439,030 results match your criteria Breast Cancer

Oestrogen receptor activity in hormone-dependent breast cancer during chemotherapy: ER activity in pre-menopausal HR+ breast cancer during CT.

EBioMedicine 2021 Jun 20;69:103451. Epub 2021 Jun 20.

Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Medical Oncology, Hospital Clinic of Barcelona, Spain; SOLTI cooperative group, Barcelona, Spain; Institute of Oncology (IOB)-Hospital Quirónsalud, Barcelona, Spain; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA; Department of Medicine, University of Barcelona, Barcelona, Spain. Electronic address:

Background: Chemotherapy efficacy in early-stage hormone receptor-positive (HR+) breast cancer (BC) according to menopausal status needs a biological explanation.

Methods: We compared early-stage HR+ BC biological features before and after (neo)adjuvant chemotherapy or endocrine therapy (ET), and assessed oestrogen receptor (ER) pathway activity in both pre- and post-menopausal patients. The nCounter platform was used to detect gene expression levels. Read More

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New pyrimidine and pyrazole-based compounds as potential EGFR inhibitors: Synthesis, anticancer, antimicrobial evaluation and computational studies.

Bioorg Chem 2021 Jun 10;114:105078. Epub 2021 Jun 10.

Pharmaceutical Medicinal Chemistry and Drug Design Department, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11754, Egypt.

This study was focused on the synthesis of new pyrimidines 4a,b, 5a,b and pyrazoles 6a, b as ATP mimicking tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). The new compounds were assessed as cytotoxic candidates against human breast cancer cells (MCF-7) and hepatocellular carcinoma cells (HepG-2). All the new compounds appeared as more potent cytotoxic agents than erlotinib, while only compound 4a exhibited more potency than 5-flourouracil and 4b analogue was equipotent to it. Read More

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Racial/ethnic differences in health-related quality of life among female breast cancer survivors: cross-sectional findings from the Medical Expenditure Panel Survey.

Public Health 2021 Jun 20;196:74-81. Epub 2021 Jun 20.

University of Texas School of Public Health, Center for Health Promotion and Prevention Research, Division of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objectives: Breast cancer survivors have reported worse health-related quality of life (HRQoL) outcomes on some subscales when compared with members of the general population. However, the increased attention to breast cancer survivorship should have improved the HRQoL of these survivors. Our aim was to examine whether physical and mental component scores (PCS-12 and MCS-12) using the Short Form (SF-12) questionnaire were different for racial/ethnic minorities, specifically for Black and Hispanic women relative to White women. Read More

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Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter.

Cell Rep 2021 Jun;35(12):109275

Department of Biomedical Sciences, University of Padua, 35131 Padua, Italy; Myology Center (CIR-Myo), University of Padua, 35131 Padua, Italy. Electronic address:

The mitochondrial calcium uniporter (MCU), the highly selective channel responsible for mitochondrial Ca entry, plays important roles in physiology and pathology. However, only few pharmacological compounds directly and selectively modulate its activity. Here, we perform high-throughput screening on a US Food and Drug Administration (FDA)-approved drug library comprising 1,600 compounds to identify molecules modulating mitochondrial Ca uptake. Read More

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Riok3 inhibits the antiviral immune response by facilitating TRIM40-mediated RIG-I and MDA5 degradation.

Cell Rep 2021 Jun;35(12):109272

Cancer Institute, ZJU-UCLA Joint Center for Medical Education and Research, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:

The type I interferon (IFN) pathway is a key component of innate immune response upon invasion of foreign pathogens. It is also under precise control to prevent excessive upregulation and undesired inflammation cascade. In the present study, we report that Riok3, an atypical kinase, negatively regulates retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) sensing-induced type I IFN signaling. Read More

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Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer.

Cell Rep 2021 Jun;35(12):109285

Department of Medicine, Division of Hematology and Oncology, Department of Medicine, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee Health Science Center, Memphis, TN 38163, USA; Department of Microbiology, Immunology, and Biochemistry, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA; UTHSC Center for Cancer Research, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address:

Immune checkpoint blockade (ICB) has improved outcomes in some cancers. A major limitation of ICB is that most patients fail to respond, which is partly attributable to immunosuppression. Obesity appears to improve immune checkpoint therapies in some cancers, but impacts on breast cancer (BC) remain unknown. Read More

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Sedentary work and breast cancer risk: A systematic review and meta-analysis.

