195 results match your criteria Breast Cancer Auckl[Journal]


Corrigendum.

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Breast Cancer (Auckl) 2019 11;13:1178223419834790. Epub 2019 Mar 11.

[This corrects the article DOI: 10.1177/1178223417752677.]. Read More

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http://dx.doi.org/10.1177/1178223419834790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413418PMC

Bio-Field Array: The Influence of Junction Mediating and Regulatory Protein Expression on Cytoskeletal Filament Behavior During Apoptosis in Triple-Negative Breast Cancer.

Authors:
Marcy C Purnell

Breast Cancer (Auckl) 2019 28;13:1178223419830981. Epub 2019 Feb 28.

The Loewenberg College of Nursing, University of Memphis, Memphis, TN, USA.

Introduction: The Bio-Field Array (BFA) is a device that generates a dielectrophoretic electromagnetic field (DEP-EMF) when placed in a hypotonic saline solution and a direct current (dc) of ~3 amperes is applied. Human triple-negative breast cancer (MDA-MB-231 cells) is known to have a high percentage of apoptotic () deficient cells and some patients can have poor outcomes with current treatments.

Objectives: Previously, we reported a strong upregulation of the apoptotic arm of the unfolded protein response, via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), as well as positive annexin staining in this human breast carcinoma, when grown in media prepared with BFA's dc DEP-EMF treated saline. Read More

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http://dx.doi.org/10.1177/1178223419830981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396045PMC
February 2019
3 Reads

Bone Metastasis Prognostic Factors in Breast Cancer.

Breast Cancer (Auckl) 2019 22;13:1178223419830978. Epub 2019 Feb 22.

Information Technology Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Bone is the most common site of metastasis in breast cancer. Prognostic factors for predicting bone metastases in breast cancer are controversial yet. In this study, we investigated clinical factors associated with secondary bone metastasis of breast cancer. Read More

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http://dx.doi.org/10.1177/1178223419830978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388452PMC
February 2019
1 Read

Hematologic Malignancies of the Breast: A Contemporary Series Investigating Incidence, Presentation, Accuracy of Diagnosis on Core Needle Biopsy, and Hormone Receptor Expression.

Breast Cancer (Auckl) 2019 21;13:1178223419830982. Epub 2019 Feb 21.

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Distinguishing breast hematologic malignancies in core needle biopsies from other entities can be challenging. Misclassification as a breast carcinoma could result in inappropriate treatment. The aim of this study was to characterize the types, incidence, and helpful diagnostic features of hematologic malignancies of the breast. Read More

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http://dx.doi.org/10.1177/1178223419830982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385330PMC
February 2019

Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research.

Breast Cancer (Auckl) 2019 19;13:1178223419829072. Epub 2019 Feb 19.

Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research UK Centre, MRC Institute of Genetics & Molecular Medicine, Edinburgh, UK.

Neoadjuvant therapy, where patients receive systemic therapy before surgical removal of the tumour, can downstage tumours allowing breast-conserving surgery, rather than mastectomy. In addition to its impact on surgery, the neoadjuvant setting offers a valuable opportunity to monitor individual tumour response. The effectiveness of standard and/or potential new therapies can be tested in the neoadjuvant pre-surgical setting. Read More

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http://dx.doi.org/10.1177/1178223419829072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381436PMC
February 2019
1 Read

Breast Cancer in Very Young Patients in a Spanish Cohort: Age as an Independent Bad Prognostic Indicator.

Breast Cancer (Auckl) 2019 20;13:1178223419828766. Epub 2019 Feb 20.

Medical Oncology and Hematology Unit, Health Research Institute INCLIVA, Valencia, Spain.

Purpose: Breast cancer (BC) in very young women (BCVY) is more aggressive than in older women. The purpose of this study was to evaluate the relevance of a range of clinico-pathological factors in the prognosis of BCVY patients.

Methods: We retrospectively analyzed 258 patients diagnosed with BCVY at our hospital from 1998 to 2014; the control group comprised 101 older patients with BC. Read More

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http://dx.doi.org/10.1177/1178223419828766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383086PMC
February 2019
2 Reads

Clinical Predictive Factors for the Efficacy of Everolimus in Patients With Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer: A Multicenter Retrospective Cohort Study in Japan.

Breast Cancer (Auckl) 2019 22;13:1178223418825135. Epub 2019 Jan 22.

Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Purpose: To investigate the clinical predictive factors for the efficacy of everolimus (EVE) for advanced/metastatic breast cancer (AMBC).

Methods: Routine practice data of consecutive patients with AMBC who received EVE at 5 institutions in western Japan were retrospectively analyzed in this cohort study (study registration no.: UMIN 000032569). Read More

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http://dx.doi.org/10.1177/1178223418825135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343452PMC
January 2019
2 Reads

Parity Differently Affects the Breast Cancer Specific Survival from Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective Study from Korea.

