2,530 results match your criteria Breast Cancer* Plastic Surgery


Sternal resection and reconstruction for metastasis due to breast cancer: the Marlex sandwich technique and implantation of a pedicled latissimus dorsi musculocutaneous flap.

J Cardiothorac Surg 2019 Apr 18;14(1):79. Epub 2019 Apr 18.

Department of Thoracic Surgery, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa, 920-0293, Japan.

Background: The treatment of hemotogenous solitary sternal metastases by breast cancer remains a controversial issue. Sternal resection for select patients might provide good long-term local control.

Case Presentation: A 63-year-old woman was admitted to our hospital with a mass at the sternum and right second to third costochondral cartilage. Read More

View Article

Download full-text PDF

Source
https://cardiothoracicsurgery.biomedcentral.com/articles/10.
Publisher Site
http://dx.doi.org/10.1186/s13019-019-0905-zDOI Listing
April 2019
1 Read

Oncoplastic breast surgery versus conventional breast-conserving surgery: a comparative retrospective study.

ANZ J Surg 2019 Apr 16. Epub 2019 Apr 16.

Department of Gynaecology and Gynaecological Oncology, Charité University Medicine Berlin, Berlin, Germany.

Background: In addition to conventional breast-conserving surgery (BCS), oncoplastic breast surgery (OBS) is an operation technique that strives simultaneously to increase oncological safety and patient's satisfaction. It is the combination of the best-proven techniques in plastic surgery with surgery for breast cancer. In a growing number of indications, OBS overcomes the limit of conventional BCS by allowing larger resection volumes while avoiding deformities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ans.15245DOI Listing

Neo-adjuvant chemotherapy does not affect the immediate postoperative complication rate after breast reconstruction.

Breast J 2019 Apr 9. Epub 2019 Apr 9.

The Department of Plastic and Reconstructive Surgery, Kaplan Medical Center, Rehovot, Israel.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/tbj.13277
Publisher Site
http://dx.doi.org/10.1111/tbj.13277DOI Listing
April 2019
2 Reads

Current surgical practices of robotic-assisted tissue repair and reconstruction.

Chin J Traumatol 2019 Feb 27. Epub 2019 Feb 27.

Department of Burn and Plastic Surgery, Xiang'an Hospital of Xiamen University, Xiamen, Fujian Province, 361100, China. Electronic address:

This paper systematically reviewed and analyzed the recent publications of robotic-assisted surgeries in the field of tissue repair and reconstruction. Surgical robots can elevate skin flap more accurately and shorten the time of tissue harvest. In addition, robotic-assisted surgery has the advantage of minimal tissue trauma and thus forms minimal scar. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjtee.2019.01.003DOI Listing
February 2019
1 Read

Evolving indications and long-term oncological outcomes of risk-reducing bilateral nipple-sparing mastectomy.

BJS Open 2019 Apr 26;3(2):169-173. Epub 2018 Nov 26.

Breast Services Division, Department of General Surgery, Cleveland Clinic Cleveland Ohio USA.

Background: Bilateral nipple-sparing mastectomy (NSM) is a technically feasible operation and is associated with excellent cosmetic outcomes. The aim of this study was to evaluate trends in patient characteristics, indications for surgery and long-term outcomes of bilateral NSM for breast cancer risk reduction over time.

Methods: A review of a single-centre experience with bilateral NSM performed between 2001 and 2017 for breast cancer risk reduction in patients without breast cancer was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bjs5.50117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433310PMC

Systematic review of therapeutic nipple-sparing skin-sparing mastectomy.

BJS Open 2019 Apr 19;3(2):135-145. Epub 2018 Dec 19.

Breast Surgical Unit, The Royal Marsden NHS Foundation Trust Sutton UK.

Background: The use of nipple-sparing mastectomy (NSM) is increasing, despite unproven oncological safety in the therapeutic setting. The aim of this systematic review was to determine the safety and efficacy of NSM compared with skin-sparing mastectomy (SSM).

Methods: A literature search of all original studies including RCTs, cohort studies and case-control studies comparing women undergoing therapeutic NSM or SSM for breast cancer was undertaken. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bjs5.50119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433323PMC

Isolation and functional characterization of a novel endogenous inverse agonist of estrogen related receptors (ERRs) from human pregnancy urine.

J Steroid Biochem Mol Biol 2019 Apr 4. Epub 2019 Apr 4.

