380,392 results match your criteria Breast Cancer


Patient-reported symptoms following mastectomy alone or lumpectomy plus radiation for early stage breast cancer: a cohort study.

Breast Cancer Res Treat 2019 Mar 16. Epub 2019 Mar 16.

Cancer Care Ontario, Toronto, Canada.

Purpose: Studies examining symptom differences between surgeries for breast cancer patients rarely incorporate the effects of adjuvant treatment choice. We sought to understand differences in patient-reported symptoms between lumpectomy plus radiation and mastectomy in the year following surgery.

Methods: This cohort study used linked administrative datasets. Read More

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http://dx.doi.org/10.1007/s10549-019-05196-xDOI Listing
March 2019
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Differences in clinicopatholgic characteristics and risk of mortality between the triple positive and ER+/PR+/HER2- breast cancer subtypes.

Cancer Causes Control 2019 Mar 16. Epub 2019 Mar 16.

Sutter Institute for Medical Research, 2801 Capitol Ave, Suite 400, Sacramento, CA, 95816, USA.

Purpose: This study compared the demographic and clinicopathologic characteristics and risk of mortality between the triple positive (TP) and ER+/PR+/HER2- breast cancer subtypes.

Methods: Cases of first primary female invasive TP and ER+/PR+/HER2- breast cancer were obtained from the California Cancer Registry. Logistic regression analysis was used to compare differences in factors associated with the TP versus the ER+/PR+/HER2- subtype. Read More

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http://dx.doi.org/10.1007/s10552-019-01152-8DOI Listing

Importance of m N-methyladenosine (mA) RNA modification in cancer.

Med Oncol 2019 Mar 16;36(4):36. Epub 2019 Mar 16.

Department of Medical Genetics, Faculty of Medicine, Near East University, 99138, Nicosia, Cyprus.

RNA methylation, which was identified back in 1970s, has gained remarkable interest in recent years as it was shown to be a reversible modification involved in many cellular processes like mRNA and miRNA processing, mRNA localisation, translation suppression, or activation. These, in turn, affect important bioprocesses such as tissue development, sex determination, and DNA damage response. Important group of proteins are responsible for adding, recognizing, and removing the methyl group to and from the RNA molecules, which are referred as writers, readers, and erasers, respectively. Read More

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http://dx.doi.org/10.1007/s12032-019-1260-6DOI Listing

Tumor dormancy at bedside: A late awakening.

Breast 2019 Mar 2;45:61-63. Epub 2019 Mar 2.

Unit of Medical Statistics, Biometry and Bioinformatics "Giulio A. Maccacaro", Department of Clinical Sciences and Community Health, University of Milan Campus Cascina Rosa, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Breast cancer recurrence may occur at variable times following primary tumor removal. The corresponding event dynamics displays a structured multipeak pattern, which can be explained by the occurrence of microscopic phases of metastasis quiescence (tumor dormancy) followed by wake up, growth and timed clinical appearance. This model provides a meaningful justification of the early recurrence pattern and even explains the effectiveness of adjuvant systemic therapies. Read More

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http://dx.doi.org/10.1016/j.breast.2019.03.001DOI Listing

The comparative study of the DNA binding and biological activities of the quaternized dicnq as a dicationic form and its platinum(II) heteroleptic cationic complex.

Bioorg Chem 2019 Mar 7;87:70-77. Epub 2019 Mar 7.

Department of Chemistry, Faculty of Arts and Sciences, Zonguldak Bulent Ecevit University, Zonguldak 67100, Turkey. Electronic address:

The square-planar heteroleptic Pt(II) coordination compound [Pt(bpy)(dicnq)](NO) (1) and the quaternized dicnq ligand, namely 12,13-dicyano-5,6-dihydrodipyrazino[2,3-f:1',2',3',4'-lmn][1,10]phenanthroline-4,7-diium dibromide (2) (Fig. 1) were synthesized and fully characterized by means of FTIR, NMR, MALDI-TOF MS and the purity was confirmed by CHN analyses. The DNA binding profiles of 1 and 2 were identified in an identical condition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00452068183139
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http://dx.doi.org/10.1016/j.bioorg.2019.03.009DOI Listing
March 2019
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Characterizing the Effects of Radiation Dermatitis on Quality of Life: A Prospective Survey-Based Study.

J Am Acad Dermatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Medicine, Division of Dermatology, Albert Einstein College of Medicine, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.03.011DOI Listing

Lactate dehydrogenase A regulates autophagy and tamoxifen resistance in breast cancer.

Biochim Biophys Acta Mol Cell Res 2019 Mar 13. Epub 2019 Mar 13.

