30,372 results match your criteria Breast Cancer Evaluation


Does every woman presenting with malignant calcifications require a post lumpectomy mammogram?

Breast Cancer Res Treat 2019 Apr 20. Epub 2019 Apr 20.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, New York, NY, 10065, USA.

Purpose: Successful breast-conserving surgery (BCS) followed by radiation therapy (XRT) is dependent on complete removal of the cancer with clear surgical margins, providing survival rates equivalent to those observed following mastectomy. In patients who have cancers presenting with microcalcifications, post lumpectomy mammograms (PLM) prior to radiation (XRT) can be performed to ensure that no cancer has been left behind. The purpose of this study was to assess the benefit of PLM in patients with malignant breast tumors presenting with microcalcifications. Read More

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http://dx.doi.org/10.1007/s10549-019-05246-4DOI Listing

Potential risk factors of ovarian cancer and analysis of CA125, a biomarker used for its monitoring and diagnosis.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

School of Life and Environmental Sciences, University of Sydney, Sydney, Australia.

Ovarian cancer (OC) is the fourth most common cancer among Pakistani, Scottish and Chinese women. The aim of the present study was to determine the association of potential risk factors with OC and analysis of Cancer Antigen 125 (CA125) in its monitoring and diagnosis. A total of 200 patients diagnosed with OC were included in this study. Read More

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http://dx.doi.org/10.1007/s11033-019-04794-8DOI Listing

DT-13 suppresses breast cancer metastasis by modulating PLOD2 in the adipocytes microenvironment.

Phytomedicine 2018 Dec 2;59:152778. Epub 2018 Dec 2.

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, China. Electronic address:

Background: Metastasis is the main cause of death in breast cancer and previous researches have indicated the pivotal role of adipocytes in breast cancer metastasis. DT-13, the saponin monomer 13 of the Dwarf lilyturf tuber, has been proved to exert potential anti-metastatic effect, the detailed mechanisms have not been well elucidated and the role of DT-13 in modulating adipocyte-breast cancer microenvironment has been given little attention.

Purpose: This study aims to explore the mechanisms of DT-13 in inhibiting breast cancer metastasis and whether DT-13 inhibit breast cancer metastasis via modulating the interactions between adipocytes and breast cancer cells. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.12.001DOI Listing
December 2018

Hyaluronic acid - dihydroartemisinin conjugate: Synthesis, characterization and in vitro evaluation in lung cancer cells.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Product Development Cell-II, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address:

In recent years, a great deal of attention has been given towards re-purposing and re-innovating the potential drugs. In this regard, dihydroartemisinin (DHA) has been reported to demonstrate anti-proliferative effects on various cancerous cells viz. breast, liver and lung. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.124DOI Listing

In silico markers: an evolutionary and statistical approach to select informative genes of human breast cancer subtypes.

Genes Genomics 2019 Apr 19. Epub 2019 Apr 19.

Department of Informatics, University of Evora, 7004-516, Evora, Portugal.

Background: Recent advancement in bioinformatics offers the ability to identify informative genes from high dimensional gene expression data. Selection of informative genes from these large datasets has emerged as an issue of major concern among researchers.

Objective: Gene functionality and regulatory mechanisms can be understood through the analysis of these gene expression data. Read More

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http://dx.doi.org/10.1007/s13258-019-00816-8DOI Listing

Association of Peritumoral Radiomics With Tumor Biology and Pathologic Response to Preoperative Targeted Therapy for HER2 (ERBB2)-Positive Breast Cancer.

JAMA Netw Open 2019 Apr 5;2(4):e192561. Epub 2019 Apr 5.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

Importance: There has been significant recent interest in understanding the utility of quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic response. No clinically accepted biomarkers are as yet available for estimation of response to human epidermal growth factor receptor 2 (currently known as ERBB2, but referred to as HER2 in this study)-targeted therapy in breast cancer.

Objective: To determine whether imaging signatures on clinical breast magnetic resonance imaging (MRI) could noninvasively characterize HER2-positive tumor biological factors and estimate response to HER2-targeted neoadjuvant therapy. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2561DOI Listing

Preparation and Evaluation of Liposomes Co-Loaded with Doxorubicin, Phospholipase D Inhibitor 5-Fluoro-2-Indolyl Deschlorohalopemide (FIPI) and D-Alpha Tocopheryl Acid Succinate (α-TOS) for Anti-Metastasis.

Nanoscale Res Lett 2019 Apr 18;14(1):138. Epub 2019 Apr 18.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China.

