217 results match your criteria Breast Cancer Auckl[Journal]


Clinicopathological, Treatment and Event-Free Survival Characteristics in a Moroccan Population of Triple-Negative Breast Cancer.

Breast Cancer (Auckl) 2020 29;14:1178223420906428. Epub 2020 Apr 29.

Equipe de recherche ONCOGYMA, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat, Morocco.

Introduction: Triple-negative breast cancer (TNBC) is a group of breast carcinoma characterized by the lack of expression of estrogen and progesterone hormone receptors (ER, PgR) and HER2. This form is also characterized by its aggressiveness, a low survival rate, and the absence of targeted therapies. This study was planned to evaluate the clinical features, treatment, and prognosis characteristics of TNBC in a population of Moroccan patients. Read More

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http://dx.doi.org/10.1177/1178223420906428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218339PMC

Association of Tagging Single Nucleotide Polymorphisms With Breast Cancer in a Sample of Colombian Population: A Case Control Study.

Breast Cancer (Auckl) 2020 20;14:1178223420904939. Epub 2020 Apr 20.

Faculty of Medicine, Universidad de la Sabana, Chía, Colombia.

Purpose: Ubiquitin ligase genes can act as oncogenes or tumor suppressor genes. They play a role in various diseases, including development and progression of breast cancer; the objective of this study was to evaluate the association of common variants in the () gene with breast cancer risk in a sample of Colombian population.

Methods: We carried out a case-control study to investigate associations of variants in with breast cancer in women from Colombia. Read More

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http://dx.doi.org/10.1177/1178223420904939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172001PMC

Informational Needs in Patients With Breast Cancer With Lymphedema: Is It Important?

Breast Cancer (Auckl) 2020 23;14:1178223420911033. Epub 2020 Mar 23.

Department of Health Information Technology and Management, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Lymphedema is one of the complications of breast cancer treatment. It has no cure yet and can affect the quality of life. This study aimed to identify and investigate informational needs, preferred delivery methods, and time of receiving information about lymphedema for these patients. Read More

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http://dx.doi.org/10.1177/1178223420911033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092654PMC

Religiosity, Psychological Resilience, and Mental Health Among Breast Cancer Patients in Kingdom of Saudi Arabia.

Breast Cancer (Auckl) 2020 17;14:1178223420903054. Epub 2020 Mar 17.

Department of Business Administration, King Saud University, Riyadh, Saudi Arabia.

Objectives: This study aimed to investigate the correlations of religiosity and psychological resilience with mental health among cancer patients and to examine whether religiosity and psychological resilience can predict mental health.

Method: The sample consisted of 329 patients. Researchers applied Islamic Religiosity Scale, Wagnild and Young Resilience Scale, and the scale of Hospital Anxiety and Depression. Read More

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http://dx.doi.org/10.1177/1178223420903054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081476PMC

Acidic Exopolysaccharide Produced from Marine 3MS 2017 for the Protection and Treatment of Breast Cancer.

Breast Cancer (Auckl) 2020 24;14:1178223420902075. Epub 2020 Jan 24.

Department of Medicinal and Aromatic Plants Research, National Research Centre, Giza, Egypt.

Purpose: This study was planned to investigate the anti-breast-cancer property of acidic exopolysaccharide produced from marine 3MS 2017 (BAEPS) in an animal model, which previously showed in-vitro anti-breast-cancer activity, by studying its potential participation in various targeted mechanisms.

Methods: Mammary carcinoma in female Sprague-Dawley rats, both in prophylactic and in curative designs, was chemically induced using 7,12-dimethylebenz-(a)-anthracene (DMBA). 3MS 2017 anti-breast-cancer property was evaluated by studying its effects on cancer-growth-rate-limiting enzymes (aromatase and Na/K ATPase), sexual hormones (estrogen and progesterone), antioxidant and inflammatory biomarkers (cyclooxygenase-1; COX-1 and cyclooxygenase-2; COX-2). Read More

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http://dx.doi.org/10.1177/1178223420902075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984436PMC
January 2020

Nitric Oxide and S-Nitrosylation in Cancers: Emphasis on Breast Cancer.

Breast Cancer (Auckl) 2020 22;14:1178223419882688. Epub 2020 Jan 22.

Department of Pharmacology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Nitric oxide (NO) is a ubiquitous, endogenously produced, water-soluble signaling molecule playing critical roles in physiological processes. Nitric oxide plays pleiotropic roles in cancer and, depending on its local concentration, may lead to either tumor progression or tumor suppression. Addition of NO group to a cysteine residue within a protein, termed as S-nitrosylation, plays diverse regulatory roles and affects processes such as metabolism, apoptosis, protein phosphorylation, and regulation of transcription factors. Read More

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http://dx.doi.org/10.1177/1178223419882688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977095PMC
January 2020

A Novel Gene Mutation Detected With Breast Cancer in a Vietnamese Family by Targeted Next-Generation Sequencing: A Case Report.

