to delineate associated factors that may contribute to a higher rate of complications.

Materials And Methods: This retrospective study included 4776 patients who underwent SVAB between 2003 and 2016. A total of 319 patients with documented postbiopsy complications were identified. Read More

Cancer 2019 Feb 11. Epub 2019 Feb 11.

Department of Radiology and Rogel Cancer Center, University of Michigan Health System, Ann Arbor, Michigan.

Background: From 1975 to 1990, female breast cancer mortality rates in the United States increased by 0.4% per year. Since 1990, breast cancer mortality rates have fallen between 1. Read More

J Nepal Health Res Counc 2019 Jan 28;16(41):396-400. Epub 2019 Jan 28.

Department of Radiology and Imaging, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Background: With a palpable lesion in the breast, the goal is to diagnose malignancy at the earliest. Ultrasonography is used for evaluating symptomatic patients especially those with dense breasts where mammography gives limited information. The objective of this study was to evaluate the sonographic pattern of the palpable breast lumps and correlate with the final pathological diagnosis. Read More

Am J Surg 2019 Feb 2. Epub 2019 Feb 2.

Department of Surgery, Mercy Hospital, 4401 W. McAuley Blvd., Suite #1100, Mercy Hospital Coletta Building, Oklahoma City, OK, USA. Electronic address:

From its inception, screening mammography has enjoyed a perceived level of sensitivity that is inconsistent with available evidence. The original data that imparted erroneous beliefs about sensitivity were based on a variety of misleading definitions and approaches, such as the inclusion of palpable tumors, using the inverse of interval cancer rates (often tied to an arbitrary 12 month interval), and quoting prevalence screen sensitivity wherein tumors are larger than those found on incidence screens. This review addresses the background for the overestimation of mammographic sensitivity, and how a major adjustment in our thinking is overdue now that multi-modality imaging allows us to determine real time mammographic sensitivity. Read More

Phys Med 2019 Jan 18;57:25-32. Epub 2018 Dec 18.

National Coordinating Centre for the Physics of Mammography, Royal Surrey County Hospital, Guildford, Surrey, UK; Department of Physics, University of Surrey, Guildford, UK.

Digital breast tomosynthesis (DBT) is currently under consideration for replacement of, or combined use with 2D-mammography in national breast screening programmes. To investigate the potential benefits that DBT can bring to screening, the threshold detectable lesion diameters were measured for different forms of DBT in comparison to 2D-mammography. The aim of this study was to compare the threshold detectable mass diameters obtained with narrow angle (15°/15 projections) and wide angle (50°/25 projections) DBT in comparison to 2D-mammography. Read More

Phys Med 2019 Jan 9;57:137-144. Epub 2019 Jan 9.

Institut de Radioprotection et de Sûreté Nucléaire, PRP-HOM/SER/Unité d'Expertise en Radioprotection médicale, 31 avenue de la Division Leclerc, BP17, 92262 Fontenay-aux-Roses Cedex, France.

Purposes: The introduction of digital breast tomosynthesis (DBT) into the French breast cancer screening program is forecast by the authorities. The aim of the present study was to evaluate image quality phantoms to be used as internal quality controls.

Methods: Seven breast phantoms dedicated to quality control in mammography were evaluated on reconstructed DBT images: ACR Model 015, BR3D, DBT QC model 021, Mam/Digi-EPQC, MTM100, TOMOMAM® and TOMOPHAN®. Read More

Eur Radiol 2019 Feb 8. Epub 2019 Feb 8.

Radiology Unit, AUSL Reggio Emilia, IRCCS, Reggio Emilia, Italy.

Objectives: Tomosynthesis (DBT) has proven to be more sensitive than digital mammography, but it requires longer reading time. We retrospectively compared accuracy and reading times of a simplified protocol with 1-cm-thick slabs versus a standard protocol of slabs + 1-mm-spaced planes, both integrated with synthetic 2D.