Breast Cancer (Auckl) 2019 27;13:1178223418825134. Epub 2019 Jan 27.

Department of Surgery, College of Medicine, Dong-A University, Busan, Korea.

Purpose: Multiparity might increase general mortality for women, but has inconclusive in patients with breast cancer. Here, we aim to discover their effect in terms of the breast cancer development hypothesis: from ductal carcinoma in situ to invasive carcinoma.

Methods: We included 37 947 patients from the web-based breast cancer registration program of the Korean Breast Cancer Society and analyzed survivals using multivariate Cox regression analysis and whether the associations of these factors displayed linear trends. Read More

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http://dx.doi.org/10.1177/1178223418825134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350119PMC
January 2019
3 Reads

Real-World Effectiveness of Palbociclib Versus Clinical Trial Results in Patients With Advanced/Metastatic Breast Cancer That Progressed on Previous Endocrine Therapy.

Breast Cancer (Auckl) 2019 10;13:1178223418823238. Epub 2019 Jan 10.

Department of Clinical Pharmacy, St. Antonius Hospital, Utrecht/Nieuwegein, The Netherlands.

Objective: The aim of this study was to assess the real-world effectiveness and tolerability of palbociclib combined with endocrine therapy for the treatment of hormone receptor positive (HR-positive), human epidermal growth factor receptor 2 negative (HER2-negative), advanced/metastatic breast cancer that progressed on previous endocrine therapy, and to compare these results with the outcomes of the PALOMA-3 clinical trial.

Methods: This study was a retrospective observational cohort study including all patients who started with palbociclib in the St. Antonius Hospital between September 1, 2016 and April 1, 2018 for the treatment of HR-positive, HER2-negative advanced/metastatic breast cancer that progressed on previous endocrine therapy. Read More

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http://dx.doi.org/10.1177/1178223418823238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330732PMC
January 2019
1 Read

Alarming Situation of Breast Cancer in Women of Lahore, Pakistan From 1984 to 2018.

Breast Cancer (Auckl) 2018 3;12:1178223418816093. Epub 2018 Dec 3.

Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Pakistan.

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http://dx.doi.org/10.1177/1178223418816093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287290PMC
December 2018

Corrigendum.

Authors:

Breast Cancer (Auckl) 2018 16;12:1178223418806626. Epub 2018 Oct 16.

[This corrects the article on p. 35 in vol. 4, PMID: 20697531. Read More

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http://dx.doi.org/10.1177/1178223418806626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195030PMC
October 2018

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Breast Cancer (Auckl) 2018 24;12:1178223418792247. Epub 2018 Aug 24.

Institute of Biomedicine, University of Turku, Turku, Finland.

Basal-like breast cancer is an aggressive form of breast cancer with limited treatment options. The subgroup can be identified immunohistochemically, by lack of hormone receptor expression combined with expression of basal markers such as CK5/6 and/or epidermal growth factor receptor (EGFR). In vitro, several regulators of the actin cytoskeleton are essential for efficient invasion of basal-like breast cancer cell lines. Read More

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http://dx.doi.org/10.1177/1178223418792247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109849PMC
August 2018
1 Read

The Effect of Perioperative Bevacizumab on Disease-Free and Overall Survival in Locally Advanced HER-2 Negative Breast Cancer: A Meta-Analysis.

Breast Cancer (Auckl) 2018 3;12:1178223418792250. Epub 2018 Aug 3.

Hurley Medical Center, Michigan State University, East Lansing, MI, USA.

Introduction: Multiple trials demonstrated that adding Bevacizumab to the standard neoadjuvant chemotherapy in HER-2 negative breast cancer increases pathological complete response. We conducted this meta-analysis to evaluate that effect on survival.

Methods: We performed a systematic search for randomized trials measuring the effect of adding either neoadjuvant or adjuvant Bevacizumab to the standard chemotherapy on disease-free and overall survival in breast cancer surgical candidates. Read More

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http://journals.sagepub.com/doi/10.1177/1178223418792250
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http://dx.doi.org/10.1177/1178223418792250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077892PMC
August 2018
3 Reads

Epithelial-Mesenchymal Transition Markers in Breast Cancer and Pathological Responseafter Neoadjuvant Chemotherapy.

Breast Cancer (Auckl) 2018 1;12:1178223418788074. Epub 2018 Aug 1.

Department of Hematology-Oncology, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL, USA.

