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Am Surg 2022 Jun 27:31348221111516. Epub 2022 Jun 27.

Department of General Surgery, 6529Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Background: Bracketed localization is a technique used to help localize lesions for breast-conserving surgery (BCS). To date, there are no guidelines for when bracketed localization should be used in clinical practice. Based on our experience, we aim to provide criteria that should prompt surgeons to consider bracketing. Read More

Am Soc Clin Oncol Educ Book 2022 Apr;42:1-9

Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA.

The increasing use of neoadjuvant therapy has resulted in therapeutic decisions being made on the basis of diagnostic needle core biopsy. For many patients, this method might yield the only fragment of tumor available for biomarker analysis, necessitating judicious use. Many multiplex protein analytic methods have been developed that employ fluorescence or other tags to overcome the limitations of immunohistochemistry while still retaining the spatial annotation. Read More

Am Surg 2022 May 4:31348221096576. Epub 2022 May 4.

Department of Surgery, 23436MedStar Union Memorial and Good Samaritan Hospitals, Baltimore, MD, USA.

Background: The standard localization of non-palpable breast masses is wire/needle localization (WL). Newer technologies have evolved, allowing more efficient scheduling and improving surgeon and patient experiences. These include Radioactive Seed, MagSeed®, and SAVI Scout® (SS). Read More

Plast Reconstr Surg Glob Open 2022 Apr 25;10(4):e4286. Epub 2022 Apr 25.

Division of Plastic and Reconstructive Surgery, Fox Chase Cancer Center, Philadelphia, Pa.

Outcomes related to the treatment of breast implant-associated anaplastic large cell lymphoma, a rare extranodal T-cell lymphoma associated with textured breast implants, are largely dependent on the successful resection to negative margins via en bloc capsulectomy and resection of any associated masses. To date, the use of needle localization, a common technique used in breast surgery, to assist in the complete removal of breast implant-associated anaplastic large cell lymphoma has not been described. We present the case report of a 66-year-old woman, with a previous medical history of left-sided invasive ductal carcinoma, who presented 7 years after textured breast implant placement with a left-sided mass without peri-implant seroma. Read More

Eur J Breast Health 2022 Apr 1;18(2):190-194. Epub 2022 Apr 1.

Department of Radiology, Ege University Faculty of Medicine, İzmir, Turkey.

Vascular tumors are rare in the breasts, and the most common forms include hemangiomas and angiosarcomas. Hemangiomas are rare benign vascular tumors. Most of them are asymptomatic and nonpalpable clinically, and the vast majority of such lesions are detected incidentally by mammography. Read More

Diagn Cytopathol 2022 Feb 27;50(2):75-83. Epub 2021 Dec 27.

Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden.

Background: Descriptions of parathyroid cell cyto-morphology are limited. Fine-needle aspiration cytology (FNAC) with immunocytochemistry (ICC) or biochemical PTH measurements may help verify the parathyroid origin in extraordinary cases, although these methods are nowadays largely replaced by imaging techniques.

Methods: We collected all available FNAC reports of parathyroid lesions from our department spanning 20 years, to characterize the clinical use of parathyroid FNAC, and to assess morphological correlates between cytology and subsequent histopathology. Read More

Tech Vasc Interv Radiol 2021 Sep 2;24(3):100776. Epub 2021 Oct 2.

Department of Radiology and Imaging Sciences, University of Utah and Huntsman Cancer Institute, Salt Lake, City, UT. Electronic address:

Core needle biopsies are common procedures performed in breast imaging centers. Utilizing ultrasound guidance for biopsy of suspicious findings within the breast and axilla is the standard of care when lesions are visible on ultrasound. Most ultrasound guided breast biopsies are performed by radiologists interpreting breast imaging who correlate findings across modalities including mammography, ultrasound and breast MRI, however interventional radiologists may perform in some practice settings. Read More

Indian J Radiol Imaging 2021 Apr 28;31(2):391-399. Epub 2021 Jul 28.

Department of Radiodiagnosis, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India.

