4,334 results match your criteria Breast Cancer[Journal]


Comparison between AJCC 8th prognostic stage and UICC anatomical stage in patients with primary breast cancer: a single institutional retrospective study.

Breast Cancer 2020 Jun 3. Epub 2020 Jun 3.

Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.

Background: The 8th edition American Joint Committee on Cancer (AJCC) proposed a prognostic stage (PS), which included not only anatomical factors, but also biological factors. We aimed to investigate the clinicopathological significance of the PS and to compare PS and anatomical stage (AS) that has been established by the Union for International Cancer Control (UICC).

Methods: Between 2002 and 2017, 800 patients were included in the study. Read More

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http://dx.doi.org/10.1007/s12282-020-01115-xDOI Listing

An investigation into socio-demographic-, health-, and cancer-related factors associated with cortisol and C-reactive protein levels in breast cancer survivors: a longitudinal study.

Breast Cancer 2020 Jun 1. Epub 2020 Jun 1.

School of Human Kinetics, University of Ottawa, Montpetit Hall, Room 339, Ottawa, ON, K1N 6N5, Canada.

Background: Breast cancer survivors (BCS) may exhibit dysregulated patterns of cortisol and C-reactive protein (CRP). The aims of this study were to describe BCS' cortisol and CRP levels over a 1-year period after treatment, and assess how levels relate to socio-demographic- (age, education level, marital status), health- (body mass index [BMI] category, menopausal status), and cancer-related factors (cancer stage, chemotherapy exposure, time since diagnosis).

Methods: Participants (N = 201) provided data at 3 months post-treatment (T1) and again 3, 6, 9, and 12 months later (T2-T5). Read More

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http://dx.doi.org/10.1007/s12282-020-01113-zDOI Listing

Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient's perspective.

Breast Cancer 2020 Jun 1. Epub 2020 Jun 1.

Breast Centre Zurich, Seefeldstrasse 214, 8008, Zurich, Switzerland.

Purpose: When ipsilateral breast-tumor recurrence (IBTR) following breast-conserving surgery (BCS) occurs, the cure of a potentially life-threatening disease is the main goal. If, however, this is diagnosed early, prognosis is still good and patient-reported outcomes become more important. Despite the fact that many patients would prefer a further BCS, international breast cancer guidelines still recommend mastectomy, mainly because previous radiation implies limited options. Read More

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http://dx.doi.org/10.1007/s12282-020-01114-yDOI Listing

A Randomized Parallel Controlled Phase II Trial of Recombinant Human Endostatin Added to Neoadjuvant Chemotherapy for Stage III Breast Cancer.

Clin Breast Cancer 2020 Apr 28. Epub 2020 Apr 28.

Breast Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. Electronic address:

Background: To explore the potential advantage of preoperative anti-angiogenosis therapy, we implemented a study to evaluate the efficacy of recombinant human endostatin (EN) in combination with neoadjuvant chemotherapy in the treatment of stage III breast cancer.

Patients And Methods: Eighty-seven patients were randomized to neoadjuvant TEC (docetaxel, epirubicin, and cyclophosphamide) or to EN+TEC, followed by surgery. The primary endpoint was the objective response rate (ORR). Read More

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http://dx.doi.org/10.1016/j.clbc.2020.04.009DOI Listing

Comment on "Combining Adjuvant Radiotherapy With Capecitabine in Chemotherapy-resistant Breast Cancer: Feasibility, Safety, and Toxicity".

Clin Breast Cancer 2020 May 6. Epub 2020 May 6.

Radiation Oncology Unit - Oncology Department, University of Florence - Azienda Ospedaliero Universitaria Careggi, Florence, Italy.

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http://dx.doi.org/10.1016/j.clbc.2020.04.014DOI Listing

The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.

Breast Cancer 2020 May 29. Epub 2020 May 29.

Department of Breast Oncology, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1395, Japan.

Background: The TNM system, which reflects the anatomical extent of disease, was used for stage definition. In the recently published AJCC 8th edition, the new staging system of the clinical and pathological prognostic stage, which incorporates biological factors, is introduced.

Patients And Methods: A total of 2622 patients with primary breast cancer at stage I-III were included in this study. Read More

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http://dx.doi.org/10.1007/s12282-020-01116-wDOI Listing

Targeting of antitumor ımmune responses with live-attenuated Leishmania strains in breast cancer model.

Breast Cancer 2020 May 29. Epub 2020 May 29.