Breast Cancer (Auckl) 2020 17;14:1178223420901555. Epub 2020 Jan 17.

Vietnam National Cancer Hospital, Hanoi, Vietnam.

Hereditary breast cancer is an inherited genetic condition, mainly caused by and gene mutations. These genetic changes can increase the risks of breast and ovarian cancers in women, while prostate and breast cancers in men. Especially, mutations in either or genes take important roles in early-onset breast cancer. Read More

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http://dx.doi.org/10.1177/1178223420901555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970476PMC
January 2020

Linkage Between Obesity Leptin and Breast Cancer.

Breast Cancer (Auckl) 2020 10;14:1178223419898458. Epub 2020 Jan 10.

Department of Clinical Nutrition and Dietetics, Hashemite University, Zarqa, Jordan.

Many cancers might be influenced by obesity, including breast cancer, the leading cause of cancer death among women. Obesity is a complex state associated with multiple physiological and molecular changes capable of modulating the behavior of breast tumor cells and the surrounding microenvironment. This review discussed the inverse association between obesity and breast cancer among premenopausal breast cancer females and the positive association among postmenopausal. Read More

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http://dx.doi.org/10.1177/1178223419898458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956603PMC
January 2020

The Study of Validity and Reliability of the SPOFIA Scale in Patients With Postoperative Breast Cancer.

Breast Cancer (Auckl) 2019 21;13:1178223419883833. Epub 2019 Oct 21.

Nursing Department, Faculty of Health Sciences, Sakarya University, Sakarya, Turkey.

Introduction And Aim: This study investigates the validity and reliability of the Subjective Perception of Post-Operative Functional Impairment of the Arm (SPOFIA) scale in patients with postoperative breast cancer.

Materials And Methods: Research was designed as a methodological type. Required permissions were taken from the ethics committee, relevant institutions, and researchers who developed the SPOFIA scale. Read More

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http://dx.doi.org/10.1177/1178223419883833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804360PMC
October 2019
1 Read

Pertuzumab and Trastuzumab Emtansine for Human Epidermal Growth Factor Receptor-2-Positive Metastatic Breast Cancer: Contemporary Population-Based Outcomes.

Breast Cancer (Auckl) 2019 9;13:1178223419879429. Epub 2019 Oct 9.

Department of Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada.

Background: Real-world outcomes for patients with human epidermal growth factor receptor-2 (HER2)-positive metastatic breast cancer (MBC) treated with pertuzumab in combination with taxane chemotherapy plus trastuzumab (TaxTP) in the first line setting and trastuzumab emtansine (TE) in any line of treatment are lacking.

Methods: Cohorts of patients treated with (1) TaxTP and (2) TE from January 1, 2013 through December 31, 2016 were retrospectively obtained from a population-based database. Cohorts were described according to age, hormone receptor (HR) status, prior systemic therapies, event-free survival (EFS) defined as time from start of treatment to start of next line of treatment or death, and overall survival (OS). Read More

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http://dx.doi.org/10.1177/1178223419879429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785925PMC
October 2019
1 Read

Investigation of Prognostic Factors of Survival in Breast Cancer Using a Frailty Model: A Multicenter Study.

Breast Cancer (Auckl) 2019 29;13:1178223419879112. Epub 2019 Sep 29.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Using data from different health centers can provide more accurate knowledge of the survival prognostic factors and their effect on the patient's survival. In this multicenter study, we aimed to investigate the role of prognostic factors on breast cancer survival with large data set.

Methods: This historical cohort study was carried out using data from 1785 participants with breast cancer. Read More

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http://dx.doi.org/10.1177/1178223419879112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769229PMC
September 2019

The Chemokine Receptor CXCR3 Isoform B Drives Breast Cancer Stem Cells.

Breast Cancer (Auckl) 2019 3;13:1178223419873628. Epub 2019 Oct 3.

University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA.

We are seeking to identify molecular targets that are relevant to breast cancer cells with stem-like properties. There is growing evidence that cancer stem cells (CSCs) are supported by inflammatory mediators expressed in the tumor microenvironment. The chemokine receptor CXCR3 binds the interferon-γ-inducible, ELR-negative CXC chemokines CXCL9, CXCL10, and CXCL11 and malignant cells have co-opted this receptor to promote tumor cell migration and invasion. Read More

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http://dx.doi.org/10.1177/1178223419873628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777055PMC
October 2019

Mobile Mammography Screening as an Opportunity to Increase Access of Rural Women to Breast Cancer Research Studies.

Breast Cancer (Auckl) 2019 23;13:1178223419876296. Epub 2019 Sep 23.

Division of Medical Genetics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Objectives: Rural women are underrepresented in cancer research. We hypothesized that providing access to a research study to rural, medically underserved women who were receiving their breast cancer screening using a mobile mammography unit would increase the representation of rural women in a cancer cohort study.

Design: This study is a cross-sectional study using a cohort of women who have been recruited to a breast cancer study in Arkansas. Read More

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http://dx.doi.org/10.1177/1178223419876296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6757489PMC
September 2019
1 Read

Fast-Track Approach for Breast Reconstructive Surgery in Patients With Breast Cancer.

