467,392 results match your criteria Breast Cancer

Therapeutic efficacy of antibody-drug conjugates targeting GD2-positive tumors.

J Immunother Cancer 2022 Jun;10(6)

Department of Immunology, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

Background: Both ganglioside GD2-targeted immunotherapy and antibody-drug conjugates (ADCs) have demonstrated clinical success as solid tumor therapies in recent years, yet no research has been carried out to develop anti-GD2 ADCs against solid tumors. This is the first study to analyze cytotoxic activity of clinically relevant anti-GD2 ADCs in a wide panel of cell lines with varying GD2 expression and their effects in mouse models of GD2-positive solid cancer.

Methods: Anti-GD2 ADCs were generated based on the GD2-specific antibody ch14. Read More

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Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.

Reprod Toxicol 2022 Jun 25. Epub 2022 Jun 25.

Department of Environmental Health Sciences, School of Public Health & Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA. Electronic address:

Work from numerous fields of study suggests that exposures to hormonally active chemicals during sensitive windows of development can alter mammary gland development, function, and disease risk. Stronger links between many environmental pollutants and disruptions to breast health continue to be documented in human populations, and there remain concerns that the methods utilized to identify, characterize, and prioritize these chemicals for risk assessment and risk management purposes are insufficient. There are also concerns that effects on the mammary gland have been largely ignored by regulatory agencies. Read More

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Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicine.

Ann Oncol 2022 Jun 25. Epub 2022 Jun 25.

Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Womens Research Institute, Pittsburgh, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, USA; Institute for Precision Medicine, University of Pittsburgh and UPMC, Pittsburgh, USA. Electronic address:

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A peptoid-based inhibitor of Protein Arginine Methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells.

J Biol Chem 2022 Jun 25:102205. Epub 2022 Jun 25.

Department of Chemistry, University of North Florida, Jacksonville, FL, U.S.A.

Protein Arginine Methyltransferases (PRMTs) are S-adenosylmethionine (SAM)-dependent enzymes that transfer a methyl group to arginine residues within proteins, most notably histones. The nine characterized PRMT family members are divided into three types depending on the resulting methylated product: asymmetric dimethylarginine (ADMA; Type I PRMT), symmetric dimethylarginine (SDMA; Type II PRMT), or monomethylated arginine (MMA; Type III PRMT). In some cancers, the resulting product can lead to either increased or decreased transcription of cancer-related genes, suggesting PRMT family members may be valid therapeutic targets. Read More

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Diagnostic value of sST2, VCAM-1 and adiponectin in patients with breast cancer to predict anti-tumor treatment-related cardiac events: A pilot study.

Oncol Res Treat 2022 Jun 28. Epub 2022 Jun 28.

Aim The present exploratory study investigated the diagnostic value of inflammatory markers in patients with breast cancer to predict anti-tumour treatment-related cardiac events. Methods Twenty-one patients with breast cancer were enrolled in this prospective observational study and followed over 6 months. Transthoracic echocardiography and measurement of cardiac (N terminal prohormone of brain natriuretic peptide (NT proBNP), Troponin I (TnI)) and inflammatory biomarkers (vascular adhesion molecule 1 (VCAM-1), soluble suppression of tumorigenesis-2 (sST2), adiponectin) was performed at 3-month intervals (baseline, follow-up, final visit). Read More

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A systematic assessment of online international breast density information.

Breast 2022 Jun 22;65:23-31. Epub 2022 Jun 22.

Wiser Healthcare, Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council NSW, Sydney, Australia.

Background: Breast density has become a topic of international discussion due to its associated risk of breast cancer. As online is often a primary source of women's health information it is therefore essential that breast density information it is understandable, accurate and reflects the best available evidence. This study aimed to systematically assess online international breast density information including recommendations to women. Read More

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IGDQ motogenic peptide gradient induces directional cell migration through integrin (αv)β3 activation in MDA-MB-231 metastatic breast cancer cells.

Neoplasia 2022 Jun 25;31:100816. Epub 2022 Jun 25.

