412,117 results match your criteria Breast Cancer


Ulcerated breast cancer with single brain metastasis: A combined surgical approach. Clinical presentation at one year follow up - A case report.

Int J Surg Case Rep 2020 Jun 20;73:75-78. Epub 2020 Jun 20.

Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Viale Oxford, 81, 00133, Rome, Italy. Electronic address:

Introduction: Breast cancer is the most common malignancy in woman. Approximately 5-10% of breast cancer occurs as de novo stage IV and some studies have shown that from 10% to 30% of those patients presents Brain Metastasis.

Presentation Of Case: In this study, we report a case of solitary brain metastasis of breast cancer in a 63-year-old Italian Caucasian woman with neurological symptoms as first clinical presentation. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.074DOI Listing

Skin carotenoids are inversely associated with adiposity in breast cancer survivors.

Nutr Res 2020 May 24;79:77-86. Epub 2020 May 24.

Yale School of Public Health, 60 College St, New Haven, CT 06511; Yale Cancer Center, PO Box 208028, New Haven, CT 06519. Electronic address:

Carotenoids are antioxidants which may mitigate some of the adverse effects of obesity, a condition associated with poor outcomes in breast cancer patients. We hypothesized that baseline skin carotenoids would be inversely associated with adiposity in breast cancer survivors and would increase with weight loss. Skin carotenoid score (SCS) was assessed by resonance Raman spectroscopy in breast cancer survivors (body mass index ≥25 kg/m) enrolled in a 6-month randomized controlled weight loss trial (n = 47). Read More

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http://dx.doi.org/10.1016/j.nutres.2020.05.012DOI Listing

Tenascin-C induces phenotypic changes in fibroblasts to myofibroblasts with high contractility through the integrin αvβ1/TGF-β/SMAD signaling axis in human breast cancer.

Am J Pathol 2020 Jul 7. Epub 2020 Jul 7.

Departments of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Tsu, Mie 514-8507, Japan; Research Center for Matrix Biology, Mie University, Tsu, Mie 514-8507, Japan. Electronic address:

Tenascin-C (TNC) is strongly expressed by fibroblasts and cancer cells in breast cancer. To assess the effects of TNC on stromal formation, we examined phenotypic changes in human mammary fibroblasts (HMFs) treated with TNC. The addition of TNC significantly up-regulated α-smooth muscle actin (SMA) and calponin. Read More

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http://dx.doi.org/10.1016/j.ajpath.2020.06.008DOI Listing

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma.

Cell 2020 Jul;182(1):200-225.e35

Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA. Electronic address:

To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive proteogenomic characterization of 110 tumors and 101 matched normal adjacent tissues (NATs) incorporating genomics, epigenomics, deep-scale proteomics, phosphoproteomics, and acetylproteomics. Multi-omics clustering revealed four subgroups defined by key driver mutations, country, and gender. Proteomic and phosphoproteomic data illuminated biology downstream of copy number aberrations, somatic mutations, and fusions and identified therapeutic vulnerabilities associated with driver events involving KRAS, EGFR, and ALK. Read More

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http://dx.doi.org/10.1016/j.cell.2020.06.013DOI Listing

Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer.

Pharmacogenet Genomics 2020 Jul 8. Epub 2020 Jul 8.

Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.

Objective: Based on our previous findings that postmenopausal women with estrone (E1) and estradiol (E2) concentrations at or above 1.3 pg/ml and 0.5 pg/ml, respectively, after 6 months of adjuvant anastrozole therapy had a three-fold risk of recurrence, we aimed to identify a single-nucleotide polymorphism (SNP)-based model that would predict elevated E1 and E2 and then validate it in an independent dataset. Read More

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http://dx.doi.org/10.1097/FPC.0000000000000415DOI Listing

Influence of preoperative breast cancer localization techniques on rates of sentinel lymph node visualization with preoperative lymphoscintigraphy.

Nucl Med Commun 2020 Jul 7. Epub 2020 Jul 7.

Department of Nuclear Medicine, Fiona Stanley Hospital.

Objectives: The use of preoperative image-guided lesion localization for impalpable breast cancer may interfere with lymphatic drainage and cause delayed or reduced visualization of sentinel lymph nodes (SLNs) on preoperative lymphoscintigraphy. The goal of this audit was to compare rates of SLN visualization in patients undergoing preoperative breast cancer localization with either Iodine 125 seeds (radio-guided occult lesion localization using Iodine 125 seeds, ROLLIS) or hook wire and those with palpable lesions where no localization was required.

