Search Our Scientific Publications & Authors

J Cancer 2020 20;11(16):4671-4682. Epub 2020 May 20.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

With a high sensitivity of breast lesions, MRI can detect suspicious lesions which are occult in traditional breast examination equipment. However, the lower and variable specificity of MRI makes the MRI-guided intervention, including biopsies and localizations, necessary before surgery, especially for patients who need the treatment of breast-conserving surgery (BCS). MRI techniques and patient preparation should be first carefully considered before the intervention to avoid lengthening the procedure time and compromising targeting accuracy. Read More

Minerva Chir 2020 May 26. Epub 2020 May 26.

Surgical Oncology, University of Perugia, Perugia, Italy.

Background: Non-palpable breast lesions are more frequent now than in the past due to the attention toward the mammary pathology and the screening diffusion; the marking of such lesions is very important for a successful surgery. The SentiMag system uses a magnetic marker that is inoculated transdermal in the breast through an 18-gauge needle.

Methods: Between April 1st and June 30th 2018, 16 patients with non-palpable breast lesions were selected and subjected to surgery using the Sentimag System in our Unit. Read More

Int J Comput Assist Radiol Surg 2020 Apr 25;15(4):681-690. Epub 2020 Feb 25.

Robotics and Mechatronics, University of Twente, Enschede, The Netherlands.

Purpose: The biopsy procedure is an important phase in breast cancer diagnosis. Accurate breast imaging and precise needle placement are crucial in lesion targeting. This paper presents an end-effector (EE) for robotic 3D ultrasound (US) breast acquisitions and US-guided breast biopsies. Read More

3D Print Med 2020 Feb 18;6(1). Epub 2020 Feb 18.

Department of Radiology, University of Cincinnati Medical Center, 234 Goodman Street, Cincinnati, OH, 45267, USA.

Background: Breast cancer is the most commonly diagnosed malignancy in females and frequently requires core needle biopsy (CNB) to guide management. Adequate training resources for CNB suffer tremendous limitations in reusability, accurate simulation of breast tissue, and cost. The relatively recent advent of 3D printing offers an alternative for the development of breast phantoms for training purposes. Read More

Clin Imaging 2020 Mar 12;60(1):100-108. Epub 2019 Dec 12.

The University of Texas MD Anderson Cancer Center, Department of Breast Imaging, 1155 Pressler, Unit 1350, CPB 5.3208, Houston, TX 77030, USA.

In patients with nonpalpable early-stage breast cancer eligible for breast conservation surgery (BCS), wire-guided localization (WGL) is widely accepted as a standard technique for preoperative image-guided lesion localization. In preparation for this procedure, lesion location, size, type and configuration play important roles in preoperative localization planning. Successful preoperative planning requires review of all pertinent imaging studies, imaging reports and pathology reports, with special attention to pre- and post-biopsy imaging and evaluation of the targeted lesions and the type and the position of the marker clips. Read More

J Pak Med Assoc 2019 Oct;69(10):1501-1504

Department of Clinical pathology, INMOL Hospital, Lahore, Pakistan.

Objective: To determine the outcome of sonographically-guided indigenous low-cost metallic clip placement for tumour localisation in patients of early breast cancer undergoing neoadjuvant chemotherapy. .

Methods: The prospective analytical study was conducted at the Institute of Nuclear Medicine and Oncology, Lahore, Pakistan, from May 2016 to December 2017, and comprised biopsy-proven breast cancer cases. Read More

AJNR Am J Neuroradiol 2019 11 3;40(11):1960-1964. Epub 2019 Oct 3.

From the Section of Neuroradiology (T.H.V., M.K., S.A., M.G.-M., M.M.C., J.M.D., B.E.-M.).

