50,105 results match your criteria Breast Cancer Male


Radiotherapy in Patients With a Cardiac Implantable Electronic Device.

Am J Cardiol 2020 Aug 15;128:196-201. Epub 2020 May 15.

Unité de Rythmologie, Département de Cardiologie, Hôpital Européen Georges Pompidou, Paris, France; Université de Paris, PARCC, INSERM, F-75015 Paris, France. Electronic address:

Recently, the Heart Rhythm Society published recommendations on management of patients with cardiac implantable electronic device (CIED) who require radiotherapy (RT). We aimed to report the experience of a teaching hospital, and discuss our practice in the context of recently published guidelines. We identified all consecutive CIED recipients (12,736 patients) who underwent RT between March 2006 and June 2017. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.04.045DOI Listing

Diabetic mortality risk among cancer patients in the United State SEER population, 1975-2016.

Endocrine 2020 Jul 8. Epub 2020 Jul 8.

Department of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, PR China.

Background: The focus on diabetic mortality in cancer patients remains superficial. The objective of our study is to identify cancer patients with the highest risk of diabetic mortality compared with other cancer patients and the general US population.

Methods: The representative data of cancer patients dying from diabetes between 1975 and 2016 was retrieved from the Surveillance, Epidemiology, and End Results program. Read More

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http://dx.doi.org/10.1007/s12020-020-02405-2DOI Listing

What happens to cancer survivors attending a structured cancer survivorship clinic? Symptoms, quality of life and lifestyle changes over the first year at the Sydney Cancer Survivorship Centre clinic.

Support Care Cancer 2020 Jul 8. Epub 2020 Jul 8.

Concord Cancer Centre, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW, 2139, Australia.

Background: Sydney Cancer Survivorship Centre (SCSC) clinic provides multidisciplinary care after primary adjuvant treatment, with ~ 40% of attendees continuing follow-up with SCSC.

Methods: SCSC survivors completed measures of symptoms, quality-of-life and lifestyle factors at initial visit (T1), first follow-up (T2) and 1 year (T3). Analyses used mixed effect models, adjusted for age, sex and tumour type. Read More

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http://dx.doi.org/10.1007/s00520-020-05614-7DOI Listing

Bevacizumab-based treatment as salvage therapy in patients with recurrent symptomatic brain metastases.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa038. Epub 2020 Mar 16.

Clinical Cooperation Unit Neuro-Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Background: Salvage treatment for recurrent brain metastases (BM) of solid cancers is challenging due to the high symptomatic burden and the limited local treatment options.

Methods: Patients with recurrent BM with no option for further local therapies were retrospectively identified from BM databases. Bevacizumab-based treatment was initiated as a salvage treatment. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212911PMC

46, XY complete gonadal dysgenesis with pubertal virilisation due to dysgerminoma/gonadoblastoma.

BMJ Case Rep 2020 Jul 7;13(7). Epub 2020 Jul 7.

Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Complete gonadal dysgenesis (CGD) or Swyer syndrome is characterised by sexual infantilism in a phenotypic female with 46, XY karyotype. Patients with gonadal dysgenesis and Y-chromosome material are at a high risk of developing gonadoblastoma and dysgerminoma. A 16-year-old girl presented with progressive virilisation, poor breast development and primary amenorrhea. Read More

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http://dx.doi.org/10.1136/bcr-2020-235501DOI Listing

Risk Factors and Cancer Screening in Myositis.

Rheum Dis Clin North Am 2020 Aug 7;46(3):565-576. Epub 2020 Jun 7.

Myositis Center, Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, 3601 5th Avenue, Suite 2B, Pittsburgh, PA 15261, USA; UPMC Arthritis and Autoimmunity Center, Falk Medical Building, 3601 Fifth Avenue, Suite 2B, Pittsburgh, PA 15213, USA. Electronic address:

The idiopathic inflammatory myopathies, particularly dermatomyositis, are associated with an increased risk of cancer. Lung, ovarian, breast, colon, prostate, and cervical cancers, and hematologic malignancies, are among the most common associated cancers. Risk stratification for cancer in patients with myositis is based on clinical risk factors/red flags, myositis clinical subtypes, and myositis-specific autoantibodies. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.05.006DOI Listing

Methylation Profile of X-Chromosome-Related Genes in Male Breast Cancer.

Front Oncol 2020 17;10:784. Epub 2020 Jun 17.