Breast Cancer (Auckl) 2019 17;13:1178223419876931. Epub 2019 Sep 17.

Oncology Department, Bogomolets National Medical University, Kyiv, Ukraine.

Aim: The aim of this study was to develop and implement the concept of fast-track surgery (FTS) for reconstructive breast surgery in patients with breast cancer (BC) to improve early and long-term results of treatment.

Materials And Methods: The study includes 749 patients with stage 1 to 3 BC. A total of 253 patients with BC got treatment according to FTS program and were included to the core group. Read More

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http://dx.doi.org/10.1177/1178223419876931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749777PMC
September 2019
1 Read

Oncological Risk in Autologous Stem Cell Donation for Novel Tissue-Engineering Approaches to Postmastectomy Breast Regeneration.

Breast Cancer (Auckl) 2019 19;13:1178223419864896. Epub 2019 Sep 19.

Discipline of Surgery, The Lambe Institute for Translational Research, National University of Ireland Galway, Galway, Ireland.

Adipose tissue engineering using adipose-derived stem cells (ADSCs) has emerged as an opportunity to develop novel approaches to postmastectomy breast reconstruction with the potential for an autologous tissue source with a natural appearance and texture. As of yet, the role of ADSCs in breast cancer development and metastasis is not completely understood; therefore, we must consider the oncological safety of employing an autologous source of ADSCs for use in breast regeneration. This study investigated the regenerative properties of ADSCs isolated from breast cancer patients, including those who had received neoadjuvant chemotherapy, and noncancer controls. Read More

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http://dx.doi.org/10.1177/1178223419864896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753512PMC
September 2019
1 Read

Bone-Targeted Agents in Breast Cancer: Do We Now Have All the Answers?

Breast Cancer (Auckl) 2019 18;13:1178223419843501. Epub 2019 Sep 18.

Weston Park Cancer Hospital, Sheffield Teaching Hospitals NHS Trust, UK.

The bone-targeted agents (BTAs), bisphosphonates and denosumab, have an established role in the treatment of metastatic breast cancer bone disease and the prevention of cancer-treatment-induced bone loss. Evidence in support of their ability to improve survival in early breast cancer now indicates that the bisphosphonates are effective in postmenopausal women (naturally or chemically induced), but denosumab does not have similar benefits when added to standard adjuvant therapy. In postmenopausal women with early breast cancer, the choice of BTA may differ depending on the indication for treatment; for fracture prevention in low disease recurrence risk patients, denosumab may be favoured (in comparison with placebo) to maintain bone health, and when disease recurrence prevention is a priority in higher risk patients, bisphosphonates may be favoured. Read More

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http://dx.doi.org/10.1177/1178223419843501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751527PMC
September 2019
2 Reads

Mammaglobin-A, VEGFR3, and Ki67 in Human Breast Cancer Pathology and Five Year Survival.

Breast Cancer (Auckl) 2019 26;13:1178223419858957. Epub 2019 Jun 26.

Department of Surgery, University Hospital of North Tees, Stockton on Tees, UK.

Background/methods: This study determines the co-expression of mammaglobin-A, vascular endothelial growth factor receptor-3 (VEGFR3) and Ki67 by immunohistochemistry (IHC) in tissue samples from 80 patients undergoing breast surgery (cancer or benign disease). The tissue expression was compared with the tumour histopathology and Kaplan Meier 5-year survival analysis was performed.

Results: Positive breast tissue expression was observed in 53% samples for mammaglobin, 41% Ki67 and 65% VEGFR3 with a significant positive correlation between Ki67 and VEGFR3 co-expression. Read More

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http://dx.doi.org/10.1177/1178223419858957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6595648PMC
June 2019
2 Reads

Pro-Apoptotic Effects of Estetrol on Long-Term Estrogen-Deprived Breast Cancer Cells and at Low Doses on Hormone-Sensitive Cells.

Breast Cancer (Auckl) 2019 15;13:1178223419844198. Epub 2019 May 15.

Department of Medicine, Division of Endocrinology & Metabolism, University of Virginia Health Systems, Charlottesville, VA, USA.

Purpose: Postmenopausal women with estrogen receptor-positive breast cancers often respond initially to tamoxifen or aromatase inhibitor therapy. Resistance to these treatments usually develops within 12 to 18 months. Clinical studies have demonstrated that high-dose estrogen can induce regression of these endocrine-resistant tumors. Read More

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http://dx.doi.org/10.1177/1178223419844198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535901PMC
May 2019
13 Reads

A Functional Polymorphism (rs6265, G>A) of Brain-Derived Neurotrophic Factor Gene and Breast Cancer: An Association Study.

Breast Cancer (Auckl) 2019 3;13:1178223419844977. Epub 2019 May 3.

Department of Physiology, University of Karachi, Karachi, Pakistan.

