248 results match your criteria Breast Cancer Dove Med Press[Journal]


Detection of human mammaglobin mRNA in breast cancer cells among Vietnamese women.

Breast Cancer (Dove Med Press) 2019 18;11:143-150. Epub 2019 Mar 18.

Department of Oncology, Thanh Nhan Hospital, Hanoi, Vietnam.

Background: Detecting circulating tumor cells (CTCs) is a promising approach for evaluating the progression of occult metastases as well as the efficacy of treatment therapies among patients with breast cancer. A real-time reverse transcriptase polymerase chain reaction (RT-PCR) technique has been proposed for detecting CTCs due to its high sensitivity. In this study, we aimed to validate the RT-PCR technique for human mammaglobin (hMAM) mRNA detection among Vietnamese women with breast cancer. Read More

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https://www.dovepress.com/detection-of-human-mammaglobin-mrn
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http://dx.doi.org/10.2147/BCTT.S193777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429994PMC
March 2019
1 Read

Nano-curcumin's suppression of breast cancer cells (MCF7) through the inhibition of cyclinD1 expression.

Breast Cancer (Dove Med Press) 2019 13;11:137-142. Epub 2019 Mar 13.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran,

Background: Breast cancer is the leading cause of cancer worldwide. The high expenses associated with chemotherapy as well as its side effects make the management of breast cancer a daunting challenge. The most common overexpressed gene in breast cancer is cyclinD1, which induces cell proliferation. Read More

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http://dx.doi.org/10.2147/BCTT.S195800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420787PMC
March 2019
2 Reads

Targeting stem cells in the realm of drug-resistant breast cancer.

Breast Cancer (Dove Med Press) 2019 7;11:115-135. Epub 2019 Mar 7.

Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India,

Since its first documentation, breast cancer (BC) has been a conundrum that ails millions of women every year. This cancer has been well studied by researchers all over the world, which has improved the patient outcome significantly. There are many diagnostic markers to identify the disease, but early detection and then subclassification of this cancer remain dubious. Read More

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http://dx.doi.org/10.2147/BCTT.S189224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410754PMC

Breast cancer risk in a rapidly aging population: advances and approaches to study the aging tissue microenvironment.

Authors:
Steven J Greco

Breast Cancer (Dove Med Press) 2019 19;11:111-113. Epub 2019 Feb 19.

Department of Medicine, Division of Hematology and Oncology, Rutgers-New Jersey Medical School, Newark, NJ, USA,

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385766PMC
http://dx.doi.org/10.2147/BCTT.S200949DOI Listing
February 2019

The antiestrogenic effects of black cohosh on BRCA1 and steroid receptors in breast cancer cells.

Breast Cancer (Dove Med Press) 2019 19;11:99-110. Epub 2019 Feb 19.

Department of Biomedical Diagnostic and Therapeutic Sciences, School of Health Sciences, Oakland University, Rochester, MI 48309-4476, USA,

Background: Black cohosh (BC) is an herbal remedy often used by women to treat symptoms associated with menopause. Research has shown that the molecular activity of BC is associated with estrogen receptor alpha (ER-α) regulation. Progesterone receptor (PR) expression is found to be consistent with ER expression and mutations in the gene, a tumor-suppressor gene, are known to be responsible for about 40%-45% of hereditary breast cancers. Read More

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https://www.dovepress.com/the-antiestrogenic-effects-of-blac
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http://dx.doi.org/10.2147/BCTT.S181730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385778PMC
February 2019
10 Reads

Thyronamine regulation of TAAR1 expression in breast cancer cells and investigation of its influence on viability and migration.

Breast Cancer (Dove Med Press) 2019 19;11:87-97. Epub 2019 Feb 19.

Breast Center, Department of Gynecology and Obstetrics and CCC Munich, University of Munich (LMU), 81377 Munich, Germany,

Objectives: A correlation exists between breast cancer and thyroid disorders, which are common in elderly women. Thyroid hormones are degraded into trace amines, which can bind to the G-protein-coupled receptor trace amine-associated receptor 1 (TAAR1) and thereby activate it. The transformation of thyroid hormones into trace amines is carried out by the ornithine decarboxylase. Read More

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http://dx.doi.org/10.2147/BCTT.S178721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385785PMC
February 2019
1 Read

Breast cancer prevention in older women: an algorithm to choose an optimal preventive agent.

Breast Cancer (Dove Med Press) 2019 19;11:81-86. Epub 2019 Feb 19.

Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA,

Background: Breast cancer is a significant cause of morbidity and mortality in older women. The current study presents new, comprehensive guidelines for providing chemoprevention to older women.

Objective: The objective of this study was to develop and pilot test a chemopreventive choice algorithm to assess its feasibility for older women at high risk of breast cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S179486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385772PMC
February 2019
2 Reads

Overview of the genetic basis toward early detection of breast cancer.