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India. Electronic address:

Estrogen receptor (ER) antagonist, tamoxifen has been universally used for the treatment of the ER-positive breast cancer; however, inevitable emergence of resistance to tamoxifen obstructs the successful treatment of this cancer. So, there is an immediate requirement for the search of a novel therapeutic target for treatment of this cancer. Acquired tamoxifen resistant breast cancer cell lines MCF-7 (MCF-7/TAM-R) and T47D (T47D/TAM-R) showed higher apoptotic resistance accompanied by induction of pro-survival autophagy compared to their parental cells. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2019.03.004DOI Listing

Size-Adjustable Micelles Co-loaded with Chemotherapeutic Agent and Autophagy Inhibitor for Enhancing Cancer Treatment via Increasing Tumor Retention.

Acta Biomater 2019 Mar 13. Epub 2019 Mar 13.

Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, China. Electronic address:

Autophagy plays a key role in the stress response of tumor cells, which contributes to cancer cell survival and resistance to chemotherapy by degrading cytoplasmic proteins to provide energy and clear the hazardous substances. Therefore, combined treatment of chemotherapeutics and autophagy inhibitors is thought to obtain a desirable antitumor effect. Nanoparticles (NPs) show potential in tumor-targeting drug delivery because of the enhanced permeability and retention (EPR) effect. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.03.022DOI Listing

Breast Arterial Calcium: A Game Changer in Women's Cardiovascular Health?

JACC Cardiovasc Imaging 2019 Mar 8. Epub 2019 Mar 8.

Department of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins Medical Institutions, Baltimore, Maryland; Cardiology Department, Bellvitge University Hospital and Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona, Spain; Research Triangle Institute Health Solutions, Pharmacoepidemiology and Risk Management, Barcelona, Spain. Electronic address:

In 2018, cardiovascular disease (CVD) was the leading cause of death among women, and current CVD prevention paradigms may not be sufficient in this group. In that context, it has recently been proposed that detection of calcification in breast arteries may help improve CVD risk screening and assessment in apparently healthy women. This review provides an overview of breast arterial anatomy; and the epidemiology, pathophysiology, and measurement of breast artery calcium (BAC); and discusses the features of the BAC-CVD link. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.07.035DOI Listing
March 2019
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MiR-155-3p acts as a tumor suppressor and reverses paclitaxel resistance via negative regulation of MYD88 in human breast cancer.

Gene 2019 Mar 13. Epub 2019 Mar 13.

Department of Biochemistry and Molecular Biology, Bengbu Medical College, Anhui 233030, China. Electronic address:

MiR-155-3p, which is derived from the same pre-miRNA as miR-155-5p, the latter has been reported to be dysregulated in multiple tumor tissues and associated with clinicopathologic markers, tumor subtypes, and poor survival rates. However, the biological effects of miR-155-3p are rarely explored. In this study, we find that miR-155-3p was down-regulated in breast cancer and MYD88 was validated as the target for miR-155-3p. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.066DOI Listing

A Reappraisal of the Comparative Effectiveness of Lumpectomy Versus Mastectomy on Breast Cancer Survival: A Propensity Score-Matched Update From the National Cancer Data Base (NCDB).

Clin Breast Cancer 2019 Feb 21. Epub 2019 Feb 21.

Gundersen Health System, La Crosse, WI.

Background: Recent observational studies are concerning because they document rising mastectomy rates coinciding with more than a dozen reports that lumpectomy has better overall survival (OS) than mastectomy. Our aim was to determine if there were differences in OS of matched breast cancer patients undergoing lumpectomy versus mastectomy in the National Cancer Database (NCDB).

Patients And Methods: A retrospective cohort of patients with stage I-III breast cancer in the NCDB (2004-2013) was identified. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.02.006DOI Listing
February 2019

Understanding the type of support offered within the caregiver, family, and spiritual/religious contexts of cancer patients.

J Pain Symptom Manage 2019 Mar 13. Epub 2019 Mar 13.

Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, USA. Electronic address:

Context/objectives: We sought to characterize patterns of social support types (i.e. emotional, informational, appraisal and instrumental) within the caregiver/spouse, family and spiritual/religious contexts for patients diagnosed with cancer. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.03.003DOI Listing

Surgery and adjuvant radiotherapy for unilateral ductal carcinoma in situ (DCIS) in women aged over 70 years: A population based cohort study.

Eur J Surg Oncol 2019 Mar 7. Epub 2019 Mar 7.

Clinical Effectiveness Unit, The Royal College of Surgeons of England, London, UK; Department of Health Services Research & Policy, London School of Hygiene & Tropical Medicine, London, UK.

Background: There is little clinical evidence to guide treatment decisions for ductal carcinoma in situ (DCIS) in older women. This study evaluated how the management of DCIS in women aged 70 or more compared with women aged 50-69 in England and Wales.