Department of Basic Oncology, Ege University, Institute of Health Sciences, Izmir, Turkey.

Background: Cancer is a major cause of death worldwide and most of the therapeutic approaches are relatively ineffective in eliminating cancer especially due to drug resistance. As an alternative, therapy with live microorganisms can induce a robust proinflammatory and anti-cancer immune response in the microenvironment of the tumor. In the present study, we aimed to establish a model for taking the advantages of immune responses against intracellular protozoan parasites for cancer treatment. Read More

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http://dx.doi.org/10.1007/s12282-020-01112-0DOI Listing

Identification of Luminal Subtypes of Breast Carcinoma Using Surrogate Immunohistochemical Markers and Ascertaining Their Prognostic Relevance.

Clin Breast Cancer 2020 Apr 6. Epub 2020 Apr 6.

Department of Pathology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India. Electronic address:

Background: Therapeutic decisions in breast carcinoma are being made on the basis of tumor cell proliferation using exorbitant genomic tests. The 2013 St Gallen meeting advocated surrogate definitions for classifying tumors into luminal subtypes on the basis of immunohistochemical (IHC) markers. We studied the classification of estrogen receptor (ER)-positive tumors using these definitions as well as different methods for Ki-67 labeling index (LI) estimation. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.012DOI Listing

SNORA71B promotes breast cancer cells across blood-brain barrier by inducing epithelial-mesenchymal transition.

Breast Cancer 2020 May 23. Epub 2020 May 23.

Department of Breast Surgery, The Second Affiliated Hospital of Nanchang University, No.1 Mingde Road, Donghu District, Nanchang, 330006, Jiangxi Province, China.

Background: Brain metastasis (BM) is a dreadful complication that significantly impacts the quality of life in breast cancer patients. A key process during brain metastasis is the migration of cancer cells across blood-brain barrier (BBB). However, the role of snoRNAs regulating BBB in BM is still unknown. Read More

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http://dx.doi.org/10.1007/s12282-020-01111-1DOI Listing

Update on Partial Breast Irradiation.

Clin Breast Cancer 2020 Apr 17. Epub 2020 Apr 17.

Department of Radiation Oncology, Lifespan Cancer Institute, Alpert Medical School of Brown University, Providence, RI.

For early-stage breast cancer, partial breast irradiation (PBI) allows for reduction in the irradiated volume of normal tissues by confining the radiation target to the area surrounding the lumpectomy cavity after breast-conserving surgery. This approach has been supported by phase 2 data. However, widespread adoption of PBI has awaited the results of randomized controlled trials. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.04.003DOI Listing

Multispectral quantitative immunohistochemical analysis of tumor-infiltrating lymphocytes in relation to programmed death-ligand 1 expression in triple-negative breast cancer.

Breast Cancer 2020 May 23. Epub 2020 May 23.

Department of Pathology, Kawasaki Medical School, Kurashiki, Japan.

Background: Programmed death-ligand 1 (PD-L1) expression on immune cells (ICs) is a predictive marker for PD-L1 checkpoint blockade in patients with triple-negative breast cancer (TNBC). However, the level of PD-L1 expression and the percentage of cells that are PD-L1+ are continuous variables not dichotomous variables for tumor-infiltrating lymphocytes (TILs) and other cells.

Methods: Multiplexed immunohistochemistry was applied to 31 archived surgical specimens from untreated TNBC patients. Read More

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http://dx.doi.org/10.1007/s12282-020-01110-2DOI Listing

Impact of Neoadjuvant Versus Adjuvant Chemotherapy on the Extent of Axillary Surgery for Clinically Node-Negative Breast Cancers of Triple-Negative and HER2-Overexpressing Phenotypes.

Clin Breast Cancer 2020 Apr 21. Epub 2020 Apr 21.

Spectrum Health General Surgery Residency Program, Grand Rapids, MI; Division of Surgical Oncology, Spectrum Health Medical Group, Grand Rapids, MI.

Background: Breast cancer patients with triple-negative or human epidermal growth factor receptor 2 (HER2)-overexpressing phenotypes are recommended to receive chemotherapy for primary tumors greater than 1 cm regardless of nodal status. Neoadjuvant chemotherapy may eradicate subclinical nodal metastases and reduce the extent of axillary surgery performed.

Patients And Methods: A query of the National Cancer Database Participant User File was performed for new cases of female breast cancer from 2012 to 2015. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.04.007DOI Listing

Performance analysis of the anti-Ki67 antibody clone 30-9 for immunohistochemical staining of breast cancer.

