524 results match your criteria Breast Benign Calcifications


Clinicopathologic update of calcium oxalate in breast: A 15-year retrospective review.

Breast J 2020 Jun 21. Epub 2020 Jun 21.

Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown University, Providence, RI, USA.

Mammary malignancies are radiologically detected by presence of masses, architectural distortions or microcalcifications. Unlike calcium hydroxyapatite, calcium oxalate (CaOx) deposits have been almost exclusively associated with benign mammary processes. The etiology and mechanism of mammary CaOx deposition remains poorly understood, and the original studies elucidating its histopathologic correlation are dated several decades ago. Read More

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http://dx.doi.org/10.1111/tbj.13952DOI Listing

Missed Breast Cancer: Effects of Subconscious Bias and Lesion Characteristics.

Radiographics 2020 Jul-Aug;40(4):941-960. Epub 2020 Jun 12.

From the Department of Radiology, Division of Breast Imaging, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Medical errors are a substantial cause of morbidity and mortality and the third leading cause of death in the United States. Errors resulting in missed breast cancer are the most common reason for medical malpractice lawsuits against all physicians. Missed breast cancers are breast malignancies that are detectable at retrospective review of a previously obtained mammogram that was prospectively reported as showing negative, benign, or probably benign findings. Read More

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http://dx.doi.org/10.1148/rg.2020190090DOI Listing

Quantitative chemical imaging of breast calcifications in association with neoplastic processes.

Theranostics 2020 27;10(13):5865-5878. Epub 2020 Apr 27.

Department of Chemistry, University of Washington, Seattle, 98195-1700, USA.

Calcifications play an essential role in early breast cancer detection and diagnosis. However, information regarding the chemical composition of calcifications identified on mammography and histology is limited. Detailed spectroscopy reveals an association between the chemical composition of calcifications and breast cancer, warranting the development of novel analytical tools to better define calcification types. Read More

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http://dx.doi.org/10.7150/thno.43325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254998PMC

DU-Net: Convolutional Network for the Detection of Arterial Calcifications in Mammograms.

IEEE Trans Med Imaging 2020 Apr 23. Epub 2020 Apr 23.

Breast arterial calcifications (BACs) are part of several benign findings present on some mammograms. Previous studies have indicated that BAC may provide evidence of general atherosclerotic vascular disease, and potentially be a useful marker of cardiovascular disease (CVD). Currently, there is no technique in use for the automatic detection of BAC in mammograms. Read More

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http://dx.doi.org/10.1109/TMI.2020.2989737DOI Listing

Performance of 2D Synthetic Mammography Versus Digital Mammography in the Detection of Microcalcifications at Screening.

AJR Am J Roentgenol 2020 06 7;214(6):1436-1444. Epub 2020 Apr 7.

Department of Radiology, Weill Cornell Medicine, 525 E 68th St, New York, NY 10065.

The purpose of this study is to compare the performance of 2D synthetic mammography (SM) to that of full-field digital mammography (FFDM) in the detection of microcalcifications and to evaluate radiologists' preference between the two imaging modalities for assessing calcifications. A fully crossed, mode-balanced, paired-case ( = 160), retrospective, multireader ( = 3) performance study was implemented to compare screening mammograms acquired with digital breast tomosynthesis and both FFDM and SM between 2015 and 2017. The study cohort included 70 patients with mammograms recalled for microcalcifications (35 with malignant findings and 35 with benign findings) and was supplemented with 90 patients with mammograms with negative findings. Read More

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http://dx.doi.org/10.2214/AJR.19.21598DOI Listing

Deep feature-based automatic classification of mammograms.

Med Biol Eng Comput 2020 Jun 21;58(6):1199-1211. Epub 2020 Mar 21.

Indian Institute of Technology Roorkee, Roorkee, India.

Breast cancer has the second highest frequency of death rate among women worldwide. Early-stage prevention becomes complex due to reasons unknown. However, some typical signatures like masses and micro-calcifications upon investigating mammograms can help diagnose women better. Read More

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http://dx.doi.org/10.1007/s11517-020-02150-8DOI Listing

Juvenile papillomatosis of the breast (Swiss cheese disease) has frequent associations with PIK3CA and/or AKT1 mutations.

Hum Pathol 2020 Apr 21;98:64-73. Epub 2020 Feb 21.