The use of transoral sonography-guided fine-needle aspiration for intraoperative localization of retropharyngeal masses has been described by Fornage et al. The purpose of this study was to assess the accuracy of this technique. We reviewed the images and medical records of 26 patients with a retropharyngeal lesion suspicious for a metastatic lymph node of Rouviere identified on CT and/or PET/CT. Read More

Breast 2019 Oct 23;47:93-101. Epub 2019 Jul 23.

Breast Surgery Unit, Comprehensive Cancer Center, University of Helsinki, Helsinki University Hospital Finland, P.O. Box 263, 00029, HUS, Finland.

Objectives: The aim of this retrospective study is to compare surgical margins, reoperation rates and local recurrences after breast conserving surgery (BCS) using radioguided occult lesion localization (ROLL) or radioactive seed localization (RSL).

Materials And Methods: We reviewed 744 consecutive patients with impalpable primary invasive breast cancer who underwent BCS at Helsinki University Hospital between 2010 and 2012. ROLL was used in our unit until October 31st, 2011; from November 1st we changed localization method to RSL. Read More

Perm J 2019 14;23. Epub 2019 Jun 14.

Department of Surgery, Oakland Medical Center, CA.

Context: Preoperative wire localization (WL), the most common localization technique for nonpalpable breast lesions, has drawbacks including scheduling constraints, cost, and patient discomfort.

Objective: To reduce WL use in our health care system, we investigated using hydrogel clips to facilitate intraoperative ultrasonography-guided lumpectomies.

Design: We retrospectively reviewed electronic medical records of patients with nonpalpable, ultrasound-visible breast lesions who underwent lumpectomy by 7 surgeons at 4 pilot sites in Kaiser Permanente Northern California between January 2015 and October 2015. Read More

World J Surg Oncol 2019 May 27;17(1):88. Epub 2019 May 27.

Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

Background: To retrospectively analyze perilesional technetium Tc-99m MAA injection for intraoperative localization of atypical soft-tissue and bone lesions within a single tertiary referral center in order to determine technique, safety, and clinical utility of these procedures.

Methods: An IRB compliant, retrospective electronic chart review (2010-2017) exploring surgical excision of atypical (non-pulmonary, non-breast, non-sentinel node) lesions guided by Tc-99m MAA perilesional injection. Patient demographics, lesion location, lesion size, radiotracer injection technique, radiotracer injection complications, scintigraphy technique, scintigraphic quality, intraoperative time, lesion identification in surgery, and pathological diagnoses were recorded. Read More

Ultrasonography 2019 Jul 8;38(3):272-276. Epub 2019 Jan 8.

Department of Pathology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.

Purpose: Absorbable retaining thread (ART) needle localization utilizes a guiding needle with a thread; this technique was invented to reduce patient discomfort and wire migration. We investigated the feasibility of ultrasound (US)-guided ART needle localization for nonpalpable breast lesions.

Methods: ART needle localization was performed for 26 nonpalpable breast lesions in 26 patients who were scheduled to undergo surgical excision the day after localization. Read More

Ginekol Pol 2019 ;90(3):122-127

University Center for Breast Diseases, University Hospital in Cracow, Poland.

Objectives: The aims of the study were as follows: 1) to determine the applicability of vacuum-assisted core needle biopsy in the diagnosis and management of intraductal papillomas of the breast; 2) to define factors which increase the risk for underestimation of breast cancer.

Material And Methods: Between 2002-2017, a total of 222 cases of intraductal papillomas were diagnosed in one center (201 using vacuum-assisted core-needle ultrasound-guided biopsy and 21 using stereotactic biopsy). All patients under- went scheduled follow-up imaging. Read More

Breast J 2019 05 28;25(3):479-483. Epub 2019 Mar 28.

Department of Radiology, UT MD Anderson Cancer Center, Houston, Texas.