Division of plastic surgery, Department of Surgery, Montreal, Canada; Department of Medicine, McGill University, Montreal, Canada. Electronic address:

Estrogen-receptor related receptors (ERRs) which consists of ERRα, ERRβ and ERRγ belong to the orphan nuclear receptor subfamily 3, group B (NR3B) subfamily, and are constitutively active. ERRs have been shown to actively modulate estrogenic responses, and to play an essential role in pregnancy, and are implicated in breast cancer progression. Despite intensive efforts, no endogenous ligand other than the ubiquitous sterol, cholesterol which binds ERRα, has been identified for ERRs so far. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsbmb.2019.04.001DOI Listing
April 2019
2 Reads

Repositioning antipsychotic fluphenazine hydrochloride for treating triple negative breast cancer with brain metastases and lung metastases.

Am J Cancer Res 2019 1;9(3):459-478. Epub 2019 Mar 1.

Department of Rehabilitation Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu 610041, China.

Triple negative breast cancer (TNBC) patients have a high risk of brain metastases. This deadly disease represents a major challenge for successful treatment, in part because of the poor ability of drugs to penetrate the blood-brain barrier. Antipsychotic drugs show good bioavailability in the brain, and some of them have exhibited anticancer effects in several cancer types. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448056PMC
March 2019
1 Read

Preoperative planning of lymphaticovenous anastomosis: The use of magnetic resonance lymphangiography as a complement to indocyanine green lymphography.

J Plast Reconstr Aesthet Surg 2019 Mar 2. Epub 2019 Mar 2.

Department of Plastic Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.

Background: Lymphaticovenous anastomosis (LVA) is a surgical treatment for lymphedema that requires identification and mapping of functional lymphatic channels. This technique was performed blindly for years because of the lack of suitable methods of study. Progress in imaging techniques and the introduction of Indocyanine green lymphography (ICG-L) represented a significant advancement in lymphedema management. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjps.2019.02.024DOI Listing
March 2019
2 Reads

Immediate Breast Reconstruction Does Not Have a Clinically Significant Impact on Adjuvant Treatment Delay and Subsequent Survival Outcomes.

J Breast Cancer 2019 Mar 22;22(1):109-119. Epub 2019 Jan 22.

Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Purpose: The use of immediate breast reconstruction (IBR) has been debated because it may be a causative factor in adjuvant treatment delay and may subsequently increase the probability of recurrence. We investigated whether IBR was related to adjuvant treatment delay and survival outcomes.

Methods: We retrospectively analyzed the duration from operation to adjuvant treatment administration and survival outcomes according to IBR status among patients with breast cancer who underwent mastectomy followed by adjuvant chemotherapy from January 2005 to December 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4048/jbc.2019.22.e7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438834PMC
March 2019
1 Read
1.317 Impact Factor

Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma.

Front Immunol 2019 19;10:453. Epub 2019 Mar 19.

St. John's Institute of Dermatology, School of Basic & Medical Biosciences, Guy's Hospital, King's College London, London, United Kingdom.

The immune system employs several checkpoint pathways to regulate responses, maintain homeostasis and prevent self-reactivity and autoimmunity. Tumor cells can hijack these protective mechanisms to enable immune escape, cancer survival and proliferation. Blocking antibodies, designed to interfere with checkpoint molecules CTLA-4 and PD-1/PD-L1 and counteract these immune suppressive mechanisms, have shown significant success in promoting immune responses against cancer and can result in tumor regression in many patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.00453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435047PMC
March 2019
1 Read

Staged Treatment of Chest Wall Radiation-Induced Ulcer With Negative Pressure Wound Therapy and Latissimus Dorsi Myocutaneous Flap Transplantation.

J Craniofac Surg 2019 Mar 27. Epub 2019 Mar 27.

Department of Burns and Plastic Surgery.

Chest wall ulcer induced by postmastectomy radiation therapy (PRMT) remains challenging for plastic surgeons because of the reduced blood supply, fibrosis, and impaired cellular potential in the irradiated area. In this study, chest wall ulcer was treated with negative pressure wound therapy (NPWT) and the latissimus dorsi myocutaneous (LDM) flap reconstruction in 2 stages. A retrospective study was performed on consecutive patients with chronic radiation-induced ulcers in chest wall from June 2012 to June 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SCS.0000000000005514DOI Listing
March 2019
3 Reads

Body mass index impacts infection rates in immediate autogenous breast reconstruction.

Breast Cancer Res Treat 2019 Apr 1. Epub 2019 Apr 1.

Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, 149 College Street, 5th Floor, Suite 508, Toronto, ON, M5T 1P5, Canada.

Purpose: Risk of postoperative infection following breast cancer reconstruction warrants consideration of both classic and procedure-specific risk factors. We performed a retrospective chart review of patients with breast cancer over a 10-year period that underwent reconstructive surgery to identify factors that increase risk of postoperative infection.

Methods: Rates of postoperative infection were assessed in primary (immediate or delayed, alloplastic or autogenous) and secondary reconstructive procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10549-019-05215-xDOI Listing

Volumetric change of the latissimus dorsi muscle after immediate breast reconstruction with an extended latissimus dorsi musculocutaneous flap.

Arch Plast Surg 2019 Mar 31;46(2):135-139. Epub 2019 Mar 31.

Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Yangsan, Korea.

Background: In immediate breast reconstruction using an extended latissimus dorsi musculocutaneous (eLDMC) flap, the volume of the flap decreases, which causes a secondary deformity of the breast shape. Since little research has investigated this decrease in muscle volume, the authors conducted an objective study to characterize the decrease in muscle volume after breast reconstruction using an eLDMC flap.

Methods: Research was conducted from October 2011 to November 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5999/aps.2017.01690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446034PMC
March 2019
4 Reads

Acceptance of contralateral reduction mammoplasty after oncoplastic breast conserving surgery: A semi-structured qualitative interview study.

Breast 2019 Mar 25;45:97-103. Epub 2019 Mar 25.

Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address:

Objectives: Oncoplastic breast conserving surgery (BCS) frequently induces asymmetry. Contralateral reduction mammoplasty (CRM) is therefore part of the oncoplastic approach. Our patients frequently declined CRM when offered as a second-stage procedure after the completion of adjuvant treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.breast.2019.03.008DOI Listing
March 2019
2 Reads

Discussion of preoperative mammography in women undergoing reduction mammaplasty.

Breast J 2019 Mar 28. Epub 2019 Mar 28.

Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

Purpose: Reduction mammaplasty is one of the most common procedures performed by plastic surgeons. Previous studies demonstrated that most plastic surgeons do not require preoperative mammography prior to reduction mammaplasty. The incidental discovery of malignant or high-risk lesions in breast reduction specimens may preclude the possibility of breast-conserving surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tbj.13237DOI Listing

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study.

Br J Cancer 2019 Mar 29. Epub 2019 Mar 29.

Linda McCartney Centre, Royal Liverpool and Broadgreen University Hospital, Prescot Street, Liverpool, L7 8XP, UK.

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41416-019-0438-1DOI Listing

Development and Validation of a Nipple-Specific Scale for the BREAST-Q to Assess Patient-Reported Outcomes following Nipple-Sparing Mastectomy.

Plast Reconstr Surg 2019 Apr;143(4):1010-1017

San Francisco, Calif.; Hamilton, Ontario, Canada; and New York, N.Y. From the Divisions of Plastic and Reconstructive Surgery and Breast Surgery, Department of Surgery, University of California, San Francisco; the Department of Pediatrics, McMaster University; and Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center.

Background: Nipple-sparing mastectomy and immediate reconstruction has become increasingly popular for prophylactic and therapeutic indications. Patient-reported outcomes instruments such as the BREAST-Q provide important information regarding patient satisfaction and aesthetic and functional outcomes. However, a validated patient-reported outcomes scale specifically addressing nipple-related outcomes following nipple-sparing mastectomy is not currently available. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005426DOI Listing

The role of SOX family members in solid tumours and metastasis.

Semin Cancer Biol 2019 Mar 23. Epub 2019 Mar 23.

Department of Biomedicine, Aarhus University, Wilhelm Meyers Allé 4, 8000 Aarhus C, Denmark; Department of Ophthalmology, Aarhus University Hospital, DK-8200 Aarhus C, Denmark. Electronic address:

Cancer is a heavy burden for humans across the world with high morbidity and mortality. Transcription factors including sex determining region Y (SRY)-related high-mobility group (HMG) box (SOX) proteins are thought to be involved in the regulation of specific biological processes. The deregulation of gene expression programs can lead to cancer development. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S1044579X183014
Publisher Site
http://dx.doi.org/10.1016/j.semcancer.2019.03.004DOI Listing
March 2019
5 Reads

The Role of Muscle Relaxants – Spasmolytic (Thiocochlicoside) in Postoperative Pain Management after Mastectomy and Breast Reconstruction

Asian Pac J Cancer Prev 2019 Mar 26;20(3):743-749. Epub 2019 Mar 26.

