2,959 results match your criteria Breast Cancer* Plastic Surgery


Oncoplastic Surgery in the Management of Breast Cancer.

J Clin Oncol 2020 May 22:JCO1902795. Epub 2020 May 22.

Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1200/JCO.19.02795DOI Listing

The Reconstruction after a Giant Phyllodes Tumor Resection Using a DIEP Flap.

Plast Reconstr Surg Glob Open 2020 Apr 27;8(4):e2760. Epub 2020 Apr 27.

Department of Plastic and Reconstructive Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

A phyllodes tumor of the breast is a rare neoplasm, accounting for 0.3%-1% of all breast cancers. The size is 4-5 cm on average but sometimes the tumor grows more and involves the entire breast. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209875PMC

Intraoperative Near-infrared Spectroscopy Correlates with Skin Flap Necrosis: A Prospective Cohort Study.

Plast Reconstr Surg Glob Open 2020 Apr 22;8(4):e2742. Epub 2020 Apr 22.

Department of Surgery and Oncology, Foothills Medical Centre, Calgary, AB, Canada.

Background: Skin flap necrosis (SFN) is a morbid complication that is disfiguring, leads to acute and chronic wound issues, often requires further surgery, and can delay adjuvant chemotherapy. Although most surgeons rely on the clinical examination, near-infrared (NIR) spectroscopy can extrapolate tissue oxygenation and may serve as an important tool to assess flap perfusion intraoperatively. This cohort study was undertaken to evaluate the capacity of NIR spectroscopy to detect clinically relevant differences in tissue perfusion intraoperatively. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209868PMC

Impact of contemporary therapy- concepts on surgical morbidity in breast cancer patients: A retrospective single center analysis of 829 patients.

Eur J Surg Oncol 2020 Apr 27. Epub 2020 Apr 27.

Breast Health Center, Department of Surgery, Ordensklinikum- Sisters of Charity, 4020, Linz, Austria; Breast Health Center and Comprehensive Cancer Center Medical University, 1090, Vienna, Austria. Electronic address:

Introduction: Morbidity after breast cancer surgery remains low with revision surgery below 5%. This retrospective monocentric study investigates whether new methods like neoadjuvant chemotherapy (nCT), oncoplastic surgery (OPS) or intraoperative radiotherapy (IORT) affect overall morbidity. In addition, we sought to determine a possible effect of morbidity on oncologic outcome. Read More

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http://dx.doi.org/10.1016/j.ejso.2020.04.034DOI Listing

Re-augmentation of the Axilla Using a Turn-Over Flap - a New Approach for the Surgical Treatment of Secondary Lymphedema After Breast Cancer.

Geburtshilfe Frauenheilkd 2020 May 18;80(5):526-531. Epub 2020 May 18.

Department for Women's Health, University of Tübingen, Tübingen, Germany.

Scarring and volume reduction of the axillary space resulting in persistent lymphedema is a side effect of axillary treatment in breast cancer patients. The aim of this paper is to describe the reduction of lymphedema achieved with a turnover flap. Between October 2016 and May 2018, five patients with grade 2 lymphedema following breast cancer therapy underwent reconstructive surgery with a turnover flap. Read More

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http://dx.doi.org/10.1055/a-1063-6310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234824PMC

Use of bilateral prophylactic nipple-sparing mastectomy in patients with high risk of breast cancer.

Br J Surg 2020 May 20. Epub 2020 May 20.

Breast Service, Department of Surgery, New York, USA.

Background: Nipple-sparing mastectomy (NSM) is being performed increasingly for risk reduction in high-risk groups. There are limited data regarding complications and oncological outcomes in women undergoing bilateral prophylactic NSM. This study reviewed institutional experience with prophylactic NSM, and examined the indications, rates of postoperative complications, incidence of occult malignant disease and subsequent breast cancer diagnosis. Read More

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http://dx.doi.org/10.1002/bjs.11616DOI Listing

Breast cancer in women: a descriptive analysis of the national cancer database.

Acta Biomed 2020 May 11;91(2):332-341. Epub 2020 May 11.

Division of Plastic Surgery and Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, Florida.

Background And Aim Of The Work: Breast cancer is the most common cancer in women in the United States. National Cancer Database (NCDB) is one of the largest tumor databases of the United States. This study aimed to evaluate the features of breast cancer in women from a large updated database. Read More

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http://dx.doi.org/10.23750/abm.v91i2.8399DOI Listing

The basics of ultrasound elastography for diagnosis, assessment, and staging breast cancer-related lymphedema: a systematic review of the literature.

Gland Surg 2020 Apr;9(2):589-595

Department of Surgery, Mayo Clinic, Jacksonville, FL, USA.