Dipartimento Scienze della Salute della donna e del Bambino e di Sanità Pubblica, Multidisciplinary Breast Center, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Androgen receptor (AR) has been described to play a prominent role in male breast cancer (MBC). It maps on chromosome X, and recent reports indicate that X-chromosome polysomy is frequent in MBC. Since the response to anti-androgen therapy may depend on AR polysomy and on its overexpression similarly to prostate cancer, the aim of the present study was to investigate the DNA methylation level of and its coregulators, especially those mapped on the X-chromosome, that may influence the activity of AR in MBC. Read More

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http://dx.doi.org/10.3389/fonc.2020.00784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313421PMC

Clinical Learning, Didactic Education, and Research Experiences of Radiation Oncology Resident Physicians in Canada.

J Cancer Educ 2020 Jul 4. Epub 2020 Jul 4.

Division of Radiation Oncology, University of Alberta, Edmonton, AB, Canada.

Changes in the field of radiation oncology (RO) impacts residency training. Assessing trainee experiences is essential to inform curriculum development. We aim to explore gaps and strengths in current Canadian RO training, as we move towards competency-based medical education (CBME). Read More

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http://dx.doi.org/10.1007/s13187-020-01799-xDOI Listing

Breast Cancer in Men: Clinical and Pathological Analysis of 817 Cases.

Am J Mens Health 2020 Jul-Aug;14(4):1557988320908109

Obstetrics and Gynecology Department, State University of Campinas, Brazil.

The objective of the current study was to describe breast cancer cases in men according to age, stage, and histology, calculating risks compared to women. It is a retrospective cross-sectional study of all breast cancer cases of the Hospital Cancer Registry of São Paulo state, Brazil, 2000-2015. Variables were age, sex, stage, and histology. Read More

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http://dx.doi.org/10.1177/1557988320908109DOI Listing

Characterization of the Cancer Spectrum in Men With Germline BRCA1 and BRCA2 Pathogenic Variants: Results From the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).

Authors:
Valentina Silvestri Goska Leslie Daniel R Barnes Bjarni A Agnarsson Kristiina Aittomäki Elisa Alducci Irene L Andrulis Rosa B Barkardottir Alicia Barroso Daniel Barrowdale Javier Benitez Bernardo Bonanni Ake Borg Saundra S Buys Trinidad Caldés Maria A Caligo Carlo Capalbo Ian Campbell Wendy K Chung Kathleen B M Claes Sarah V Colonna Laura Cortesi Fergus J Couch Miguel de la Hoya Orland Diez Yuan Chun Ding Susan Domchek Douglas F Easton Bent Ejlertsen Christoph Engel D Gareth Evans Lidia Feliubadalò Lenka Foretova Florentia Fostira Lajos Géczi Anne-Marie Gerdes Gord Glendon Andrew K Godwin David E Goldgar Eric Hahnen Frans B L Hogervorst John L Hopper Peter J Hulick Claudine Isaacs Angel Izquierdo Paul A James Ramunas Janavicius Uffe Birk Jensen Esther M John Vijai Joseph Irene Konstantopoulou Allison W Kurian Ava Kwong Elisabetta Landucci Fabienne Lesueur Jennifer T Loud Eva Machackova Phuong L Mai Keivan Majidzadeh-A Siranoush Manoukian Marco Montagna Lidia Moserle Anna Marie Mulligan Katherine L Nathanson Heli Nevanlinna Joanne Ngeow Yuen Ye Liene Nikitina-Zake Kenneth Offit Edith Olah Olufunmilayo I Olopade Ana Osorio Laura Papi Sue K Park Inge Sokilde Pedersen Pedro Perez-Segura Annabeth H Petersen Pedro Pinto Berardino Porfirio Miquel Angel Pujana Paolo Radice Johanna Rantala Muhammad U Rashid Barak Rosenzweig Maria Rossing Marta Santamariña Rita K Schmutzler Leigha Senter Jacques Simard Christian F Singer Angela R Solano Melissa C Southey Linda Steele Zoe Steinsnyder Dominique Stoppa-Lyonnet Yen Yen Tan Manuel R Teixeira Soo H Teo Mary Beth Terry Mads Thomassen Amanda E Toland Sara Torres-Esquius Nadine Tung Christi J van Asperen Ana Vega Alessandra Viel Jeroen Vierstraete Barbara Wappenschmidt Jeffrey N Weitzel Greet Wieme Sook-Yee Yoon Kristin K Zorn Lesley McGuffog Michael T Parsons Ute Hamann Mark H Greene Judy A Kirk Susan L Neuhausen Timothy R Rebbeck Marc Tischkowitz Georgia Chenevix-Trench Antonis C Antoniou Eitan Friedman Laura Ottini

JAMA Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Importance: The limited data on cancer phenotypes in men with germline BRCA1 and BRCA2 pathogenic variants (PVs) have hampered the development of evidence-based recommendations for early cancer detection and risk reduction in this population.