Tumor metastasis has become a key obstacle to cancer treatment, which causes high mortality. Nowadays, it involves multiple complex pathways, and conventional treatments are not effective due to fewer targets. The aims of the present study were to construct a novel liposome delivery system co-loading a specific PLD inhibitor 5-fluoro-2-indolyldes-chlorohalopemide (FIPI) in combination with antitumor drug doxorubicin (DOX) and functional excipient D-alpha tocopheryl acid succinate (α-TOS) for anti-metastasis. Read More

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http://dx.doi.org/10.1186/s11671-019-2964-4DOI Listing

[Contrast agent-free breast MRI : Advantages and potential disadvantages].

Radiologe 2019 Apr 18. Epub 2019 Apr 18.

Universitätsklinik für Radiologie und Nuklearmedizin, Allgemeine und Kinderradiologie, Allgemeines Krankenhaus, Medizinischen Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Background: Contrast-enhanced breast magnetic resonance imaging (MRI) is the most sensitive method for detection of breast cancer. The further spread of breast MRI is limited by the complicated examination procedure and the need for intravenously administered contrast media.

Objectives: Can diffusion-weighted imaging (DWI) replace contrast-enhanced sequences to achieve an unenhanced breast MRI examination?

Materials And Methods: Narrative review and meta-analytic assessment of previously published studies. Read More

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http://link.springer.com/10.1007/s00117-019-0524-7
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http://dx.doi.org/10.1007/s00117-019-0524-7DOI Listing
April 2019
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Comparison of MRI and US in Tumor Size Evaluation of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.

Eur J Breast Health 2019 Apr 1;15(2):119-124. Epub 2019 Apr 1.

Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey.

Objective: Magnetic resonance imaging (MRI) and ultrasonography (US) are commonly used in the pre-surgery determination of tumor size and the follow-up of breast cancer patients treated with neoadjuvant chemotherapy (NAC). The aim of this study was to compare the efficiency of preoperative MRI and US in tumor size evaluation of patients with breast cancer after NAC to guide clinicians on the appropriate treatment plan.

Materials And Methods: The study included a total of 75 patients who had undergone radiological follow-up, surgical treatment and pathological examination in our hospital between 2013 and 2016. Read More

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http://dx.doi.org/10.5152/ejbh.2019.4547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456278PMC

Evaluation of Illness Perception of Women with Breast Cancer in Turkey.

Eur J Breast Health 2019 Apr 1;15(2):98-104. Epub 2019 Apr 1.

Atatürk University School of Nursing, Erzurum, Turkey.

Objective: The aim of this study is to examine the illness perceptions of women with breast cancer and possible relationships between these perceptions and descriptive characteristics such as sociodemographic and clinical characteristics in Turkey.

Materials And Methods: The study was conducted in compliance with correlational, descriptive research principles. Three hundred eighty women with breast cancer who were treated in various hospitals in seven regions of the country were included in the study. Read More

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http://www.eurjbreasthealth.com/eng/makale/684/59/Full-Text
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http://dx.doi.org/10.5152/ejbh.2019.4317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456280PMC
April 2019
1 Read

NAV-KIDS trial: protocol for a multi-centre, staggered randomised controlled trial of a patient navigator intervention in children with chronic kidney disease.

BMC Nephrol 2019 Apr 18;20(1):134. Epub 2019 Apr 18.

Centre for Kidney Research at The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Background: Chronic kidney disease (CKD) is a devastating illness associated with increased mortality, reduced quality of life, impaired growth, neurocognitive impairment and psychosocial maladjustment in children. There is growing evidence of socioeconomic disparities in health outcomes among children with CKD. Patient navigators are trained non-medical personnel who assist patients with chronic conditions journey through the continuum of care and transit across different care settings. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1325-yDOI Listing
April 2019
2 Reads

Synthesis and biological evaluation of purine-pyrazole hybrids incorporating thiazole, thiazolidinone or rhodanine moiety as 15-LOX inhibitors endowed with anticancer and antioxidant potential.

Bioorg Chem 2019 Apr 1;87:821-837. Epub 2019 Apr 1.

Genetic Engineering and Biotechnology Research Institute (GEBRI), City for Scientific Research and Technology, Alexandria, Egypt.

Novel purine-pyrazole hybrids combining thiazoles, thiazolidinones and rhodanines, were designed and tested as 15-LOX inhibitors, potential anticancer and antioxidant agents. All tested compounds were found to be potent 15-LOX inhibitors with IC ranging from 1.76 to 6. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.076DOI Listing
April 2019
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Study of Knowledge, Attitudes, and Practices Toward Risk Factors and Early Detection of Noncommunicable Diseases Among Rural Women in India.

