478,180 results match your criteria Breast Cancer: Basic and Clinical Research [Journal]


Permselective glucose sensing with GLUT1-rich cancer cell membranes.

Biosens Bioelectron 2019 Apr 12;135:82-87. Epub 2019 Apr 12.

School of Biomedical Engineering, Korea University, Seoul, 02841, Republic of Korea. Electronic address:

Enzymatic blood glucose detection with selectivity is one of the most important conundrums, because human blood contains many components that can hinder enzyme-substrate reactions. Meanwhile, cancer cells express much higher levels of glucose transporter-1 on their cell membrane to selectively and excessively uptake more α-D-glucose than do normal cells. Inspired by such cellular permselectivity for glucose, herein we significantly improved the selectivity of a glucose sensor by using a breast cancer cell membrane (BCCM). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09565663193028
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http://dx.doi.org/10.1016/j.bios.2019.04.007DOI Listing
April 2019
1 Read
6.409 Impact Factor

Direct quantification of cancerous exosomes via surface plasmon resonance with dual gold nanoparticle-assisted signal amplification.

Biosens Bioelectron 2019 Apr 13;135:129-136. Epub 2019 Apr 13.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha, 410082, China. Electronic address:

Sensitive detection of cancerous exosomes is critical to early diseases diagnosis and prognosis. Herein, a sensitive aptasensor was demonstrated for exosomes detection by surface plasmon resonance (SPR) with dual gold nanoparticle (AuNP)-assisted signal amplification. Dual nanoparticle amplification was achieved by controlled hybridization attachment of AuNPs resulting from electronic coupling between the Au film and AuNPs, as well as coupling effects in plasmonic nanostructures. Read More

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http://dx.doi.org/10.1016/j.bios.2019.04.013DOI Listing

Inhibition of 3β-Hydroxysteroid Dehydrogenase Type 1 Suppresses Interleukin-6 in Breast Cancer.

J Surg Res 2019 Apr 17;241:8-14. Epub 2019 Apr 17.

Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan. Electronic address:

Background: Recently, we demonstrated that the expression of 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth. However, the mechanisms are unclear.

Methods: Triple-negative MDA-MB-231 and BT-20 breast cancer cells underwent HSD3B1 silencing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.024DOI Listing
April 2019
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Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli.

Protein Expr Purif 2019 Apr 17. Epub 2019 Apr 17.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:

Survivin is a well-known inhibitor-of-apoptosis proteins family member and a promising molecular target for anti-cancer treatment. However, it is widely accepted that survivin is only a "semi-druggable" target and development of survivin-specific small molecule inhibitors has shown to be difficult. In this study, we demonstrated that a histidine-tagged survivin T34A-C84A mutated protein (T34A-C84A-dNSur-His) can be produced using a bacterial recombinant protein expression system [E. Read More

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http://dx.doi.org/10.1016/j.pep.2019.04.003DOI Listing

MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 17. Epub 2019 Apr 17.

Scuola Superiore Sant'Anna, Institute of Life Sciences, 56124 Pisa, Italy. Electronic address:

The capacity of inducing angiogenesis is a recognized hallmark of cancer cells. The cancer microenvironment, characterized by hypoxia and inflammatory signals, promotes proliferation, migration and activation of quiescent endothelial cells (EC) from surrounding vascular network. Current anti-angiogenic drugs present side effects, temporary efficacy, and issues of primary resistance, thereby calling for the identification of new therapeutic targets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193011
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http://dx.doi.org/10.1016/j.bbadis.2019.04.008DOI Listing
April 2019
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Anti-tumor properties of methoxylated analogues of resveratrol in malignant MCF-7 but not in non-tumorigenic MCF-10A mammary epithelial cell lines.

Toxicology 2019 Apr 17. Epub 2019 Apr 17.

Institute for Risk Assessment Sciences, Toxicology Department, Utrecht University, Yalelaan 104, 3584 CM, Utrecht, the Netherlands.

Resveratrol is a plant-derived polyphenol that is known for its anti-inflammatory and anti-tumorigenic properties in in vitro and in vivo models. Recent studies show that some resveratrol analogues might be more potent anti-tumor agents, which may partly be attributed to their ability to activate the aryl hydrocarbon receptor (AHR). Here, the anti-tumorigenic properties of resveratrol and structural analogues oxyresveratrol, pinostilbene, pterostilbene and tetramethoxystilbene (TMS) were studied in vitro, using in the malignant human MCF-7 breast cancer cell line and non-tumorigenic breast epithelial cell line MCF-10 A. Read More

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http://dx.doi.org/10.1016/j.tox.2019.04.009DOI Listing

miR-374a-5p Promotes Tumor Progression by Targeting ARRB1 in Triple Negative Breast Cancer.