Methods: We randomly selected 894 DBTs (including 12 cancers) from the experimental arm of the RETomo trial. Read More

Histopathology 2019 Feb 7. Epub 2019 Feb 7.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Diagnostics Tower, Singapore, 169856.

Aims: Ductal carcinoma in situ (DCIS) of the breast is a heterogeneous disease that has risen to prominence and more recently controversy, with the advent of screening mammography. Debate about the true biological potential of low nuclear grade DCIS continues to challenge therapeutic considerations. In this study, we carried out a comprehensive literature review of the behaviour, outcomes and current management trials of low-grade DCIS, as well as a retrospective study of a large single institutional series of low-grade DCIS diagnosed at our hospital. Read More

Clin Breast Cancer 2018 Dec 7. Epub 2018 Dec 7.

UOC Radiologia, UOS di Senologia Interventistica, Policlinico Tor Vergata: Fondazione PTV, Università di Roma "Tor Vergata", Roma, Italy.

Background: The study aimed to evaluate the feasibility and reliability of ultrasound-guided vacuum-assisted breast biopsy (US-VABB) for sampling of microcalcifications indicative of cancer when stereotactic vacuum-assisted breast biopsy cannot be performed because of reasons such as thin breast tissue, insufficient thickness at compression, and microcalcification situated close to the chest wall or in breast tissue of the axillary tail.

Patients And Methods: The study population was selected from among 187 patients with microcalcifications detected on mammogram. The findings were classified using the American College of Radiology criteria as Breast Imaging Reporting and Data System 3, 4, or 5. Read More

MDM Policy Pract 2019 Jan-Jun;4(1):2381468318812889. Epub 2019 Jan 17.

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Guidelines recommend that initiation of breast cancer screening (BCS) among women aged 40 to 49 years include a shared decision-making process. The objective of this study is to evaluate the effect of a breast cancer screening patient decision-aid (BCS-PtDA) on the strength of the relationship between individual risk and the decision to initiate BCS, knowledge, and decisional conflict. We conducted a randomized clinical trial of a BCS-PtDA that included individual risk estimates compared with usual care. Read More

Breast Cancer Res Treat 2019 Feb 6. Epub 2019 Feb 6.

Center of Familial Breast and Ovarian Cancer, University Hospital Cologne, Cologne, Germany.

Purpose: To report on 10 years of high-risk service screening with annual MRI in the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC).

Methods: A cohort of 4,573 high-risk, previously unaffected women (954 BRCA1 carriers, 598 BRCA2 carriers, 3021 BRCA1/2 non-carriers) participating in the GC-HBOC surveillance program was prospectively followed. Screening outcomes for 14,142 screening rounds with MRI between 2006 and 2015 were analyzed and stratified by risk group, type of screening round, and age. Read More

J Cancer 2019 1;10(3):765-771. Epub 2019 Jan 1.

Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, Maastricht, the Netherlands.

To investigate whether full-field digital mammography (FFDM) and contrast-enhanced mammography (CEM), evaluated by non-experienced high school students, improves detection of missed breast cancer lesions on FFDM, in the same cohort of patients. Non-experienced first- and second year high school students examined fourteen cases of patients diagnosed with breast cancer. These cases consisted of missed breast cancer lesions on FFDM by a breast radiologist. Read More

J Am Coll Radiol 2019 Feb;16(2):135-136

Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, California; General Internal Medicine Section, Department of Veterans Affairs, University of California, San Francisco, California.

Eur Radiol 2019 Feb 4. Epub 2019 Feb 4.

Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, Cambridge University Hospitals NHS Trust, Cambridge, UK.

Objective: To develop methods to model the relationship between cancer detection and recall rates to inform professional standards.

Methods: Annual screening programme information for each of the 80 English NHSBSP units (totalling 11.3 million screening tests) for the seven screening years from 1 April 2009 to 31 March 2016 and some Dutch screening programme information were used to produce linear and non-linear models. Read More

JAMA Intern Med 2019 Feb 4. Epub 2019 Feb 4.