We describe the history of, indications for, and techniques involved in MRI-guided needle localization (MRI-NL). MRI-NL continues to be a safe, effective method of sampling lesions that are only detected with MRI, particularly for anatomically challenging lesions such as those near the chest wall, the nipple, the skin, and/or in close proximity to implants. Read More

J Xray Sci Technol 2019 ;27(3):493-502

Department of Imaging Diagnosis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: To retrospectively explore correlation of the resected specimen volume of breast microcalcification lesions and endogenous and exogenous factors of stereotactic needle localization biopsy (SNLB).

Materials And Methods: Totally 214 patients underwent SNLB for non-palpable breast lesion with microcalcification lesions. Of 211 patients, 198 patients underwent single needle localization and 13 patients underwent multi-needle localization (26 lesions). Read More

Int J Surg Case Rep 2019 14;56:37-39. Epub 2019 Feb 14.

Department of Surgical Oncologists, Salah-Azaiez Institute, Boulevard of 9-Avril, 1001 Tunis, Tunisia.

Introduction: Chondrosarcoma (CS) was the third most common primary bone malignancy. Frequently chondrosarcoma was occurring in long bones or in the pelvis. Their localization in the rib is rare. Read More

AJR Am J Roentgenol 2019 04 23;212(4):943-946. Epub 2019 Jan 23.

1 Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Objective: The purpose of this study is to review tomosynthesis-guided wire and seed needle localizations of the breast and axilla performed at our institution.

Conclusion: Tomosynthesis-guided needle localizations were performed for 38 lesions, including 14 architectural distortions, five groups of calcifications, two focal asymmetries, three masses, four breast clips, and 10 axillary clips. All lesions were successfully removed at surgery, indicating that breast and axillary lesions can be precisely localized under tomosynthesis. Read More

Acta Radiol Open 2018 Dec 6;7(12):2058460118815726. Epub 2018 Dec 6.

Department of Gynecology, Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil.

Background: Image-guided charcoal injection in suspicious breast lesions for preoperative localization is a procedure that has been increasing over the years because it is safer, faster, and more affordable when compared to needle-wire preoperative localization. To date, no complications have been associated with the method. However, in recent years there have been some reports about charcoal granulomas mimicking malignant lesions in some postoperative patients or in a conservative follow-up. Read More

Ann Surg Oncol 2018 Nov 3;25(12):3740-3746. Epub 2018 Sep 3.

Department of Surgery, University of California San Diego, San Diego, CA, USA.

Background: Preoperative breast and lung markers have significant drawbacks, including migration, patient discomfort, and scheduling difficulties. SignalMark is a novel localizer device with a unique signal on Doppler ultrasound.

Objective: We aimed to evaluate intraoperative identification of SignalMark microspheres compared with HydroMARK clips. Read More

Ann Surg Oncol 2018 Oct 15;25(10):3076-3081. Epub 2018 Aug 15.

Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Localization of nonpalpable breast lesions for breast-conserving surgery (BCS) remains highly variable and includes needle/wire localization (NL), radioactive seed localization, radar localization, and hematoma-directed ultrasound-guided (HUG) lumpectomy. The superiority of HUG lumpectomy over NL has been demonstrated repeatedly in terms of safety, accuracy, low positive margin rates, cosmesis, and patient satisfaction. In this study, we evaluate the cost effectiveness of HUG lumpectomy over NL for nonpalpable breast lesions. Read More

AJR Am J Roentgenol 2018 10 7;211(4):940-945. Epub 2018 Aug 7.

1 Department of Radiology, Massachusetts General Hospital, 55 Fruit St, WAC 240, Boston, MA 02114.

Objective: The purpose of this study is to evaluate the feasibility and effectiveness of a nonradioactive magnetic marker wireless localization technique.

Materials And Methods: A retrospective review was performed of consecutive patients who underwent image-guided needle localization with nonradioactive magnetic markers and subsequent surgical excision from March to August 2017. Indications for marker placement, lesion type, imaging guidance used for marker placement, postprocedure mammographic imaging and reports, surgical reports, and surgical margin status were reviewed. Read More

Eur J Surg Oncol 2018 09 9;44(9):1307-1311. Epub 2018 Jun 9.