Cancer Lett 2019 Apr 17. Epub 2019 Apr 17.

Department of Biological Science, Sookmyung Women's University, Seoul, Republic of Korea. Electronic address:

Triple negative breast cancer (TNBC) has higher aggressiveness and poorer outcomes compared with other subtypes of breast cancer. However, the genomic and molecular aberrations of TNBC are largely unknown. In this study, miR-374a-5p was discovered as a novel TNBC-specific miRNA and its functions and the molecular mechanisms involved were investigated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03043835193023
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http://dx.doi.org/10.1016/j.canlet.2019.04.006DOI Listing
April 2019
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Hyaluronic acid - dihydroartemisinin conjugate: Synthesis, characterization and in vitro evaluation in lung cancer cells.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Product Development Cell-II, National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address:

In recent years, a great deal of attention has been given towards re-purposing and re-innovating the potential drugs. In this regard, dihydroartemisinin (DHA) has been reported to demonstrate anti-proliferative effects on various cancerous cells viz. breast, liver and lung. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.124DOI Listing

Involvement of ABC transporters in the efflux and toxicity of MPA-COOH-CdTe quantum dots in human breast cancer SK-BR-3 cells.

J Biochem Mol Toxicol 2019 Apr 20:e22343. Epub 2019 Apr 20.

Department of cardiothoracic surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, PR China.

This paper aimed to study the possible involvement of adenosine triphosphate-binding cassette (ABC) transporters in the detoxification of quantum dots (QDs) in human breast carcinoma (SK-BR-3) cells. The effects of QD sizes on such interactions were also evaluated. For this purpose, we used monodispersed MPA-COOH-CdTe QDs with different diameters (emission length at 560 and 625 nm, named as QD-560 and QD-625). Read More

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http://dx.doi.org/10.1002/jbt.22343DOI Listing

Fulvestrant in the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer: A review.

Cancer Med 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery in Breast Cancer, Fudan University Shanghai Cancer Center, Shanghai, China.

Nearly 75% of breast cancers are hormone receptor-positive (HR+) and human epidermal growth factor receptor type 2-negative (HER2-), making endocrine therapy the mainstay of treatment for HR+ and HER2- combination. Although endocrine therapy, such as therapy with fulvestrant, is widely used in the clinic, endocrine resistance (primary or secondary) is inevitable and poses a serious clinical concern. However, the therapeutic landscape of HR+/HER2- breast cancer is rapidly changing and evolving. Read More

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http://dx.doi.org/10.1002/cam4.2095DOI Listing

Background parenchymal enhancement on breast MRI: A comprehensive review.

J Magn Reson Imaging 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA.

The degree of normal fibroglandular tissue that enhances on breast MRI, known as background parenchymal enhancement (BPE), was initially described as an incidental finding that could affect interpretation performance. While BPE is now established to be a physiologic phenomenon that is affected by both endogenous and exogenous hormone levels, evidence supporting the notion that BPE frequently masks breast cancers is limited. However, compelling data have emerged to suggest BPE is an independent marker of breast cancer risk and breast cancer treatment outcomes. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/jmri.26762
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http://dx.doi.org/10.1002/jmri.26762DOI Listing
April 2019
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The cost of diabetic foot ulcers and amputations to the National Health Service in England.

Diabet Med 2019 Apr 19. Epub 2019 Apr 19.

Nottingham University Hospitals NHS Trust, Nottingham, UK.

Aim: To estimate the healthcare costs of diabetic foot disease in England.

Methods: Patient-level data sets at a national and local level, and evidence from clinical studies, were used to estimate the annual cost of health care for foot ulceration and amputation in people with diabetes in England in 2014-2015.

Results: The cost of health care for ulceration and amputation in diabetes in 2014-2015 is estimated at between £837 million and £962 million; 0. Read More

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http://dx.doi.org/10.1111/dme.13973DOI Listing

In silico markers: an evolutionary and statistical approach to select informative genes of human breast cancer subtypes.

