30,071 results match your criteria Breast Cancer Evaluation


Biomarker discordance between primary breast cancer and bone or bone marrow metastases.

Jpn J Clin Oncol 2019 Feb 22. Epub 2019 Feb 22.

Department of Breast and Medical Oncology, National Cancer Center Hospital.

Background: Discordance in biomarker expression between primary and metastatic tumor sites has been reported in several studies; yet, few have examined this feature in bone lesions.

Methods: We retrospectively enrolled patients with breast cancer metastasis to the bone or bone marrow, excluding cases where samples from both the primary and metastatic lesions were not available. Expression patterns of the estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2) and Ki67 were compared in primary tumors and bone or bone marrow lesions. Read More

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http://dx.doi.org/10.1093/jjco/hyz018DOI Listing
February 2019

Genomic, transcriptomic, epigenetic, and immune profiling of mucinous breast cancer.

J Natl Cancer Inst 2019 Feb 21. Epub 2019 Feb 21.

Breast Cancer Translational Research Laboratory, Université Libre de Bruxelles, Institut Jules Bordet, U-CRC, Brussels, Belgium.

While invasive ductal breast cancer (IDC) represents the most common histological type of breast cancer, minor subtypes exist such as mucinous breast cancer (MuBC). MuBC patients are generally older and have an excellent prognosis while at the pathological level, these tumors present with cells floating in extracellular mucin. To unravel the molecular architecture of MuBC, we applied low pass whole genome sequencing and microscopic evaluation of stromal tumor infiltrating lymphocytes (TIL) to 30 MuBC from a retrospective institutional cohort. Read More

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http://dx.doi.org/10.1093/jnci/djz023DOI Listing
February 2019

Psychosocial distress in oncology: using the distress thermometer for assessing risk classes.

Support Care Cancer 2019 Feb 20. Epub 2019 Feb 20.

Psycho-Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Viale Orazio Flacco 65, 70124, Bari, BA, Italy.

Purpose: Cancer patients often suffer for psychological distress, which can compromise their quality of life. Our study aimed to recognize risk classes for the development of psychosocial distress.

Methods: Three hundred seventy-two adult cancer patients were assessed by the Distress Thermometer (DT) and Problem List at the National Cancer Research Centre "Giovanni Paolo II" of Bari. Read More

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http://dx.doi.org/10.1007/s00520-019-04694-4DOI Listing
February 2019

Examining the "usual" in usual care: a critical review and recommendations for usual care conditions in psycho-oncology.

Support Care Cancer 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, University of California Los Angeles, Los Angeles, CA, 90095, USA.

Purpose: Within psycho-oncology clinical trials, usual care (UC) represents a common and important control condition. Yet recent shifts in oncology, coupled with insufficient description of such conditions, threaten to render UC increasingly difficult to define and interpret. This paper offers evidence of these shifts and recommendations for addressing them. Read More

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http://dx.doi.org/10.1007/s00520-019-04677-5DOI Listing
February 2019

Differential Oxygenation in Tumor Microenvironment Modulates Macrophage and Cancer Cell Crosstalk: Novel Experimental Setting and Proof of Concept.

Front Oncol 2019 6;9:43. Epub 2019 Feb 6.

Unitat de Biofísica i Bioenginyeria, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona, Barcelona, Spain.

Hypoxia is a common characteristic of many solid tumors that has been associated with tumor aggressiveness. Limited diffusion of oxygen generates a gradient of oxygen availability from the blood vessel to the interstitial space and may underlie the recruitment of macrophages fostering cancer progression. However, the available data based on the recruitment of circulating cells to the tumor microenvironment has been so far carried out by conventional co-culture systems which ignore the hypoxic gradient between the vessel to the tumor interstitium. Read More

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http://dx.doi.org/10.3389/fonc.2019.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373430PMC
February 2019

Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics.

Front Pharmacol 2019 6;10:79. Epub 2019 Feb 6.

Institute for Experimental Molecular Imaging, University Clinic, RWTH Aachen University, Aachen, Germany.

The retention and cellular internalization of drug delivery systems and theranostics for cancer therapy can be improved by targeting molecules. Since an increased uptake of riboflavin was reported for various cancers, riboflavin and its derivatives may be promising binding moieties to trigger internalization via the riboflavin transporters (RFVT) 1, 2, and 3. Riboflavin is a vitamin with pivotal role in energy metabolism and indispensable for cellular growth. Read More

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http://dx.doi.org/10.3389/fphar.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372557PMC
February 2019

Sacituzumab Govitecan-hziy in Refractory Metastatic Triple-Negative Breast Cancer.