University of Rostock, Department of Obstetrics and Gynecology, Südring 81, 18059, Rostock, Germany.

Introduction: Clipping and selective removal of initially suspicious axillary lymph nodes in breast cancer patients who have been sonographically down-staged by primary systemic therapy improves the accuracy of surgical staging and provides the opportunity for more conservative axillary surgery. This study evaluated whether preoperative ultrasound-guided wire localization of the clipped node is useful for routine clinical practice.

Material And Methods: This prospective, single-center feasibility trial included patients with invasive breast cancer (cT1-3N1-3M0) treated by primary systemic therapy. Read More

Otolaryngol Head Neck Surg 2018 08 24;159(2):394-397. Epub 2018 Apr 24.

2 Department of Head and Neck Surgery, Miami Cancer Institute, Miami, Florida, USA.

Intraoperative localization of nonpalpable recurrent thyroid cancer has been reported using needle localization, intraoperative ultrasound (US), dye injection, and radio-guided surgery. We describe the alternative technique of radioactive seed localization (RSL) in 3 patients with residual or recurrent papillary thyroid cancer. This technique has been used for many years in the setting of nonpalpable breast cancer, where it has been shown to be safe and has been associated with greater surgeon satisfaction as well as improved patient tolerability, cosmesis, and outcomes compared to needle localization. Read More

Magn Reson Imaging Clin N Am 2018 May 21;26(2):235-246. Epub 2018 Feb 21.

Department of Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1350, Houston, TX 77030, USA.

MR imaging is now routinely performed for breast cancer screening and staging. For suspicious MR imaging-detected lesions that are mammographically and sonographically occult, MR imaging-guided breast interventions, including biopsy, clip placement, and preoperative needle localization, have been developed to permit accurate tissue diagnosis and aid in surgical planning. These procedures are safe, accurate, and effective when performed according to key principles, including proper patient selection, use of appropriate technique, adequate preprocedure preparation and postprocedure patient care, and postprocedure imaging-pathology correlation. Read More

Asian Pac J Cancer Prev 2018 Mar 27;19(3):763-767. Epub 2018 Mar 27.

Departments of Diagnostic Radiology and Medicine, Aga Khan University Hospital, Karachi, Pakistan. Email:

Objective: The aim of this study was to evaluate the accuracy of “X- ray examination of surgically resected specimen‘‘ in assessing complete local excision (CLE). Materials and Methods: In this retrospective cross sectional study, data were collected for all female breast cancer cases who underwent breast-conserving surgery after needle localization of mammographically visible disease. Males, patients with mammographically invisible disease and cases with benign or inconclusive histopathology, those undergoing modified radical mastectomy and individuals with dense breast parenchyma were excluded. Read More

Breast Cancer 2018 Sep 23;25(5):575-582. Epub 2018 Mar 23.

Breast Center, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan.

Purpose: To evaluate the usefulness of the HydroMARK, a hydrogel-based breast biopsy site marker for ultrasound localization of breast lesions, we investigated the tendency for dislocation and sonographic detectability of the marker placed in patients.

Materials And Methods: The marker was placed in lesions that were expected to become obscured after biopsy for a suspicious breast lesion or after neoadjuvant chemotherapy for breast cancer. The patients consented to return for a repeat ultrasound ± mammography examination, and the degree of displacement of the marker was measured as the marker-to-residual lesion distance. Read More

Can Assoc Radiol J 2018 Feb;69(1):10-15

Breast Health Program, BC Women's Hospital and Health Centre, Vancouver, Canada; Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

Purpose: The placement of localization clips following percutaneous biopsy is a standard practice for a variety of situations. Subsequent clip displacement creates challenges for imaging surveillance and surgical planning, and may cause confusion amongst radiologists and between surgeons and radiologists. Many causes have been attributed for this phenomenon including the commonly accepted "accordion effect. Read More

Pediatr Radiol 2018 05 23;48(5):626-631. Epub 2018 Jan 23.