Method: The study identified women aged ≥50 years with new unilateral DCIS diagnosed between 2014 and 2016 from linked cancer registration and routine hospital datasets for England and Wales. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.02.034DOI Listing

Impact of exercise on chemotherapy completion rate: A systematic review of the evidence and recommendations for future exercise oncology research.

Crit Rev Oncol Hematol 2019 Apr 16;136:79-85. Epub 2019 Feb 16.

Rehabilitation Sciences Graduate Program, University of British Columbia, Vancouver, BC, Canada; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Receipt of full chemotherapy dose is associated with improved treatment efficacy and survival following a diagnosis of cancer. Exercise has emerged as a supportive care intervention that may improve chemotherapy completion rate by managing dose-limiting toxicities. We conducted a systematic review to evaluate the impact of exercise interventions on outcomes of chemotherapy completion rate in adult cancer patients. Read More

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http://dx.doi.org/10.1016/j.critrevonc.2019.02.005DOI Listing

Modern radiotherapy in cancer treatment during pregnancy.

Crit Rev Oncol Hematol 2019 Apr 11;136:13-19. Epub 2019 Feb 11.

Radiation Oncology, IRCCS Sacro Cuore Don Calabria Hospital, Negrar-Verona, Italy; University of Brescia, Italy.

Breast cancer, gynecological malignancies and lymphomas are the most frequently diagnosed tumors in pregnant women. The feasibility of radiotherapy during pregnancy remains a subject of debate and clinicians continue to hesitate on this approach, trying to avoid radiotherapy in most cases. Since the 1990s, several technological advances, including intensity modulated and image guided radiation delivery, have been implemented in radiation oncology to improve the radiation treatment in terms of effectiveness and tolerability. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10408428193003
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http://dx.doi.org/10.1016/j.critrevonc.2019.02.002DOI Listing
April 2019
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Prognostic Impact of Src, CDKN1B, and JAK2 Expression in Metastatic Breast Cancer Patients Treated with Trastuzumab.

Transl Oncol 2019 Mar 13;12(5):739-748. Epub 2019 Mar 13.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, University Campus, Building 17B, 54006, Thessaloniki, Greece; Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece. Electronic address:

Background: Src, CDKN1B, and JAK2 play a crucial role in the coordination of cell signaling pathways. In the present study, we aim to investigate the prognostic significance of these biomarkers in HER2-positive metastatic breast cancer (MBC) patients treated with trastuzumab (T).

Methods: Formalin-fixed paraffin-embedded tumor tissue samples from 197 patients with HER2-positive MBC treated with T were retrospectively collected. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.02.010DOI Listing

Development of clay-protein based composite nanoparticles modified single-used sensor platform for electrochemical cytosensing application.

Biosens Bioelectron 2019 Mar 5;132:230-237. Epub 2019 Mar 5.

Advanced Technologies Application and Research Center, Hacettepe University, Ankara, Turkey; Chemistry Department, Analytical Chemistry Division, Hacettepe University, 06800 Beytepe, Ankara, Turkey. Electronic address:

A novel sensor platform modified with clay-protein based composite nanoparticles (Mt-HSA NCs) was developed to be used in electrochemical cytosensing application for the first time. The nanocomposite synthesized with desolvation method was structurally clarified by various characterization methods. Then, the working electrode was constructed by modifying the surface of the disposable pencil graphite (PGE) with physical adsorption to perform a simple sensor system. Read More

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http://dx.doi.org/10.1016/j.bios.2019.02.058DOI Listing

Secondary breast angiosarcoma: A multicentre retrospective survey by the national Italian association of Breast Surgeons (ANISC).

Breast 2019 Mar 7;45:56-60. Epub 2019 Mar 7.

IEO, Milano, Italy.

Background: Breast angiosarcoma is a malignant mesenchymal neoplasm, which accounts for approximately 2% of all soft tissue sarcomas. Secondary breast angiosarcoma (SBA) may be related to chronic lymphedema after a mastectomy with lymph node dissection (Stewart Treves syndrome) and previous radiotherapy for complications from breast radiation treatment. It is a very rare condition; therefore, diagnosis and management are still a challenge. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09609776193003
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http://dx.doi.org/10.1016/j.breast.2019.02.011DOI Listing
March 2019
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Feasibility of a mindful yoga program for women with metastatic breast cancer: results of a randomized pilot study.

Support Care Cancer 2019 Mar 15. Epub 2019 Mar 15.

Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Box 90399, Durham, NC, 27708, USA.