Breast interventions primarily comprise of biopsy of the suspicious breast lesions to obtain accurate pathological diagnosis. Generally, image-guided breast biopsy is required for nonpalpable lesions, however, even in palpable lesions, image-guided biopsy should be performed as it improves the accuracy of diagnosis. Image-guided breast interventions have progressed well beyond biopsy, making the radiologist an important part of the multidisciplinary management of breast cancer. Read More

Tzu Chi Med J 2021 Jul-Sep;33(3):275-281. Epub 2021 Mar 22.

Division of General Surgery, Department of Surgery, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei, Taiwan.

Objective: The current study aimed to retrospectively assess the cancer detection rate of needle localization biopsy of breast microcalcifications undetectable on sonography.

Materials And Methods: Patients who underwent mammography-guided needle localization biopsy of breast microcalcifications undetectable on sonography from January 2005 to December 2017 were included in the study. Patients with incomplete medical records were excluded from the study. Read More

J Cutan Pathol 2021 Nov 16;48(11):1387-1391. Epub 2021 Jun 16.

Department of Breast Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

Syringocystadenocarcinoma papilliferum (SCACP) is a rare cutaneous adnexal tumor thought to originate from its benign counterpart, syringocystadenoma papilliferum. These tumors are predominantly located on the head and neck with their location on the breast extraordinarily reported; mammary localization poses a great diagnostic dilemma to the practicing pathologist. Herein, we report an unusual case of an 85-year-old woman with an outside diagnosis on a core needle biopsy of metaplastic mammary carcinoma. Read More

Expert Rev Med Devices 2021 May 29;18(5):413-420. Epub 2021 Apr 29.

Division of Surgical Oncology, Department of Surgery, The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, OH, USA.

: Percutaneous image-guided biopsy is the procedure of choice for diagnosing suspicious abnormalities on breast imaging. Stereotactic, ultrasound, and magnetic resonance imaging are used for image-guided breast biopsies. Stereotactic guidance uses mammography to localize lesions and facilitate placement of a core biopsy needle. Read More

Tumori 2021 Dec 24;107(6):NP59-NP62. Epub 2021 Mar 24.

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Background: Although most breast masses in children are benign, breast cancer must be considered in the differential diagnosis. The majority are represented by sarcomas and secondary lesions. Literature reports only four cases of neuroblastoma breast metastasis, with no emphasis on radiologic features. Read More

Adv Clin Exp Med 2021 Mar;30(3):273-278

Breast Unit, Division of Breast Surgery, Lower Silesian Oncology Center, Wrocław, Poland.

Background: The Sentimag hand-held probe detects the magnetic response from iron oxide particles trapped in a sentinel node.

Objectives: To investigate if an electromagnetic probe can be helpful in the identification of a hook wire tip located in an occult breast lesion.

Material And Methods: Forty-two patients undergoing lumpectomy without axillary procedure were enrolled. Read More

Ann Surg Oncol 2021 Sep 6;28(9):4974-4980. Epub 2021 Mar 6.

Department of Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Needle localization of a marking clip is required to guide accurate removal of many breast lesions. When the clip is not visualized on specimen radiography, concerns regarding the completeness of cancer removal and long-term outcomes arise. Using a large cohort of women undergoing breast conservation, we examined the magnitude of the problem and the outcome of women with a missing clip. Read More

Ultrasound Obstet Gynecol 2021 Nov 6;58(5):766-772. Epub 2021 Oct 6.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.

Objective: To evaluate the feasibility and clinical application of fusion imaging with virtual navigation, combining F-fluorodeoxyglucose ( F-FDG) positron emission tomography/computed tomography (PET/CT) with real-time ultrasound imaging, in assessing superficial lymph nodes in breast-cancer and gynecological-cancer patients.

Methods: This was a pilot study of breast- and gynecological-cancer patients with abnormal uptake of F-FDG by axillary or groin lymph nodes on PET/CT scan, examined at our institution between January 2017 and May 2019. Fusion imaging was performed, uploading preacquired PET/CT DICOM images onto the ultrasound machine and synchronizing them with real-time ultrasound scanning performed at the lymph-node site. Read More

Med Phys 2021 Apr 2;48(4):1859-1873. Epub 2021 Mar 2.

Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, N6A 3K7, Canada.