J Glob Oncol 2019 Apr;5:1-10

3 International Agency for Research on Cancer, Lyon, France.

Purpose: In recognition of the growing burden of noncommunicable diseases (NCDs), including cancer, we assessed the knowledge, attitudes, and practices of rural women in low-resourced countries toward common NCDs and the barriers they face in receiving NCD early detection services.

Patients And Methods: The study was conducted in a rural block of India using the Rapid Assessment and Response Evaluation ethnographic assessment, which included in-depth interviews of key health officials; focus group discussions with women, men, teachers, and health workers from the block; and a knowledge, attitudes, and practices questionnaire survey. The home-based survey was conducted among 1,192 women selected from 50 villages of the block using a two-stage randomization process and stratified to 30- to 44-year and 45- to 60-year age-groups. Read More

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http://dx.doi.org/10.1200/JGO.18.00181DOI Listing
April 2019
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Systematic review of economic evaluations of exercise and physiotherapy for patients treated for breast cancer.

Breast Cancer Res Treat 2019 Apr 17. Epub 2019 Apr 17.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK.

Purpose: Treatments for breast cancer can lead to chronic musculoskeletal problems. This study aimed to systematically review the evidence surrounding the cost-effectiveness of exercise and physiotherapy interventions aimed at reducing the risk of physical symptoms and functional limitations due to breast cancer treatment.

Methods: A systematic review of the cost-effectiveness of exercise and physiotherapy interventions during and following treatment for breast cancer was undertaken according to PRISMA guidelines. Read More

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http://dx.doi.org/10.1007/s10549-019-05235-7DOI Listing
April 2019
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First-of-its-kind STARD Inhibitor: Identification and Biological Evaluation as Anticancer Agent.

ACS Med Chem Lett 2019 Apr 20;10(4):475-480. Epub 2019 Feb 20.

Department of Translational Research, Pathology Unit, National Cancer Institute-CRO-IRCSS, 33081 Aviano, Italy.

STARD3 is a cellular protein that represents an attractive target for cancer therapy, being overexpressed in breast cancer and implied in the development of colorectal, gastric, and prostate cancers. Unfortunately, no STARD3 inhibitor has been identified yet. In this work, an strategy was applied to predict a reliable binding mode of cholesterol into STARD3 and to develop a pharmacophore-based virtual screening protocol that allowed the identification of the first STARD3 inhibitor ever reported. Read More

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.8b00509
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http://dx.doi.org/10.1021/acsmedchemlett.8b00509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466518PMC
April 2019
2 Reads

Recent advances in carbohydrate-based cancer vaccines.

Biotechnol Lett 2019 Apr 16. Epub 2019 Apr 16.

Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital (People's Hospital of Hangzhou Medical College), Hangzhou, 310014, Zhejiang, People's Republic of China.

Cancer is a complex multifactorial disease for which many promising therapeutic strategies such as immunotherapy are emerging. Malignant cells frequently express aberrant cell surface carbohydrates, which differentiate them from normal "healthy" cells. This characteristic presents a window for the development of synthetic carbohydrate antigen-based cancer vaccines which can be recognized by the immune system and can bring about T cell-dependent immune responses. Read More

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http://dx.doi.org/10.1007/s10529-019-02675-5DOI Listing
April 2019
2 Reads

Evaluation of a Retroglandular Oncoplastic Technique as a Standard Level I Oncoplastic Breast-Conserving Surgery: A Retrospective Clinicopathologic Study of 102 Patients With Breast Cancer.

Clin Breast Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Breast and Sarcoma Surgery, National Institute of Oncology, Budapest, Hungary. Electronic address:

Background: This study presents a novel Level I oncoplastic breast-conserving surgery technique for performing tumorectomy by retroglandular exploration through a skin incision made in the inferior mammary fold.

Patients And Methods: A retrospective single-center cohort study involving patients with early-stage breast cancer (n = 102) was performed. The patient characteristics were recorded, as well as the quality of life rated by BREAST-Q. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.02.005DOI Listing
February 2019

Lipopolysaccharide-binding protein is an early biomarker of cardiac function after radiotherapy for breast cancer.

Int J Radiat Oncol Biol Phys 2019 Apr 13. Epub 2019 Apr 13.

Department of Biostatistics and Translational Medicine, Medical University of Lodz, Poland; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Purpose: To evaluate the prognostic potential of lipopolysaccharide-binding protein (LBP) levels after breast cancer radiotherapy (RT) for incipient cardiac dysfunction.

Methods And Materials: In this single-centered study, we prospectively enrolled female patients treated for left breast cancer. Healthy age- and sex-matched participants were recruited as controls. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.04.002DOI Listing
April 2019
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Common Breast Problems.

Am Fam Physician 2019 Apr;99(8):505-514

Thomas Jefferson University, Philadelphia, PA, USA.