Genes Genomics 2019 Apr 19. Epub 2019 Apr 19.

Department of Informatics, University of Evora, 7004-516, Evora, Portugal.

Background: Recent advancement in bioinformatics offers the ability to identify informative genes from high dimensional gene expression data. Selection of informative genes from these large datasets has emerged as an issue of major concern among researchers.

Objective: Gene functionality and regulatory mechanisms can be understood through the analysis of these gene expression data. Read More

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http://dx.doi.org/10.1007/s13258-019-00816-8DOI Listing

Cytotoxicity screening of supercritical fluid extracted seaweeds and phenylpropanoids.

Mol Biol Rep 2019 Apr 19. Epub 2019 Apr 19.

Department of Bioengineering, Faculty of Engineering, Ege University, 35100, Bornova, Izmir, Turkey.

Detached leaves of Posidonia oceanica and Zostera marina creating nuisance at the shores were extracted by means of supercritical CO enriched with a co-solvent, compared with that of soxhlet extraction. The extracts and their active compounds which are phenylpropanoids (chicoric, p-coumaric, rosmarinic, benzoic, ferulic and caffeic acids) were screened for cytotoxicity in cancer cell lines including human breast adenocarcinoma (MCF-7, MDA-MB-231, SK-BR-3), human colon adenocarcinoma (HT-29), human cervix adenocarcinoma (HeLa), human prostate adenocarcinoma (PC-3), Mus musculus neuroblastoma (Neuro 2A) cell lines and African green monkey kidney (VERO) as healthy cell line. Supercritical CO extracts proved to be more active than soxhlet counterparts. Read More

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http://link.springer.com/10.1007/s11033-019-04812-9
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http://dx.doi.org/10.1007/s11033-019-04812-9DOI Listing
April 2019
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Local-regional recurrence in women with small node-negative, HER2-positive breast cancer: results from a prospective multi-institutional study (the APT trial).

Breast Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

Purpose: Women with HER2-positive breast cancer treated prior to effective anti-HER2 therapy have higher rates of local-regional recurrence (LRR) than those with HER2-negative disease. Effective systemic therapy, however, has been shown to decrease LRR. This study examines LRR in women with HER2-positive breast cancer treated on a single-arm prospective multicenter trial of adjuvant trastuzumab (H) and paclitaxel (T). Read More

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http://dx.doi.org/10.1007/s10549-019-05238-4DOI Listing

The relation between stressful life events and breast cancer: a systematic review and meta-analysis of cohort studies.

Breast Cancer Res Treat 2019 Apr 19. Epub 2019 Apr 19.

Department of Social Medicine, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran.

Purpose: Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer.

Methods: We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. Read More

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http://dx.doi.org/10.1007/s10549-019-05231-xDOI Listing
April 2019
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The YB-1/EZH2/amphiregulin signaling axis mediates LPA-induced breast cancer cell invasion.

Arch Pharm Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmacology, College of Medicine, Konyang University, Myunggok Medical Building, 158 Gwanjeodong-ro, Seo-gu, Daejeon, 35365, Republic of Korea.

Lysophosphatidic acid (LPA) has been known to induce epithelial-mesenchymal transition (EMT) to stimulate cancer cell invasion, and resveratrol (3,5,4'-trans-trihydroxystilbene; REV) suppresses the invasion and metastasis of various cancers. The current study aimed to identify the underlying mechanism by which LPA aggravates breast cancer cell invasion and the reversal of this phenomenon. Immunoblotting and quantitative RT-PCR analysis revealed that LPA induces amphiregulin (AREG) expression. Read More

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http://link.springer.com/10.1007/s12272-019-01149-6
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http://dx.doi.org/10.1007/s12272-019-01149-6DOI Listing
April 2019
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Expression of tetraspanins NET-6 and CD151 in breast cancer as a potential tumor biomarker.

Clin Exp Med 2019 Apr 20. Epub 2019 Apr 20.

Department of Laboratory Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.

Tetraspanins have been implicated in multiple biological functions including protein networking and cell signaling. NET-6 (TSPAN 13) has been demonstrated to be a tumor suppressor gene in breast cancer, while CD151 is more likely to act as an oncogene. However, the biological function of both proteins is still inconclusive. Read More

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http://dx.doi.org/10.1007/s10238-019-00554-xDOI Listing

Examination of novel 4-aminoquinoline derivatives designed and synthesized by a hybrid pharmacophore approach to enhance their anticancer activities.