URBC - NARILIS, University of Namur, rue de Bruxelles 61, 5000 Namur, Belgium. Electronic address:

In the context of breast cancer metastasis study, we have shown in an in vitro model of cell migration that IGDQ-exposing (IsoLeu-Gly-Asp-Glutamine type I Fibronectin motif) monolayers (SAMs) on gold sustain the adhesion of breast cancer MDA-MB-231 cells by triggering Focal Adhesion Kinase and integrin activation. Such tunable scaffolds are used to mimic the tumor extracellular environment, inducing and controlling cell migration. The observed migratory behavior induced by the IGDQ-bearing peptide gradient along the surface allows to separate cell subpopulations with a "stationary" or "migratory" phenotype. Read More

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Cadinane-type sesquiterpenoid dimeric diastereomers hibisceusones A-C from infected stems of Hibiscus tiliaceus with cytotoxic activity against triple-negative breast cancer cells.

Bioorg Chem 2022 Jun 23;127:105982. Epub 2022 Jun 23.

Hainan Branch Institute of Medicinal Plant Development (Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine), Chinese Academy of Medical Sciences & Peking Union Medical College, Haikou 570311, China; Institute of Medicinal Plant Development (Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription, Chinese Academy of Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical College, No. 151, Malianwa North Road, Haidian District, Beijing 100193, China. Electronic address:

Three new cadinane-type sesquiterpenoid dimeric diastereomers (1-3) named hibisceusones A-C were obtained from the infected stems of Hibiscus tiliaceus. The structures were determined by NMR spectroscopy and MS techniques, and the absolute configurations were assigned by ECD and single-crystal X-ray diffraction techniques. Compounds 1-3 are diastereomers, and contain a 1,4-dioxane ring linearly fused to different cadinane-type polycyclic skeletons. Read More

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Atezolizumab With Neoadjuvant Anti-Human Epidermal Growth Factor Receptor 2 Therapy and Chemotherapy in Human Epidermal Growth Factor Receptor 2-Positive Early Breast Cancer: Primary Results of the Randomized Phase III IMpassion050 Trial.

J Clin Oncol 2022 Jun 28:JCO2102772. Epub 2022 Jun 28.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Combining standard of care (pertuzumab-trastuzumab [PH], chemotherapy) with cancer immunotherapy may potentiate antitumor immunity, cytotoxic activity, and patient outcomes in high-risk, human epidermal growth factor receptor 2 (HER2)-positive early breast cancer. We report the phase III IMpassion050 primary analysis of neoadjuvant atezolizumab, PH, and chemotherapy in these patients.

Methods: Patients with a primary tumor of > 2 cm and histologically confirmed, positive lymph node status (T2-4, N1-3, M0) were randomly assigned 1:1 to atezolizumab/placebo with dose-dense doxorubicin/cyclophosphamide, followed by paclitaxel, and PH. Read More

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Expression of PD-L1 in Locally Advanced Breast Cancer and Its Impact on Neoadjuvant Chemotherapy Response.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):2095-2103. Epub 2022 Jun 1.

Department of Pathology, National Cancer Institute, Cairo University, Egypt.

Objectives: Programmed cell death-ligand 1 (PD-L1) is a new target in breast cancer (BC) and its impact on neoadjuvant chemotherapy (NACTH) response is still unclear. The aim of this study was to investigate the prevalence of PD-L1 in locally advanced invasive BC of different molecular subtypes and to elucidate its relation to tumor-infiltrating lymphocytes (TILs) density, established clinicopathological factors, pathological therapy response after neoadjuvant chemotherapy and patients' outcome.

Materials And Methods: One hundred and five cases of locally advanced invasive BC were enrolled in our study. Read More

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Effects of ERCC5 rs751402 Polymorphism on Oxidative Stress and the Impact of Curcumin on Catalase Activity in Breast Carcinogenesis.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):2065-2070. Epub 2022 Jun 1.

Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Rangsit Campus, Patumthani, Thailand.

Background: Breast cancer is a complex multifactorial disease and polymorphisms in nucleotide excision repair pathway are associated with the potential risk of breast cancer. Pathological processes linked to breast cancer are associated with oxidative stress. Catalase plays an essential role in cell defense against oxidative stress. Read More

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Pathogenicity Reclassification of Genetic Variants Related to Early-Onset Breast Cancer among Women of Mongoloid Origin.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):2027-2033. Epub 2022 Jun 1.