Palpable breast masses, mastalgia, and nipple discharge are commonly encountered symptoms in outpatient practice, causing significant patient anxiety and precipitating medical consultation. The initial workup includes a detailed clinical history and physical examination. Women presenting with a breast mass will require imaging and further assessment to exclude cancer. Read More

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April 2019
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Neoadjuvant Chemotherapy in Non-Metastatic Breast Cancer- A Study on Practice Trends in a Regional Cancer Treatment Service.

Intern Med J 2019 Apr 16. Epub 2019 Apr 16.

Medical Oncology, Palmerston North Hospital, New Zealand.

Aims: Neoadjuvant Chemotherapy (NACT) is increasingly used for managing locally advanced and high risk non-metastatic breast cancer(NMBC). The goal of this study is to describe trends in NACT use, assess compliance to best practice recommendations and determine treatment response rates in a regional cancer treatment service.

Method: In this retrospective cross- sectional study, electronic records of patients who underwent NACT in centres covered by the Midcentral Regional Cancer Treatment Service (RCTS) in 2013 and 2017 were reviewed. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14326
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http://dx.doi.org/10.1111/imj.14326DOI Listing
April 2019
2 Reads

Evaluation of the response of breast cancer patients to neoadjuvant chemotherapy by combined contrast-enhanced ultrasonography and ultrasound elastography.

Exp Ther Med 2019 May 6;17(5):3655-3663. Epub 2019 Mar 6.

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

The purpose of the present study was to investigate whether contrast-enhanced ultrasonography (CEUS) in combination with ultrasound elastography (UE) is able to accurately predict the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients. A total of 65 breast cancer patients who received NAC at the First Affiliated Hospital of Zhejiang University (Hangzhou, China) between February 2016 and August 2017 and were recruited for the present study. Prior to and after NAC, examination by CEUS, UE or their combination was performed. Read More

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http://dx.doi.org/10.3892/etm.2019.7353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447770PMC
May 2019
1 Read

Effectiveness, safety, and economic evaluation of topical application of a herbal ointment, Jaungo, for radiation dermatitis after breast conserving surgery in patients with breast cancer (GREEN study): Study protocol for a randomized controlled trial.

Medicine (Baltimore) 2019 Apr;98(15):e15174

Associate Professor, Department of Korean Obstetrics and Gynecology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, Republic of Korea.

Introduction: This is a prospective, open-label, parallel-group, randomized controlled trial that evaluates the effectiveness and safety of adjuvant application of Jaungo (JUG) for radiation-induced dermatitis (RD) in breast cancer patients undergoing radiation therapy, in comparison with general supportive care (GSC).

Methods/design: Eighty female patients, who have been diagnosed with unilateral breast cancer, will be allocated to either the JUG or GSC group with an allocation ratio of 1:1 after breast conservation surgery, in the Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea. Both the groups will be subjected to GSC, but only the JUG group participants will apply adjuvant JUG ointment on the irradiated skin for 6 weeks, twice a day. Read More

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http://dx.doi.org/10.1097/MD.0000000000015174DOI Listing
April 2019
3 Reads

Strain histograms used for differential diagnosis of breast masses according to hardness percentage.

Medicine (Baltimore) 2019 Apr;98(15):e15125

Department of Special Diagnosis.

To evaluate the diagnostic performance of percentage of hard component (PHC) versus strain ratio (SR) in focal breast lesion diagnosis.Ultrasonography and elastography images of 245 malignant and 255 benign breast lesions were obtained and analyzed according to the Breast Imaging-Reporting and Data System of the American College of Radiology. PHC and SR were measured for each lesion and receiver operating characteristic (ROC) curve analysis was performed to evaluate and compare the diagnostic performance of conventional ultrasound (CU) only, PHC with CU, and SR with CU. Read More

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http://dx.doi.org/10.1097/MD.0000000000015125DOI Listing
April 2019
1 Read

Assessment of Terahertz Imaging for Excised Breast Cancer Tumors with Image Morphing.

J Infrared Millim Terahertz Waves 2018 Dec 9;39(12):1283-1302. Epub 2018 Aug 9.

University of Arkansas, Fayetteville, AR 72701 USA,

This paper presents an image morphing algorithm for quantitative evaluation methodology of terahertz (THz) images of excised breast cancer tumors. Most current studies on the assessment of THz imaging rely on qualitative evaluation, and there is no established benchmark or procedure to quantify the THz imaging performance. The proposed morphing algorithm provides a tool to quantitatively align the THz image with the histopathology image. Read More

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http://dx.doi.org/10.1007/s10762-018-0529-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457662PMC
December 2018

Near-infrared image-guided laparoscopic omental flap for breast cancer.

