32,511 results match your criteria Breast Cancer Evaluation


The role of breath hold intensity modulated proton therapy for a case of left-sided breast cancer with IMN involvement. How protons compare with other conformal techniques?

Tech Innov Patient Support Radiat Oncol 2020 Sep 25;15:1-5. Epub 2020 May 25.

Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore.

Purpose: To evaluate the dosimetric impact of four different radiotherapy techniques for a case of left-sided breast cancer with Internal Mammary lymph Nodes (IMN) involvement.

Materials And Methods: To identify the best radiotherapy technique for this patient, four methods were compared: 3D Conformal Radiotherapy (3D-CRT), Volumetric Modulated Arc Therapy (VMAT), Tomotherapy (TOMO) and Intensity Modulated Proton Therapy (IMPT). Patient was treated using deep inspiration breath-hold (DIBH) technique. Read More

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http://dx.doi.org/10.1016/j.tipsro.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256639PMC
September 2020

Evaluation of breast screening strategies in a high risk breast and ovarian cancer clinic.

Gynecol Oncol Rep 2020 Aug 22;33:100587. Epub 2020 May 22.

University of Virginia Health System, Division of Gynecologic Oncology, United States.

Recent data suggest that BRCA mutation carriers younger than 40 may not benefit from mammography in addition to MRI. Our objective was to evaluate screening modalities utilized in a high-risk population. Clinicopathologic data were abstracted for patients followed in a high risk clinic from 2007 to 2017. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256456PMC

ΔKi67 proliferation index as independent predictive and prognostic factor of outcome in luminal breast cancer: data from neoadjuvant letrozole-based treatment.

Tumour Biol 2020 Jun;42(6):1010428320925301

Department of Medical, Surgical & Health Sciences, Cattinara Teaching Hospital, University of Trieste, Trieste, Italy.

A key tool for monitoring breast cancer patients under neoadjuvant treatment is the identification of reliable predictive markers. Ki67 has been identified as a prognostic and predictive marker in ER-positive breast cancer. Ninety ER-positive, HER2 negative locally advanced breast cancer patients received letrozole (2. Read More

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http://dx.doi.org/10.1177/1010428320925301DOI Listing

Consumption of Fish and ω-3 Fatty Acids and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies.

Adv Nutr 2020 Jun 3. Epub 2020 Jun 3.

Internal Medicine V, Department of Hematology and Oncology, Medical University Innsbruck, Innsbruck, Austria.

Multiple studies have suggested that ω-3 fatty acid intake may have a protective effect on cancer risk; however, its true association with cancer risk remains controversial. We performed an umbrella review of meta-analyses to summarize and evaluate the evidence for the association between ω-3 fatty acid intake and cancer outcomes. We searched PubMed, Embase, and the Cochrane Database of Systematic Reviews from inception to December 1, 2018. Read More

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http://dx.doi.org/10.1093/advances/nmaa055DOI Listing

PET/CT of breast cancer regional nodal recurrences: an evaluation of contouring atlases.

Radiat Oncol 2020 Jun 1;15(1):136. Epub 2020 Jun 1.

Department of Radiation Oncology, BC Cancer, Vancouver Centre, Vancouver, British Columbia, Canada.

Background: To validate the Radiation Therapy Oncology Group (RTOG) and European Society for Radiotherapy and Oncology (ESTRO) breast cancer nodal clinical target volumes (CTVs) and to investigate the Radiotherapy Comparative Effectiveness Consortium (RADCOMP) Posterior Neck volume in relation to regional nodal recurrences (RNR).

Methods: From a population-based database, 69 patients were identified who developed RNR after curative treatment for breast cancer. RNRs were detected with 18-fluorodeoxyglucose-positron emission tomography-computed tomography (PET/CT). Read More

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http://dx.doi.org/10.1186/s13014-020-01576-6DOI Listing

Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide.

Int J Mol Sci 2020 May 29;21(11). Epub 2020 May 29.

Genome Analysis Center, Yamanashi Central Hospital, Kofu 400-8506, Japan.

variants are prognostic biomarkers for hereditary breast and/or ovarian cancer (HBOC) syndrome and predictive biomarkers for PARP inhibition. In this study, we benchmarked the classification of variants from patients with HBOC-related cancer using MH BRCA, a novel computational technology that combines the ACMG guidelines with expert-curated variant annotations. Evaluation of variants ( = 1040) taken from four HBOC studies showed strong concordance within the pathogenic (98. Read More

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http://dx.doi.org/10.3390/ijms21113895DOI Listing

Synthesis, Characterization and Biological Evaluation of Metal Adamantyl 2-Pyridylhydrazone Complexes.

