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Benef Microbes 2019 Apr 23:1-14. Epub 2019 Apr 23.

2 Clinical Research Center, Schauenburgerstraβe 116, 24118 Kiel, Germany.

We aimed at assessing the evidence for an effect on vaginal dysbiosis by oral administration of a mixture of strains isolated from vaginal microbiota. For this purpose, we systematically reviewed the literature for randomised clinical trials (RCTs) in which the effect of oral administration of a mixture of four strains ( LbV 88 (DSM 22566), LbV 150N (DSM 22583), LbV 116 (DSM 22567) and LbV96 (DSM 22560)) on vaginal dysbiosis was examined based on Nugent score. Four RCTs were identified: a double-blind (DB)-RCT in 60 male-to-female transsexual women with neovagina; an open label RCT in 60 pregnant women with herpes virus infection; a DB-RCT in 36 women with bacterial vaginosis; a DB-RCT in 22 postmenopausal breast cancer patients receiving chemotherapy. Read More

Case Rep Oncol 2019 Jan-Apr;12(1):248-259. Epub 2019 Mar 19.

Department of Head and Neck Surgery, Vietnam National Cancer Hospital, Hanoi, Vietnam.

Mucoepidermoid carcinomas (MECs) are generally found in salivary gland, but they have also been mentioned in other organs such as the larynx, esophagus, breast. MECs are considered to be a low-grade carcinoma and their occurrence in the thyroid is extremely rare. We present a 54-year-old male patient admitted to our clinic, complaining about having back pains for approximately three months. Read More

BMJ Case Rep 2019 Apr 20;12(4). Epub 2019 Apr 20.

Department of Surgery, Salmaniya Medical Complex, Manama, Bahrain.

Male breast cancer is a rare but important condition accounting for only 1% of breast cancer worldwide and less than 1% of all male malignancies. Occult male breast cancer is an extremely rare type of male breast cancer that manifests as axillary metastases without an identifiable breast lesion. We report a case of triple-negative occult male breast cancer who underwent modified radical mastectomy. Read More

Am J Case Rep 2019 Apr 17;20:531-536. Epub 2019 Apr 17.

Department of General Surgery, Surgical Oncology Unit, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

BACKGROUND Male breast cancer is rare, accounting for approximately 1% of all malignancies in men. The lack of awareness of this rare cancer results in delayed diagnosis and its aggressive behavior can result in poor prognosis. This report is of a case of locally advanced, high-grade breast cancer in a 59-year-old man who was reluctant to undergo diagnostic procedures, and describes the approach to clinical management. Read More

Early Hum Dev 2019 May 12;132:58-65. Epub 2019 Apr 12.

School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia 750004, China; Key Laboratory of Fertility Preservation and Maintenance of the Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia 750004, China. Electronic address:

Objectives: 2D:4D is an anthropometric indicator that may reflect the level of intrauterine sexual hormone exposure before birth. The aromatase gene (CYP19A1) mainly encodes cytochrome P450 aromatase, a key enzyme that catalyzes the conversion of androgens to estrogens in vivo and affects the development of 2D:4D. Studying the association between six single-nucleotide polymorphisms (SNPs) in CYP19A1 and digit ratios in the normal population of China will provide some basis for the biological basis of digit ratio development and promote the practical application of digit ratios. Read More

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):226-231

Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, Delhi, India.

Background: Male breast cancers (MBCs) are uncommon and account for 1% of all breast cancers. Medical conditions that increase the estrogen to testosterone ratio are implicated as the risk factors. Morphologically similar, but MBCs have biological differences compared with female breast cancer (FBC). Read More

Anticancer Res 2019 Apr;39(4):2061-2067

Department of Surgery, Kochi Medical School, Kochi, Japan.

Background/aim: The aim of this study was to determine the natural history of benign thyroid nodules using ultrasonography.

Patients And Methods: The records of 223 patients with benign thyroid nodules treated at the Kochi Medical School from 2010 to 2012 were reviewed retrospectively. Repeated ultrasonography was performed, and the findings were directly compared with previous images. Read More

Indian J Cancer 2019 Jan-Mar;56(1):37-40

Department of Medical Oncology, Cancer Institute (WIA), Adyar, Chennai, Tamil Nadu, India.