J Occup Health 2021 Jan;63(1):e12239

Department of Occupational and Environmental Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: This systematic review and meta-analysis aimed to assess sedentary work's contribution to breast cancer risk quantitatively using thorough research articles.

Methods: We performed a meta-analysis using a registered protocol in PROSPERO (registration number: CRD42020204629). Literature from PubMed, Embase, and Cochrane involving sedentary work and breast cancer risk was reviewed. Read More

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January 2021

The impact of fertility preservation on the timing of breast cancer treatment, recurrence, and survival.

Cancer 2021 Jun 23. Epub 2021 Jun 23.

Center for Infertility and Reproductive Surgery, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts.

Background: Many young women with breast cancer undergo fertility preservation (FP) before cancer treatment. This study examined the impact of FP on breast cancer outcomes.

Methods: The authors performed a retrospective cohort study of 272 women aged 20 to 45 years with newly diagnosed stage 0 to III breast cancer who underwent an FP consultation between 2005 and 2017. Read More

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A randomized trial of exercise and diet on health-related quality of life in survivors of breast cancer with overweight or obesity.

Cancer 2021 Jun 23. Epub 2021 Jun 23.

Department of Public Health Sciences, Penn State College of Medicine, Hershey, Pennsylvania.

Background: Obesity is a chronic, relapsing, and progressive disease; it is associated with poor health-related quality of life (HRQOL) in survivors of breast cancer.

Methods: In this 2 × 2 factorial trial, 351 survivors of breast cancer with overweight or obesity were randomized to 1 of 4 treatment groups for 52 weeks: control, exercise alone, diet alone, or exercise plus diet. HRQOL end points were measured at baseline and at week 52 using the 36-Item Medical Outcomes Survey-Short Form (SF-36). Read More

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Loneliness and mental health during the COVID-19 pandemic in older breast cancer survivors and noncancer controls.

Cancer 2021 Jun 23. Epub 2021 Jun 23.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia.

Background: The coronavirus disease 2019 (COVID-19) pandemic has had wide-ranging health effects and increased isolation. Older with cancer patients might be especially vulnerable to loneliness and poor mental health during the pandemic.

Methods: The authors included active participants enrolled in the longitudinal Thinking and Living With Cancer study of nonmetastatic breast cancer survivors aged 60 to 89 years (n = 262) and matched controls (n = 165) from 5 US regions. Read More

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Revealing nuclear receptor hub modules from Basal-like breast cancer expression networks.

PLoS One 2021 23;16(6):e0252901. Epub 2021 Jun 23.

School of Food Science & Nutrition, Faculty of Environment, University of Leeds, Leeds, United Kingdom.

Nuclear receptors are a class of transcriptional factors. Together with their co-regulators, they regulate development, homeostasis, and metabolism in a ligand-dependent manner. Their ability to respond to environmental stimuli rapidly makes them versatile cellular components. Read More

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Thymic Immunosuppressive Pentapeptide (TIPP) Showed Anticancer Activity in Breast Cancer and Chronic Myeloid Leukemia Both In Vitro and In Vivo.

Protein Pept Lett 2021 Jun 22. Epub 2021 Jun 22.

Key Laboratory of Chemical Biology (Ministry of Education), Institute of Biochemical and Biotechnological Drug, School of Pharmaceutical Sciences, Shandong University, No.44 Wenhuaxi Road, Jinan 250012, China.

Aim: Being the common cause and major burden of deaths globally, timely management of cancer is crucial.

Background: Thymic immunosuppressive pentapeptide (TIPP) is a novel pentapeptide originally obtained from calf thymic immunosuppressive extract. Previously, TIPP has been proved to suppress the allergic and inflammatory responses in allergic mice via blocking MAP kinases/NF-κB signaling pathways. Read More

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Qualitative exploration of the reproductive health perceptions of middle-aged women in the United States.