Asian J Endosc Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

Background: Near-infrared (NIR) imaging with indocyanine green (ICG)-enhanced fluorescence is widely used in laparoscopic surgery. This study aimed to evaluate this technique's feasibility and usefulness in intraoperatively assessing vascular perfusion in a laparoscopically harvested omental flap.

Materials And Surgical Techniques: From March 2015 to February 2016, we prospectively evaluated patients undergoing breast cancer surgery followed by immediate breast reconstruction using a laparoscopically harvested omental flap. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ases.12709
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http://dx.doi.org/10.1111/ases.12709DOI Listing
April 2019
3 Reads

Shed HER2 surrogacy evaluation in primary breast cancer patients: a study assessing tumor tissue HER2 expression at both extracellular and intracellular levels.

Scand J Clin Lab Invest 2019 Apr 15:1-8. Epub 2019 Apr 15.

a Regional Center for Biomarkers, Department of Clinical Pathology and Transfusion Medicine , Azienda ULSS 3 Serenissima, Regional Hospital , Venice , Italy.

The aim of the present study was to investigate serum HER2 extracellular domain (ECD) as a putative surrogate marker of the shedding phenomenon of HER2 receptor from the tumor tissue of primary breast cancer (BC) patients. A pilot retrospective study was conducted on 100 matched serum and tissue samples from patients with node-positive primary BC, stage II/III. Analysis of association and concordance between serum HER2 ECD levels (measured by chemiluminescence immunoassay) and the expression in matched tumor tissue of HER2 ECD and intracellular receptor domain (ICD) (determined by immunohistochemistry) were performed. Read More

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http://dx.doi.org/10.1080/00365513.2019.1600200DOI Listing
April 2019
2 Reads

[Preoperative evaluation of sentinel lymph node biopsy using contrast-enhanced ultrasonography in early breast cancer patients and the involved disturbing factors].

Zhonghua Yi Xue Za Zhi 2019 Apr;99(14):1086-1089

Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital), Zhengzhou 450008, China.

To explore the preoperative evaluation of sentinel lymph node (SLN) biopsy using contrast-enhanced ultrasonography (CEUS) in early breast cancer patients and the involved disturbing factors. Eighty-three female early breast cancer patients who underwent concurrent surgery in the Affiliated Cancer Hospital of Zhengzhou University between January 2017 and May 2018 were enrolled. CEUS was used to seek SLN and determine lymph node metastasis after signature of preoperative informed consent. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.14.010DOI Listing
April 2019
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Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases.

Breast Cancer Res Treat 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiation Oncology, Dana-Farber Cancer Institute/Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Purpose: Brain metastases from breast cancer are frequently managed with brain-directed radiation but the impact of subtype on intracranial recurrence patterns after radiation has not been well-described. We investigated intracranial recurrence patterns of brain metastases from breast cancer after brain-directed radiation to facilitate subtype-specific management paradigms.

Methods: We retrospectively analyzed 349 patients with newly diagnosed brain metastases from breast cancer treated with brain-directed radiation at Brigham and Women's Hospital/Dana-Farber Cancer Institute between 2000 and 2015. Read More

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http://link.springer.com/10.1007/s10549-019-05236-6
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http://dx.doi.org/10.1007/s10549-019-05236-6DOI Listing
April 2019
3 Reads

A novel biomarker, active whole skeletal total lesion glycolysis (WS-TLG), as a quantitative method to measure bone metastatic activity in breast cancer patients.

Ann Nucl Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Nuclear Medicine, Cancer Institute Hospital, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8555, Japan.

Objective: There is no good response evaluation method for skeletal metastasis. We aimed to develop a novel quantitative method to evaluate the response of skeletal metastasis, especially lytic lesions, for treatment.

Methods: A method to measure active bone metastatic burden quantitatively using F-18 fluorodeoxyglucose positron emission tomography with computed tomography (FDG-PET/CT) in breast cancer patients, whole skeletal total lesion glycolysis (WS-TLG), a summation of each skeletal lesion's TLG, was developed. Read More

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http://dx.doi.org/10.1007/s12149-019-01359-4DOI Listing
April 2019
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Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and in vitro evaluation in 2D/3D in vitro models.

J Control Release 2019 Apr 11. Epub 2019 Apr 11.

Functional Polymer Materials, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, Würzburg University, Röntgenring 11, 97070 Würzburg, Germany. Electronic address:

Curcumin (CUR) is a natural extract from the plant Curcuma longa and part of turmeric, a spice and herbal remedy in traditional medicine. Thousands of papers claim a plethora of health benefits by CUR, but a growing number of reports and contributions caution that many experimental data may be artifacts or outright deny any suitability of CUR due to its problematic physicochemical properties. Two major issues often encountered with CUR are its extraordinarily low solubility in water and its limited chemical stability. Read More

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http://dx.doi.org/10.1016/j.jconrel.2019.04.014DOI Listing

Evaluation of angularly condensed diquinothiazines as potential anticancer agents.