Background: Male breast cancers (MBC) account for 1% of all breast cancers. Neoadjuvant concurrent chemoradiation (CTRT) is not the standard of care for treating breast cancer. However, in our center, it has been routinely used in patients with locally advanced breast cancer to downsize the tumor and make it amenable to surgery. Read More

Psychother Psychosom Med Psychol 2019 Apr 3. Epub 2019 Apr 3.

Department für Psychische Gesundheit, Abteilung für Medizinische Psychologie und Medizinische Soziologie, Universitatsklinikum Leipzig, Leipzig.

Background: Causal attributions can result in self-incrimination and psychosocial burden. Therefore, the present study assessed assumptions about subjective causes of cancer and examines their relationships with social factors and perceived stigmatization.

Methods: In a bicentric study, 858 patients with breast, colon, prostate or lung cancer were given standardized questionnaires. Read More

J Breast Cancer 2019 Mar 28;22(1):141-148. Epub 2018 Dec 28.

Department of Clinical Oncology, Cairo Oncology Center, Cairo, Egypt.

The luteinizing hormone-releasing hormone/androgen receptor (LHRH/AR) pathway is a promising treatment target in a subgroup of female patients with triple-negative breast cancer (TNBC). However, very little is known about the efficacy of this strategy in male patients with TNBC. In this report, we describe a male patient with AR-positive TNBC who was successfully treated using an LHRH agonist after pretreatment with several lines of chemotherapy and achieved a durable response. Read More

Int J Environ Res Public Health 2019 Apr 1;16(7). Epub 2019 Apr 1.

The George Institute for Global Health, University of Oxford, Oxford OX1 2BQ, UK.

Age-standardised rates of cardiovascular disease (CVD) are substantially higher in men than women. This explains why CVD has traditionally been seen as a "man's problem". However, CVD is the leading cause of death in women, worldwide, and is one of the most common causes of disability-adjusted life-years lost. Read More

Mil Med 2019 Apr 2. Epub 2019 Apr 2.

Department of Surgery, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.

Male breast cancer (MBC) is rare and consequently understudied. Here we present the case of contralateral breast cancer in a male patient nearly a quarter century following his initial breast cancer diagnosis and treatment. The epidemiology, risk factors, diagnosis, characterization, treatment, and prognosis of male breast cancer are reviewed. Read More

J Clin Med Res 2019 Apr 18;11(4):275-282. Epub 2019 Mar 18.

Post-Graduate Program of Health Science, Federal University of Santa Maria (UFSM), Santa Maria, Rio Grande do Sul, Brazil.

Background: Cancer is a public health problem, especially in developing countries. In order to establish effective measures for the cancer control, there is a need for quality information, thus enabling a better understanding of the disease and its determinants, formulation of causal hypotheses, evaluation of the technological advances applied to prevention and treatment as well as the effectiveness of health care. The objective of the study was to investigate the prevalence of solid neoplasms diagnosed between the years 2011 to 2016 and treated at the Oncology Department of the University Hospital of Santa Maria and the existing oncological context. Read More

Cancer Nurs 2019 Mar 29. Epub 2019 Mar 29.

Author Affiliations: Department of Nursing, University College Copenhagen (Mrs Egestad); Departments of Oncology (Mrs Gyldenvang) and Oncology and Hematology (Dr Jarden), Copenhagen University Hospital, Rigshospitalet; and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen (Dr Jarden), Denmark.

Background: Relatives of patients with cancer are at risk of experiencing changes to their everyday life, health, and quality of life. Partners of men with breast cancer may face certain challenges regarding their need for information, care, and support.

Objective: The purpose was to explore the experiences of the partners of men with breast cancer in relation to care, information, and emotional support and to explore how men with breast cancer impact the partners' everyday life. Read More

P R Health Sci J 2019 Mar;38(1):64-67

Department of Pathology and Laboratory Medicine, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico; Administración de Servicios Médicos de Puerto Rico, San Juan, Puerto Rico.

Leptomeningeal carcinomatosis (LMC) refers to the infiltration of malignant cells in the pia-arachnoids. LMC is undiagnosed until autopsy in about 20% of cases. A nonspecific neurologic symptomatology makes diagnosis challenging; especially in the scenario of unknown malignancy. Read More

Endocr Relat Cancer 2019 Mar 1. Epub 2019 Mar 1.

C Moelans, Pathology, University Medical Center Utrecht, Utrecht, Netherlands.