Purpose: The objective of this study was to evaluate the relationship between brain-derived neurotrophic factor (BDNF) gene (Val66Met, rs6265, G>A) polymorphism and breast cancer (BC) among females of Southern Pakistan.

Methods: This case-control study consisted of 300 females (BC cases [n = 100] and controls [n = 200]) with age range of 18 to 45 years. All participants were recruited during January to December 2014 and were screened for depression using Zung depression scale. Read More

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http://dx.doi.org/10.1177/1178223419844977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501468PMC
May 2019
2 Reads

SOX10 Is a Sensitive Marker for Breast and Salivary Gland Adenoid Cystic Carcinoma: Immunohistochemical Characterization of Adenoid Cystic Carcinomas.

Breast Cancer (Auckl) 2019 3;13:1178223419842185. Epub 2019 May 3.

Department of Pathology & Immunology, Barnes-Jewish Hospital, Washington University School of Medicine, St Louis, MO, USA.

Breast adenoid cystic carcinomas (AdCCs) can pose diagnostic difficulty due to their rarity, particularly on limited biopsy material. Given that these tumors are triple-negative breast cancers with favorable prognosis, accurate diagnosis is critical for clinical management. A total of 12 cases of breast AdCCs were studied; 17 age-matched salivary gland AdCCs and 5 metastatic AdCCs (1 breast and 4 salivary gland primaries) were also examined. Read More

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http://dx.doi.org/10.1177/1178223419842185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6501487PMC
May 2019
22 Reads

Trace Element Analysis of Cancerous and Non-cancerous Breast Tissues of African Women in Southwest Nigeria Using Particle-Induced X-ray Emission Technique.

Breast Cancer (Auckl) 2019 17;13:1178223419840694. Epub 2019 Apr 17.

Center for Energy Research and Development, Obafemi Awolowo University, Ile Ife, Nigeria.

In this study, we applied particle-induced X-ray emission (PIXE) spectroscopy to investigate the levels of trace elements in breast tissues and whole blood (cancerous and non-cancerous) of selected African women in Ile-Ife, Southwest Nigeria. Freeze-dried and homogenized specimens obtained through mastectomy from clinically diagnosed patients were made into 11-mm-diameter pellets. The pellets were irradiated with 2. Read More

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http://dx.doi.org/10.1177/1178223419840694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6475852PMC
April 2019
14 Reads

Using the Dermatology Life Quality Index to Assess How Breast Radiodermatitis Affects Patients' Quality of Life.

Breast Cancer (Auckl) 2019 12;13:1178223419835547. Epub 2019 Apr 12.

Division of Nursing Research and Education, City of Hope National Medical Center/Beckman Research Institute, Duarte, CA, USA.

Purpose: The purpose of this study is to report the initial validation process for using the Dermatology Life Quality Index (DLQI) for radiodermatitis of the breast.

Methods: This is an additional analysis of a study designed to report a longitudinal study in skin-related and global quality of life in women with breast radiodermatitis. A total of 40 participants completed the DLQI instrument weekly while receiving external radiotherapy of the female breast. Read More

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http://dx.doi.org/10.1177/1178223419835547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463233PMC
April 2019
5 Reads

Corrigendum.

Authors:

Breast Cancer (Auckl) 2019 11;13:1178223419834790. Epub 2019 Mar 11.

[This corrects the article DOI: 10.1177/1178223417752677.]. Read More

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http://dx.doi.org/10.1177/1178223419834790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413418PMC

Bio-Field Array: The Influence of Junction Mediating and Regulatory Protein Expression on Cytoskeletal Filament Behavior During Apoptosis in Triple-Negative Breast Cancer.

Authors:
Marcy C Purnell

Breast Cancer (Auckl) 2019 28;13:1178223419830981. Epub 2019 Feb 28.

The Loewenberg College of Nursing, University of Memphis, Memphis, TN, USA.

Introduction: The Bio-Field Array (BFA) is a device that generates a dielectrophoretic electromagnetic field (DEP-EMF) when placed in a hypotonic saline solution and a direct current (dc) of ~3 amperes is applied. Human triple-negative breast cancer (MDA-MB-231 cells) is known to have a high percentage of apoptotic () deficient cells and some patients can have poor outcomes with current treatments.

Objectives: Previously, we reported a strong upregulation of the apoptotic arm of the unfolded protein response, via reverse transcription-quantitative polymerase chain reaction (RT-qPCR), as well as positive annexin staining in this human breast carcinoma, when grown in media prepared with BFA's dc DEP-EMF treated saline. Read More

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http://dx.doi.org/10.1177/1178223419830981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396045PMC
February 2019
281 Reads

Bone Metastasis Prognostic Factors in Breast Cancer.

Breast Cancer (Auckl) 2019 22;13:1178223419830978. Epub 2019 Feb 22.