Department of Molecular oncology and Immunology, Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Science, Tomsk, Russia.

Background: Germline alterations in BRCA1, BRCA2, and other genes are responsible for early-onset breast cancer. However, up to 20% of molecular tests report genetic variant of unknown significance (VUS) or novel variants that have never been previously described and their clinical significance are unknown. This study aimed to reclassify variant of unknown significance (VUS) or novel variants by using the ActiveDriveDB database that annotates variants through the lens of sites of post-translational modifications (PTM). Read More

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Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):1847-1858. Epub 2022 Jun 1.

Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Cimetidine and ibuprofen exhibit immunomodulatory effects as an antagonist of histamine H2 receptor, and a cyclooxygenase inhibitor, respectively. Here, the effects of cimetidine and ibuprofen on some effector T cell-related parameters were investigated using a breast cancer (BC) model. BC was established in Balb/c mice using the 4T1 cell line. Read More

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Long-term follow-up on morbidity among women with a history of gestational diabetes mellitus: a systematic review.

J Clin Endocrinol Metab 2022 Jun 28. Epub 2022 Jun 28.

Center for Epidemiological Research, Nykøbing Falster Hospital, Nykøbing Falster, Denmark.

Background: Gestational diabetes mellitus (GDM) complicates up to 10% of pregnancies and is a well-known risk factor of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Little is known about possible long-term risks of other diseases. The aim was to review the literature for evidence of associations with morbidity other than T2DM and cardiovascular disease and with long-term mortality. Read More

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Knowledge of breast cancer and breast self-examination practices and its barriers among university female students in Bangladesh: Findings from a cross-sectional study.

PLoS One 2022 28;17(6):e0270417. Epub 2022 Jun 28.

Centre for Research on Health Policy, Torrens University Australia, Adelaide, Australia.

Early diagnosis of breast cancer is the best approach towards its control that may result in alleviating related mortality and morbidity. This study aimed to evaluate knowledge about breast cancer and both practices and perceived barriers to breast self-examination among female university students in Bangladesh. A cross-sectional study was carried out with 400 female students of Jahangirnagar University, Bangladesh. Read More

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Joint Localization and Classification of Breast Cancer in B-Mode Ultrasound Imaging via Collaborative Learning with Elastography.

IEEE J Biomed Health Inform 2022 Jun 28;PP. Epub 2022 Jun 28.

Convolutional neural networks (CNNs) have been successfully applied in the computer-aided ultrasound diagnosis for breast cancer. Up to now, several CNN-based methods have been proposed. However, most of them consider tumor localization and classification as two separate steps, rather than performing them simultaneously. Read More

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Multiple roles of ghrelin in breast cancer.

Int J Biol Markers 2022 Jun 28:3936155221110247. Epub 2022 Jun 28.

176759Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Breast cancer is one of the most threatening malignant tumors in women worldwide; hence, investigators are continually performing novel research in this field. However, an accurate prediction of its prognosis and postoperative recovery remains difficult. The severity of breast cancer is patient-specific and affected by several health factors; thus, unknown mechanisms may affect its progression. Read More

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Hemorrhage Risk Among Patients With Breast Cancer Receiving Concurrent Direct Oral Anticoagulants With Tamoxifen vs Aromatase Inhibitors.

JAMA Netw Open 2022 Jun 1;5(6):e2219128. Epub 2022 Jun 1.

Department of Medicine, University of Ottawa at the Ottawa Hospital, Ottawa, Ontario, Canada.

Importance: Tamoxifen is commonly used as adjuvant therapy in breast cancer and is proposed to interfere with cytochrome P450 enzyme and P-glycoprotein pathways. Concurrent use with direct oral anticoagulants (DOACs) poses the threat of a potentially dangerous drug-drug interaction by leading to an increase in hemorrhage risk.

Objective: To assess the risk of hemorrhage in patients with breast cancer coprescribed a DOAC and tamoxifen compared with a DOAC and an aromatase inhibitor (AI). Read More

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Impact of artificial intelligence in breast cancer screening with mammography.

Breast Cancer 2022 Jun 28. Epub 2022 Jun 28.

Department of Radiology, Valenciennes Hospital Center, 114 Avenue Desandrouin, 59300, Valenciennes, France.