Ductal carcinoma in situ (DCIS) of the male breast is very rare and has hardly been studied molecularly. In males, we compared methylation status of 25 breast cancer-related genes in pure DCIS (N=18) and invasive breast carcinoma (IBC) with adjacent DCIS (DCIS-AIC) (N=44) using methylation-specific multiplex ligation-dependent probe amplification. Results were compared to female breast cancer (BC). Read More

JAMA Oncol 2019 Mar 28. Epub 2019 Mar 28.

Department of Pediatric Oncology, Emma Children's Hospital, Amsterdam University Medical Center (UMC), University of Amsterdam, Amsterdam, the Netherlands.

Importance: Survivors of childhood cancer (CCSs) face risk of developing subsequent tumors. Solid benign tumors may be cancer precursors; benign tumors and cancers may share etiologic factors. However, comprehensive data on the risk for solid benign tumors are lacking. Read More

Oman Med J 2019 Mar;34(2):126-130

Department of Public Health, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.

Objectives: We sought to evaluate the trends in age-standardized incidence rates of cancer by gender, age, and types in the Sivas province of Turkey from 2004 to 2014.

Methods: Data were obtained from the Sivas Public Health Department Cancer Unit and the Cumhuriyet University Hospital Cancer Record Unit for the studied period. Data were presented as incidence rates by age, gender, and cancer site using world age-standardized incidence rate (ASR-W) per 10 populations. Read More

Nat Commun 2019 03 27;10(1):1387. Epub 2019 Mar 27.

Department of Molecular Medicine, CMRI, Exosome Convergence Research Center (ECRC), School of Medicine, Kyungpook National University, Daegu, 41944, Republic of Korea.

Inhibitors of the secretion of cancer exosomes, which promote cancer progression and metastasis, may not only accelerate exosome biology research but also offer therapeutic benefits for cancer patients. Here we identify sulfisoxazole (SFX) as an inhibitor of small extracellular vesicles (sEV) secretion from breast cancer cells through interference with endothelin receptor A (ETA). SFX, an FDA-approved oral antibiotic, showed significant anti-tumor and anti-metastatic effects in mouse models of breast cancer xenografts, the reduced expression of proteins involved in biogenesis and secretion of sEV, and triggered co-localization of multivesicular endosomes with lysosomes for degradation. Read More

World J Surg Oncol 2019 Mar 27;17(1):59. Epub 2019 Mar 27.

Neuro-oncology Clinic, National Cancer Center, Goyang, Republic of Korea.

Background: Leptomeningeal carcinomatosis (LMC) is frequently associated with hydrocephalus, which quickly devastates the performance of the patient. Cerebrospinal fluid (CSF) shunt is a widely accepted treatment of choice, but the clinical outcomes in patients with LMC are not well studied. This study aimed to examine the efficacy of a CSF shunt in patients with LMC. Read More

Zhonghua Zhong Liu Za Zhi 2019 Mar;41(3):235-240

Department of Breast Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.

To investigate the clinical characteristics, therapy modality and prognosis of primary breast diffuse large B-cell lymphoma(PB-DLBCL). A total of 68 patients with PB-DLBCL treated in Tianjin Medical University Cancer Institute and Hospital were enrolled between January 1, 2004 and January 31, 2017. Clinicopathological data were retrospectively analyzed. Read More

Gan To Kagaku Ryoho 2019 Feb;46(2):309-311

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

Breast cancer in male is comparatively rare. We encountered a case of breast cancer in an elderly male who was treated with consideration of age. A 78-year-old male consulted our hospital with a lump on his right breast. Read More

Support Care Cancer 2019 Mar 26. Epub 2019 Mar 26.

National Poison Centre, Universiti Sains Malaysia, 11800, Gelugor, Penang, Malaysia.

Purpose: This observational study aimed to compare the outcome and health-related quality of life (HRQOL) amongst breast cancer patients using Chinese herbal medicine (CHM) and those not using CHM during chemotherapy.

Methods: A prospective, non-randomised longitudinal study was conducted in two government integrated hospitals over an 8-month period. Early-stage breast cancer patients who were (1) either already using complementary and alternative medicine (CAM) or not and (2) who were on a regime of 5-fluorouracil, epirubicin, and cyclophosphamide were included in the study. Read More

J Trace Elem Med Biol 2019 May 25;53:16-21. Epub 2019 Jan 25.