Patients And Methods: We reviewed the records of 482 patients, who underwent preoperative lymphoscintigraphy with hook wire, ROLLIS, or no localization, at three major tertiary hospitals from January 2013 to December 2017. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001245DOI Listing

Evaluating the Image Quality of Monoenergetic Images From Dual-Energy Computed Tomography With Low-Concentration and Low-Flow-Rate Contrast Media for the Arterials Supply to the Nipple-Areola Complex in Breast Cancer Compared With Conventional Computed Tomography Angiography.

J Comput Assist Tomogr 2020 Jul 6. Epub 2020 Jul 6.

From the Department of Radiology, Chongqing University Cancer Hospital & Chongqing Cancer Hospital, & Chongqing Cancer Institute, Chongqing, P.R. China.

Objective: The objective of this study was to evaluate the image quality of monoenergetic images (MEIs (+)) acquired from dual-energy computed tomography with low-concentration and low-flow-rate contrast media for the arterial supply to the nipple-areola complex (NAC) in breast cancer compared with conventional computed tomography angiography (CTA).

Methods: We enrolled 25 patients (MEI (+)300 group, 300 mg/mL and 2.5 mL/s of contrast media) and 23 patients (CTA370 group, 370 mg/mL and 3. Read More

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http://dx.doi.org/10.1097/RCT.0000000000001063DOI Listing

PdpaMn inhibits fatty acid synthase-mediated glycolysis by down-regulating PI3K/Akt signaling pathway in breast cancer.

Anticancer Drugs 2020 Jul 8. Epub 2020 Jul 8.

School of Pharmacy.

Background: Novel manganese complex, PdpaMn ([(Pdpa)MnCl2]), was developed to induce apoptosis in breast cancer cells. The impact of phosphoinositide-(3)-kinase pathway onto fatty acid synthase (FASN) has an effect on cellular metabolism in breast cancer. However, reverse actions from FASN towards PI3K/Akt are still indefinable. Read More

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http://dx.doi.org/10.1097/CAD.0000000000000968DOI Listing

IL-22 promotes tumor growth of breast cancer cells in mice.

Aging (Albany NY) 2020 Jul 10;12. Epub 2020 Jul 10.

Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou 221002, China.

Increased interleukin-22 (IL-22) level was reported to associate with progression of breast cancer. Regulation of IL-22 in breast cancer still needs to be elucidated. We assessed the effect of giving IL-22 in tumor growth of mice inoculated with 4T1, MCF7 and MDA-MB-231 breast cancer cells. Read More

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http://dx.doi.org/10.18632/aging.103439DOI Listing

Subtype-specific risk models for accurately predicting the prognosis of breast cancer using differentially expressed autophagy-related genes.

Aging (Albany NY) 2020 Jul 10;12. Epub 2020 Jul 10.

Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, China.

Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (, , , and ), three- (, , and ), and five-gene (, , , , and ) risk models were identified, which all have a receiver operating characteristic > 0. Read More

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http://dx.doi.org/10.18632/aging.103437DOI Listing

Patient reported cosmetic outcome after vacuum assisted excision of benign breast lesions: a cross-sectional study.

Br J Radiol 2020 Jul 10:20190994. Epub 2020 Jul 10.

Department of Radiology, Franciscus Gasthuis & Vlietland, Rotterdam, the Netherlands.

Objective: Better cosmetic outcome after vacuum assisted excision (VAE) compared to surgical excision of benign breast lesions is suggested in previous studies but has never been evaluated with validated outcome measures. In this study patient reported cosmetic outcome after VAEwas evaluated.

Methods: Patients who underwent VAE between July 2017 and December 2018 were invited to complete the cosmetic subscale of the Dutch Breast Cancer Treatment Outcome Scale, comparing the treated with the untreated breast. Read More

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http://dx.doi.org/10.1259/bjr.20190994DOI Listing

Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from .

J Nat Prod 2020 Jul 10. Epub 2020 Jul 10.

Natural Products Discovery Group, Institute for Natural Products Applications and Research Technologies, Stephenson Life Science Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.

Triple-negative breast cancers (TNBC) are aggressive and heterogeneous cancers that lack targeted therapies. We implemented a screening program to identify new leads for subgroups of TNBC using diverse cell lines with different molecular drivers. Through this program, we identified an extract from that caused selective cytotoxicity in BT-549 cells as compared to four other TNBC cell lines. Read More

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http://dx.doi.org/10.1021/acs.jnatprod.0c00423DOI Listing

Should uncertainty concerning the risk of malignancy be included in diagnostic (nongynecologic) cytopathology reports?