Department of Nursing, Technological Educational Institute of Athens, Athens, Greece.

Purpose: Post-operative pain after breast cancer surgery is a major problem and women undergoing mastectomy and breast reconstruction experience post-operative pain syndromes in approximately one-half of all cases. Patients who have undergone breast reconstruction after mastectomy can suffer from acute postoperative pain with moderate or strong tension. In some cases, chronic neuropathic pain syndromes may occur after surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31557/APJCP.2019.20.3.743DOI Listing
March 2019
1.500 Impact Factor

"The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety".

Plast Reconstr Surg 2019 Mar 7. Epub 2019 Mar 7.

Department of Surgery, Section of Plastic and Reconstructive Surgery, University of Michigan, Ann Arbor, Michigan.

Background: Radiotherapy plays an essential role in the oncologic management of breast cancer. However, patients who undergo radiotherapy experience significantly more wound complications during the reconstructive process. Deferoxamine is an FDA-approved iron chelator with immense potential to up-regulate angiogenesis and improve reconstructive outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005647DOI Listing
March 2019
4 Reads

Oncoplastic breast conservation occupies a niche between standard breast conservation and mastectomy - A population-based prospective audit in Scotland.

Eur J Surg Oncol 2019 Mar 15. Epub 2019 Mar 15.

Academic Unit of Surgery, University of Glasgow School of Medicine, United Kingdom; Department of Surgery, New Victoria Infirmary Glasgow, United Kingdom. Electronic address:

Introduction: The role of oncoplastic breast conservation (OBC) surgery is not fully defined in terms of whether it is equivalent to standard breast conservation (SBC), or more an alternative to mastectomy, or whether it occupies its own niche somewhere between the two. Therefore, we have carried out a population-based prospective audit of the current OBC practice in Scotland.

Methods: All patients diagnosed with breast cancer in the whole of Scotland between 01/01/2014 and 31/12/2015 were prospectively recorded within the National Managed Clinical Networks databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejso.2019.03.014DOI Listing
March 2019
1 Read

Patient-reported outcomes after breast reconstructive surgery: A prospective cross-sectional study.

Ann Med Surg (Lond) 2019 Mar 16;39:22-25. Epub 2019 Feb 16.

Department of General Surgery, Plastic and Reconstructive Surgery Unit, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Background: With advancements in and the evolution of the medical field, several methods and surgical techniques have been developed for breast reconstruction after mastectomy. Generally, we can categorize these strategies into two broad groups: autologous reconstruction and implant-based reconstruction. This study aimed to analyze the satisfaction rate between these groups, considering age, timing of breast reconstruction, body mass index (BMI), major complications, and the need for radiotherapy or chemotherapy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S20490801193000
Publisher Site
http://dx.doi.org/10.1016/j.amsu.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409383PMC
March 2019
6 Reads

Patient satisfaction with breast reconstructionusing musculocutaneous flap from latissimus dorsiversus from rectus abdominis: a cross-sectional study.

Sao Paulo Med J 2018 Nov-Dec;136(6):551-556

MD, PhD. Physician and Titular Professor, Discipline of Plastic Surgery, Universidade Federal de São Paulo (UNİFESP), São Paulo (SP), Brazil.

Background: Breast cancer is the second most frequent type of cancer worldwide and the most common type among women. The treatment for this condition has evolved over recent decades with therapeutic and technological advances. Breast reconstruction techniques using musculocutaneous flaps from the latissimus dorsi and rectus abdominis have aroused interest regarding patients' quality of life. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1516-3180.2018.032916112018DOI Listing
October 2018
1 Read

Successful treatment of breast cancer-related breast lymphedema by lymphovenous anastomosis in a male patient.

Microsurgery 2019 Mar 19. Epub 2019 Mar 19.

International Lymphedema Center, Hiroshima University Hospital, Hiroshima, Japan.

Men, as well as women may develop breast lymphedema following breast cancer treatment. Microsurgically performed lymphovenous anastomosis (LVA), an effective treatment for lymphedema of the extremities, has also been successfully applied to breast lymphedema. Here we report the first case of breast lymphedema secondary to male breast cancer, treated with supermicrosurgical LVA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/micr.30447DOI Listing
March 2019
1 Read

Dorsal Wrist Placement for Vascularized Submental Lymph Node Transfer Significantly Improves Breast Cancer-Related Lymphedema.

