Search Our Scientific Publications & Authors

J Cutan Pathol 2021 Jun 5. Epub 2021 Jun 5.

Department of Breast Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Syringocystadenocarcinoma papilliferum (SCACP) is a rare cutaneous adnexal tumor thought to originate from its benign counterpart, syringocystadenoma papilliferum. These tumors are predominantly located on the head and neck with their location on the breast extraordinarily reported; mammary localization poses a great diagnostic dilemma to the practicing pathologist. Herein, we report an unusual case of an 85-year-old woman with an outside diagnosis on a core needle biopsy of metaplastic mammary carcinoma. Read More

Expert Rev Med Devices 2021 Apr 29:1-8. Epub 2021 Apr 29.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.

: Percutaneous image-guided biopsy is the procedure of choice for diagnosing suspicious abnormalities on breast imaging. Stereotactic, ultrasound, and magnetic resonance imaging are used for image-guided breast biopsies. Stereotactic guidance uses mammography to localize lesions and facilitate placement of a core biopsy needle. Read More

Tumori 2021 Mar 24:3008916211002260. Epub 2021 Mar 24.

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Background: Although most breast masses in children are benign, breast cancer must be considered in the differential diagnosis. The majority are represented by sarcomas and secondary lesions. Literature reports only four cases of neuroblastoma breast metastasis, with no emphasis on radiologic features. Read More

Adv Clin Exp Med 2021 Mar;30(3):273-278

Breast Unit, Division of Breast Surgery, Lower Silesian Oncology Center, Wrocław, Poland.

Background: The Sentimag hand-held probe detects the magnetic response from iron oxide particles trapped in a sentinel node.

Objectives: To investigate if an electromagnetic probe can be helpful in the identification of a hook wire tip located in an occult breast lesion.

Material And Methods: Forty-two patients undergoing lumpectomy without axillary procedure were enrolled. Read More

Ann Surg Oncol 2021 Mar 6. Epub 2021 Mar 6.

Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Needle localization of a marking clip is required to guide accurate removal of many breast lesions. When the clip is not visualized on specimen radiography, concerns regarding the completeness of cancer removal and long-term outcomes arise. Using a large cohort of women undergoing breast conservation, we examined the magnitude of the problem and the outcome of women with a missing clip. Read More

Ultrasound Obstet Gynecol 2021 Feb 15. Epub 2021 Feb 15.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objective: To evaluate the feasibility and clinical applications of Fusion Virtual Navigation of F-FDG PET/CT (PET/CT) and ultrasound images in assessing superficial lymph nodes in breast and gynecological cancer patients.

Methods: This is a single-center pilot study. Consecutive patients with breast or gynecological cancer with abnormal uptake of axillary or groin lymph nodes on PET/CT scan, also submitted to ultrasound assessment, were enrolled between January 2017 and May 2019. Read More

Med Phys 2021 Apr 2;48(4):1859-1873. Epub 2021 Mar 2.

Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, N6A 3K7, Canada.

Purpose: Image-guided needle biopsy of small, detectable lesions is crucial for early-stage diagnosis, treatment planning, and management of breast cancer. High-resolution positron emission mammography (PEM) is a dedicated functional imaging modality that can detect breast cancer independent of breast tissue density, but anatomical context and real-time needle visualization are not yet available to guide biopsy. We propose a mechatronic guidance system integrating an ultrasound (US)-guided core-needle biopsy (CNB) with high-resolution PEM localization to improve the spatial sampling of breast lesions. Read More

Med Phys 2021 Mar 8;48(3):1299-1306. Epub 2021 Feb 8.

Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA.

Purpose: To develop a scheme to quantitatively assess localization accuracy of tomosynthesis-guided vacuum-assisted breast biopsy apparatus.

Methods: A phantom containing a metallic pellet on a flexible plastic shaft was constructed and was tested in cranio-caudal (CC) and lateral (LAT) arm biopsy geometries following the standard clinical breast biopsy workflow. Three points were manually digitized on tomosynthesis images including: the center of the target, and the tip of the needle in pre- and postfire positions. Read More

Radiologe 2021 Feb 11;61(2):159-165. Epub 2021 Jan 11.

