37,268 results match your criteria Breast Cancer Evaluation

Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.

Reprod Toxicol 2022 Jun 25. Epub 2022 Jun 25.

Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA. Electronic address:

Work from numerous fields of study suggests that exposures to hormonally active chemicals during sensitive windows of development can alter mammary gland development, function, and disease risk. Stronger links between many environmental pollutants and disruptions to breast health continue to be documented in human populations, and there remain concerns that the methods utilized to identify, characterize, and prioritize these chemicals for risk assessment and risk management purposes are insufficient. There are also concerns that effects on the mammary gland have been largely ignored by regulatory agencies. Read More

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Evaluation of the effect of nitrate and chloride on Cd(II)-induced cell oxidative stress by scanning electrochemical microscopy.

Anal Methods 2022 Jun 28. Epub 2022 Jun 28.

Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry and Biology, Beijing University of Technology, Beijing 100124, P. R. China.

Cadmium (Cd) is one of the most prevalent toxic metal pollutants, which is widely distributed in various environmental media and organisms. Literature studies have documented that Cd could stimulate cellular oxidative stress, and the increased intracellular reactive oxygen species (ROS) might destroy certain proteins and DNA and subsequently lead to cell apoptosis. Although several studies have studied the co-exposure between cadmium and other metals, information on the potential effects of Cd and its counterions is still lacking. Read More

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An Evaluation of Metabolic, Dietetic, and Nutritional Status Reveals Impaired Nutritional Outcomes in Breast Cancer Patients.

Nutr Cancer 2022 Jun 28:1-12. Epub 2022 Jun 28.

Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil.

Nutritional status can change in breast cancer patients after treatment. However, the metabolic implications of those alterations are poorly understood. We used a cross-sectional study design to compare body composition, lipids, glucose levels, and adiposity indices in breast cancer patients with a matched control and a healthy group. Read More

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An evaluation of lymphovascular invasion in relation to biology and prognosis according to subtypes in invasive breast cancer.

Oncol Lett 2022 Aug 7;24(2):245. Epub 2022 Jun 7.

Department of Pathology, Kumamoto Shinto General Hospital, Kumamoto, Kumamoto 862-8655, Japan.

Lymphovascular invasion (LVI) is associated with a poor outcome in breast cancer. The purpose of the present study was to evaluate the clinical significance of LVI in primary breast cancer and to investigate disease-free survival as a prognostic marker according to the breast cancer subtypes. This study examined 4,652 consecutive cases of invasive breast cancer excluding the patients with non-invasive cancer, stage IV and those who underwent neo-adjuvant therapy from February 2002 to February 2021. Read More

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Transdisciplinary Preliminary Evaluation of Goal Maintenance in Cancer-Related Cognitive Impairment.

OTJR (Thorofare N J) 2022 Jun 27:15394492221103150. Epub 2022 Jun 27.

University of Missouri, Columbia, USA.

Women treated for breast cancer often experience decreases in executive functioning, including goal maintenance, which interferes with daily living. The objective of this study was to conduct a preliminary comparison of cognitive neuroscience assessment performance with neuropsychological, self-report, and performance-based assessments of goal maintenance in women with breast cancer. Women treated for breast cancer in the preceding 3 years completed a battery of cognitive assessments. Read More

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Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models.

J Transl Med 2022 Jun 27;20(1):290. Epub 2022 Jun 27.

Department of Breast and Thoracic Oncology, Division of Breast Medical Oncology, Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", 80131, Naples, Italy.

Background: Triple negative breast cancer (TNBC) is an aggressive disease characterized by high risk of relapse and development of resistance to different chemotherapy agents. Several targeted therapies have been investigated in TNBC with modest results in clinical trials. Among these, PI3K/AKT inhibitors have been evaluated in addition to standard therapies, yielding conflicting results and making attempts on elucidating inherent mechanisms of resistance of great interest. Read More

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Mechanisms behind context-dependent role of glucocorticoids in breast cancer progression.

Cancer Metastasis Rev 2022 Jun 27. Epub 2022 Jun 27.

Department of Molecular Genetics and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest, Hungary.