Plast Reconstr Surg Glob Open 2019 Feb 20;7(2):e2149. Epub 2019 Feb 20.

Division of Reconstructive Microsurgery, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan.

Background: Vascularized submental lymph node flap transfer to the wrist is an effective treatment for breast cancer-related lymphedema. Dorsal placement was hypothesized to offer superior outcomes due to favorable venous drainage; however, the flap is more visible in this position compared with the volar side and was a cosmetic concern for patients. This study compared the treatment response of breast cancer-related lymphedema with the placement of vascularized submental lymph node flaps at the wrist, between dorsal and volar recipient sites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GOX.0000000000002149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416112PMC
February 2019
1 Read

Immediate and Long-term Complications of Direct-to-implant Breast Reconstruction after Nipple- or Skin-sparing Mastectomy.

Plast Reconstr Surg Glob Open 2018 Nov 5;6(11):e1977. Epub 2018 Nov 5.

Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

Background: Traditionally, breast reconstruction options after mastectomy comprise an autologous flap or staged expander/implant reconstruction, or a combination of both. Recent introduction of skin or nipple-sparing mastectomies have led to much interest in direct-to-implant immediate breast reconstructions. We performed a retrospective review of our initial experience. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=01720096-201811000-0000
Publisher Site
http://dx.doi.org/10.1097/GOX.0000000000001977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414105PMC
November 2018
3 Reads

Bilateral prophylactic mastectomy in BRCA mutation carriers: what surgeons need to know.

Ann Ital Chir 2019 ;90:1-2

Aim of this paper is to allows to analyze a topic of great relevance and media interest such as the role of prophylactic mastectomy in healthy women with BRCA mutation proposing to the surgeons some useful informations for decision-making. Less than 15% of all breast cancers are associated with germline genetic mutations. The majority of hereditary breast tumors are due to mutations in BRCA1 and BRCA2 genes that are responsible for only one third of hereditary cases. Read More

View Article

Download full-text PDF

Source
January 2019
5 Reads

Managing keloid scars: From radiation therapy to actual and potential drug deliveries.

Int Wound J 2019 Mar 12. Epub 2019 Mar 12.

Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.

The aetiology of keloids is becoming clearer, but many questions remain, including about the most optimal treatment. Current therapies include surgical excision, radiotherapy, and various pharmaceutical drugs. However, none of these drugs are keloid-specific. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/iwj.13104DOI Listing

Accurate Nipple Areolar Positioning in Nipple-sparing Mastectomy Reconstruction.

Plast Reconstr Surg Glob Open 2019 Jan 14;7(1):e2064. Epub 2019 Jan 14.

Department of Plastic and Reconstructive Surgery, Virginia Commonwealth University, Richmond, Va.

Nipple-sparing mastectomy continues to grow in popularity as oncologic indications for preserving the nipple areolar complex have become less stringent and more patients with genetic predispositions to breast cancer seek aesthetically superior prophylactic mastectomy reconstructions. Nonetheless, nipple malposition remains a common and disturbing complication. This article proposes several anatomic variations that predispose to nipple malposition and a strategy to avoid it through a reliable, easily reproducible method of preoperative marking and intraoperative stabilization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GOX.0000000000002064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382234PMC
January 2019

100 Steps of a DIEP Flap-A Prospective Comparative Cohort Series Demonstrating the Successful Implementation of Process Mapping in Microsurgery.

Plast Reconstr Surg Glob Open 2019 Jan 15;7(1):e2016. Epub 2019 Jan 15.

St Andrew's Centre for Plastic Surgery and Burns, Broomfield Hospital, Mid Essex Hospital Services NHS Trust, Chelmsford, Essex, United Kingdom.

Background: The demand to improve the efficiency of microsurgical breast reconstruction is driven by increasing number of breast cancer and risk reducing cases, and the concurrent requirement for hospitals to cut costs. Businesses have successfully used process mapping as a tool to improve efficiency; however, process mapping has been sparsely used in surgery. This prospective cohort study has used process mapping to break down the individual components of a deep inferior epigastric artery perforator (DIEP) flap operation into a template of 100 streamlined steps. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/GOX.0000000000002016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382232PMC
January 2019
1 Read

Poor Access to Breast Reconstruction: A Geographical Shortage of Plastic Surgeons Relative to Breast Surgeons in the United States.