Purpose: Patients with metastatic breast cancer (MBC) experience high levels of symptoms. Yoga interventions have shown promise for improving cancer symptoms but have rarely been tested in patients with advanced disease. This study examined the acceptability of a comprehensive yoga program for MBC and the feasibility of conducting a randomized trial testing the intervention. Read More

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http://dx.doi.org/10.1007/s00520-019-04710-7DOI Listing

Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.

Mol Cell Biochem 2019 Mar 15. Epub 2019 Mar 15.

Departamento de Biologia Celular, Cinvestav-IPN, Av. IPN # 2508, 07360, Mexico, DF, Mexico.

Linoleic acid (LA) is an essential and omega-6 polyunsaturated fatty acid that mediates a variety of biological processes, including migration and invasion in breast cancer cells. Phospholipase D (PLD) catalyses the hydrolysis of phosphatidylcholine to produce phosphatidic acid and choline. Increases of expression and activity of PLD are reported in several human cancers, including gastric, colorectal, renal, stomach, lung and breast. Read More

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http://dx.doi.org/10.1007/s11010-019-03517-8DOI Listing

Digital Breast Tomosynthesis for Intraoperative Margin Assessment during Breast-Conserving Surgery.

Ann Surg Oncol 2019 Mar 14. Epub 2019 Mar 14.

Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Intraoperative margin assessment for breast cancer patients undergoing segmental mastectomy (SM) enables identification of positive margins, with immediate excision of additional tissue to obtain negative margins.

Objective: The aim of this study was to determine the ability of digital breast tomosynthesis (DBT) to detect positive margins compared with an institution's standard extensive processing (SEP).

Methods: SM specimens underwent intraoperative SEP with two-dimensional (2D) imaging of the intact and sliced specimen, with review by a breast radiologist and gross assessment by a breast pathologist. Read More

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http://dx.doi.org/10.1245/s10434-019-07226-wDOI Listing

Does family communication matter? Exploring knowledge of breast cancer genetics in cancer families.

J Community Genet 2019 Mar 15. Epub 2019 Mar 15.

Department of Epidemiology - School of Public Health, Rutgers University, Piscataway, NJ, 08854, USA.

Knowledge of breast cancer genetics is critical for those at increased hereditary risk who must make decisions about breast cancer screening options. This descriptive study explored theory-based relationships among cognitive and emotional variables related to knowledge of breast cancer genetics in cancer families. Participants included first-degree relatives of women with breast cancer who had received genetic counseling and testing. Read More

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http://dx.doi.org/10.1007/s12687-019-00413-yDOI Listing

Factors associated with willingness to provide biospecimens for genetics research among African American cancer survivors.

J Community Genet 2019 Mar 14. Epub 2019 Mar 14.

College of Medicine Alcohol Research Center, Howard University, Washington, DC, USA.

This study evaluated factors associated with willingness to provide biospecimens for cancer genetic research among African American cancer survivors. A total of 200 African American adults diagnosed with breast, colon, and/or prostate cancers completed a self-administered survey. Family history information, beliefs about cancer research, cancer genetics and disparities knowledge, willingness to provide a biospecimen, and demographics were obtained. Read More

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http://dx.doi.org/10.1007/s12687-019-00411-0DOI Listing

Postchemotherapy hippocampal functional connectivity patterns in patients with breast cancer: a longitudinal resting state functional MR imaging study.

Brain Imaging Behav 2019 Mar 15. Epub 2019 Mar 15.

Department of Medical Imaging, Jinling Hospital,Nanjing Medical University, 305 Zhongshan East Road, Xuanwu District, Nanjing, 210002, Jiangsu, China.

The hippocampus plays a key role in cognitive function and emotion regulation due to its wide connection with the whole brain. This study examined the acute effect of chemotherapy on hippocampal and subfield functional connectivity and neuropsychological status in breast cancer patients (BC). This IRB approved study included 29 BC and 25 age matched healthy controls (HCs) who underwent resting state functional magnetic resonance imaging (Rs-fMRI), neuropsychological tests and blood examinations at baseline and one week after completing chemotherapy or in the same time interval. Read More

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http://dx.doi.org/10.1007/s11682-019-00067-xDOI Listing

C677T and A1298C methylenetetrahydrofolate reductase polymorphisms and breast cancer susceptibility among Latinos: a meta-analysis.

Breast Cancer 2019 Mar 15. Epub 2019 Mar 15.

Departamento de Genética, Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2901 Col. Volcanes, C.P. 72420, Puebla, Pue, Mexico.

Background: Previous meta-analyses have shown an ethnic dependency of the C677T and the A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms, with no focus on the Latino population. For Latinos, many studies have examined these polymorphisms and breast cancer susceptibility, yielding no concise result. Therefore, we undertook this meta-analysis to determine the effect these polymorphisms have on breast cancer risk for Latinos. Read More

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http://dx.doi.org/10.1007/s12282-019-00961-8DOI Listing

Multiview Contouring for Breast Tumor on Magnetic Resonance Imaging.

