Search Our Scientific Publications & Authors

Phys Med 2021 Jun 12;87:90-98. Epub 2021 Jun 12.

Department of Radiological Sciences (LCR), State University of Rio de Janeiro (UERJ), Pavilhão Haroldo Lisboa da Cunha, Rua São Francisco Xavier, 524, Maracanã, Rio de Janeiro, RJ CEP 20550-900, Brazil.

Purpose: Mammography is the diagnostic imaging practice used in screening to detect early lesions suspected of malignancy. It uses a low energy X-ray beam in which a low dose in the order of 2-3 mGy is delivered to patient breast cells. However, it has been speculated that it could lead to significant cell damage, when compared to conventional X-ray. Read More

Complement Ther Clin Pract 2021 Jun 1;44:101424. Epub 2021 Jun 1.

Department of Physical Education at the Center for Health Sciences and Sports and Professor Postgraduate Program in Human Movement Sciences, Santa Catarina State University, Brazil.

The purpose of the study is to analyze the effects of a mat Pilates intervention on the postural alignment and balance of breast cancer women receiving hormone therapy. A two-arm randomized clinical trial included 34 breast cancer survivors divided randomly between a mat Pilates group (n = 18), that performed 16 weeks of mat Pilates exercises, and a control group (n = 16), who were invited to maintain their daily routine activities and received three educational sessions. Data collection occurred at baseline and at post-intervention time. Read More

Biomed Pharmacother 2021 Jun 11;141:111815. Epub 2021 Jun 11.

Department of Neurobiology and Developmental Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States.

Breast cancer remains one of the leading cancers among women. Cancer stem cells (CSCs) are tumor-initiating cells which drive progression, metastasis, and reoccurrence of the disease. CSCs are resistant to conventional chemo- and radio-therapies and their ability to survive such treatment enables tumor reestablishment. Read More

Bioorg Chem 2021 May 31;114:105041. Epub 2021 May 31.

Biomolecules Discovery Group, Universidad Regional Amazónica Ikiam, Km 7 Via Muyuna, Tena, Napo, Ecuador. Electronic address:

Cationic peptides bio-inspired by natural toxins have been recognized as an efficient strategy for the treatment of different health problems. Due to the specific interaction with substrates from biological membranes, snake venom phospholipases (PLAs) represent valuable scaffolds for the research and development of short peptides targeting parasites, bacteria, and cancer cells. Considering this, we evaluated the in vitro therapeutic potential of three biomimetic peptides (pCergo, pBmTxJ and pBmje) based on three different amino acid sequences from Asp49 PLAs. Read More

Breast 2021 May 27;59:44-50. Epub 2021 May 27.

Department of Breast, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China. Electronic address:

Background: Many breast cancer clinical trials with PARPi have been completed or are currently carried out, either by monotherapy or combined with chemotherapy. We aim to assess the efficacy and safety of PARPi in breast cancer patients as compared to chemotherapy.

Methods: A comprehensive literature search of PubMed, EMBASE, CENTRAL, conference meetings and clinical trial registry was performed. Read More

PLoS Comput Biol 2021 Jun 15;17(6):e1009066. Epub 2021 Jun 15.

Centre for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.

Collective dynamics in multicellular systems such as biological organs and tissues plays a key role in biological development, regeneration, and pathological conditions. Collective tissue dynamics-understood as population behaviour arising from the interplay of the constituting discrete cells-can be studied with on- and off-lattice agent-based models. However, classical on-lattice agent-based models, also known as cellular automata, fail to replicate key aspects of collective migration, which is a central instance of collective behaviour in multicellular systems. Read More

PLoS One 2021 15;16(6):e0253202. Epub 2021 Jun 15.

UItrasonic Diagnosis Department, Chengcheng County Hospital, Weinan, Shanxi province, China.

This paper establishes a fully automatic real-time image segmentation and recognition system for breast ultrasound intervention robots. It adopts the basic architecture of a U-shaped convolutional network (U-Net), analyses the actual application scenarios of semantic segmentation of breast ultrasound images, and adds dropout layers to the U-Net architecture to reduce the redundancy in texture details and prevent overfitting. The main innovation of this paper is proposing an expanded training approach to obtain an expanded of U-Net. Read More

J Clin Oncol 2021 Jun 15:JCO2100112. Epub 2021 Jun 15.