Department of Radiology, Institut de Cancérologie de Lorraine Alexis Vautrin, Vandœuvre-lès-Nancy, France.

Importance: Many women dread undergoing mammography, and some may not attend or reattend breast cancer screening because of the discomfort or pain induced by breast compression.

Objective: To evaluate the noninferiority of the self-compression mammography technique for reducing breast thickness compared with standard compression.

Design, Setting, And Participants: This prospective, parallel-group, noninferiority randomized clinical trial was conducted from May 7, 2013, to October 26, 2015, at 6 cancer care centers in France. Read More

Clin Hemorheol Microcirc 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology and Interdisciplinary Ultrasound Centre and Ultrasound Research Laboratory, University Berlin, Charité, Berlin, Germany.

Background: Besides mammography, breast ultrasound is the most important imaging modality for women with suspected breast cancer. New software tools bear high potential for improved detectability and specification of malignant breast lesions.

Objective: To compare the halo depicted around malignant breast lesions by ultrasound using Acoustic Structure Quantification (ASQ) of raw image data with the echogenic rim seen in B-mode ultrasound. Read More

Women Health 2019 Feb 4:1-16. Epub 2019 Feb 4.

a Department of Marketing and International Management , Alpen-Adria-Universität Klagenfurt , Klagenfurt , Austria.

We explored the use of different advertising appeals in breast cancer detection messages. We analyzed the extent to which emotional appeals were applied in advertisements that promoted two forms of breast cancer detection behaviors: breast self-examination (BSE) and mammographic screening. Findings of a content analysis of 456 breast cancer-related advertisements gathered in February 2016 indicated that textual fear appeals, humor appeals and erotic appeals were more likely to be featured in BSE-promoting advertisements than in breast cancer-related advertisements with other message purposes. Read More

PeerJ 2019 28;7:e6201. Epub 2019 Jan 28.

Electronic & Electrical Engineering Department, University of Strathclyde, Glasgow, United Kingdom.

It is important to detect breast cancer as early as possible. In this manuscript, a new methodology for classifying breast cancer using deep learning and some segmentation techniques are introduced. A new computer aided detection (CAD) system is proposed for classifying benign and malignant mass tumors in breast mammography images. Read More

Ethn Dis 2019 17;29(1):31-38. Epub 2019 Jan 17.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Objectives: Latinas are less likely than non-Latina Whites (NLW) to utilize mammographic screening and are more likely to be diagnosed with late-stage breast cancer. Here, we examine the effects of county-level factors on guideline-concordant breast-cancer screening behaviors in Latinas and NLWs.

Design: Latinas (N=108) and NLW women (N=132) aged >40 years, residing in two adjacent rural, medically underserved counties in eastern Washington State, completed a baseline questionnaire on mammography utilization and demographics. Read More

Value Health 2019 Feb 8;22(2):185-193. Epub 2018 Sep 8.

Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Several specialty societies have recently updated their breast cancer screening guidelines in late 2015/early 2016.

Objectives: To evaluate the cost-effectiveness of US-based mammography screening guidelines.

Methods: We developed a microsimulation model to generate the natural history of invasive breast cancer and capture how screening and treatment modified the natural course of the disease. Read More

Rev Sci Instrum 2019 Jan;90(1):015006

School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, Pennsylvania 19104, USA.

Mammography is the only Food and Drug Administration approved breast cancer screening method. The drawback of the tumor image in a mammogram is the lack of tumor depth information as it is only a 2-dimensional projection of a 3-dimensional (3D) tumor. In this work, we investigated 3D tumor imaging by assessing tumor depth information using a set of piezoelectric fingers (PEFs) with different probe sizes which were known to be capable of eliciting tissue elastic responses to different depths and tested it on model tumor tissues consisted of gelatin with suspended clay inclusions. Read More

Cancer 2019 Feb 1. Epub 2019 Feb 1.