Sci Rep 2019 Apr 19;9(1):6315. Epub 2019 Apr 19.

Health Sciences North Research Institute, 56 Walfor Road, Sudbury, Ontario, P3E 2H3, Canada.

In an attempt to develop effective and potentially safe anticancer agents, thirty-six 4-aminoquinoline derived sulfonyl analogs were designed and synthesized using a hybrid pharmacophore approach. The cytotoxicity of these compounds was determined using three breast tumor cell lines (MDA-MB231, MDA-MB468 and MCF7) and two matching non-cancer breast epithelial cell lines (184B5 and MCF10A). Although most of the compounds were quite effective on the breast cancer cells, the compound 7-chloro-4-(4-(2,4-dinitrophenylsulfonyl)piperazin-1-yl)quinoline (13; VR23) emerged as potentially the most desirable one in this series of compounds. Read More

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http://www.nature.com/articles/s41598-019-42816-4
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http://dx.doi.org/10.1038/s41598-019-42816-4DOI Listing
April 2019
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Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy.

Postgrad Med J 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Queen Mary Hospital, Hong Kong, China

Background: Over the last 10 years, there has been a major treatment revolution for early human epidermal growth factor receptor 2 (HER2)-positive breast cancer. We aimed to explore the outcome of different neoadjuvant chemotherapy in a tertiary breast cancer centre with early HER2-positive breast cancer as well as factors associated with pathological complete response (pCR) and recurrence-free survival (RFS). The pattern of recurrence was also studied. Read More

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http://pmj.bmj.com/lookup/doi/10.1136/postgradmedj-2018-1357
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http://dx.doi.org/10.1136/postgradmedj-2018-135739DOI Listing
April 2019
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A constitutional activating MET mutation makes the genetic link between malignancies and chronic inflammatory diseases.

Clin Cancer Res 2019 Apr 19. Epub 2019 Apr 19.

Inserm U1165, University Paris 7.

Purpose: The genesis of all cancers results from an accumulation of mutations, constitutional and/or acquired when induced by external mutagenic factors. High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic changes.

Experimental Design: Here, we proposed an innovative individual approach by studying tissue samples from a young woman with an unusual association of breast cancer, polycythemia vera and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3261DOI Listing

"A natural progression" - Australian women's attitudes about an individualised breast screening model.

Cancer Prev Res (Phila) 2019 Apr 19. Epub 2019 Apr 19.

Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre.

Individualised screening is our logical next step to improve population breast cancer screening in Australia. In order to explore breast screening participants' views of the current program in Victoria, Australia, examine their openness to change and attitudes toward an individualised screening model this qualitative work was performed. This work was designed to inform the development of a decision aid to facilitate women's decisions about participating in individualised screening, and to elicit Australian consumer perspectives on the international movement toward individualised breast screening. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0443DOI Listing
April 2019
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Women's experiences of breast cancer reveal the need for a holistic person-centred approach to breast cancer care.

Authors:
Úna Kerin

Evid Based Nurs 2019 Apr 19. Epub 2019 Apr 19.

Department of Adult Nursing, School of Nursing and Midwifery, Birmingham City University, Birmingham, UK.

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http://dx.doi.org/10.1136/ebnurs-2019-103087DOI Listing

Circulating adipokines and risk of obesity related cancers: A systematic review and meta-analysis.

Obes Res Clin Pract 2019 Apr 16. Epub 2019 Apr 16.

Department of Family Medicine, Center for Obesity, Metabolism and Nutrition, Dongguk University Ilsan Hospital, 27 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do 10326, South Korea. Electronic address:

Background: Obesity can influence on carcinogenesis through alterations in adipokines and subsequent inflammatory changes. This meta-analysis was aimed to comprehensively assess the association between circulating adipokines and risk of obesity-related cancers.

Methods: Pubmed and Embase were searched up to October 2017 for observational studies investigating the relationship between adipokines and cancers. Read More

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http://dx.doi.org/10.1016/j.orcp.2019.03.006DOI Listing
April 2019
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Predictive factors of unexpected lymphatic drainage pathways in early-stage cervical cancer.

Gynecol Oncol 2019 Apr 16. Epub 2019 Apr 16.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objectives: The purpose of this study was to describe sentinel lymph nodes (SLN) topography in patients with early-stage cervical cancer and to determine factors associated with atypical lymphatic drainage pathway (LDP).