Bioorg Chem 2019 Apr 6;87:810-820. Epub 2019 Apr 6.

The Medical University of Silesia, School of Pharmacy with the Division of Laboratory Medicine, Department of Cell Biology, Jedności 8, 41-200 Sosnowiec, Poland.

We present efficient synthesis of isomeric types of angularly fused diquinothiazines in the reactions of 2,2'-dichloro-3,3'-diquinolinyl disulfide and diquinodithiin with 3-, 5-, 6- and 8-aminoquinolines. The pentacyclic diquinothiazine ring systems were identified as diquino[3,2-b;3',4'-e][1,4]thiazine, diquino[3,2-b;5',6'-e][1,4]thiazine, diquino[3,2-b;6',5'-e][1,4]thiazine and diquino[3,2-b;8',7'-e][1,4]thiazine with advanced two-dimensional H and C NMR techniques (COSY, ROESY, HSQC and HMBC) of N-methyl derivatives. The identification of pentacyclic ring system was confirmed by X-ray diffraction analysis of selected N-alkyl derivatives. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.04.005DOI Listing

Preliminary phytochemical analysis and evaluation of the antioxidant and anti-proliferative effects of Plinia peruviana leaves: an in vitro approach.

Nat Prod Res 2019 Apr 12:1-9. Epub 2019 Apr 12.

a Pharmaceutical Sciences , Federal University of Santa Maria , Santa Maria , Rio Grande do Sul State , Brazil.

Plinia peruviana (Poir.) Govaerts (Myrtaceae) occurs from Pará to Rio Grande do Sul states, Brazil. The leaf extract of this species was investigated. Read More

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http://dx.doi.org/10.1080/14786419.2019.1602827DOI Listing
April 2019
1 Read

Photoacoustic imaging for the evaluation of early tumor response to antivascular treatment.

Quant Imaging Med Surg 2019 Feb;9(2):160-170

Department of Medical Imaging, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

Background: Photoacoustic imaging (PAI) provides real-time noninvasive and contrast agent-free monitoring of the concentrations of some endogenous compounds related to tumor vascularization and oxygenation. In this study, we used PAI to noninvasively evaluate tumor responses to antiangiogenic therapy.

Methods: In vivo studies were performed with the approval of our institutional animal ethics committee. Read More

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http://dx.doi.org/10.21037/qims.2018.11.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414773PMC
February 2019
1 Read

Cost-Effectiveness Analysis of Pertuzumab With Trastuzumab and Chemotherapy Compared to Trastuzumab and Chemotherapy in the Adjuvant Treatment of HER2-Positive Breast Cancer in the United States.

Value Health 2019 Apr 11;22(4):408-415. Epub 2019 Mar 11.

Genentech, Inc., South San Francisco, USA.

Objective: The APHINITY trial assessed the effectiveness and the safety of adding pertuzumab to trastuzumab and chemotherapy (THP) compared to trastuzumab and chemotherapy (TH) in the adjuvant management of human epidermal growth factor 2-positive (HER2+) breast cancer. We performed a study to project the potential cost-effectiveness of THP vs. TH. Read More

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http://dx.doi.org/10.1016/j.jval.2018.11.014DOI Listing
April 2019
2 Reads

Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms.

J Hematol Oncol 2019 Apr 11;12(1):38. Epub 2019 Apr 11.

Shahid Akbar Abadi Clinical Research Development Unit (ShCRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.

Breast cancer is the most common malignancy in women all over the world. Genetic background of women contributes to her risk of having breast cancer. Certain inherited DNA mutations can dramatically increase the risk of developing certain cancers and are responsible for many of the cancers that run in some families. Read More

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http://dx.doi.org/10.1186/s13045-019-0725-6DOI Listing

The impact of radiodermatitis on breast cancer patients' quality of life during treatment: a prospective cohort study.

J Pain Symptom Manage 2019 Apr 8. Epub 2019 Apr 8.

Graduate Program in Health Science, Medical School, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil. Av. Pará, 1720, Block 2H, room 9. Campus Umuarama. CEP 38.405-320. Uberlandia - MG. Electronic address:

Context: In the oncology field, quality of life (QoL) is recognized as an essential component. However few studies have evaluated radiotherapy (RT) and its adverse events, specifically radiodermatitis.