Breast Cancer 2020 May 21. Epub 2020 May 21.

Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Although Ki67 has important clinical relevance in breast cancer, its assessment results vary according to assay due to differences in both analytical and interpretation processes. We aimed to validate the performance of anti-Ki67 antibody clone 30-9 by comparison with clone MIB-1 and to investigate utility of the image analysis system in Ki67 assessment using clinical breast cancer samples.

Methods: A series of sequential tissue sections was prepared from formalin-fixed paraffin-embedded blocks of surgically resected breast cancer specimens from 50 patients. Read More

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http://dx.doi.org/10.1007/s12282-020-01108-wDOI Listing

Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials.

NPJ Breast Cancer 2020 12;6:15. Epub 2020 May 12.

3Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. Read More

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http://dx.doi.org/10.1038/s41523-020-0155-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217941PMC

Preoperative Predictive Factors of Positive Margin Status After Breast Conserving Therapy (BCT) with Intraoperative Radiation Therapy (IORT): A Retrospective Study of 400 Patients.

Clin Breast Cancer 2020 Apr 7. Epub 2020 Apr 7.

Department of Surgery, Center of Breast Care, Memorial Health University Medical Center, Savannah, GA.

Introduction: Single-fraction intraoperative radiation therapy (IORT) has emerged as a therapeutic option in patients undergoing breast conserving therapy (BCT) for early stage breast cancer, often eliminating the need for postoperative external beam radiation therapy. However, if a positive margin is encountered after BCT, the patient will ultimately require external beam radiation therapy. The purpose of this study was to identify preoperative factors from patient demographics, preoperative workup, or biopsy results that may be predictive of postoperative margin status. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.010DOI Listing

Elucidating Determinants of Survival Disparities Among a Real-world Cohort of Metastatic Breast Cancer Patients: A National Cancer Database Analysis.

Clin Breast Cancer 2020 Apr 18. Epub 2020 Apr 18.

Department of Hematology/Oncology, Maroone Cancer Center, Cleveland Clinic Florida, Weston, FL. Electronic address:

Background: Disparities in breast cancer survival by race/ethnicity and socioeconomic status have been reported. However, it is unclear if these findings are reproducible among subpopulations. This study aimed to assess if socially oriented factors are predictive of overall survival (OS) among patients with hormone receptor-positive (HR), human epidermal growth factor 2-positive (HER2) metastatic breast cancer (MBC). Read More

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http://dx.doi.org/10.1016/j.clbc.2020.04.002DOI Listing

Correction to: Histological classification of breast tumors in the General Rules for Clinical and Pathological Recording of Breast Cancer (18th edition).

Breast Cancer 2020 May 19. Epub 2020 May 19.

Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi Kami-cho, Itabashi-ku, Tokyo, 173-8610, Japan.

In the original publication of the article, the author group and acknowledgements were published incorrectly. Read More

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http://dx.doi.org/10.1007/s12282-020-01106-yDOI Listing

Clinicopathological, Treatment and Event-Free Survival Characteristics in a Moroccan Population of Triple-Negative Breast Cancer.

Breast Cancer (Auckl) 2020 29;14:1178223420906428. Epub 2020 Apr 29.

Equipe de recherche ONCOGYMA, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat, Morocco.

Introduction: Triple-negative breast cancer (TNBC) is a group of breast carcinoma characterized by the lack of expression of estrogen and progesterone hormone receptors (ER, PgR) and HER2. This form is also characterized by its aggressiveness, a low survival rate, and the absence of targeted therapies. This study was planned to evaluate the clinical features, treatment, and prognosis characteristics of TNBC in a population of Moroccan patients. Read More

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http://dx.doi.org/10.1177/1178223420906428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218339PMC

Wnt/β-Catenin Signaling Pathway as Chemotherapeutic Target in Breast Cancer: An Update on Pros and Cons.

Clin Breast Cancer 2020 Apr 18. Epub 2020 Apr 18.

Department of Oncogene Regulation, Chittaranjan National Cancer Institute, Kolkata, India.

The Wnt/β-catenin pathway, in addition to playing a crucial role in the development of the mammary gland during embryogenesis and during pregnancy, is one of the most commonly altered pathways in breast cancer. Accumulating findings from in vitro and in vivo and clinical studies have been suggestive of this pathway as a potential chemotherapy target. However, approved chemotherapeutic agents targeting this pathway are still missing for the treatment of patients with cancer. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.04.004DOI Listing

Utility of urinary type I collagen cross-linked N-telopeptide as a prognostic indicator in breast cancer patients with bone metastases.