Methods: We analyzed the data of two prospective multicentric trials on SLN biopsy for cervical cancer (SENTICOL I and II) in women undergoing surgery for early-stage cervical cancer. SLN detection was realized with a combined labeling technique (Patent blue and radioactive tracer). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193050
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http://dx.doi.org/10.1016/j.ygyno.2019.04.008DOI Listing
April 2019
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Use of complementary and alternative medicine among breast cancer patients in Hungary: A descriptive study.

Complement Ther Clin Pract 2019 May 27;35:195-200. Epub 2019 Feb 27.

Department of Nursing Science, Faculty of Health, University of Debrecen, Faculty of Health, University of Debrecen, 4400, Nyíregyháza, Sóstói u. 2-4., Hungary. Electronic address:

Background And Purpose: This study aimed to explore the prevalence of the use of complementary and alternative medicine (CAM) before diagnosis and during oncology therapy, and reveal the disclosure of CAM use among Hungarian breast cancer patients.

Materials And Methods: In a cross-sectional survey a self-administered questionnaire was used covering patients' demographics, oncology-related variables and various aspects of CAM use. Data were collected from 135 patients. Read More

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http://dx.doi.org/10.1016/j.ctcp.2019.02.013DOI Listing

The use of aloe vera in cancer radiation: An updated comprehensive review.

Complement Ther Clin Pract 2019 May 31;35:126-130. Epub 2019 Jan 31.

St. John Fisher College Wegmans School of Pharmacy, 3690 East Avenue, Rochester, NY, 14618, USA.

Introduction: Many cancer patients require radiation therapy and often experience adverse effects including erythema, itching, and pain. Aloe vera has been studied for its potential use in the prevention and treatment of radiation related adverse effects as it possesses a variety of properties and is considered an antioxidant and anti-inflammatory agent. Multiple controlled trials have been performed in order to evaluate the efficacy of aloe vera for the prevention and treatment of radiation side effects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17443881183051
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http://dx.doi.org/10.1016/j.ctcp.2019.01.013DOI Listing
May 2019
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PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery.

Molecules 2019 Apr 18;24(8). Epub 2019 Apr 18.

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China.

In recent years, polyureas with dynamic hindered urea bonds (HUBs), a class of promising biomedical polymers, have attracted wide attention as a result of their controlled hydrolytic properties. The effect of the chemical structures on the properties of polyureas and their assemblies has rarely been reported. In this study, four kinds of polyureas with different chemical groups have been synthesized, and the polyureas from cyclohexyl diisocyanate and tert-butyl diamine showed the fastest hydrolytic rate. Read More

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https://www.mdpi.com/1420-3049/24/8/1538
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http://dx.doi.org/10.3390/molecules24081538DOI Listing
April 2019
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New Insights into the Implication of Epigenetic Alterations in the EMT of Triple Negative Breast Cancer.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Laboratoire d'Oncologie Moléculaire, Centre Jean PERRIN et IMoST, UMR 1240, Inserm/Université Clermont Auvergne 58 rue Montalembert, 63000 Clermont-Ferrand, France.

Breast cancer is the most common cancer and leading cause of cancer death among women worldwide, encompassing a wide heterogeneity of subtypes with different clinical features. During the last two decades, the use of targeted therapies has emerged in clinical research in order to increase treatment efficiency, improve prognosis and reduce recurrence. However, the triple negative breast cancer (TNBC) subtype remains a clinical challenge, with poor prognosis since no therapeutic targets have been identified. Read More

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http://dx.doi.org/10.3390/cancers11040559DOI Listing

TRPC3 Regulates the Proliferation and Apoptosis Resistance of Triple Negative Breast Cancer Cells through the TRPC3/RASA4/MAPK Pathway.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

School of Life Sciences, The Chinese University of Hong Kong, Hong Kong, China.

Currently, there is no effective molecular-based therapy for triple-negative breast cancer (TNBC). Canonical transient receptor potential isoform 3 (TRPC3) was previously shown to be upregulated in breast cancer biopsy tissues when compared to normal breast tissues. However, the biological role of TRPC3 in breast cancer still remains to be elucidated. Read More

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https://www.mdpi.com/2072-6694/11/4/558
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http://dx.doi.org/10.3390/cancers11040558DOI Listing
April 2019
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Trastuzumab-Modified Gold Nanoparticles Labeled with At as a Prospective Tool for Local Treatment of HER2-Positive Breast Cancer.