Objectives: To investigate the influence of radiodermatitis severity on QoL of women with breast cancer (BC) throughout RT. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.03.017DOI Listing
April 2019
6 Reads

Current Landscape of Immunotherapy in Breast Cancer: A Review.

JAMA Oncol 2019 Apr 11. Epub 2019 Apr 11.

Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts.

Importance: There is tremendous interest in using immunotherapy to treat breast cancer, as evidenced by the more than 290 clinical trials ongoing at the time of this narrative review. The objective of this review is to describe the current status of immunotherapy in breast cancer, highlighting its potential in both early-stage and metastatic disease.

Observations: After searching ClinicalTrials. Read More

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2018.7147DOI Listing
April 2019
19 Reads

Feasibility of Masood's cytological index for screening breast lesions in low resource setting.

Breast J 2019 Apr 10. Epub 2019 Apr 10.

Department of Pathology, Dayanand Medical College & Hospital, Ludhiana, India.

Fine needle aspiration cytology has long been an accepted diagnostic modality in combination with physical examination and mammography to investigate breast lesions. In the present era, more proficient methods such as stereotactic mammographically guided breast biopsy is the preferred choice, however, in low resource setting, FNAC still remains the most cost effective and sampling modality to diagnose breast cancer. With the intention to evaluate the efficacy and limitations of FNAC in evaluation of breast lesions in low resource setting, we employed the Masood's cytological staging system to stratify the breast lesions and correlate them with histopathology wherever possible. Read More

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http://dx.doi.org/10.1111/tbj.13239DOI Listing
April 2019
5 Reads

Development of an exercise adherence program for breast cancer survivors with cancer-related fatigue-an intervention mapping approach.

Support Care Cancer 2019 Apr 10. Epub 2019 Apr 10.

College of Nursing, Yonsei University, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, South Korea.

Purpose: Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors (BCS), with severe impact on quality of life. CRF can be reduced through exercise, but conversely, is also a barrier to exercising. The aim of this article was to apply the intervention mapping protocol (IMP) to develop an exercise adherence intervention for BCS with CRF. Read More

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http://dx.doi.org/10.1007/s00520-019-04785-2DOI Listing
April 2019
2 Reads

Guidelines for using sigQC for systematic evaluation of gene signatures.

Nat Protoc 2019 Apr 10. Epub 2019 Apr 10.

Computational Biology and Integrative Genomics Lab, MRC/CRUK Oxford Institute and Department of Oncology, University of Oxford, Oxford, UK.

With the increased use of next-generation sequencing generating large amounts of genomic data, gene expression signatures are becoming critically important tools for the interpretation of these data, and are poised to have a substantial effect on diagnosis, management, and prognosis for a number of diseases. It is becoming crucial to establish whether the expression patterns and statistical properties of sets of genes, or gene signatures, are conserved across independent datasets. Conversely, it is necessary to compare established signatures on the same dataset to better understand how they capture different clinical or biological characteristics. Read More

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http://www.nature.com/articles/s41596-019-0136-8
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http://dx.doi.org/10.1038/s41596-019-0136-8DOI Listing
April 2019
5 Reads

Evaluation of lymph node ratio and morphologic patterns of nodal reactive hyperplasia in primary organ malignancy.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):216-221

Department of Pathology, T.N Medical College and B.Y.L Nair Hospital, Mumbai, Maharashtra, India.

Background: Lymph node ratio (LNR) in cancer staging is the ratio of nodal metastases (LNM) to total nodes harvested (LNH). Reactive nodal hyperplasia can exhibit morphological patterns I to VI.

Aims: To measure LNR and evaluate it with tumor stage, tumor grade, LN reactive patterns, and LN size. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_62_18DOI Listing
April 2019
1 Read

[Preoperative evaluation of histologic grade in invasive breast cancer with T2W-MRI based radiomics signature].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):285-289

Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515; Department of Radiology, Guangdong Provincial People's Hospital, Guangzhou 510080, China.

Objective: To develop and validate a fat-suppressed (T2 weighted-magnetic resonance imaging, T2W-MRI) based radiomics signature to preoperatively evaluate the histologic grade (grade I/II VS. grade III) of invasive breast cancer.
 Methods: A total of 202 patients with MRI examination and pathologically confirmed invasive breast cancer from June 2011 to February 2017 were retrospectively enrolled. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2019.03.009DOI Listing
March 2019
2 Reads

Methodological quality of clinical practice guidelines with physical activity recommendations for people diagnosed with cancer: A systematic critical appraisal using the AGREE II tool.

PLoS One 2019 10;14(4):e0214846. Epub 2019 Apr 10.

School of Rehabilitation Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.