Objective: To compare the cancer spectrum and frequencies between male BRCA1 and BRCA2 PV carriers.

Design, Setting, And Participants: Retrospective cohort study of 6902 men, including 3651 BRCA1 and 3251 BRCA2 PV carriers, older than 18 years recruited from cancer genetics clinics from 1966 to 2017 by 53 study groups in 33 countries worldwide collaborating through the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Read More

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http://dx.doi.org/10.1001/jamaoncol.2020.2134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333177PMC

Analysis of Clinical-Pathological Data with Impact on Overall Survival in Male Breast Carcinoma: An International Multi-Institutional Study of 217 Cases.

Chirurgia (Bucur) 2020 May-Jun;115(3):323-333

The aim of this study was to evaluate clinical-pathological parameters with impact on overall survival (OS) in male breast carcinoma (MBC). Methodology: We assessed OS at 5 years and at 10 years respectively, as well as OS according to age, tumor size, microscopic type, histological grade, axillary lymph node status, and molecular profile. Two hundred seventeen cases, with a mean age of 62 (range: 18- 85), right breast involvement (52. Read More

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http://dx.doi.org/10.21614/chirurgia.115.3.323DOI Listing

Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan.

Cancer Med 2020 Jul 1. Epub 2020 Jul 1.

Division of Health Services Research, National Cancer Center, Tokyo, Japan.

Background: The incidence of male breast cancer (MBC), although rare, has shown an increase. However, the current epidemiology of and practice patterns for MBC remain unclear. This study evaluated the characteristics and care patterns for MBC compared with female breast cancer (FBC) in Japan. Read More

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http://dx.doi.org/10.1002/cam4.3267DOI Listing

Transcriptional Profiles of Skeletal Muscle Associated With Increasing Severity of White Striping in Commercial Broilers.

Front Physiol 2020 16;11:580. Epub 2020 Jun 16.

National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Pathum Thani, Thailand.

Development of the white striping (WS) abnormality adversely impacts overall quality of broiler breast meat. Its etiology remains unclear. This study aimed at exploring transcriptional profiles of broiler skeletal muscles exhibiting different WS severity to elucidate molecular mechanisms underlying the development and progression of WS. Read More

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http://dx.doi.org/10.3389/fphys.2020.00580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308426PMC

The dual orexin receptor antagonist daridorexant does not affect the pharmacokinetics of the BCRP substrate rosuvastatin.

Clin Exp Pharmacol Physiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Hegenheimermattweg 91, CH-4123, Allschwil, Switzerland.

Daridorexant is a dual orexin receptor antagonist in clinical development for the treatment of insomnia. Breast-cancer resistant protein (BCRP) is an efflux pump expressed in intestinal epithelium and hepatocytes, contributing to the absorption, distribution, and elimination of drugs and endogenous compounds.In vitro, daridorexant inhibits BCRP with an IC of 3. Read More

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http://dx.doi.org/10.1111/1440-1681.13370DOI Listing

Mortality among US military participants at eight aboveground nuclear weapons test series.

Int J Radiat Biol 2020 Jun 30:1-64. Epub 2020 Jun 30.

Risk Assessment Corporation, Neeses, South Carolina, USA.

: Approximately 235,000 military personnel participated at one of 230 U.S. atmospheric nuclear weapons tests from 1945 through 1962. Read More

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http://dx.doi.org/10.1080/09553002.2020.1787543DOI Listing

Diagnosis, Prognosis, and Management of Breast Cancer in an 81-Year-Old Male Patient.

Cureus 2020 May 25;12(5):e8277. Epub 2020 May 25.

Radiology, University of Texas Medical Branch, Galveston, USA.

Due to the lower rate of breast cancer in men compared to women, there are fewer studies on which to base the treatment of a male patient with breast cancer; and this is further complicated when the patient is part of the elderly population. We report the case of an 81-year-old male who came in for imaging of pulmonary nodules and had an incidental finding of abnormal growth in the breast. Further imaging was performed, and biopsy was completed, confirming invasive ductal carcinoma. Read More

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http://dx.doi.org/10.7759/cureus.8277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317120PMC

Gastroparesis Following Immune Checkpoint Inhibitor Therapy: A Case Series.

Dig Dis Sci 2020 Jun 27. Epub 2020 Jun 27.

Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.

Background: Immune checkpoint inhibitors (ICI) have improved outcomes in patients with various malignancies; however, they can cause immune-related hepatitis and enterocolitis. Patients on ICI may also develop upper gastrointestinal symptoms and undergo measurement of gastric emptying.