Information Technology Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Bone is the most common site of metastasis in breast cancer. Prognostic factors for predicting bone metastases in breast cancer are controversial yet. In this study, we investigated clinical factors associated with secondary bone metastasis of breast cancer. Read More

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http://dx.doi.org/10.1177/1178223419830978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388452PMC
February 2019
4 Reads

Hematologic Malignancies of the Breast: A Contemporary Series Investigating Incidence, Presentation, Accuracy of Diagnosis on Core Needle Biopsy, and Hormone Receptor Expression.

Breast Cancer (Auckl) 2019 21;13:1178223419830982. Epub 2019 Feb 21.

Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.

Background: Distinguishing breast hematologic malignancies in core needle biopsies from other entities can be challenging. Misclassification as a breast carcinoma could result in inappropriate treatment. The aim of this study was to characterize the types, incidence, and helpful diagnostic features of hematologic malignancies of the breast. Read More

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http://dx.doi.org/10.1177/1178223419830982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385330PMC
February 2019
1 Read

Neoadjuvant Therapy for Breast Cancer as a Model for Translational Research.

Breast Cancer (Auckl) 2019 19;13:1178223419829072. Epub 2019 Feb 19.

Applied Bioinformatics of Cancer, University of Edinburgh Cancer Research UK Centre, MRC Institute of Genetics & Molecular Medicine, Edinburgh, UK.

Neoadjuvant therapy, where patients receive systemic therapy before surgical removal of the tumour, can downstage tumours allowing breast-conserving surgery, rather than mastectomy. In addition to its impact on surgery, the neoadjuvant setting offers a valuable opportunity to monitor individual tumour response. The effectiveness of standard and/or potential new therapies can be tested in the neoadjuvant pre-surgical setting. Read More

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http://dx.doi.org/10.1177/1178223419829072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381436PMC
February 2019
15 Reads

Breast Cancer in Very Young Patients in a Spanish Cohort: Age as an Independent Bad Prognostic Indicator.

Breast Cancer (Auckl) 2019 20;13:1178223419828766. Epub 2019 Feb 20.

Medical Oncology and Hematology Unit, Health Research Institute INCLIVA, Valencia, Spain.

Purpose: Breast cancer (BC) in very young women (BCVY) is more aggressive than in older women. The purpose of this study was to evaluate the relevance of a range of clinico-pathological factors in the prognosis of BCVY patients.

Methods: We retrospectively analyzed 258 patients diagnosed with BCVY at our hospital from 1998 to 2014; the control group comprised 101 older patients with BC. Read More

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http://dx.doi.org/10.1177/1178223419828766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383086PMC
February 2019
4 Reads

Clinical Predictive Factors for the Efficacy of Everolimus in Patients With Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer: A Multicenter Retrospective Cohort Study in Japan.

Breast Cancer (Auckl) 2019 22;13:1178223418825135. Epub 2019 Jan 22.

Department of Breast Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Purpose: To investigate the clinical predictive factors for the efficacy of everolimus (EVE) for advanced/metastatic breast cancer (AMBC).

Methods: Routine practice data of consecutive patients with AMBC who received EVE at 5 institutions in western Japan were retrospectively analyzed in this cohort study (study registration no.: UMIN 000032569). Read More

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http://dx.doi.org/10.1177/1178223418825135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343452PMC
January 2019
2 Reads

Parity Differently Affects the Breast Cancer Specific Survival from Ductal Carcinoma In Situ to Invasive Cancer: A Registry-Based Retrospective Study from Korea.

Breast Cancer (Auckl) 2019 27;13:1178223418825134. Epub 2019 Jan 27.

Department of Surgery, College of Medicine, Dong-A University, Busan, Korea.

Purpose: Multiparity might increase general mortality for women, but has inconclusive in patients with breast cancer. Here, we aim to discover their effect in terms of the breast cancer development hypothesis: from ductal carcinoma in situ to invasive carcinoma.

Methods: We included 37 947 patients from the web-based breast cancer registration program of the Korean Breast Cancer Society and analyzed survivals using multivariate Cox regression analysis and whether the associations of these factors displayed linear trends. Read More

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http://dx.doi.org/10.1177/1178223418825134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350119PMC
January 2019
20 Reads

Real-World Effectiveness of Palbociclib Versus Clinical Trial Results in Patients With Advanced/Metastatic Breast Cancer That Progressed on Previous Endocrine Therapy.

Breast Cancer (Auckl) 2019 10;13:1178223418823238. Epub 2019 Jan 10.

Department of Clinical Pharmacy, St. Antonius Hospital, Utrecht/Nieuwegein, The Netherlands.

Objective: The aim of this study was to assess the real-world effectiveness and tolerability of palbociclib combined with endocrine therapy for the treatment of hormone receptor positive (HR-positive), human epidermal growth factor receptor 2 negative (HER2-negative), advanced/metastatic breast cancer that progressed on previous endocrine therapy, and to compare these results with the outcomes of the PALOMA-3 clinical trial.