Department of Surgery, Johns Hopkins Hospital and School of Medicine, Baltimore, Maryland.

Background: Screening mammography reduces breast cancer mortality at the cost of frequent false-positive results that lead to unnecessary medical procedures, and the treatment of indolent breast cancers that would never threaten life or health. Earlier diagnosis generally permits less disruptive treatment, but it is possible that even the diagnosis of a very small breast cancer could significantly adversely impact health-related quality of life (HRQOL) in older women.

Methods: The authors compared changes in HRQOL measured by either the Medical Outcomes Study 36-Item Short Form (SF-36) or the Veterans Rand 12-item Health Survey (VR-12) between 198 women diagnosed with in situ or invasive breast cancer measuring ≤1 cm and 36,814 matched controls using the National Cancer Institute's Surveillance, Epidemiology, and End Results cancer registry linked with the Medicare Health Outcomes Survey. Read More

Asia Ocean J Nucl Med Biol 2019 ;7(1):13-21

Department of Nuclear Medicine and Tracer Kinetics, Osaka University, Graduate School of Medicine, Osaka, Japan.

Objectives: To investigate the diagnostic accuracy of positron emission mammography (PEM) and positron emission tomography/computed tomography (PET/CT) for small breast tumors of less than 20 mm in size.

Methods: The study was conducted on a total of 100 subjects (i.e. Read More

Prim Care 2019 Mar 22;46(1):97-115. Epub 2018 Dec 22.

Research Family Medicine Residency, 6675 Holmes Road, Suite 450, Kansas City, MO 64131, USA.

Screening mammography and evolving treatments have improved mortality over the last 25 years. However, breast cancer remains the second leading cause of cancer-related mortality for women in the United States. There are several contradictory recommendations regarding breast cancer screening. Read More

Clin Imaging 2019 Jan 17;55:12-17. Epub 2019 Jan 17.

Department of Radiology, Korea University Guro Hospital, Republic of Korea.

Purpose: Currently in diagnostic setting for breast cancer, FFDM and DBT are performed conjunctively. However, performing two imaging modalities may increase radiation exposure by double. Two-dimensional reconstructed images created from DBT with 2DSM, has a potential to replace conventional FFDM in concerning both radiation dosage and image quality. Read More

BMC Med 2019 Jan 31;17(1):24. Epub 2019 Jan 31.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12 A, 171 77, Stockholm, Sweden.

Background: Breast cancer patients who have not previously attended mammography screening may be more likely to discontinue adjuvant hormone therapy and therefore have a worse disease prognosis.

Methods: We conducted a population-based cohort study using data from Stockholm Mammography Screening Program, Stockholm-Gotland Breast Cancer Register, Swedish Prescribed Drug Register, and Swedish Cause of Death Register. Women in Stockholm who were diagnosed with breast cancer between 2001 and 2008 were followed until December 31, 2015. Read More

Cancer Res Treat 2019 Jan 29. Epub 2019 Jan 29.

National Cancer Control Institute, National Cancer Center, Goyang, Korea.

Purpose: Women with dense breast are known to be at high risk for breast cancer, but their prevalence and number of Korean women are unknown. The current study was to investigate the distribution of mammographic breast density by age of women undergoing screening mammography, and to estimate the prevalence of Korean women with dense breasts, quantitatively.

Materials And Methods: For obtaining a nationwide representative sample, 6,481 mammograms were collected from 86 screening units participated in the National Cancer Screening Program for breast cancer. Read More

Med Phys 2019 Jan 29. Epub 2019 Jan 29.

University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.

Purpose: Women with radiographically dense or texturally complex breasts are at increased risk for interval cancer, defined as cancers diagnosed after a normal screening examination. The purpose of this study was to create masking measures and apply them to identify interval risk in a population of women who experienced either screen-detected or interval cancers after controlling for breast density.

Methods: We examined full-field digital screening mammograms acquired from 2006 to 2015. Read More