N Engl J Med 2019 02;380(8):741-751

From the Massachusetts General Hospital Cancer Center (A.B., S.J.I.) and Dana-Farber Cancer Institute (S.M.T.), Harvard Medical School, Boston; Vanderbilt-Ingram Cancer Center, Nashville (I.A.M., V.G.A.); Weill Cornell Medical College (L.T.V.) and New York-Presbyterian-Columbia University Irving Medical Center (K.K.), New York; University of Colorado Cancer Center, Aurora (J.R.D.); Texas Oncology, Baylor University Medical Center, US Oncology, Dallas (J.O.); Orlando Health University of Florida Health Cancer Center, Orlando (R.L.M., N.C.S.); Yale University School of Medicine, New Haven, CT (A.D.S.); University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (H.S.R.); Immunomedics, Morris Plains, NJ (D.M.G., R.I., S.W., R.M.S., W.A.W.); and AIS Consulting, Ann Arbor, MI (A.M.S.).

Background: Standard chemotherapy is associated with low response rates and short progression-free survival among patients with pretreated metastatic triple-negative breast cancer. Sacituzumab govitecan-hziy is an antibody-drug conjugate that combines a humanized monoclonal antibody, which targets the human trophoblast cell-surface antigen 2 (Trop-2), with SN-38, which is conjugated to the antibody by a cleavable linker. Sacituzumab govitecan-hziy enables delivery of high concentrations of SN-38 to tumors. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1814213
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http://dx.doi.org/10.1056/NEJMoa1814213DOI Listing
February 2019
3 Reads

Factors affecting tamoxifen metabolism in breast cancer patients; preliminary results of the French PHACS study (NCT01127295).

Clin Pharmacol Ther 2019 Feb 20. Epub 2019 Feb 20.

Cancer Research Center of Toulouse (CRCT), Inserm U1037, Université Paul Sabatier, Toulouse, France.

In addition to the effect of CYP2D6 genetic polymorphisms, the metabolism of tamoxifen may be impacted by other factors with possible consequences on therapeutic outcome (efficacy, toxicity). This analysis focused on the pharmacokinetic-pharmacogenetic evaluation of tamoxifen in 730 adjuvant breast cancer patients included in a prospective multicenter study. Plasma concentrations of tamoxifen and six major metabolites, the genotype for 63 single nucleotide polymorphisms and co-medications were obtained 6 months after treatment initiation. Read More

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http://doi.wiley.com/10.1002/cpt.1404
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http://dx.doi.org/10.1002/cpt.1404DOI Listing
February 2019
2 Reads

Novel 2,4-disubstituted quinazolines as cytotoxic agents and JAK2 inhibitors: Synthesis, in vitro evaluation and molecular dynamics studies.

Comput Biol Chem 2019 Jan 21;79:110-118. Epub 2019 Jan 21.

Centre for Molecular Cancer Research (CMCR), Vishnu Institute of Pharmaceutical and Educational Research, Narsapur, India. Electronic address:

Recent studies reported the involvement of JAK2/STAT3 pathway in various solid tumours including breast, ovarian, prostate and lung cancers. Clinical literature also reported the lowered burden in breast and ovarian cancers by targeting JAK2 pathway. In this study, a series of novel 2,4-disubstituted quinazolines (2a-2 j and 3a-3 j) were synthesized and were evaluated for their cytotoxicity against human breast cancer (MDA-MB-231) and ovarian cancer (SK-O-V3) cell lines using MTT assay. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2019.01.008DOI Listing
January 2019

Synthesis, in vitro and in vivo biological evaluation of substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones as new potent anticancer agents.

Eur J Med Chem 2019 Jan 26;166:514-530. Epub 2019 Jan 26.

Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Università di Padova, 35128, Padova, Italy. Electronic address:

A small library of 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones has been synthesized and screened according to protocols available at the National Cancer Institute (NCI). Some derivatives were potent antiproliferative agents, showing GI values in the nanomolar range. Remarkably, when most active compounds against leukemia cells were tested in human peripheral blood lymphocytes from healthy donors, were 100-200 times less cytotoxic. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.049DOI Listing
January 2019
3.447 Impact Factor

Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.

Eur J Med Chem 2019 Feb 12;167:485-498. Epub 2019 Feb 12.

State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China. Electronic address:

A series of novel B and C-rings truncated deguelin derivatives have been designed and synthesized in the present study as heat shock protein 90 (Hsp90) inhibitors. The synthesized compounds exhibited micromolar antiproliferative potency toward a panel of human cancer cell lines. Their structure-activity relationships (SARs) were investigated in a systematic manner. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.014DOI Listing
February 2019

The impact of EndoPredict on decision making with increasing oncological work experience: can overtreatment be avoided?

Arch Gynecol Obstet 2019 Feb 19. Epub 2019 Feb 19.

Breast Cancer Center, Municipal Hospital Holweide, Cologne, Germany.