Cancer Cytopathol 2020 Jul 10. Epub 2020 Jul 10.

Institute of Molecular Pathology and Immunology of University of Porto, Porto, Portugal.

In diagnostic cytology, the known site-specific false positive rates at various anatomical sites for the risk malignancy (ROM) when a confirmed malignant diagnosis is made are comparatively well documented. ROM figures for diagnostic cytology specimens may vary according to the anatomical site of the specimen, the exact nature of the specimen received, the staining method(s) used, and the use of additional laboratory techniques including molecular profiling; furthermore, they often differ to some extent from institution to institution, between differing cytologists within the same institution, and over time. A brief literature review for a selected group of routine diagnostic cytology specimens shows a published ROM for a confirmed malignant diagnosis as follows: bile duct brushings, ~99% (range, 97%-100%); breast fine needle aspiration, 98. Read More

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http://dx.doi.org/10.1002/cncy.22322DOI Listing

Development and validation of a novel 15-CpG-based signature for predicting prognosis in triple-negative breast cancer.

J Cell Mol Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

DNA methylation is an important biological regulatory mechanism that changes gene expression without altering the DNA sequence. Increasing studies have revealed that DNA methylation data play a vital role in the field of oncology. However, the methylation site signature in triple-negative breast cancer (TNBC) remains unknown. Read More

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http://dx.doi.org/10.1111/jcmm.15588DOI Listing

Productivity costs associated with metastatic breast cancer in younger, midlife, and older women.

Cancer 2020 Jul 10. Epub 2020 Jul 10.

Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Background: The objective of the current study was to estimate productivity costs due to metastatic breast cancer (mBC) via productive time lost among survivors and potential life-years lost from premature mortality among 3 age groups: younger (aged 18-44 years), midlife (aged 45-64 years), and older (aged ≥65 years) women.

Methods: The authors estimated the number of work and home productivity days missed due to mBC by age group using data from the 2000 to 2016 National Health Interview Survey. Years of potential life lost (YPLL) due to mBC were calculated for each age group using 2015 National Vital Statistics System data. Read More

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http://dx.doi.org/10.1002/cncr.33077DOI Listing

In Vitro Vascularized Tumor Platform for Modeling Tumor-Vasculature Interactions of Inflammatory Breast Cancer.

Biotechnol Bioeng 2020 Jul 10. Epub 2020 Jul 10.

Department of Biomedical Engineering, The University of Texas at Austin, TX, USA.

Inflammatory breast cancer (IBC), a rare form of breast cancer associated with increased angiogenesis and metastasis, is largely driven by tumor-stromal interactions with the vasculature and the extracellular matrix (ECM). However, there is currently a lack of understanding of the role these interactions play in initiation and progression of the disease. In this study, we developed the first three-dimensional, in vitro, vascularized, microfluidic IBC platform to quantify the spatial and temporal dynamics of tumor-vasculature and tumor-ECM interactions specific to IBC. Read More

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http://dx.doi.org/10.1002/bit.27487DOI Listing

Isothymusin, a potential inhibitor of cancer cell proliferation: An in silico and in vitro investigation.

Curr Top Med Chem 2020 Jul 9. Epub 2020 Jul 9.

Molecular Bioprospection Department of Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow-226015, Uttar Pradesh. India.

Background: Since centuries plant-based compounds are known for the treatment of cancer in both traditional and contemporary medicine. The problems like target non-specificity and toxicity are well-known regarding anticancer drugs. Therefore, target specific search of novel entities is constant. Read More

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http://dx.doi.org/10.2174/1568026620666200710103636DOI Listing

Ratite oils for local transdermal therapy of 4-OH Tamoxifen: Development, Characterization and Evaluation.

J Liposome Res 2020 Jul 10:1-38. Epub 2020 Jul 10.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Selangor Darul Ehsan, Malaysia.

The anti-inflammatory property of ratite oils as well as its ability to act as a penetration enhancer makes it an ideal agent to be used in transdermal formulations. The present study aims to develop an effective transfersomal delivery of 4-hydroxytamoxifen, an anti-cancer drug, using ratite oil as a carrier agent for the treatment of breast cancer. The 4-hydroxytamoxifen transfersomes were prepared with and without ratite oils using soy phosphatidylcholine and three different edge activators in five different molar ratios using the rotary evaporation-ultrasonication method. Read More

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http://dx.doi.org/10.1080/08982104.2020.1777155DOI Listing

Postmenopausal hormone therapy in BRCA gene mutation carriers: to whom and which?