Institute of Pathology and Molecular Pathology, University Hospital Zurich, 8091, Switzerland. Electronic address:

Juvenile papillomatosis (JP), the so-called Swiss cheese disease, is a rare benign breast disease of young adults. An association (up to 28%) with breast cancer within the family of affected patients has been reported. A multinodular cystic breast mass lesion and calcifications characterizes JP in imaging studies. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.02.002DOI Listing

Radiologic Findings of a Rare Subtype of Invasive Breast Cancer with Poor Prognosis: Metaplastic Carcinoma of the Breast.

Curr Med Imaging Rev 2019 ;15(3):338-348

Department of Radiology, Dr. AY Ankara Oncology Research and Training Hospital, Ankara, Turkey.

Background And Objectives: The purpose of this study was to evaluate the mammographic, sonographic and MRI findings of metaplastic breast carcinoma.

Methods: In this retrospective review study, we analyzed the medical files of 9600 patients who were treated for invasive breast cancers. Clinical information, histopathologic and radiologic findings of 65 patients were included in this study. Read More

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http://dx.doi.org/10.2174/1573405614666180813120227DOI Listing
January 2019

Discrimination analysis of breast calcifications using x-ray dark-field radiography.

Med Phys 2020 Apr 21;47(4):1813-1826. Epub 2020 Feb 21.

Erlangen Centre for Astroparticle Physics (ECAP), Friedrich-Alexander-University Erlangen-Nuremberg, Erwin-Rommel-Str. 1, D-91058, Erlangen, Germany.

Background: X-ray dark-field radiography could enhance mammography by providing more information on imaged tissue and microcalcifications. The dark field signal is a measure of small angle scattering and can thus provide additional information on the imaged materials. This information can be useful for material distinction of calcifications and the diagnosis of breast cancer by classifying benign and malign association of these calcifications. Read More

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http://dx.doi.org/10.1002/mp.14043DOI Listing

Scoring System to Stratify Malignancy Risks for Mammographic Microcalcifications Based on Breast Imaging Reporting and Data System 5th Edition Descriptors.

Korean J Radiol 2019 12;20(12):1646-1652

Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Objective: To develop a scoring system stratifying the malignancy risk of mammographic microcalcifications using the 5th edition of the Breast Imaging Reporting and Data System (BI-RADS).

Materials And Methods: One hundred ninety-four lesions with microcalcifications for which surgical excision was performed were independently reviewed by two radiologists according to the 5th edition of BI-RADS. Each category's positive predictive value (PPV) was calculated and a scoring system was developed using multivariate logistic regression. Read More

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http://dx.doi.org/10.3348/kjr.2019.0262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6923207PMC
December 2019

Pilomatrixoma, a Rare Mimicker of Male Breast Cancer.

J Clin Imaging Sci 2019 6;9:46. Epub 2019 Nov 6.

Departments of Radiology, Medical University of South Carolina, Charleston, South Carolina, USA.

Pilomatrixoma or calcifying epithelioma of Malherbe is a benign skin tumor arising from the hair follicle; breast occurrence is considered a rarity. Clinically presenting as a palpable abnormality and with both benign and malignant mammographic and sonographic features, it can be easily misdiagnosed as a breast neoplasm. We report a very rare case of pilomatrixoma of the male breast in a 36-year-old male presenting with a firm, superficial nodule in the upper outer quadrant. Read More

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http://dx.doi.org/10.25259/JCIS_64_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884983PMC
November 2019
5 Reads

Calcification Microstructure Reflects Breast Tissue Microenvironment.

J Mammary Gland Biol Neoplasia 2019 12 5;24(4):333-342. Epub 2019 Dec 5.

Cranfield Forensic Institute, Cranfield University, Shrivenham, UK.

Microcalcifications are important diagnostic indicators of disease in breast tissue. Tissue microenvironments differ in many aspects between normal and cancerous cells, notably extracellular pH and glycolytic respiration. Hydroxyapatite microcalcification microstructure is also found to differ between tissue pathologies, including differential ion substitutions and the presence of additional crystallographic phases. Read More

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http://dx.doi.org/10.1007/s10911-019-09441-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908550PMC
December 2019
4.526 Impact Factor

Impact of the Kaiser score on clinical decision-making in BI-RADS 4 mammographic calcifications examined with breast MRI.

Eur Radiol 2020 Mar 3;30(3):1451-1459. Epub 2019 Dec 3.

Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria.