Breast cancer-related lymphedema (BCRL) incidence has been increasing overtime. Currently, there is not a preferred imaging tool for diagnosis, staging, and assessment of the disease. We aim to review the use of ultrasound elastography (UE) in BCRL patients. Read More

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http://dx.doi.org/10.21037/gs.2020.02.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225463PMC

Single-stage VASER-assisted liposuction and lymphatico-venous anastomoses for the treatment of extremity lymphedema: a case series and systematic review of the literature.

Gland Surg 2020 Apr;9(2):545-557

Department of Plastic and Reconstructive Surgery, Mayo Clinic, FL, USA.

Background: A paradigm shift towards the use of combined physiological and excisional surgical approaches for the treatment of lymphedema is permeating the surgical practice worldwide. We describe a single-stage surgical approach combining-vaser assisted liposuction (VAL) and lymphatico-venous anastomoses (LVA) for the treatment of extremity-lymphedema.

Methods: Between March 2018 and March 2019, a retrospective review of patients with extremity-lymphedema stage IIb-III International Society of Lymphology who underwent the combined technique was done. Read More

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http://dx.doi.org/10.21037/gs.2020.01.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225499PMC

Lymphaticovenular anastomosis for breast cancer-related upper extremity lymphedema: a literature review.

Gland Surg 2020 Apr;9(2):539-544

Department of Surgery, Mayo Clinic, Jacksonville, FL, USA.

Breast cancer-related lymphedema is a long-term condition that affects almost half of breast cancer survivors. Clinical studies have looked at the benefits of lymphaticovenular anastomosis (LVA) for the treatment of upper extremities lymphedema after breast cancer, however, there is still controversy if it improves lymphedema. This study aimed to analyze the studies and outcomes related to LVA for breast cancer-related lymphedema. Read More

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http://dx.doi.org/10.21037/gs.2020.03.41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225471PMC

Gastroepiploic vascularized lymph node transfer for the treatment of extremity lymphedema: comparison between middle and distal inset.

Gland Surg 2020 Apr;9(2):528-538

Center for Regenerative Medicine, Mayo Clinic, Rochester, MN, USA.

Background: Middle and distal insets of gastroepiploic vascularized lymph node transfer (GE-VLNT) for extremity lymphedema have been described. However, there has been no prior comparison of surgical or patient-reported outcomes between these techniques. We analyzed the outcomes between both insets in patients with extremity lymphedema. Read More

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http://dx.doi.org/10.21037/gs.2020.02.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225493PMC

Lymph node transfer combined with deep inferior epigastric perforators and transverse rectus abdominis myocutaneous procedures: a systematic review.

Gland Surg 2020 Apr;9(2):521-527

Department of Surgery, Mayo Clinic, Jacksonville, FL, USA.

The surgical treatment of lymphedema can be conducted alone or in combination with microsurgical autologous breast reconstruction. We performed a systematic review of the literature at PubMed database regarding autologous breast reconstruction for deep inferior epigastric perforators (DIEP) or muscle-sparing transverse rectus abdominis myocutaneous (ms-TRAM) and vascularized lymph node transfer (VLNT) in patients with lymphedema following breast cancer surgery. We hypothesized that autologous breast reconstruction combined with VLNT has positive outcomes. Read More

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http://dx.doi.org/10.21037/gs.2020.02.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225473PMC

Surgical management of lymphedema: a review of current literature.

Gland Surg 2020 Apr;9(2):503-511

Division of Plastic and Reconstructive Surgery, Yale University School of Medicine, New Haven, CT, USA.

Lymphedema may be characterized by a progressive clinical course and limitations in improvement despite multi-modality treatment. In westernized countries, it most commonly presents as an undesirable complication of cancer treatment, particularly breast cancer. In the past several decades, surgical treatments for lymphedema have advanced, alongside developments in microsurgery. Read More

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http://dx.doi.org/10.21037/gs.2020.03.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225501PMC

Distant myonecrosis by atraumatic infection in a patient with metastatic breast cancer.

IDCases 2020 5;20:e00784. Epub 2020 May 5.

Division of Plastic Surgery, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA.

is an anaerobic, gram-positive bacillus known to cause myonecrosis, also known as gas gangrene, a life-threatening necrotizing soft tissue infection. Though it accounts for just 1 % of all infections attributable to spp., is a highly virulent and aggressive pathogen. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218154PMC

Ethnic variability in post-mastectomy breast reconstruction in Counties Manukau District Health Board in 2017: a retrospective review.

ANZ J Surg 2020 May 14. Epub 2020 May 14.

Department of General Surgery, Middlemore Hospital, Auckland, New Zealand.

