489 results match your criteria Breast Benign Calcifications


Contrast-enhanced spectral mammography in the evaluation of breast suspicious calcifications: diagnostic accuracy and impact on surgical management.

Acta Radiol 2019 Jan 24:284185118822639. Epub 2019 Jan 24.

1 Department of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

Background: Detecting pathological breast calcifications remains challenging. Based on recent studies, contrast-enhanced spectral mammography (CESM) was shown to be superior compared to full-field digital mammography (FFDM).

Purpose: To evaluate the diagnostic accuracy of CESM in suspicious breast calcifications and its impact on surgical decision-making. Read More

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http://dx.doi.org/10.1177/0284185118822639DOI Listing
January 2019
1 Read

Diagnostic Performance of Digital Breast Tomosynthesis for Breast Suspicious Calcifications From Various Populations: A Comparison With Full-field Digital Mammography.

Comput Struct Biotechnol J 2019 20;17:82-89. Epub 2018 Dec 20.

Department of Medical Oncology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450008, China.

The diagnostic performance difference between digital breast tomosynthesis (DBT) and conventional full-field digital mammography (FFDM) for breast suspicious calcifications from various populations is unclear. The objective of this study is to determine whether DBT exhibits the diagnostic advantage for breast suspicious calcifications from various populations compared with FFDM. Three hundred and five patients were enrolled (of which seven patients with bilateral lesions) and 312 breasts images were retrospectively analyzed by three radiologists independently. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20010370183015
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http://dx.doi.org/10.1016/j.csbj.2018.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317146PMC
December 2018
2 Reads

Diagnostic performance of ultrasound strain elastography for differentiation of malignant breast lesions.

Clin Hemorheol Microcirc 2018 Dec 18. Epub 2018 Dec 18.

Department of Radiology, University Hospital Regensburg, Germany.

Objective: Objective of the study was to assess the performance of ultrasound strain elastography combined with conventional B-mode ultrasound to diagnose suspicious breast lesions (BI-RADS 4 and 5).

Methods: Between January 2015 and December 2017, a total of 86 patients (55±17.9 years) with solid or unclear, non-cystic breast lesions were enrolled in the study. Read More

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http://dx.doi.org/10.3233/CH-189415DOI Listing
December 2018
1 Read

A diagnostic strategy for breast calcifications based on a long-term follow-up of 615 lesions.

Jpn J Radiol 2018 Dec 19. Epub 2018 Dec 19.

Breast Oncology Center, The Cancer Institute Hospital of the Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.

Purpose: To clarify the long-term outcomes of breast calcifications after stereotactic vacuum-assisted breast biopsy (SVAB) and to develop strategy after SVAB.

Methods: Subject comprised 594 patients with 615 calcifications who underwent SVAB. 371 (60. Read More

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http://link.springer.com/10.1007/s11604-018-0803-7
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http://dx.doi.org/10.1007/s11604-018-0803-7DOI Listing
December 2018
10 Reads

Characterization of Breast Microcalcifications Using a New Ultrasound Image-Processing Technique.

J Ultrasound Med 2018 Nov 13. Epub 2018 Nov 13.

Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Objectives: To evaluate a new commercial image-processing technique (MicroPure; Toshiba America Medical Systems, Tustin, CA) for detection and characterization of breast microcalcifications in patients undergoing stereotactic or ultrasound-guided biopsies using mammography as the reference standard.

Methods: One hundred female patients, with a total of 104 lesions, scheduled for an image-guided biopsy of an area with breast microcalcifications (identified on a prior mammogram) underwent MicroPure examinations of the breast using an Aplio XG scanner (Toshiba America Medical Systems) with a broad-bandwidth linear array. MicroPure combines nonlinear imaging and speckle suppression to mark suspected calcifications as white spots in a blue overlay image. Read More

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http://doi.wiley.com/10.1002/jum.14861
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http://dx.doi.org/10.1002/jum.14861DOI Listing
November 2018
9 Reads

Comparison of breast cancer detection and depiction between planar and rotating synthetic mammography generated from breast tomosynthesis.

Eur J Radiol 2018 Nov 19;108:78-83. Epub 2018 Sep 19.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB Nijmegen, the Netherlands.

Purpose: To compare breast cancer detection and depiction between planar synthetic mammography (SM) and rotating synthetic mammography (RM) generated from digital breast tomosynthesis (DBT).

Materials And Methods: In a fully-crossed multi-reader multi-case (MRMC) study, three radiologists retrospectively reviewed 190 cases (27 malignant, 31 benign, 132 normal), once with SM alone and once with RM alone, the DBT stack of slices was not reviewed. Lesions were scored using BI-RADS® and level of suspiciousness (1-10). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.022DOI Listing
November 2018
9 Reads

Radiological findings of breast involvement in benign and malignant systemic diseases.