Objectives: To investigate whether the application of the Kaiser score for breast magnetic resonance imaging (MRI) might downgrade breast lesions that present as mammographic calcifications and avoid unnecessary breast biopsies METHODS: This IRB-approved, retrospective, cross-sectional, single-center study included 167 consecutive patients with suspicious mammographic calcifications and histopathologically verified results. These patients underwent a pre-interventional breast MRI exam for further diagnostic assessment before vacuum-assisted stereotactic-guided biopsy (95 malignant and 72 benign lesions). Two breast radiologists with different levels of experience independently read all examinations using the Kaiser score, a machine learning-derived clinical decision-making tool that provides probabilities of malignancy by a formalized combination of diagnostic criteria. Read More

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http://dx.doi.org/10.1007/s00330-019-06444-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033072PMC

The clinical value of detecting microcalcifications on a mammogram.

Semin Cancer Biol 2019 Nov 14. Epub 2019 Nov 14.

Center for Clinical Research Dalarna, Falun, Sweden.

Many breast lesions are associated with microcalcifications that are detectable by mammography. In most cases, radiologists are able to distinguish calcifications usually associated with benign diseases from those associated with malignancy. In addition to their value in the early detection of breast carcinoma and accurate radiological diagnosis, the presence of microcalcifications often affects the extent of surgical intervention. Read More

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http://dx.doi.org/10.1016/j.semcancer.2019.10.024DOI Listing
November 2019

Digital Mammographic Features of Breast Cancer Recurrences and Benign Lesions Mimicking Malignancy Following Breast-Conserving Surgery and Radiation Therapy.

Kurume Med J 2020 Jan 13;65(4):113-121. Epub 2019 Nov 13.

Department of Radiology, Nagoya City University Graduate School of Medical Sciences.

Mammography after breast-conserving surgery and radiation therapy is an important tool for followup. Early diagnosis of local recurrence enables prompt treatment decisions, which may affect patient prognosis. For complicated post-treatment changes, radiologists sometimes have difficulties in interpreting follow-up mammography. Read More

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http://dx.doi.org/10.2739/kurumemedj.MS654005DOI Listing
January 2020

Localized amyloidosis: A diagnostic pitfall in breast pathology.

Pathol Res Pract 2019 Dec 23;215(12):152699. Epub 2019 Oct 23.

Department of Pathology, NYU Langone Health, 550 First Avenue, New York, NY 10016, USA. Electronic address:

Amyloidosis is characterized by extracellular deposition of insoluble protein fibrils in a beta-pleated sheet configuration. Breast amyloidosis is a rare entity which has previously been reported to present with localized involvement, or as a late manifestation of systemic amyloidosis. However, descriptions of the clinicopathologic features of localized breast amyloidosis remain limited. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152699DOI Listing
December 2019

Mammography-based radiomic analysis for predicting benign BI-RADS category 4 calcifications.

Eur J Radiol 2019 Dec 20;121:108711. Epub 2019 Oct 20.

Department of Breast Cancer, Cancer Center, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, 510080, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Purpose: We developed and validated a radiomic model based on mammography and assessed its value for predicting the pathological diagnosis of Breast Imaging Reporting and Data System (BI-RADS) category 4 calcifications.

Materials And Methods: Patients with a total of 212 eligible calcifications were recruited (159 cases in the primary cohort and 53 cases in the validation cohort). In total, 8286 radiomic features were extracted from the craniocaudal (CC) and mediolateral oblique (MLO) images. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.108711DOI Listing
December 2019
2.369 Impact Factor

Giant abdominal tumor - would you think adrenal?

Rom J Morphol Embryol 2019 ;60(2):691-695

Department of Surgery, Faculty of Medicine, "Ovidius" University of Constanţa; Ist Department of Obstetrics and Gynecology, Emergency County Hospital, Constanţa, Romania;

Adrenal cavernomas are rare benign tumors, and those of giant dimensions are exceptional. Usually, they are symptomless or they induce symptoms and signs due to compression over nearby organs. We present the case of a 68-year-old woman, who complained of abdominal enlargement and abdominal pain in the left part of the abdomen. Read More

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March 2020
1 Read

Flat Epithelial Atypia in Breast Core Needle Biopsies With Radiologic-Pathologic Concordance: Is Excision Necessary?

Am J Surg Pathol 2020 02;44(2):182-190

Departments of Pathology.