Glucocorticoids (GCs), mostly dexamethasone (dex), are routinely administered as adjuvant therapy to manage side effects in breast cancer. However, recently, it has been revealed that dex triggers different effects and correlates with opposite outcomes depending on the breast cancer molecular subtype. This has raised new concerns regarding the generalized use of GC and suggested that the context-dependent effects of GCs can be taken into potential consideration during treatment design. Read More

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Microfluidic Biosensor-Based Devices for Rapid Diagnosis and Effective Anti-cancer Therapeutic Monitoring for Breast Cancer Metastasis.

Adv Exp Med Biol 2022 ;1379:319-339

Regenerative Medicine and Stem Cell Laboratory (RMS), Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, India.

Breast cancer with unpredictable metastatic recurrence is the leading cause of cancer-related mortality. Early cancer detection and optimized therapy are the principal determining factors for increased survival rate. Worldwide, researchers and clinicians are in search of efficient strategies for the timely management of cancer progression. Read More

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Nipple Discharge Imaging Evaluation with Mammography, Ultrasound, Galactography, and MRI.

Acad Radiol 2022 Jun 24. Epub 2022 Jun 24.

The University of Texas MD Anderson Cancer Center, Department of Breast Imaging, 1515 Holcombe Blvd, Unit 1350, CPB5.3201, Houston, TX 77030.

Rationale And Objective: To determine the diagnostic yield of various imaging tests used to evaluate nipple discharge.

Materials And Methods: A single institution, IRB-approved, retrospective study was performed of 320 consecutive patients presenting with nipple discharge. Imaging and pathology were reviewed to determine the yield for malignancy, atypical high-risk lesions (HRLs), and intraductal papillomas (IDPs). Read More

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New thiophene, thienopyridine and thiazoline-based derivatives: Design, synthesis and biological evaluation as antiproliferative agents and multitargeting kinase inhibitors.

Bioorg Chem 2022 Jun 14;127:105964. Epub 2022 Jun 14.

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. Electronic address:

Multitargeting kinase inhibitors recently proved to be a profitable approach for conquering cancer proliferation. The current study represents the design and synthesis of new thiophene, thienopyridine, and thiazoline-based derivatives 4-14a,b. All the target compounds were examined in vitro against three cancer cell lines; the liver (HepG-2), breast (MCF-7), and colon (HCT-116) where the thiophene-based compounds 5a-c, demonstrated the most potent activity. Read More

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Liver Kinase B1 Regulates Remodeling of the Tumor Microenvironment in Triple-Negative Breast Cancer.

Front Mol Biosci 2022 8;9:847505. Epub 2022 Jun 8.

Department of Biological and Agricultural Engineering, Louisiana State University, Baton Rouge, LA, United States.

Liver kinase B1 (LKB1) is a potent tumor suppressor that regulates cellular energy balance and metabolism as an upstream kinase of the AMP-activated protein kinase (AMPK) pathway. LKB1 regulates cancer cell invasion and metastasis in multiple cancer types, including breast cancer. In this study, we evaluated LKB1's role as a regulator of the tumor microenvironment (TME). Read More

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Molecular Subtypes As Emerging Predictors of Clinicopathological Response to Neoadjuvant Chemotherapy (NACT) in Locally Advanced Breast Cancer (LABC): A Single-Centre Experience in Western India.

Cureus 2022 May 22;14(5):e25229. Epub 2022 May 22.

General Surgery, Dr. Sampurnanand Medical College, Jodhpur, IND.

Introduction: Locally advanced breast cancer (LABC) is a subset of breast cancer characterized by the most advanced breast tumours in the absence of distant metastasis. Treatment of LABC has evolved from a single modality treatment to multimodality management. Neoadjuvant chemotherapy (NACT) is increasingly being used to treat patients with LABC. Read More

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Preoperative evaluation of breast cancer: Contrast-enhanced mammography versus contrast-enhanced magnetic resonance imaging: A systematic review and meta-analysis.

Breast Dis 2022 ;41(1):303-315

Zabol University of Medical Sciences, Zabol, Iran.