Objectives: To demonstrate that radiologists, with the help of artificial intelligence (AI), are able to better classify screening mammograms into the correct breast imaging reporting and data system (BI-RADS) category, and as a secondary objective, to explore the impact of AI on cancer detection and mammogram interpretation time.

Methods: A multi-reader, multi-case study with cross-over design, was performed, including 314 mammograms. Twelve radiologists interpreted the examinations in two sessions delayed by a 4 weeks wash-out period with and without AI support. Read More

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Sentinel Lymph Node Biopsy Alone is Adequate for Chemotherapy Decisions in Postmenopausal Early-Stage Hormone-Receptor-Positive, HER2-Negative Breast Cancer with One to Three Positive Sentinel Lymph Nodes.

Ann Surg Oncol 2022 Jun 28. Epub 2022 Jun 28.

Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Background: The RxPONDER trial randomized patients with cT1-3N0 hormone receptor-positive, HER2-negative (HRHER2) breast cancer and one to three positive nodes and Recurrence Score (RS) < 26 to endocrine therapy (ET) or chemoendocrine therapy (CET) with equivalent survival in postmenopausal women. In current practice, cN0 patients with one or two positive sentinel lymph nodes (SLN) do not undergo axillary lymph node dissection (ALND), raising concerns about applying these data in patients who may have additional nodal disease.

Methods: We identified institutional [Dana-Farber Brigham Cancer Center (DF/BCC), 2016-2020] and national [National Cancer Database (NCDB), 2012-2017] cohorts of women aged 50-75 years with cT1-3N0 HRHER2 breast cancer and RS < 26 treated with upfront surgery with one to three positive SLN. Read More

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Expression of ERBB gene family in females with breast cancer and its correlation with clinicopathological characteristics of the disease.

Mol Biol Rep 2022 Jun 28. Epub 2022 Jun 28.

Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

Background: Breast cancer (BC) is the most prevalent and fatal cancer in women. Given that there are very few studies investigating the overexpression of four members of ERBB genes, we decided to investigate the correlation between these four genes with clinicopathological characteristics in breast cancer cases.

Methods: Tumoural tissue of 50 patients with sporadic invasive ductal BC was recruited. Read More

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Surgical margin status and survival outcomes of breast cancer patients treated with breast-conserving surgery and whole-breast irradiation after neoadjuvant chemotherapy.

Breast Cancer Res Treat 2022 Jun 28. Epub 2022 Jun 28.

Division of Breast Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: The definition of "no tumor on ink" is generally applied for clear resection margin (RM) after breast-conserving surgery (BCS). However, few studies reported the effect of RM in the setting of neoadjuvant chemotherapy (NAC). We investigated the association between RM status and survival outcomes for those who underwent BCS after NAC for breast cancer. Read More

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Prediction of tumor metastasis extracellular vesicles-treated platelet adhesion on a blood vessel chip.

Lab Chip 2022 Jun 28. Epub 2022 Jun 28.

Center for Soft and Living Matter, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea.

In preclinical and clinical studies, it has been demonstrated that tumor-educated platelets play a critical role in tumorigenesis, cancer development, and metastasis. Unlike the role of cancer-derived chemokines in platelet activation, the role of cancer-derived extracellular vesicles (EVs) has remained elusive. Here, we found that interleukin-8 (IL-8) in cancer-derived EVs contributed to platelet activation by increasing P-selectin expression and ligand affinity, resulting in increased platelet adhesion on the human vessel-mimicking microfluidic system. Read More

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Breast cancer.

JAAPA 2022 Jul;35(7):57-59

At the time this article was written, Donna La May Newman was a student in the Primary Care Physician Assistant Program at the University of Southern California's (USC) Keck School of Medicine in Los Angeles, Calif. She now practices in outpatient internal medicine at Kaiser Permanente's Baldwin Park (Calif.) Medical Center, is co-visionary and an adjunct primary care provider at Community 43's integrative mental wellness outpatient clinic in Phoenix, Ariz., and practices with Alliance Urgent Care in the Greater Phoenix area. Irminne Van Dyken practices in general surgery at Kaiser Permanente's Wailuku Ambulatory General Surgery Clinic in Maui, Hawaii. Darryl Mayo teaches clinical family medicine in USC's Primary Care Physician Assistant Program. The authors have disclosed no potential conflicts of interest, financial or otherwise.