Molecules 2020 May 29;25(11). Epub 2020 May 29.

Department of Chemistry, Faculty of Science, The University of Jordan, Amman 11942, Jordan.

Four new complexes derived from adamantly containing hydrazone () ligand with Cu(II) (), Co(II) (), Ni(II) () and Zn(II) (), have been synthesized and characterized using different physicochemical methods. The structure of the ligand and its copper complex have been established by single-crystal X-ray diffraction direct methods, which reveal that complex has distorted square-pyramidal geometry. Complexes - are screened against seven human cancer cell lines namely, breast cancer cell lines (MCF7, T47D, MDA-MB-231), prostate cancer cell lines (PC3, DU145) and the colorectal cancer cell line Coco-2, for their antiproliferative activities. Read More

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http://dx.doi.org/10.3390/molecules25112530DOI Listing

TRPM4 is overexpressed in breast cancer associated with estrogen response and epithelial-mesenchymal transition gene sets.

PLoS One 2020 2;15(6):e0233884. Epub 2020 Jun 2.

Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Ion channels form an important class of drug targets in malignancies. Transient receptor potential cation channel subfamily M member 4 (TRPM4) plays oncological roles in various solid tumors. Herein, we examined TRPM4 protein expression profile by immunohistochemistry (IHC) in breast cancer cases compared with normal breast ducts, its association with clinico-demographical parameters, and its potential function in breast cancers by Gene Set Enrichment Analysis (GSEA). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233884PLOS

Computational and in vitro characterization of ICY-5: A potential candidate promoting mitochondrial apoptosis via the c-MET and STAT3 pathways.

J Cell Physiol 2020 Jun 2. Epub 2020 Jun 2.

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.

Targeted chemotherapy remains the primary choice in controlling various forms of breast cancer (BC) due to its heterogenous gene expressions in various subtypes. In silico and in vitro evaluation of ICY-5, a novel arylidene analogue against c-MET, was performed. ICY-5 exhibited a docking score of -9. Read More

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http://dx.doi.org/10.1002/jcp.29830DOI Listing

Telephone interventions for symptom management in adults with cancer.

Cochrane Database Syst Rev 2020 Jun 2;6:CD007568. Epub 2020 Jun 2.

Institute of Health & Society, Newcastle University, Newcastle upon Tyne, UK.

Background: People with cancer experience a variety of symptoms as a result of their disease and the therapies involved in its management. Inadequate symptom management has implications for patient outcomes including functioning, psychological well-being, and quality of life (QoL). Attempts to reduce the incidence and severity of cancer symptoms have involved the development and testing of psycho-educational interventions to enhance patients' symptom self-management. Read More

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http://dx.doi.org/10.1002/14651858.CD007568.pub2DOI Listing

Single-arm, open-label phase 2 trial of pembrolizumab in patients with leptomeningeal carcinomatosis.

Nat Med 2020 Jun 1. Epub 2020 Jun 1.

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

An increasing fraction of patients with metastatic cancer develop leptomeningeal dissemination of disease (LMD), and survival is dismal. We conducted a single-arm, phase 2 study of pembrolizumab in patients with solid tumor malignancies and LMD (NCT02886585). Patients received 200 mg of pembrolizumab intravenously every 3 weeks until definitive progression or unacceptable toxicity. Read More

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http://dx.doi.org/10.1038/s41591-020-0918-0DOI Listing

Pubertal Development: What's Normal/What's Not.

Clin Obstet Gynecol 2020 May 29. Epub 2020 May 29.

Division of Adolescent and Transition Medicine, Cincinnati Children's Hospital Medical Center.

Onset of puberty, as defined by breast stage 2, appears to be starting at younger ages since the 1940s. There is an ongoing controversy regarding what is normative, as well as what is normal, and the evaluation that is deemed necessary for girls maturing before 8 years of age. There are potential implications of earlier pubertal timing, including psychosocial consequences during adolescence, as well as longer term risks, such as breast cancer and cardiometabolic risks. Read More

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http://dx.doi.org/10.1097/GRF.0000000000000537DOI Listing

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation.

Molecules 2020 May 28;25(11). Epub 2020 May 28.

Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt.

A multicomponent synthesis was empolyed for the synthesis of ethyl 2-amino-4,5,6,7-tetrahydrobenzo[]thiophene-3-carboxylate . An interesting cyclization was obtained when the amino-ester reacted with ethyl isothiocyanate to give the benzo[4,5]thieno[2,3-][1,3]thiazin-4-one . Acylation of the amino-ester with chloroacetyl chloride in DCM and EtN afforded the acylated ester . Read More

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http://dx.doi.org/10.3390/molecules25112523DOI Listing

Patient satisfaction in one-stage immediate breast reconstruction after mastectomy: A multi-center comparative patient evaluation of prosthesis, LDMF, and TRAM techniques.