The association between pathologic complete response (pCR) following to neoadjuvant chemotherapy (NAC) and the improved survival in breast cancer has been previously reported. The aim of this study was is to explore the expression of several biomarkers described during epithelial-mesenchymal transition (EMT) and the achievement of pCR in different molecular subtypes of breast cancer. We identified archived pathology tissue from patients with breast cancer who received NAC during the year 2014. Read More

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http://dx.doi.org/10.1177/1178223418788074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071152PMC
August 2018
1 Read

Kdm4c is Recruited to Mitotic Chromosomes and Is Relevant for Chromosomal Stability, Cell Migration and Invasion of Triple Negative Breast Cancer Cells.

Breast Cancer (Auckl) 2018 27;12:1178223418773075. Epub 2018 Jul 27.

Doctorate in Biociences, Center of Biomedical Research Universidad de La Sabana-CIBUS, School of Medicine, Universidad de La Sabana, Chía, Colombia.

Members of the jumonji-containing lysine demethylase protein family have been associated with cancer development, although their specific roles in the evolution of tumor cells remain unknown. This work examines the effects of lysine demethylase 4C (KDM4C) knockdown on the behavior of a triple-negative breast cancer cell line. KDM4C expression was knocked-down by siRNA and analyzed by Western blot and immunofluorescence. Read More

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http://dx.doi.org/10.1177/1178223418773075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073829PMC
July 2018
1 Read

Survival Outcomes of Retreatment with Trastuzumab and Cytotoxic Chemotherapy for HER2-Positive Recurrent Patients With Breast Cancer Who Had Been Treated with Neo/adjuvant Trastuzumab Plus Multidrug Chemotherapy: A Japanese Multicenter Observational Study.

Breast Cancer (Auckl) 2018 5;12:1178223418786243. Epub 2018 Jul 5.

Department of Surgery (Breast Surgery), Graduate School of Medicine Kyoto University, Kyoto, Japan.

Background: There are little data on the usefulness of trastuzumab (TZM) retreatment as the first-line treatment for patients with HER2 (human epidermal growth factor receptor 2)-positive breast cancer recurrence after perioperative treatment with TZM.

Aim: To clarify the outcome and safety of TZM retreatment in patients with recurrent HER2-positive breast cancer.

Method: An observational study was conducted on patients who relapsed after primary systemic therapy with TZM using the central registration system. Read More

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http://dx.doi.org/10.1177/1178223418786243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043925PMC
July 2018
9 Reads

Change in Breast Cancer Screening Knowledge is Associated With Change in Mammogram Intention in Mexican-Origin Women After an Educational Intervention.

Breast Cancer (Auckl) 2018 18;12:1178223418782904. Epub 2018 Jun 18.

Department of Family and Community Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

Purpose: To determine the relationship between breast cancer screening knowledge and intent to receive a mammogram within 6 months in a sample of Mexican-origin women living in El Paso, Texas.

Methods: A total of 489 uninsured Mexican-origin women were assigned to treatment or control and completed surveys at pre- and postintervention. Pre-post associations between breast cancer screening knowledge and intent were tested. Read More

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http://dx.doi.org/10.1177/1178223418782904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024335PMC
June 2018
1 Read

Breast Cancer Immunotherapy: An Update.

Breast Cancer (Auckl) 2018 30;12:1178223418774802. Epub 2018 May 30.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology community's interest in extending the benefits to all cancers including breast cancer. Read More

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http://journals.sagepub.com/doi/10.1177/1178223418774802
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http://dx.doi.org/10.1177/1178223418774802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985550PMC
May 2018
2 Reads

The Payer and Patient Cost Burden of Open Breast Conserving Procedures Following Percutaneous Breast Biopsy.

Breast Cancer (Auckl) 2018 4;12:1178223418777766. Epub 2018 Jun 4.

Medtronic, Medical Affairs, Portsmouth, NH, USA.

Objectives: Percutaneous core-needle biopsy (PCNB) is the standard of care to biopsy and diagnose suspicious breast lesions. Dependent on histology, many patients require additional open procedures for definitive diagnosis and excision. This study estimated the payer and patient out-of-pocket (OOP) costs, and complication risk, among those requiring at least 1 open procedure following PCNB. Read More

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http://dx.doi.org/10.1177/1178223418777766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989052PMC
June 2018
2 Reads

Upper-Extremity Deep Vein Thrombosis in Patients With Breast Cancer With Chest Versus Arm Central Venous Port Catheters.

Breast Cancer (Auckl) 2018 20;12:1178223418771909. Epub 2018 Apr 20.

Division of Medical Oncology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Most of the patients undergoing treatment for cancer require placement of a totally implantable venous access device to facilitate safe delivery of chemotherapy. However, implantable ports also increase the risk of deep vein thrombosis and related complications in this high-risk population. The objective of this study was to assess the incidence of upper-extremity deep vein thrombosis (UEDVT) in patients with breast cancer to determine whether the risk of UEDVT was higher with chest versus arm ports, as well as to determine the importance of previously reported risk factors predisposing to UEDVT in the setting of active cancer. Read More

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http://dx.doi.org/10.1177/1178223418771909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987887PMC
April 2018
21 Reads

Clinicopathologic Features and Radiation Therapy Utilization in Patients with Male Breast Cancer: A National Cancer Database Study.