Methods: This study was a retrospective observational cohort study including all patients who started with palbociclib in the St. Antonius Hospital between September 1, 2016 and April 1, 2018 for the treatment of HR-positive, HER2-negative advanced/metastatic breast cancer that progressed on previous endocrine therapy. Read More

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http://dx.doi.org/10.1177/1178223418823238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330732PMC
January 2019
2 Reads

Alarming Situation of Breast Cancer in Women of Lahore, Pakistan From 1984 to 2018.

Breast Cancer (Auckl) 2018 3;12:1178223418816093. Epub 2018 Dec 3.

Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Pakistan.

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http://dx.doi.org/10.1177/1178223418816093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287290PMC
December 2018
2 Reads

Corrigendum.

Authors:

Breast Cancer (Auckl) 2018 16;12:1178223418806626. Epub 2018 Oct 16.

[This corrects the article on p. 35 in vol. 4, PMID: 20697531. Read More

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http://dx.doi.org/10.1177/1178223418806626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195030PMC
October 2018
1 Read

Formin Proteins FHOD1 and INF2 in Triple-Negative Breast Cancer: Association With Basal Markers and Functional Activities.

Breast Cancer (Auckl) 2018 24;12:1178223418792247. Epub 2018 Aug 24.

Institute of Biomedicine, University of Turku, Turku, Finland.

Basal-like breast cancer is an aggressive form of breast cancer with limited treatment options. The subgroup can be identified immunohistochemically, by lack of hormone receptor expression combined with expression of basal markers such as CK5/6 and/or epidermal growth factor receptor (EGFR). In vitro, several regulators of the actin cytoskeleton are essential for efficient invasion of basal-like breast cancer cell lines. Read More

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http://dx.doi.org/10.1177/1178223418792247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109849PMC
August 2018
2 Reads

The Effect of Perioperative Bevacizumab on Disease-Free and Overall Survival in Locally Advanced HER-2 Negative Breast Cancer: A Meta-Analysis.

Breast Cancer (Auckl) 2018 3;12:1178223418792250. Epub 2018 Aug 3.

Hurley Medical Center, Michigan State University, East Lansing, MI, USA.

Introduction: Multiple trials demonstrated that adding Bevacizumab to the standard neoadjuvant chemotherapy in HER-2 negative breast cancer increases pathological complete response. We conducted this meta-analysis to evaluate that effect on survival.

Methods: We performed a systematic search for randomized trials measuring the effect of adding either neoadjuvant or adjuvant Bevacizumab to the standard chemotherapy on disease-free and overall survival in breast cancer surgical candidates. Read More

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http://journals.sagepub.com/doi/10.1177/1178223418792250
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http://dx.doi.org/10.1177/1178223418792250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077892PMC
August 2018
5 Reads

Epithelial-Mesenchymal Transition Markers in Breast Cancer and Pathological Responseafter Neoadjuvant Chemotherapy.

Breast Cancer (Auckl) 2018 1;12:1178223418788074. Epub 2018 Aug 1.

Department of Hematology-Oncology, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL, USA.

The association between pathologic complete response (pCR) following to neoadjuvant chemotherapy (NAC) and the improved survival in breast cancer has been previously reported. The aim of this study was is to explore the expression of several biomarkers described during epithelial-mesenchymal transition (EMT) and the achievement of pCR in different molecular subtypes of breast cancer. We identified archived pathology tissue from patients with breast cancer who received NAC during the year 2014. Read More

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http://dx.doi.org/10.1177/1178223418788074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071152PMC
August 2018
17 Reads

Kdm4c is Recruited to Mitotic Chromosomes and Is Relevant for Chromosomal Stability, Cell Migration and Invasion of Triple Negative Breast Cancer Cells.

Breast Cancer (Auckl) 2018 27;12:1178223418773075. Epub 2018 Jul 27.

Doctorate in Biociences, Center of Biomedical Research Universidad de La Sabana-CIBUS, School of Medicine, Universidad de La Sabana, Chía, Colombia.

Members of the jumonji-containing lysine demethylase protein family have been associated with cancer development, although their specific roles in the evolution of tumor cells remain unknown. This work examines the effects of lysine demethylase 4C (KDM4C) knockdown on the behavior of a triple-negative breast cancer cell line. KDM4C expression was knocked-down by siRNA and analyzed by Western blot and immunofluorescence. Read More

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http://dx.doi.org/10.1177/1178223418773075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073829PMC
July 2018
2 Reads

Survival Outcomes of Retreatment with Trastuzumab and Cytotoxic Chemotherapy for HER2-Positive Recurrent Patients With Breast Cancer Who Had Been Treated with Neo/adjuvant Trastuzumab Plus Multidrug Chemotherapy: A Japanese Multicenter Observational Study.

Breast Cancer (Auckl) 2018 5;12:1178223418786243. Epub 2018 Jul 5.

Department of Surgery (Breast Surgery), Graduate School of Medicine Kyoto University, Kyoto, Japan.

Background: There are little data on the usefulness of trastuzumab (TZM) retreatment as the first-line treatment for patients with HER2 (human epidermal growth factor receptor 2)-positive breast cancer recurrence after perioperative treatment with TZM.