Medicine (Baltimore) 2020 May;99(22):e19991

Department of Breast Surgery, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

To analyze patient satisfaction and the predictive factors characterizing three types of one-stage immediate breast reconstruction (IBR) after mastectomy, including prosthesis, latissimus dorsi myocutaneous flap (LDMF), transverse rectus abdominis myocutaneous (TRAM) flap techniques.Data were collected via face-to-face or telephone interviews from eight breast centers in China from January 2012 to December 2016. A standardized questionnaire that evaluated the general satisfaction and aesthetic satisfaction was sent to patients who had undergone IBR. Read More

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http://dx.doi.org/10.1097/MD.0000000000019991DOI Listing
May 2020
5.723 Impact Factor

Evaluation of Cytotoxicity of Different Part Extracts of Ipomoea turpethum against Breast Cancer Cell Lines.

J Environ Pathol Toxicol Oncol 2020 ;39(1):51-60

Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi 110062, India.

The aim of the present study was to explore the anti-breast cancer activity of the plant I. turpethum together with the comparative analysis of the cytotoxicity of the extracts from different parts of the plant. The gas chromatography-mass spectrometry (GC-MS) analysis of the plant revealed the identification of 71 compounds. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2020031451DOI Listing

Adult Onset Still's Disease and Radiotherapy treatment for breast cancer: Case report about management of this rare association and literature review.

Rep Pract Oncol Radiother 2020 Jul-Aug;25(4):527-532. Epub 2020 May 22.

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, UOC di Radioterapia Oncologica, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Roma, Italy.

Aim: This manuscript focuses on the first experience in literature of a patient with a complicated Adult Onset Still's Disease-related heart failure who thereafter underwent adjuvant radiotherapy for left breast cancer.

Background: AOSD is a rare autoimmune inflammation-related disease, in which life-threatening pulmonary and cardiac complications can occur. In literature, AOSD is often associated with cancer, as paraneoplastic syndrome, but there are few data about primary AOSD and management of oncological therapies. Read More

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http://dx.doi.org/10.1016/j.rpor.2020.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251537PMC

A measure of case complexity for streamlining workflow in multidisciplinary tumor boards: Mixed methods development and early validation of the MeDiC tool.

Cancer Med 2020 May 31. Epub 2020 May 31.

Centre for Implementation Science, Health Service and Population Research Department, King's College London, London, UK.

Background And Objective: There is increasing emphasis in cancer care globally for care to be reviewed and managed by multidisciplinary teams (ie, in tumor boards). Evidence and recommendations suggest that the complexity of each patient case needs to be considered as care is planned; however, no tool currently exists for cancer teams to do so. We report the development and early validation of such a tool. Read More

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http://dx.doi.org/10.1002/cam4.3026DOI Listing

Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis.

World J Surg Oncol 2020 May 29;18(1):112. Epub 2020 May 29.

Department of Thyroid and Breast Surgery, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China.

Objective: To investigate whether preoperative localization of sentinel lymph node (SLN) by contrast-enhanced ultrasound (CEUS) can further improve the accuracy of sentinel lymph node biopsy (SLNB).

Method: Collect published literatures or conference reports by searching electronic databases. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) evaluation method is used to evaluate the quality of the screened literatures. Read More

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http://dx.doi.org/10.1186/s12957-020-01890-zDOI Listing

Radiotherapy dose distribution prediction for breast cancer using deformable image registration.

Biomed Eng Online 2020 May 29;19(1):39. Epub 2020 May 29.

Key Laboratory of Radiation Physics and Technology, Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, China.

Background: Radiotherapy treatment planning dose prediction can be used to ensure plan quality and guide automatic plan. One of the dose prediction methods is incorporating historical treatment planning data into algorithms to estimate the dose-volume histogram (DVH) of organ for new patients. Although DVH is used extensively in treatment plan quality and radiotherapy prognosis evaluation, three-dimensional dose distribution can describe the radiation effects more explicitly. Read More

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http://dx.doi.org/10.1186/s12938-020-00783-2DOI Listing

Systematic screening as a tool for individualized rehabilitation following primary breast cancer treatment: study protocol for the ReScreen randomized controlled trial.

BMC Cancer 2020 May 29;20(1):484. Epub 2020 May 29.

Department of Health Sciences, Lund University, Box 157, 221 00, Lund, Sweden.