Breast Cancer (Auckl) 2018 20;12:1178223418770687. Epub 2018 Apr 20.

Department of Radiation Oncology, Peggy and Charles Stephenson Oklahoma Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Male breast cancer (MBC) accounts for approximately 1% of all breast cancers, limiting the data characterizing clinicopathologic features and treatment outcomes in patients with MBC. This paucity of data has led to most of our treatment guidance being extrapolated from patients with female breast cancer (FBC). From 1998 to 2012, data were captured using the National Cancer Database to identify patients with nonmetastatic MBC (n = 23 305) and FBC (n = 2 678 061). Read More

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http://dx.doi.org/10.1177/1178223418770687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987905PMC
April 2018
2 Reads

Roles of Extracellular Vesicles in Metastatic Breast Cancer.

Breast Cancer (Auckl) 2018 25;12:1178223418767666. Epub 2018 Apr 25.

Department of Center Lab, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.

Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. Read More

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http://dx.doi.org/10.1177/1178223418767666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987895PMC
April 2018
3 Reads

Correlation Between Mammographic Breast Density, Breast Tissue Type in Ultrasonography, Fibroglandular Tissue, and Background Parenchymal Enhancement in Magnetic Resonance Imaging.

Breast Cancer (Auckl) 2018 18;12:1178223418771971. Epub 2018 Apr 18.

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Breast cancer is the most common malignancy in the female population, and imaging studies play a critical role for its early detection. Mammographic breast density (MBD) is one of the markers used to predict the risk stratification of breast cancer in patients. We aimed to assess the correlations among MBD, ultrasound breast composition (USBC), fibroglandular tissue (FGT), and the amount of background parenchymal enhancement (BPE) in magnetic resonance imaging, after considering the subjects' menopausal status. Read More

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http://dx.doi.org/10.1177/1178223418771971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912268PMC

Analysis of Trends and Factors in Breast Multiple Primary Malignant Neoplasms.

Breast Cancer (Auckl) 2018 28;12:1178223418759959. Epub 2018 Feb 28.

Department of Oncology, Bogomolets National Medical University, Kyiv, Ukraine.

Background: The study aims to evaluate the current state and tendencies in multiple primary breast cancer incidence, behavior, and treatment in Ukraine.

Methods: A total of 2032 patients who received special treatment at the Department of Breast Tumors and Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 were included in the study. Among them, there were 195 patients with multiple primary malignant neoplasms: 54. Read More

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http://dx.doi.org/10.1177/1178223418759959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843092PMC
February 2018
1 Read

Evaluation of Quantra Hologic Volumetric Computerized Breast Density Software in Comparison With Manual Interpretation in a Diverse Population.

Breast Cancer (Auckl) 2018 22;12:1178223418759296. Epub 2018 Feb 22.

Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Objective: Increased mammographic breast density is a well-established risk factor for breast cancer development, regardless of age or ethnic background. The current gold standard for categorizing breast density consists of a radiologist estimation of percent density according to the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) criteria. This study compares paired qualitative interpretations of breast density on digital mammograms with quantitative measurement of density using Hologic's Food and Drug Administration-approved R2 Quantra volumetric breast density assessment tool. Read More

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http://dx.doi.org/10.1177/1178223418759296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826095PMC
February 2018
12 Reads

Real-World Data on Health-Related Quality of Life Assessment in Patients With Breast Cancer Receiving Subcutaneous Trastuzumab.

Breast Cancer (Auckl) 2018 20;12:1178223418758031. Epub 2018 Feb 20.

Hematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon University General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Trastuzumab, a humanized anti-human epidermal growth factor receptor 2 (anti-HER2) antibody delivered intravenously, has revolutionized the treatment of patients with breast cancer overexpressing HER2 protein. Recently, a newer subcutaneous formulation was shown to have comparable efficacy to the initial intravenous trastuzumab. In this study, we aimed to evaluate the impact of subcutaneous trastuzumab on the health-related quality of life (HRQoL) of patients diagnosed with early or metastatic HER2-overexpressing breast cancer. Read More

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http://dx.doi.org/10.1177/1178223418758031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826003PMC
February 2018
10 Reads

Interest of Supportive and Barrier Protective Skin Care Products in the Daily Prevention and Treatment of Cutaneous Toxicity During Radiotherapy for Breast Cancer.

Breast Cancer (Auckl) 2018 23;12:1178223417752772. Epub 2018 Jan 23.

CHU de Poitiers, Poitiers, France.