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

The relationship between iodine intake and clinicopathologic characteristics of papillary thyroid cancer (PTC) is unclear. We aim to investigate the relationship between iodine intake and central lymph node metastasis (CLNM) of PTC. A total of 4040 consecutive patients with PTC receiving thyroidectomy and central lymph node dissection were enrolled from 2013 to 2018. Read More

Cochrane Database Syst Rev 2019 Mar 26;3:CD012387. Epub 2019 Mar 26.

Research Group Health Care, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Limburg, Belgium, 3500.

Background: Receiving a diagnosis of cancer and the subsequent related treatments can have a significant impact on an individual's physical and psychosocial well-being. To ensure that cancer care addresses all aspects of well-being, systematic screening for distress and supportive care needs is recommended. Appropriate screening could help support the integration of psychosocial approaches in daily routines in order to achieve holistic cancer care and ensure that the specific care needs of people with cancer are met and that the organisation of such care is optimised. Read More

Endocrinol Diabetes Metab Case Rep 2019 Mar 23;2019. Epub 2019 Mar 23.

St. Vincent's University Hospital and University College Dublin, Dublin, Ireland.

Context Adrenal incidentalomas (AI) represent an increasingly common problem in modern endocrine practice. The diagnostic approach to AIs can be challenging and occasionally reveals surprising features. Here we describe two rare cases of complex adrenal lesions consisting of phaeochromocytomas with synchronous metastases from extra-adrenal primaries. Read More

Tumori 2019 Mar 25:300891619837896. Epub 2019 Mar 25.

2 Editorial board, Epidemiologia e Prevenzione, Milan, Italy.

Background:: The proportion of patients cured of cancer is usually estimated with cure models assuming they have the same death risk as the general population. These patients, even when cured, often maintain an extra death risk compared to the overall population. Our aims were to estimate this extra risk, and to take it into account in estimating cure proportions and relative survival (RS). Read More

Acta Cytol 2019 Mar 22:1-9. Epub 2019 Mar 22.

Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA,

Objective: Differentiation between gynecomastia, a common cause of male breast enlargement, and breast cancer is crucial for appropriate management. Fine-needle aspiration biopsy has been shown to be sensitive and specific in assessing female breast lesions, comparable to core needle biopsy. Few such studies have been conducted in men. Read More

Int J Surg Case Rep 2019 Feb 26;57:60-62. Epub 2019 Feb 26.

Department of Surgery, Maimonides Medical Center, Brooklyn NY, United States.

Introduction: Male breast cancer is a rare disease. Although epidemiologic and genetic factors are associated with male breast cancer, hormonal factors may also play a role.

Case Presentation: We report the case of a 39-year-old BRCA negative male patient taking a sexual performance enhancement supplement who presented with worsening asymmetric gynecomastia and unilateral spontaneous bloody nipple discharge and was found to have ductal carcinoma in-situ. Read More

Rev Esp Patol 2019 Apr - Jun;52(2):72-75. Epub 2018 Aug 1.

Registro de Tumores, Hospital Universitario La Paz, Madrid, España.

Introduction: We present the case for the establishment of hospital tumour registries in order to facilitate the use of epidemiological data and the development of preventive policies.

Material And Methods: Retrospective descriptive analysis of the data of the tumour registry of the Hospital "La Paz" including tumoral location (ICD-O), diagnostic method, tumour grade and treatment.

Results: 1987 cases were included. Read More

J Immigr Minor Health 2019 Mar 21. Epub 2019 Mar 21.

Department of Family Medicine and Community Health, University of Minnesota, 717 Delaware Street, Minneapolis, MN, 55414, USA.

Somali American women have low rates of breast and cervical screening. This research aimed to test the feasibility and impact of religiously tailored workshops involving Somali American Muslim women and male imams to improve intention to undergo breast or cervical cancer screening. Religiously tailored workshops addressing cancer screening (each approximately 3 h in length) were conducted with 30 Somali American women and 11 imams. Read More

J Biochem Mol Toxicol 2019 Mar 21:e22318. Epub 2019 Mar 21.

Department of Pharmacology and Toxicology, Rutgers, The State University of New Jersey, Ernest Mario School of Pharmacy, Piscataway, New Jersey.