Introduction: Breast cancer is the most common cancer in women worldwide. It is responsible for about 23% of cancer in females in both developed and developing countries. This study aimed to compare the diagnostic performance of contrast-enhanced mammography (CEM) and contrast-enhanced magnetic resonance imaging (CEMRI) in preoperative evaluations of breast lesions. Read More

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Update on prognostic and predictive biomarkers of breast cancer.

Semin Diagn Pathol 2022 Jun 18. Epub 2022 Jun 18.

Department of pathology, The Ohio State University Wexner Medical Center, Columbus OH. Electronic address:

Breast cancer represents a heterogeneous group of human cancer at both histological and molecular levels. Estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) are the most commonly used biomarkers in clinical practice for making treatment plans for breast cancer patients by oncologists. Recently, PD-L1 testing plays an important role for immunotherapy for triple-negative breast cancer. Read More

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Imaging biomarkers of breast cancers originating from the major lactiferous ducts: Ductal adenocarcinoma of the breast, DAB.

Eur J Radiol 2022 Jun 4;154:110394. Epub 2022 Jun 4.

School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Wuxing Street, Taipei 110, Taiwan.

Purpose: As we have previously demonstrated, breast cancers originating in the major lactiferous ducts and propagating through the process of neoductgenesis are a distinct subtype of invasive breast cancers, although by current practice they are placed within the group termed ductal carcinoma in situ (DCIS) and are consequently underdiagnosed and undertreated. Imaging biomarkers provide a reliable indication of the site of origin of this breast cancer subtype (Ductal Adenocarcinoma of the breast, DAB) and have excellent concordance with long-term patient outcome. In the present paper, the imaging biomarkers of DAB are described in detail to encourage and facilitate its recognition as a distinct, invasive breast cancer subtype. Read More

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Primary Breast Lymphoma Mimicking Metastatic Breast Cancer on 18F-FDG PET-CT.

J Pak Med Assoc 2022 Jun;72(6):1241-1242

Department of Hematology, Kuwait Cancer Control Center, Kuwait.

18F-Fluorodeoxyglucose (FDG) PET-CT is an excellent imaging modality for the evaluation of non-Hodgkin lymphoma (NHL). We report a case of a 45-year-old woman presented with a large right breast mass and suspicious right axillary lymph nodes referred for 18F-FDG PET-CT for staging. 18F-FDG PET-CT images show large hypermetabolic right breast mass infiltrating the skin, multiple hypermetabolic right axillary and subpectoral lymph nodes, along with multiple hypermetabolic bone lesions at axial and appendicular skeleton. Read More

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Synthesis of novel isoxazole-carboxamide derivatives as promising agents for melanoma and targeted nano-emulgel conjugate for improved cellular permeability.

BMC Chem 2022 Jun 24;16(1):47. Epub 2022 Jun 24.

Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, 00970, Palestine.

Background: Cancer is one of the most dangerous and widespread diseases in the world today and it has risen to the position of the leading cause of death around the globe in the last few decades. Due to the inherent resistance of many types of cancer to conventional radiotherapy and chemotherapy, it is vital to develop innovative anticancer medications. Recently, a strategy based on nanotechnology has been used to improve the effectiveness of both old and new cancer drugs. Read More

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Isolation and characterisation of pharmaceutically versatile molecules from and evaluation of their cytotoxic activity against human cancer cell lines.

Nat Prod Res 2022 Jun 24:1-6. Epub 2022 Jun 24.

Plant Molecular Biology and Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, India.

The disclosed study reveals isolation, characterization and anticancer evaluation of . The extracts and isolated compounds were used for cytotoxic activity against (lung (A549), pancreatic (MIAPaCa), colon (HCT-116), breast (MDA-MB-231) and breast (MDA-MB-468) cell lines. The extracts were screened for cytotoxicity using MTT colorimetric assay. Read More

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Health-related quality of life outcomes after neoadjuvant chemoradiotherapy for rectal cancer in NRG Oncology/NSABP R-04.

Cancer 2022 Jun 24. Epub 2022 Jun 24.

NRG Oncology Statistics and Data Management Center, Pittsburgh, Pennsylvania, USA.

Background: There has been limited evaluation of health-related quality of life (HRQOL) in rectal cancer patients receiving neoadjuvant chemoradiotherapy. HRQOL outcomes in the National Surgical Adjuvant Breast and Bowel Project R-04 trial are examined in this article.