Purpose: As many as 50% of patients with cancer develop acute skin reactions to some degree with radiotherapy. Proactive skin care is often recommended to minimise these skin reactions and maintain the integrity of the epidermal barrier; nevertheless, no consensual guidelines are systematically used. This multicentre, observational, prospective study evaluated the tolerability and benefit of supportive and barrier protective skin care products in preventing radiotherapy-induced skin reactions in 253 women initiating radiotherapy (exclusive or adjuvant) for breast cancer. Read More

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http://journals.sagepub.com/doi/10.1177/1178223417752772
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http://dx.doi.org/10.1177/1178223417752772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802618PMC
January 2018
14 Reads

Delays in Breast Cancer Detection and Treatment in Developing Countries.

Breast Cancer (Auckl) 2018 8;12:1178223417752677. Epub 2018 Jan 8.

Department of Hematology and Oncology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.

Breast cancer is the most common cancer in women in both developed and developing countries and the second most common cancer in the world. Developing countries are increasingly adopting a Western lifestyle, such as changes in diet and delayed first childbirth, lower parity, and shorter periods of breastfeeding, which are important determinants of a higher incidence of breast cancer among those regions. Low- and middle-income countries (LMICs) represent most of the countries with the highest mortality rates, ranging from 40% to 60%. Read More

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http://dx.doi.org/10.1177/1178223417752677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802601PMC
January 2018
4 Reads

Suppression of Breast Cancer Cell Proliferation by Selective Single-Domain Antibody for Intracellular STAT3.

Breast Cancer (Auckl) 2018 3;12:1178223417750858. Epub 2018 Jan 3.

IIT Research Institute, Chicago, IL, USA.

Background: The serendipitous discovery of heavy-chain antibodies devoid of light chains in camelids and the subsequent development of VHHs (variable region of camelid heavy chain) have provided a very important tool for research and possibly for therapeutics. In this study, we synthesized single-domain 15-kDa antibody SBT-100 (anti-STAT3 B VHH13) against human STAT3 (signal transducer and activator of transcription) that binds selectively to STAT3 and suppresses the function of phosphorylated STAT3 (p-STAT3).

Methods: Single-chain VHH nanobodies were generated by immunizing camelid with humanized STAT3. Read More

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http://dx.doi.org/10.1177/1178223417750858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802608PMC
January 2018
4 Reads

TRAIL-Induced Apoptosis in TRAIL-Resistant Breast Carcinoma Through Quercetin Cotreatment.

Breast Cancer (Auckl) 2018 15;12:1178223417749855. Epub 2018 Jan 15.

Department of Chemistry, Cleveland State University, Cleveland, OH, USA.

Breast cancer is the most commonly diagnosed cancer in women. There is a continued interest for the development of more efficacious treatment regimens for breast carcinoma. Recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) shows potential as a potent anticancer therapeutic for the treatment of breast cancer, whereas displaying minimal toxicity to normal cells. Read More

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http://dx.doi.org/10.1177/1178223417749855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802616PMC
January 2018

Vitamin D and Breast Cancer: Latest Evidence and Future Steps.

Breast Cancer (Auckl) 2017 20;11:1178223417749816. Epub 2017 Dec 20.

Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, The Hashemite University, Zarqa, Jordan.

Vitamin D (the sunshine vitamin) plays a vital role in calcium homeostasis, skeletal metabolism, and immune, cardiovascular, and reproductive systems' functions. The worldwide prevalence of vitamin D deficiency is approximately 1 billion. Vitamin D deficiency is a serious health problem with numerous health consequences; it is associated with diabetes, rheumatic arthritis, Parkinson, Alzheimer diseases, osteomalacia, osteoporosis, and fractures in adults and cancers. Read More

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http://journals.sagepub.com/doi/10.1177/1178223417749816
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http://dx.doi.org/10.1177/1178223417749816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802611PMC
December 2017
12 Reads

Prognostic Significance of Low Claudin3 Expression in Luminal Breast Cancers.

Breast Cancer (Auckl) 2017 13;11:1178223417745858. Epub 2017 Dec 13.

Department of Pathology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

Aim: To study the prognostic value of immunohistochemically detected low Claudin3 expression in breast cancers.

Methods: This retrospective study included patients with breast cancer who were investigated at our unit from 2006 to 2015. Tissue microarrays were constructed, and immunohistochemical staining was done to assess the Claudin3 expression and to classify breast cancers according to the immunohistochemical surrogates for molecular classification. Read More

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http://dx.doi.org/10.1177/1178223417745858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802694PMC
December 2017
3 Reads

Cognitive Behavioral Therapy for Insomnia, Mindfulness, and Yoga in Patients With Breast Cancer with Sleep Disturbance: A Literature Review.

Breast Cancer (Auckl) 2017 7;11:1178223417745564. Epub 2017 Dec 7.