Radiol Bras 2018 Sep-Oct;51(5):328-333

Department of Radiology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, SP, Brazil.

Although the primary purpose of periodic mammograms in screening programs is to identify lesions suspected of being carcinomas, the findings are often related to systemic (benign or malignant) diseases, rather than breast cancer. Although the involvement of breast structures in systemic diseases is unusual, it can be included in the differential diagnosis of masses, skin changes, calcifications, asymmetry, and axillary lymphadenopathy. The main diagnostic entities that can be associated with such involvement are diabetes, chronic kidney disease, heart diseases, connective tissue diseases, HIV infection, lymphoma, leukemia, and metastases from primary tumors at other sites. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/0100-3984.2016.0125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198842PMC
October 2018
4 Reads

Interpretation of Optical Coherence Tomography Images for Breast Tissue Assessment.

Surg Innov 2018 Oct 7:1553350618803245. Epub 2018 Oct 7.

3 Johns Hopkins Hospital, Baltimore, MD, USA.

Purpose: Initial studies have shown that optical coherence tomography (OCT) is an effective margin-evaluation tool for breast-conserving surgery, but methods for the interpretation of breast OCT images have not been directly studied. In this work, breast pathologies were assessed with a handheld OCT probe. OCT images and corresponding histology were used to develop guidelines for the identification of breast tissue features in OCT images. Read More

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http://journals.sagepub.com/doi/10.1177/1553350618803245
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http://dx.doi.org/10.1177/1553350618803245DOI Listing
October 2018
7 Reads

A case of primary extraskeletal osteosarcoma of the breast.

Surg Case Rep 2018 Sep 19;4(1):121. Epub 2018 Sep 19.

Department of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku Kokurakita-ku, Kitakyushu, Fukuoka, 802-0077, Japan.

Background: Primary sarcomas of the breast are rare and account for less than 1% of all primary breast malignancies. We experienced a case of extraskeletal osteosarcoma of the breast that had a unique clinical course and remarkable findings of mammography and magnetic resonance imaging (MRI). A review of the case reports published in the past few decades showed no reports of a case in which a calcified lesion was followed up three different times on mammography, making this a valuable case report. Read More

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http://dx.doi.org/10.1186/s40792-018-0530-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146110PMC
September 2018
2 Reads

Diagnostic difficulties of primary angiosarcoma of the breast: a case report.

J Med Case Rep 2018 Aug 22;12(1):228. Epub 2018 Aug 22.

Department of Pathology, Gyneco-Obstetric and Pediatric Hospital, Ibn Sina University Hospital, Rabat, Morocco.

Background: Angiosarcoma of the breast is a rare tumor, which may be primary or secondary to breast surgery or irradiation. It is characterized by polymorphic and nonspecific clinical and radiological features. A pathologist plays a key role in positive and differential diagnosis and in establishing the prognosis: only a histological examination can confirm the diagnosis, and the histologic grade is the most important prognostic factor. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1772-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103999PMC
August 2018
14 Reads

Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women.

Medicine (Baltimore) 2018 Aug;97(31):e11412

Breast Unit, Department of Surgery.

Phyllodes tumor or cystosarcoma phyllodes is a rare fibroepithelial neoplasm which arises from the periductal stroma of the breast. They are classified as benign, borderline, and malignant based on the histologic features. However, all phyllodes tumor (PT) subtypes are regarded as having malignant potential and correct diagnosis is important for surgical management and optimal care. Read More

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http://dx.doi.org/10.1097/MD.0000000000011412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081195PMC
August 2018
5 Reads

Mammography-detected ultrasound-negative asymptomatic micro-calcifications in Chinese women: Would it be safe to watch and wait?

Med Hypotheses 2018 Sep 18;118:9-12. Epub 2018 Jun 18.

Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China. Electronic address:

Although mammography (MG) has been widely used for breast cancer screening in the western world, over-diagnosis remains controversial. Milestone studies showed that ultrasound (US) was an effective primary screening test for breast cancer both in the western world and in China. US improves the sensitivity of screening in Chinese women who have denser breasts and develop breast cancer earlier than Caucasian counterparts, and is used as the primary imaging test in the hospital-based opportunistic screening among asymptomatic self-referred women. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03069877183032
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http://dx.doi.org/10.1016/j.mehy.2018.06.012DOI Listing
September 2018
18 Reads

Dystrophic Calcifications in the Breast from Secondary Hyperparathyroidism.