Breast Cancer 2020 May 15. Epub 2020 May 15.

Department of Breast Surgery, Yokkaichi Municipal Hospital, 2-2-37 Shibata, Yokkaichi, Mie, 510-8567, Japan.

Background: Breast cancer patients with bone metastases are usually managed with bone modifying agents, such as zoledronic acid and denosumab, and some bone turnover markers (BTMs) have been recognized as prognostic indicators in such patients. Although several studies have demonstrated the validity of BTMs as prognostic markers in patients treated with zoledronic acid, few studies have reported the utility of BTMs with denosumab treatment. In this study, we evaluated whether urinary N-telopeptide of type I collagen (u-NTX) can be a prognostic indicator in patients treated with denosumab. Read More

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http://dx.doi.org/10.1007/s12282-020-01109-9DOI Listing

Research Progress on Long Non-coding RNAs and Drug Resistance of Breast Cancer.

Clin Breast Cancer 2020 Apr 30. Epub 2020 Apr 30.

Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China. Electronic address:

Breast cancer, as the foremost cause of women's death in the world, is highly metastatic and mutable. Resistance to drugs for chemotherapies, endocrine therapies, and targeted therapies is an important factor that impacts the prognosis of breast cancer. Long non-coding ribonucleic acids (LncRNAs) are crucial regulators of intracellular gene expressions. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.11.001DOI Listing

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer.

NPJ Breast Cancer 2020 12;6:17. Epub 2020 May 12.

21Division of Research and Cancer Medicine, Peter MacCallum Cancer Centre, University of Melbourne, Melbourne, VIC Australia.

Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. Read More

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http://dx.doi.org/10.1038/s41523-020-0156-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217863PMC

Report on computational assessment of Tumor Infiltrating Lymphocytes from the International Immuno-Oncology Biomarker Working Group.

NPJ Breast Cancer 2020 12;6:16. Epub 2020 May 12.

74Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL USA.

Assessment of tumor-infiltrating lymphocytes (TILs) is increasingly recognized as an integral part of the prognostic workflow in triple-negative (TNBC) and HER2-positive breast cancer, as well as many other solid tumors. This recognition has come about thanks to standardized visual reporting guidelines, which helped to reduce inter-reader variability. Now, there are ripe opportunities to employ computational methods that extract spatio-morphologic predictive features, enabling computer-aided diagnostics. Read More

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http://dx.doi.org/10.1038/s41523-020-0154-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217824PMC

Extending Screening in "Elderly" Patients: Should We Consider a Selective Approach?

Clin Breast Cancer 2020 Apr 6. Epub 2020 Apr 6.

Department of Surgery, Auckland City Hospital, Auckland, New Zealand.

Background: Breast cancer screening has been shown to reduce breast cancer-associated mortality. However, screening is limited to the targeted age group of 45 to 69 years in New Zealand despite the recognized increased risk with age. This study aims to compare the outcomes of women aged over 70 years with screen-detected and clinically detected cancers. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.009DOI Listing

Annual report of the Japanese Breast Cancer Society registry for 2016.

Breast Cancer 2020 May 11. Epub 2020 May 11.

Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8606, Japan.

The Japanese Breast Cancer Society (JBCS) registry began data collection in 1975, and it was integrated into National Clinical Database in 2012. As of 2016, the JBCS registry contains records of 656,896 breast cancer patients from more than 1400 hospitals throughout Japan. In the 2016 registration, the number of institutes involved was 1422, and the total number of patients was 95,870. Read More

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http://dx.doi.org/10.1007/s12282-020-01081-4DOI Listing

The efficacy of sequential second-line endocrine therapies (ETs) in postmenopausal estrogen receptor-positive and HER2-negative metastatic breast cancer patients with lower sensitivity to initial ETs.

Breast Cancer 2020 May 11. Epub 2020 May 11.

Department of Breast and Endocrine Surgery, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Purpose: Second-line endocrine therapy (ET) for estrogen receptor (ER)-positive and human epidermal growth factor 2 (HER2)-negative metastatic breast cancer (MBC) is offered based on the response to first-line ET. However, no clinical trials have evaluated the efficacy and safety of secondary ETs in patients with poor responses to initial ET. This study evaluated the efficacy of second-line ET in ER-positive and HER2-negative postmenopausal MBC patients with low or very low sensitivity to initial ET. Read More

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http://dx.doi.org/10.1007/s12282-020-01095-yDOI Listing

Patient-reported Upper Limb Function After Sentinel Lymph Node Biopsy for Breast Cancer: A Prospective Observational Study.