Sleep Medicine Center, Atlanta Veterans Affairs Health Care System, Decatur, GA, USA.

The number of patients with breast cancer diagnosed with sleep disturbance has grown substantially within the United States over the past 20 years. Meanwhile, there have been significant improvements in the psychological treatment of sleep disturbance in patients with breast cancer. More specifically, cognitive behavioral therapy for insomnia (CBT-I), mindfulness, and yoga have shown to be 3 promising treatments with varying degrees of benefit, supporting data, and inherent limitations. Read More

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http://dx.doi.org/10.1177/1178223417745564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802619PMC
December 2017
4 Reads

Breast Cancer Survivors, Common Markers of Inflammation, and Exercise: A Narrative Review.

Breast Cancer (Auckl) 2017 24;11:1178223417743976. Epub 2017 Nov 24.

Duke Cancer Institute, Department of Medicine, Durham, NC, USA.

Exercise may help positively improve inflammatory marker levels, therefore promoting better outcomes in breast cancer survivors. This narrative review is intended to provide an overview between inflammation and breast cancer, in addition to the effects exercise may have on common inflammatory markers that have been examined in both healthy populations and breast cancer survivors throughout the literature. The inconsistencies and gaps in the literature addressed may be important for future research to further understand the relationship between exercise and inflammation, as well as the underlying biological mechanisms that are responsible for these changes. Read More

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http://dx.doi.org/10.1177/1178223417743976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802700PMC
November 2017

Application of Breast Ultrasound Elastography to Differentiate Intracapsular Collection from Silicone-Induced Granuloma of Breast Implant Capsule Complementarily to Contrast-Enhanced Breast Magnetic Resonance Imaging.

Breast Cancer (Auckl) 2017 2;11:1178223417737994. Epub 2017 Nov 2.

Department of Radiology, Faculdade de Ciências Médicas da Santa Casa de São Paulo, Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.

Background: To determine whether there is correlation between magnetic resonance imaging (MRI) findings and breast elastography to differentiate seroma/hematoma from silicone-induced granuloma of breast implant capsule (SIGBIC).

Methods: Prospective study of 99 patients with breast implants submitted to breast MRI during the period from February 1 to May 1, 2017. Patients who present MRI findings of seroma/hematoma or SIGBIC were submitted to a complementary ultrasound elastography study to evaluate the correlation of the results. Read More

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http://dx.doi.org/10.1177/1178223417737994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673004PMC
November 2017
5 Reads

Adipose-Derived Stem Cells in Novel Approaches to Breast Reconstruction: Their Suitability for Tissue Engineering and Oncological Safety.

Breast Cancer (Auckl) 2017 16;11:1178223417726777. Epub 2017 Aug 16.

Graduate Entry Medical School, University of Limerick, Limerick, Ireland.

Adipose-derived stem cells (ADSCs) are rapidly becoming the gold standard cell source for tissue engineering strategies and hold great potential for novel breast reconstruction strategies. However, their use in patients with breast cancer is controversial and their oncological safety, particularly in relation to local disease recurrence, has been questioned. In vitro, in vivo, and clinical studies using ADSCs report conflicting data on their suitability for adipose tissue regeneration in patients with cancer. Read More

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http://dx.doi.org/10.1177/1178223417726777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562338PMC
August 2017
5 Reads

Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer.

Breast Cancer (Auckl) 2017 25;11:1178223417731565. Epub 2017 Sep 25.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Immunotherapy is revolutionizing cancer care across disciplines. The original success of immune checkpoint blockade in melanoma has already been translated to Food and Drug Administration-approved therapies in a number of other cancers, and a large number of clinical trials are underway in many other disease types, including breast cancer. Here, we review the basic requirements for a successful antitumor immune response, with a focus on the metabolic and physical barriers encountered by lymphocytes entering breast tumors. Read More

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http://dx.doi.org/10.1177/1178223417731565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617083PMC
September 2017
60 Reads

High Tangent Radiation Therapy With Field-in-Field Technique for Breast Cancer.

Breast Cancer (Auckl) 2017 20;11:1178223417731297. Epub 2017 Sep 20.

Department of Radiology, Graduate School of Medicine, Gifu University, Gifu, Japan.

Purpose: We evaluated whether the field-in-field (FIF) technique improves the homogeneity of the target in high tangent radiation therapy (HTRT).

Materials And Methods: This study included 30 patients. In total, 3 HTRT plans were created: 1 with conventional opposed fields (Conv-p), 1 with the FIF technique (FIF-p), and 1 with FIF technique using lung-blocked subfields (FIF-LB-p). Read More

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http://dx.doi.org/10.1177/1178223417731297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613839PMC
September 2017
17 Reads

Long-Term Cause-Specific Mortality After Surgery for Women With Breast Cancer: A 20-Year Follow-Up Study From Surveillance, Epidemiology, and End Results Cancer Registries.