Expert Opin Drug Saf 2020 Jul 10:1-6. Epub 2020 Jul 10.

Department of Medical and Surgical Sciences for Mother, Child and Adult, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico , Modena, Italy.

Introduction: Risk-reducing-salpingo-oophorectomy (RRSO) inevitably leads BRCA mutation carriers to premature menopause.

Areas Covered: To evaluate the existing evidence for use of postmenopausal hormone therapy (HT) in BRCAmc, after RRSO or menopause occurring naturally, for both breast cancer (BC) survivors and those without BC.

Expert Opinion: All BC survivors are excluded from any HT treatment: in other BRCAmc, before 51 years of age the benefits of HT overcome the risks after RRSO and/or premature ovarian insufficiency (POF). Read More

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http://dx.doi.org/10.1080/14740338.2020.1791818DOI Listing

Stretch Induces Invasive Phenotypes in Breast Cells Due to Activation of Aerobic-Glycolysis-Related Pathways.

Adv Biosyst 2019 Jul 7;3(7):e1800294. Epub 2019 May 7.

Nano Bio Electronic Devices Lab, School of Electrical and Computer Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran.

It is increasingly being accepted that cells' physiological functions are substantially dependent on the mechanical characteristics of their surrounding tissue. This is mainly due to the key role of biomechanical forces on cells and their nucleus' shapes, which have the capacity to regulate chromatin conformation and thus gene regulations. Therefore, it is reasonable to postulate that altering the biomechanical properties of tissue may have the capacity to change cell functions. Read More

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http://dx.doi.org/10.1002/adbi.201800294DOI Listing

3D Microenvironment Stiffness Regulates Tumor Spheroid Growth and Mechanics via p21 and ROCK.

Adv Biosyst 2019 Sep 24;3(9):e1900128. Epub 2019 Jul 24.

TU Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Fetscherstr. 105, 01307, Dresden, Germany.

The mechanical properties of cancer cells and their microenvironment contribute to breast cancer progression. While mechanosensing has been extensively studied using 2D substrates, much less is known about it in a physiologically more relevant 3D context. Here it is demonstrated that breast cancer tumor spheroids, growing in 3D polyethylene glycol-heparin hydrogels, are sensitive to their environment stiffness. Read More

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http://dx.doi.org/10.1002/adbi.201900128DOI Listing
September 2019

Psychosocial needs and responses for breast cancer patients during Covid-19 pandemic in a hospital of southern europe.

Psychooncology 2020 Jul 10. Epub 2020 Jul 10.

Medical Oncology Department, Complejo Hospitalario de Navarra. Pamplona, Spain.

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http://dx.doi.org/10.1002/pon.5465DOI Listing

Factors influencing breast cancer awareness: a cross-sectional study in China.

J Comp Eff Res 2020 Jul 10. Epub 2020 Jul 10.

Nursing School, Jilin University, Changchun, Jilin Province, China.

This study aimed to explore the factors that influence breast cancer awareness. A community-based cross-sectional study was conducted between January and April 2019 in Changchun, Jilin Province, China. A total of 274 women were recruited for this cross-sectional study. Read More

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http://dx.doi.org/10.2217/cer-2020-0037DOI Listing

Long-term patient-rated cosmetic and satisfactory outcomes of early breast cancer treated with conventional versus hypofractionated breast irradiation with simultaneous integrated boost technique.

Breast J 2020 Jul 9. Epub 2020 Jul 9.

Division of Radiation Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

To compare patient-rated cosmetic and satisfactory outcomes between conventional fractionation with simultaneously integrated boost (C-SIB) vs hypofractionation with SIB (H-SIB) in early breast cancer. Patients with stage I and II breast cancer who received breast-conserving surgery followed by radiation with SIB to tumor bed and completed questionnaire were included in this study. Radiotherapy was as follows: C-SIB arm = 50 Gy and 65 Gy in 25 fractions and H-SIB arm = 43. Read More

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http://dx.doi.org/10.1111/tbj.13960DOI Listing

Effectiveness of Using Personal Health Records to Improve Recommended Breast Cancer Screening and Reduce Racial and Geographic Disparities Among Women.

J Cancer Educ 2020 Jul 9. Epub 2020 Jul 9.

Department of Economics, the Fogelman College of Business and Economics, The University of Memphis, Memphis, TN, 38152, USA.