Methods: Between 2004 and 2010, R-04 patients were invited to enroll in the HRQOL substudy, with questionnaires administered before randomization, after completion of chemoradiotherapy, and 1-year after surgery. Read More

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A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scale.

PLoS Comput Biol 2022 Jun 24;18(6):e1009294. Epub 2022 Jun 24.

Centre of Biological Engineering (CEB), Universidade do Minho, Braga, Portugal.

Constraint-based (CB) metabolic models provide a mathematical framework and scaffold for in silico cell metabolism analysis and manipulation. In the past decade, significant efforts have been done to model human metabolism, enabled by the increased availability of multi-omics datasets and curated genome-scale reconstructions, as well as the development of several algorithms for context-specific model (CSM) reconstruction. Although CSM reconstruction has revealed insights on the deregulated metabolism of several pathologies, the process of reconstructing representative models of human tissues still lacks benchmarks and appropriate integrated software frameworks, since many tools required for this process are still disperse across various software platforms, some of which are proprietary. Read More

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Importance of Incidental Findings in Preoperative Computed Tomography Angiography for Abdominal-Based Free Flap Breast Reconstruction: A Multi-institutional Study.

Plast Reconstr Surg 2022 Jun 24. Epub 2022 Jun 24.

Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO.

Background: Besides its intended purpose of perforator mapping, CTA can also identify incidental findings that may require further evaluation. In this multi-institutional study, we evaluated the frequency of incidental findings and their significance and impact on treatment course. We also aimed to identify risk factors for detecting such findings. Read More

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Interventional oncology procedures for breast cancer metastatic disease: current role and clinical applications.

Diagn Interv Radiol 2022 May;28(3):249-256

2nd Department of Radiology, University General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Worldwide, breast cancer constitutes the most common malignant neoplasm among females, impacting 2.1 million women annually. Interventional oncology techniques have been recently added as an additional therapeutic and palliative alternative in breast cancer metastatic disease, concerning mainly osseous, liver, and lung metastasis. Read More

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Magnetic Resonance Imaging Features in Diagnosis of Breast Cancer and Evaluation of Effect of Epidermal Growth Factor Receptor-Targeted Therapy.

Biomed Res Int 2022 14;2022:3127058. Epub 2022 Jun 14.

Department of Oncology, Jincheng People's Hospital, Jincheng, 048000 Shanxi, China.

Breast cancer diagnosis and treatment are important healthcare issues in the Industrialized World. In this study, magnetic resonance imaging (MRI) images are used to diagnose breast cancer (BC) and analyze the application effect of epidermal factor receptor-targeted therapy in the treatment of BC. A total of 858 patients diagnosed with BC in Jincheng People's Hospital from 2019 to 2021 are included and randomly divided into an experimental group and a control group. Read More

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Design and Evaluation of pH Sensitive PEG-Protamine Nanocomplex of Doxorubicin for Treatment of Breast Cancer.

Polymers (Basel) 2022 Jun 14;14(12). Epub 2022 Jun 14.

Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.

Cancer is the most common cause of mortality worldwide. There is dire need of modern strategies-such as surface modification of nanocarriers-to combat this global illness. Incorporation of active targeting ligands has arisen as a novel platform for specific tumor targeting. Read More

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The Synthesis, Characterization, Molecular Docking and In Vitro Antitumor Activity of Benzothiazole Aniline (BTA) Conjugated Metal-Salen Complexes as Non-Platinum Chemotherapeutic Agents.

Pharmaceuticals (Basel) 2022 Jun 15;15(6). Epub 2022 Jun 15.

Department of Molecular Medicine, School of Medicine, Kyungpook National University, 680, Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea.

Here, we describe the synthesis, characterization, and in vitro biological evaluation of a series of transition metal complexes containing benzothiazole aniline (BTA). We employed BTA, which is known for its selective anticancer activity, and a salen-type Schiff-based ligand to coordinate several transition metals to achieve selective and synergistic cytotoxicity. The compounds obtained were characterized by NMR spectroscopy, mass spectrometry, Fourier transform infrared spectroscopy, and elemental analysis. Read More

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[Tc]Tc-iFAP/SPECT Tumor Stroma Imaging: Acquisition and Analysis of Clinical Images in Six Different Cancer Entities.