Background: It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at risk of developing chronic distress requiring complex interventions; however, how to early identify and meet these women's needs is unknown, leaving them with suboptimal chances of rehabilitation. The aim of the ReScreen study is to develop a model for and evaluate the effect of screening-based, individualized rehabilitation following primary BC treatment. Read More

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http://dx.doi.org/10.1186/s12885-020-06815-3DOI Listing

Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells.

Biomed Pharmacother 2020 May 26;128:110243. Epub 2020 May 26.

Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, K.K. Birla Goa Campus, NH-17B, Zuarinagar, Goa 403726, India. Electronic address:

Piperlongumine (PL), a herbal drug extracted from long pepper (Piper longum L), is known for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has been evaluated in cancer models like breast, pancreatic, gastric, hepatocellular and lung carcinoma, there is no report on its bio-activity evaluation in intestinal cancers. Here, we report the anti-neoplastic potential of PL against human intestinal carcinoma in-vitro and its possible mechanisms of action. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110243DOI Listing

Evaluation of the modified Regnault “B” technique as a standard level II oncoplastic breast-conserving surgery

Orv Hetil 2020 06;161(24):1002-1011

Daganatsebészeti Központ, Emlő-Lágyrész Daganatsebészeti Osztály,Országos Onkológiai Intézet Budapest, Ráth György u. 7-9., 1122.

Introduction And Aim: This study aimed to describe the modified Regnault "B" oncoplastic technique as a standard volume-displacement level II oncoplastic breast-conserving surgery and the related clinicopathological study.

Method: A retrospective, single-centre study was performed between April 2012 and October 2018 involving 215 breast-cancer patients. Patient characteristics and postoperative complications were recorded, and the quality of life was rated by questionnaires. Read More

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http://dx.doi.org/10.1556/650.2020.31738DOI Listing

Pathologic evaluation of response to neoadjuvant therapy drives treatment changes and improves long-term outcomes for breast cancer patients.

Breast J 2020 May 29. Epub 2020 May 29.

Massachusetts General Hospital, Boston, Massachusetts, USA.

Systemic therapy for breast cancer may be given before (neoadjuvant) or after (adjuvant) surgery. When neoadjuvant systemic therapy is given, response to treatment can be evaluated. However, some prognostic information (for example, pathologic tumor size pretreatment) is then lost and pathologic evaluation of breast specimens after neoadjuvant therapy is more difficult. Read More

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http://dx.doi.org/10.1111/tbj.13864DOI Listing

Use of Symmetry Assessment Methods in the Context of Breast Surgery.

Aesthetic Plast Surg 2020 May 28. Epub 2020 May 28.

Anatomy and Embryology Unit, Faculty of Medicine, University of Castilla-La Mancha (UCLM), Albacete, Spain.

Background: Different procedures are available to help clinicians evaluate symmetry and cosmetic results in an objective manner after conservative breast cancer surgery. However, there are no similar methods in esthetic breast surgery, where the subjective assessment of the surgeon or the patient is usually considered the gold standard. The aim of this study is to evaluate the application of four software programs in the context of esthetic breast surgery and contrast their results with those of the subjective evaluation by a series of healthcare professionals. Read More

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http://dx.doi.org/10.1007/s00266-020-01755-6DOI Listing

Transaxillary Nipple-Sparing Mastectomy and Direct-to-Implant Breast Reconstruction Using a Simplified Endoscopic Approach: Indications, Cosmetic Outcomes and Technical Refinements.

Aesthetic Plast Surg 2020 May 28. Epub 2020 May 28.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, UOC Chirurgia Plastica, Università Cattolica del "Sacro Cuore", Fondazione Policlinico Universitario A. Gemelli IRCSS, Largo A. Gemelli 8, 00169, Rome, Italy.

Background: The increasing demand for further aesthetic outcome improvement in implant-based breast reconstruction after nipple-sparing mastectomy (NSM) leads to major novelties, including endoscopic and robotic NSM with the aim to limit scar visibility. In this paper, we report our experience with a novel and simplified surgical approach-single-axillary-incision non-endoscopic NSM and node surgery followed by an endoscopic DTI breast reconstruction-by focusing on reconstructive indications, technical refinements and aesthetic outcomes.

Methods: Between June 2016 and October 2019, 14 women underwent this novel technique using definitive anatomical silicone gel filled, totaling 20 breasts. Read More

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http://dx.doi.org/10.1007/s00266-020-01792-1DOI Listing

Biomarkers of tumor invasiveness in proteomics (Review).

Int J Oncol 2020 May 28. Epub 2020 May 28.

Paul Papin ICO Cancer Center, CRCINA, Inserm, Université d'Angers, F‑44000 Nantes, France.