Ann Plast Surg 2019 Apr;82(4S Suppl 3):S256-S258

Department of Surgical Oncology, Avera Medical Group Comprehensive Breast Care, Sioux Falls, SD.

Background: Breast cancer surgery involves removal of cancer performed by a breast surgeon and reconstruction performed by a plastic surgeon. Historically, many women have not undergone breast reconstruction surgery (BRS), with current literature suggesting that geographic barriers may play a role. Our objective was to determine if there is a geographic shortage of plastic surgeons in the United States and to assess for trends in access to BRS for rural, suburban, and urban populations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SAP.0000000000001846DOI Listing
April 2019
1 Read

Malignant and High-Risk Lesions in the Contralateral Breast Symmetry Mastopexy and Reduction Specimens When Performing Large-Volume Displacement Oncoplastic Surgery.

Ann Plast Surg 2019 Apr;82(4S Suppl 3):S185-S191

Department of Surgery, Tufts Medical Center, Boston, MA.

Background: Large-volume displacement oncoplastic surgery using mastopexy/reduction mammaplasty designs is becoming increasingly popular in breast cancer surgery. A contralateral symmetry operation using similar mastopexy or breast reduction designs is also commonly performed by the plastic surgeon. Our goal was to analyze contralateral symmetry specimens to review the prevalence of high-risk or malignant lesions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SAP.0000000000001910DOI Listing

Lateral thoracoaxillar dermal-fat flap for breast conserving surgery: the changes of the indication and long-term results.

Breast Cancer 2019 Mar 7. Epub 2019 Mar 7.

Department of Plastic Surgery, Yamanashi Prefectural Central Hospital, Fujimi1-1-1, Kofu, Yamanashi, 400-8506, Japan.

Background: Oncoplastic breast conserving surgery had been challenged to achieve both of local control and the cosmetic appearance of preserved breast. We developed the lateral thoracoaxillar dermal-fat flap (LTDF) as an oncoplastic procedure to fill the defect of breast-conserving surgery in 1999.

Methods: A total of 2338 breast cancer patients underwent surgery from January, 2000 to December, 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12282-019-00959-2DOI Listing

Comparison of venous couplers versus hand-sewn technique in free flap breast reconstruction.

Ann Chir Plast Esthet 2019 Apr 5;64(2):150-156. Epub 2018 Dec 5.

Department of Plastic and Reconstructive Surgery, Centre Hospitalier de l'Université de Montréal (CHUM), 850, Rue Saint-Denis, Montréal, QC H2X 0A9, Canada. Electronic address:

Introduction: Despite positive outcomes reported in the literature, some surgeons remain reluctant to the systematic use of venous couplers in free flap tissue transfer. In our institution, the use of the coupler devices for venous anastomosis in free flap breast reconstruction has yet to be adopted by all surgeons. The purpose of the study was to compare postoperative outcomes of coupler-assisted venous anastomoses with hand-sewn techniques in free flap breast reconstruction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.anplas.2018.10.002DOI Listing
April 2019
2 Reads

Frequency and risk factors for arm lymphedema after multimodal breast-conserving treatment of nodal positive breast Cancer - a long-term observation.

Radiat Oncol 2019 Mar 7;14(1):39. Epub 2019 Mar 7.

Department of Radiation Oncology, Hannover Medical School (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

Background: Arm-lymphedema is a major complication after breast cancer. Recent studies demonstrate the validity of predicting Breast Cancer Related Lymphedema (BCRL) by self-reports. We aimed to investigate the rate of BCRL and its risk factors in the long-term using self-reported symptoms. Read More

View Article

Download full-text PDF

Source
https://ro-journal.biomedcentral.com/articles/10.1186/s13014
Publisher Site
http://dx.doi.org/10.1186/s13014-019-1243-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407279PMC
March 2019
6 Reads

The use of acellular dermal matrix in breast reconstruction: evolution of techniques over 2 decades.

Gland Surg 2019 Feb;8(1):3-10

Division of Plastic and Reconstructive Surgery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Acellular dermal matrices (ADMs) are biotechnologically derived tissues that have become a cornerstone of implant-based breast reconstruction over the last 2 decades. Their use in both dual-plane and prepectoral approaches have provided greater soft tissue coverage and implant support with good cosmetic outcomes and low rates of complication. This review describes the evolution of notable ADM-assisted surgical techniques that have advanced the field and broadened implant-based reconstructive options. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/gs.2018.10.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378261PMC
February 2019

Short-term cost-effectiveness of one-stage implant-based breast reconstruction with an acellular dermal matrix versus two-stage expander-implant reconstruction from a multicentre randomized clinical trial.