Background: Estimating distant recurrence risk in women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer is still challenging. EndoPredict is a gene expression-based test predicting the likelihood of recurrent disease. We analyzed the difference in oncological decision making with and without the knowledge of gene expression tests. Read More

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http://dx.doi.org/10.1007/s00404-019-05097-wDOI Listing
February 2019

Evaluation of distant sequelae of breast cancer treatment among patients after breast-conserving surgery depending on the type of intervention in the axillary fossa.

Contemp Oncol (Pozn) 2018 31;22(4):240-246. Epub 2018 Dec 31.

Department of Rehabilitation, Ludwik Rydygier's Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland.

Aim Of The Study: The goal of this work was to assess upper-limb sequelae among patients undergoing breast-conserving therapy (BCT) for breast cancer 5-6 years after the surgical procedure.

Material And Methods: A controlled clinical study was conducted on 128 patients who had undergone surgery 5-6 years prior. BCT + ALND (axillary lymph node dissection) was performed in 58 patients and 69 underwent BCT + SLND (sentinel lymph node dissection). Read More

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http://dx.doi.org/10.5114/wo.2018.82643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377421PMC
December 2018

Online tool for monitoring adverse events in patients with cancer during treatment (eRAPID): field testing in a clinical setting.

BMJ Open 2019 Feb 1;9(1):e025185. Epub 2019 Feb 1.

Section of Patient Centred Outcomes Research, Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.

Objectives: Electronic patient self-Reporting of Adverse-events: Patient Information and aDvice (eRAPID) is an online system developed to support patient care during cancer treatment by improving the detection and management of treatment-related symptoms. Patients can complete symptom reports from home and receive severity-based self-management advice, including notifications to contact the hospital for severe symptoms. Patient data are available in electronic records for staff to review. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025185DOI Listing
February 2019

Predicting response: identifying molecular determinants of endocrine response and resistance in breast cancer.

Authors:
Alison J Butt

Expert Rev Endocrinol Metab 2011 Sep;6(5):661-663

a Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia and St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, New South Wales 2052, Australia.

Evaluation of: Fernandez-Cuesta L, Anaganti S, Hainaut P, Olivier M. p53 status influences response to tamoxifen but not to fulvestrant in breast cancer cell lines. Int. Read More

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http://dx.doi.org/10.1586/eem.11.53DOI Listing
September 2011

Gynecomastia: incidence, causes and treatment.

Expert Rev Endocrinol Metab 2011 Sep;6(5):723-730

a Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA.

Gynecomastia is a benign proliferation of glandular tissue of the breast in males. It is common during three phases in the age distribution curve: the neonatal period, puberty and senescence. An imbalance between estrogen and androgen action at the level of breast tissue is believed to be the underlying pathophysiology. Read More

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http://dx.doi.org/10.1586/eem.11.57DOI Listing
September 2011

A Silicon-based Coral-like Nanostructured Microfluidics to Isolate Rare Cells in Human Circulation: Validation by SK-BR-3 Cancer Cell Line and Its Utility in Circulating Fetal Nucleated Red Blood Cells.

Micromachines (Basel) 2019 Feb 17;10(2). Epub 2019 Feb 17.

Department of Genomic Medicine and Center for Medical Genetics, Changhua Christian Hospital; and Department of Genomic Science and Technology, Changhua Christian Hospital Healthcare System, Changhua 50046, Taiwan.

Circulating fetal cells (CFCs) in maternal blood are rare but have a strong potential to be the target for noninvasive prenatal diagnosis (NIPD). "Cell Reveal system" is a silicon-based microfluidic platform capable to capture rare cell populations in human circulation. The platform is recently optimized to enhance the capture efficiency and system automation. Read More

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http://dx.doi.org/10.3390/mi10020132DOI Listing
February 2019

A Review of the Role of Breast Arterial Calcification for Cardiovascular Risk Stratification in Women.

Circulation 2019 Feb;139(8):1094-1101

Division of Cardiovascular Medicine, Department of Medicine, University of California, San Diego.

Cardiovascular disease continues to be the leading cause of death among women in the United States. One of the barriers to improving cardiovascular disease outcomes in women is the lack of reliable, effective screening modalities. Breast arterial calcification has emerged as a potential risk stratification tool. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038092DOI Listing
February 2019
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De-escalated therapy for HR+/HER2+ breast cancer patients with Ki67 response after 2 weeks letrozole: results of the PerELISA neoadjuvant study.

Ann Oncol 2019 Feb 18. Epub 2019 Feb 18.

Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.