Breast Cancer (Dove Med Press) 2019 21;11:71-80. Epub 2019 Jan 21.

Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka,

Cancer is a socioeconomical burden in any nation. Out of that, breast cancer is identified as the most common malignancy worldwide among women irrespective of age. As women are an important segment in a community, the weakening of their strength toward the development of a nation is a critical problem in each nation. Read More

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http://dx.doi.org/10.2147/BCTT.S185870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345186PMC
January 2019

Immunotherapy for HER2-positive breast cancer: recent advances and combination therapeutic approaches.

Breast Cancer (Dove Med Press) 2019 17;11:53-69. Epub 2019 Jan 17.

Department of General Surgery and Urology, Faculty of Medicine, Jordan University of Science and Technology (JUST), Irbid, Jordan.

Cancer immunotherapy has evolved dramatically with improved understanding of immune microenvironment and immunosurveillance. The immunogenicity of breast cancer is rather heterogeneous. Specific subtypes of breast cancer such as estrogen receptor (ER)-negative, human EGF receptor 2 (HER2)-positive, and triple-negative breast cancer (TNBC) have shown evidence of immunogenicity based on tumor-immune interactions. Read More

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http://dx.doi.org/10.2147/BCTT.S175360DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340364PMC
January 2019
2 Reads

Efficacy and tolerability of BP-C1 in metastatic breast cancer: a Phase II, randomized, double-blind, and placebo-controlled Thai multi-center study.

Breast Cancer (Dove Med Press) 2019 14;11:43-51. Epub 2019 Jan 14.

Digestive Disease Center, Centre for Epidemiology and Biostatistics, Norwegian University of Life Sciences, Oslo, Norway,

Aims: The aim of this study was to compare the efficacy and tolerability of BP-C1 vs equal-looking placebo in metastatic breast cancer.

Materials And Methods: A randomized, double-blind, placebo-controlled multi-center study with a semicross-over design was performed. Sixteen patients received daily intramuscular injection of 0. Read More

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http://dx.doi.org/10.2147/BCTT.S174298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336026PMC
January 2019
1 Read

Primary systemic therapy in HER2-positive operable breast cancer using trastuzumab and chemotherapy: efficacy data, cardiotoxicity and long-term follow-up in 142 patients diagnosed from 2005 to 2016 at a single institution.

Breast Cancer (Dove Med Press) 2019 27;11:29-42. Epub 2018 Dec 27.

Medical Oncology Department, Breast Unit, A Coruña University Hospital, A Coruña, Spain,

Objective: The aim of this study was to evaluate the efficacy, cardiotoxicity profile and long-term benefits of neoadjuvant therapy in human epidermal growth factor receptor 2-positive operable breast cancer patients.

Patients And Methods: A total of 142 patients diagnosed from 2005 to 2016 were included in the study. The treatment consisted of a sequential regimen of taxanes and anthracyclines plus trastuzumab. Read More

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https://www.dovepress.com/primary-systemic-therapy-in-her2-p
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http://dx.doi.org/10.2147/BCTT.S179750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311333PMC
December 2018
11 Reads

Assessment of breast self-examination practice and its associated factors among female undergraduate students in Addis Ababa University, Addis Ababa, Ethiopia, 2016.

Breast Cancer (Dove Med Press) 2019 28;11:21-28. Epub 2018 Dec 28.

Department of Nursing, Faculty of Health Science, Woldia University, Woldia, Ethiopia,

Background: Breast self-examination (BSE) is a simple, very low-cost, non-invasive early detection method used to detect breast cancer at early stage. It should be done for all women older than 20 years. The aim of this study was to assess BSE practice and associated factors among female undergraduate students in Addis Ababa University, Addis Ababa, Ethiopia. Read More

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https://www.dovepress.com/assessment-of-breast-self-examinat
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http://dx.doi.org/10.2147/BCTT.S189023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312690PMC
December 2018
3 Reads

Axillary web syndrome following breast cancer surgery: symptoms, complications, and management strategies.

Breast Cancer (Dove Med Press) 2019 20;11:13-19. Epub 2018 Dec 20.

University of Minnesota, Masonic Cancer Center, Minneapolis, MN, USA,

Axillary web syndrome (AWS) is a common condition occurring in up to 86% of patients following breast cancer surgery with ipsilateral lymphadenectomy of one or more nodes. AWS presents as a single cord or multiple thin cords in the subcutaneous tissues of the ipsilateral axilla. The cords may extend variable distances "down" the ipsilateral arm and/or chest wall. Read More

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http://dx.doi.org/10.2147/BCTT.S146635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304256PMC
December 2018
1 Read

LXR/RXR pathway signaling associated with triple-negative breast cancer in African American women.