Over the past two decades, quantitative proteomics has emerged as an important tool for deciphering the complex molecular events involved in cancers. The number of references involving studies on the cancer metastatic process has doubled since 2010, while the last 5 years have seen the development of novel technologies combining deep proteome coverage capabilities with quantitative consistency and accuracy. To highlight key findings within this huge amount of information, the present review identified a list of tumor invasive biomarkers based on both the literature and data collected on a biocollection of experimental cell lines, tumor models of increasing invasiveness and tumor samples from patients with colorectal or breast cancer. Read More

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http://dx.doi.org/10.3892/ijo.2020.5075DOI Listing

Australian general practitioners' attitudes and knowledge of sentinel lymph node biopsy in melanoma management.

Aust J Gen Pract 2020 06;49(6):355-362

MPH (Hons), PhD, Head of Cancer Epidemiology and Prevention Research Group, Sydney School of Public Health and Melanoma Institute Australia, University of Sydney, NSW; Professor of Cancer Epidemiology, Sydney Medical School, University of Sydney, NSW.

Background And Objectives: In Australia, the uptake of the sentinel lymph node biopsy (SLNB) appears low despite clinical practice guideline recommendations. The aim of this study was to describe the knowledge and attitudes of general practitioners (GPs) to SLNB.

Method: GPs were recruited at an annual conference and a skin cancer skills workshop, and using GP professional communications. Read More

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http://dx.doi.org/10.31128/AJGP-10-19-5138DOI Listing

Design, synthesis, and biological evaluation of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents.

Eur J Med Chem 2020 May 1;198:112396. Epub 2020 May 1.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, 250012, PR China. Electronic address:

A novel series of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed antitumor agents were designed, synthesized, biologically evaluated. Compounds 3n, 3o and 3j proved to be good NQO1 substrates that showed increased metabolic rates relative to that of β-lapachone. In addition, 3n, 3o and 3j potently inhibited the growth of NQO1-rich breast cancer MCF-7 cell, liver hepatocellular HepG2 cell, and lung cancer A549 cell. Read More

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http://dx.doi.org/10.1016/j.ejmech.2020.112396DOI Listing

Phase II Study of AZD4547 in Patients With Tumors Harboring Aberrations in the FGFR Pathway: Results From the NCI-MATCH Trial (EAY131) Subprotocol W.

J Clin Oncol 2020 May 28:JCO1902630. Epub 2020 May 28.

Massachusetts General Hospital, Boston, MA.

Purpose: NCI-MATCH is a nationwide, histology-agnostic, signal-finding, molecular profile-driven trial for patients with refractory cancers, lymphomas, or myelomas. Patients with tumors harboring actionable aberration(s) in fibroblast growth factor receptor () were treated with AZD4547, an oral FGFR1-3 inhibitor.

Methods: Patients' tumors were screened by next-generation sequencing for predefined amplification, activating mutations, or fusions. Read More

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http://dx.doi.org/10.1200/JCO.19.02630DOI Listing

A phase II trial of cabozantinib in hormone-receptor positive breast cancer with bone metastases.

Oncologist 2020 May 28. Epub 2020 May 28.

Massachusetts General Hospital Cancer Center, Boston, MA, 02114.

Background: We assessed the antitumor activity of cabozantinib, a potent multi-receptor oral tyrosine kinase inhibitor, in patients with hormone-receptor positive breast cancer with bone metastases.

Patients And Methods: In this single-arm multicenter phase II study, patients received an initial starting dose of 100 mg, later reduced to 60 mg per day. The primary endpoint was the bone scan response rate. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0127DOI Listing

A New Computer-Aided Diagnosis System with Modified Genetic Feature Selection for BI-RADS Classification of Breast Masses in Mammograms.

Biomed Res Int 2020 11;2020:7695207. Epub 2020 May 11.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Mammography remains the most prevalent imaging tool for early breast cancer screening. The language used to describe abnormalities in mammographic reports is based on the Breast Imaging Reporting and Data System (BI-RADS). Assigning a correct BI-RADS category to each examined mammogram is a strenuous and challenging task for even experts. Read More

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http://dx.doi.org/10.1155/2020/7695207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238352PMC

Survival Rate and Prognostic Factors among Iranian Breast Cancer Patients.

Iran J Public Health 2020 Feb;49(2):341-350

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Survival time is one of the indicators used for evaluation of the quality of care in different types of malignancies, including breast cancer. The present study aimed to estimate the survival rate of breast cancer and its related factors among Iranian patients.