Br J Surg 2019 Apr 5;106(5):586-595. Epub 2019 Mar 5.

Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Centre, Amsterdam, the Netherlands.

Background: Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure and its economic impact is significant. This study aimed to analyse whether a direct one-stage IBBR with use of an acellular dermal matrix (ADM) is more cost-effective than two-stage (expander-implant) breast reconstruction.

Methods: The BRIOS (Breast Reconstruction In One Stage) study was an open-label multicentre RCT in which women scheduled for skin-sparing mastectomy and immediate IBBR were randomized between one-stage IBBR with ADM or two-stage IBBR. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bjs.11102DOI Listing
April 2019
1 Read

Expanding the use of internal mammary artery perforators as a recipient vessel in free tissue transfer: An anatomical analysis by computed tomography angiography in breast cancer patients.

Microsurgery 2019 Mar 4. Epub 2019 Mar 4.

Department of Plastic and Reconstructive Surgery, Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, South Korea.

Background: The internal mammary artery (IMA) perforator has assumed recent prominence as recipient vessels in free autologous breast reconstruction. However, anatomical understanding is unclear, due to limited cadaver and clinical studies. We evaluated the usability of these vessels by evaluating perforator size, dominance, laterality, interspace location, and relationship with breast volume. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/micr.30446
Publisher Site
http://dx.doi.org/10.1002/micr.30446DOI Listing
March 2019
3 Reads
2.421 Impact Factor

Breast-Contour-Preserving Procedure as a Multidisciplinary Parameter of Esthetic Outcome in Breast Cancer Treatment in The Netherlands.

Ann Surg Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, Diakonessenhuis Utrecht, Utrecht, The Netherlands.

Background: The rate of breast-conserving surgery (BCS) is used as an esthetic outcome parameter, while other treatments contribute also, such as neoadjuvant chemotherapy (NAC) enabling BCS or immediate breast reconstruction (IBR). This study explores these efforts to preserve the patient's breast contour.

Patients And Methods: All patients who underwent surgery for invasive breast cancer in The Netherlands between January 2011 and December 2015 were selected from the Dutch national breast cancer audit (n = 61,309). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-019-07265-3DOI Listing
March 2019
3.930 Impact Factor

Surgical delay may extend the indications for nipple-sparing mastectomy: A multicentric study.

Eur J Surg Oncol 2019 Feb 14. Epub 2019 Feb 14.

Department of Surgery, San Giovanni-Addolorata Hospital, Via dell'Amba Aradam 9, 00199, Rome, Italy.

Introduction: Nipple-sparing mastectomy (NSM) is considered an oncologically sound procedure but necrosis of the nipple-areola complex (NAC) or skin flaps is a concern, particularly in the presence of risk factors. To increase the indications for NSM and decrease such complications, different procedures of "surgical delay" (SD) have been described.

Materials And Methods: A retrospective analysis of patients who underwent SD for NSM at four Italian Breast Centers from 2014 to 2017 was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejso.2019.02.014DOI Listing
February 2019
1 Read

Postmastectomy upper limb lymphedema: Combined vascularized lymph node transfer and scar release with fat graft expedites surgical and patients' related outcomes. A retrospective comparative study.

J Plast Reconstr Aesthet Surg 2019 Feb 10. Epub 2019 Feb 10.

Division of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, University of Bari, 11, Piazza Giulio Cesare, Bari 70124, Italy.

Introduction: Lymphedema resulting from breast cancer treatment is a chronic condition that can significantly compromise quality of life. Several works have documented the efficacy of vascularized lymph node flap transfer (VLNT) for the treatment of advanced-stage lymphedema. Given that the axillary scar may contribute to the patient's existing lymphedema, the authors assumed that combining VLNT and scar release with fat graft could be an effective strategy of treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjps.2019.01.029DOI Listing
February 2019
5 Reads

CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression.

Plast Reconstr Surg 2019 03;143(3):747-756

Durham, N.C. From Duke University School of Medicine, the Departments of Dermatology and Pathology, and the Division of Plastic and Reconstructive Surgery, Duke University.