Breast Cancer (Auckl) 2017 1;11:1178223417711429. Epub 2017 Jun 1.

Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.

Background: Research into long-term cause-specific mortality of women diagnosed with breast cancer is important because it allows for the splitting of the population into patients who eventually die from breast cancer and from other causes. The adoption of this approach helps to identify patients with an elevated risk of eventual death from breast cancer.

Objective: The primary aim of this study was to examine the associations between both sociodemographic and clinicopathologic characteristics and the underlying risks of death from breast cancer and from other causes for women diagnosed with breast cancer. Read More

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http://dx.doi.org/10.1177/1178223417711429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459512PMC
June 2017
6 Reads

Visualization of Breast Microcalcifications on Digital Breast Tomosynthesis and 2-Dimensional Digital Mammography Using Specimens.

Breast Cancer (Auckl) 2017 12;11:1178223417703388. Epub 2017 Apr 12.

Department of Radiology, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.

Purpose: The purpose of this study is to compare the visibility of microcalcifications of digital breast tomosynthesis (DBT) and full-field digital mammography (FFDM) using breast specimens.

Materials And Methods: Thirty-one specimens' DBT and FFDM were retrospectively reviewed by four readers.

Results: The image quality of microcalcifications of DBT was rated as superior or equivalent in 71. Read More

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http://dx.doi.org/10.1177/1178223417703388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391988PMC
April 2017
6 Reads

Predicting Adherence to Aromatase Inhibitor Therapy among Breast Cancer Survivors: An Application of the Protection Motivation Theory.

Breast Cancer (Auckl) 2017 2;11:1178223417694520. Epub 2017 Mar 2.

Department of Pharmacy Practice, University of Toledo, Toledo, Ohio, USA.

The purpose of this observational study was to determine if the Protection Motivation Theory could predict and explain adherence to aromatase inhibitor (AI) therapy among breast cancer survivors. Purposive sampling was used to identify 288 survivors who had been prescribed AI therapy. A valid and reliable survey was mailed to survivors. Read More

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http://dx.doi.org/10.1177/1178223417694520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391055PMC
March 2017
12 Reads

Breast Cancer Metastasis to the Axillary Lymph Nodes: Are Changes to the Lymph Node "Soil" Localized or Systemic?

Breast Cancer (Auckl) 2017 10;11:1178223417691246. Epub 2017 Feb 10.

Clinical Breast Care Project, Murtha Cancer Center, Windber, PA, USA.

Metastasis is a multistep process that is not well understood. Colonization of a secondary organ requires specific molecular alterations of the host microenvironment. To determine the temporal and spatial changes associated with metastatic dissemination to the axillary lymph nodes, gene expression profiles were compared between histologically normal lymph nodes from node-positive patients and tumor-free nodes from node-negative patients. Read More

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http://dx.doi.org/10.1177/1178223417691246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391061PMC
February 2017
17 Reads

Inhibition of Phosphodiesterase 5 and Increasing the Level of Cyclic Guanosine 3',5' Monophosphate by Hydroalcoholic C. Koch Extract in Human Breast Cancer Cell Lines MCF-7 and MDA-Mb-468.

Breast Cancer (Auckl) 2017 23;11:1178223417690178. Epub 2017 Feb 23.

Department of Biology, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran.

This study aimed to investigate the effect of hydroalcoholic C. Koch extract (HAWE) on phosphodiesterase 5 (PDE5) gene expression and cyclic guanosine 3',5' monophosphate (cGMP) signaling in the MCF-7 and MDA-Mb-468 cell lines. The effective dose (ED50) of HAWE was examined in both cell lines using a 3-(4,5-dimethylhiazol-2-yl)-2,5-diphenyltetrazolium bromide viability test, and the type of cell death was detected by flow cytometry. Read More

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http://dx.doi.org/10.1177/1178223417690178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391053PMC
February 2017
1 Read

Safety, Efficacy, and Patient Acceptability of Everolimus in the Treatment of Breast Cancer.

Breast Cancer (Auckl) 2016 4;10:239-252. Epub 2017 Jan 4.

Medical Oncology, CHU Sart Tilman Liege, Liege, Belgium.; Liege University, Liege, Belgium.

Everolimus combined with exemestane is an important treatment option for patients suffering from estrogen receptor-positive, human epidermal growth factor receptor 2-negative, advanced breast cancer (ABC) who have been previously treated with a nonsteroidal aromatase inhibitor (NSAI). After presentation of phase III registration trial BOLERO-2, several phase IIIb trials have been started to evaluate this regimen in a more real-world setting. Here, we review the efficacy and safety data published or presented at selected international meetings. Read More

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http://dx.doi.org/10.4137/BCBCR.S12443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214808PMC
January 2017
3 Reads

What You Do Not Know Could Hurt You: What Women Wish Their Doctors Had Told Them About Chemotherapy Side Effects on Memory and Response to Alcohol.