Breast Cancer (Dove Med Press) 2019 20;11:1-12. Epub 2018 Dec 20.

Department of Comparative Pathobiology, Purdue University, West Lafayette, IN, USA,

Background: Triple-negative breast cancer (TNBC) is more prevalent in African and African American (AA) women compared to European American (EA) women. African and AA women diagnosed with TNBC experience high frequencies of metastases and less favorable outcomes. Emerging evidence indicates that this disparity may in fact be the result of the uniquely aggressive biology of African and AA disease. Read More

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http://dx.doi.org/10.2147/BCTT.S185960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304259PMC
December 2018
1 Read

Palliative care: needs of advanced breast cancer patients.

Breast Cancer (Dove Med Press) 2018 3;10:231-243. Epub 2018 Dec 3.

Integrated Oncology and Palliative Medicine Department, Breast Oncology Unit, Shaare Zedek Medical Center, Jerusalem, Israel,

Advanced breast cancer is characterized by many physical manifestations with the potential to undermine the quality of life (most related to the cancer and some to treatments), as well as substantial impact on psychosocial well-being. Patients with advanced breast cancer and their families have complex needs that have to be addressed in order to minimize severe distress and deterioration in the quality of life of patients and their family members. This task requires the full engagement of an interdisciplinary approach to palliative care with strong emphasis on the assessment of needs and anticipated needs, patient expectations, skilled therapeutics, and commitment to continuity of care. Read More

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https://www.dovepress.com/palliative-care-needs-of-advanced-
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http://dx.doi.org/10.2147/BCTT.S160462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284851PMC
December 2018
8 Reads

Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action.

Breast Cancer (Dove Med Press) 2018 29;10:207-217. Epub 2018 Nov 29.

Faculty of Nursing, University of Babylon, Babylon, Iraq.

p53 is a tumor suppressor gene involved in various cellular mechanisms including DNA repair, apoptosis, and cell cycle arrest. More than 50% of human cancers have a mutated nonfunctional p53. Breast cancer (BC) is one of the main causes of cancer-related deaths among females. Read More

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https://www.dovepress.com/role-of-curcumin-in-regulating-p53
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http://dx.doi.org/10.2147/BCTT.S167812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276637PMC
November 2018
5 Reads

A single-nucleotide polymorphism of the beta 2-adrenergic receptor gene can predict pathological complete response to taxane- and platinum-based neoadjuvant chemotherapy in breast cancer.

Breast Cancer (Dove Med Press) 2018 27;10:201-206. Epub 2018 Nov 27.

Department of Breast Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China,

Background: Germline genetic polymorphisms in certain genes are associated with the response to anthracycline- and taxane-based neoadjuvant chemotherapy in breast cancer (BC). This translational study aims to evaluate the potential role of rs1042713 in the beta 2-adrenergic receptor () gene in predicting pathological complete responses (pCRs) to taxane- and platinum-based neoadjuvant chemotherapy in locally advanced breast cancer (LABC).

Materials And Methods: The distribution frequencies of rs1042713 were genotyped in LABC patients who received taxane- and platinum-based neoadjuvant chemotherapy. Read More

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http://dx.doi.org/10.2147/BCTT.S189197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267711PMC
November 2018

Artificial intelligence methods for the diagnosis of breast cancer by image processing: a review.

Breast Cancer (Dove Med Press) 2018 30;10:219-230. Epub 2018 Nov 30.

Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran,

Breast cancer is the most common cancer among women around the world. Despite enormous medical progress, breast cancer has still remained the second leading cause of death worldwide; thus, its early diagnosis has a significant impact on reducing mortality. However, it is often difficult to diagnose breast abnormalities. Read More

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http://dx.doi.org/10.2147/BCTT.S175311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278839PMC
November 2018

Protein expression profile and microRNA expression signature in estrogen receptor-positive and -negative breast cancers: report of two cases.

Breast Cancer (Dove Med Press) 2018 23;10:195-199. Epub 2018 Nov 23.

Department of Breast Surgery, Breast Center, Kameda Medical Center, Chiba, Japan,

Background: Identification of the proteins that are associated with estrogen receptor (ER) status is a first step in selecting drugs against hormone-dependent breast cancer. Recently, the proteins associated with ER status were reported using liquid chromatography and tandem mass spectrometry, and microRNA (miRNA) profiling of breast cancer subtype was demonstrated using real-time-PCR.

Methods: We present herein two cases with differential protein expression and miRNA profiling in ER-positive and -negative breast cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S181652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257358PMC
November 2018
1 Read

Potential clinically useful prognostic biomarkers in triple-negative breast cancer: preliminary results of a retrospective analysis.