Clin Breast Cancer 2020 Apr 10. Epub 2020 Apr 10.

Department of Breast Surgery, University Hospitals of North Midlands, Stoke-on-Trent, United Kingdom. Electronic address:

Introduction: Sentinel lymph node biopsy (SLNB) is the standard procedure for axillary staging in breast cancer. There is a lack of consistency in studies reporting on upper limb morbidity after SLNB. We present a prospective study evaluating upper limb function after SLNB using the validated quickDASH questionnaire. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.014DOI Listing

Can Low-cost Indo Cyanine Green Florescence Technique for Sentinel Lymph Node Biopsy Replace Dual Dye (Radio-colloid and Blue Dye) Technique in Early Breast Cancer: A Prospective Two-arm Comparative Study.

Clin Breast Cancer 2020 Apr 6. Epub 2020 Apr 6.

Department of Pathology, Manipal Comprehensive Cancer Centre, Manipal Hospital, Bangalore, India.

Background: The objective of this study was to assess the detection and accuracy of sentinel lymph node (SLN) biopsy (SLNB) using the low-cost indocyanine green (ICG) fluorescence method and to compare this method with the gold standard dual-dye method (radio-colloid + methylene blue dye [MB]).

Materials And Methods: One hundred patients with node-negative early breast cancer assessed clinically and by ultrasound axilla underwent an SLNB procedure using technetium-99m radio-colloid, MB, and ICG. The detection rate of SLNs and positive SLNs and the number of SLNs were compared. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.013DOI Listing

Prediction of Oncotype DX recurrence score using deep multi-layer perceptrons in estrogen receptor-positive, HER2-negative breast cancer.

Breast Cancer 2020 May 8. Epub 2020 May 8.

Department of Pathology, Nord Franche Comte Hospital, 100 route de Moval, CS 10499 Trevenans, 90015, Belfort, France.

Oncotype DX (ODX) is a multi-gene expression signature designed for estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients to predict the recurrence score (RS) and chemotherapy (CT) benefit. The aim of our study is to develop a prediction tool for the three RS's categories based on deep multi-layer perceptrons (DMLP) and using only the morphoimmunohistological variables. We performed a retrospective cohort of 320 patients who underwent ODX testing from three French hospitals. Read More

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http://dx.doi.org/10.1007/s12282-020-01100-4DOI Listing

Novel module and hub genes of distinctive breast cancer associated fibroblasts identified by weighted gene co-expression network analysis.

Breast Cancer 2020 May 1. Epub 2020 May 1.

Department of Breast and Thyroid Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Background: As abundant and heterogeneous stromal cells in tumor microenvironment, carcinoma-associated fibroblasts (CAFs) are critically involved in cancer progression.

Methods: To identify co-expression module and hub genes of distinctive breast CAFs, weighted gene co-expression network analysis (WGCNA) was conducted based on the expression array results of CAFs from seven chemo-sensitive breast cancer (BC) patients and seven chemo-resistant ones before neo-adjuvant chemotherapy.

Results: A total of 4916 genes were included in WGCNA, and 12 modules were determined. Read More

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http://dx.doi.org/10.1007/s12282-020-01101-3DOI Listing

RANKLed by the Complexity of Signaling in Breast Cancer Metastasis to the Brain.

Clin Breast Cancer 2020 Apr 11. Epub 2020 Apr 11.

Department of Pathology, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Background: Receptor activator of nuclear factor κB (RANK) and its ligand, RANKL, are essential for mammary gland development and play a vital role in breast carcinogenesis. RANKL-RANK signaling also drives thermoregulation and modulates inflammatory activation in the brain. The expression of RANKL in primary breast cancer (BC) has been negatively associated with brain metastases, while significantly higher levels of RANK are seen in BC with brain metastases. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.04.001DOI Listing

The association between MRI findings and breast cancer subtypes: focused on the combination patterns on diffusion-weighted and T2-weighted images.

Breast Cancer 2020 May 6. Epub 2020 May 6.

Breast Research Center, The Shinko Institution for Medical Research, Shinko Hospital, 1-4-47, Wakinohama Chuo, Kobe, 651-0072, Japan.