Center for Advancing Population Science, Medical College of Wisconsin, Milwaukee, WI.

Purpose: The objective was to examine the relationship between contemporary redlining (mortgage lending bias on the basis of property location) and survival among older women with breast cancer in the United States.

Methods: A redlining index using Home Mortgage Disclosure Act data (2007-2013) was linked by census tract with a SEER-Medicare cohort of 27,516 women age 66-90 years with an initial diagnosis of stage I-IV breast cancer in 2007-2009 and follow-up through 2015. Cox proportional hazards models were used to examine the relationship between redlining and both all-cause and breast cancer-specific mortality, accounting for covariates. Read More

Cancer Rep (Hoboken) 2021 Jun 15:e1448. Epub 2021 Jun 15.

Faculty of Medicine, University of Misurata, Misrata, Libya.

Background: Cancer incidence and cancer registries are essential for local epidemiological information. In Libya, scarce evidence exists with regard to incidence rates and distribution.

Aim: To estimate cancer incidence in Libya and draw trends of cancer type distribution compared to regional and worldwide data. Read More

Breast Cancer Res Treat 2021 Jun 15. Epub 2021 Jun 15.

Division of Surgical Oncology, Department of Surgery, University of Wisconsin, 600 Highland Ave, Madison, WI, 53792, USA.

Purpose: Controversy remains regarding the optimal margin width for patients with ductal carcinoma in situ (DCIS) who undergo breast conserving surgery (BCS).

Methods: Women with a primary DCIS diagnosis were enrolled in a statewide population-based cohort from 1997 to 2006. Patients were surveyed every two years with follow-up data available through 2016. Read More

Recenti Prog Med 2021 Jun;112(6):465-469

UO Medicina Nucleare, Dipartimento Interdisciplinare di Medicina, Università di Bari "Aldo Moro", Bari.

Purpose: The aim of this study was to assess compliance with guidelines recommendations in the follow-up of patients with breast cancer. In this setting of patients we analyzed the appropriateness of the imaging exams recommended by different specialists in the management of follow-up.

Materials And Methods: From January 2019 to December 2019 we analyzed the clinical data and the results of the imaging exams of 146 asymptomatic patients followed for follow-up in different regional radiotherapy centers. Read More

Recenti Prog Med 2021 Jun;112(6):458-464

Unit of Medical Oncology, Brest Unit located at the Mater Salutis Hospital in Legnago, Italy.

Introduction: The adherence to recognized guidelines and the constant monitoring of performance throughout quality indicators (QIs) are strategic tools to improve the quality of care. The study is aimed to assess the effect of the EUSOMA (European Society of Breast Cancer Specialists) certification process on the quality of breast cancer care of an EUSOMA certified Breast Unit (BU) of Northern Italy.

Materials And Methods: Seventeen mandatory and recommended EUSOMA QIs, based on 594, were analysed for the years 2015-2018. Read More

J Registry Manag 2020 ;47(3):175-177

J Registry Manag 2020 ;47(3):118-121

Objectives: To examine cancer incidence among the 3 Asian, non-Hispanic ethnicities with the highest frequency of cases (South Asian, Chinese, and Vietnamese).

Methods: Age-adjusted incidence rates for all invasive cancers were calculated for South Asian (Indian, Pakistani), Chinese, and Vietnamese cancer cases reported to the Massachusetts Cancer Registry (MCR). Additionally, rates were calculated for the most frequent cancers among non-Hispanic Asians (prostate, colorectal, female breast, female thyroid, lung, and male liver). Read More

J Registry Manag 2020 ;47(3):102-112

Background: Cancer survival statistics can provide a means to assess the effectiveness of the cancer care system, including early detection strategies, the quality of clinical care, and disease management. Disparities in cancer survival (for instance, by neighborhood-level income) persist in Ontario, Canada despite the existence of a universal health care system. Lower income has been associated with an increased incidence of cancer and worsened survival. Read More

Medicine (Baltimore) 2021 Jun;100(24):e26337

Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea.