J Digit Imaging 2019 Mar 15. Epub 2019 Mar 15.

Department of Computer Science, Tunghai University, Taichung, Taiwan.

The shape and contour of the lesion are shown to be effective features for physicians to identify breast tumor as benign or malignant. The region of the lesion is usually manually created by the physician according to their clinical experience; therefore, contouring tumors on breast magnetic resonance imaging (MRI) is difficult and time-consuming. For this purpose, an automatic contouring method for breast tumors was developed for less burden in the analysis and to decrease the observed bias to help in making decisions clinically. Read More

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http://dx.doi.org/10.1007/s10278-019-00190-7DOI Listing

Sentinel and non-sentinel lymph node metastases in patients with microinvasive breast cancer: a nationwide study.

Breast Cancer Res Treat 2019 Mar 14. Epub 2019 Mar 14.

Department of Breast Surgery, Rigshospitalet/Herlev-Gentofte Hospital, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.

Purpose: To determine the incidence and risk factors of sentinel lymph node (SN) and non-SN metastases in patients with microinvasive breast cancer (MIBC, T1). This to identify MIBC patients in whom axillary staging can be safely omitted.

Methods: The Danish Breast Cancer Group database was used to identify a total of 409 women with breast cancer ≤ 1 mm who underwent sentinel lymph node biopsy (SLNB) between 2002 and 2015. Read More

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http://dx.doi.org/10.1007/s10549-019-05200-4DOI Listing

Malignancies associated with GIST: a retrospective study with molecular analysis of KIT and PDGFRA.

Langenbecks Arch Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Pathology, FAU Erlangen-Nürnberg, Erlangen, Germany.

Purpose: Gastrointestinal stromal tumors (GISTs) are the most common soft tissue tumors of the GI tract. Studies have been published reporting additional neoplasms in GIST patients. This study aimed to evaluate possible associations of mutation type, morphology, and clinical aspects of GISTs. Read More

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http://dx.doi.org/10.1007/s00423-019-01773-2DOI Listing

p27 transcriptionally coregulates cJun to drive programs of tumor progression.

Proc Natl Acad Sci U S A 2019 Mar 15. Epub 2019 Mar 15.

Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136;

p27 shifts from CDK inhibitor to oncogene when phosphorylated by PI3K effector kinases. Here, we show that p27 is a cJun coregulator, whose assembly and chromatin association is governed by p27 phosphorylation. In breast and bladder cancer cells with high p27pT157pT198 or expressing a CDK-binding defective p27pT157pT198 phosphomimetic (p27CK-DD), cJun is activated and interacts with p27, and p27/cJun complexes localize to the nucleus. Read More

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http://dx.doi.org/10.1073/pnas.1817415116DOI Listing

Inequalities in Financial Distress, Symptoms, and Quality of Life Among Patients with Advanced Cancer in France and the U.S.

Oncologist 2019 Mar 15. Epub 2019 Mar 15.

Department of Supportive and Palliative Care, Centre Hospitalier Lyon-Sud, Lyon, France.

Background: Financial distress (FD) is common among patients with advanced cancer. Our purpose was to compare the frequency and intensity of FD and its associations with symptom distress and quality of life (QOL) in these patients in France and the U.S. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0353DOI Listing

Pan-TAM tyrosine kinase inhibitor BMS-777607 enhances anti-PD-1 mAb efficacy in a murine model of triple-negative breast cancer.

Cancer Res 2019 Mar 15. Epub 2019 Mar 15.

Department of Cell Biology and Molecular Medicine, Rutgers, Biomedical and Health Sciences Center.

Tyro3, Axl, and Mertk (abbreviated TAM) represent a family of homologous tyrosine kinase receptors known for their functional role in phosphatidylserine (PS)-dependent clearance of apoptotic cells and also for their immune modulatory functions in the resolution of inflammation. Previous studies in our laboratory have shown that Gas6/PS-mediated activation of TAM receptors on tumor cells leads to subsequent upregulation of PD-L1, defining a putative PS->TAM receptor->PD-L1 inhibitory signaling axis in the cancer microenvironment that may promote tolerance. In this study, we tested combinations of TAM inhibitors and PD-1 mAbs in a syngeneic orthotopic E0771 murine triple-negative breast cancer model, whereby tumor-bearing mice were treated with pan-TAM kinase inhibitor (BMS-777607) or anti-PD-1 alone or in combination. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2614DOI Listing

Gamma Knife Radiosurgery for the Management of Greater than 15 Cerebral Metastases.