Purpose: To assess morphology on diffusion-weighted imaging (DWI) and intratumoral signal intensity (SI) on T2-weighted images (T2WI) of breast carcinomas, and to evaluate the association between the combined DWI and T2WI findings and breast cancer subtypes.

Methods: Two hundred and eighty breast cancer patients who underwent breast MRI prior to therapy were included in this retrospective study. All had invasive carcinomas, which were classified into five subtypes: Luminal A-like (n = 149), Luminal B-like (n = 63), Hormone receptor-positive HER2 (n = 31), Hormone receptor-negative HER2 (n = 13), or Triple-negative (TN) (n = 24). Read More

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http://dx.doi.org/10.1007/s12282-020-01105-zDOI Listing

Evaluation of ductal carcinoma in situ grade via triple-modal molecular imaging of B7-H3 expression.

NPJ Breast Cancer 2020 29;6:14. Epub 2020 Apr 29.

1Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, School of Medicine, Stanford, CA USA.

Ductal carcinoma in situ (DCIS) will account for 62,930 cases of breast cancer in 2019. DCIS is a pre-invasive lesion which may not progress to invasive carcinoma, yet surgery remains the mainstay treatment. Molecular imaging of a specific marker for DCIS grade for detection and active surveillance are critically needed to reduce potential overtreatment. Read More

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http://dx.doi.org/10.1038/s41523-020-0158-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190737PMC

Prediction of the functional impact of missense variants in BRCA1 and BRCA2 with BRCA-ML.

NPJ Breast Cancer 2020 29;6:13. Epub 2020 Apr 29.

1Department of Health Sciences Research, Mayo Clinic, Rochester, MN USA.

In silico predictions of missense variants is an important consideration when interpreting variants of uncertain significance (VUS) in the and genes. We trained and evaluated hundreds of machine learning algorithms based on results from validated functional assays to better predict missense variants in these genes as damaging or neutral. This new optimal "BRCA-ML" model yielded a substantially more accurate method than current algorithms for interpreting the functional impact of variants in these genes, making BRCA-ML a valuable addition to data sources for VUS classification. Read More

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http://dx.doi.org/10.1038/s41523-020-0159-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190647PMC

Nipple-sparing mastectomy for breast cancer close to the nipple: a single institution's 11-year experience.

Breast Cancer 2020 May 5. Epub 2020 May 5.

Department of Surgery and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.

Background: This study aimed to analyze our 11-year experience using NSM with immediate breast reconstruction in breast cancer.

Methods: Between January 2007 and December 2015, 251 NSMs were performed on 251 women with breast cancer for therapeutic purpose at Pusan National University Hospital.

Results: The clinical and pathologic mean tumor size was 3. Read More

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http://dx.doi.org/10.1007/s12282-020-01104-0DOI Listing

Integrative review of breast cancer survivors' transition experience and transitional care: dialog with transition theory perspectives.

Breast Cancer 2020 May 5. Epub 2020 May 5.

Institute of Community Health Care, School of Nursing, National Yang-Ming University, No. 155, Sec. 2, Linong St. Beitou District, Taipei City, 11221, Taiwan, ROC.

The health of breast cancer survivors (BCSs) is an essential concern worldwide. This review summarizes current knowledge and proposes a novel framework for understanding BCSs' transition experiences and adopting a more holistic view of transitional care to ensure a successful shift from patient-to-survivor. An integrative review was applied whereby we searched CINAHL, MEDLINE, PubMed, and ProQuest. Read More

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http://dx.doi.org/10.1007/s12282-020-01097-wDOI Listing

The Role of Contrast-Enhanced Ultrasound in the Diagnosis and Pathologic Response Prediction in Breast Cancer: A Meta-analysis and Systematic Review.

Clin Breast Cancer 2020 Mar 20. Epub 2020 Mar 20.

Department of Ultrasonography, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Purpose: To determine the overall performance of contrast-enhanced ultrasound (CEUS) in differentiating between benign and malignant breast lesions and in predicting the pathologic response to neoadjuvant chemotherapy (NAC) in patients with breast cancer (BC).

Materials And Methods: Articles published up to April 2019 were systematically searched in Medline, Web of Science, and China National Knowledge Infrastructure. The sensitivities and specificities across studies, the calculations of positive and negative likelihood ratios (LR and LR), diagnostic odds ratio (OR), and constructed summary receiver operating characteristic curves were determined. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.002DOI Listing

Non-invasive quantitative measures of qualitative grading effectiveness as the indices of acute radiation dermatitis in breast cancer patients.