Methods: Overall, 3148 cases of breast cancer who referred to the Cancer Research Center in Shahid Beheshti University of Medical Sciences, Tehran, Iran during 1994-2017 participated in this longitudinal study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231718PMC
February 2020

Indocyanine Green Fluorescence Versus Blue Dye or Radioisotope Regarding Detection Rate of Sentinel Lymph Node Biopsy and Nodes Removed in Breast Cancer: A Systematic Review and Meta-Analysis.

Asian Pac J Cancer Prev 2020 May 1;21(5):1187-1195. Epub 2020 May 1.

Division of Head Neck and Breast Surgery, Department of Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Either blue dye (BD) or radioisotope (RI) is mainly used for sentinel lymph node biopsy (SLNB) in breast cancer patients. Unlike the BD, RI has lower false-negative rate of SLNB. However, its lymphoscintigraphy, difficulty in preoperative injection, and undetected sentinel lymph nodes in some cases cause surgeons to rely only on BD. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1187DOI Listing

Effectiveness and Safety of Acupuncture Moxibustion Therapy Used in Breast Cancer-Related Lymphedema: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2020 11;2020:3237451. Epub 2020 May 11.

Department of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, China.

Objective: To evaluate the effectiveness and safety of acupuncture moxibustion therapy (AMT) for the breast cancer-related lymphedema (BCRL).

Methods: Four English databases (MEDLINE, PubMed, Embase, and Cochrane CENTRAL) and four Chinese databases were searched from their inception to Feb 1, 2020. Eligible randomized controlled trials (RCTs) investigating AMT against any type of controlled intervention in patients for BCRL and assessing clinically relevant outcomes (total effective rate, circumference difference, and Karnofsky performance score) were included. Read More

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http://dx.doi.org/10.1155/2020/3237451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240793PMC

Effectiveness of a Global Multidisciplinary Supportive and Educational Intervention in Thermal Resort on Anthropometric and Biological Parameters, and the Disease-Free Survival after Breast Cancer Treatment Completion (PACThe).

J Oncol 2020 5;2020:4181850. Epub 2020 May 5.

Jean Perrin Comprehensive Cancer Centre, Department of Oncogenetics, 58 Rue Montalembert, 63011 Clermont-Ferrand, France.

A growing knowledge highlights the strong benefit of regular physical activity in the management of breast cancer patients, but few studies have considered biological parameters in their outcomes. In the prospective randomised trial after breast cancer treatment completion "PACThe," we determined the effects of physical activity and nutritional intervention on the biological and anthropometric status of patients after one year of follow-up, and clarified the link between biomarkers at allocation and disease-free survival. 113 patients from the population of the "PACThe" study ( = 251) were analysed for biological parameters. Read More

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http://dx.doi.org/10.1155/2020/4181850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222596PMC

Enantioselective Synthesis of Planar Chiral Ferrocifens that Show Chiral Discrimination in Antiproliferative Activity on Breast Cancer Cells.

Chembiochem 2020 May 26. Epub 2020 May 26.

University College Dublin, Chemistry, Belfield, 4, Dublin, IRELAND.

The design and first enantioselective synthesis of a series of chiral ferrocifens and ferrociphenols was realised via enantioselective palladium-catalysed intramolecular direct C-H bond activation followed by McMurry coupling. Biological evaluation revealed moderate anticancer activities on breast cancer cells and evidence of chiral discrimination between enantiomers. Treatment of these novel ferrocifens with Ag 2 O revealed that these systems are unable to form a neutral quinone methide, yet still demonstrate marked antiproliferative properties versus both the hormone-dependent MCF-7 and hormone-independent MDA-MB-231 cell lines. Read More

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http://dx.doi.org/10.1002/cbic.202000311DOI Listing

Identification of risk factors for central nervous system metastasis in patients with breast cancer with neurologic symptoms.

Cancer 2020 May 26. Epub 2020 May 26.

General Director, National Institute of Cancer, Mexico City, Mexico.

Background: The current study was performed to identify factors that are present at the time of breast cancer (BC) diagnosis that are associated with a higher rate of central nervous system metastasis (CNSm).

Methods: The authors analyzed a database of patients with a confirmed diagnosis of BC who were referred for a neuro-oncology consultation at the National Cancer Institute in Mexico City, Mexico, from June 2009 to June 2017. Information was collected prospectively and included demographic, pathologic, and clinical data at the time of diagnosis of BC. Read More

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http://dx.doi.org/10.1002/cncr.32928DOI Listing

Nonmass Enhancement Breast Lesions: Diagnostic Performance of Kinetic Assessment on Ultrafast and Standard Dynamic Contrast-Enhanced MRI in Comparison With Morphologic Evaluation.