Department of Radiology, Division of Interventional Radiology, Texas Children's Hospital, Houston, TX, USA.

Background: Pulmonary nodules in pediatric oncology patients can present a diagnostic and treatment dilemma. Imaging findings are often nonspecific and tissue diagnosis may be required for appropriate treatment. The smaller subpleural nodules may not be visualized and cannot be palpated during video-assisted thoracoscopic surgical (VATS) resection. Read More

J Coll Physicians Surg Pak 2017 Dec;27(12):747-750

Department of Radiology, The Aga Khan University Hospital, Karachi.

Objective: To evaluate the success of ultrasound in post-excision specimen visualization, and negative predictive value of ultrasound for estimation of tumor-free margins using histopathology as the gold standard.

Study Design: Cross-sectional analytical study.

Place And Duration Of Study: The Aga Khan University Hospital, Karachi, Pakistan, from May 2010 till January 2013. Read More

Acta Biomater 2018 Jan 19;65:197-202. Epub 2017 Oct 19.

Center for Nanomedicine and Theranostics, Department of Chemistry, Technical University of Denmark, Building 207, Kemitorvet, 2800 Kgs. Lyngby, Denmark. Electronic address:

We have developed a I-radiolabeled injectable fiducial tissue marker with the potential to replace current methods used for surgical guidance of non-palpable breast tumors. Methods in routine clinical use today such as radioactive seed localization, radio-guided occult lesion localization and wire-guided localization suffers from limitations that this injectable fiducial tissue marker offers solutions to. The developed I-radiolabeled injectable fiducial tissue marker is based on highly viscous sucrose acetate isobutyrate. Read More

Anticancer Res 2017 08;37(8):4523-4527

Cardiff China Medical Research Collaborative, Cardiff University, School of Medicine, Cardiff, U.K.

Aim: To evaluate the usefulness of localization needles under mammographic, ultrasound or fiberoptic ductoscopy guidance for non-palpable breast lesions.

Patients And Methods: Eighty-three patients undergoing needle localization and biopsy of non-palpable breast lesions under mammographic, ultrasound or fiberoptic ductoscopy guidance from June 2013 to December 2014 in Beijing Friendship Hospital were included in the study. The preoperative imaging assessment, application of localization needles, surgical operation and pathological examination were recorded and analyzed retrospectively. Read More

Radiol Med 2017 Oct 25;122(10):723-730. Epub 2017 May 25.

Unit of Radiology, IRCCS Policlinico San Donato, Via Morandi 30, San Donato Milanese, 20097, Milan, Italy.

This position paper, issued by ICBR/SIRM and GISMa, summarizes the evidence on DBT and provides recommendations for its use. In the screening setting, DBT in adjunct to digital mammography (DM) increased detection rate by 0.5-2. Read More

Radiology 2017 09 26;284(3):645-655. Epub 2017 Apr 26.

From the Department of Diagnostic and Interventional Radiology (C.K.K., K.S., S.S.), Section of Bioinformatics, Department of Diagnostic and Interventional Radiology (H.B.), and Department of Gynecology and Gynecologic Oncology (N.M.), University of Aachen, RWTH, Pauwelsstr 30, 52074 Aachen, Germany; Department of Pathology, University of Muenster, Muenster, Germany (E.W.); and Department of Gynecology, University of Bonn, Bonn, Germany (W.K.).

Purpose To (a) compare the diagnostic accuracy of breast magnetic resonance (MR) imaging with that of conventional imaging (digital mammography and breast ultrasonography) in the identification of ductal carcinoma in situ (DCIS) components of biopsy-proven invasive breast cancer before surgery and (b) investigate the surgical outcome (positive margin rates and mastectomy rates) of women with breast cancer who underwent preoperative MR imaging combined with MR-guided needle biopsy and/or MR-guided lesion localization or bracketing where appropriate. Materials and Methods The authors performed a prospective two-center study of 593 consecutive patients with biopsy-proven invasive breast cancer who underwent breast MR imaging in addition to conventional imaging. MR-guided vacuum biopsy and MR-guided lesion bracketing were performed for DCIS components visible at MR imaging alone. Read More

AJR Am J Roentgenol 2017 Dec 5;209(6):1367-1373. Epub 2017 Apr 5.