Background: In HER2+ breast cancers, neoadjuvant trials of chemotherapy plus anti-HER2 treatment consistently showed lower pathologic complete response (pCR) rates in hormone receptor (HR) positive vs negative tumors. The PerELISA study was aimed to evaluate the efficacy of a de-escalated, chemotherapy-free neoadjuvant regimen in HR+/HER2+ breast cancer patients selected on the basis of Ki67 inhibition after 2-weeks letrozole.

Patients And Methods: PerELISA is a phase II, multicentric study for postmenopausal patients with HR+/HER2+ operable breast cancer. Read More

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http://dx.doi.org/10.1093/annonc/mdz055DOI Listing
February 2019

Whole slide imaging equivalency and efficiency study: experience at a large academic center.

Mod Pathol 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology, Memorial Sloan Kettering, New York, NY, USA.

Whole slide imaging is Food and Drug Administration-approved for primary diagnosis in the United States of America; however, relatively few pathology departments in the country have fully implemented an enterprise wide digital pathology system enabled for primary diagnosis. Digital pathology has significant potential to transform pathology practice with several published studies documenting some level of diagnostic equivalence between digital and conventional systems. However, whole slide imaging also has significant potential to disrupt pathology practice, due to the differences in efficiency of manipulating digital images vis-à-vis glass slides, and studies on the efficiency of actual digital pathology workload are lacking. Read More

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http://dx.doi.org/10.1038/s41379-019-0205-0DOI Listing
February 2019

Development of curcumin-loaded gemini surfactant nanoparticles: Synthesis, characterization and evaluation of anticancer activity against human breast cancer cell lines.

Phytomedicine 2018 Nov 15;57:183-190. Epub 2018 Nov 15.

Department of Biological Sciences, School of Natural Sciences, University of Tabriz, 51555 Tabriz, Iran; Institute of Environment, University of Tabriz, Tabriz, Iran. Electronic address:

Background: Curcumin, the polyphenolic constituent of turmeric, has been recognized as an effective anticancer agent in the treatment of breast cancer. However, the poor bioavailability of curcumin triggers finding of new approaches for elevating its therapeutic efficiency.

Purpose: We aimed to use gemini surfactant nanocarriers for curcumin in order to overcome its limitations. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.017DOI Listing
November 2018
1 Read

Evaluation of screening and risk-reducing surgery for women followed in a high-risk breast/ovarian cancer clinic: it is all about the tubes in BRCA mutation carriers.

Gynecol Oncol Rep 2019 May 1;28:18-22. Epub 2019 Feb 1.

Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Virginia Health System, Charlottesville, VA, USA.

The objectives of this study were to determine both surgical and subsequent cancer outcomes for high-risk women from the University of Virginia's High-Risk Breast/Ovarian Cancer clinic undergoing ovarian cancer risk-reducing surgery. Retrospective review identified high risk women who had ovarian risk reducing surgery over the past decade and surgical outcomes, pathology, pre-operative screening results, and pre-/post-operative cancer diagnoses were evaluated. One hundred and eighty-three high-risk women had risk reducing surgery at a mean age of 50. Read More

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http://dx.doi.org/10.1016/j.gore.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365389PMC
May 2019
1 Read

Design, synthesis, and biologic evaluation of novel chrysin derivatives as cytotoxic agents and caspase-3/7 activators.

Drug Des Devel Ther 2019 22;13:423-433. Epub 2019 Jan 22.

Department of Clinical Pharmacy, College of Pharmacy, Jordan University of Science and Technology, Irbid 22110, Jordan.

Background: Chrysin (5,7-dihydroxyflavone) is a widely distributed natural flavonoid found in many plant extracts, honey and propolis. Several studies revealed that chrysin possesses multiple biological activities including anti-cancer effects. It has been established that activation of apoptosis is the key molecular mechanism responsible for the cytotoxic potential of chrysin. Read More

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http://dx.doi.org/10.2147/DDDT.S189476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349410PMC
January 2019
1 Read

The Needs Self-Rating Questionnaire for Breast Cancer (NSQ-BC): Development of a tool for the needs assessment of women with breast cancer in mainland China.

J Eval Clin Pract 2019 Feb 17. Epub 2019 Feb 17.

School of Nursing, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.

Rationale, Aims, And Objectives: A needs assessment tool considering the cultural background of mainland China has not been reported. This study developed a Needs Self-rating Questionnaire for Breast Cancer (NSQ-BC) based on Maslow's hierarchy of needs for mainland Chinese patients.

Methods: The Delphi technique and pilot cross-sectional surveys (two rounds) were performed for item selection. Read More

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http://dx.doi.org/10.1111/jep.13113DOI Listing
February 2019
1 Read

Palbociclib triggers apoptosis in bladder cancer cells by Cdk2-induced Rad9-mediated reorganization of the Bak.Bcl-xl complex.

Biochem Pharmacol 2019 Feb 14;163:133-141. Epub 2019 Feb 14.