J Women Aging 2021 Jun 23:1-10. Epub 2021 Jun 23.

College of Health and Human Services, School of Interdisciplinary Health Programs, Western Michigan University, Kalamazoo, Michigan, USA.

Empirical literature exploring the reproductive health experiences of middle-aged women is limited. Little is known about their experiences and decision-making processes related to reproductive health. The purpose of the Reproductive Health Seeking (RHS) study was to expand the understanding of reproductive health knowledge and influences impacting health decisions for middle-aged women. Read More

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Disparities in Breast Cancer Associated With African American Identity.

Am Soc Clin Oncol Educ Book 2021 Jun;41:e29-e46

Department of Surgery, Weill Cornell Medicine/New York Presbyterian Hospital Network, New York, NY.

Persistent disparities in the burden of breast cancer between African Americans and White Americans have been documented over many decades. Features characterizing breast cancer in the African American community include a 40% higher mortality rate, younger age distribution, greater advanced-stage distribution, increased risk of biologically aggressive disease such as the triple-negative phenotype, and increased incidence of male breast cancer. Public health experts, genetics researchers, clinical trialists, multidisciplinary oncology teams, and advocates must collaborate to comprehensively address the multifactorial etiology of and remedies for breast cancer disparities. Read More

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Mammographic Variation Measures, Breast Density, and Breast Cancer Risk.

AJR Am J Roentgenol 2021 Jun 23:1-10. Epub 2021 Jun 23.

Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Our previous work showed that variation measures, which represent breast architecture derived from mammograms, were significantly associated with breast cancer. For replication purposes, we examined the association of three variation measures (variation [V], which is measured in the image domain, and P and p [a normalized version of P], which are derived from restricted regions in the Fourier domain) with breast cancer risk in an independent population. We also compared these measures to volumetric density measures (volumetric percent density [VPD] and dense volume [DV]) from a commercial product. Read More

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Evaluation of neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume, and neutrophil/monocyte ratio in patients with benign breast lesions.

A Varman S Alkan

Bratisl Lek Listy 2021 ;122(7):489-492

Objectives: In this study, we aimed to demonstrate the relationship between he neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), neutrophil/monocyte rate (NMR) and mean platelet volume (MPV) in patients with BIRADS grades of benign breast lesions.

Background: In many recent studies, NLR, PLR, NMR and MPV change significantly in connection with chronic inflammation and are suggested for use as prognostic markers in some diseases. However, the relationship between the cancer probability of benign breast diseases and mentioned hematological parameters has not been investigated in any previous study. Read More

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January 2021

[During and after cancer: identification of high-risk nutritional situations].

Rev Prat 2021 Feb;71(2):155-159

"Équipe de recherche en épidémiologie nutritionnelle (EREN), UMR U1153 Inserm/U1125 Inrae/Cnam/université Paris-13- Sorbonne Paris-Nord  ; Centre de recherche en épidémiologie et statistiques, université de Paris (CRESS), Bobigny, France cancer recherche (Réseau NACRe), www.inrae.fr/nacre, Jouy-en-Josas, France".

"During and after cancer: identification of high-risk nutritional situations At the end of 2020, the French National Cancer Institute published a report presenting the state of knowledge on the impact of nutritional factors on clinical endpoints during or after cancer. This report is the result of a collective expertise by an expert group from the French Network for Nutrition And Cancer Research (NACRe Network, www.inrae. Read More

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February 2021

Mortality risk attributable to diurnal temperature range: a multicity study in Yunnan of southwest China.

Environ Sci Pollut Res Int 2021 Jun 23. Epub 2021 Jun 23.

Department of Preventive Medicine, Shantou University Medical College, Shantou, 515041, Guangdong, China.

We aimed to estimate the non-accidental and cause-specific mortality burden attributed to diurnal temperature range (DTR) and the relative contributions of low, high, and extremely low and extremely high DTR in Yunnan, southwest China. Furthermore, we explored the possible effect modification of the DTR-mortality association by season, sex, age, ethnicity, marital status, and occupation. A standard time-series quasi-Poisson regression model combined with a distributed lag nonlinear model was used to derive estimates of city-specific DTR-mortality associations, then random effects meta-analysis was used to pool the estimated city-specific overall cumulative DTR-mortality association, estimating empirical confidence intervals (eCIs). Read More

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Choosing Between Mastectomy and Breast-Conserving Therapy: Is Patient Distress an Influencing Factor?