Breast Cancer 2020 May 3. Epub 2020 May 3.

Appearance Support Center, National Cancer Center Hospital, Tokyo, Japan.

Background: Recent improvement of machinery evaluation for the skin changes in various therapies enabled us to evaluate fine changes quantitatively. In this study, we performed evaluation of the changes in radiation dermatitis (RD) using quantitative and qualitative methods, and verified the validity of the conventional qualitative assessment for clinical use.

Methods: Forty-three breast cancer patients received conventional fractionated radiotherapy to whole breast after breast-conserving surgery. Read More

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http://dx.doi.org/10.1007/s12282-020-01082-3DOI Listing

Dietary Patterns and Risk of Invasive Ductal and Lobular Breast Carcinomas: A Systematic Review and Meta-analysis.

Clin Breast Cancer 2020 Mar 28. Epub 2020 Mar 28.

Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway; Department of Research, Cancer Registry of Norway, Oslo, Norway.

The histopathologic subtypes of breast cancer, including invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC), differ in terms of risk factors, progression, and response to treatment. The PubMed/Medline, Web of Science, and Scopus databases were searched up to February 2020 for published studies on the association between dietary patterns (Western diet [WD] or Mediterranean diet [WD]) and the risk of IDC/ILC of breast. Multivariable adjusted relative risk (RR) and 95% confidence intervals (CIs) comparing the highest and lowest categories of WD and MD patterns were combined by using the random-effects meta-analyses. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.007DOI Listing
March 2020
2.107 Impact Factor

A case of bilateral methotrexate-associated diffuse large B-cell lymphomas of the breasts with unique clinical presentation and outcome.

Breast Cancer 2020 May 2. Epub 2020 May 2.

Department of Surgery, Kishiwada Tokushukai Hospital, 4-27-1, Kamori-cho, Kishiwada, Osaka, 596-8522, Japan.

A 54-year-old woman on methotrexate (MTX) treatment developed reddish skin change in her right breast. Mammography and ultrasound showed no masses in the breasts but bilateral mammary glands presented diffuse lower-level echoes. Only 19 days later, the patient developed bilateral breast masses. Read More

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http://dx.doi.org/10.1007/s12282-020-01102-2DOI Listing

BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression.

NPJ Breast Cancer 2020 24;6:12. Epub 2020 Apr 24.

13Department of Pathology and Laboratory Medicine, MS 3045, The University of Kansas Medical Center, Kansas City, KS 66160 USA.

The molecular processes by which some human ductal carcinoma in situ (DCIS) lesions advance to the more aggressive form, while others remain indolent, are largely unknown. Experiments utilizing a patient-derived (PDX) DCIS Mouse INtraDuctal (MIND) animal model combined with ChIP-exo and RNA sequencing revealed that the formation of protein complexes between B Cell Lymphoma-9 (BCL9), phosphoserine 727 STAT3 (PS-727-STAT3) and non-STAT3 transcription factors on chromatin enhancers lead to subsequent transcription of key drivers of DCIS malignancy. Downregulation of two such targets, integrin β3 and its associated metalloproteinase, MMP16, resulted in a significant inhibition of DCIS invasive progression. Read More

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http://dx.doi.org/10.1038/s41523-020-0157-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181646PMC

The era of meta-analyses-based recommendations: how were the Japanese Breast Cancer Society Clinical Practice Guidelines for Systemic Treatment of Breast Cancer established?

Authors:
Toshimi Takano

Breast Cancer 2020 May;27(3):332-333

Breast Medical Oncology Department, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

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http://dx.doi.org/10.1007/s12282-020-01099-8DOI Listing

Association of Tagging Single Nucleotide Polymorphisms With Breast Cancer in a Sample of Colombian Population: A Case Control Study.

Breast Cancer (Auckl) 2020 20;14:1178223420904939. Epub 2020 Apr 20.

Faculty of Medicine, Universidad de la Sabana, Chía, Colombia.

Purpose: Ubiquitin ligase genes can act as oncogenes or tumor suppressor genes. They play a role in various diseases, including development and progression of breast cancer; the objective of this study was to evaluate the association of common variants in the () gene with breast cancer risk in a sample of Colombian population.

Methods: We carried out a case-control study to investigate associations of variants in with breast cancer in women from Colombia. Read More

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http://dx.doi.org/10.1177/1178223420904939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172001PMC

Upregulated cyclins may be novel genes for triple-negative breast cancer based on bioinformatic analysis.