Flat epithelial atypia (FEA) is an alteration of terminal duct lobular units by a proliferation of ductal epithelium with low-grade atypia. No consensus exists on whether the diagnosis of FEA in core needle biopsy (CNB) requires excision (EXC). We retrospectively identified all in-house CNBs obtained between January 2012 and July 2018 with FEA. Read More

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http://Insights.ovid.com/crossref?an=00000478-900000000-9754
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http://dx.doi.org/10.1097/PAS.0000000000001385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954312PMC
February 2020
13 Reads

Microtomographic characterization of calcifications in canine mammary tumours.

Vet Comp Oncol 2019 Oct 12. Epub 2019 Oct 12.

Centro de Investigação em BioCiências e Tecnologias da Saúde, Faculdade de Medicina Veterinária- Universidade Lusófona de Humanidades e Tecnologias/DNAtech Laboratório Veterinário, Lisboa, Portugal.

The present work describes the microtomographic characterization of macro- and microcalcifications present in excised canine mammary glands. In human breast cancer, microcalcifications are highly relevant for diagnosis and prognosis, often being the sole element determining biopsy. Canine mammary tumours are considered a model for human breast cancer, but the morphological features of calcifications had still to be studied in this species. Read More

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http://dx.doi.org/10.1111/vco.12545DOI Listing
October 2019
2 Reads

Postoperative Cancer Surveillance Following Oncoplastic Surgery with Latissimus Dorsi Flap: a Matched Case-Control Study.

Ann Surg Oncol 2019 Dec 11;26(13):4681-4691. Epub 2019 Oct 11.

Department of Plastic and Reconstructive Surgery, and Institute for Human Tissue Restoration, Yonsei University College of Medicine, Seoul, Korea.

Background: The latissimus dorsi (LD) myocutaneous flap is a widely used local option in oncoplastic surgery for avoiding breast deformities; however, concerns exist regarding its influence in monitoring recurrence. In this study, we evaluated the impact of this flap on postoperative cancer surveillance.

Methods: Each patient receiving oncoplastic surgery with LD flap after partial mastectomy were matched in age, cancer stage, and body mass index with patients receiving partial mastectomy alone. Read More

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http://dx.doi.org/10.1245/s10434-019-07898-4DOI Listing
December 2019
2 Reads
3.930 Impact Factor

Negative prognostic value of intra-ductal fat infiltrate in breast cancer.

Pathol Res Pract 2019 Nov 13;215(11):152634. Epub 2019 Sep 13.

Department of Experimental Medicine, University of Rome "Tor Vergata", Rome, Italy; "Diagnostica Medica" and "Villa dei Platani", Avellino, Italy (Neuromed group), Italy.

Background: Recent studies showed a correlation between Body Mass Index and both breast cancer occurrence and progression. Nevertheless, no study reported an accurate evaluation of intra-ductal fat infiltrate. Therefore, the main aim of this study was to evaluate the putative association between intra-ductal fat infiltrate (IDFi) and breast cancer subtypes by using digital pathology. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152634DOI Listing
November 2019
1 Read

Flat epithelial atypia on core needle biopsy does not always mandate excisional biopsy.

Breast J 2020 Apr 28;26(4):679-684. Epub 2019 Sep 28.

Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, California.

Flat Epithelia Atypia (FEA) is a proliferative lesion of the breast where cells demonstrate columnar change and cytologic atypia. This lesion has been identified as distinct from the classic atypical hyperplasias (AH). While many patients undergo excisional biopsy, management of FEA identified on core needle biopsy (CNB) is controversial, and the rate of associated ductal carcinoma in situ (DCIS) or invasive cancer is not well defined. Read More

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http://dx.doi.org/10.1111/tbj.13507DOI Listing
April 2020
2 Reads

Malignancy rates of stereotactic biopsies of two or more distinct sites of suspicious calcifications in women without known breast cancer.

Clin Imaging 2019 Nov - Dec;58:156-160. Epub 2019 Jul 23.

Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Objective: To determine the malignancy rate in women without a concurrent breast cancer diagnosis at presentation who underwent stereotactic biopsies of distinct sites of suspicious calcifications.

Methods: This retrospective study included 280 women without a concurrent breast cancer diagnosis who underwent 587 stereotactic biopsies of two or more distinct sites of suspicious calcifications in one or both breasts at our institution from 2010 to 2015.