Ann Surg Oncol 2021 Jun 23. Epub 2021 Jun 23.

Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.

Background: Breast-conserving therapy (BCT) offers oncologic outcomes similar to those of mastectomy, yet many patients, when provided the option, choose mastectomy. This study aimed to evaluate the relationship between patient-reported distress and surgical decisions and to determine factors predictive of choosing BCT versus mastectomy.

Methods: Patients with newly diagnosed breast cancer deemed candidates for BCT who completed a distress screen at their initial visit to an academic institution between 2016 and 2019 were retrospectively reviewed. Read More

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Assessment of All-Cause Cancer Incidence Among Individuals With Preeclampsia or Eclampsia During First Pregnancy.

JAMA Netw Open 2021 Jun 1;4(6):e2114486. Epub 2021 Jun 1.

Institut National de la Santé et de la Recherche Médicale UA11, Institut Desbrest d'Épidémiologie et de Santé Publique, University of Montpellier, Montpellier, France.

Importance: Preeclampsia or eclampsia (preeclampsia/eclampsia) during pregnancy induces major physiological changes and may be associated with specific cancer occurrences in later life. The current data regarding the association between preeclampsia/eclampsia and cancer are heterogeneous, and cancer risk after preeclampsia/eclampsia could be different depending on the organ. These uncertainties warrant reexamination of the association between preeclampsia/eclampsia and the risk of cancer overall and by specific cancer type. Read More

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Pluronic F127-micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer.

Nanomedicine (Lond) 2021 Jun 23. Epub 2021 Jun 23.

Drug Delivery & Targeting, CIBBIM-Nanomedicine, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035, Barcelona, Spain.

Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Citral-loaded micelles (CLM) were obtained using Pluronic F127 and its efficacy tested on the growth of four breast cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Read More

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The Effects of Kinect-Enhanced Lymphatic Exercise Intervention on Lymphatic Pain, Swelling, and Lymph Fluid Level.

Integr Cancer Ther 2021 Jan-Dec;20:15347354211026757

New York University Tandon School of Engineering, Brooklyn, NY, USA.

Background: (TOLF) intervention aims to promote lymph flow through therapeutic lymphatic exercises to relieve lymphatic pain, swelling, lymphedema symptoms, and to decrease lymph fluid levels among breast cancer survivors. To enhance the efficacy of the TOLF intervention, an innovative, intelligent, Kinect-enhanced lymphatic exercise intervention (Kinect-TOLF) was developed to teach patients to perform the lymphatic exercises correctly.

Objectives: This feasibility trial aimed to determine the feasibility, usability, and effects of the Kinect-TOLF on lymphatic pain, swelling, lymphedema symptoms, and lymph fluid levels. Read More

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Revisiting CCL-type chemokines in breast cancer and its milieu: Prominent targetable chemokines, CCL8 and CCL21.

Nese Unver

Biosci Rep 2021 Jun 23. Epub 2021 Jun 23.

Hacettepe Universitesi, Ankara, Turkey.

The patterns of chemokine expression play a decisive role in both breast cancer prognosis and metastasis. In a recent article published in Bioscience Reports 2020, "Bioinformatics identification of CCL8/21 as potential prognostic biomarkers in breast cancer microenvironment", Chen et al. presented that expression of both CCL8 and CCL21 among CCL-type chemokines is prominent for prognosis of the breast cancer, metastasis and chemoresistance. Read More

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Cross-species comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma.

Dis Model Mech 2021 Jun 23. Epub 2021 Jun 23.

Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.

Angiosarcoma (AS) is a highly aggressive tumor of blood and lymphatic vessels in humans that carries a poor prognosis. The rarity of AS, together with its heterogeneous nature, and locations (skin, breast, visceral organs and deep soft tissues), makes understanding the pathogenesis of AS challenging. Dogs and cats spontaneously develop hemangiosarcoma (HSA), an aggressive tumor that shares many histopathological and clinical similarities to AS. Read More

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Biological gel-based microchamber array for tumor cell proliferation and migration studies in well-controlled biochemical gradients.