Medical School and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, China. Electronic address:

Palbociclib is a Cdk4/6 inhibitor approved for metastatic estrogen receptor-positive breast cancer. The drug is also under clinical evaluation for metastatic urothelial cancer and other solid tumors. Preclinical studies from multiple tumor types suggest that other factors also affect the sensitivity of individual tumors to Cdk4/6 inhibitor. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.017DOI Listing
February 2019
1 Read

Peptide vaccines in early breast cancer.

Breast 2019 Feb 7;44:128-134. Epub 2019 Feb 7.

IEO, European Institute of Oncology IRCCS, Milan Italy; University of Milan, Italy. Electronic address:

The immune system plays a dual role of host-protecting and tumor-promoting, as elegantly expressed by the 'cancer immunoediting' hypothesis. Although breast cancer has not been traditionally considered to be immunogenic, recently there is accumulating and solid evidence on the association between immune system and breast cancer. To mount an effective anti-tumor response, host immunosurveillance must recognize tumor-specific epitopes, thus defining the antigenicity of a tumor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09609776193002
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http://dx.doi.org/10.1016/j.breast.2019.02.003DOI Listing
February 2019
2 Reads

Synthesis, Spectroscopic Properties, Crystal Structure And Biological Evaluation of New Platinum Complexes with 5-methyl-5- (2-thiomethyl)ethyl Hydantoin.

Anticancer Agents Med Chem 2019 Feb 13. Epub 2019 Feb 13.

Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University of Sofia, Dunav -2 Street, 1000 Sofia. Bulgaria.

Background: The accidental discovery of cisplatin's growth-inhibiting properties a few decades ago led to resurgence of interest in metal-based chemotherapeutics. A number of well-discussed factors such as severe systemic toxicity and unfavourable physicochemical properties further limit the clinical application of the platinating agents. Great efforts have been placed in the development of alternative platinum derivatives with an extended antitumor spectrum and amended toxicity profile as compared to the reference drug cisplatin. Read More

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http://dx.doi.org/10.2174/1871520619666190214103345DOI Listing
February 2019
1 Read

An Uncommon Pairing of common Tumors: Case Report of Ductal Carcinoma Within Fibroadenoma.

Hawaii J Med Public Health 2019 Feb;78(2):39-43

Department of Surgery, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (AM, SS, NF, SW).

Fibroadenomas are common benign tumors of the female breast. In the appropriate clinical setting, they are often managed expectantly without excision. Rarely, cancer may arise within a fibroadenoma, and this diagnosis mandates prompt treatment for malignancy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369888PMC
February 2019

How is patient-centred care addressed in women's health? A theoretical rapid review.

BMJ Open 2019 Feb 13;9(2):e026121. Epub 2019 Feb 13.

Louise Temerty Breast Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.

Purpose: Efforts are needed to reduce gendered inequities and improve health and well-being for women. Patient-centred care (PCC), an approach that informs and engages patients in their own health, is positively associated with improved care delivery, experiences and outcomes. This study aimed to describe how PCC for women (PCCW) has been conceptualised in research. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026121DOI Listing
February 2019
2 Reads

High-Dose Rate Brachyther-apy in the Treatment of Early Stages of Penile Carcinoma.

Klin Onkol 2019 ;32(1):52-57

Background: Interstitial low dose rate brachyther-apy is established organ spar-ing treatment of T1- T2 penile carcinoma. Experience with high-dose rate brachyther-apy is limited in this indication.

Materials And Methods: Twenty-six patients with early penile carcinoma were treated by high-dose rate brachyther-apy at dose 18 × 3 Gy per fraction twice daily between 2002- 2018 at the Department of Oncology and Radiother-apy, University Hospital in Hradec Kralove. Read More

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http://dx.doi.org/10.14735/amko201952DOI Listing
January 2019

Residual Disease after Neoadjuvant Therapy - Developing Drugs for High-Risk Early Breast Cancer.

N Engl J Med 2019 Feb;380(7):612-615

From the Office of Hematology and Oncology Products, Center for Drug Evaluation and Research (T.M.P., J.A.B.), and the Oncology Center of Excellence (R.P.), Food and Drug Administration, Silver Spring, and the Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore (T.M.P., J.A.B.) - both in Maryland.

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http://www.nejm.org/doi/10.1056/NEJMp1900079
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http://dx.doi.org/10.1056/NEJMp1900079DOI Listing
February 2019
1 Read

High-Quality Immunohistochemical Stains through Computational Assay Parameter Optimization.

IEEE Trans Biomed Eng 2019 Feb 13. Epub 2019 Feb 13.