Aims: Our aim was to review records of patients with gastroparesis following ICI therapy at two medical centers. Read More

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http://dx.doi.org/10.1007/s10620-020-06440-xDOI Listing

Breast Cancer and Major Deviations of Genetic and Gender-related Structures and Function.

J Clin Endocrinol Metab 2020 Jun 28. Epub 2020 Jun 28.

Department of Pathology, University Medical Center Utrecht, GA Utrecht, The Netherlands.

We have searched the literature for information on the risk of breast cancer (BC) in relation to gender, breast development and gonadal function in the following eight populations: 1) Females with the Turner Syndrome (45,XO); 2) Females and males with Congenital Hypogonadotropic Hypogonadism and the Kallmann Syndrome; 3) Pure gonadal dysgenesis (PGD) in genotypic and phenotypic females and genotypic males (Swyer Syndrome); 4) Males with the Klinefelter Syndrome (47,XXY); 5) Male-to-Female transgenders; 6) Female-to-Male transgenders; 7) Genotypic males, but phenotypic females with the Complete Androgen Insensitivity Syndrome (CAIS), and 8) Females with the Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome (Müllerian agenesis).Based on this search, we have drawn three major conclusions. First, the presence of an Y chromosome protects against the development of BC, even when female size breasts and female level estrogens are present. Read More

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http://dx.doi.org/10.1210/clinem/dgaa404DOI Listing

Treatment of electrical wrist stimulation reduces chemotherapy-induced neuropathy and ultrasound vocalization via modulation of spinal NR2B phosphorylation.

Brain Res Bull 2020 Jun 25;162:237-244. Epub 2020 Jun 25.

Clinical Medicine Division, KoreaInstitute of Oriental Medicine, Daejeon, 34054, Republic of Korea. Electronic address:

Docetaxel, a chemotherapeutic agent used to treat breast cancer, produces a robust painful neuropathy that is aggravated by mechanical and thermal stimuli. This study was undertaken to investigate the analgesic effects of electrical stimulation on docetaxel-induced neuropathic pain in mice and to identify associated changes in ultrasound vocalizations. Peripheral neuropathy was induced with intraperitoneally injected docetaxel (5 mg/kg) on 3 times every 2 days in male ICR mice. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2020.06.016DOI Listing

Effects of Multiple-Dose Administration of Aprocitentan on the Pharmacokinetics of Rosuvastatin.

Clin Pharmacol Drug Dev 2020 Jun 27. Epub 2020 Jun 27.

Department of Clinical Pharmacology, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.

Aprocitentan is an investigational, orally active, dual, endothelin receptor antagonist that targets a novel pathway in the treatment of difficult-to-control (resistant) hypertension. The drug-drug interaction potential of aprocitentan on the breast cancer resistance protein (BCRP) transporter substrate rosuvastatin was investigated in this single-center, open-label, single-sequence study. Twenty healthy male subjects received a single dose of 10-mg rosuvastatin on days 1 and 13 followed by pharmacokinetic and tolerability assessments for up to 120 hours. Read More

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http://dx.doi.org/10.1002/cpdd.815DOI Listing

The correlation between ultrasonographic features, bFGF, and the local invasiveness of thyroid papillary carcinoma.

Medicine (Baltimore) 2020 Jun;99(26):e20644

Department of Ultrasound.

The present study aimed to investigate the correlation between ultrasonographic features, basic fibroblast growth factor (bFGF), and the local invasiveness of papillary thyroid carcinoma (PTC).A total of 350 samples of thyroid nodules were collected. Routine ultrasonography was performed before the operation and routine pathological diagnosis and bFGF detection were performed after the operation. Read More

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http://dx.doi.org/10.1097/MD.0000000000020644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328907PMC

Global Burden of Thyroid Cancer From 1990 to 2017.

JAMA Netw Open 2020 Jun 1;3(6):e208759. Epub 2020 Jun 1.

Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Importance: Thyroid cancer is the most pervasive endocrine cancer worldwide. Studies examining the association between thyroid cancer and country, sex, age, sociodemographic index (SDI), and other factors are lacking.

Objective: To examine the thyroid cancer burden and variation trends at the global, regional, and national levels using data on sex, age, and SDI. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.8759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320301PMC

Are women more afraid than men? Fear of recurrence in couples with cancer - predictors and sex-role-specific differences.

J Psychosoc Oncol 2020 Jun 26:1-16. Epub 2020 Jun 26.

Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hannover, Germany.

