Search Our Scientific Publications & Authors

Tohoku J Exp Med 2019 ;247(2):99-110

Division of Community Health, Tohoku University Graduate School of Medicine.

Although cigarette smoking is a major risk factor for lung cancer, genetic susceptibility may also affect lung cancer risk. To explore the role of genetic risk, this case-control study investigated the association between family history of cancer at several sites and lung cancer risk. A total of 1,733 lung cancer cases and 6,643 controls were selected from patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009. Read More

Expert Rev Endocrinol Metab 2011 Sep;6(5):723-730

a Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.

Gynecomastia is a benign proliferation of glandular tissue of the breast in males. It is common during three phases in the age distribution curve: the neonatal period, puberty and senescence. An imbalance between estrogen and androgen action at the level of breast tissue is believed to be the underlying pathophysiology. Read More

Clin Transl Oncol 2019 Feb 16. Epub 2019 Feb 16.

Breast Cancer Surgery Department, Instituto Nacional de Enfermedades Neoplasicas, Av. Angamos Este 2520 Surquillo, 15038, Lima, Peru.

Purpose: This study aims to evaluate the association between composition of tumor-infiltrating lymphocytes (TIL) and expression of p16 in acral lentiginous melanoma (ALM), and their impact on prognosis.

Materials And Methods: A cohort of 148 surgical pathology specimens of ALM was studied. TIL were evaluated by immunohistochemical detection of CD3 and CD8, along with CD20, CD4, CD68, and CD163 in a subset of 43 cases. Read More

Front Oncol 2019 4;9:24. Epub 2019 Feb 4.

Department of Breast Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Hexavalent chromium [Cr(VI)] is an occupational carcinogen that can cause lung and nasal cancers, but its association with mortality and incidence in many other cancers is unclear. In this meta-analysis, we aimed to evaluate the relationship between exposure to Cr(VI) and the mortality and incidence of human cancers. We performed a search of the literature and extracted the standardized mortality ratios (SMRs), standardized incidence ratios (SIRs), and their corresponding 95% confidence intervals (CIs), to estimate risk values. Read More

Br J Cancer 2019 Feb 19. Epub 2019 Feb 19.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.

Background: The present study examined whether adult height was associated with all site-combined or site-specific cancers.

Methods: We used a nationwide claim data of 22,809,722 Korean participants including both men and women (2009-2012). The deciles of height from different age and sex groups were merged into a new quintile. Read More

Int J Equity Health 2019 Feb 18;18(1):35. Epub 2019 Feb 18.

School of Social Professions, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK.

Background: Hormonal therapy is an integral component for breast cancer treatment in women with oestrogen receptor positive tumours in early-stage and advanced cases of the disease. Little is known about what factors influence oncologists' prescribing practices, especially non-biological factors, although this information may have important implications for understanding inequalities in health care quality and outcomes. This paper presents findings from research on factors influencing oncologists' prescribing hormonal therapy for women with early and advanced cases of breast cancer in the city of Córdoba, Argentina. Read More

J Geriatr Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmaceutical Systems and Policy, West Virginia University, School of Pharmacy, PO Box 9510, Morgantown, West, Virginia 26505, USA. Electronic address:

Objectives: To assess the association between Potentially Inappropriate Medication (PIM) use and healthcare utilization and costs among Medicare beneficiaries with breast, prostate, or colorectal cancer.

Materials And Methods: A retrospective cohort study was conducted using the SEER-Medicare linked database in older adults with breast (N = 17,630), prostate (N = N = 18,721), or colorectal cancer (female: N = 5652; male: N = 3768). PIM use was defined based on 2015 Beers Criteria and was measured using prescription claims. Read More

Anticancer Agents Med Chem 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Dunav -2 Street, 1000 Sofia. Bulgaria.

Background: The accidental discovery of cisplatin's growth-inhibiting properties a few decades ago led to resurgence of interest in metal-based chemotherapeutics. A number of well-discussed factors such as severe systemic toxicity and unfavourable physicochemical properties further limit the clinical application of the platinating agents. Great efforts have been placed in the development of alternative platinum derivatives with an extended antitumor spectrum and amended toxicity profile as compared to the reference drug cisplatin. Read More

Fed Pract 2018 Feb;35(Suppl 1):S20-S21

is a Past President, AVAHO (2016), Hematologist/Oncologist at Washington DC VAMC and Associate Professor of Hematology/Oncology at Georgetown University School of Medicine in Washington DC. is a male breast cancer advocate and is pursuing a MS in psychology.