Breast Cancer (Auckl) 2016 20;10:229-238. Epub 2016 Dec 20.

Instructor, Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA.

For many patients, a cancer diagnosis is followed by chemotherapy treatment, which works by attacking cells that are growing and dividing throughout the body. Although cancer cells grow and divide more quickly than healthy cells, both are targets. The loss of healthy cells is associated with side effects, such as memory loss and altered response to a variety of food and drugs. Read More

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http://journals.sagepub.com/doi/10.4137/BCBCR.S38389
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http://dx.doi.org/10.4137/BCBCR.S38389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175587PMC
December 2016
1 Read

Oncological Outcomes and Complications After Volume Replacement Oncoplastic Breast Conservations-The Glasgow Experience.

Breast Cancer (Auckl) 2016 19;10:223-228. Epub 2016 Dec 19.

The New Victoria Infirmary, Glasgow, Scotland, UK.

Introduction: Oncoplastic breast conservation surgery (OBCS) combines the principles of surgical oncology and plastic surgery. OBCS has now become a growing option for the treatment of breast cancer and forms a part of breast-conserving therapy (BCT). We sought to investigate and report our experience in two breast units in Glasgow (Victoria Infirmary and Western Infirmary) on volume replacement OBCS. Read More

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http://dx.doi.org/10.4137/BCBCR.S41017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5170883PMC
December 2016
10 Reads

Clinicopathological Significance of TARBP2, APP, and ZNF395 in Breast Cancer.

Breast Cancer (Auckl) 2016 8;10:211-221. Epub 2016 Dec 8.

Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.

The double-stranded RNA-binding protein TARBP2 has been suggested to act as an upstream regulator of breast cancer metastasis by destabilizing transcripts of the possible metastasis suppressors amyloid precursor protein (APP) and ZNF395. We examined this hypothesis by immunostaining of TARBP2, APP, and ZNF395 in 200 breast cancer specimens using tissue microarrays and analyzed the relationships between expression levels and clinicopathological parameters and prognosis. Increased TARBP2 overexpression was associated with shorter overall survival and disease-free survival, and increased but not reduced APP expression correlated with lower overall survival and disease-free survival. Read More

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http://dx.doi.org/10.4137/BCBCR.S40820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147454PMC
December 2016
6 Reads

The Efficacy of Intraoperative Frozen Section Analysis During Breast-Conserving Surgery for Patients with Ductal Carcinoma In Situ.

Breast Cancer (Auckl) 2016 8;10:205-210. Epub 2016 Dec 8.

Department of General Surgery, Presbyterian Medical Center, Jeonju, Korea.

Introduction: Recently, the incidence of ductal carcinoma in situ (DCIS), a noninvasive breast malignancy, has increased. This has resulted in an increase in the incidence of breast-conserving surgery (BCS). Numerous studies have suggested that intraoperative frozen section analysis (IFSA) could reduce the rate of additional excisions required to obtain adequate resection margins. Read More

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http://dx.doi.org/10.4137/BCBCR.S40868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147452PMC
December 2016
13 Reads

Circulating Phospholipids as Biomarkers of Breast Cancer: A Review.

Breast Cancer (Auckl) 2016 13;10:191-196. Epub 2016 Nov 13.

BCAL Diagnostics Pty Ltd, Sydney, NSW, Australia.; School of Medicine, University of New South Wales, Kensington, NSW, Australia.

Breast cancer is the most common cancer in women and the second leading cause of cancer deaths in women. The key to surviving breast cancer is early detection and treatment. Current technologies rely heavily on imaging of the breast, and although considered the gold standard, they have their limitations. Read More

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http://journals.sagepub.com/doi/10.4137/BCBCR.S40693
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http://dx.doi.org/10.4137/BCBCR.S40693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110222PMC
November 2016
5 Reads

Prophylactic Bilateral Nipple-sparing Mastectomy and a Staged Breast Reconstruction Technique: Preliminary Results.

Breast Cancer (Auckl) 2016 9;10:185-189. Epub 2016 Nov 9.

Multidisciplinary Breast Clinic-Unit of Gynecologic Oncology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium.; Department of Obstetrics and Gynecology, Antwerp University Hospital, University of Antwerp, Antwerpen, Belgium.

More high-risk women with breast cancer are identified using genetic testing at a younger age. These young women often opt for prophylactic surgery. Most patients are reluctant for extra donor-site scars besides infections and necrosis. Read More

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http://dx.doi.org/10.4137/BCBCR.S40033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104285PMC
November 2016
4 Reads