Abteilung für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Tübingen, Tübingen, Deutschland.

Background: Interventional methods of the breast serve as percutaneous minimally invasive diagnostic tools in case of suspicious findings in the breast or axilla. Further indications are lesion localization and the minimally invasive therapeutic approach.

Objectives: Aim of this paper is to give an overview of the existing methods, their indications and the imaging techniques for guidance. Read More

Cancers (Basel) 2020 Nov 30;12(12). Epub 2020 Nov 30.

Neoplasia & Endocrine Differentiation P0L5, Centro de Investigación en Medicina Moleculary Enfermedades Crónicas (CIMUS), Instituto de Investigación Sanitaria (IDIS), University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.

Multiplex immunohistochemistry (mIHC) use markers staining different cell populations applying widefield optical microscopy. Resolution is low not resolving subcellular co-localization. We sought to colocalize markers at subcellular level with antibodies validated for clinical diagnosis, including the single secondary antibody (combination of anti-rabbit/mouse-antibodies) used for diagnostic IHC with any primary antibody, and confocal microscopy. Read More

Int J Surg Case Rep 2020 31;77:325-328. Epub 2020 Oct 31.

Gynecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V, Rabat, Morocco.

Introduction: The hydatid cyst of the breast is a rare pathology even in countries endemic to tuberculosis, however there remains a differential diagnosis evoked in front of any breast tumor. The clinic, mammography and ultrasound sometimes allow us to suspect the hydatid nature of the lesion. The definitive diagnosis remains histological and the treatment is always surgical. Read More

Ann Surg Oncol 2021 Jun 10;28(6):3223-3229. Epub 2020 Nov 10.

Department of Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Background: As an alternative to traditional wire localization, an inducible magnetic seed system can be used to identify and remove nonpalpable breast lesions and axillary lymph nodes intraoperatively. We report the largest single-institution experience of magnetic seed placement for operative localization to date, including feasibility and short-term outcomes.

Methods: Patients who underwent placement of a magnetic seed in the breast or lymph node were identified from July 2017 to March 2019. Read More

Eur Radiol 2021 May 30;31(5):2645-2656. Epub 2020 Oct 30.

Radiology Unit, Department of Pathology and Diagnostics, Azienda Ospedaliera Universitaria Integrata - Verona, P.le Stefani 1, 37126, Verona, Italy.

Objectives: This study evaluated the feasibility of DWI for lesion targeting in MRI-guided breast biopsies. Furthermore, it assessed device positioning on DWI during biopsy procedures.

Methods: A total of 87 biopsy procedures (5/87 bilateral) consecutively performed between March 2019 and June 2020 were retrospectively reviewed: in these procedures, a preliminary DWI sequence (b = 1300 s/mm) was acquired to assess lesion detectability. Read More

AJR Am J Roentgenol 2020 10 21. Epub 2020 Oct 21.

Massachusetts General Hospital, Department of Radiology, 55 Fruit Street, WAC 240, Boston, MA 02114.

Advantages of radiofrequency Tags for pre-operative breast lesion localization include decoupling of placement from surgical schedules and improved patient comfort. To evaluate the feasibility of a pre-operative localization radiofrequency Tag system for breast lesions requiring surgical excision. The cohort for this retrospective study comprised consecutive patients who underwent image-guided needle localization with radiofrequency Tags (Faxitron; Hologic, Arizona) before surgical excision from July 2018 to July 2019. Read More

Br J Radiol 2020 Oct 24;93(1114):20200495. Epub 2020 Jul 24.

Department of Radiology, Mayo Clinic, Rochester, MN, United States.

As tomosynthesis is rapidly adopted by breast imaging practices, tomosynthesis-guided procedures are increasingly being performed. Tomosynthesis-guided needle localizations are feasible and efficient and allow for localization of tomosynthesis-only findings or one-view findings, which may be difficult to localize under standard digital mammography. In this review, we describe our step-by-step approach for performing tomosynthesis-guided localizations of the breast and axilla using a standard tomosynthesis unit. Read More

J Cancer 2020 20;11(16):4671-4682. Epub 2020 May 20.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

With a high sensitivity of breast lesions, MRI can detect suspicious lesions which are occult in traditional breast examination equipment. However, the lower and variable specificity of MRI makes the MRI-guided intervention, including biopsies and localizations, necessary before surgery, especially for patients who need the treatment of breast-conserving surgery (BCS). MRI techniques and patient preparation should be first carefully considered before the intervention to avoid lengthening the procedure time and compromising targeting accuracy. Read More

Minerva Chir 2020 Aug 26;75(4):255-259. Epub 2020 May 26.