Ann Surg Oncol 2019 Feb 13. Epub 2019 Feb 13.

Department of Surgery, University of California, Davis Medical Center, Sacramento, CA, USA.

Background: Current treatment guidelines for male breast cancer are predominantly guided by female-only clinical trials. With scarce research, it is unclear whether breast-conserving therapy (BCT) is equivalent to mastectomy in men. We sought to compare overall survival (OS) among male breast cancer patients who underwent BCT versus mastectomy. Read More

BMC Cancer 2019 Feb 13;19(1):145. Epub 2019 Feb 13.

Department of Surgical Oncology, First Hospital of China Medical University, Shenyang, 110001, Liaoning Province, China.

Background: The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases.

Methods: Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017. Read More

Mymensingh Med J 2019 Jan;28(1):254-258

Dr Sabrina Yesmin, Associate Professor and Head, Department of Medicine, Dr Sirajul Islam Medical College Hospital, Dhaka, Bangladesh; E-mail:

Breast cancer in male is rare which accounts about 1% of all malignant breast neoplasm cases. Since paraneoplastic syndrome is unusual with male breast cancer, very few reported cases are found. A72- year-old gentleman presented with proximal myopathy in all four limbs was referred to Dr. Read More

BMC Public Health 2019 Feb 12;19(1):180. Epub 2019 Feb 12.

Department of Pathology, Faculty of Health Sciences - East Africa, Aga, Khan University Nairobi, 3rd Parklands Avenue, P.O. Box 30270-00100, Nairobi, Kenya.

Background: Data on breast healthcare knowledge, perceptions and practice among women in rural Kenya is limited. Furthermore, the role of the male head of household in influencing a woman's breast health seeking behavior is also not known. The aim of this study was to assess the knowledge, perceptions and practice of breast cancer among women, male heads of households, opinion leaders and healthcare providers within a rural community in Kenya. Read More

Kidney Cancer 2018 Aug 1;2(2):123-131. Epub 2018 Aug 1.

NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW, Australia.

Background: Decisions about adjuvant therapy involve trade-offs between possible benefits and harms.

Objective: We sought to determine the survival benefits that clinical investigators would judge as sufficient to warrant treatment with adjuvant sorafenib in the SORCE trial after nephrectomy for apparently localised renal cell carcinoma (RCC).

Methods: A subset of clinical investigators in the SORCE trial completed a validated questionnaire that elicited the minimum survival benefits they judged sufficient to warrant one year of adjuvant sorafenib in scenarios with hypothetical baseline survival times of 5 years and 15 years, and baseline survival rates at 5 years of 65% and 85%. Read More

Cancer Med 2019 Feb 7. Epub 2019 Feb 7.

Center for Clinical Genetics and Genomics, Providence St. Joseph Health, Los Angeles, California.

Background: Despite a growing body of literature describing the geographic and sociodemographic distribution of cancer genetic testing, work focused on these domains in cancer genetic counseling is limited. Research describing the epidemiology of cancer genetic counseling has mainly focused on isolated populations, a single gender (women) and a single condition (hereditary breast and ovarian cancer). Study findings to date are contradictory, making it unclear what, if any, disparities in receipt of cancer genetic counseling exist. Read More

Dis Markers 2019 10;2019:4081962. Epub 2019 Jan 10.

Key Laboratory of Molecular Biology for Sinomedicine, Yunnan University of Traditional Chinese Medicine, Kunming 650500, China.

The main aim of the present study was to investigate the biological function of uric acid. The level of uric acid in different organs in normal male rats was determined with uric acid assay kits, and the expression level of genes in the organs was determined by RNA quantitative sequencing. The correlation analysis between uric acid in the organs and gene expression (measured by FPKM value) was made. Read More

Radiat Res 2019 Feb 7. Epub 2019 Feb 7.

Department of a   Oncology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

To elucidate the potential influence of stimulating bone marrow before cell-cycle-dependent irradiation, we sought to determine overall survival in mice receiving total-body irradiation (TBI) when administered granulocyte stimulating factor (G-CSF) at different time points. Gender differences were also studied. C57/BL/6J mice, aged 9-14 weeks, received 8 Gy TBI in a perspex cage using a linear accelerator. Read More

J Cancer 2019 1;10(3):583-593. Epub 2019 Jan 1.