Nanomaterials (Basel) 2019 Apr 18;9(4). Epub 2019 Apr 18.

Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland.

Highly localized radiotherapy with radionuclides is a commonly used treatment modality for patients with unresectable solid tumors. Herein, we propose a novel α-nanobrachytherapy approach for selective therapy of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This uses local intratumoral injection of 5-nm-diameter gold nanoparticles (AuNPs) labeled with an α-emitter (At), modified with polyethylene glycol (PEG) chains and attached to HER2-specific monoclonal antibody (trastuzumab). Read More

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http://dx.doi.org/10.3390/nano9040632DOI Listing

PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Biomarker Research Program Center, Houston Methodist Research Institute, Houston, TX 77030, USA.

Intratumoral infiltration of myeloid-derived suppressor cells (MDSCs) is known to promote neoplastic growth by inhibiting the tumoricidal activity of T cells. However, direct interactions between patient-derived MDSCs and circulating tumors cells (CTCs) within the microenvironment of blood remain unexplored. Dissecting interplays between CTCs and circulatory MDSCs by heterotypic CTC/MDSC clustering is critical as a key mechanism to promote CTC survival and sustain the metastatic process. Read More

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http://dx.doi.org/10.3390/ijms20081916DOI Listing

Beyond PD-L1 Markers for Lung Cancer Immunotherapy.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland.

Immunotherapy using immune checkpoints inhibitors has become the standard treatment for first and second line therapy in patients with non-small cell lung cancer (NSCLC). However, proper predictive factors allowing precise qualification of NSCLC patients for immunotherapy have not been developed so far. Expression of PD-L1 on tumor cells and tumor mutation burden are used in qualification of patients to first line therapy with pembrolizumab and atezolizumab in combination with ipilimumab in prospective clinical trials. Read More

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https://www.mdpi.com/1422-0067/20/8/1915
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http://dx.doi.org/10.3390/ijms20081915DOI Listing
April 2019
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Altered Expression and Localization of Tumor Suppressive E3 Ubiquitin Ligase SMURF2 in Human Prostate and Breast Cancer.

Cancers (Basel) 2019 Apr 18;11(4). Epub 2019 Apr 18.

Laboratory of Molecular and Cellular Cancer Biology, Azrieli Faculty of Medicine, Bar-Ilan University, 1311502 Safed, Israel.

SMURF2, an E3 ubiquitin ligase and suggested tumor suppressor, operates in normal cells to prevent genomic instability and carcinogenesis. However, the mechanisms underlying SMURF2 inactivation in human malignancies remain elusive, as is rarely found mutated or deleted in cancers. We hypothesized that SMURF2 might have a distinct molecular biodistribution in cancer versus normal cells and tissues. Read More

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https://www.mdpi.com/2072-6694/11/4/556
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http://dx.doi.org/10.3390/cancers11040556DOI Listing
April 2019
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Role of a Structured Physical Activity Pathway in Improving Functional Disability, Pain and Quality of Life in a Case of Breast and Gynecological Cancer Survivorship.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, 50134 Florence, Italy.

Physical activity (PA) interventions can improve physical functioning, treatment-related symptoms and quality of life (QoL) in cancer survivors. Most investigations have been conducted in breast cancer survivors, while studies on PA interventions in gynecological cancer survivors are scant. Here, we report for the first time the possible benefits of a structured PA pathway (i. Read More

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http://dx.doi.org/10.3390/jcm8040531DOI Listing

Co-assembled Ca Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery.

Mol Ther Nucleic Acids 2019 Mar 28;16:378-390. Epub 2019 Mar 28.

Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; The Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address:

Successful gene therapy requires the development of suitable carriers for the selective and efficient delivery of genes to specific target cells, with minimal toxicity. In this work, we present a non-viral vector for gene delivery composed of biocompatible materials, CaCl, plasmid DNA and the semi-synthetic anionic biopolymer alginate sulfate (AlgS), which spontaneously co-assembled to form nanoparticles (NPs). The NPs were characterized with a slightly anionic surface charge (Zeta potential [ζ] = -14 mV), an average size of 270 nm, and their suspension was stable for several days with no aggregation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21622531193006
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http://dx.doi.org/10.1016/j.omtn.2019.03.006DOI Listing
March 2019
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Methylglyoxal in combination with 5-Fluorouracil elicits improved chemosensitivity in breast cancer through apoptosis and cell cycle inhibition.