1 Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.

Objective: The purpose of this study is to evaluate a new device using molecular breast imaging (MBI) for Tc-sestamibi-guided stereotactic lesion localization as a complementary biopsy tool.

Materials And Methods: From December 2012 to May 2016, a total of 38 consecutive women (mean age, 59 years; range, 41-77 years) underwent Tc-sestamibi-guided biopsy using a new MBI-based device and were retrospectively reviewed. The biopsy modality used five steps: stereotactic localization of the Tc-sestamibi-avid lesion, calculation of coordinates of the lesion location using dedicated software, placement of the needle, verification of the correct needle position, and tissue sampling with a vacuum-assisted device followed by placement of a radiologic marker at the biopsy site and ex vivo measurement of the biopsy specimens. Read More

Geburtshilfe Frauenheilkd 2017 Feb;77(2):169-175

Universitätsfrauenklinik Erlangen, Universitätsklinikum Erlangen, Erlangen.

The placement of intramammary marker clips has proven to be helpful for tumor localization in patients undergoing neoadjuvant chemotherapy and breast-conserving surgery. The purpose of our study was to investigate the feasibility of using a clip marker system for breast cancer localization and its influence on the imaging assessment of treatment responses after neoadjuvant chemotherapy. Between March and June 2015, a total of 25 patients (n = 25), with a suspicion of invasive breast cancer with diameters of at least 2 cm (cT2), underwent preoperative sonographically guided core needle biopsy using a single-use breast biopsy system (HistoCore™) and intramammary clip marking using a directly adapted clip system based on the established O-Twist Marker™, before their scheduled preoperative neoadjuvant chemotherapy. Read More

Skeletal Radiol 2017 Jul 9;46(7):975-981. Epub 2017 Mar 9.

Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA, 02215, USA.

MRI-guided wire localization is commonly used for surgical localization of breast lesions. Here we introduce an alternative use of this technique to help with surgical resection of a recurrent pleomorphic sarcoma embedded in extensive post-treatment scar tissue. We describe a case of recurrent pleomorphic soft tissue sarcoma in the thigh after treatment with neoadjuvant therapy, surgery, and radiation. Read More

AJR Am J Roentgenol 2017 Jun 7;208(6):1400-1409. Epub 2017 Mar 7.

3 Department of Pathology, Marmara University School of Medicine, Istanbul, Turkey.

Objective: The purpose of this study is to assess the utility of a volume navigation technique (VNT) for ultrasound-guided biopsy of MRI-detected, but sonographically ambiguous or occult, breast lesions.

Subjects And Methods: Within a recruitment period of 13 months (January 1, 2014, through February 1, 2015), 22 patients with 26 BI-RADS category 4 or 5 lesions that were detected at MRI but missed at second-look ultrasound were reimaged using a rapid sequence and a flexible body coil in a 3-T MRI scanner. Patients were supine, with three skin markers placed on the breasts. Read More

Int J Comput Assist Radiol Surg 2017 Aug 6;12(8):1319-1331. Epub 2017 Feb 6.

Department of Biomedical Engineering, National Cancer Center, 323 Ilsanro, Ilsandong-gu, Goyang-si, 10408, Gyeonggi-do, Republic of Korea.

Purpose: We developed an image-guided intervention robot system that can be operated in a magnetic resonance (MR) imaging gantry. The system incorporates a bendable needle intervention robot for breast cancer patients that overcomes the space limitations of the MR gantry.