Multidrug resistance protein 1 (MDR1) and breast cancer resistance protein (BCRP) protect the brain by restricting the passage of chemicals across the blood-brain barrier. Prior studies have demonstrated the epigenetic regulation of MDR1 and BCRP in cancer cells treated with histone deacetylase (HDAC) inhibitors that enhance histone acetylation and gene transcription. In the present study, we tested the in vivo effects of two HDAC inhibitors, valproic acid (VPA; 400 mg/kg) and apicidin (5 mg/kg), on Mdr1 and Bcrp transporter expression in brain regions of adult male mice injected intraperitoneally daily for 7 days. Read More

Microsurgery 2019 Mar 19. Epub 2019 Mar 19.

International Lymphedema Center, Hiroshima University Hospital, Hiroshima, Japan.

Men, as well as women may develop breast lymphedema following breast cancer treatment. Microsurgically performed lymphovenous anastomosis (LVA), an effective treatment for lymphedema of the extremities, has also been successfully applied to breast lymphedema. Here we report the first case of breast lymphedema secondary to male breast cancer, treated with supermicrosurgical LVA. Read More

Clin Cancer Res 2019 Mar 19. Epub 2019 Mar 19.

International Cancer Prevention Institute, Epalinges, Switzerland.

The impact of sex hormones on anticancer immunity deserves attention due to the importance of the immune system in cancer therapy and the recognition of sex differences in immunity. Cancer is ultimately the result of failed immune surveillance, and the diverging effects of male and female sex hormones on anticancer immunity could contribute to the higher cancer incidence and poorer outcome in men. Estrogens and androgens affect the number and function of immune cells, an effect that depends on cell type, tumor microenvironment, and the age and reproductive status of the individual. Read More

Pharm Res 2019 Mar 18;36(5):68. Epub 2019 Mar 18.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: Chemotherapy as an important tool for cancer treatment faces many obstacles such as multidrug resistance and adverse toxic effects on healthy tissues. Drug delivery systems have opened a new window to overcome these problems.

Methods: A polyelectrolyte carboxymethyl cellulose polymer as a magnetic nanocarrier was synthesized for enhancing delivery and uptake of doxorubicin in MCF7 breast cancer cells and decreasing the adverse toxic effects to healthy tissues. Read More

Cancer Imaging 2019 Mar 18;19(1):14. Epub 2019 Mar 18.

UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, CA, USA.

Purpose: To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibility contrast (DSC) perfusion MRI.

Methods: MRI imaging was retrospectively assessed on one hundred and fourteen (N = 114) brain metastases including breast (n = 27), non-small cell lung cancer (NSCLC, n = 43) and 'other' primary tumors (n = 44). Based on 114 patient's MRI scans, a total of 346 individual contrast enhancing tumors were manually segmented. Read More

Cancer Manag Res 2019 1;11:1959-1968. Epub 2019 Mar 1.

Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China,

Objective: Accumulating evidences showed some positive relations between myocardial infarction (MI) and new onset cancer. We aim to investigate whether MI is associated with an increased risk of incident cancer.

Methods: A comprehensive literature list was identified from MEDLINE, Embase, and Web of Science databases from inception until October 2018. Read More

Arch Sex Behav 2019 Mar 11. Epub 2019 Mar 11.

School of Social Work, University of Alabama, Tuscaloosa, AL, 35486, USA.

The purpose of the study was to determine whether veteran students and non-veteran students differed in their sexual behaviors and health practices and, furthermore, whether or not those differences were gender specific. Demographic characteristics of the study sample were explored by calculating frequencies and percentages by military service status. Research questions were explored with maximum likelihood multiple logistic regression. Read More

Front Oncol 2019 27;9:111. Epub 2019 Feb 27.

Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, United States.

We sought to analyze the long-term follow-up of patients treated with hypofractionated, stereotactic radiotherapy (HSRT) for oligometastases from malignancies other than breast or prostate cancer. From 2001 to 2006, 82 cancer patients with 1-5 radiographically apparent metastatic lesions (in 1-3 organs) from primary sites other than breast or prostate cancer, were enrolled on a prospective study of HSRT. Freedom from widespread metastasis (FFWM) was defined from date of enrollment until death, an event (i. Read More

World J Surg Oncol 2019 Mar 14;17(1):48. Epub 2019 Mar 14.

Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima, 890-8520, Japan.