Breast Cancer 2020 Apr 27. Epub 2020 Apr 27.

College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, China.

Background: Triple-negative breast cancer (TNBC) is one of the leading causes of death among females around the world. However, the molecular mechanism of the disease among TNBC patients remains to be further studied.

Methods: In our study, four microarray data and two high throughput sequencing data were acquired from the GEO database, and the differentially expressed genes (DEGs) between TNBC and normal tissues had been analyzed. Read More

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http://dx.doi.org/10.1007/s12282-020-01086-zDOI Listing
April 2020
1.505 Impact Factor

A Review of Breast Density Implications and Breast Cancer Screening.

Clin Breast Cancer 2020 Mar 20. Epub 2020 Mar 20.

Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, P.R. China. Electronic address:

Breast density is an independent risk factor for breast cancer and significantly decreases the sensitivity of mammography. Assessing a woman's risk of developing breast cancer is becoming increasingly important for establishing individual screening recommendations and preventive strategies. This article reviews the factors influencing mammographic density (MD), the available methods of MD assessment, and its effect on breast cancer. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.004DOI Listing

Enhancing chemosensitivity of wild-type and drug-resistant MDA-MB-231 triple-negative breast cancer cell line to doxorubicin by silencing of STAT 3, Notch-1, and β-catenin genes.

Breast Cancer 2020 Apr 23. Epub 2020 Apr 23.

Cell Therapy Center, The University of Jordan, PO Box: 5825, Amman, 11942, Jordan.

Background/objective: The absence of receptors in triple-negative breast cancer limits therapeutic choices utilized in clinical management of the disease. Doxorubicin is an important member of therapeutic regimens that is hindered by emergence of resistance. The current work aim to investigate of therapeutic potential of single and combinations of siRNA molecules designed for silencing STAT 3, Notch-1, and β-catenin genes in wild type and doxorubicin resistant MDA-MB-231 triple negative breast cancer cell line. Read More

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http://dx.doi.org/10.1007/s12282-020-01098-9DOI Listing

Evaluating Family History Links between Breast Cancer and Prostate Cancer Among PLCO Trial Participants.

Clin Breast Cancer 2020 Mar 20. Epub 2020 Mar 20.

Department of Oncology, University of Alberta and Cross Cancer Institute, Edmonton, Alberta, Canada; Clinical Oncology Department, Ain Shams University, Cairo, Egypt. Electronic address:

Introduction: The objective of this study was to assess family history links between breast cancer and prostate cancer in a prospectively collected cohort from the Prostate, Lung, Colorectal, and Ovary (PLCO) trial.

Patients And Methods: This is a secondary analysis of the PLCO trial datasets. Eligible patients included female participants with complete information about prostate cancer family history and male participants with complete information about breast cancer family history. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.005DOI Listing
March 2020
2.107 Impact Factor

Use of Adjuvant Breast Hypofractionation Radiation Treatment at a Cancer Center in Ontario From 2011 to 2018.

Clin Breast Cancer 2020 Mar 28. Epub 2020 Mar 28.

Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: The adoption of hypofractionated radiotherapy (HFRT) into clinical practice varies widely despite randomized trials and guidelines supporting its equivalence to conventional fractionated radiotherapy (CFRT) for certain patient populations. We assessed the use of HFRT at a single institution from 2011 to 2018, as well as time-savings calculations.

Patients And Methods: A retrospective cohort study was conducted for patients with breast cancer receiving adjuvant radiotherapy by HFRT or CFRT. Read More

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http://dx.doi.org/10.1016/j.clbc.2020.03.006DOI Listing

Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance.

Breast Cancer 2020 Apr 20. Epub 2020 Apr 20.

Department of Pathology and Histotechnology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi-ken, 980-8575, Japan.

Background: RAS-related C3 botulinus toxin substrate 1 (Rac1) is a molecular switch fluctuating between GDP-bound inactive form (Rac1-GDP) and GTP-bound active form (Rac1-GTP) and involved in diverse function in both normal and malignant cells such as breast carcinoma cells. Although several studies have demonstrated immunolocalization of Rac1 protein in human breast carcinoma tissues, activation status of Rac1 still remains to be elucidated.

Methods: We immunolocalized active form of Rac1 (Rac1-GTP) as well as total Rac1 using antibody specific for them in 115 invasive breast carcinoma tissues and correlated with clinicopathological parameters and clinical outcomes. Read More

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http://dx.doi.org/10.1007/s12282-020-01091-2DOI Listing