This paper examines the effectiveness of using personal health records (PHRs), which contains detailed health information to improve the use of recommended screening mammography among women at potential risk for breast cancer. It also explores the potential of PHR in reducing disparities in recommended mammography use experienced by minority and underserved women. The primary data used for this study were obtained from the 2015 Health Information National Trends Survey, and they were supplemented by the 2016 Area Health Resource Files. Read More

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http://dx.doi.org/10.1007/s13187-020-01821-2DOI Listing

Prognostic Value and Risk Factors of Peritoneal Carcinomatosis Recurrence for Patients with Endometrial Cancer: A Multicenter Study from the FRANCOGYN Group.

Ann Surg Oncol 2020 Jul 9. Epub 2020 Jul 9.

AP-HP (Assistance Publique des Hôpitaux de Paris), Department of Gynecological and Breast Surgery and Oncology, Pitié-Salpêtrière University Hospital, Paris, France.

Background: The prognosis for patients with endometrial cancer (EC) peritoneal carcinomatosis (PC) recurrence has received little study. This study aimed to determine specific risk factors and prognosis of EC with PC recurrence (PCR) versus no PC recurrence (NPCR).

Methods: Data of all patients with EC who received primary surgical treatment between January 2000 and February 2017 were abstracted from the French FRANCOGYN Research Group database. Read More

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http://dx.doi.org/10.1245/s10434-020-08812-zDOI Listing

ASO Author Reflections: Breast-Conserving Surgery Could be Performed Safely in Well-Selected T1-T2 Centrally Located Breast Cancer.

Ann Surg Oncol 2020 Jul 9. Epub 2020 Jul 9.

Department of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

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http://dx.doi.org/10.1245/s10434-020-08839-2DOI Listing

Variation in pathological complete response in HER2-positive breast cancers with intrinsic subtypes assessed by PAM50 testing: secondary analysis from NSABP B-41 trial.

Breast Cancer Res Treat 2020 Jul 9. Epub 2020 Jul 9.

Department of Radiation Oncology, Max Superspecialty Hospital, Vaishali, Ghaziabad, India.

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http://dx.doi.org/10.1007/s10549-020-05790-4DOI Listing

Evaluation of a beneficial effect of adjuvant chemotherapy in patients with stage I triple-negative breast cancer: a population-based study using the SEER 18 database.

Breast Cancer Res Treat 2020 Jul 9. Epub 2020 Jul 9.

Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

Purpose: To evaluate the effect of adjuvant chemotherapy on improving the prognosis of patients with stage I triple-negative breast cancer (TNBC).

Methods: TNBC patients diagnosed in the SEER 18 database from 2010 to 2015 were included. Kaplan-Meier plots and log-rank tests were used to compare the differences in breast cancer-specific survival (BCSS) and overall survival (OS) between subgroups of variables. Read More

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http://dx.doi.org/10.1007/s10549-020-05776-2DOI Listing

Venous thromboembolism risk in patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with combined CDK 4/6 inhibitors plus endocrine therapy versus endocrine therapy alone: a systematic review and meta-analysis of randomized controlled trials.

Breast Cancer Res Treat 2020 Jul 9. Epub 2020 Jul 9.

Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd (Unit 1464), Houston, TX, 77030, USA.

Purpose: Approximately 70% of patients with metastatic breast cancer (MBC) are hormone receptor (HR)-positive. Recent studies have shown that CDK4/6 inhibitors (CDKI) improve survival in combination with ET in HR-positive, HER2-negative MBC. The risk of venous thromboembolism (VTE) is 3-4 times higher in patients with breast cancer (BC) than in patients without cancer. Read More

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http://dx.doi.org/10.1007/s10549-020-05783-3DOI Listing

Assessing preferences for receiving supportive care resources among patients seen at a Breast Care Center.

Breast Cancer Res Treat 2020 Jul 9. Epub 2020 Jul 9.

University of California San Francisco, San Francisco, California, USA.

Background: Patients with breast cancer or at high risk for breast cancer have supportive care needs. Although cancer centers offer social, psychological, and other support to these patients, these services are not always utilized, and patients continue to report unmet supportive care needs. Reasons for non-utilization of these services have not been well documented. Read More

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http://dx.doi.org/10.1007/s10549-020-05786-0DOI Listing

External validation and modification of nomogram for predicting positive resection margins before breast conserving surgery.

Breast Cancer Res Treat 2020 Jul 9. Epub 2020 Jul 9.

Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: A positive resection margin after breast conserving surgery (BCS) is the most important risk factor for tumor recurrence. In 2012, Seoul National University Hospital (SNUH) breast surgery team developed a nomogram for predicting positive resection margins before BCS to provide individual surgical plans that could reduce local recurrence without increasing re-excision rates. The purpose of this study was to validate this nomogram using an external cohort and to test if addition of surgeon-related factor could improve its use as a predictive model. Read More

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http://dx.doi.org/10.1007/s10549-020-05779-zDOI Listing

Economic Evaluation of Cisplatin Plus Gemcitabine Versus Paclitaxel Plus Gemcitabine for the Treatment of First-Line Advanced Metastatic Triple-Negative Breast Cancer in China: Using Markov Model and Partitioned Survival Model.

Adv Ther 2020 Jul 9. Epub 2020 Jul 9.

School of International Pharmaceutical Business, China Pharmaceutical University, Nanjing, Jiangsu, People's Republic of China.

Introduction: This study aimed to evaluate the cost-effectiveness of cisplatin plus gemcitabine vs. paclitaxel plus gemcitabine as a first-line treatment for metastatic triple-negative breast cancer in China.

Methods: The Markov model and partitioned survival (PS) model were used, and the study included three health states over the period of a lifetime. Read More

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http://dx.doi.org/10.1007/s12325-020-01418-7DOI Listing

Sarcopenia and monocyte-to-lymphocyte ratio as prognostic factors in early-stage breast cancer.

Ann Transl Med 2020 Jun;8(12):737

Medical Oncology Department, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

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http://dx.doi.org/10.21037/atm.2020.03.171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333145PMC

Incidence and Predictors of Recurrence among Breast Cancer Patients in Black Lion Specialized Hospital Adult Oncology Unit, Addis Ababa, Ethiopia: Retrospective Follow-up Study with Survival Analysis.

J Cancer Prev 2020 Jun;25(2):111-118

College of Health Science, Addis Ababa University, Addis Ababa, Ethiopia.

Currently, breast cancer is becoming a major public health problem for developing countries. In Ethiopia, breast cancer is the most prevalent cancer among women, and constitutes a major public health concern. Hence, this study was aimed to determine the incidence and predictor of recurrence among breast cancer clients at Black Lion Specialized Hospital, Ethiopia, in 2018. Read More

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http://dx.doi.org/10.15430/JCP.2020.25.2.111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337003PMC

15-Deoxy-Δ-prostaglandin J Induces Apoptosis in Ha--transformed Human Breast Epithelial Cells by Targeting IκB kinase-NF-κB Signaling.

J Cancer Prev 2020 Jun;25(2):100-110

Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, Korea.

15-Deoxy-Δ-prostaglandin J (15d-PGJ), an endogenous ligand for PPARγ, has differential effects on cancer cell proliferation and survival depending on the dose and the type of cells. In the present study, we have investigated the effects of 15d-PGJ on apoptosis of the Ha- transformed human breast epithelial (MCF10A-) cells. When MCF10A- cells were treated with 15d-PGJ (10 μM) for 24 hours, they underwent apoptosis as evidenced by characteristic morphological features, an increased proportion of sub-G/G cell population, a typical pattern of annexin V/propidium iodide staining, perturbation of mitochondrial transmembrane potential (Δψ), and cleavage of caspase-3 and its substrate PARP. Read More

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http://dx.doi.org/10.15430/JCP.2020.25.2.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337001PMC

Chemopreventive and Chemotherapeutic Effect of Propolis and Its Constituents: A Mini-review.

J Cancer Prev 2020 Jun;25(2):70-78

School of Nutrition, Chung Shan Medical University, Taiwan, ROC.

Propolis is a bee wax rich in various phytocomponents and traditionally used to treat various ailments. Propolis is reported to possess an array of biological properties including anti-inflammatory, antioxidant, anti-cancer, and anti-diabetic as well as cardioprotective, hepatoprotective, renoprotective, and derma protective activities. A plethora of studies confirmed that propolis is effective against various types of cancer including head and neck, lung, liver, brain (glioma), pancreas, kidney, prostate, skin (melanoma), breast, oral, esophagus, gastric, colorectal, and bladder cancers. Read More

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http://dx.doi.org/10.15430/JCP.2020.25.2.70DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337007PMC

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells.

Cancer Metab 2020 6;8:13. Epub 2020 Jul 6.

Department of Oncology, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DS UK.

Background: Humans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitochondrial inner membrane and converts that energy into heat. It is unclear whether cancer cells can exhibit autonomous thermogenesis. Read More

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http://dx.doi.org/10.1186/s40170-020-00219-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336487PMC

Current State of the Art in the Adjuvant Systemic Treatment of Premenopausal Patients With Early Breast Cancer.