Lab Chip 2021 Jun 23. Epub 2021 Jun 23.

Chongqing Key Laboratory of Soft Condensed Matter Physics and Smart Materials, College of Physics, Chongqing University, Chongqing 401331, China.

Breast cancer metastasis is a complex process controlled by multiple factors, including various cell-cell interactions, cell-environment coupling, and oxygen, nutrient and drug gradients that are intimately related to the heterogeneous breast tissue structure. In this study, we constructed a high-throughput in vitro biochip system containing an array of 642 microchambers arranged in a checkerboard configuration, with each chamber embedded in a composite extracellular matrix (ECM) composed of engineered collagen and Matrigel to mimic local heterogeneous environment in vivo. In addition, a controllable complex tetragonal chemical concentration profile can be achieved by imposing chemical compounds at the four boundaries of the chip, leading to distinct local nutrient and/or drug gradients in the individual microchambers. Read More

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Aerobic Fitness is a Predictor of Body Composition in Women With Breast Cancer at Diagnosis.

Clin Breast Cancer 2021 Jun 9;21(3):e245-e251. Epub 2020 Oct 9.

Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil; School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil; Faculty of Physical Education, University of Campinas, Campinas, São Paulo, Brazil. Electronic address:

Background: The objective of this study was to investigate the relationship of aerobic fitness (AF) at diagnosis, before treatment and its relationship with body composition, physical function, lipidic profile, comorbidities, tumor characteristics, and quality of life of women with breast cancer (BC) PATIENTS AND METHODS: This cross-sectional cohort study included 78 women with BC that were assessed before treatment. A 6-minute walk test was used to evaluate the subjects' AF, estimating the maximum oxygen consumption (VO) to classify the women with BC into 2 groups: good/excellent AF or fair/weak/very weak AF. Dual-energy x-ray absorptiometry was performed to assess body composition. Read More

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A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer.

Clin Breast Cancer 2021 Jun 5;21(3):199-204. Epub 2020 Oct 5.

Houston Methodist Cancer Center, Houston, TX; Houston Methodist Research Institute, Houston, TX. Electronic address:

Introduction: Chemotherapy eliminates most of the cancer cells except those with potential for self-renewal and tumor initiation, called cancer stem cells (CSCs). Chloroquine, through bioinformatics, was found to be a potential agent to target CSCs. We designed a phase II trial to test the efficacy and safety of chloroquine in combination with taxane or taxane-like chemotherapy agents in patients with advanced or metastatic breast cancer who are refractory to anthracycline-based chemotherapy. Read More

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The epigenetics of breast cancer - Opportunities for diagnostics, risk stratification and therapy.

Epigenetics 2021 Jun 23:1-13. Epub 2021 Jun 23.

Department of Hematology/Oncology/Stem Cell Transplantation, University of Freiburg, Freiburg, Germany.

The stage and molecular pathology-dependent prognosis of breast cancer, the limited treatment options for triple-negative carcinomas, as well as the development of resistance to therapies illustrate the need for improved early diagnosis and the development of new therapeutic approaches. Increasing data suggests that some answers to these challenges could be found in the area of epigenetics. In this study, we focus on the current research of the epigenetics of breast cancer, especially on the potential of epigenetics for clinical application in diagnostics, risk stratification and therapy. Read More

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A Machine Learning Approach to Differentiate Two Specific Breast Cancer Subtypes Using Androgen Receptor Pathway Genes.

Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211027900

Department of Pathology, 71185Peking University Cancer Hospital, Beijing, China.

Triple-negative breast cancer is a heterogeneous disease with different molecular and histological subtypes. The Androgen receptor is expressed in a portion of triple-negative breast cancer cases and the activation of the androgen receptor pathway is thought to be a molecular subtyping signature as well as a therapeutic target for triple-negative breast cancer. Thus, identification of the androgen receptor pathway status is important for both molecular characterization andclinical management. Read More

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