Abstract: Continuous wound infusion usually provides postoperative analgesia as a multimodal analgesia with systemic opioid use. When continuous wound infusion of local anesthetics (LA) supports successful postoperative analgesia without systemic opioid use, the side effects of opioid can be reduced. Nevertheless, continuous wound infusion after mastectomy with immediate autologous breast reconstruction leads to concerns about wound healing. Read More

Medicine (Baltimore) 2021 Jun;100(24):e26332

Institute of Business, School of Business, Henan University, Jinming Avenue, Kaifeng, Henan, China.

Background: Patients after breast cancer surgery have a high sense of stigma due to the formation of surgical scars, loss of breast shape or other reasons, leading to anxiety, depression, and other adverse mental health problems, thus reducing their quality of life. Remote peer support intervention based on telephone, internet or email is low-cost and easy to spread, and protects patients' privacy, solves the barriers to access that many patients face when attending face-to-face programs. Therefore, remote peer support may be an effective way to reduce stigma and improve mental health in patients after breast cancer surgery during the coronavirus disease 2019 (COVID-19) pandemic. Read More

Medicine (Baltimore) 2021 Jun;100(24):e26175

Department of Breast Surgery, Breast Cancer Institute, The Third Hospital of Nanchang, Nanchang, China.

Abstract: Reconstruction of breast defects of patients who underwent mastectomy can be challenging. This study was designed to review a series of 43 breast cancer patients who underwent immediate breast reconstruction (IBR) using the latissimus dorsi myocutaneous flap with/without implants. The demographic characteristics, clinical application feasibility, and the satisfaction rates of the patients were retrospectively collected and evaluated. Read More

JCI Insight 2021 Jun 15. Epub 2021 Jun 15.

Department of Therapeutic Radiology, Yale School of Medicine, New Haven, United States of America.

The blood-brain barrier (BBB) prevents antibodies from penetrating the CNS and limits conventional antibody-based approaches to brain tumors. We now show that ENT2, a transporter that regulates nucleoside flux at the BBB, may offer an unexpected path to circumventing this barrier to allow targeting of brain tumors with an anti-DNA autoantibody. Deoxymab-1 (DX1) is a DNA-damaging autoantibody that localizes to tumors and is synthetically lethal to cancer cells with defects in the DNA damage response. Read More

Expert Opin Ther Pat 2021 Jun 15. Epub 2021 Jun 15.

Department of Pharmaceutical Chemistry, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India 382481.

Introduction: Wnt signaling is a signal transduction pathway that plays a vital role in embryonic development and normal tissue preservation. Dysfunction of this pathway gives rise to many diseased conditions like cancer, Alzheimer's, metabolic and skeletal disorders, kidney and liver disease, etc. Thus, targeting the Wnt pathway can be a potential approach to design and develop novel therapeutic classes. Read More

Expert Opin Drug Metab Toxicol 2021 Jun 15. Epub 2021 Jun 15.

Department of Genetics and Genomics, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates.

: Paclitaxel is a microtubule stabilizer that is currently one of the most utilized chemotherapeutic agents. Its efficacy in breast, uterine, lung and other neoplasms made its safety profile enhancement a subject of great interest. Neurotoxicity is the most common paclitaxel-associated toxicities. Read More

Expert Opin Drug Saf 2021 Jun 15. Epub 2021 Jun 15.

George Washington University Medical Faculty Associates, 2150 Pennsylvania Ave, NW 7th Floor, Washington, DC 20037.

Introduction: Relative to migraine generally, chronic migraine (CM) imposes greater disability, healthcare utilization and socioeconomic burden. Six therapies currently possess a credible evidence base for prevention/suppression of CM. This review is intended to provide an assessment of their relative utility, defined as a blend of safety, tolerability and efficacy, focusing in particular on their safety and tolerability. Read More

EMBO Mol Med 2021 Jun 15:e14393. Epub 2021 Jun 15.

Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.