Background: Post-mastectomy breast reconstruction (PMBR) is associated with greater quality of life and psychological well-being. However, rates of PMBR may not be equivalent across all ethnicities which contributes to disparities in health outcomes.

Methods: A retrospective review of patients diagnosed with breast cancer between 1 January and 31 December 2017 at Counties Manukau District Health Board (CMDHB) was performed. Read More

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http://dx.doi.org/10.1111/ans.15894DOI Listing

Synchronous Multiple Breast Cancers-Do We Need to Reshape Staging?

Medicina (Kaunas) 2020 May 11;56(5). Epub 2020 May 11.

Faculty of General Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.

Current recommendations and treatment regimens in breast cancer are a reflection of its heterogeneity on multiple levels including histological subtypes, grading, molecular profiling, and numerous prognostic indices. Although based on extensive research, current guidelines are not explicit in the case of surgical specimens showing various degrees of mismatch between different parts of the same tumor and even more so between multicentric lesions. Synchronous breast cancer is the ideal prototype for studying inter- and intra-tumoral heterogeneity, therefore we envisaged that a study on patients with multicentric and multifocal lesions could contribute to the reshaping of the staging, prognosis, and treatment of breast malignancies. Read More

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http://dx.doi.org/10.3390/medicina56050230DOI Listing

Becker Implant Intracapsular Rupture with Contralateral Axillary Silicone Lymphadenopathy in an Asymptomatic Patient: A Case Report and Literature Review.

Cureus 2020 Apr 11;12(4):e7638. Epub 2020 Apr 11.

Plastic Surgery, Beaumont Health, Royal Oak, USA.

Silicone gel implants are widely used for cosmetic and reconstructive breast surgery. There has been a paradigm shift with increased utilization of implant-based breast reconstruction compared to autologous reconstruction in the United States over the past couple of decades. Implant rupture is a known complication of silicone gel implants with variable incidence and increased propensity with the age of the implant. Read More

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http://dx.doi.org/10.7759/cureus.7638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216309PMC

CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions.

Cell Death Dis 2020 May 12;11(5):358. Epub 2020 May 12.

Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, No. 188, Shizi Street, Gusu District, 215006, Suzhou, Jiangsu, China.

Emerging evidence has revealed that aberrantly expressed circular RNAs (circRNAs) play vital roles in tumorigenesis and progression of diverse human malignancies. Although an existing literature has elucidated the regulatory role of circZNF609 in breast cancer, the crucial function that circZNF609 exerted on hepatocellular carcinoma (HCC) remains unclear. Herein, we determined to explore the molecular mechanism of circZNF609 in HCC. Read More

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http://dx.doi.org/10.1038/s41419-020-2441-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217914PMC

Real-Time Visualization of the Mascagni-Sappey Pathway Utilizing ICG Lymphography.

Cancers (Basel) 2020 May 8;12(5). Epub 2020 May 8.

Division of Plastic and Reconstructive Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Background: Anatomic variations in lymphatic drainage pathways of the upper arm may have an important role in the pathophysiology of lymphedema development. The Mascagni-Sappey (M-S) pathway, initially described in 1787 by Mascagni and then again in 1874 by Sappey, is a lymphatic drainage pathway of the upper arm that normally bypasses the axilla. Utilizing modern lymphatic imaging modalities, there is an opportunity to better visualize this pathway and its potential clinical implications. Read More

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http://dx.doi.org/10.3390/cancers12051195DOI Listing

Annual report of the Japanese Breast Cancer Society registry for 2016.

Breast Cancer 2020 May 11. Epub 2020 May 11.

Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8606, Japan.

The Japanese Breast Cancer Society (JBCS) registry began data collection in 1975, and it was integrated into National Clinical Database in 2012. As of 2016, the JBCS registry contains records of 656,896 breast cancer patients from more than 1400 hospitals throughout Japan. In the 2016 registration, the number of institutes involved was 1422, and the total number of patients was 95,870. Read More

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http://dx.doi.org/10.1007/s12282-020-01081-4DOI Listing

Investigation of the adolescent female breast transcriptome and the impact of obesity.

Breast Cancer Res 2020 May 11;22(1):44. Epub 2020 May 11.

Clinical Research Branch, National Institute of Environmental Health Sciences, 111 TW Alexander Drive, MD A2-03, Research Triangle Park, NC, 27709, USA.

Background: Early life environmental exposures affect breast development and breast cancer risk in adulthood. The breast is particularly vulnerable during puberty when mammary epithelial cells proliferate exponentially. In overweight/obese (OB) women, inflammation increases breast aromatase expression and estrogen synthesis and promotes estrogen-receptor (ER)-positive breast cancer. Read More

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http://dx.doi.org/10.1186/s13058-020-01279-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216667PMC

Anemia and perioperative mortality in non-cardiac surgery patients: a secondary analysis based on a single-center retrospective study.