Results: The overall malignancy rate was 27. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.07.007DOI Listing
March 2020
5 Reads

Benign breast papillary lesions diagnosed on core biopsy: upgrade rate and risk factors associated with malignancy on surgical excision.

Virchows Arch 2019 Dec 1;475(6):701-707. Epub 2019 Aug 1.

Department of Pathology and Molecular Medicine, Juravinski Hospital - Hamilton Health Sciences, 711 Concession St, Hamilton, ON, L8V 1C3, Canada.

Evaluation of radiologically detected breast lesions is a common task in surgical pathology. Some benign lesions on biopsy are associated with an upgrade to in situ or invasive carcinoma on excision. The non-atypical breast papilloma has published upgrade rates of 0 to 29%. Read More

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http://dx.doi.org/10.1007/s00428-019-02626-5DOI Listing
December 2019
1 Read

Unusual Changing Calcification Patterns on the Mammogram in a Pure Mucocele-Like Lesion of the Breast: A Case Report.

Am J Case Rep 2019 Jun 29;20:926-932. Epub 2019 Jun 29.

Department of Pathology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.

BACKGROUND Mucocele-like lesions are rare breast lesions composed of mucin filled cysts and extravasated mucin that frequently undergo calcification. The most common radiologic feature of a mucocele-like lesion is mammographic microcalcifications of indeterminate nature. The present report demonstrated unusual fluctuation of calcification number and a changing pattern of calcification morphology on mammography in a benign mucocele-like lesion. Read More

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http://dx.doi.org/10.12659/AJCR.916335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613490PMC
June 2019
2 Reads

Growth Dynamics of Mammographic Calcifications: Differentiating Ductal Carcinoma in Situ from Benign Breast Disease.

Radiology 2019 07 21;292(1):77-83. Epub 2019 May 21.

From the Departments of Radiology (L.J.G., J.Y.L.), Biostatistics & Bioinformatics (S.M.T., Y.L., T.H.), Surgery (E.S.H.), and Population Health Sciences (M.D.R.), Duke University Medical Center, 40 Duke Medicine Circle, DUMC Box 3808, Durham, NC 27710; and the Department of Radiology (M.M.M.), University of Virginia Health System, 1215 Lee St, Charlottesville, VA 22903.

Background Most ductal carcinoma in situ (DCIS) lesions are first detected on screening mammograms as calcifications. However, false-positive biopsy rates for calcifications range from 30% to 87%. Improved methods to differentiate benign from malignant calcifications are thus needed. Read More

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http://dx.doi.org/10.1148/radiol.2019182599DOI Listing
July 2019
5 Reads

A Hybridized ELM for Automatic Micro Calcification Detection in Mammogram Images Based on Multi-Scale Features.

J Med Syst 2019 May 15;43(7):183. Epub 2019 May 15.

Department of Electronics and Communication Engineering, Toc H Institute of Science and Technology, Ernakulam, Kerala, India.

Detection of masses and micro calcifications are a stimulating task for radiologists in digital mammogram images. Radiologists using Computer Aided Detection (CAD) frameworks to find the breast lesion. Micro calcification may be the early sign of breast cancer. Read More

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http://dx.doi.org/10.1007/s10916-019-1316-3DOI Listing
May 2019
9 Reads

Computer-Aided Diagnosis of Solid Breast Lesions With Ultrasound: Factors Associated With False-negative and False-positive Results.

J Ultrasound Med 2019 Dec 11;38(12):3193-3202. Epub 2019 May 11.

Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Objectives: To investigate factors that may lead to false-positive or false-negative results in a computer-aided diagnostic system (S-Detect; Samsung Medison Co, Ltd, Seoul, Korea) for ultrasound (US) examinations of solid breast lesions.

Methods: This prospective study was approved by the Institutional Review Board of Sun Yat-sen Memorial Hospital. All patients signed and provided written informed consent before biopsy or surgery. Read More

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http://dx.doi.org/10.1002/jum.15020DOI Listing
December 2019
5 Reads

Value of Shear Wave Elastography for the Differentiation of Benign and Malignant Microcalcifications of the Breast.

AJR Am J Roentgenol 2019 08 30;213(2):W85-W92. Epub 2019 Apr 30.