Accurate profiling of tumors using immunohistochemistry (IHC) is essential in cancer diagnosis. The inferences drawn from IHC-stained images depend to a great extent on the quality of immunostaining, which is in turn affected strongly by assay parameters. To optimize assay parameters, the available tissue sample is often limited. Read More

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http://dx.doi.org/10.1109/TBME.2019.2899156DOI Listing
February 2019

What Is the Utility of Routine Complete Blood Count, Liver Function Tests, and Chest X-ray in the Evaluation of Patients with Clinically Node-Negative Breast Cancer?

Am Surg 2019 Jan;85(1):29-33

National Comprehensive Cancer Network guidelines suggest a selective workup of early-stage breast cancer with complete blood count (CBC) and liver function tests (LFTs) and no longer recommend chest X-ray (CXR) to screen for occult metastasis. We evaluated the utility of routine preoperative screening tests in patients with clinically node-negative (cN0) breast cancer. We identified 1611 patients with cN0 breast cancer treated at our institution between October 1998 and December 2015; 94. Read More

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January 2019
1 Read

Exosomes: A Promising Avenue for the Diagnosis of Breast Cancer.

Technol Cancer Res Treat 2019 Jan;18:1533033818821421

1 Central laboratory, Cancer Hospital of China Medical University, Shenyang, China.

Currently, despite the advances in individualized treatment, breast cancer still remains the deadliest form of cancer in women. Diagnostic, prognostic, and therapy-predictive methods are mainly based on the evaluation of tumor tissue samples and are aimed to improve the overall therapeutic level. Therefore, the exploration of a series of circulating biomarkers, which serve as the information source of tumors and could be obtained by peripheral blood samples, represents a high field of interest. Read More

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http://dx.doi.org/10.1177/1533033818821421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373987PMC
January 2019

Two rare cases of endosalpingiosis in the axillary sentinel lymph nodes: evaluation of immunohistochemical staining and one-step nucleic acid amplification (OSNA) assay in patients with breast cancer.

Virchows Arch 2019 Feb 12. Epub 2019 Feb 12.

Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo, 104-0045, Japan.

Benign inclusions, such as endosalpingiosis, in an axillary sentinel lymph node (SLN) can be misdiagnosed as metastatic breast carcinoma. However, endosalpingiosis is rare in lymph nodes above the diaphragm. Among 792 patients with breast carcinoma who underwent sentinel lymph node biopsy at our center, 2 patients have experienced benign glandular inclusions in 3 SLNs, and all of these glandular inclusions were lined with columnar and ciliated epithelial cells. Read More

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http://dx.doi.org/10.1007/s00428-019-02521-zDOI Listing
February 2019

Preventive healthcare-seeking behavior among poor older adults in Mexico: the impact of Seguro Popular, 2000-2012.

Salud Publica Mex 2019 Ene-Feb;61(1):46-53

Department of Health Services, Policy and Practice, Brown University. Providence, Rhode Island, USA.

Objective: Determine the effect of Seguro Popular (SP) on preventive care utilization among low-income SP beneficiaries and uninsured elders in Mexico.

Materials And Methods: Fixed-effects instrumental-variable (FE-IV) pseudo-panel estimation from three rounds of the Mexican National Health and Nutrition Survey (2000, 2006 and 2012).

Results: Our findings suggest that SP has no significant effect on the use of preventive services, including screening for diabetes, hypertension, breast cancer and cervical cancer, by adults aged 50 to 75 years. Read More

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http://dx.doi.org/10.21149/9185DOI Listing
October 2017
1 Read

Ki-67 labeling index as a predictor of response to neoadjuvant chemotherapy in breast cancer.

Jpn J Clin Oncol 2019 Feb 12. Epub 2019 Feb 12.

Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India.

Aims: To investigate Ki-67 index with regard to its ability to predict achievement of pathologic complete response (pCR) to neoadjuvant chemotherapy (NACT) in breast cancer patient.

Material And Methods: It was a prospective observational study, conducted in Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Center (RGCIRC), New Delhi from February 2014 to March 2016. A total of 134 patients with Stage II/III breast cancer who underwent NACT followed by surgery at our center were enrolled and analyzed. Read More

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http://dx.doi.org/10.1093/jjco/hyz012DOI Listing
February 2019

Usefulness of Cytological Scoring Method by Breast Fine Needle Aspiration Cytology on Breast Duct Dilatation and Cystic Lesions.

J Cytol 2019 Jan-Mar;36(1):53-58

Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.

Aim: The objective of this study was to apply a scoring method to fine needle aspiration cytology on breast duct dilatation and cystic lesions, to set an optimum cut-off value to differentiate between benign and malignant cases, and to identify features useful for cell judgment.