BMC Anesthesiol 2020 May 11;20(1):112. Epub 2020 May 11.

Department of Breast thyroid surgery, Shenzhen Breast Cancer Research and Treatment Research Center, Peking University Shenzhen Hospital, 1120 Lianhua Road, Futian District, Shenzhen, 518000, Guangdong, China.

Background: Evidence regarding the relationship between anemia and perioperative prognosis is controversial. The study was conducted to highlight the specific relationship between anemia and perioperative mortality in non-cardiac surgery patients over 18 years of age.

Methods: This study was a retrospective analysis of the electronic medical records of 90,784 patients at the Singapore General Hospital from January 1, 2012 to October 31, 2016. Read More

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http://dx.doi.org/10.1186/s12871-020-01024-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212669PMC

Comprehensive Analysis of Fibroblast Growth Factor Receptor (FGFR) Family Genes in Breast Cancer by Integrating Online Databases and Bioinformatics.

Med Sci Monit 2020 May 8;26:e923517. Epub 2020 May 8.

Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, China (mainland).

BACKGROUND Fibroblast growth factor receptors (FGFRs) play vital roles in the development and progression of human cancers. This study aimed to comprehensively understand the prognostic performances of FGFR1-4 expression in breast cancer (BC) by mining databases. MATERIAL AND METHODS The levels of FGFR1-4 expression in BC were analyzed by online databases, GEPIA (Gene Expression Profiling Interactive Analysis) and UALCAN. Read More

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http://dx.doi.org/10.12659/MSM.923517DOI Listing

[The Approach of Breast Reconstruction for Breast Cancer in Our Hospital].

Gan To Kagaku Ryoho 2020 Feb;47(2):346-348

Dept. of Surgery, Kansai Medical University.

The demand for breast reconstruction is expected to increase with the currently observed increase in the number of breast cancer patients. Among the 70 patients included in the study, 59 received tissue expanders, 1 received implant, and 10 received deep inferior epigastric perforator flaps. Complications were noted in is 11 patients who received tissue expanders. Read More

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February 2020

Multidisciplinary approach to chest wall reconstruction in primary breast angiosarcoma resection.

BMJ Case Rep 2020 May 6;13(5). Epub 2020 May 6.

Department of Surgery, Galway University Hospitals, Galway, Ireland.

Angiosarcomas account for less than 1% of primary breast cancers. Typically, they occur in young women with a low-risk personal or family history. Diagnosis, resection and reconstruction require a multidisciplinary team of breast surgeons, oncologists and plastic reconstructive surgeons. Read More

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http://dx.doi.org/10.1136/bcr-2019-233156DOI Listing

Metastatic breast cancer patient perceptions of somatic tumor genomic testing.

BMC Cancer 2020 May 6;20(1):389. Epub 2020 May 6.

The Ohio State University Comprehensive Cancer Center, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.

Background: To assess metastatic breast cancer (MBC) patient psychological factors, perceptions, and comprehension of tumor genomic testing.

Methods: In a prospective, single institution, single-arm trial, patients with MBC underwent next-generation sequencing at study entry with sequencing results released at progression. Patients who completed surveys before undergoing sequencing were included in the present secondary analysis (n = 58). Read More

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http://dx.doi.org/10.1186/s12885-020-06905-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201768PMC
May 2020
3.362 Impact Factor

Capsular contracture in patients with prior breast augmentation undergoing breast conserving therapy and irradiation.

J Plast Surg Hand Surg 2020 May 7:1-8. Epub 2020 May 7.

Department of Plastic Surgery, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.

Radiation is considered to be a risk factor for developing capsular contracture in augmented women, but the studies reporting on this subject show conflicting results. In this systematic review we sought to understand the risk of capsular contracture in augmented patients with breast cancer treated with breast conserving surgery and radiotherapy. A search was conducted through PubMed for studies reporting on breast cancer, breast augmentation and radiotherapy, with capsular contracture as our primary outcome. Read More

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http://dx.doi.org/10.1080/2000656X.2020.1755299DOI Listing

Comparison of breast cancer patients who underwent partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (M + I) regarding quality of life (QOL), cosmetic outcome and survival rates.

World J Surg Oncol 2020 May 5;18(1):87. Epub 2020 May 5.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida, USA.

Purpose: The latissimus dorsi muscle has long been used in breast cancer (BC) patients for reconstruction. This study aimed to compare early stage BC patients who had partial mastectomy (PM) with mini latissimus dorsi flap (MLDF) and subcutaneous mastectomy with implant (MI) with respect to quality of life (QoL), cosmetic outcome (CO), and survival rates.