Breast Cancer (Dove Med Press) 2018 23;10:177-194. Epub 2018 Nov 23.

University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania,

Background: Triple-negative breast cancer (TNBC) has a poor prognosis, even in its early stages. In the absence of postoperative targeted treatments, intensive adjuvant chemotherapy regimens are proposed. For those favorable histologies, such as apocrine and adenoid cystic carcinoma, which frequently belong to TNBC, aggressive treatments are unnecessary. Read More

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http://dx.doi.org/10.2147/BCTT.S175556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257362PMC
November 2018
2 Reads

Expression of chemerin correlates with a poor prognosis in female breast cancer patients.

Breast Cancer (Dove Med Press) 2018 23;10:169-176. Epub 2018 Oct 23.

Department of Internal Medicine, Deraya University, Minia, Egypt.

Objective: Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. Read More

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https://www.dovepress.com/expression-of-chemerin-correlates-
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http://dx.doi.org/10.2147/BCTT.S178181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207381PMC
October 2018
3 Reads

Intracellular aggregated TRPV1 is associated with lower survival in breast cancer patients.

Breast Cancer (Dove Med Press) 2018 15;10:161-168. Epub 2018 Oct 15.

Laboratorio de Estructura y Función Celular, Escuela de Medicina, Facultad de Medicina, Universidad de Valparaíso, Hontaneda, Valparaíso, Chile,

Background: Breast cancer is a malignant disease that represents an important public health burden. The description of new molecular markers can be important to diagnosis, classification, and treatment. Transient receptor potential vanilloid 1 (TRPV1) polymodal channel is expressed in different neoplastic tissues and cell lines of breast cancer and associated with the regulation of tumor growth, tumor neurogenesis, cancer pain, and malignant progression of cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S170208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197232PMC
October 2018
19 Reads

Psychological symptoms in adult Saudi Arabian cancer patients: prevalence and association with self-rated oral health.

Breast Cancer (Dove Med Press) 2018 3;10:153-159. Epub 2018 Oct 3.

Department of Oncology, King Abdulaziz Medical City for National Guard, Ministry of National Guard, Riyadh, Saudi Arabia.

Background: Although psychological symptoms and oral health status are associated with health management and outcomes among cancer patients, their association has not been assessed in Saudi Arabia. We aimed to assess the symptoms of depression, anxiety, and stress and their association with their oral health status, adjusting for sociodemographic and clinical factors.

Methods: A self-reported study included 375 adult cancer patients who received outpatient healthcare services in the Oncology Department, King Abdulaziz Medical City-Riyadh, Saudi Arabia, between April 1 and August 31, 2017. Read More

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http://dx.doi.org/10.2147/BCTT.S168139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174894PMC
October 2018
1 Read

Hypofractionated radiotherapy after conservative surgery may increase low-intermediate grade late fibrosis in breast cancer patients.

Breast Cancer (Dove Med Press) 2018 3;10:143-151. Epub 2018 Oct 3.

Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Aim: To compare late toxicity after postoperative hypofractionated radiotherapy (RT) and standard fractionated RT in patients with early-stage breast carcinoma.

Methods: This retrospective study included 447 patients (Modulated Accelerated Radiotherapy [MARA-1]: 317 patients, and control group [CG]: 130 patients). In the CG, the whole breast received 50. Read More

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http://dx.doi.org/10.2147/BCTT.S167914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174899PMC
October 2018
1 Read

Anticancer and cardio-protective effects of liposomal doxorubicin in the treatment of breast cancer.

Breast Cancer (Dove Med Press) 2018 11;10:131-141. Epub 2018 Sep 11.

Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL, USA,

Breast cancer (BC) is a highly prevalent disease, accounting for the second highest number of cancer-related mortalities worldwide. The anthracycline doxorubicin (DOX), isolated from var. , is a potent chemotherapeutic drug that is successfully used to treat various forms of liquid and solid tumors and is currently approved to treat BC. Read More

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http://dx.doi.org/10.2147/BCTT.S170239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6138971PMC
September 2018
3 Reads

Single-day HER2neu amplification assessment using chip-based digital PCR in formalin-fixed paraffin-embedded breast carcinoma tissue.

Breast Cancer (Dove Med Press) 2018 23;10:121-129. Epub 2018 Jul 23.

Department of Hematology and Oncology, Lahey Hospital and Medical Center, Burlington, MA, USA.

Introduction: Human epidermal growth factor receptor 2 (HER2) amplification is present in almost 15%-20% of breast cancer tumors, making it an important parameter for testing. The present study was designed to evaluate a chip-based digital PCR (dPCR) system for assessing HER2 amplification from formalin-fixed paraffin-embedded breast carcinoma tissue and to compare this system with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH).