Materials And Methods: Samples were 23 preparations of specimens (12 benign and 11 malignant cases) suspected with intraductal lesions or cystic change by ultrasonography or mammography and cytology. The scoring system comprised the following 10 items, and each item was scored 1-3, with a total score of 10-30. Read More

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http://dx.doi.org/10.4103/JOC.JOC_135_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343399PMC
February 2019

In Vitro Evaluation of the Drug Interaction Potential of Doravirine.

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Merck & Co., Inc., Kenilworth, NJ, USA

Doravirine is a novel non-nucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus type 1 infection. studies were conducted to assess the potential for drug interactions with doravirine via major drug-metabolizing enzymes and transporters. Kinetic studies confirmed that cytochrome P450 (CYP) 3A plays a major role in the metabolism of doravirine, with ∼20-fold higher catalytic efficiency for CYP3A4 versus CYP3A5. Read More

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http://dx.doi.org/10.1128/AAC.02492-18DOI Listing
February 2019

Locally advanced breast cancer: Tumor-infiltrating lymphocytes as a predictive factor of response to neoadjuvant chemotherapy.

Eur J Surg Oncol 2019 Feb 4. Epub 2019 Feb 4.

Pathology Department at Luis Razetti Oncology Institute, Caracas, Venezuela.

Objective: To evaluate the pathologic response after neoadjuvant chemotherapy in patients with breast cancer according to the stromal tumor-infiltrating lymphocytes (TILs) as well as the evaluation of overall and disease-free survival according to TILs.

Methods: A six years (2008-2013) review was done including patients with locally advanced breast cancer that received neoadjuvant therapy and then surgery. An evaluation of the percentage of TILs was done in the pretreatment biopsies and a correlation analysis and survival curves were done. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.01.222DOI Listing
February 2019
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Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.

Trends Cardiovasc Med 2019 Jan 29. Epub 2019 Jan 29.

Department of Medicine, Division of Cardiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States; Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States; Department of Biostatistics, Epidemiology & Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States. Electronic address:

Breast cancer is the most common malignancy affecting females, with over 260,000 new cases annually and over 3.1 million survivors in the United States alone. Exposure to potentially cardiotoxic therapies, including anthracyclines, trastuzumab, and radiation therapy, coupled with host factors, place patients at increased risk for the development of cardiovascular disease (CVD) compared to non-cancer controls. Read More

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http://dx.doi.org/10.1016/j.tcm.2019.01.006DOI Listing
January 2019

Socio-Economic Status Inequity in Self Rated Health in Patients with Breast Cancer.

Open Access Maced J Med Sci 2019 Jan 14;7(1):152-156. Epub 2019 Jan 14.

Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: We investigate the evaluation of socio-economic status (SES) inequality on self-rated health (SRH) at women with breast cancer.

Study Design: Cross-sectional study.

Methods: The current study conducted on all 270 breast cancer patients that were admitted to one of the hospitals of Arak University Medical Sciences (Arak, Iran from April to July 2018) by census (using non-random sampling (accessible sampling). Read More

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http://dx.doi.org/10.3889/oamjms.2019.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352461PMC
January 2019

Mortality in Incident Maintenance Dialysis Patients Versus Incident Solid Organ Cancer Patients: A Population-Based Cohort.

Am J Kidney Dis 2019 Jan 28. Epub 2019 Jan 28.

Division of Nephrology, Department of Medicine, University of Ottawa and The Ottawa Hospital, Ottawa, Ontario, Canada; Kidney Research Centre and Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Electronic address:

Rationale & Objective: The mortality rate is high among dialysis patients, but how this compares with other diseases such as cancer is poorly understood. We compared the survival of maintenance dialysis patients with that for patients with common cancers to enhance the understanding of the burden of end-stage kidney disease.

Study Design: Population-based cohort study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02726386183112
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http://dx.doi.org/10.1053/j.ajkd.2018.12.011DOI Listing
January 2019
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Experimental evaluation of seven quality control phantoms for digital breast tomosynthesis.

Phys Med 2019 Jan 9;57:137-144. Epub 2019 Jan 9.

Institut de Radioprotection et de Sûreté Nucléaire, PRP-HOM/SER/Unité d'Expertise en Radioprotection médicale, 31 avenue de la Division Leclerc, BP17, 92262 Fontenay-aux-Roses Cedex, France.

Purposes: The introduction of digital breast tomosynthesis (DBT) into the French breast cancer screening program is forecast by the authorities. The aim of the present study was to evaluate image quality phantoms to be used as internal quality controls.

Methods: Seven breast phantoms dedicated to quality control in mammography were evaluated on reconstructed DBT images: ACR Model 015, BR3D, DBT QC model 021, Mam/Digi-EPQC, MTM100, TOMOMAM® and TOMOPHAN®. Read More

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http://dx.doi.org/10.1016/j.ejmp.2018.12.031DOI Listing
January 2019

Stereotactic radiosurgery with concurrent lapatinib is associated with improved local control for HER2-positive breast cancer brain metastases.