Patients And Methods: The data of patients who underwent PM + MLDF (Group 1) and M + I (Group 2) between January 2010 and January 2018 were evaluated. Read More

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http://dx.doi.org/10.1186/s12957-020-01858-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201547PMC
May 2020
1.200 Impact Factor

Adherence to treatment guidelines and survival in older women with early-stage breast cancer in Denmark 2008-2012.

Acta Oncol 2020 May 4:1-7. Epub 2020 May 4.

Department of Oncology, Odense University Hospital, Odense, Denmark.

The aims of this study were to compare patients 70 years or older with younger patients, to examine whether Danish patients with early-stage breast cancer aged 70 years or more received treatment according to guidelines, the reasons for deviating from the guidelines, and to analyze whether such deviations affected survival. From the Danish Breast Cancer Cooperative Group (DBCG) database we identified 23,247 women diagnosed with early-stage breast cancer in Denmark from 2008 to 2012. 17,391 were aged less than 70 years and 5856 were 70+ years. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1757148DOI Listing

A single-arm, prospective trial investigating the effectiveness of a non-hormonal vaginal moisturizer containing hyaluronic acid in postmenopausal cancer survivors.

Support Care Cancer 2020 May 2. Epub 2020 May 2.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: To assess the feasibility and efficacy of a non-hormonal hyaluronic acid (HLA) vaginal gel in improving vulvovaginal estrogen-deprivation symptoms in postmenopausal women with a history of hormone receptor-positive (HR+) cancer.

Methods: For this single-arm, prospective longitudinal trial, we identified disease-free patients with a history of HR+ breast cancer treated with aromatase inhibitors or HR+ endometrial cancer treated with surgery and postoperative radiation. Participants used HLA daily for the first 2 weeks, and then 3×/week until weeks 12-14; dosage was then increased to 5×/week for non-responders. Read More

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http://dx.doi.org/10.1007/s00520-020-05472-3DOI Listing

Public Interest in Textured Breast Implants Recall: A Google Trends Analysis.

Aesthetic Plast Surg 2020 Apr 30. Epub 2020 Apr 30.

Division of Plastic Surgery, Department of Surgery, Stanford University School of Medicine, 291 Campus Drive, Stanford, CA, 94305, USA.

Background: Large-scale media coverage of health care outcomes can have a profound influence on health care utilization by the general population. Google trends (GT), an online resource, allows for tracking of global search volumes as a proxy for determining public interest.

Objective: To utilize GT to characterize measurable effects on public interest in breast implant removal procedures and breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) following March 2019 FDA Advisory Committee Meeting and July 2019 public statements by the FDA and Allergan announcing the voluntary recall of BIOCELL textured breast implants. Read More

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http://dx.doi.org/10.1007/s00266-020-01724-zDOI Listing

Occult breast carcinoma is more common in women undergoing breast reduction after contralateral cancer: A systematic review and meta-analysis".

Plast Reconstr Surg 2020 Apr 28. Epub 2020 Apr 28.

Plastic and Reconstructive Surgery Department, Westmead Private Hospital, Cnr Mons Road and Darcy Road, Westmead, NSW 2145, Australia.

Background: Occult breast carcinoma is occasionally found in breast reduction specimens. Although its incidence varies widely there is a trend toward an increased incidence for women with prior history of breast cancer. We performed a systematic review and meta-analysis of occult carcinoma incidence in breast reduction specimens. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006965DOI Listing

Quadruple synchronous primary cancers in a single patient.

BMJ Case Rep 2020 Apr 29;13(4). Epub 2020 Apr 29.

Department of Plastic Surgery, Aalborg University Hospital, Aalborg, Nordjylland, Denmark.

Patients diagnosed with quadruple synchronous primary cancers are extremely rare and we present here, to the best of our knowledge, the first case report of this combination of primary cancers. A 70-year-old woman was diagnosed with cervical adenocarcinoma, melanoma on the right leg, invasive ductal cell carcinoma metastasis in the left axilla with no primary breast tumour detected and multiple basal cell carcinomas on the limbs, all within 2 months. The management was conducted in collaboration with six medical specialties. Read More

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http://dx.doi.org/10.1136/bcr-2019-233326DOI Listing

The Development of a Mobile Health App for Breast Cancer Self-Management Support in Taiwan: Design Thinking Approach.

JMIR Mhealth Uhealth 2020 Apr 30;8(4):e15780. Epub 2020 Apr 30.

Center for Patient Safety Research and Practice, Brigham and Women's Hospital, Boston, MA, United States.