Methods: Most breast coil designs for breast MR imaging have side openings to allow manual localization. Read More

Acta Cytol 2017 22;61(1):47-54. Epub 2016 Dec 22.

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Background: Cutaneous metastases can occur in a wide variety of internal malignancies and may be the first sign of a clinically silent visceral cancer.

Study Design: A retrospective analysis was made of 138 cases diagnosed with cutaneous and subcutaneous metastasis on fine-needle aspiration cytology (FNAC). Primary tumors of the skin/subcutis were excluded. Read More

Clin Breast Cancer 2017 02 19;17(1):18-22. Epub 2016 Oct 19.

Florida Hospital - N Pinellas, University of South Florida, Morsani College of Medicine, Tampa, FL. Electronic address:

Introduction: With the advent and proliferation of breast cancer screening programs, more women are being diagnosed with mammographic abnormalities that require tissue diagnosis. If imaged-guided biopsy is not possible or previous image-guided biopsies reveal pathologies that require more extensive surgery, guided excisional biopsy/lumpectomy may be necessary.

Methods: Fifteen women were enrolled in the study of the feasibility of off-site or day-before wire-localization excisional biopsy of the breast with mammographic abnormalities. Read More

Breast Cancer 2017 Jul 12;24(4):585-592. Epub 2016 Nov 12.

Breast Center, Kameda Medical Center, 929 Higashi-cho, Kamogawa, Chiba, 296-8602, Japan.

Purpose: To evaluate the usefulness of the UltraClip dual trigger breast tissue marker (UltraClip) for sonographic localization, we investigate the sonographic visibility and sonographic appearance of the UltraClip placed in phantoms and patients.

Materials And Methods: Ten UltraClips were placed in the target lesions in the phantoms. After the ultrasound examination of the UltraClip, the ultrasound images were compared to the real appearance of the UltraClip obtained by cutting the phantoms. Read More

Am J Surg 2017 Apr 20;213(4):798-804. Epub 2016 Oct 20.

Department of Surgery, McMaster University, St. Joseph's Healthcare, Hamilton, ON, Canada. Electronic address:

Background: This study compared 5-year breast cancer (BC) recurrence rates in patients randomized to radioguided seed localization (RSL) or wire localization (WL) for non-palpable BC undergoing breast conserving surgery.

Methods: Chart review of follow-up visits and surveillance imaging was conducted. Data collected included patient and tumour factors, adjuvant therapies and BC recurrence (local recurrence (LR), regional recurrence (RR), and distant metastasis (DM)). Read More

Eur J Nucl Med Mol Imaging 2017 Apr 27;44(4):630-637. Epub 2016 Oct 27.

Department of Nuclear Medicine, The Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Background: In recent years repeat sentinel node (SN) biopsy has been proven to be feasible in local breast cancer recurrence (LBCR). However, in these patients SNs outside the ipsilateral axilla are frequently observed. This study evaluates the contribution of SPECT/CT for SN localization and surgical adjustment in LBCR patients. Read More

J Minim Invasive Gynecol 2017 01 30;24(1):171-173. Epub 2016 Sep 30.

Sanchinarro University Hospital, Madrid, Spain.

The radio-guided occult lesion localization (ROLL) technique has been in use since the mid-1990s, mainly in breast surgery. Today, ROLL is used for numerous oncologic pathologies, including parathyroid lesions, melanomas, and colorectal tumors. We report a patient with an 11-mm left mesorectal solitary recurrence of a primary ovarian cancer in whom the ROLL technique was used to identify the implant. Read More

PLoS One 2016 1;11(7):e0157854. Epub 2016 Jul 1.

School of Engineering Science, University of Science and Technology of China, Hefei, China.

Surgical resection remains the primary curative treatment for many early-stage cancers, including breast cancer. The development of intraoperative guidance systems for identifying all sites of disease and improving the likelihood of complete surgical resection is an area of active ongoing research, as this can lead to a decrease in the need of subsequent additional surgical procedures. We develop a wearable goggle navigation system for dual-mode optical and ultrasound imaging of suspicious lesions. Read More

AJR Am J Roentgenol 2016 Sep 8;207(3):676-84. Epub 2016 Jun 8.