Department of Anesthesiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, People's Republic of China.

Male breast cancer (MBC) is a rare tumor with few cases for research. Using the Surveillance, Epidemiology, and End Results program database, we carried out a competing risk analysis in patients with primary nonmetastatic MBC and built a predictive nomogram. We extracted primary nonmetastatic MBC patients according to the inclusion and exclusion criteria. Read More

Pathol Oncol Res 2019 Feb 4. Epub 2019 Feb 4.

Laboratory of Biomedical Genomics and Oncogenetics (LRTI, IPT 05), Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.

Breast cancer is currently the leading cause of cancer morbidity and mortality among Algerian women. In this study, we aimed to investigate the mutation spectrum of BRCA1 and BRCA2 genes in hereditary breast/ovarian cancer (HBOC) families from the Aures region (eastern Algeria). High risk breast/ovarian cancer families were selected from overall 1162 consecutive patients collected from cancer registry of anticancer center of Batna. Read More

Indian J Nucl Med 2019 Jan-Mar;34(1):10-13

Department of Nuclear Medicine, Basavatarakam Indo-American Cancer Hospital and Research Institute, Hyderabad, Telangana, India.

Objectives: The objective of this study was to correlate maximum standardized uptake value (SUV) with different immunohistochemical subtypes of breast cancer and other prognostic factors in breast cancer.

Subjects And Methods: This was a retrospective study including 219 consecutive patients undergoing whole-body fluorodeoxyglucose positron emission tomography/computed tomography scan for the staging of breast cancer. Out of 219 patients, two were male and 217 were female; age ranged from 26 to 85 years with mean age of 54 years. Read More

JAMA Netw Open 2019 Feb 1;2(2):e187633. Epub 2019 Feb 1.

Center for Surgery and Public Health, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Importance: It is not known whether racial/ethnic differences in receipt of palliative care are attributable to different treatment of minorities or lower utilization of palliative care at the relatively small number of hospitals that treat a large portion of minority patients.

Objective: To assess the association of receipt of palliative care among patients with metastatic cancer with receipt of treatment at minority-serving hospitals (MSHs) vs non-MSHs.

Design, Setting, And Participants: This retrospective cohort study used Participant Use Files of the National Cancer Database, a prospectively maintained, hospital-based cancer registry consisting of all patients treated at more than 1500 US hospitals, to collect data from individuals older than 40 years with metastatic prostate, lung, colon, and breast cancer, diagnosed from January 1, 2004, to December 31, 2015. Read More

Radiol Case Rep 2019 Apr 16;14(4):427-429. Epub 2019 Jan 16.

General Radiologist at CediMed and Hospital Pablo Tobón Uribe, Radiology Professor at Universidad CES and Universidad Pontificia Bolivariana, Medellín, Colombia.

Breast hemangioma is a rare benign tumor in female and extremely rare in males. They are part of vascular tumors. Here, we described the case of a male patient who had a breast hemangioma for 30 years that was diagnosed incidentally in a thorax and abdomen tomography. Read More

Iran J Pathol 2018 17;13(2):167-172. Epub 2018 Jul 17.

Dept. of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background & Objective: mutations are reported in many types of cancers including pancreas, lung, colon, breast,and gastric (GC). High frequency of mutation is observed in the pancreas,colon, and lung cancers; they commonly arise in codon 12 and 13 of exon 2. Due to the lack of information about the frequency of mutations in the Northeast of Iran, the currentstudy aimed at evaluating frequency in cases with GC in this region. Read More

Case Rep Endocrinol 2018 31;2018:3652602. Epub 2018 Dec 31.

Department of Endocrinology, West Virginia University, Morgantown, WV, USA.

Context: To describe a case of invasive ductal carcinoma of the breast in a transgender male receiving testosterone therapy for gender-affirming treatment.