1 Department of Radiology, McGill University Health Center, Montreal, QC, Canada.

The objective of our study was to evaluate whether shear wave elastography (SWE) can differentiate benign from malignant microcalcifications of the breast when detected on ultrasound (US). Between February 9, and June 23, 2016, 74 patients with mammographically detected suspicious microcalcifications underwent breast US. When microcalcifications were identified on US, stiffness was assessed using SWE. Read More

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http://dx.doi.org/10.2214/AJR.18.20899DOI Listing
August 2019
10 Reads

Classification of breast microcalcifications using dual-energy mammography.

J Med Imaging (Bellingham) 2019 Jan 12;6(1):013502. Epub 2019 Mar 12.

U.S. Food and Drug Administration, CDRH, Division of Imaging Diagnostics and Software Reliability, Silver Spring, Maryland, United States.

The potential of dual-energy mammography for microcalcification classification was investigated with simulation and phantom studies. Classification of type I/II calcifications was performed using the tissue attenuation ratio as a performance metric. The simulation and phantom studies were carried out using breast phantoms of 50% fibroglandular and 50% adipose tissue composition and thicknessess ranging from 3 to 6 cm. Read More

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http://dx.doi.org/10.1117/1.JMI.6.1.013502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411940PMC
January 2019
3 Reads

Stromal Fibrosis of the Breast: A Spectrum of Benign to Malignant Imaging Appearances.

Radiol Res Pract 2019 3;2019:5045908. Epub 2019 Feb 3.

Department of Diagnostic Radiology, American University of Beirut Medical Center, Lebanon.

Objectives: The aim of this study is to demonstrate the various imaging appearances of stromal fibrosis on mammography, ultrasound, and magnetic resonance imaging (MRI).

Material And Methods: This study included 75 female patients who presented to the American University of Beirut Medical Center between January 2010 and October 2015 for breast imaging. 66 (88%) patients obtained a mammogram, 71 (95%) had an ultrasound, and 6 (8%) had an MRI. Read More

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http://dx.doi.org/10.1155/2019/5045908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388321PMC
February 2019
12 Reads

Dedicated Breast Computed Tomography With a Photon-Counting Detector: Initial Results of Clinical In Vivo Imaging.

Invest Radiol 2019 07;54(7):409-418

Institute of Medical Physics, University of Erlangen-Nürnberg, Germany.

Objectives: The purpose of this work is to present the data obtained from the first clinical in vivo application of a new dedicated spiral breast computed tomography (B-CT) equipped with a photon-counting detector.

Materials And Methods: The institutional review board approved this retrospective study. Twelve women referred for breast cancer screening were included and underwent bilateral spiral B-CT acquired in prone position. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000552DOI Listing
July 2019
23 Reads

Conspicuity of suspicious breast lesions on contrast enhanced breast CT compared to digital breast tomosynthesis and mammography.

Br J Radiol 2019 May 3;92(1097):20181034. Epub 2019 Apr 3.

1 Department of Radiology, University of California Davis Medical Center , California , USA.

Objective: Compare conspicuity of suspicious breast lesions on contrast-enhanced dedicated breast CT (CEbCT), tomosynthesis (DBT) and digital mammography (DM).

Methods: 100 females with BI-RADS 4/5 lesions underwent CEbCT and/or DBT prior to biopsy in this IRB approved, HIPAA compliant study. Two breast radiologists adjudicated lesion conspicuity scores (CS) for each modality independently. Read More

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http://dx.doi.org/10.1259/bjr.20181034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580915PMC
May 2019
10 Reads

Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations: A Comparison With Full-field Digital Mammography.

Comput Struct Biotechnol J 2019 20;17:82-89. Epub 2018 Dec 20.

Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.

The diagnostic performance difference between digital breast tomosynthesis (DBT) and conventional full-field digital mammography (FFDM) for breast suspicious calcifications from various populations is unclear. The objective of this study is to determine whether DBT exhibits the diagnostic advantage for breast suspicious calcifications from various populations compared with FFDM. Three hundred and five patients were enrolled (of which seven patients with bilateral lesions) and 312 breasts images were retrospectively analyzed by three radiologists independently. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20010370183015
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http://dx.doi.org/10.1016/j.csbj.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317146PMC
December 2018
29 Reads

Diagnostic performance of ultrasound strain elastography for differentiation of malignant breast lesions.

Clin Hemorheol Microcirc 2019 ;71(2):237-247

Department of Radiology, University Hospital Regensburg, Germany.

Objective: Objective of the study was to assess the performance of ultrasound strain elastography combined with conventional B-mode ultrasound to diagnose suspicious breast lesions (BI-RADS 4 and 5).