Biomed Pharmacother 2019 Apr 16;114:108855. Epub 2019 Apr 16.

Dept. of Biophysics, Bose Institute, P 1/12, CIT Scheme VII M, Kolkata, 700 054, WB, India; Dept. of Chemistry, Institute of Applied Science & Humanities GLA University Mathura, 17km Stone, NH-2, Mathura-Delhi Road, Mathura, 281 406, UP, India. Electronic address:

The anti-carcinogenic effect of Methylglyoxal (MG) is well established. It generally targets malignant cells by affecting glycolysis and mitochondrial respiration with minimum or no toxicity to normal cells. In an initial study we have reported that MG can synergistically act with 5-Fluorouracil (5-FU) to decreases the number of MCF-7 breast cancer cells (Ghosh S, Pal A, Ray M, 2017). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108855DOI Listing

Synthesis, molecular properties and comparative docking and QSAR of new 2-(7-hydroxy-2-oxo-2H-chromen-4-yl)acetic acid derivatives as possible anticancer agents.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 7;218:248-262. Epub 2019 Apr 7.

Chemistry Department, Faculty of Science, Al-Azhar University (Boys Branch), Nasr City, Cairo, Egypt.

Novel coumarin amino acid derivatives were synthesized. The structure of synthesized compounds has established on basis of different spectral data. The optimization geometry, frontier molecular orbitals (FMOs), thermodynamic parameters and chemical reactivity, were discussed using DFT\B3LYP by 6-311G* basis set, to identify a clear view for inter and intramolecular interaction of tested compounds. Read More

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http://dx.doi.org/10.1016/j.saa.2019.02.074DOI Listing
April 2019
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Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana.

Phytochemistry 2019 Apr 16;163:38-45. Epub 2019 Apr 16.

Department of Drug Design and Pharmacology, University of Copenhagen, DK-2100, Copenhagen, Denmark. Electronic address:

Two highly oxygenated nortriterpenes, picraviane A and B, were isolated from the ethanolic extract of Picramnia glazioviana Engl. The structures were determined by analysis of HRMS and 2D NMR spectroscopic data. Single-crystal X-ray diffraction data was also obtained for picraviane B. Read More

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http://dx.doi.org/10.1016/j.phytochem.2019.03.024DOI Listing

Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma.

Bioorg Chem 2019 Mar 7;87:838-850. Epub 2019 Mar 7.

Sakarya University of Applied Sciences, Pamukova Vocational Highschool, Pamukova, Turkey.

A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the alkyl chains was synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms I, II, IX and XII were evaluated. In addition, cytotoxic effects of the synthesized compounds on renal adenocarcinoma (769P), hepatocellular carcinoma (HepG2) and breast adeno carcinoma (MDA-MB-231) cell lines were examined. While the hCA I and II isoforms were inhibited in the micromolar range, the tumor-associated isoform hCA IX and XII were inhibited in the high nanomolar range. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.03.003DOI Listing

[Too old for that? Only others believe it].

Gynecol Obstet Fertil Senol 2019 Apr 16. Epub 2019 Apr 16.

Président du CNGOF, 91 Boulevard de Sébastopol 75002 Paris, France.

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http://dx.doi.org/10.1016/j.gofs.2019.04.008DOI Listing

Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets.

Pharmacol Res 2019 Apr 16. Epub 2019 Apr 16.

Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB) Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, 781039, India. Electronic address:

In spite of billions of dollars expended on cancer research every year, the incidence rate and the mortality rate due to this widespread disease has increased drastically over the last few decades. Recent reports from the World Health Organization advocate that overall global cancer burden and deaths due to cancer are expected to double by the next decade. Synthetic drugs developed as chemotherapeutics have repeatedly shown adverse side effects and development of chemoresistance. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.04.004DOI Listing
April 2019
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Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells.

Gene 2019 Apr 16. Epub 2019 Apr 16.