Materials And Methods: A total of 84 breast carcinoma tissue samples were analyzed by IHC, FISH, and chip-based dPCR in a blinded manner. Read More

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http://dx.doi.org/10.2147/BCTT.S161264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061198PMC
July 2018
1 Read

Evaluation of the SnapChat mobile social networking application for breast cancer awareness among Saudi students in the Dammam Region of the Kingdom of Saudi Arabia.

Breast Cancer (Dove Med Press) 2018 12;10:113-119. Epub 2018 Jul 12.

Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia,

Purpose: The main aim of this study was to investigate the feasibility and the effectiveness of the SnapChat social networking mobile application in increasing the awareness of breast cancer among the Saudi female students in the Dammam region of Saudi Arabia.

Patients And Methods: An intervention study was carried out with 200 participants divided among 2 groups: a control group and an intervention group. The control group did not receive any awareness materials, and the intervention group received awareness about breast cancer through SnapChat using videos, texts, and pictures. Read More

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http://dx.doi.org/10.2147/BCTT.S166135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047612PMC

Complexes formed by mutant p53 and their roles in breast cancer.

Breast Cancer (Dove Med Press) 2018 18;10:101-112. Epub 2018 Jun 18.

National Laboratory CIB (LNCIB), AREA Science park, Trieste, Italy.

Breast cancer is the most frequently diagnosed malignancy in women, and mutations in the tumor suppressor p53 are commonly detected in the most aggressive subtypes. The majority of gene alterations are missense substitutions, leading to expression of mutant forms of the p53 protein that are frequently detected at high levels in cancer cells. P53 mutants not only lose the physiological tumor-suppressive activity of the wild-type p53 protein but also acquire novel powerful oncogenic functions, referred to as gain of function, that may actively confer a selective advantage during tumor progression. Read More

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http://dx.doi.org/10.2147/BCTT.S145826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011883PMC
June 2018
2 Reads

Mechanism of metastasis suppression by luteolin in breast cancer.

Authors:
Matthew T Cook

Breast Cancer (Dove Med Press) 2018 12;10:89-100. Epub 2018 Jun 12.

Department of Biology, Washburn University, Topeka, KS, USA.

Metastatic breast cancer is typically an extremely aggressive cancer with poor prognosis. Metastasis requires the orchestration of homeostatic factors and cellular programs, many of which are potential therapeutic targets. Luteolin (2-[3,4-dihydroxyphenyl]-5,7-dihydroxy-4-chromenone), is a naturally occurring flavonoid found in fruits and vegetables that exhibits many anticancer properties. Read More

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http://dx.doi.org/10.2147/BCTT.S144202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003288PMC

Impact of semaphorin expression on prognostic characteristics in breast cancer.

Breast Cancer (Dove Med Press) 2018 31;10:79-88. Epub 2018 May 31.

Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Savitribai Phule Pune University, Pune, India.

Breast cancer is one of the major causes of cancer-related deaths among women worldwide. Aberrant regulation of various growth factors, cytokines, and other proteins and their receptors in cancer cells drives the activation of various oncogenic signaling pathways that lead to cancer progression. Semaphorins are a class of proteins which are differentially expressed in various types of cancer including breast cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S135753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987790PMC
May 2018
3 Reads

Progression-free survival/time to progression as a potential surrogate for overall survival in HR+, HER2- metastatic breast cancer.

Breast Cancer (Dove Med Press) 2018 4;10:69-78. Epub 2018 May 4.

Purple Squirrel Economics, New York, NY.

Background: Several recent randomized controlled trials (RCTs) in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC) have demonstrated significant improvements in progression-free survival (PFS); however, few have reported improvement in overall survival (OS). The surrogacy of PFS or time to progression (TTP) for OS has not been formally investigated in HR+, HER2- MBC.

Methods: A systematic literature review of RCTs in HR+, HER2- MBC was conducted to identify studies that reported both median PFS/TTP and OS. Read More

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http://dx.doi.org/10.2147/BCTT.S162841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942170PMC
May 2018
15 Reads

A combination of p53-activating APR-246 and phosphatidylserine-targeting antibody potently inhibits tumor development in hormone-dependent mutant p53-expressing breast cancer xenografts.

Breast Cancer (Dove Med Press) 2018 22;10:53-67. Epub 2018 Mar 22.

Deparment of Biomedical Sciences and Dalton Cardiovascular Research Center, Columbia, MO, USA.

Background: Between 30 and 40% of human breast cancers express a defective tumor suppressor p53 gene. Wild-type p53 tumor suppressor protein promotes cell-cycle arrest and apoptosis and inhibits vascular endothelial growth factor-dependent angiogenesis, whereas mutant p53 protein (mtp53) lacks these functions, resulting in tumor cell survival and metastasis. Restoration of p53 function is therefore a promising drug-targeted strategy for combating mtp53-expressing breast cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S156285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868596PMC
March 2018
2 Reads

Erratum: Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date [Corrigendum].