Case Description: A 28-year-old transgender male receiving intramuscular testosterone was found to have a breast mass on ultrasound after self-exam revealed a palpable breast lump. Ultrasound-guided breast biopsy revealed estrogen receptor/progesterone receptor (ER/PR) negative, human epidermal growth factor receptor-2 (HER-2) positive, invasive ductal carcinoma of the left breast. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1857-1859

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

History of male breast cancer and pancreatic cancer are important for diagnosis of hereditary breast and ovarian cancer syndrome(HBOC), while advanced pancreatic cancer is reported to have metastasis to mammary gland tissue. A 67-year-old man visited a local hospital because fever and right hypochondrial pain. Computed tomography scan revealed pancreatic cancer with multiple liver metastasis and peritoneal metastasis. Read More

Front Oncol 2018 9;8:647. Epub 2019 Jan 9.

Department of Surgery, University of Maryland School of Medicine Baltimore, Baltimore, MD, United States.

Despite limited oncologic benefit, contralateral prophylactic mastectomy (CPM) rates have increased in the United States over the past 15 years. CPM is often accompanied by breast reconstruction, thereby requiring an interdisciplinary approach between breast and plastic surgeons. Despite this, little is known about plastic surgeons' (PS) perspectives of CPM. Read More

Nat Commun 2019 01 25;10(1):431. Epub 2019 Jan 25.

Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA, 98109-1024, USA.

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r = 0. Read More

BMC Biol 2019 Jan 25;17(1). Epub 2019 Jan 25.

Department of Biology, College of Art and Sciences, Syracuse University, Syracuse, NY, 13244, USA.

Background: Sex determination mechanisms in teleost fish broadly differ from mammals and birds, with sex chromosomes that are far less differentiated and recombination often occurring along the length of the X and Y chromosomes, posing major challenges for the identification of specific sex determination genes. Here, we take an innovative approach of comparative genome analysis of the genomic sequences of the X chromosome and newly sequenced Y chromosome in the channel catfish.

Results: Using a YY channel catfish as the sequencing template, we generated, assembled, and annotated the Y genome sequence of channel catfish. Read More

J Genet Couns 2019 Jan 24. Epub 2019 Jan 24.

Center for Cancer Genetics and Prevention, Dana-Farber Cancer Institute, Boston, Massachusetts.

Transgender individuals comprise a growing patient population in genetic counseling practice. The identification of a pathogenic variant in a cancer susceptibility gene may impact a transgender person's decisions regarding hormonal and/or surgical transition. Limited scientific literature exists on specific genetic counseling needs and medical management strategies for transgender individuals. Read More

Int J Clin Pharm 2019 Jan 25. Epub 2019 Jan 25.

Department of Pharmacy, Xiamen Maternity and Child Health Care Hospital, No. 10 Zhenhai Road, Xiamen, 361001, Fujian Province, China.

Background Tamoxifen is an estrogen receptor modulator used for the treatment of breast cancer; however, currently, it is used in many off-label indications. Objective To investigate the prevalence of tamoxifen off-label prescribing and explore available scientific evidence that supports those uses in outpatients. Setting Xiamen maternity and child health care hospital in Xiamen city of China. Read More

Nat Commun 2019 01 24;10(1):416. Epub 2019 Jan 24.

Epigenetics Laboratory, Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, 2010, NSW, Australia.

DNA replication timing is known to facilitate the establishment of the epigenome, however, the intimate connection between replication timing and changes to the genome and epigenome in cancer remain largely uncharacterised. Here, we perform Repli-Seq and integrated epigenome analyses and demonstrate that genomic regions that undergo long-range epigenetic deregulation in prostate cancer also show concordant differences in replication timing. A subset of altered replication timing domains are conserved across cancers from different tissue origins. Read More

Asian Pac J Cancer Prev 2019 Jan 25;20(1):243-248. Epub 2019 Jan 25.

Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Email:

Background: Pathology and laboratory medicine (PALM) services are limited in low-resource countries, such as Lao PDR. Patients with malignant pleural effusion (MPE) are not properly diagnosed and treated in these situations. The purpose of this study is to confirm the usefulness of immunocytochemistry in MPE to identify the histological type and probable primary site of cancer of MPE and to discuss its usefulness in low-resource countries, such as Laos. Read More

Zhonghua Zhong Liu Za Zhi 2019 Jan;41(1):19-28

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Data from local cancer registries were pooled to estimate cancer incidence and mortality in China, 2015. Data submitted from 501 cancer registries were checked & evaluated according to the criteria of data quality control, and 368 registries' data were qualified for the final analysis. Data were stratified by area (urban/rural), sex, age group and cancer sites, and combined with national population data to estimate cancer incidence and mortality in China, 2015. Read More

Cureus 2018 Nov 14;10(11):e3589. Epub 2018 Nov 14.

Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, CAN.

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor arising predominantly on sun-exposed skin among the elderly. The most common location is the head and neck, followed by the extremities. MCCs are highly aggressive tumors and rarely undergo spontaneous regression. Read More

Can Fam Physician 2019 Jan;65(1):e30-e37

Scientist at the Centre for Urban Health Solutions in the Li Ka Shing Knowledge Institute at St Michael's Hospital, a staff physician in the Department of Family and Community Medicine at St Michael's Hospital, Assistant Professor and Clinician Scientist in the Department of Family and Community Medicine at the University of Toronto, Adjunct Scientist at ICES, and Assistant Professor in the Dalla Lana School of Public Health.

Objective: To compare rates of cervical, breast, and colorectal cancer screening between patients who are transgender and those who are cisgender (ie, nontransgender).

Design: Cross-sectional study.

Setting: A multisite academic family health team in Toronto, Ont, serving more than 45 000 enrolled patients. Read More

J Clin Nurs 2019 Jan 22. Epub 2019 Jan 22.

Department of Psychology, University of Malta, Msida, Malta.

Aims And Objectives: To investigate the experiences of male partners of female breast cancer patients who had undergone surgery and oncological treatment and who were still raising children.

Background: Research on the psychological effects of breast cancer has focused primarily on the patients undergoing treatment, neglecting the effect of such a condition on their closest family members. This study addresses this gap by focusing on understanding the effects of this disease on male partners of these patients. Read More

Breast Cancer Res Treat 2019 Jan 21. Epub 2019 Jan 21.

Division of Surgical Oncology, Massachusetts General Hospital, Boston, MA, USA.

Purpose: Atypical ductal hyperplasia (ADH) significantly increases the risk of breast cancer in women. However, little is known about the implications of ADH in men.

Methods: Review of 932 males with breast pathology was performed to identify cases of ADH. Read More

Br J Cancer 2019 Feb 17;120(3):301-305. Epub 2019 Jan 17.

Department of Obstetrics and Gynaecology, Otto-von-Guericke University, Magdeburg, Germany.

Purpose: Thromboembolism is a common adverse event in women treated with tamoxifen (TAM) for breast cancer. The risk in male breast cancer patients is poorly investigated. We aimed to examine the risk of thrombotic events after TAM in male breast cancer patients. Read More

Clin Breast Cancer 2018 Dec 20. Epub 2018 Dec 20.

Department of Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy. Electronic address:

Am J Ind Med 2019 Mar 15;62(3):205-211. Epub 2019 Jan 15.

Occupational Cancer Research Centre, Cancer Care Ontario, Ontario, Canada.

Background: The recently established Occupational Disease Surveillance System (ODSS) was used to examine breast cancer risk in women and men by occupation and industry.

Methods: Ontario workers in the ODSS cohort (1983-2016) were followed up for breast cancer diagnosis through the Ontario Cancer Registry. Cox-proportional hazard models were used to calculate age-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Read More

Clin Cancer Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Internal Medicine, Medical University of Vienna

Background: Brain metastases (BM) are a rare but devastating condition in estrogen receptor (ER)- positive metastatic breast cancer (MBC). While endocrine therapy (ET) is the mainstay of treatment in this disease subtype, only case reports have been published concerning the activity of ET in BM henceforth. Therefore, we aimed to systematically investigate the impact of ET after diagnosis of BM on outcome and clinical course of disease in patients with ERpositive MBC. Read More

Sensors (Basel) 2019 Jan 10;19(2). Epub 2019 Jan 10.

Department of Radiology, Mayo Clinic College of Medicine & Science, Rochester, MN 55905, USA.

Vascular networks can provide invaluable information about tumor angiogenesis. Ultrafast Doppler imaging enables ultrasound to image microvessels by applying tissue clutter filtering methods on the spatio-temporal data obtained from plane-wave imaging. However, the resultant vessel images suffer from background noise that degrades image quality and restricts vessel visibilities. Read More

Medicine (Baltimore) 2019 Jan;98(2):e14045

Institute of Digestive Surgery and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Tenascin-C (TNC), an extracellular matrix glycoprotein, has been implicated in progression of various types of cancer. However, few reports exist on TNC expression in gastrointestinal stromal tumors (GISTs). We here attempted to investigate the expression pattern and prognostic significance of TNC in gastric GISTs. Read More

Hered Cancer Clin Pract 2019 3;17. Epub 2019 Jan 3.