Background: Evidence has shown that breast cancer self-management support from mobile health (mHealth) apps can improve the quality of life of survivors. Although many breast cancer self-management support apps exist, few papers have documented the procedure for the development of a user-friendly app from the patient's perspective.

Objective: This study aimed to investigate the information needs of Taiwanese women with breast cancer to inform the development of a self-management support mHealth app. Read More

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http://dx.doi.org/10.2196/15780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226037PMC

Predictive pharmacogenetic biomarkers for breast cancer recurrence prevention by simvastatin.

Acta Oncol 2020 Apr 30:1-7. Epub 2020 Apr 30.

Department of Clinical Epidemiology, Aarhus University Hospital/Randers Regional Hospital, Aarhus, Denmark.

Statins treat hyperlipidemia and prevent cardiovascular morbidity and mortality. Evidence suggests that they also have anti-neoplastic activity. Several studies show a reduced rate of breast cancer recurrence among lipophilic statin users (, simvastatin), motivating calls for clinical trials of statins in breast cancer patients. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1759820DOI Listing

A prospective cohort study to analyze the interaction of tumor-to-breast volume in breast conservation therapy versus mastectomy with reconstruction.

Breast Cancer Res Treat 2020 Jun 30;181(3):611-621. Epub 2020 Apr 30.

Division of Plastic & Reconstructive Surgery, Department of Surgery, Washington University School of Medicine, 1020 N. Mason, Ste 110, St. Louis, MO, USA.

Purpose: We explored the impact of the relative volume of a tumor versus the entire breast on outcomes in patients undergoing breast conservation therapy (BCT) versus mastectomy and reconstruction (M + R). We hypothesized that there would be a threshold tumor:breast ratio (TBR) below which patient-reported outcomes (PRO) would favor BCT and above which would favor M + R.

Methods: We conducted a prospective cohort study of patients with ductal carcinoma in situ (DCIS) or invasive breast cancers undergoing BCT or M + R. Read More

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http://dx.doi.org/10.1007/s10549-020-05639-wDOI Listing
June 2020
3.940 Impact Factor

Efficacy of rhomboid flap reconstruction after mastectomy for locally advanced breast cancer.

J Nippon Med Sch 2020 Apr 30. Epub 2020 Apr 30.

Division of Plastic Surgery, Saitama Cancer Center.

Background: In cases of mastectomy for locally advanced breast cancer (LABC), surgical skin flap reconstruction is sometimes required to cover large skin defects. In this study of patients with LABC, the patient group that required local flap reconstruction after mastectomy and the patient group that underwent mastectomy alone were compared to evaluate the efficacy of local, cutaneous (rhomboid) flap reconstruction after mastectomy.

Methods: Sixty-eight patients with LABC who underwent mastectomy were reviewed retrospectively. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2021_88-204DOI Listing

Quality-of-Life Outcomes in Surgical vs Nonsurgical Treatment of Breast Cancer-Related Lymphedema: A Systematic Review.

JAMA Surg 2020 Apr 29. Epub 2020 Apr 29.

Department of Plastic Surgery, Cleveland Clinic, Cleveland, Ohio.

Importance: Secondary lymphedema is a debilitating complication of breast cancer therapy and affects more than 1 in 5 breast cancer survivors. Patient-reported outcomes may be more important in predicting long-term health-related quality of life (HRQoL) than clinician-measured outcomes.

Objective: To summarize published evidence on HRQoL outcomes for vascularized lymph node transfer (VLNT) and complex decongestive therapy (CDT) used in the treatment of breast cancer-related lymphedema. Read More

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http://dx.doi.org/10.1001/jamasurg.2020.0230DOI Listing

Breast sensibility in bilateral autologous breast reconstruction with unilateral sensory nerve coaptation.

Breast Cancer Res Treat 2020 Jun 28;181(3):599-610. Epub 2020 Apr 28.

Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ, Maastricht, the Netherlands.

Background: Patient satisfaction after breast reconstruction is dependent on both esthetics and functional outcomes. In an attempt to improve breast sensibility, a sensory nerve coaptation can be performed. The aim of this study was to objectify the sensory recovery in patients who, by chance, underwent bilateral autologous breast reconstruction with one innervated and one non-innervated flap. Read More

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http://dx.doi.org/10.1007/s10549-020-05645-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220889PMC

Guidance for management of cancer surgery during the COVID-19 pandemic.