AJR Am J Roentgenol 2020 May 26:1-8. Epub 2020 May 26.

Department of Radiology, University of Chicago, Chicago, IL.

The purpose of this article was to evaluate the diagnostic performance of the kinetic parameters of ultrafast and standard dynamic contrast-enhanced MRI (DCE-MRI) compared with morphologic evaluation in differentiating benign from malignant nonmass enhancement (NME) breast lesions. A total of 77 consecutive patients with 77 NMEs (23 benign and 54 malignant) underwent 3-T MRI, including one unenhanced and eight contrast-enhanced ultrafast DCE-MRI scans (7-second scans) and standard DCE-MRI scans. The two readers evaluated the lesions' likelihood of malignancy on a continuous scale from 0 to 100% as the morphologic score using standard DCE-MRI. Read More

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http://dx.doi.org/10.2214/AJR.19.21920DOI Listing

A multi-stakeholder approach in optimising patients' needs in the benefit assessment process of new metastatic breast cancer treatments.

Breast 2020 May 10;52:78-87. Epub 2020 May 10.

Canadian Breast Cancer Network, Ottawa, ON, Canada.

There is a growing understanding as science evolves that different cancer types require different approaches to treatment evaluation, especially in the metastatic stages. The introduction of new metastatic breast cancer (MBC) treatments may be hindered by several elements, including the availability of relevant evidence related to disease-specific outcomes, the benefit assessment process around the evaluation of the clinical benefit and the patients' need of new treatments. The Steering Committee (SC) found that not all issues relevant to MBC patients are consistently considered in the current benefit assessment process of new treatments. Read More

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http://dx.doi.org/10.1016/j.breast.2020.04.011DOI Listing

In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies.

Bioorg Chem 2020 May 16;100:103951. Epub 2020 May 16.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt. Electronic address:

In this study, anti-proliferative effects of twenty-seven indeno[1,2-b]quinoxalin-11-one derivatives were investigated in three human cancer cell lines, namely: the colon cancer cell line HCT-116, the liver cancer cell line HepG-2, and the breast cancer cell line MCF-7. Among them, 5, 6, 13, 14a, b and 15d-f derivatives displayed excellent anti-proliferative activities against the three tested cell lines compared to the reference standard Imatinib. Therefore, they were selected for further studies. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103951DOI Listing

Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment.

Bioorg Chem 2020 May 17;100:103942. Epub 2020 May 17.

Life and Health Sciences Research Institute (ICVS), University of Minho, Campus of Gualtar, Braga, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. Electronic address:

A selection of new chromeno[2,3-b]pyridines was prepared from chromenylacrylonitriles and N-substituted piperazines, using a novel and efficient synthetic procedure. The compounds were tested for their anticancer activity using breast cancer cell lines MCF-7, Hs578t and MDA-MB-231 and the non-neoplastic cell line MCF-10A for toxicity evaluation. In general, compounds showed higher activity towards the luminal breast cancer subtype (MCF-7), competitive with the reference compound Doxorubicin. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103942DOI Listing
May 2020
2.152 Impact Factor

Heart sparing radiotherapy in breast cancer: the importance of baseline cardiac risks.

Radiat Oncol 2020 May 24;15(1):117. Epub 2020 May 24.

Department of Radiation Oncology, University Hospital, LMU Munich, Marchioninistraße 15, 81377, Munich, Germany.

Background: Patients with left-sided breast cancer have an increased risk of cardiovascular disease (CVD) after radiotherapy (RT). While the awareness of cardiac toxicity has increased enormously over the last decade, the role of individual baseline cardiac risks has not yet been systematically investigated. Aim of the present study was to evaluate the impact of baseline CVD risks on radiation-induced cardiac toxicity. Read More

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http://dx.doi.org/10.1186/s13014-020-01520-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245801PMC

S-Detect characterization of focal solid breast lesions: a prospective analysis of inter-reader agreement for US BI-RADS descriptors.

J Ultrasound 2020 May 23. Epub 2020 May 23.

Department of Biomedicine, Neuroscience and Advanced Diagnostic (Bi.N.D.), University Hospital "Policlinico P. Giaccone", Via Del Vespro 129, 90127, Palermo, Italy.

Background: To assess inter-reader agreement for US BI-RADS descriptors using S-Detect: a computer-guided decision-making software assisting in US morphologic analysis.

Methods: 73 solid focal breast lesions (FBLs) (mean size: 15.9 mm) in 73 consecutive women (mean age: 51 years) detected at US were randomly and independently assessed according to the BI-RADS US lexicon, without and with S-Detect, by five independent reviewers. Read More

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http://dx.doi.org/10.1007/s40477-020-00476-5DOI Listing

Diffusion-weighted MRI at 3.0 T for detection of occult disease in the contralateral breast in women with newly diagnosed breast cancer.