Evidence suggests physical activity (PA) is beneficial for people diagnosed with cancer. Clinical practice guidelines provide specific recommendations based on available research and are useful in informing evidence-based practice and guiding future research. Little is known on the extent and quality of guidelines on PA targeted to the cancer population. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214846PLOS
April 2019
3 Reads
3.234 Impact Factor

Systematic evaluation of cancer-specific genetic risk score for 11 types of cancer in The Cancer Genome Atlas and Electronic Medical Records and Genomics cohorts.

Cancer Med 2019 Apr 9. Epub 2019 Apr 9.

Program for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, Illinois.

Background: Genetic risk score (GRS) is an odds ratio (OR)-weighted and population-standardized method for measuring cumulative effect of multiple risk-associated single nucleotide polymorphisms (SNPs). We hypothesize that GRS is a valid tool for risk assessment of most common cancers.

Methods: Utilizing genotype and phenotype data from The Cancer Genome Atlas (TCGA) and Electronic Medical Records and Genomics (eMERGE), we tested 11 cancer-specific GRSs (bladder, breast, colorectal, glioma, lung, melanoma, ovarian, pancreatic, prostate, renal, and thyroid cancer) for association with the respective cancer type. Read More

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http://dx.doi.org/10.1002/cam4.2143DOI Listing
April 2019
1 Read

Health care services use among long-term breast cancer survivors: a systematic review.

J Cancer Surviv 2019 Apr 9. Epub 2019 Apr 9.

Department of Epidemiology and Evaluation, IMIM (Hospital del Mar Medical Research Institute), Passeig Marítim, 25-29, 08003, Barcelona, Spain.

Purpose: Long-term breast cancer survivors are women surviving at least 5 years after diagnosis. This systematic review aimed to summarize the main characteristics and patterns of healthcare service use (frequency of visits, health providers visited, and preventive care performed) among long-term breast cancer survivors.

Methods: We used standard Cochrane Collaboration methods and searched the MEDLINE and EMBASE databases up to January 2018. Read More

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http://dx.doi.org/10.1007/s11764-019-00755-zDOI Listing
April 2019
1 Read

Comparison of tumor‑targeting properties of directly and indirectly radioiodinated designed ankyrin repeat protein (DARPin) G3 variants for molecular imaging of HER2.

Int J Oncol 2019 Feb 11. Epub 2019 Feb 11.

Department of Immunology, Genetics and Pathology, Uppsala University, SE 75185 Uppsala, Sweden.

Evaluation of human epidermal growth factor receptor 2 (HER2) expression levels in breast and gastroesophageal cancer is used for the stratification of patients for HER2‑targeting therapies. The use of radionuclide molecular imaging may facilitate such evaluation in a non‑invasive way. Designed ankyrin repeat proteins (DARPins) are engineered scaffold proteins with high potential as probes for radionuclide molecular imaging. Read More

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http://dx.doi.org/10.3892/ijo.2019.4712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411343PMC
February 2019
2 Reads
3.025 Impact Factor

Evaluation of the Radiosensitizing Potency of Bromelain for Radiation Therapy of 4T1 Breast Cancer Cells.

J Med Signals Sens 2019 Jan-Mar;9(1):68-74

Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Breast cancer (BC) remains the leading cause of death in women worldwide, despite the improvements of cancer screening and treatment methods. Recently, development of novel anticancer drugs for the improved prevention and treatment of BC is in the center of research. The anticancer effects of bromelain, as enzyme extract derived from the pineapples, contains chemicals that interfere with the growth of tumor cells. Read More

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http://dx.doi.org/10.4103/jmss.JMSS_25_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419564PMC
April 2019
2 Reads

Immunologic Consequences of Sequencing Cancer Radiotherapy and Surgery.

JCO Clin Cancer Inform 2019 Apr;3:1-16

3 Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Purpose: Early-stage cancers are routinely treated with surgery followed by radiotherapy (SR). Radiotherapy before surgery (RS) has been widely ignored for some cancers. We evaluate overall survival (OS) and disease-free survival (DFS) with SR and RS for different cancer types and simulate the plausibility of RS- and SR-induced antitumor immunity contributing to outcomes. Read More

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http://dx.doi.org/10.1200/CCI.18.00075DOI Listing
April 2019
1 Read

Increased breast cancer risk in women with neurofibromatosis type 1: a meta-analysis and systematic review of the literature.

Hered Cancer Clin Pract 2019 25;17:12. Epub 2019 Mar 25.

1Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210 USA.

Background: Neurofibromatosis type 1 (NF1) is a cancer predisposing syndrome. Studies suggest that women < 50 years old (y.o. Read More

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https://hccpjournal.biomedcentral.com/articles/10.1186/s1305
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http://dx.doi.org/10.1186/s13053-019-0110-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434896PMC
March 2019
6 Reads