Background: Development of an anastomotic stricture following rectal cancer surgery is not uncommon. Such strictures are usually managed by manual or instrumental dilatation techniques that are often insufficiently effective, as evidenced by the high recurrence rate. Various surgical procedures using minimally invasive approaches have also been reported. Read More

Oncol Lett 2019 Mar 4;17(3):3362-3370. Epub 2019 Feb 4.

Research Centre-Molecular Oncology Group-CI, Instituto Português de Oncologia do Porto Francisco Gentil, Porto 4200-072, Portugal.

The accomplishment of successful pain treatment requires evaluation, characterization and quantification. The present study characterized pain and survival in a cohort of patients with cancer with bone metastasis who were treated with intravenous bisphosphonates. A total of 84 patients self-completed the Brief Pain Inventory (BPI) and 36-Item Short Form Survey (SF-36), between November 2010 and March 2011 with a 5-year survival follow-up as a surrogate marker of cancer burden. Read More

Br J Cancer 2019 Apr 14;120(8):848-854. Epub 2019 Mar 14.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.

Background: Individuals with a family history of cancer may be at increased risk of pancreatic cancer. Ashkenazi Jewish (AJ) individuals carry increased risk for pancreatic cancer and other cancer types.

Methods: We examined the association between family history of cancer, AJ heritage, and incident pancreatic cancer in 49 410 male participants of the prospective Health Professionals Follow-up Study. Read More

Acta Oncol 2019 Mar 12:1-8. Epub 2019 Mar 12.

a National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology , Division of Cancer Medicine, Oslo University Hospital , Oslo , Norway.

Background: Rehabilitation aims to improve function, but the effects of different programs are not clear. The aims of the present study were to: (1) compare the level of fatigue and health-related quality of life (HRQOL) of cancer survivors admitted to a one-week inpatient educational program (IEP) to the general population (NORMS), (2) examine changes in fatigue, HRQOL and physical activity after the IEP and (3) examine the proportions of survivors for female and male separately with clinically relevant improvement (>10% of maximum scale).

Methods: Cancer survivors ≥18 years, diagnosed with breast-, prostate- or gastrointestinal cancer within the last 10 years, about to attend a one-week IEP were invited to an observational study with a pre-post design. Read More

Niger Postgrad Med J 2019 Jan-Mar;26(1):45-52

Department of Medicine, College of Medicine, University of Lagos, Lagos, Nigeria.

Introduction: Identifying the demographic characteristics and causes of death in persons 'brought-in-dead' (BID) will inform possible strategies for the prevention of their occurrence.

Objective: To characterise the demography as well as document the autopsy-determined underlying and immediate causes of death in BID cases presenting to the emergency department (ED) of a tertiary health facility.

Methods: This is a 5-year retrospective descriptive study of 253 autopsied-BID cases. Read More

Medicine (Baltimore) 2019 Mar;98(10):e14774

Department of Surgery, Yokohama City University School of Medicine, Yokohama City, Kanagawa, Japan.

Some patients with differentiated thyroid cancer (DTC) may require an initial low dose (LD) of lenvatinib. However, few studies have investigated the efficacy of LD lenvatinib. We compared the efficacy and tolerability of lenvatinib at an initial LD to those of the standard initial dose of 24 mg in patients with DTC. Read More

Pharm Res 2019 Mar 8;36(4):62. Epub 2019 Mar 8.

Nano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, 6734667149, Iran.

Purpose: The aim of this study is to show a new mesomicroscopic insight into Letrozole (LTZ) loaded nanocomplexes and their ex vivo characteristics as a drug delivery system.

Methods: The LTZ loaded hybrid chitosan-based carrier was fabricated using a modified ionic crosslinking technique and characterized in more detail. To understand the mechanism of LTZ action encapsulated in the hybrid polymer-lipid carrier, all-atom molecular dynamics simulations were also used. Read More

Cancer Genomics Proteomics 2019 Mar-Apr;16(2):129-137

Department of Basic Medical Sciences, Laboratory of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece

Background: To date, the elucidation of serum protein alterations in male breast cancer (MBC) has not been extensively studied, due to the rarity of the disease.

Materials And Methods: In the present work, two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) were employed to detect differences in serum protein expression between patients with MBC and healthy controls.

Results: A panel of differentially expressed serum proteins was identified, including proteins involved in the regulation of the cell cycle [e. Read More