Authors:

Breast Cancer (Dove Med Press) 2018 16;10:51. Epub 2018 Mar 16.

[This corrects the article on p. 23 in vol. 10, PMID: 29430197. Read More

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http://dx.doi.org/10.2147/BCTT.S166117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858826PMC
March 2018
13 Reads

Spotlight on triptorelin in the treatment of premenopausal women with early-stage breast cancer.

Breast Cancer (Dove Med Press) 2018 6;10:39-49. Epub 2018 Mar 6.

Division of Medical Oncology, Department of Oncology and Hematology, Azienda Ospedaliero Universitaria Policlinico di Modena, Modena, Italy.

Endocrine treatment represents the cornerstone of endocrine-sensitive premenopausal early breast cancer. The estrogen blockade plays a leading role in the therapeutic management of hormone receptor-positive breast cancer together with surgery, radiotherapy, and selective antiestrogen treatments. For several years, selective estrogen receptor modulators, such as tamoxifen, have represented the mainstay of therapy. Read More

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http://dx.doi.org/10.2147/BCTT.S137508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844254PMC
March 2018
2 Reads

Choosing wisely after publication of level I evidence in breast cancer radiotherapy.

Breast Cancer (Dove Med Press) 2018 9;10:31-37. Epub 2018 Feb 9.

Department of Radiation Oncology.

Background: Recent trials in early-stage breast cancer support hypofractionated whole-breast radiotherapy (WBRT) as part of breast-conserving therapy (BCT). Evidence also suggests that radiotherapy (RT) omission may be reasonable for some patients over 70 years. Among radiation-delivery techniques, intensity-modulated RT (IMRT) is more expensive than 3-dimensional conformal RT (3DCRT). Read More

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http://dx.doi.org/10.2147/BCTT.S153117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810527PMC
February 2018
5 Reads

Profile of buparlisib and its potential in the treatment of breast cancer: evidence to date.

Breast Cancer (Dove Med Press) 2018 30;10:23-29. Epub 2018 Jan 30.

European Institute of Oncology, Milano, Italy.

Alteration of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin signaling pathway is key for the growth and survival of several cancers, including breast cancer. In addition, dysregulation of PI3K signaling may contribute to resistance to several anticancer agents. PI3K inhibitors may, therefore, be effective as antineoplastic therapy. Read More

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http://dx.doi.org/10.2147/BCTT.S134641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796458PMC
January 2018
9 Reads

One-step nucleic acid amplification: the possible value in assessing sentinel lymph node metastasis during mastectomy.

Breast Cancer (Dove Med Press) 2018 25;10:13-21. Epub 2018 Jan 25.

Breast Surgery Unit, Bristol Breast Care Centre, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, UK.

Breast cancer is the most common cancer in women, worldwide, and 1,400 deaths per day are attributed to it. The success of national screening programs has seen breast cancers being diagnosed at an earlier stage. With conservative surgery to the breast demonstrating equivalent long-term outcomes, the last 10 years have seen a growing interest in the safety of less invasive management for the axilla in breast cancer patients. Read More

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http://dx.doi.org/10.2147/BCTT.S113737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790072PMC
January 2018

The effects of black cohosh on the regulation of estrogen receptor (ERα) and progesterone receptor (PR) in breast cancer cells.

Breast Cancer (Dove Med Press) 2018 18;10:1-11. Epub 2018 Jan 18.

Biomedical and Therapeutic Sciences, School of Health Sciences.

The North American plant , also known as black cohosh (BC), is a herb that recently has gained attention for its hormonal effects. As the usage of hormone replacement therapy is declining due to its adverse effects in women with cancer, many are turning to herbal remedies like BC to treat menopausal symptoms. It is crucial to determine whether the effects of BC involve estrogen receptor-alpha (ERα). Read More

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http://dx.doi.org/10.2147/BCTT.S144865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779278PMC
January 2018
5 Reads

Pleomorphic lobular carcinoma: is it more similar to a classic lobular cancer or to a high-grade ductal cancer?

Breast Cancer (Dove Med Press) 2017 8;9:581-586. Epub 2017 Dec 8.

Breast Unit, San Giovanni-Addolorata Hospital, Rome, Italy.

Background: Pleomorphic invasive lobular carcinoma (P-ILC) is an uncommon variety of invasive lobular carcinoma with aggressive clinical features. Little is described in the literature regarding this topic.