Although fear of cancer recurrence (FoR) is one of the major concerns in cancer patients and their partners with approximately 49% reporting moderate to high FoR, few studies investigated predictors and sex-role-specific differences. The aim of the current study was to investigate FoR in couples with different types of cancer and to gain a deeper understanding of sex and role-specific differences and predictors of FoR in patients and partners. Cross-sectional study in Germany. Read More

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http://dx.doi.org/10.1080/07347332.2020.1762823DOI Listing

Subtyping of male breast cancer by PAM50 and immunohistochemistry; a pilot study of a consecutive Danish cohort.

APMIS 2020 Jun 24. Epub 2020 Jun 24.

Research Unit of Pathology, Department of Clinical Research, University of South, Sonderborg, Denmark.

Male breast cancer (MBC) is a rare disease that is still to be fully understood. In female breast cancer molecular subtyping by gene expression has proven its significance. In this study we characterize a consecutive cohort of MBC patients surgically treated from 1997-2017, identified at our institution (N=37), and report the association between molecular subtypes found by a surrogate panel of immunohistochemical (IHC) markers, and the PAM50 signature, as well as Risk-Of-Recurrence score and overall survival for the different subtypes. Read More

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http://dx.doi.org/10.1111/apm.13068DOI Listing

Prevalence and risk factors of nocturnal enuresis among children ages 5-12 years in Xi'an, China: a cross-sectional study.

BMC Pediatr 2020 Jun 22;20(1):305. Epub 2020 Jun 22.

Department of Renal Dialysis, The First Affiliated Hospital of Xi'an Jiaotong University, No.277 West Yanta Road, Xi'an, 710061, Shaanxi, China.

Background: Nocturnal enuresis (NE) has a negative impact on children's health and imposes a long-term burden on families. With economic development and cultural improvements, parents and medical professionals pay more attention to NE. The aim of this study was to investigate the prevalence and risk factors of NE among children ages 5-12 years in Xi'an, China. Read More

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http://dx.doi.org/10.1186/s12887-020-02202-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310244PMC
June 2020
1.918 Impact Factor

Imaging of male breast disease: the good, the bad and the ugly - A pictorial review.

Clin Imaging 2020 Jun 17;68:45-56. Epub 2020 Jun 17.

Grupo Fleury, São Paulo, Brazil; Hospital São Paulo, Universidade Federal de São Paulo, São Paulo, Brazil.

The male breast is affected by a broad spectrum of conditions, ranging from benign to malignant, many of which are similar to those occurring in its female counterpart. Despite the challenge motivated by different imaging characteristic features, correct imaging interpretation in male breast disease may aid at differentiation between benign and suspected conditions, narrow the differential diagnosis and guide subsequent management. The purpose of this review is to showcase a wide array of male breast diseases, discuss their imaging presentations and key features for diagnosis. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.06.025DOI Listing

Intracystic papillary carcinoma of the breast in males: Three case reports.

Medicine (Baltimore) 2020 Jun;99(25):e20278

Department of Breast Surgery, Hangzhou Hospital of Traditional Chinese Medicine.

Rationale: Intracystic papillary breast carcinoma is extremely rare in males with a favorable prognosis. Clinical and mammographic manifestations of IPC are not specific, and no consensus has been reached on its management.

Patient Concerns: Three cases of IPC of the breast in male patients who underwent surgery are presented. Read More

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http://dx.doi.org/10.1097/MD.0000000000020278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310891PMC

Serum concentration of sex hormone-binding globulin in healthy volunteers and patients with breast cancer stratified by sex and age.

Oncol Lett 2020 Jul 21;20(1):364-372. Epub 2020 Apr 21.

Department of Laboratory Medicine, Inha University College of Medicine, Incheon 22332, Republic of Korea.

The objective of the present study was to compare sex hormone-binding globulin (SHBG) levels according to sex (healthy male and female volunteers) and age to determine reference values. Serum SHBG expression levels in patients with breast cancer with different tumor burden states were also determined. A total of 109 samples were obtained from 34 patients in 3 different disease states (non-tumor, localized tumor and systemic metastasis) during follow-up. Read More

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http://dx.doi.org/10.3892/ol.2020.11549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285803PMC
July 2020
0.987 Impact Factor

PBX1 is a valuable prognostic biomarker for patients with breast cancer.

Exp Ther Med 2020 Jul 30;20(1):385-394. Epub 2020 Apr 30.

Center for Precision Medicine, Institute for Translational Medicine, College of Medicine, Qingdao University, Qingdao, Shandong 266021, P.R. China.