Background: The tumor microenvironment within the breast is rich in adipose elements. The interaction between adipose cells and breast cancer is poorly understood, particularly as it pertains to patients with genetic susceptibility to breast cancer. This study focuses on the phenotype of human adipose-derived stem cells with the BRCA1 mutation and the effect they may have on breast cancer cell behavior. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400326PMC
March 2019
1 Read
2.993 Impact Factor

The Ideal Nipple Reconstruction Shield.

Plast Reconstr Surg 2019 03;143(3):698-699

London, United Kingdom From the Department of Plastic and Reconstructive Surgery, Guys & St Thomas' Hospital.

Reconstruction of the nipple-areola complex is the culmination of a long road for patients who have suffered breast cancer. The postoperative dressing of the reconstructive nipple must protect it from mechanical forces, trauma, and infection. A broad array of dressings has been used for the reconstructed nipple. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005318DOI Listing
March 2019
5 Reads

Utility of Two Surgical Techniques Using a Lateral Intercostal Artery Perforator Flap after Breast-Conserving Surgery: A Single-Center Retrospective Study.

Plast Reconstr Surg 2019 03;143(3):477e-487e

Daegu, Republic of Korea From the Departments of Plastic and Reconstructive Surgery and Surgery, School of Medicine, Kyungpook National University.

Background: Immediate partial breast reconstruction after breast-conserving surgery has become a new paradigm in treating breast cancer. Among the volume replacement techniques used for small to moderate-sized breasts, the perforator flap method has many advantages. The authors present anatomical studies and two surgical techniques using lateral intercostal artery perforator flaps. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005374DOI Listing
March 2019
15 Reads

Barriers of Access to Breast Reconstruction: A Systematic Review.

Plast Reconstr Surg 2019 03;143(3):465e-476e

Toronto and Kingston, Ontario, Canada From the Division of Plastic and Reconstructive Surgery, Toronto General Hospital; the Queen's University School of Medicine; the University Health Network; and the Institute of Health Policy Management and Evaluation, Dalla Lana School of Public Health, University of Toronto.

Background: The purpose of this systematic review was to comprehensively summarize barriers of access to breast reconstruction and evaluate access using the Penchansky and Thomas conceptual framework based on the six dimensions of access to care.

Methods: The authors performed a systematic review that focused on (1) breast reconstruction, (2) barriers, and (3) breast cancer. Eight databases (i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PRS.0000000000005313DOI Listing
March 2019
3 Reads
2.993 Impact Factor

Methylation of progesterone receptor isoform A promoter in normal breast tissue: An epigenetic link between early age at menarche and risk of breast cancer?

J Cell Biochem 2019 Feb 28. Epub 2019 Feb 28.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Emerging evidence indicates that some altered patterns of methylation that occur in breast tumors may also be found in breast tissue of healthy women in relation to the breast cancer (BC) risk factors. Progesterone receptor (PR) isoform α is a crucial regulator of breast hormone responsiveness and its hypermethylation plays an important role in the initiation and development of breast tumors. However, such a methylation change in healthy women and its link with the different risk factors has not yet been investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcb.28505DOI Listing
February 2019
2 Reads
3.263 Impact Factor

Adipose‑derived mesenchymal stem cells exhibit tumor tropism and promote tumorsphere formation of breast cancer cells.

Oncol Rep 2019 Apr 15;41(4):2126-2136. Epub 2019 Feb 15.

Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China.

Mesenchymal stem cells reportedly have a marked effect on tumor growth or suppression. However, it remains uncertain whether adipose‑derived mesenchymal stem cells (ADSCs) from grafted fat can contribute to breast cancer growth and recurrence. In the present study, interactions between ADSCs and MCF‑7 breast cancer cells were evaluated in a Matrigel co‑culture system and in an in vivo nude mouse model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/or.2019.7018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412463PMC
April 2019
2 Reads

Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1 TAMs.

Sci Rep 2019 Feb 28;9(1):3172. Epub 2019 Feb 28.

Department of Basic Oncology, Hacettepe University Cancer Institute, Sihhiye, 06100, Ankara, Turkey.

Fibroblasts turn into cancer associated fibroblasts (CAFs) in the tumour microenvironment. CAFs have recently attracted attention for their function as a regulator of immune cell recruitment and function in addition to their tumour-promoting roles. In this study, we aimed to determine the role of CAFs on monocyte recruitment and macrophage polarization in breast cancer. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-39553-z
Publisher Site
http://dx.doi.org/10.1038/s41598-019-39553-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395633PMC
February 2019
6 Reads