3Departments of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: As a large-scale study of Koreans, we evaluated the association between BRCA mutation and the prevalence of non-breast and ovary cancers in first- and second-degree relatives of high-risk breast cancer patients.

Methods: We organized familial pedigrees of 2555 patients with breast cancer who underwent genetic screening for in Samsung Medical Center between January 2002 and May 2018. Families with a member that had a history of cancer other than of the breast or ovary were regarded positive for other primary cancer. Read More

J Cell Mol Med 2019 Mar 8;23(3):2263-2267. Epub 2019 Jan 8.

Department of Biochemistry and Pharmacology, University of Medicine and Pharmacy "Victor Babes" Timisoara, Timisoara, Romania.

Soy-based diets have triggered the interest of the research community due to their beneficial effects on a wide variety of pathologies like breast and prostate cancer, diabetes and atherosclerosis. However, the molecular details underlying these effects are far from being completely understood; several recent attempts have been made to elucidate the soy-induced liver transcriptome changes in different animal models. Here we used Next Generation Sequencing to identify a set of microRNAs specifically modulated by short-term soy-enriched diet in young male mice and estimated their impact on the liver transcriptome assessed by microarray. Read More

Int J Colorectal Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Epidemiology and Biostatistics, First Affiliated Hospital, Army Medical University, 30 Gaotanyan Street Shapingba District, Chongqing, 400038, China.

Purpose: To investigate the incidence and the associated factors for bone metastases (BM) development and prognosis in initial colorectal cancer (CRC) with a large sample using Surveillance, Epidemiology, and End Results (SEER) cohort.

Methods: Primary CRC patients, who were initially diagnosed between 2010 and 2015 in the SEER database, were included to analyze BM incidence and risk factors for BM occurrence. The patients with at least 1-year follow-up were involved to investigate the prognostic factors for BM. Read More

BMC Public Health 2019 Jan 7;19(1):22. Epub 2019 Jan 7.

Hebrew University-Hadassah Braun School of Public Health and Community Medicine, Ein Kerem, 91120, Jerusalem, Israel.

Background: Inequalities among the western population, combined with the introduction of new treatment options for cancer, have challenged endeavors to provide equal care to patients with cancer. Israel's highly developed healthcare system and mandatory National Health Insurance afforded an opportunity to study geographic variation over time in mortality following cancer diagnosis.

Methods: This historical prospective cohort study included a nationally representative cohort that was assessed by the Israeli Central Bureau of Statistics 1995 census and followed until 2011. Read More

BMC Cancer 2019 Jan 7;19(1):23. Epub 2019 Jan 7.

ABC Medical School, Epidemiology and Data Analysis Laboratory, Santo Andre, SP, Brazil.

Background: Male Breast Cancer (MBC) is rare, which makes its understanding and treatment be extrapolated from what is known about the occurrence in women, with few epidemiological studies, with few epidemiological studies. Therefore, the aim of the present paper was to study breast cancer mortality in adult males in Brazil and its administrative regions between 2005 and 2015.

Methods: Ecological study with data on MBC mortality in adults between 2005 and 2015. Read More

Int J Cancer 2019 Jan 7. Epub 2019 Jan 7.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Breast cancer (BC) in men is rare and genetic predisposition is likely to play a relevant role in its etiology. Inherited mutations in BRCA1/2 account for about 13% of all cases and additional genes that may contribute to the missing heritability need to be investigated. In our study, a well-characterized series of 523 male BC (MBC) patients from the Italian multicenter study on MBC, enriched for non-BRCA1/2 MBC cases, was screened by a multigene custom panel of 50 cancer-associated genes. Read More

Urol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT. Electronic address:

Introduction: Recent advances in cancer research have highlighted the role of genetics in malignancy. Genetic dysregulation of core cellular functions similarly influences benign conditions. These common genetic factors have led researchers to identify an association between certain urologic conditions and malignancy. Read More