School of Basic Medical Sciences, Guilin Medical University, Guilin 541004, China; Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guilin Medical University, Guilin 541004, China. Electronic address:

Previous studies report the upregulation of the secretory Rab27B small GTPase in human breast cancer, which could promote invasive growth and metastasis in estrogen receptor (ER)-positive breast cancer cells. However, there is limited evidence for its role in ER-negative breast cancer, along with the signaling pathways. Consistent with previous studies, we here confirmed that Rab27B is upregulated in breast tumor tissue in comparison with normal breast tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119193034
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http://dx.doi.org/10.1016/j.gene.2019.04.005DOI Listing
April 2019
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Androgen receptor in breast cancer: a wolf in sheep's clothing? A lesson from prostate cancer.

Semin Cancer Biol 2019 Apr 16. Epub 2019 Apr 16.

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. Electronic address:

The possibility that a receptor for androgen is expressed in Breast Cancer (BC) is fascinating given that the tumor is predominantly estrogen-dependent. The androgen receptor (AR) is emerging as a new marker and a potential new therapeutic target in the treatment of BC patients. The recent availability of selective AR inhibitors (e. Read More

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http://dx.doi.org/10.1016/j.semcancer.2019.04.002DOI Listing
April 2019
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Predictive accuracy of the breast cancer genetic risk model based on eight common genetic variants: The BACkSIDE study.

J Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava (JFMED UK), Slovakia.

Breast cancer (BC) development is caused by the interaction of environmental and genetic factors. At least 90 susceptible genetic variants with different population penetration and incidence have been associated with BC. This paper therefore analysed the individual discrimination power of 8 low penetrant common genetic variants and calculated the predictive accuracy of the genetic risk model. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01681656193012
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http://dx.doi.org/10.1016/j.jbiotec.2019.04.014DOI Listing
April 2019
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Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs).

Aging (Albany NY) 2019 Apr 19. Epub 2019 Apr 19.

Translational Medicine, School of Environment and Life Sciences, Biomedical Research Centre (BRC), University of Salford, Greater Manchester, M5 4WT, United Kingdom.

Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a dietary vitamin supplement. This approach was designed to induce a "rho-zero-like" phenotype in cancer cells. This strategy effectively results in the synergistic eradication of CSCs, using vanishingly small quantities of two antibiotics. Read More

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http://dx.doi.org/10.18632/aging.101905DOI Listing

Methyl-Hispolon from Phellinus lonicerinus (Agaricomycetes) Affects Estrogen Signals in MCF-7 Breast Cancer Cells and Premature Aging in Rats.

Int J Med Mushrooms 2019 ;21(4):381-392

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei, China; Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, China.

We studied Phellinus lonicerinus to determine the cytotoxic effect and the dual estrogenic activities of methyl-hispolon and their relation to estrogen signals in vivo and in vitro. The Glide scores of methyl-hispolon-estrogen receptor α (ERα) and methyl-hispolon-ERβ docked complexes were -7.29 kcal/mol and -6. Read More

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http://dx.doi.org/10.1615/IntJMedMushrooms.2019030355DOI Listing
January 2019

Simulating Time-Dependent Patterns of Nonadherence by Patients With Breast Cancer to Adjuvant Oral Endocrine Therapy.

JCO Clin Cancer Inform 2019 Apr(3):1-9

1 University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Nearly 40% of patients with breast cancer discontinue their adjuvant oral endocrine treatment (ET). We measured discontinuation rates of ET at a comprehensive cancer center. We then used an iterative approach to model patterns of determinants associated with discontinuation of ET. Read More

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https://ascopubs.org/doi/10.1200/CCI.18.00091
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http://dx.doi.org/10.1200/CCI.18.00091DOI Listing
April 2019
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Mammary adipose stromal cells derived from obese women reduce sensitivity to the aromatase inhibitor anastrazole in an organotypic breast model.

FASEB J 2019 Apr 19:fj201802347RRR. Epub 2019 Apr 19.

Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Aromatase inhibitors are the preferred treatment for certain women with estrogen receptor (ER)-positive breast cancer, but evidence suggests that women with obesity experience aromatase inhibitor resistance at higher rates. To compare how stromal cells derived from women who are lean or obese influence response to the aromatase inhibitor (anastrazole), we incorporated patient-derived stroma in a previously characterized MCF7-derived duct model. Coculture with adipose stromal cells enabled the metabolism of testosterone (T) to E, which induced estrogen response element activity, epithelial proliferation, and hyperplasia in MCF7 cells. Read More

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http://dx.doi.org/10.1096/fj.201802347RRRDOI Listing