Aim: To clarify the outcome and safety of TZM retreatment in patients with recurrent HER2-positive breast cancer.

Method: An observational study was conducted on patients who relapsed after primary systemic therapy with TZM using the central registration system. Read More

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http://dx.doi.org/10.1177/1178223418786243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043925PMC
July 2018
13 Reads

Change in Breast Cancer Screening Knowledge is Associated With Change in Mammogram Intention in Mexican-Origin Women After an Educational Intervention.

Breast Cancer (Auckl) 2018 18;12:1178223418782904. Epub 2018 Jun 18.

Department of Family and Community Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA.

Purpose: To determine the relationship between breast cancer screening knowledge and intent to receive a mammogram within 6 months in a sample of Mexican-origin women living in El Paso, Texas.

Methods: A total of 489 uninsured Mexican-origin women were assigned to treatment or control and completed surveys at pre- and postintervention. Pre-post associations between breast cancer screening knowledge and intent were tested. Read More

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http://dx.doi.org/10.1177/1178223418782904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024335PMC
June 2018
5 Reads

Breast Cancer Immunotherapy: An Update.

Breast Cancer (Auckl) 2018 30;12:1178223418774802. Epub 2018 May 30.

Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

The immune system plays a major role in cancer surveillance. Harnessing its power to treat many cancers is now a reality that has led to cures in hopeless situations where no other solutions were available from traditional anticancer drugs. These spectacular achievements rekindled the oncology community's interest in extending the benefits to all cancers including breast cancer. Read More

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http://journals.sagepub.com/doi/10.1177/1178223418774802
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http://dx.doi.org/10.1177/1178223418774802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985550PMC
May 2018
4 Reads

The Payer and Patient Cost Burden of Open Breast Conserving Procedures Following Percutaneous Breast Biopsy.

Breast Cancer (Auckl) 2018 4;12:1178223418777766. Epub 2018 Jun 4.

Medtronic, Medical Affairs, Portsmouth, NH, USA.

Objectives: Percutaneous core-needle biopsy (PCNB) is the standard of care to biopsy and diagnose suspicious breast lesions. Dependent on histology, many patients require additional open procedures for definitive diagnosis and excision. This study estimated the payer and patient out-of-pocket (OOP) costs, and complication risk, among those requiring at least 1 open procedure following PCNB. Read More

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http://dx.doi.org/10.1177/1178223418777766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989052PMC
June 2018
5 Reads

Upper-Extremity Deep Vein Thrombosis in Patients With Breast Cancer With Chest Versus Arm Central Venous Port Catheters.

Breast Cancer (Auckl) 2018 20;12:1178223418771909. Epub 2018 Apr 20.

Division of Medical Oncology, Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Most of the patients undergoing treatment for cancer require placement of a totally implantable venous access device to facilitate safe delivery of chemotherapy. However, implantable ports also increase the risk of deep vein thrombosis and related complications in this high-risk population. The objective of this study was to assess the incidence of upper-extremity deep vein thrombosis (UEDVT) in patients with breast cancer to determine whether the risk of UEDVT was higher with chest versus arm ports, as well as to determine the importance of previously reported risk factors predisposing to UEDVT in the setting of active cancer. Read More

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http://dx.doi.org/10.1177/1178223418771909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987887PMC
April 2018
44 Reads

Clinicopathologic Features and Radiation Therapy Utilization in Patients with Male Breast Cancer: A National Cancer Database Study.

Breast Cancer (Auckl) 2018 20;12:1178223418770687. Epub 2018 Apr 20.

Department of Radiation Oncology, Peggy and Charles Stephenson Oklahoma Cancer Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

Male breast cancer (MBC) accounts for approximately 1% of all breast cancers, limiting the data characterizing clinicopathologic features and treatment outcomes in patients with MBC. This paucity of data has led to most of our treatment guidance being extrapolated from patients with female breast cancer (FBC). From 1998 to 2012, data were captured using the National Cancer Database to identify patients with nonmetastatic MBC (n = 23 305) and FBC (n = 2 678 061). Read More

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http://dx.doi.org/10.1177/1178223418770687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987905PMC
April 2018
3 Reads

Roles of Extracellular Vesicles in Metastatic Breast Cancer.

Breast Cancer (Auckl) 2018 25;12:1178223418767666. Epub 2018 Apr 25.

Department of Center Lab, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing, China.

Cells can secrete extracellular vesicles (EVs) to communicate with neighboring or distant cells by EVs which are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins, lipids, and nucleic acids. Breast Cancer is the most frequently diagnosed malignancy with more than 1 million new cases each year and ranks the leading cause of cancer mortality in women worldwide. In this review, we will discuss recent progresses of the roles and mechanisms of cancer-derived EVs in metastatic breast cancer, with a special attention on tumor microenvironment construction, progression, and chemo/radiotherapy responses. Read More

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http://dx.doi.org/10.1177/1178223418767666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987895PMC
April 2018
5 Reads

Correlation Between Mammographic Breast Density, Breast Tissue Type in Ultrasonography, Fibroglandular Tissue, and Background Parenchymal Enhancement in Magnetic Resonance Imaging.