Materials And Methods: We reviewed our experiences from 2010 to 2015 and compared 40 patients with P-ILC, 126 patients with classic-ILC (C-ILC) and 574 cases of high-grade invasive ductal carcinoma (HG-IDC). Read More

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https://www.dovepress.com/pleomorphic-lobular-carcinoma-is-i
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http://dx.doi.org/10.2147/BCTT.S145570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726360PMC
December 2017
19 Reads

Recent advances of cyclin-dependent kinases as potential therapeutic targets in HR+/HER2- metastatic breast cancer: a focus on ribociclib.

Breast Cancer (Dove Med Press) 2017 6;9:567-579. Epub 2017 Dec 6.

Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Oromia, Ethiopia.

In normal cell cycle progression, transition of G0/G1 phase to synthesis (S) phase for breast and other cells is regulated by association of cyclin D and cyclin-dependent kinases 4 and 6 (CDK4/6) that leads to phosphorylation of retinoblastoma (Rb) protein. Imbalance of this cyclin D-CDK4/6-inhibitors of CDK4/6-Rb phosphorylation pathway is associated with tumorigenesis of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancers. Despite effective first-line endocrine therapy, HR+/HER2- metastatic breast cancers remain still incurable. Read More

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http://dx.doi.org/10.2147/BCTT.S150540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5726365PMC
December 2017
42 Reads
1 Citation

Effect of statins on breast cancer recurrence and mortality: a review.

Breast Cancer (Dove Med Press) 2017 1;9:559-565. Epub 2017 Dec 1.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center.

Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, are medications that have been used for decades to lower cholesterol and to prevent or treat cardiovascular diseases. Since their approval by the US Food and Drug Administration in the 1980s, other potential uses for statins have been speculated on and explored. Basic science and clinical research suggest that statins are also effective in the management of breast cancer. Read More

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https://www.dovepress.com/effect-of-statins-on-breast-cancer
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http://dx.doi.org/10.2147/BCTT.S148080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5716320PMC
December 2017
3 Reads

Prevention and treatment of acute and chronic radiodermatitis.

Breast Cancer (Dove Med Press) 2017 2;9:551-557. Epub 2017 Nov 2.

Centre Laser International de la Peau, Paris, France.

More than half the number of patients with cancer, who are treated with radiotherapy, will have radiodermatitis at some point during their treatment. Radiodermatitis either occurs early on in the treatment period or appears months or up to several years later. Acute radiodermatitis is a burn injury that varies in severity according to both treatment and inherent patient factors. Read More

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https://www.dovepress.com/prevention-and-treatment-of-acute-
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http://dx.doi.org/10.2147/BCTT.S149752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677297PMC
November 2017
5 Reads

Profiling of gene expression regulated by 17β-estradiol and tamoxifen in estrogen receptor-positive and estrogen receptor-negative human breast cancer cell lines.

Breast Cancer (Dove Med Press) 2017 20;9:537-550. Epub 2017 Sep 20.

School of Biological Sciences, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia.

One area of great importance in breast cancer (BC) research is the study of gene expression regulated by both estrogenic and antiestrogenic agents. Although many studies have been performed in this area, most of them have only addressed the effects of 17β-estradiol (E2) and tamoxifen (TAM) on MCF7 cells. This study aimed to determine the effect of low doses of E2 and TAM on the expression levels of 84 key genes, which are commonly involved in breast carcinogenesis, in four BC cell lines differentially expressing estrogen receptor (ER) α and HER2 (MCF7, T47D, BT474, and SKBR3). Read More

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https://www.dovepress.com/profiling-of-gene-expression-regul
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http://dx.doi.org/10.2147/BCTT.S146247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614746PMC
September 2017
2 Reads

Increased risk of breast cancer in neurofibromatosis type 1: current insights.

Breast Cancer (Dove Med Press) 2017 21;9:531-536. Epub 2017 Aug 21.

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre.

Neurofibromatosis type 1 (NF1) is an autosomal dominant condition caused by mutation/deletion of the gene. The gene product, neurofibromin, is a tumor suppressor which represses the activity of the Ras oncogene. Central nervous system (CNS) tumors have long been associated with NF1, but their association with several other malignancies has been demonstrated. Read More

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http://dx.doi.org/10.2147/BCTT.S111397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573065PMC
August 2017
1 Read

Oncological safety and cosmetic outcomes in oncoplastic breast conservation surgery, a review of the best level of evidence literature.

Breast Cancer (Dove Med Press) 2017 4;9:521-530. Epub 2017 Aug 4.

Department of Surgery, New Victoria Hospital Glasgow.

Oncoplastic breast conservation surgery (OBCS) is increasingly becoming part of routine breast cancer surgical management. OBCS may be viewed as an extension of standard breast conservation surgery for resecting tumors of larger sizes without compromising on cosmetic outcome, or as an alternative to mastectomy. High quality evidence to support the oncological safety and benefits of OBCS is lacking. Read More

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http://dx.doi.org/10.2147/BCTT.S113742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552002PMC
August 2017
1 Read

Discordance of the estrogen receptor and HER-2/neu in breast cancer from primary lesion to first and second metastatic site.