Methods: Between January 2015 and December 2017, a total of 86 patients (55±17.9 years) with solid or unclear, non-cystic breast lesions were enrolled in the study. Read More

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http://dx.doi.org/10.3233/CH-189415DOI Listing
June 2019
3 Reads

A diagnostic strategy for breast calcifications based on a long-term follow-up of 615 lesions.

Jpn J Radiol 2019 Mar 19;37(3):237-244. Epub 2018 Dec 19.

Breast Oncology Center, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Purpose: To clarify the long-term outcomes of breast calcifications after stereotactic vacuum-assisted breast biopsy (SVAB) and to develop strategy after SVAB.

Methods: Subject comprised 594 patients with 615 calcifications who underwent SVAB. 371 (60. Read More

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http://link.springer.com/10.1007/s11604-018-0803-7
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http://dx.doi.org/10.1007/s11604-018-0803-7DOI Listing
March 2019
38 Reads

Characterization of Breast Microcalcifications Using a New Ultrasound Image-Processing Technique.

J Ultrasound Med 2019 Jul 13;38(7):1733-1738. Epub 2018 Nov 13.

Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objectives: To evaluate a new commercial image-processing technique (MicroPure; Toshiba America Medical Systems, Tustin, CA) for detection and characterization of breast microcalcifications in patients undergoing stereotactic or ultrasound-guided biopsies using mammography as the reference standard.

Methods: One hundred female patients, with a total of 104 lesions, scheduled for an image-guided biopsy of an area with breast microcalcifications (identified on a prior mammogram) underwent MicroPure examinations of the breast using an Aplio XG scanner (Toshiba America Medical Systems) with a broad-bandwidth linear array. MicroPure combines nonlinear imaging and speckle suppression to mark suspected calcifications as white spots in a blue overlay image. Read More

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http://doi.wiley.com/10.1002/jum.14861
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http://dx.doi.org/10.1002/jum.14861DOI Listing
July 2019
23 Reads

Comparison of breast cancer detection and depiction between planar and rotating synthetic mammography generated from breast tomosynthesis.

Eur J Radiol 2018 Nov 19;108:78-83. Epub 2018 Sep 19.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

Purpose: To compare breast cancer detection and depiction between planar synthetic mammography (SM) and rotating synthetic mammography (RM) generated from digital breast tomosynthesis (DBT).

Materials And Methods: In a fully-crossed multi-reader multi-case (MRMC) study, three radiologists retrospectively reviewed 190 cases (27 malignant, 31 benign, 132 normal), once with SM alone and once with RM alone, the DBT stack of slices was not reviewed. Lesions were scored using BI-RADS® and level of suspiciousness (1-10). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.022DOI Listing
November 2018
32 Reads

Radiological findings of breast involvement in benign and malignant systemic diseases.

Radiol Bras 2018 Sep-Oct;51(5):328-333

Department of Radiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.

Although the primary purpose of periodic mammograms in screening programs is to identify lesions suspected of being carcinomas, the findings are often related to systemic (benign or malignant) diseases, rather than breast cancer. Although the involvement of breast structures in systemic diseases is unusual, it can be included in the differential diagnosis of masses, skin changes, calcifications, asymmetry, and axillary lymphadenopathy. The main diagnostic entities that can be associated with such involvement are diabetes, chronic kidney disease, heart diseases, connective tissue diseases, HIV infection, lymphoma, leukemia, and metastases from primary tumors at other sites. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2016.0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198842PMC
October 2018
9 Reads

Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment.

Surg Innov 2019 Feb 7;26(1):50-56. Epub 2018 Oct 7.

3 Johns Hopkins Hospital, Baltimore, MD, USA.

Purpose: Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Read More

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http://journals.sagepub.com/doi/10.1177/1553350618803245
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http://dx.doi.org/10.1177/1553350618803245DOI Listing
February 2019
16 Reads

A case of primary extraskeletal osteosarcoma of the breast.

Surg Case Rep 2018 Sep 19;4(1):121. Epub 2018 Sep 19.

Department of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku Kokurakita-ku, Kitakyushu, Fukuoka, 802-0077, Japan.