Purpose: Image-guided needle biopsy of small, detectable lesions is crucial for early-stage diagnosis, treatment planning, and management of breast cancer. High-resolution positron emission mammography (PEM) is a dedicated functional imaging modality that can detect breast cancer independent of breast tissue density, but anatomical context and real-time needle visualization are not yet available to guide biopsy. We propose a mechatronic guidance system integrating an ultrasound (US)-guided core-needle biopsy (CNB) with high-resolution PEM localization to improve the spatial sampling of breast lesions. Read More

Breast J 2021 04 22;27(4):403-405. Epub 2021 Jan 22.

First Department of Propaedeutic Surgery, Medical School, "Hippocratio" General Hospital, University of Athens, Athens, Greece.

Preoperative hook localization is a necessary procedure for targeting impalpable breast lesions. The aim of the current study is to introduce an alternative technique of wire placement by using the stereotactic biopsy device instead of the conventionally used mammography device. Fifty-one patients with impalpable mammographic lesions, graded BIRADS 4 or 5, were prospectively enrolled. Read More

Med Phys 2021 Mar 8;48(3):1299-1306. Epub 2021 Feb 8.

Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA.

Purpose: To develop a scheme to quantitatively assess localization accuracy of tomosynthesis-guided vacuum-assisted breast biopsy apparatus.

Methods: A phantom containing a metallic pellet on a flexible plastic shaft was constructed and was tested in cranio-caudal (CC) and lateral (LAT) arm biopsy geometries following the standard clinical breast biopsy workflow. Three points were manually digitized on tomosynthesis images including: the center of the target, and the tip of the needle in pre- and postfire positions. Read More

Radiologe 2021 Feb 11;61(2):159-165. Epub 2021 Jan 11.

Abteilung für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Tübingen, Tübingen, Deutschland.

Background: Interventional methods of the breast serve as percutaneous minimally invasive diagnostic tools in case of suspicious findings in the breast or axilla. Further indications are lesion localization and the minimally invasive therapeutic approach.

Objectives: Aim of this paper is to give an overview of the existing methods, their indications and the imaging techniques for guidance. Read More

Cancers (Basel) 2020 Nov 30;12(12). Epub 2020 Nov 30.

Neoplasia & Endocrine Differentiation P0L5, Centro de Investigación en Medicina Moleculary Enfermedades Crónicas (CIMUS), Instituto de Investigación Sanitaria (IDIS), University of Santiago de Compostela (USC), 15782 Santiago de Compostela, Spain.

Multiplex immunohistochemistry (mIHC) use markers staining different cell populations applying widefield optical microscopy. Resolution is low not resolving subcellular co-localization. We sought to colocalize markers at subcellular level with antibodies validated for clinical diagnosis, including the single secondary antibody (combination of anti-rabbit/mouse-antibodies) used for diagnostic IHC with any primary antibody, and confocal microscopy. Read More

Int J Surg Case Rep 2020 31;77:325-328. Epub 2020 Oct 31.

Gynecology-Obstetrics and Endoscopy Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed V, Rabat, Morocco.

Introduction: The hydatid cyst of the breast is a rare pathology even in countries endemic to tuberculosis, however there remains a differential diagnosis evoked in front of any breast tumor. The clinic, mammography and ultrasound sometimes allow us to suspect the hydatid nature of the lesion. The definitive diagnosis remains histological and the treatment is always surgical. Read More

Ann Surg Oncol 2021 Jun 10;28(6):3223-3229. Epub 2020 Nov 10.

Department of Surgery, University Hospitals, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Background: As an alternative to traditional wire localization, an inducible magnetic seed system can be used to identify and remove nonpalpable breast lesions and axillary lymph nodes intraoperatively. We report the largest single-institution experience of magnetic seed placement for operative localization to date, including feasibility and short-term outcomes.

Methods: Patients who underwent placement of a magnetic seed in the breast or lymph node were identified from July 2017 to March 2019. Read More

Breast Cancer 2021 Mar 1;28(2):527-532. Epub 2020 Nov 1.

Department of Advanced Biomedical Sciences, University of Naples "Federico II", Via S. Pansini, 5, 80131, Naples, Italy.