Pharmaceuticals (Basel) 2022 Jun 9;15(6). Epub 2022 Jun 9.

Department of Radioactive Materials, Instituto Nacional de Investigaciones Nucleares, Ocoyoacac 52750, Mexico.

Fibroblast activation protein (FAP) is highly expressed on the cancer-associated fibroblasts (CAF) of the tumor stroma. Recently, we reported the preclinical evaluation and clinical biokinetics of a novel Tc-labeled FAP inhibitor radioligand ([Tc]Tc-iFAP). This research aimed to evaluate [Tc]Tc-iFAP for the tumor stroma imaging of six different cancerous entities and analyze them from the perspective of stromal heterogeneity. Read More

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In Vitro Evaluation of the Antioxidant Activity and Chemopreventive Potential in Human Breast Cancer Cell Lines of the Standardized Extract Obtained from the Aerial Parts of Zigzag Clover ( L.).

Pharmaceuticals (Basel) 2022 Jun 2;15(6). Epub 2022 Jun 2.

Department of Pharmacology, Chair of Pharmacology and Biology, Faculty of Health Sciences, Medical University of Lublin, 20-093 Lublin, Poland.

The aboveground parts of L. (zigzag clover), a little-known representative of the family Fabaceae, collected during flowering in a wild stand (Sławin-Szerokie district, Lublin, Poland), were used in this study. Our previous investigations confirmed the higher content of phytoestrogenic isoflavones (especially biochanin A and formononetin derivatives) in compared to the closely related medicinal plant (red clover) and the involvement of these compounds in anti-osteoporotic effects in ovariectomized female rats. Read More

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Design, Synthesis, In Vitro Biological Activity Evaluation and Stabilized Nanostructured Lipid Carrier Formulation of Newly Synthesized Schiff Bases-Based TMP Moieties.

Pharmaceuticals (Basel) 2022 May 28;15(6). Epub 2022 May 28.

Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Port Said University, Port Said 42526, Egypt.

A series of novel Schiff bases-based TMP moieties have been designed and synthesized as potential anticancer agents. The target Schiff bases were screened for their cytotoxic activity against the MDA-MB-231 breast cancer cell line. Most of the tested molecules revealed good cytotoxic activity, especially compounds   and . Read More

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Robustness Evaluation of a Deep Learning Model on Sagittal and Axial Breast DCE-MRIs to Predict Pathological Complete Response to Neoadjuvant Chemotherapy.

J Pers Med 2022 Jun 10;12(6). Epub 2022 Jun 10.

Oncologia Sperimentale e Biobanca, I.R.C.C.S. Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, 70124 Bari, Italy.

To date, some artificial intelligence (AI) methods have exploited Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) to identify finer tumor properties as potential earlier indicators of pathological Complete Response (pCR) in breast cancer patients undergoing neoadjuvant chemotherapy (NAC). However, they work either for sagittal or axial MRI protocols. More flexible AI tools, to be used easily in clinical practice across various institutions in accordance with its own imaging acquisition protocol, are required. Read More

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Prognostic Significance of Lymphocyte Infiltrate Localization in Triple-Negative Breast Cancer.

J Pers Med 2022 Jun 8;12(6). Epub 2022 Jun 8.

Department of Pathology, Forensic Medicine and Cytology, University Hospital Center Split, School of Medicine, University of Split, 21000 Split, Croatia.

High infiltration by tumor-infiltrating lymphocytes (TILs) is associated with favorable prognosis in different tumor types, but the clinical significance of their spatial localization within the tumor microenvironment is debated. To address this issue, we evaluated the accumulation of intratumoral TILs (itTILs) and stromal TILs (sTILs) in samples from 97 patients with early triple-negative breast cancer (TNBC) in the center (sTIL central) and periphery (sTIL peripheral) of tumor tissues. Moreover, the presence of primary and secondary lymphoid aggregates (LAs) and the expression levels of the cancer testis antigen (CTA), NY-ESO-1, and PD-L1 were explored. Read More

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