World Neurosurg 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurological Surgery and the Center for Image-Guided Neurosurgery, Pittsburgh, PA.

Background: The number of metastases that can be treated safely and effectively with Gamma Knife® stereotactic radiosurgery (GKSRS) remains controversial despite continuing evidence to support its expanded utilization. We endeavored to elucidate the survival outcomes for patients who presented with ≥15 brain metastases at the time of initial SRS.

Methods: This retrospective analysis reviewed patients treated for ≥15 brain metastases originating from breast cancer, lung cancer, or melanoma. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.019DOI Listing

Cyanidin-3-glucoside induces mesenchymal to epithelial transition via activating Sirt1 expression in triple negative breast cancer cells.

Biochimie 2019 Mar 12. Epub 2019 Mar 12.

Department of Clinical Nutrition, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Electronic address:

Triple-negative breast cancer (TNBC) is a heterogeneous group of breast cancer with one common feature: distinctly metastatic nature with higher rate of relapse and shorter survival compared with other subtypes of breast cancer. The epithelial to mesenchymal transition (EMT) is highly associated with cancer metastasis. Cyanidin-3-glucoside (C3G), the most abundant anthocyanin pigment enriched in fresh fruits and vegetables, showed ideal anti-oxidant property. Read More

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http://dx.doi.org/10.1016/j.biochi.2019.03.004DOI Listing

Prophylactic Versus Therapeutic Mastectomy: A Contemporary Analysis of the ACS-NSQIP Database.

Clin Breast Cancer 2019 Jan 31. Epub 2019 Jan 31.

Division of Surgical Oncology, Department of Surgery, University of Massachusetts, Worcester, MA. Electronic address:

Introduction: The objective of the study was to evaluate the morbidity, mortality, and postoperative outcomes associated with simple or subcutaneous mastectomy in the management of prophylactic versus therapeutic resection. In this study we aimed to assess if simple or subcutaneous mastectomy for prophylaxis affects perioperative outcomes compared with resection performed for biopsy proven malignancy.

Materials And Methods: The American College of Surgeons National Surgical Quality Improvement Program database was queried for subjects who underwent simple or subcutaneous mastectomy between 2007 and 2012. Read More

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http://dx.doi.org/10.1016/j.clbc.2019.01.008DOI Listing
January 2019

Risk factors for skip metastasis and lateral lymph node metastasis of papillary thyroid cancer.

Surgery 2019 Mar 12. Epub 2019 Mar 12.

Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Lymph node metastases from papillary thyroid cancer is believed to disseminate sequentially, first to the central neck and later to the lateral neck. Skip metastases of papillary thyroid cancer, however, are defined as lateral lymph node metastasis without central lymph node metastasis. The aim of this study was to investigate the risk factors for skip metastases and lateral lymph node metastasis of papillary thyroid cancer. Read More

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http://dx.doi.org/10.1016/j.surg.2019.01.025DOI Listing

Detection of KRAS G12D point mutation level by anchor-like DNA electrochemical biosensor.

Authors:
Ni Zeng Juan Xiang

Talanta 2019 Jun 31;198:111-117. Epub 2019 Jan 31.

Hunan Provincial Key Laboratory of Efficient and Clean Utilization of Manganese Resources, Central South University, Changsha 410083, Hunan, PR China; College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, PR China. Electronic address:

KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer. Here, we developed a novel anchor-like DNA (alDNA) electrochemical sensor for the detection of KRAS point mutation level (the concentration ratio of the specific KRAS point mutant DNA (M-DNA) to the total DNA (t-DNA) of both mutant and wild-type DNAs carrying the same allele). Compared to those conventional ligation-based DNA sensors, the proposed alDNA sensor achieved the one-step capture of both wild-type and mutant DNA, and the subsequent detection on one chip, which effectively decreased systematic errors from the uncertain differences on the interfacial structural and microenvironmental changes, improved the detection accuracy. Read More

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http://dx.doi.org/10.1016/j.talanta.2019.01.105DOI Listing

Stromal integrin α11-deficiency reduces interstitial fluid pressure and perturbs collagen structure in triple-negative breast xenograft tumors.

BMC Cancer 2019 Mar 15;19(1):234. Epub 2019 Mar 15.

Department of Biomedicine, University of Bergen, P.O. Box 7804, 5020, Bergen, Norway.

Background: Cancer progression is influenced by a pro-tumorigenic microenvironment. The aberrant tumor stroma with increased collagen deposition, contractile fibroblasts and dysfunctional vessels has a major impact on the interstitial fluid pressure (PIF) in most solid tumors. An increased tumor PIF is a barrier to the transport of interstitial fluid into and within the tumor. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5449-zDOI Listing
March 2019
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CoCl simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis.