We report a case of a 55-year-old woman with left breast cosmetic augmentation performed 5 years earlier, showing at ultrasound a left small amount of peri-implant effusion suspicious for an anaplastic large cell lymphoma localization. The final diagnosis was obtained by cytology using a small amount of fluid (6 ml). Subsequently, hybrid 18F-FDG PET/MRI was used for pre-operative staging and follow-up. Read More

Eur Radiol 2021 May 30;31(5):2645-2656. Epub 2020 Oct 30.

Radiology Unit, Department of Pathology and Diagnostics, Azienda Ospedaliera Universitaria Integrata - Verona, P.le Stefani 1, 37126, Verona, Italy.

Objectives: This study evaluated the feasibility of DWI for lesion targeting in MRI-guided breast biopsies. Furthermore, it assessed device positioning on DWI during biopsy procedures.

Methods: A total of 87 biopsy procedures (5/87 bilateral) consecutively performed between March 2019 and June 2020 were retrospectively reviewed: in these procedures, a preliminary DWI sequence (b = 1300 s/mm) was acquired to assess lesion detectability. Read More

AJR Am J Roentgenol 2021 09 21;217(3):605-612. Epub 2020 Oct 21.

Department of Radiology, Massachusetts General Hospital, 55 Fruit St, WAC 240, Boston, MA 02114.

Advantages of radiofrequency tags for preoperative breast lesion localization include decoupling of tag placement from surgical schedules and improved patient comfort. The purpose of this study was to evaluate the feasibility of a preoperative localization radiofrequency tag system for breast lesions requiring surgical excision. The cohort for this retrospective study included consecutive patients who underwent image-guided needle localization with radiofrequency tags before surgical excision from July 12, 2018, to July 31, 2019. Read More

Cancer Rep (Hoboken) 2021 02 7;4(1):e1300. Epub 2020 Oct 7.

Department of Anatomy, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Background: The pathophysiology of the breast phyllodes tumors is uncertain. Currently, wide surgical removal is the only available treatment option. The histopathological diagnosis of phyllodes tumors is often confused with that of fibroadenomas due to a striking histological resemblance. Read More

Br J Radiol 2020 Oct 24;93(1114):20200495. Epub 2020 Jul 24.

Department of Radiology, Mayo Clinic, Rochester, MN, United States.

As tomosynthesis is rapidly adopted by breast imaging practices, tomosynthesis-guided procedures are increasingly being performed. Tomosynthesis-guided needle localizations are feasible and efficient and allow for localization of tomosynthesis-only findings or one-view findings, which may be difficult to localize under standard digital mammography. In this review, we describe our step-by-step approach for performing tomosynthesis-guided localizations of the breast and axilla using a standard tomosynthesis unit. Read More

J Cancer 2020 20;11(16):4671-4682. Epub 2020 May 20.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.

With a high sensitivity of breast lesions, MRI can detect suspicious lesions which are occult in traditional breast examination equipment. However, the lower and variable specificity of MRI makes the MRI-guided intervention, including biopsies and localizations, necessary before surgery, especially for patients who need the treatment of breast-conserving surgery (BCS). MRI techniques and patient preparation should be first carefully considered before the intervention to avoid lengthening the procedure time and compromising targeting accuracy. Read More

Minerva Chir 2020 Aug 26;75(4):255-259. Epub 2020 May 26.

Department of Surgical Oncology, University of Perugia, Perugia, Italy.

Background: Non-palpable breast lesions are more frequent now than in the past due to the attention toward the mammary pathology and the screening diffusion; the marking of such lesions is very important for a successful surgery. The SentiMag System uses a magnetic marker that is inoculated transdermal in the breast through an 18-gauge needle.

Methods: Between April 1^st and June 30^th, 2018, 16 patients with non-palpable breast lesions were selected and subjected to surgery using the SentiMag System in our Unit. Read More

Folia Med (Plovdiv) 2020 03;62(1):23-30

Military Medical Academy, Sofia, Bulgaria.

Introduction: Although the liver and lung are the most frequently affected organs in cystic echinococcosis, the cysts may develop in any viscera and tissues. Breast is a rare primary localization with few cases described in the literature. We present an updated and systematic review and discuss the possible mechanisms of spreading, diagnostic and treatment options. Read More