Patients with breast cancer obtain limited clinical benefits from immune checkpoint inhibitors (ICIs), pointing to the existence of multiple immunological alterations that cannot be simultaneously normalized with immunotherapy. Accumulating preclinical evidence suggests that radiation therapy (RT) can be harnessed to sensitize primary and metastatic mouse mammary carcinomas to ICIs. However, various clinical trials combining RT with ICIs in patients with breast cancer documented little cooperativity. Read More

Cancer Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Experimental Therapeutics, National Cancer Center Hospital, Tokyo, Japan.

Comprehensive genomic profiling (CGP) is increasingly used for the routine clinical management of solid cancer. In July 2018, the use of tumor tissue-based CGP assays became available for all solid cancers under the universal health insurance system in Japan. Several restrictions presently exist, such as patient eligibility and limitations on the opportunities to perform such assays. Read More

Microsc Microanal 2021 Jun 15:1-13. Epub 2021 Jun 15.

Pathology Department, Faculty of Veterinary Medicine, Alexandria University, Edfina22758, Egypt.

Mammary cancer is the second most common tumor worldwide. Small animal mammary neoplasms provide an outstanding model to study cancer in humans, as tumors in both share a similar environment, histopathologic features, and biological behavior. This study aims to investigate the percentage and microscopy of breast tumors in affected dogs and cats; its relationship to breed, age, and sex; and the immunohistochemical expression of estrogen receptor (ER), progesterone receptor (PR), Ki-67, and cytokeratin 8. Read More

Palliat Med 2021 Jun 15:2692163211019302. Epub 2021 Jun 15.

Institute for Clinical Evaluative Sciences, Toronto, ON, Canada.

Background: Predictive cancer tools focus on survival; none predict severe symptoms.

Aim: To develop and validate a model that predicts the risk for having low performance status and severe symptoms in cancer patients.

Design: Retrospective, population-based, predictive study. Read More

J Breast Cancer 2021 May 26. Epub 2021 May 26.

Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Purpose: The programmed death ligand 1 (PD-L1) SP142 assay with a 1% immune cell (IC) cutoff is approved for the selection of advanced triple-negative breast cancer (TNBC) patients for atezolizumab treatment. We aimed to evaluate the interobserver concordance of PD-L1 scoring and inter-assay variability of various PD-L1 assays in TNBC.

Methods: Thirty patients with primary TNBC were selected, and SP142, SP263, 22C3, and E1L3N assays were performed. Read More

J Breast Cancer 2021 May 14. Epub 2021 May 14.

Department of Breast Surgery, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, Korea.

Purpose: Raloxifene is a selective estrogen receptor modulator (SERM), and raloxifene treatment for osteoporosis is reimbursable under the Korean National Health Insurance. Evidence suggests that SERMs use reduces the risk of breast cancer in Asian population. Herein, we retrospectively investigated the protective effect of raloxifene on breast cancer rates in Korean population. Read More

J Breast Cancer 2021 May 13. Epub 2021 May 13.

Radioterapia, Dipartimento di Biomedicina e prevenzione, Università degli Studi di Roma Tor Vergata, Roma, Italy.

Salvage mastectomy is currently considered the standard of care for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery (BCS) and postoperative radiotherapy (RT). Alternative treatment options for these patients, such as a second BCS followed by repeated RT, have been suggested. The panel of the Italian Association of Radiotherapy and Clinical Oncology developed clinical recommendations for second BCS followed by re-irradiation over mastectomy alone for women with IBTR using the Grades of Recommendation, Assessment, Development, and Evaluation methodology and the evidence to decision framework. Read More

J Breast Cancer 2021 Apr 29. Epub 2021 Apr 29.

Department of Plastic and Reconstructive Surgery, Korea University Medical Center, Seoul, Korea.

Purpose: Women with large and/or ptotic breasts are generally not considered candidates for nipple-sparing mastectomy because of concerns regarding the high incidence of postoperative complications including ischemic complications. Therefore, we adopted a vertical skin resection technique for nipple-sparing mastectomy, and obtained satisfactory results following immediate autologous breast reconstruction. In this study, we aimed to describe our operative technique and review its outcomes. Read More