Breast Cancer Res Treat 2020 May 23. Epub 2020 May 23.

Department of Radiology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Republic of Korea.

Purpose: Diffusion-weighted magnetic resonance imaging (DW-MRI) offers unenhanced method to detect breast cancer without cost and safety concerns associated with dynamic contrast-enhanced (DCE) MRI. Our purpose was to evaluate the performance of DW-MRI at 3.0T in detection of clinically and mammographically occult contralateral breast cancer in patients with unilateral breast cancer. Read More

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http://dx.doi.org/10.1007/s10549-020-05697-0DOI Listing

Real-world evaluation of effectiveness and tolerance of chemotherapy for early-stage breast cancer in older women.

Breast Cancer Res Treat 2020 May 23. Epub 2020 May 23.

Division of Hematology/Oncology, West Cancer Center/University of Tennessee Health Science Center, 7945 Wolf River Boulevard, Germantown, Memphis, TN, USA.

Purpose: Older patients with early-stage breast cancer (ESBC) tend to receive less aggressive treatment, have higher mortality rates, and are underrepresented in clinical trials. Outcomes, tolerance and toxicity of chemotherapy are underreported. Thus, we assessed the outcomes of chemotherapy in the real-world in a community oncology setting. Read More

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http://dx.doi.org/10.1007/s10549-020-05684-5DOI Listing

Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation.

J Ethnopharmacol 2020 May 21:112984. Epub 2020 May 21.

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China. Electronic address:

Ethnopharmacological Relevance: The rhizome of Anemone raddeana Regel (A. raddeana) is a famous traditional Chinese medicine (TCM) recorded in Chinese Pharmacopeia for the treatment of carbuncle and swelling. Carbuncle swollen is an explanation of tumor in the theory of TCM and softening and resolving hard mass effects are one of the important pharmacological activities of A. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112984DOI Listing

MaskMitosis: a deep learning framework for fully supervised, weakly supervised, and unsupervised mitosis detection in histopathology images.

Med Biol Eng Comput 2020 May 22. Epub 2020 May 22.

School of Computer Science and Technology, Huazhong University of Science and Technology (HUST), Wuhan, People's Republic of China.

Counting the mitotic cells in histopathological cancerous tissue areas is the most relevant indicator of tumor grade in aggressive breast cancer diagnosis. In this paper, we propose a robust and accurate technique for the automatic detection of mitoses from histological breast cancer slides using the multi-task deep learning framework for object detection and instance segmentation Mask RCNN. Our mitosis detection and instance segmentation framework is deployed for two main tasks: it is used as a detection network to perform mitosis localization and classification in the fully annotated mitosis datasets (i. Read More

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http://dx.doi.org/10.1007/s11517-020-02175-zDOI Listing

Hypofractionated whole breast irradiation after IORT treatment: evaluation of acute toxicity and cosmesis.

Clin Transl Oncol 2020 May 22. Epub 2020 May 22.

Breast Cancer Unit, Centro Oncológico Integral Canario (COIC), Hospital Universitario San Roque, Dolores de la Rocha 5, 35001, Las Palmas, GC, Spain.

Introduction: Hypofractionated whole breast irradiation (HWBI) is the current standard of treatment after breast conservative surgery (BCS). Intraoperative radiotherapy (IORT) must be associated to WBI in patients showing high-risk factors of local recurrence in the definitive pathology report. The aim of this trial was to evaluate, for the first time, the acute toxicity and cosmesis of HWBI after photon-IORT. Read More

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http://dx.doi.org/10.1007/s12094-020-02400-zDOI Listing

High-throughput functional evaluation of BRCA2 variants of unknown significance.

Nat Commun 2020 May 22;11(1):2573. Epub 2020 May 22.

Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, 104-0045, Japan.

Numerous nontruncating missense variants of the BRCA2 gene have been identified, but there is a lack of convincing evidence, such as familial data, demonstrating their clinical relevance and they thus remain unactionable. To assess the pathogenicity of variants of unknown significance (VUSs) within BRCA2, here we develop a method, the MANO-B method, for high-throughput functional evaluation utilizing BRCA2-deficient cells and poly (ADP-ribose) polymerase (PARP) inhibitors. The estimated sensitivity and specificity of this assay compared to those of the International Agency for Research on Cancer classification system is 95% and 95% (95% confidence intervals: 77-100% and 82-99%), respectively. Read More

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http://dx.doi.org/10.1038/s41467-020-16141-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244490PMC