Breast Cancer (Dove Med Press) 2017 2;9:515-520. Epub 2017 Aug 2.

Department of Medicine.

Background: Hormone receptor and HER-2/neu discordance between the primary lesion and first metastasis has been reported. This study was performed to determine further biomarker discordance rates between the first and subsequent metastatic breast cancer lesions.

Methods: We performed a retrospective review of paired biomarkers from primary breast cancers compared to first reported and subsequent metastases from 103 patients with breast cancer. Read More

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http://dx.doi.org/10.2147/BCTT.S137709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546587PMC
August 2017
26 Reads

The ABC7 regimen: a new approach to metastatic breast cancer using seven common drugs to inhibit epithelial-to-mesenchymal transition and augment capecitabine efficacy.

Breast Cancer (Dove Med Press) 2017 11;9:495-514. Epub 2017 Jul 11.

Department of Neurosurgery, Ulm University Hospital, Ulm, Germany.

Breast cancer metastatic to bone has a poor prognosis despite recent advances in our understanding of the biology of both bone and breast cancer. This article presents a new approach, the ABC7 regimen (Adjuvant for Breast Cancer treatment using seven repurposed drugs), to metastatic breast cancer. ABC7 aims to defeat aspects of epithelial-to-mesenchymal transition (EMT) that lead to dissemination of breast cancer to bone. Read More

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http://dx.doi.org/10.2147/BCTT.S139963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5513700PMC
July 2017
25 Reads

Cholesterol biosynthesis inhibitor RO 48-8071 reduces progesterone receptor expression and inhibits progestin-dependent stem cell-like cell growth in hormone-dependent human breast cancer cells.

Breast Cancer (Dove Med Press) 2017 7;9:487-494. Epub 2017 Jul 7.

Department of Biomedical Sciences.

Clinical trials and studies have shown that postmenopausal women undergoing combination hormone replacement therapy containing estrogen and progestin have an increased risk of breast cancer compared with women taking estrogen or placebo alone. Using animal models, we have previously shown that synthetic progestins, including medroxyprogesterone acetate (MPA), which is widely used clinically, accelerate breast cancer tumor growth and promote metastasis. Furthermore, we have found that MPA elevates CD44 protein expression and aldehyde dehydrogenase (ALDH) activity, two markers of cancer stem cells (CSCs), and increases mammosphere formation, another hallmark of stem cells, in hormone-dependent T47-D human breast cancer cells. Read More

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http://dx.doi.org/10.2147/BCTT.S140265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511027PMC

A systematic literature review exploring the prevalence of post-traumatic stress disorder and the role played by stress and traumatic stress in breast cancer diagnosis and trajectory.

Breast Cancer (Dove Med Press) 2017 6;9:473-485. Epub 2017 Jul 6.

Applied Research Division for Cognitive and Psychological Science, European Institute of Oncology.

Stress has been extensively studied as a psychosomatic factor associated with breast cancer. This study aims to review the prevalence of post-traumatic stress disorder (PTSD), its associated risk factors, the role of predicting factors for its early diagnosis/prevention, the implications for co-treatment, and the potential links by which stress could impact cancer risk, by closely examining the literature on breast cancer survivors. The authors systematically reviewed studies published from 2002 to 2016 pertaining to PTSD, breast cancer and PTSD, and breast cancer and stress. Read More

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http://dx.doi.org/10.2147/BCTT.S111101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505536PMC
July 2017
25 Reads

Comparative diagnostic accuracy of 18F-FDG PET/CT for breast cancer recurrence.

Breast Cancer (Dove Med Press) 2017 4;9:461-471. Epub 2017 Jul 4.

Nuclear Medicine Unit, IRCCS AOU San Martino - IST, Genoa, Italy.

In the last decades, in addition to conventional imaging techniques and magnetic resonance imaging (MRI), F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has been shown to be relevant in the detection and management of breast cancer recurrence in doubtful cases in selected groups of patients. While there are no conclusive data indicating that imaging tests, including FDG PET/CT, produce a survival benefit in asymptomatic patients, FDG PET/CT can be useful for identifying the site of relapse when traditional imaging methods are equivocal or conflicting and for identifying or confirming isolated loco-regional relapse or isolated metastatic lesions. The present narrative review deals with the potential role of FDG PET in these clinical settings by comparing its accuracy and impact with conventional imaging modalities such as CT, ultrasound, bone scan, F-sodium fluoride PET/CT (F-NaF PET/CT) as well as MRI. Read More

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http://dx.doi.org/10.2147/BCTT.S111098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503278PMC
July 2017
1 Read