Clin Med Insights Oncol 2020 29;14:1179554920931816. Epub 2020 Jun 29.

Department of Medical Oncology, U.O.C Clinica di Oncologia Medica, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Breast cancer is the most frequent malignancy diagnosed in premenopausal women. In this age group, breast tumors tend to be diagnosed at more advanced stages and to harbor more aggressive biological features. In addition, specific age-related issues including genetic counseling, fertility preservation, impact on social and couple relationships, working life, and management of long-term side effects should be considered highly relevant when managing early breast cancer in premenopausal women. Read More

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http://dx.doi.org/10.1177/1179554920931816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325453PMC

The Upregulation of hsa-mir-181b-1 and Downregulation of Its Target CYLD in the Late-Stage of Tumor Progression of Breast Cancer.

Indian J Clin Biochem 2020 Jul 21;35(3):312-321. Epub 2019 Mar 21.

Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, 81746-73461 Iran.

Some microRNAs are usually dysregulated in the cancers and influencing tumor behavior and progression. Hsa-miR-181b-1 and its target are involved in regulating the inflammatory pathways. This study aimed to investigate the expression levels of hsa-mir-181b-1 and in a cohort of breast tumor tissues and normal adjacent tissues to assess their association with breast cancer stages. Read More

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http://dx.doi.org/10.1007/s12291-019-00826-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326880PMC

Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38-MK2 axis and affects NF-κB-mediated transcription.

Sci Rep 2020 Jul 9;10(1):11388. Epub 2020 Jul 9.

Department of Pharmacy, UiT The Arctic University of Norway, 9037, Tromsø, Norway.

Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Read More

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http://dx.doi.org/10.1038/s41598-020-68219-4DOI Listing

Development and validation of a nomogram prognostic model for esophageal cancer patients with oligometastases.

Sci Rep 2020 Jul 9;10(1):11259. Epub 2020 Jul 9.

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Science, Jiyan Road 440, Jinan, 250117, Shandong Province, China.

Platinum-based chemotherapy is recommended as the standard treatment for metastatic esophageal cancer (EC) patients; however, the outcome is poor. Oligometastasis is less aggressive and has limited growth potential. However, the prognostic factors for EC patients with oligometastases was largely unknown. Read More

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http://dx.doi.org/10.1038/s41598-020-68160-6DOI Listing

Comprehensive characterization of claudin-low breast tumors reflects the impact of the cell-of-origin on cancer evolution.

Nat Commun 2020 Jul 9;11(1):3431. Epub 2020 Jul 9.

Cancer Research Center of Lyon, Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Equipe Labellisée Ligue contre le Cancer, 69008, Lyon, France.

Claudin-low breast cancers are aggressive tumors defined by the low expression of key components of cellular junctions, associated with mesenchymal and stemness features. Although they are generally considered as the most primitive breast malignancies, their histogenesis remains elusive. Here we show that this molecular subtype of breast cancers exhibits a significant diversity, comprising three main subgroups that emerge from unique evolutionary processes. Read More

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http://dx.doi.org/10.1038/s41467-020-17249-7DOI Listing

Twist-mediated PAR1 induction is required for breast cancer progression and metastasis by inhibiting Hippo pathway.

Cell Death Dis 2020 Jul 9;11(7):520. Epub 2020 Jul 9.

Department of Pathology and Pathophysiology, and Department of Surgical Oncology (breast center) of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Breast cancer is considered to be the most prevalent cancer in women worldwide, and metastasis is the primary cause of death. Protease-activated receptor 1 (PAR1) is a GPCR family member involved in the invasive and metastatic processes of cancer cells. However, the functions and underlying mechanisms of PAR1 in breast cancer remain unclear. Read More

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http://dx.doi.org/10.1038/s41419-020-2725-4DOI Listing

Transcriptional repression of PTEN in neural cells using CRISPR/dCas9 epigenetic editing.

Sci Rep 2020 Jul 9;10(1):11393. Epub 2020 Jul 9.

School of Human Sciences, Faculty of Science, The University of Western Australia, 35 Stirling Highway, Perth, WA, 6009, Australia.

After damage to the adult mammalian central nervous system (CNS), surviving neurons have limited capacity to regenerate and restore functional connectivity. Conditional genetic deletion of PTEN results in robust CNS axon regrowth, while PTEN repression with short hairpin RNA (shRNA) improves regeneration but to a lesser extent, likely due to suboptimal PTEN mRNA knockdown using this approach. Here we employed the CRISPR/dCas9 system to repress PTEN transcription in neural cells. Read More

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http://dx.doi.org/10.1038/s41598-020-68257-yDOI Listing

How to know what to know: Information challenges for women in the diagnostic phase of breast cancer.