J Neurosurg 2019 Feb 8:1-9. Epub 2019 Feb 8.

Departments of1Radiation Oncology and.

OBJECTIVEWith increasing survival for patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer in the trastuzumab era, there is an increased risk of brain metastasis. Therefore, there is interest in optimizing intracranial disease control. Lapatinib is a small-molecule dual HER2/epidermal growth factor receptor inhibitor that has demonstrated intracranial activity against HER2+ breast cancer brain metastases. Read More

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http://dx.doi.org/10.3171/2018.10.JNS182340DOI Listing
February 2019
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Enhancing magnetic resonance/photoluminescence imaging-guided photodynamic therapy by multiple pathways.

Biomaterials 2019 Apr 2;199:52-62. Epub 2019 Feb 2.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Mitochondria, which are a major source of adenosine triphosphate (ATP) and apoptosis regulators, are the key organelles that promote tumor cell proliferation, and their dysfunction affects tumor cell behavior. Additionally, mitochondria have been shown to play a central role in the biosynthesis of protoporphyrin IX (PpIX), which is a widely used photosensitizer that has been used for tumor detection, monitoring and photodynamic therapy. Nevertheless, photosensitizers administrated exogenously are often restricted by limited bioavailability. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2019.01.044DOI Listing
April 2019
2 Reads

[Evaluation of the therapeutic impact of selected physiotherapy treatments on the treatment of lymphoedema and the assessment of the state of knowledge on risk factors, information acquisition and prophylaxis against women after surgical treatment of breast cancer].

Wiad Lek 2018 ;71(9):1666-1673

Klinika Rehabilitacji Medycznej Uniwersytetu Medycznego w Łodzi, Łódź, Polska.

Objective: Introduction: Breast cancer is a disease with high incidence. In Poland, it is the most common cause of death among cancer in women. A common method of treatment is a breast-saving procedure or its radical removal along with nearby lymph nodes. Read More

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January 2018
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Combined Targeted Therapies for First-line Treatment of Metastatic Triple Negative Breast Cancer-A Phase II Trial of Weekly Nab-Paclitaxel and Bevacizumab Followed by Maintenance Targeted Therapy With Bevacizumab and Erlotinib.

Clin Breast Cancer 2018 Dec 14. Epub 2018 Dec 14.

Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine, Seattle, WA; Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA. Electronic address:

Introduction: Angiogenesis and epidermal growth factor receptor signaling are potential therapeutic targets in triple negative breast cancer (TNBC). We hypothesized that targeting these critical pathways would prolong progression-free survival with first-line therapy for metastatic TNBC.

Patients And Methods: We conducted a phase II trial of nab-paclitaxel and bevacizumab, followed by maintenance therapy with bevacizumab and erlotinib, for patients with metastatic TNBC. Read More

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http://dx.doi.org/10.1016/j.clbc.2018.12.008DOI Listing
December 2018
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Evaluation of Storage Tubes for Combined Analysis of Circulating Nucleic Acids in Liquid Biopsies.

Int J Mol Sci 2019 Feb 6;20(3). Epub 2019 Feb 6.

Department of Gynecology and Obstetrics, University Hospital of Heidelberg, 69120 Heidelberg, Germany.

In the last decade, circulating nucleic acids such as microRNAs (miRNAs) and cell-free DNA (cfDNA) have become increasingly important in serving as potential novel biomarkers for a variety of human diseases. If cell-free nucleic acids are to become routinely used in diagnostics, the difference in plasma miRNA and cfDNA levels between healthy and diseased subjects must exceed pre-analytical and analytical variability. Until now, few studies have addressed the time limitations of pre-processing or explored the potential use of long-term blood storage tubes, which might need to be implemented in real-life diagnostics. Read More

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http://dx.doi.org/10.3390/ijms20030704DOI Listing
February 2019

Raman spectroscopy for the evaluation of the radiobiological sensitivity of normal human breast cells at different time points after irradiation by a clinical proton beam.

Analyst 2019 Feb 8. Epub 2019 Feb 8.

Dipartimento di Medicina Clinica e Sperimentale, Università di Foggia, 71122 Foggia, Italy. and Istituto Nazionale di Fisica Nucleare - Sezione di Bari, 70126 Bari, Italy.

Among different radiotherapy techniques, proton irradiation is an established and effective method for treatment of several types of cancer, because less healthy tissue is exposed with respect to conventional radiotherapy by photons/electrons. Recently, proton therapy has been proposed for the treatment of breast cancer. In vitro studies of proton irradiated normal human breast cells can provide information about cellular radioresponse, particularly as far as healthy tissue is concerned. Read More

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http://dx.doi.org/10.1039/c8an02155dDOI Listing
February 2019