1 Department of Radiology, New York University Langone Medical Center, 160 E 34th St, New York, NY 10016.

Objective: MRI-guided needle localization allows access to MRI-detected mammographically occult breast lesions that are not amenable to MRI-guided biopsy. The purpose of this study was to examine the safety and outcomes of MRI-guided needle localization.

Materials And Methods: Ninety-nine consecutive breast lesions that underwent preoperative MRI-guided needle localization were identified. Read More

Ann Surg 2017 05;265(5):987-992

*Departments of Surgery, University of Arkansas for Medical Sciences, Winthrop P. Rockefeller Institute, Little Rock, AR †Departments of Pathology, University of Arkansas for Medical Sciences, Winthrop P. Rockefeller Institute, Little Rock, AR ‡Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR.

Background: We hypothesized that disconcerting lymphedema rates in both sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) may be because of unrecognized vunerable variations in arm lymphatic drainage within the axilla. Axillary reverse mapping (ARM) facilitates identification and avoidance of arm lymphatics within the axilla and its use may reduce lymphedema.

Methods: This institutional review board-approved study from June 2007 to December 2013 involved patients undergoing SLNB with or without ALND, or ALND alone. Read More

Eur J Radiol 2016 Jun 16;85(6):1157-66. Epub 2016 Mar 16.

Dept. of Diagnostical and Interventional Radiology, University Hospital of Cologne, Germany.

Purpose: The study was conducted in order to assess the clinical impact of MRI-guided vacuum-assisted breast biopsies carried out using an open 1.0T open MRI-system.

Material And Methods: The clinical, imaging, interventional and histological data of all 132 patients with a first MRI-guided vacuum-assisted breast biopsy carried out between 07/2005 and 03/2012at the Radiological Department were extracted from the clinical files. Read More

Radiographics 2016 Mar-Apr;36(2):311-21

From the Department of Radiology, Yale University School of Medicine, 333 Cedar St, PO Box 208042, New Haven, CT 06520-8042 (M.A.D., R.J.H., M.R., L.E.P.); and Department of Radiology, Kaiser Permanente, Bakersfield, Calif (S.W.).

As use of digital breast tomosynthesis becomes increasingly widespread, new management challenges are inevitable because tomosynthesis may reveal suspicious lesions not visible at conventional two-dimensional (2D) full-field digital mammography. Architectural distortion is a mammographic finding associated with a high positive predictive value for malignancy. It is detected more frequently at tomosynthesis than at 2D digital mammography and may even be occult at conventional 2D imaging. Read More

Plast Reconstr Surg 2016 Mar;137(3):792-8

Rome, Italy From the Department of Plastic, Reconstructive and Aesthetic Surgery and the Center for Integrated Biomedical Research, Laboratory of Microscopic and Ultrastructural Anatomy, "Campus Bio-Medico di Roma" University.

Background: Capsular contracture is the most common complication following breast augmentation and reconstruction. Myofibroblasts, which are specialized fibroblasts with contractile activity, are involved in its pathogenesis. Toll-like receptor 4 stimulation in fibroblasts induces transcription of genes involved in extracellular matrix remodeling and tissue repair; furthermore, it enhances sensitivity to transforming growth factor-β1 and promotes transition to myofibroblasts. Read More

PLoS One 2016 11;11(2):e0149018. Epub 2016 Feb 11.

Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.

Background: To evaluate whether tumor localization and method of preoperative biopsy affect sentinel lymph node (SLN) detection after periareolar nuclide injection in breast cancer patients.

Methods And Findings: 767 breast cancer patients were retrospectively included. For lymphscintigraphy periareolar nuclide injection was performed and the SLN was located by gamma camera. Read More