Pre-B-cell leukemia transcription factor (PBX) proteins have important roles in the development of numerous organs. To date, four members of the PBX family have been identified to be involved in human cancer but little is known about their expression patterns and precise functions in breast cancer (BC) progression. The aim of the present study was to determine whether they have the potential to be prognostic biomarkers in patients with BC. Read More

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http://dx.doi.org/10.3892/etm.2020.8705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286203PMC

Breast Cancer Survivors' Unmet Needs After Completion of Radiation Therapy Treatment.

Oncol Nurs Forum 2020 07;47(4):436-445

Medical University of South Carolina.

Purpose: To identify the unmet needs of breast cancer survivors after radiation therapy.

Participants & Setting: Patients who received radiation therapy for unilateral breast cancer with six months or longer of follow-up and exhibited no disease progression were eligible for selection to a study conducted at an outpatient radiation therapy academic practice in the southeastern United States.

Methodologic Approach: A qualitative descriptive study was undertaken using semistructured interviews, framed by the five domains of the Survivor Unmet Needs Survey and analyzed using an iterative inductive and deductive process. Read More

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http://dx.doi.org/10.1188/20.ONF.436-445DOI Listing

A Germline PALB2 Pathogenic Variant identified in a Pediatric High Grade Glioma.

Cold Spring Harb Mol Case Stud 2020 Jun 18. Epub 2020 Jun 18.

University of Pennsylvania, Children's Hospital of Philadelphia;

PALB2 (partner and localizer of BRCA2) gene encodes a protein that co-localizes with BRCA2 in nuclear foci and likely permits the stable intra-nuclear localization and accumulation of BRCA2. PALB2 plays a critical role in maintaining genome integrity through its role in the Fanconi anemia and homologous recombination DNA repair pathways. It has a known loss of function disease mechanism. Read More

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http://dx.doi.org/10.1101/mcs.a005397DOI Listing

Perspective of Oncology Patients During COVID-19 Pandemic: A Prospective Observational Study From India.

JCO Glob Oncol 2020 06;6:844-851

Department of Medical Oncology, Tata Medical Center, Kolkata, West Bengal, India.

Purpose: The coronavirus disease 2019 (COVID-19) pandemic has imposed a unique challenge to oncology patients and their treatment. There is no study related to the patients' preference for systemic therapy during this pandemic. We have conducted a prospective study to analyze that aspect. Read More

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http://dx.doi.org/10.1200/GO.20.00172DOI Listing

Orbital metastasis in a male patient after seven years from breast cancer diagnosis.

Breast J 2020 Jun 15. Epub 2020 Jun 15.

Department of Ophthalmology, Humanitas Research Hospital - IRCCS, Rozzano/Milano, Italy.

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http://dx.doi.org/10.1111/tbj.13937DOI Listing

[A Case of Synchronous Bilateral Male Breast Cancer].

Gan To Kagaku Ryoho 2020 Jun;47(6):973-976

Dept. of Endocrine and Breast Surgery, University Hospital Kyoto Prefectural University of Medicine.

A 71-year-old man with right and left mammary tumor came to our hospital. Using needle biopsy, we diagnosed both tumors as ER-positive, PgR-positive, and HER2(1+)invasive ductalcarcinoma. We performed radicalmastectomy and axillary dissection. Read More

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Impact of Adjuvant Radiation Therapy in Patients With Male Breast Cancer: A Multicenter International Analysis.

Adv Radiat Oncol 2020 May-Jun;5(3):345-349. Epub 2020 Feb 20.

Department of Radiotherapy and Radiation Oncology, Franziskus Hospital Bielefeld, Bielefeld, Germany.

Purpose: Breast cancer in men accounts for approximately 1% of all breast cancers. Breast cancer trials have routinely excluded men. The aim of this analysis was to determine the effect of different treatment factors, in particular, postoperative radiation therapy (RT) on long-term outcomes. Read More

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http://dx.doi.org/10.1016/j.adro.2020.01.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276673PMC
February 2020

Male Breast Cancer: Clinicopathological, Immunohistochemical and Radiological Study.

Turk Patoloji Derg 2020 Jun 11. Epub 2020 Jun 11.

Department of Pathology, Başkent University, Faculty of Medicine, ADANA, TURKEY.

Objective: To evaluate the pathological and radiological features, immunohistochemical profile and treatment methods of primary male breast carcinoma cases diagnosed at our center.

Material And Method: The pathology archive between 2006 and 2019 was reviewed and the data of 27 male patients diagnosed as primary breast cancer were retrospectively evaluated.

Results: The age of the patients ranged between 40-86 years. Read More

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http://dx.doi.org/10.5146/tjpath.2020.01490DOI Listing

An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data.