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Breast cancer risk predictions by birth cohort and ethnicity in a population-based screening mammography program.

Br J Radiol 2022 Jun 28:20211388. Epub 2022 Jun 28.

University of British Columbia Okanagan, Kelowna BC, Canada.

Objectives: To examine whether birth cohorts affect the risk of breast cancer for East Asian, First Nations, African, South Asian and Caucasian ethnicities in British Columbia (BC).

Methods: We used Cox PH models adjusted for well-known risk factors, such as age, breast density, mammographic features on false positives, and family history, to examine risk of breast cancer among East Asian, First Nations, African and South Asian ethnicities, relative to Caucasian, across three birth cohorts.

Results: There were 813,280 participants and 11,166 and invasive breast cancer diagnoses. Read More

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Editorial for "TP53 Mutation Estimation Based on Radiomics Analysis for Breast Cancer".

J Magn Reson Imaging 2022 Jun 28. Epub 2022 Jun 28.

Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

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pH-responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for delivery of Anderson-type Polyoxomolybdate in Breast Cancer.

J Microencapsul 2022 Jun 28:1-43. Epub 2022 Jun 28.

Novel Drug Delivery Systems Research Center and Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences and, Isfahan University of Medical Sciences, Isfahan, Iran.

Aim: This study aimed to develop novel pH-sensitive Glucosamine (Glu) targeted Polydopamine (PDA) coated mesoporous silica (SBA-15) nanoparticles (NPs) for selective delivery of anticancer Anderson-type manganese polyoxomolybdate (POMo) to breast cancer.

Methods: The [email protected] NPs were prepared via direct hydrothermal synthesis of SBA, POMo loading, in situ PDA post functionalization, and Glu anchoring; the chemical structures were fully studied by different characterization methods. The anticancer activity was studied by MTT method and Annexin V-FITC apoptosis detection kit. Read More

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Evaluation of the effect of nitrate and chloride on Cd(II)-induced cell oxidative stress by scanning electrochemical microscopy.

Anal Methods 2022 Jun 28. Epub 2022 Jun 28.

Center of Excellence for Environmental Safety and Biological Effects, Department of Chemistry and Biology, Beijing University of Technology, Beijing 100124, P. R. China.

Cadmium (Cd) is one of the most prevalent toxic metal pollutants, which is widely distributed in various environmental media and organisms. Literature studies have documented that Cd could stimulate cellular oxidative stress, and the increased intracellular reactive oxygen species (ROS) might destroy certain proteins and DNA and subsequently lead to cell apoptosis. Although several studies have studied the co-exposure between cadmium and other metals, information on the potential effects of Cd and its counterions is still lacking. Read More

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Syntaxin 7 contributes to breast cancer cell invasion by promoting invadopodia formation.

J Cell Sci 2022 Jun 28;135(12). Epub 2022 Jun 28.

Department of Biological Sciences, Indian Institute of Science Education and Research, Bhopal, Bhopal 462066, India.

Invasion in various cancer cells requires coordinated delivery of signaling proteins, adhesion proteins, actin-remodeling proteins and proteases to matrix-degrading structures called invadopodia. Vesicular trafficking involving SNAREs plays a crucial role in the delivery of cargo to the target membrane. Screening of 13 SNAREs from the endocytic and recycling route using a gene silencing approach coupled with functional assays identified syntaxin 7 (STX7) as an important player in MDA-MB-231 cell invasion. Read More

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An Evaluation of Metabolic, Dietetic, and Nutritional Status Reveals Impaired Nutritional Outcomes in Breast Cancer Patients.

Nutr Cancer 2022 Jun 28:1-12. Epub 2022 Jun 28.

Department of Health Sciences, Ribeirão Preto Medical School, University of São Paulo (USP), São Paulo, Brazil.

Nutritional status can change in breast cancer patients after treatment. However, the metabolic implications of those alterations are poorly understood. We used a cross-sectional study design to compare body composition, lipids, glucose levels, and adiposity indices in breast cancer patients with a matched control and a healthy group. Read More

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