Department of Surgical Oncology, University of Perugia, Perugia, Italy.

Background: Non-palpable breast lesions are more frequent now than in the past due to the attention toward the mammary pathology and the screening diffusion; the marking of such lesions is very important for a successful surgery. The SentiMag System uses a magnetic marker that is inoculated transdermal in the breast through an 18-gauge needle.

Methods: Between April 1^st and June 30^th, 2018, 16 patients with non-palpable breast lesions were selected and subjected to surgery using the SentiMag System in our Unit. Read More

Folia Med (Plovdiv) 2020 03;62(1):23-30

Military Medical Academy, Sofia, Bulgaria.

Introduction: Although the liver and lung are the most frequently affected organs in cystic echinococcosis, the cysts may develop in any viscera and tissues. Breast is a rare primary localization with few cases described in the literature. We present an updated and systematic review and discuss the possible mechanisms of spreading, diagnostic and treatment options. Read More

Int J Comput Assist Radiol Surg 2020 Apr 25;15(4):681-690. Epub 2020 Feb 25.

Robotics and Mechatronics, University of Twente, Enschede, The Netherlands.

Purpose: The biopsy procedure is an important phase in breast cancer diagnosis. Accurate breast imaging and precise needle placement are crucial in lesion targeting. This paper presents an end-effector (EE) for robotic 3D ultrasound (US) breast acquisitions and US-guided breast biopsies. Read More

3D Print Med 2020 Feb 18;6(1). Epub 2020 Feb 18.

Department of Radiology, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH, 45267, USA.

Background: Breast cancer is the most commonly diagnosed malignancy in females and frequently requires core needle biopsy (CNB) to guide management. Adequate training resources for CNB suffer tremendous limitations in reusability, accurate simulation of breast tissue, and cost. The relatively recent advent of 3D printing offers an alternative for the development of breast phantoms for training purposes. Read More

Clin Imaging 2020 Mar 12;60(1):100-108. Epub 2019 Dec 12.

The University of Texas MD Anderson Cancer Center, Department of Breast Imaging, 1155 Pressler, Unit 1350, CPB 5.3208, Houston, TX 77030, USA.

In patients with nonpalpable early-stage breast cancer eligible for breast conservation surgery (BCS), wire-guided localization (WGL) is widely accepted as a standard technique for preoperative image-guided lesion localization. In preparation for this procedure, lesion location, size, type and configuration play important roles in preoperative localization planning. Successful preoperative planning requires review of all pertinent imaging studies, imaging reports and pathology reports, with special attention to pre- and post-biopsy imaging and evaluation of the targeted lesions and the type and the position of the marker clips. Read More

J Pak Med Assoc 2019 Oct;69(10):1501-1504

Department of Clinical pathology, INMOL Hospital, Lahore, Pakistan.

Objective: To determine the outcome of sonographically-guided indigenous low-cost metallic clip placement for tumour localisation in patients of early breast cancer undergoing neoadjuvant chemotherapy. .

Methods: The prospective analytical study was conducted at the Institute of Nuclear Medicine and Oncology, Lahore, Pakistan, from May 2016 to December 2017, and comprised biopsy-proven breast cancer cases. Read More

AJNR Am J Neuroradiol 2019 11 3;40(11):1960-1964. Epub 2019 Oct 3.

From the Section of Neuroradiology (T.H.V., M.K., S.A., M.G.-M., M.M.C., J.M.D., B.E.-M.).

The use of transoral sonography-guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. Read More

Breast 2019 Oct 23;47:93-101. Epub 2019 Jul 23.

Breast Surgery Unit, Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 263, 00029, HUS, Finland.