Can J Surg 2020 05;63(22):S2-S4

From the Canadian Partnership Against Cancer (Finley, Prashad, Camuso, Daly, Earle); the Canadian Network of Surgical Associations for Cancer Care (Aprikian, Ball, Bentley, Charest, Fata, Helyer, O'Connell, Moloo, Seely, Werier, Zhong); the Canadian Urological Association and the Division of Urology, Department of Surgery, McGill University, Montreal, Que. (Aprikian); the Canadian Hepato-Pancreatico-Biliary Association and the Department of Surgery, University of Calgary, Calgary, Alta. (Ball); the Society for Gynecologic Oncology of Canada and the Department of Obstetrics and Gynaecology, Dalhousie University, Halifax, NS (Bentley); the Canadian Neurosurgical Society and the Department of Neurosurgery, Dalhousie University New Brunswick, Moncton, NB (Charest); the Canadian Association of General Surgeons and the Division of General Surgery, Department of Surgery, McGill University, Montreal, Que. (Fata); the Canadian Society of Surgical Oncology and the Department of General Surgery, Dalhousie University, Halifax, NS (Helyer); the Canadian Association of Head and Neck Surgical Oncology and the Division of Otolaryngology - Head and Neck Surgery, University of Alberta, Edmonton, Alta.(O'Connell); the Canadian Society of Colon and Rectal Surgeons and the Division of General Surgery, Department of Surgery, University of Ottawa, and the Ottawa Hospital Research Institute, Ottawa, Ont. (Moloo); the Canadian Association of Thoracic Surgeons and the Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ont. (Seely); the Canadian Orthopaedic Oncology Society and the Division of Orthopaedic Surgery, Department of Surgery, University of Ottawa, Ottawa, Ont. (Werier); the Canadian Society of Plastic Surgeons and the Department of Surgery, University of Toronto, Toronto, Ont. (Zhong); the Department of Surgery, McMaster University, Hamilton, Ont. (Finley); the Department of Gastrointestinal Oncology, Sunnybrook Health Sciences Centre, Toronto, Ont. (Earle); and the Canadian Journal of Surgery (Ball).

Summary: During the coronavirus disease 2019 (COVID-19) pandemic, delaying lifesaving cancer surgeries must be done with extreme caution and thoughtfulness. Modelling indicates that delays in high-risk cancer surgeries beyond 6 weeks could affect long-term outcomes for thousands of Canadians. Consequently, it is possible that postponing cancer surgery without consideration of its implications could cost more lives than can be saved by diverting all surgical resources to COVID-19. Read More

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http://dx.doi.org/10.1503/cjs.005620DOI Listing

Impact of socioeconomic status on psychological functioning in survivorship following breast cancer and reconstruction.

Breast J 2020 Apr 26. Epub 2020 Apr 26.

Section of Plastic and Reconstructive Surgery, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA.

Socioeconomic status (SES) remains an important population health risk factor and impacts a patient's experience of care during breast cancer. This study explored the relationship between SES and quality of life and satisfaction in survivorship following breast cancer and reconstruction. All patients underwent breast reconstruction at a single academic center from 2013 to 2017. Read More

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http://dx.doi.org/10.1111/tbj.13849DOI Listing

Current Status and Factors Influencing Surgical Options for Breast Cancer in China: A Nationwide Cross-Sectional Survey of 110 Hospitals.

Oncologist 2020 Apr 25. Epub 2020 Apr 25.

Department of Breast Surgery, Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.

Background: There are limited nationwide data regarding breast cancer surgery in China. The Chinese Anti-Cancer Association's Committee of Breast Cancer Society and the Chinese Society of Breast Surgeons conducted a nationwide survey to examine the use of and barriers associated with surgical options among patients with breast cancer.

Methods: Surveys were sent via e-mail to the directors of 110 centers that performed at least 200 breast cancer operations in 2017. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0001DOI Listing

Patient-Reported Outcomes after Irradiation of Tissue Expander versus Permanent Implant in Breast Reconstruction: A Multicenter Prospective Study.

Plast Reconstr Surg 2020 May;145(5):917e-926e

Ann Arbor, Mich.; and Boston, Mass. From the Section of Plastic and Reconstructive Surgery, the Center for Statistical Consultation and Research, and the Department of Radiation Oncology, University of Michigan; and Plastic Surgery, Brigham and Women's Hospital.

Background: Whether to irradiate the tissue expander before implant exchange or to defer irradiation until after exchange in immediate, two-stage expander/implant reconstruction remains uncertain. The authors evaluated the effects of irradiation timing on complication rates and patient-reported outcomes in patients undergoing immediate expander/implant reconstruction.

Methods: Immediate expander/implant reconstruction patients undergoing postmastectomy radiation therapy at 11 Mastectomy Reconstruction Outcomes Consortium sites with demographic, clinical, and complication data were analyzed. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184969PMC
May 2020
2.993 Impact Factor

Immediate unilateral breast reconstruction and contralateral breast augmentation with bilateral free deep inferior epigastric perforator flaps.