Breast Cancer (Auckl) 2018 18;12:1178223418771971. Epub 2018 Apr 18.

Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran.

Objective: Breast cancer is the most common malignancy in the female population, and imaging studies play a critical role for its early detection. Mammographic breast density (MBD) is one of the markers used to predict the risk stratification of breast cancer in patients. We aimed to assess the correlations among MBD, ultrasound breast composition (USBC), fibroglandular tissue (FGT), and the amount of background parenchymal enhancement (BPE) in magnetic resonance imaging, after considering the subjects' menopausal status. Read More

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http://dx.doi.org/10.1177/1178223418771971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912268PMC
April 2018
1 Read

Analysis of Trends and Factors in Breast Multiple Primary Malignant Neoplasms.

Breast Cancer (Auckl) 2018 28;12:1178223418759959. Epub 2018 Feb 28.

Department of Oncology, Bogomolets National Medical University, Kyiv, Ukraine.

Background: The study aims to evaluate the current state and tendencies in multiple primary breast cancer incidence, behavior, and treatment in Ukraine.

Methods: A total of 2032 patients who received special treatment at the Department of Breast Tumors and Reconstructive Surgery of the National Cancer Institute from 2008 to 2015 were included in the study. Among them, there were 195 patients with multiple primary malignant neoplasms: 54. Read More

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http://dx.doi.org/10.1177/1178223418759959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843092PMC
February 2018
2 Reads

Evaluation of Quantra Hologic Volumetric Computerized Breast Density Software in Comparison With Manual Interpretation in a Diverse Population.

Breast Cancer (Auckl) 2018 22;12:1178223418759296. Epub 2018 Feb 22.

Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Objective: Increased mammographic breast density is a well-established risk factor for breast cancer development, regardless of age or ethnic background. The current gold standard for categorizing breast density consists of a radiologist estimation of percent density according to the American College of Radiology (ACR) Breast Imaging Reporting and Data System (BI-RADS) criteria. This study compares paired qualitative interpretations of breast density on digital mammograms with quantitative measurement of density using Hologic's Food and Drug Administration-approved R2 Quantra volumetric breast density assessment tool. Read More

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http://dx.doi.org/10.1177/1178223418759296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826095PMC
February 2018
20 Reads

Real-World Data on Health-Related Quality of Life Assessment in Patients With Breast Cancer Receiving Subcutaneous Trastuzumab.

Breast Cancer (Auckl) 2018 20;12:1178223418758031. Epub 2018 Feb 20.

Hematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon University General Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Purpose: Trastuzumab, a humanized anti-human epidermal growth factor receptor 2 (anti-HER2) antibody delivered intravenously, has revolutionized the treatment of patients with breast cancer overexpressing HER2 protein. Recently, a newer subcutaneous formulation was shown to have comparable efficacy to the initial intravenous trastuzumab. In this study, we aimed to evaluate the impact of subcutaneous trastuzumab on the health-related quality of life (HRQoL) of patients diagnosed with early or metastatic HER2-overexpressing breast cancer. Read More

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http://dx.doi.org/10.1177/1178223418758031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826003PMC
February 2018
19 Reads
1 Citation

Interest of Supportive and Barrier Protective Skin Care Products in the Daily Prevention and Treatment of Cutaneous Toxicity During Radiotherapy for Breast Cancer.

Breast Cancer (Auckl) 2018 23;12:1178223417752772. Epub 2018 Jan 23.

CHU de Poitiers, Poitiers, France.

Purpose: As many as 50% of patients with cancer develop acute skin reactions to some degree with radiotherapy. Proactive skin care is often recommended to minimise these skin reactions and maintain the integrity of the epidermal barrier; nevertheless, no consensual guidelines are systematically used. This multicentre, observational, prospective study evaluated the tolerability and benefit of supportive and barrier protective skin care products in preventing radiotherapy-induced skin reactions in 253 women initiating radiotherapy (exclusive or adjuvant) for breast cancer. Read More

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http://journals.sagepub.com/doi/10.1177/1178223417752772
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http://dx.doi.org/10.1177/1178223417752772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802618PMC
January 2018
18 Reads

Delays in Breast Cancer Detection and Treatment in Developing Countries.

Breast Cancer (Auckl) 2018 8;12:1178223417752677. Epub 2018 Jan 8.

Department of Hematology and Oncology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico.

Breast cancer is the most common cancer in women in both developed and developing countries and the second most common cancer in the world. Developing countries are increasingly adopting a Western lifestyle, such as changes in diet and delayed first childbirth, lower parity, and shorter periods of breastfeeding, which are important determinants of a higher incidence of breast cancer among those regions. Low- and middle-income countries (LMICs) represent most of the countries with the highest mortality rates, ranging from 40% to 60%. Read More

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http://dx.doi.org/10.1177/1178223417752677DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802601PMC
January 2018
5 Reads