Pharmacol Res Perspect 2020 Jun;8(3):e00599

PK Sciences (ADME), Novartis Institutes for Biomedical Research, Basel, Switzerland.

Ribociclib (LEE011, Kisqali ®) is a highly selective small molecule inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which has been approved for the treatment of advanced or metastatic breast cancer. A human ADME study was conducted in healthy male volunteers following a single oral dose of 600 mg [ C]-ribociclib. Mass balance, blood and plasma radioactivity, and plasma ribociclib concentrations were measured. Read More

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http://dx.doi.org/10.1002/prp2.599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287031PMC

Male bilateral risk-reducing mastectomy: Report of a case.

Breast J 2020 Jun 9. Epub 2020 Jun 9.

Division of Breast Surgical Oncology, Department of Medical and Surgical, Maternal-Infantile and Adult Sciences, University Hospital of Modena, Modena, Italy.

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http://dx.doi.org/10.1111/tbj.13928DOI Listing

Comparing Surgeon Approaches to Patient-Centered Cancer Care Using Vignette Methodology.

J Gastrointest Surg 2020 Jun 9. Epub 2020 Jun 9.

Department of Surgery, The Ohio State University Wexner Medical Center, 395 W. 12th Ave., Suite, Columbus, OH, 670, USA.

Background: We sought to characterize surgeon perceptions of patient attachment-related behaviors relative to patient-centered approaches during treatment decision-making within the clinical encounter.

Methods: An online survey including clinical vignettes was sent to board-certified surgeons to assess their approach to patient-centered treatment decision-making. Within these vignettes, patient behaviors associated with attachment styles (secure vs 3 insecure subtypes: avoidant, anxious, and fearful) were fixed and patient factors (age, race, occupation, and gender) were randomized. Read More

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http://dx.doi.org/10.1007/s11605-020-04661-zDOI Listing

Adherence to National Comprehensive Cancer Network Guidelines for testing among high risk breast Cancer patients: a retrospective chart review study.

Hered Cancer Clin Pract 2020 6;18:13. Epub 2020 Jun 6.

Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215 USA.

Background: Testing for variants can impact treatment decisions for breast cancer patients and affect surveillance and prevention strategies for both patients and their relatives. National Comprehensive Cancer Network (NCCN) guidelines recommend testing for patients at heightened risk of pathogenic variant. We examined the testing rate among high risk breast cancer patients treated in community oncology practices. Read More

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http://dx.doi.org/10.1186/s13053-020-00144-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275608PMC

Association between chronic kidney disease and mortality in stage IV cancer.

Int J Clin Oncol 2020 Jun 8. Epub 2020 Jun 8.

Department of Nephrology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

Background: Chronic kidney disease (CKD) is known to be associated with cancer mortality. However, no study has considered the well-known cancer prognostic factors, ECOG Performance Status (PS) and cancer treatment, as confounding factors. We assessed the independent relationship between CKD and cancer death in stage IV cancer patients. Read More

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http://dx.doi.org/10.1007/s10147-020-01715-9DOI Listing

Incidence and prognosis of liver metastasis at diagnosis: a pan-cancer population-based study.

Am J Cancer Res 2020 1;10(5):1477-1517. Epub 2020 May 1.

KU Leuven, Campus Gasthuisberg, Faculty of Medicine Leuven 3000, Belgium.

Metastasis is a major cause of cancer-related death and liver metastasis (LM) is a distinct type for its relatively good prognosis after timely treatment for selected patients. However, a generalizable estimation of incidence and prognosis of LM is lacking. Cancer patients with known LM status in the Surveillance, Epidemiology and End Results database were enrolled in the present study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269791PMC

Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.

Clin Pharmacokinet 2020 Jun 5. Epub 2020 Jun 5.

Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Str. 65, 88397, Biberach an der Riss, Germany.

Background And Objective: A novel cocktail containing four substrates of key drug transporters was previously optimized to eliminate mutual drug-drug interactions between the probes digoxin (P-glycoprotein substrate), furosemide (organic anion transporter 1/3), metformin (organic cation transporter 2, multidrug and toxin extrusion protein 1/2-K), and rosuvastatin (organic anion transporting polypeptide 1B1/3, breast cancer resistance protein). This clinical trial investigated the effects of four commonly employed drug transporter inhibitors on cocktail drug pharmacokinetics.

Methods: In a randomized open-label crossover trial in 45 healthy male subjects, treatment groups received the cocktail with or without single oral doses of rifampin, verapamil, cimetidine or probenecid. Read More

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http://dx.doi.org/10.1007/s40262-020-00907-wDOI Listing

The Effect of Coronavirus (COVID-19) on Breast Cancer Teamwork: A Multicentric Survey.