Biol Res 2019 Mar 15;52(1):12. Epub 2019 Mar 15.

Department of Zoology, Institute of Science, Banaras Hindu University, Varanasi, U. P., 221005, India.

Background/aims: Hypoxia microenvironment plays a crucial role during tumor progression and it tends to exhibit poor prognosis and make resistant to various conventional therapies. HIF-1α acts as an important transcriptional regulator directly or indirectly associated with genes involved in cell proliferation, angiogenesis, apoptosis and energy metabolism during tumor progression in hypoxic microenvironment. This study was aimed to investigate the expression pattern of the hypoxia associated genes and their association during breast cancer progression under hypoxic microenvironment in breast cancer cells. Read More

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http://dx.doi.org/10.1186/s40659-019-0221-zDOI Listing

Communicating prognosis to women with early breast cancer - overview of prediction tools and the development and pilot testing of a decision aid.

BMC Health Serv Res 2019 Mar 15;19(1):171. Epub 2019 Mar 15.

MIN Faculty, Health Sciences and Education, University of Hamburg, Martin-Luther-King Platz 6, D-20146, Hamburg, Germany.

Background: Shared decision-making in oncology requires information on individual prognosis. This comprises cancer prognosis as well as competing risks of dying due to age and comorbidities. Decision aids usually do not provide such information on competing risks. Read More

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http://dx.doi.org/10.1186/s12913-019-3988-2DOI Listing

Cancer burden in the Caribbean: an overview of the Martinique Cancer Registry profile.

BMC Cancer 2019 Mar 15;19(1):239. Epub 2019 Mar 15.

CHU Martinique, Pôle de Cancérologie Hématologie, Urologie Pathologie, CHU Martinique, Fort-de-France, Martinique.

Background: Cancer indicators are essential information for cancer surveillance and cancer research strategy development. The Martinique Cancer Registry (MCR) is a population-based cancer Registry (PBCR) that has been recording cancer data since its creation in 1981. This article provides cancer incidence and mortality data for all cancers and for major tumor sites. Read More

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http://dx.doi.org/10.1186/s12885-019-5434-6DOI Listing

Identifying miRNA-mRNA regulatory relationships in breast cancer with invariant causal prediction.

BMC Bioinformatics 2019 Mar 15;20(1):143. Epub 2019 Mar 15.

School of Information Technology and Mathematical Sciences, University of South Australia, Adelaide, Australia.

Background: microRNAs (miRNAs) regulate gene expression at the post-transcriptional level and they play an important role in various biological processes in the human body. Therefore, identifying their regulation mechanisms is essential for the diagnostics and therapeutics for a wide range of diseases. There have been a large number of researches which use gene expression profiles to resolve this problem. Read More

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http://dx.doi.org/10.1186/s12859-019-2668-xDOI Listing

EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models.

Molecules 2019 Mar 15;24(6). Epub 2019 Mar 15.

New Therapeutic Targets Laboratory (TargetsLab)-Oncology Unit, Department of Medical Sciences, Faculty of Medicine, University of Girona, Emili Grahit 77, 17003 Girona, Spain.

Recent studies showed that Fatty Acid Synthase (FASN), a lipogenic enzyme overexpressed in several carcinomas, plays an important role in drug resistance. Furthermore, the enrichment of Breast Cancer Stem Cell (BCSC) features has been found in breast tumors that progressed after chemotherapy. Hence, we used the triple negative breast cancer (TNBC) cell line MDA-MB-231 (231) to evaluate the FASN and BCSC population role in resistance acquisition to chemotherapy. Read More

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http://dx.doi.org/10.3390/molecules24061027DOI Listing

5-Iodo-4-thio-2'-Deoxyuridine as a Sensitizer of X-ray Induced Cancer Cell Killing.

Int J Mol Sci 2019 Mar 15;20(6). Epub 2019 Mar 15.

Faculty of Chemistry, University of Gdańsk, Wita Stwosza 63, 80-308 Gdańsk, Poland.

Nucleosides, especially pyrimidines modified in the C5-position, can act as radiosensitizers via a mechanism that involves their enzymatic triphosphorylation, incorporation into DNA, and a subsequent dissociative electron attachment (DEA) process. In this paper, we report 5-iodo-4-thio-2'-deoxyuridine (ISdU) as a compound that can effectively lead to ionizing radiation (IR)-induced cellular death, which is proven by a clonogenic assay. The test revealed that the survival of cells, pre-treated with 10 or 100 µM solution of ISdU and exposed to 0. Read More

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http://dx.doi.org/10.3390/ijms20061308DOI Listing

Diagnostic and Prognostic Significance of Carboxypeptidase A4 (CPA4) in Breast Cancer.