Objectives: The aim of this retrospective study is to compare surgical margins, reoperation rates and local recurrences after breast conserving surgery (BCS) using radioguided occult lesion localization (ROLL) or radioactive seed localization (RSL).

Materials And Methods: We reviewed 744 consecutive patients with impalpable primary invasive breast cancer who underwent BCS at Helsinki University Hospital between 2010 and 2012. ROLL was used in our unit until October 31st, 2011; from November 1st we changed localization method to RSL. Read More

Perm J 2019 14;23. Epub 2019 Jun 14.

Department of Surgery, Oakland Medical Center, CA.

Context: Preoperative wire localization (WL), the most common localization technique for nonpalpable breast lesions, has drawbacks including scheduling constraints, cost, and patient discomfort.

Objective: To reduce WL use in our health care system, we investigated using hydrogel clips to facilitate intraoperative ultrasonography-guided lumpectomies.

Design: We retrospectively reviewed electronic medical records of patients with nonpalpable, ultrasound-visible breast lesions who underwent lumpectomy by 7 surgeons at 4 pilot sites in Kaiser Permanente Northern California between January 2015 and October 2015. Read More

World J Surg Oncol 2019 May 27;17(1):88. Epub 2019 May 27.

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: To retrospectively analyze perilesional technetium Tc-99m MAA injection for intraoperative localization of atypical soft-tissue and bone lesions within a single tertiary referral center in order to determine technique, safety, and clinical utility of these procedures.

Methods: An IRB compliant, retrospective electronic chart review (2010-2017) exploring surgical excision of atypical (non-pulmonary, non-breast, non-sentinel node) lesions guided by Tc-99m MAA perilesional injection. Patient demographics, lesion location, lesion size, radiotracer injection technique, radiotracer injection complications, scintigraphy technique, scintigraphic quality, intraoperative time, lesion identification in surgery, and pathological diagnoses were recorded. Read More

Ultrasonography 2019 Jul 8;38(3):272-276. Epub 2019 Jan 8.

Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.

Purpose: Absorbable retaining thread (ART) needle localization utilizes a guiding needle with a thread; this technique was invented to reduce patient discomfort and wire migration. We investigated the feasibility of ultrasound (US)-guided ART needle localization for nonpalpable breast lesions.

Methods: ART needle localization was performed for 26 nonpalpable breast lesions in 26 patients who were scheduled to undergo surgical excision the day after localization. Read More

Acad Radiol 2020 02 7;27(2):204-209. Epub 2019 May 7.

University of Texas MD Anderson Cancer, Department of Diagnostic Radiology, Division of Diagnostic Imaging, 1515 Holcombe Blvd., Unit 1350, Houston, TX 77030.

Rationale And Objectives: The goal of this retrospective study was to evaluate the rate of immediate post-biopsy clip migration on an upright digital tomosynthesis-guided vacuum-assisted core biopsy unit and determine if any factors were associated with immediate clip migration.

Materials And Methods: We performed a retrospective review of patients who had undergone a biopsy performed at one facility from November 1, 2014 to September 30, 2016. Post-biopsy mammograms were reviewed to assess immediate clip position relative to the targeted lesion. Read More

Ginekol Pol 2019 ;90(3):122-127

University Center for Breast Diseases, University Hospital in Cracow, Poland.

Objectives: The aims of the study were as follows: 1) to determine the applicability of vacuum-assisted core needle biopsy in the diagnosis and management of intraductal papillomas of the breast; 2) to define factors which increase the risk for underestimation of breast cancer.

Material And Methods: Between 2002-2017, a total of 222 cases of intraductal papillomas were diagnosed in one center (201 using vacuum-assisted core-needle ultrasound-guided biopsy and 21 using stereotactic biopsy). All patients under- went scheduled follow-up imaging. Read More

Breast J 2019 05 28;25(3):479-483. Epub 2019 Mar 28.

Department of Radiology, UT MD Anderson Cancer Center, Houston, Texas.

We describe the history of, indications for, and techniques involved in MRI-guided needle localization (MRI-NL). MRI-NL continues to be a safe, effective method of sampling lesions that are only detected with MRI, particularly for anatomically challenging lesions such as those near the chest wall, the nipple, the skin, and/or in close proximity to implants. Read More