Ann R Coll Surg Engl 2020 Apr 24:e1-e3. Epub 2020 Apr 24.

Norfolk and Norwich University Hospitals, NHS Foundation Trust, Norwich, UK.

A 42-year-old woman was referred for consideration of left-sided mastectomy and immediate reconstruction. She previously had a bilateral breast augmentation using silicone implants. She desired to maintain her breast size and natural appearance. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0186DOI Listing

Long non‑coding RNA SNHG1 promotes breast cancer progression by regulation of LMO4.

Oncol Rep 2020 May 4;43(5):1503-1515. Epub 2020 Mar 4.

Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.

Long non‑coding RNA (lncRNA) small nucleolar RNA host gene 1 (SNHG1) was reported to be a critical regulator of tumorigenesis and is frequently deregulated in several cancer types. However, the exact mechanism by which SNHG1 contributes to breast cancer progression has not been fully elucidated. The identification of the molecular mechanism of SNHG1 is important for understanding the development of breast cancer and for improving the prognosis of the patients with this disease. Read More

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http://dx.doi.org/10.3892/or.2020.7530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107776PMC

Indocyanine green angiography for preventing postoperative mastectomy skin flap necrosis in immediate breast reconstruction.

Cochrane Database Syst Rev 2020 04 22;4:CD013280. Epub 2020 Apr 22.

Maastricht University Medical Center, Department of Plastic, Reconstructive and Hand Surgery, P. Debyelaan 25, Maastricht, Limburg, Netherlands, 6229 HX.

Background: Breast cancer will affect one in eight women during their lifetime. The opportunity to restore the removed tissue and cosmetic appearance is provided by reconstructive breast surgery following skin-sparing mastectomy (SSM). Mastectomy skin flap necrosis (MSFN) is a common complication following SSM breast reconstruction. Read More

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http://dx.doi.org/10.1002/14651858.CD013280.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175780PMC

Efficacy and safety of topical nitroglycerin in the prevention of mastectomy flap necrosis: a systematic review and meta-analysis.

Sci Rep 2020 Apr 21;10(1):6753. Epub 2020 Apr 21.

Department of Plastic and Reconstructive Surgery, Peking University Third Hospital, Haidian District, Beijing, 100191, P. R. China.

Flap necrosis is a common complication after mastectomy, and nitroglycerin (NTG) ointment has been used successfully to treat it. However, it is not clear whether topical NTG can completely prevent the occurrence of flap necrosis after breast cancer surgery, and it is also unclear whether this treatment may cause side effects. Three randomized controlled trials (RCTs) and two retrospective cohort studies (RCSs) were included in our investigation. Read More

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http://dx.doi.org/10.1038/s41598-020-63721-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174291PMC

Environmental factors associated with etiology of microbiologically confirmed reconstructive breast implant infections: impact on clinical management and treatment.

New Microbiol 2020 Apr 19;43(2). Epub 2020 Apr 19.

Infection Disease Clinic, Policlinico San Martino, Largo Rosanna Benzi 10, Genoa 16132, Italy.

Even if wide differences exist in the incidence of Gram-negative infections following breast cancer implant reconstructions (2-20%), its occurrence needs to be considered to optimize antibiotic therapy, which is usually directed towards Gram-positive cocci. There is a general notion on the possible source of Gram-negative microorganisms during outdoor activities. For this reason, we administered a specific questionnaire to infected patients to investigate this aspect. Read More

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Osteoradionecrosis of the Chest Wall.

Plast Reconstr Surg Glob Open 2020 Feb 25;8(2):e2665. Epub 2020 Feb 25.

Department of Pathology, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.

We present the case of a 48-year-old woman with a chronic ulcer with bony erosion over the right chest wall who had undergone adjuvant chemoradiotherapy for right breast cancer 18 years previously. Preoperative computed tomography revealed a large soft tissue ulcerative lesion with bony destruction of the anterolateral aspect of the right fifth and sixth ribs. Biopsy showed no evidence of recurrent malignancy. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159944PMC
February 2020

Challenges and Solutions for the Implementation of Shared Decision-making in Breast Reconstruction.

Plast Reconstr Surg Glob Open 2020 Feb 6;8(2):e2645. Epub 2020 Feb 6.

Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Mo.

Background: Patient-centered care is a hallmark of quality in healthcare. It is defined as care that is respectful of, and responsive to, individual patient preferences, needs, and values, while ensuring patients are informed and engaged in the treatment decision-making process.

Methods: We reviewed the literature and drew upon our own experiences to study the implementation of tools intended to facilitate shared decision-making in breast reconstruction. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159965PMC
February 2020