Biomolecules 2019 Mar 14;9(3). Epub 2019 Mar 14.

Department of Surgery, Institute of Oncology, Istanbul University, 34093 Istanbul, Turkey.

Recent research focused on prolonged survival has suggested that carboxypeptidase A4 (CPA4) plays a role in both tumor microenvironment formation and distant metastasis in cancer. In some patients, serum and expression (mRNA) levels of CPA4 have been found to be correlated with the aggressiveness and progression of the disease. Accordingly, we conducted a first study to investigate the diagnostic and prognostic significance of CPA4 in the case of breast cancer (BC), the most common form of malignancy in women. Read More

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http://dx.doi.org/10.3390/biom9030103DOI Listing

Baicalein Suppresses Stem Cell-Like Characteristics in Radio- and Chemoresistant MDA-MB-231 Human Breast Cancer Cells through Up-Regulation of IFIT2.

Nutrients 2019 Mar 14;11(3). Epub 2019 Mar 14.

Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju 63243, Korea.

Resistance to both chemotherapy and radiation therapy is frequent in triple-negative breast cancer (TNBC) patients. We established treatment-resistant TNBC MDA-MB-231/IR cells by irradiating the parental MDA-MB-231 cells 25 times with 2 Gy irradiation and investigated the molecular mechanisms of acquired resistance. The resistant MDA-MB-231/IR cells were enhanced in migration, invasion, and stem cell-like characteristics. Read More

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http://dx.doi.org/10.3390/nu11030624DOI Listing

Discoveries beyond BRCA1/2: Multigene testing in an Asian multi-ethnic cohort suspected of hereditary breast cancer syndrome in the real world.

PLoS One 2019 15;14(3):e0213746. Epub 2019 Mar 15.

Department of Hematology-Oncology, National University Cancer Institute, Singapore, Singapore.

Background: Due to historically low uptake of genetic testing, the mutational spectrum of Asians with Hereditary Breast Cancer (HBC) is not well understood. This study sought to understand the incidence and spectrum of germline mutations in Asian patients with suspected HBC in a clinic setting.

Methods: 1056 patients with suspected HBC were seen in our Cancer (CA) Genetics Clinic from 2000-2017, of which 460 underwent genetic testing. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213746PLOS

Induction of AMPK activation by N,N'-diarylurea FND-4b decreases growth and increases apoptosis in triple negative and estrogen-receptor positive breast cancers.

PLoS One 2019 15;14(3):e0209392. Epub 2019 Mar 15.

Lucille Parker Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America.

Purpose: Triple negative breast cancer (TNBC) is the most lethal and aggressive subtype of breast cancer. AMP-activated protein kinase (AMPK) is a major energy regulator that suppresses tumor growth, and 1-(3-chloro-4-((trifluoromethyl)thio)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea (FND-4b) is a novel AMPK activator that inhibits growth and induces apoptosis in colon cancer. The purpose of this project was to test the effects of FND-4b on AMPK activation, proliferation, and apoptosis in breast cancer with a particular emphasis on TNBC. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209392PLOS

Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic.

PLoS Genet 2019 Mar 15;15(3):e1007530. Epub 2019 Mar 15.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.

A common complementary strategy in Genome-Wide Association Studies (GWAS) is to perform Gene Set Analysis (GSA), which tests for the association between one phenotype of interest and an entire set of Single Nucleotide Polymorphisms (SNPs) residing in selected genes. While there exist many tools for performing GSA, popular methods often include a number of ad-hoc steps that are difficult to justify statistically, provide complicated interpretations based on permutation inference, and demonstrate poor operating characteristics. Additionally, the lack of gold standard gene set lists can produce misleading results and create difficulties in comparing analyses even across the same phenotype. Read More

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http://dx.doi.org/10.1371/journal.pgen.1007530DOI Listing
March 2019
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Analyzing bioactive effects of the minor hop compound xanthohumol C on human breast cancer cells using quantitative proteomics.

PLoS One 2019 15;14(3):e0213469. Epub 2019 Mar 15.

Bavarian Center for Biomolecular Mass Spectrometry, TUM School of Life and Food Sciences Weihenstephan, Technical University of Munich, Freising, Germany.

Minor prenylated hop compounds have been attracting increasing attention due to their promising anticarcinogenic properties. Even after intensive purification from natural raw extracts, allocating certain activities to single compounds or complex interactions of the main compound with remaining impurities in very low concentration is difficult. In this study, dose-dependent antiproliferative and cytotoxic effects of the promising xanthohumol (XN) analogue xanthohumol C (XNC) were evaluated and compared to XN and a XN-enriched hop extract (XF). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213469PLOS
March 2019
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