In Vivo 2020 Jun;34(3 Suppl):1685-1694

Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.

Background/aim: Despite the large amount of clinical data available of Coronavirus-19 (COVID-19), not many studies have been conducted about the psychological toll on Health Care Workers (HCWs).

Patients And Methods: In this multicentric descriptive study, surveys were distributed among 4 different Breast Cancer Centers (BCC). BCCs were distinguished according to COVID-19 tertiary care hospital (COVID/No-COVID) and district prevalence (DP) (High vs. Read More

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http://dx.doi.org/10.21873/invivo.11962DOI Listing
June 2020
1.148 Impact Factor

Retrospective Analysis of HER2+ Breast Cancer Outcomes at a County Hospital: Do Published Outcomes Hold up in the Real World?

Cureus 2020 May 2;12(5):e7937. Epub 2020 May 2.

Hematology & Oncology, Olive View - University of California Los Angeles (UCLA) Medical Center, Los Angeles, USA.

Introduction: Landmark trials repeatedly demonstrate that pertuzumab and trastuzumab plus standard chemotherapy have the best outcomes in human epidermal growth factor receptor 2 (HER2) positive breast cancer in the neoadjuvant, adjuvant, and metastatic setting. However, many of these multicenter landmark trials lack diversity and studied largely Caucasian populations. Our goal is to address this under-representation of minorities, and compare pathologic complete response (pCR) rates in our predominantly Hispanic population with HER2 positive breast cancer receiving the same neoadjuvant chemotherapy (NACT) at Olive View-UCLA Medical Center (OVMC) to that of pCR rates observed in the TRYPHAENA trial. Read More

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http://dx.doi.org/10.7759/cureus.7937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266367PMC

Risk of second primary breast cancer among cancer survivors: Implications for prevention and screening practice.

PLoS One 2020 4;15(6):e0232800. Epub 2020 Jun 4.

Department of Epidemiology and Biostatistics, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Second primary breast cancer (SPBC) is becoming one of the major obstacles to breast cancer (BC) control. This study was aimed to determine the trend of SPBC incidence over time and the risk of developing SPBC in site-specific primary cancer survivors in the United States. The Surveillance, Epidemiology, and End Results (SEER) 13 registry (1992-2015) was used to identify SPBC patients with previous malignancies. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0232800PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272050PMC

Pharmacological management of male breast cancer.

Expert Opin Pharmacother 2020 Jun 4:1-12. Epub 2020 Jun 4.

Division of Early Drug Development, European Institute of Oncology (IEO), IRCCS , Milan, Italy.

Introduction: Despite its rarity, male breast cancer shows a steadily rising incidence. Given the absence of ad hoc prospective randomized clinical trials, treatment strategies are based on extrapolation from female breast cancer recommendations or solely on population-based data.

Areas Covered: This review discusses the current treatment landscape for male breast cancer in the adjuvant and in the metastatic setting. Read More

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http://dx.doi.org/10.1080/14656566.2020.1763305DOI Listing

A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma.

MethodsX 2020 17;7:100921. Epub 2020 May 17.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, China.

Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates. The advantages of this mouse model are as follows:•This method developed a H11 knock-in HCC mouse model by crossing H11 heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. Read More

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http://dx.doi.org/10.1016/j.mex.2020.100921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256637PMC

Efficacy and Safety of Thalidomide for Chemotherapy-induced Nausea and Vomiting.

J Cancer 2020 18;11(15):4560-4570. Epub 2020 May 18.

Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

: A substantial number of cancer patients discontinue chemotherapy due to severe chemotherapy-induced nausea and vomiting (CINV). This study aimed to evaluate the efficacy and safety of thalidomide (THD) in CINV. : We searched different databases to identify related studies that investigated the efficacy and safety of THD in CINV. Read More

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http://dx.doi.org/10.7150/jca.45678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255358PMC

Occurrence of Seizures Prior to Single-fraction Radiosurgery or Multi-fraction Stereotactic Radiotherapy in Patients With Very Few Brain Metastases.

Anticancer Res 2020 Jun;40(6):3499-3504

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Seizures represent a major problem for patients with brain metastases. This study evaluated the role of seizures in patients receiving single-fraction radiosurgery (SRS) or multi-fraction stereotactic radiotherapy (FSRT).

Patients And Methods: This retrospective study included 195 patients receiving SRS (n=164) or FSRT (n=31) alone for one to three brain metastases. Read More

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http://dx.doi.org/10.21873/anticanres.14337DOI Listing