Background: Primary sarcomas of the breast are rare and account for less than 1% of all primary breast malignancies. We experienced a case of extraskeletal osteosarcoma of the breast that had a unique clinical course and remarkable findings of mammography and magnetic resonance imaging (MRI). A review of the case reports published in the past few decades showed no reports of a case in which a calcified lesion was followed up three different times on mammography, making this a valuable case report. Read More

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http://dx.doi.org/10.1186/s40792-018-0530-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146110PMC
September 2018
34 Reads

Diagnostic difficulties of primary angiosarcoma of the breast: a case report.

J Med Case Rep 2018 Aug 22;12(1):228. Epub 2018 Aug 22.

Department of Pathology, Gyneco-Obstetric and Pediatric Hospital, Ibn Sina University Hospital, Rabat, Morocco.

Background: Angiosarcoma of the breast is a rare tumor, which may be primary or secondary to breast surgery or irradiation. It is characterized by polymorphic and nonspecific clinical and radiological features. A pathologist plays a key role in positive and differential diagnosis and in establishing the prognosis: only a histological examination can confirm the diagnosis, and the histologic grade is the most important prognostic factor. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1772-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103999PMC
August 2018
40 Reads

Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women.

Medicine (Baltimore) 2018 Aug;97(31):e11412

Breast Unit, Department of Surgery.

Phyllodes tumor or cystosarcoma phyllodes is a rare fibroepithelial neoplasm which arises from the periductal stroma of the breast. They are classified as benign, borderline, and malignant based on the histologic features. However, all phyllodes tumor (PT) subtypes are regarded as having malignant potential and correct diagnosis is important for surgical management and optimal care. Read More

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http://dx.doi.org/10.1097/MD.0000000000011412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081195PMC
August 2018
12 Reads

Mammography-detected ultrasound-negative asymptomatic micro-calcifications in Chinese women: Would it be safe to watch and wait?

Med Hypotheses 2018 Sep 18;118:9-12. Epub 2018 Jun 18.

Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China. Electronic address:

Although mammography (MG) has been widely used for breast cancer screening in the western world, over-diagnosis remains controversial. Milestone studies showed that ultrasound (US) was an effective primary screening test for breast cancer both in the western world and in China. US improves the sensitivity of screening in Chinese women who have denser breasts and develop breast cancer earlier than Caucasian counterparts, and is used as the primary imaging test in the hospital-based opportunistic screening among asymptomatic self-referred women. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183032
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http://dx.doi.org/10.1016/j.mehy.2018.06.012DOI Listing
September 2018
42 Reads

Dystrophic Calcifications in the Breast from Secondary Hyperparathyroidism.

Breast Care (Basel) 2018 Mar 12;13(1):44-46. Epub 2018 Jan 12.

Department of Surgery, Ewha Womans University, School of Medicine, Seoul, Republic of Korea.

Background: Soft tissue calcification is common in patients with secondary hyperparathyroidism who have received long-term treatment with hemodialysis. However, calcifications in the breast parenchyma are not common. We report a case of a woman with dystrophic breast calcifications from secondary hyperparathyroidism. Read More

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http://dx.doi.org/10.1159/000484198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016053PMC
March 2018
13 Reads

Suspicious amorphous microcalcifications detected on full-field digital mammography: correlation with histopathology.

Radiol Bras 2018 Mar-Apr;51(2):87-94

MD, PhD, Tenured Professor, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

Objective: To evaluate suspicious amorphous calcifications diagnosed on full-field digital mammography (FFDM) and establish correlations with histopathology findings.

Materials And Methods: This was a retrospective study of 78 suspicious amorphous calcifications (all classified as BI-RADS 4) detected on FFDM. Vacuum-assisted breast biopsy (VABB) was performed. Read More

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http://dx.doi.org/10.1590/0100-3984.2017.0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935401PMC
May 2018
22 Reads

Primary breast osteosarcoma mimicking calcified fibroadenoma on screening digital breast tomosynthesis mammogram.

Radiol Case Rep 2017 Dec 29;12(4):648-652. Epub 2017 Jul 29.

Department of Radiology, St. Louis University Hospital, 3655 Vista Ave., St. Louis, MO 63110, USA.

Primary breast osteosarcoma is a rare malignancy, with mostly case reports in the literature. The appearance of breast osteosarcoma on digital breast tomosynthesis imaging has not yet been described. A 69-year-old woman presents for routine screening mammography and is found to have a calcified mass in her right breast. Read More

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http://dx.doi.org/10.1016/j.radcr.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823318PMC
December 2017
7 Reads