Patient Educ Couns 2020 Jun 30. Epub 2020 Jun 30.

St. Mary's Research Centre, St. Mary's Hospital, 3880 Avenue Lacombe, Hayes Pavillon, Suite 4720, Montreal, QC, H3T 1M5, Canada; Department of Family Medicine, McGill University, 5858 Côte-des-Neiges Rd, Montreal, QC, H3S 1Z1, Canada. Electronic address:

Objective: To explore how women describe efforts to seek, appraise and interpret information during the diagnostic phase of her breast cancer care.

Methods: Qualitative interviews with 35 women with breast cancer across Canada, using audio/video recording. Thematic analysis was used to identify topics important to participants (original results published: www. Read More

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http://dx.doi.org/10.1016/j.pec.2020.06.030DOI Listing

HOPE for Rational Statin Allocation for Primary Prevention: A Coronary Artery Calcium Picture Is Worth 1000 Words.

Mayo Clin Proc 2020 Jul 2. Epub 2020 Jul 2.

Department of Applied Health Science, School of Public Health, Indiana University Bloomington, IN.

Allocation of statin therapy for the primary prevention of atherosclerotic cardiovascular disease (ASCVD) in borderline- and intermediate-risk patients has traditionally been based on population-based global risk assessment and other clinical and laboratory characteristics. Patient-specific treatment decisions are needed to provide maximal benefit and avoid unnecessary treatment. Guideline-based lipid management proposes that coronary artery calcium scoring is reasonable to implement in patients with a 10-year risk of 5. Read More

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http://dx.doi.org/10.1016/j.mayocp.2020.01.016DOI Listing

Comparison of conventional and advanced radiotherapy techniques for left-sided breast cancer after breast conserving surgery.

Med Dosim 2020 Jul 6. Epub 2020 Jul 6.

Department of Physics and Astronomy, Louisiana State University, Baton Rouge, LA, USA; Department of Radiation Oncology, Mary Bird Perkins Cancer Center, Baton Rouge, LA, USA. Electronic address:

Whole breast radiotherapy (WBRT) after breast conserving surgery is the standard treatment to prevent recurrence and metastasis of early stage breast cancer. This study aims to compare seven WBRT techniques including conventional tangential, field-in-field (FIF), hybrid intensity-modulated radiotherapy (IMRT), IMRT, standard volumetric modulated arc therapy (STD-VMAT), noncoplanar VMAT (NC-VMAT), and multiple arc VMAT (MA-VMAT). Fifteen patients who were previously diagnosed with left-sided early stage breast cancer and treated in our clinic were selected for this study. Read More

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http://dx.doi.org/10.1016/j.meddos.2020.05.004DOI Listing

Quantitative Effect of Bolus on Skin Dose in Postmastectomy Radiation Therapy.

J Med Imaging Radiat Sci 2020 Jul 6. Epub 2020 Jul 6.

Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.

Background: In postmastectomy radiation therapy (PMRT), some centres prescribe the use of a tissue-equivalent bolus to the skin to reduce the risk of chest wall recurrence. The addition of bolus causes an increase in the skin dose, which may lead to increased risk of radiodermatitis. Radiodermatitis can decrease patients' overall quality of life, bringing into question the benefit of using the bolus. Read More

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http://dx.doi.org/10.1016/j.jmir.2020.06.006DOI Listing

21-gene recurrence score testing utilization among older women from different races: A population-based study.

J Geriatr Oncol 2020 Jul 7. Epub 2020 Jul 7.

Utah Cancer Registry, 250 East 200 South, Room 1375, Salt Lake City, UT 84111, United States of America; Department of Internal Medicine, Division of Epidemiology, University of Utah Health, 295 Chipeta Building, Salt Lake City, UT 84108, United States of America. Electronic address:

Objectives: The influence of older age at diagnosis in combination with race/ethnicity on utilization and results of the 21-gene recurrence score (RS) assay for breast cancer (BC) patients is not fully understood. Our objectives were to evaluate the utilization of RS among older women with BC, the likelihood of a high-risk RS, and factors associated with breast cancer-specific mortality (BCSM) among older patients across different races.

Materials And Methods: We utilized the Surveillance, Epidemiology, and Results (SEER) database with linked RS results to evaluate women with estrogen receptor-positive BC diagnosed 2004-2015. Read More

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http://dx.doi.org/10.1016/j.jgo.2020.06.004DOI Listing