Breast Care (Basel) 2018 Mar 12;13(1):44-46. Epub 2018 Jan 12.

Department of Surgery, Ewha Womans University, School of Medicine, Seoul, Republic of Korea.

Background: Soft tissue calcification is common in patients with secondary hyperparathyroidism who have received long-term treatment with hemodialysis. However, calcifications in the breast parenchyma are not common. We report a case of a woman with dystrophic breast calcifications from secondary hyperparathyroidism. Read More

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http://dx.doi.org/10.1159/000484198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6016053PMC
March 2018
10 Reads

Suspicious amorphous microcalcifications detected on full-field digital mammography: correlation with histopathology.

Radiol Bras 2018 Mar-Apr;51(2):87-94

MD, PhD, Tenured Professor, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.

Objective: To evaluate suspicious amorphous calcifications diagnosed on full-field digital mammography (FFDM) and establish correlations with histopathology findings.

Materials And Methods: This was a retrospective study of 78 suspicious amorphous calcifications (all classified as BI-RADS 4) detected on FFDM. Vacuum-assisted breast biopsy (VABB) was performed. Read More

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http://dx.doi.org/10.1590/0100-3984.2017.0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935401PMC
May 2018
6 Reads

Primary breast osteosarcoma mimicking calcified fibroadenoma on screening digital breast tomosynthesis mammogram.

Radiol Case Rep 2017 Dec 29;12(4):648-652. Epub 2017 Jul 29.

Department of Radiology, St. Louis University Hospital, 3655 Vista Ave., St. Louis, MO 63110, USA.

Primary breast osteosarcoma is a rare malignancy, with mostly case reports in the literature. The appearance of breast osteosarcoma on digital breast tomosynthesis imaging has not yet been described. A 69-year-old woman presents for routine screening mammography and is found to have a calcified mass in her right breast. Read More

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http://dx.doi.org/10.1016/j.radcr.2017.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823318PMC
December 2017
2 Reads

Added value of second biopsy target in screen-detected widespread suspicious breast calcifications.

J Med Imaging Radiat Oncol 2018 Jun 22;62(3):299-306. Epub 2018 Feb 22.

Department of Radiology, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.

Introduction: There is controversy on the optimal work-up of screen-detected widespread breast calcifications: whether to biopsy a single target or multiple targets. This study evaluates agreement between multiple biopsy targets within the same screen-detected widespread (≥25 mm) breast calcification to determine if the second biopsy adds value.

Methods: Retrospective observational study of women screened in a statewide general population risk breast cancer mammographic screening program from 2009 to 2016. Read More

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http://dx.doi.org/10.1111/1754-9485.12715DOI Listing
June 2018
5 Reads

Vacuum assisted breast biopsy (VAB) excision of subcentimeter microcalcifications as an alternative to open biopsy for atypical ductal hyperplasia.

Br J Radiol 2018 May 23;91(1085):20180003. Epub 2018 Feb 23.

1 Department of Radiology, University of Genoa , Genoa , Italy.

Objective: Atypical ductal hyperplasia (ADH) is a proliferative lesion associated with a variable increased risk of breast malignancy, but the management of the patients is still not completely defined, with mandatory surgical excision in most cases. To report the results of the conservative management with mammographic checks of patients with ADH diagnosed by vacuum assisted breast biopsy (VAB), without residual calcifications.

Methods: The authors accessed the institutional database of radiological, surgical and pathological anatomy. Read More

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http://dx.doi.org/10.1259/bjr.20180003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190792PMC
May 2018
8 Reads

Chest wall - a structure underestimated in ultrasonography. Part III: Neoplastic lesions.

J Ultrason 2017 Dec 29;17(71):281-288. Epub 2017 Dec 29.

Self-education Sonography Group, Genetics Division, Pomeranian Medical University, Szczecin, Poland.

Chest wall neoplasms mainly include malignancies, metastatic in particular. Differential diagnosis should include clinical data; tumor location, extent, delineation; the degree of homogeneity; the presence of calcifications; the nature of bone destruction and the degree of vascularization. The aim of the paper is to present both the benefits and limitations of ultrasound for the diagnosis of chest wall neoplasms. Read More

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http://dx.doi.org/10.15557/JoU.2017.0041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769669PMC
December 2017
9 Reads

Classification of micro-calcification in mammograms using scalable linear Fisher discriminant analysis.

Med Biol Eng Comput 2018 Aug 25;56(8):1475-1485. Epub 2018 Jan 25.

Aberystwyth University, Aberystwyth, UK.

Breast cancer is one of the major causes of death in women. Computer Aided Diagnosis (CAD) systems are being developed to assist radiologists in early diagnosis. Micro-calcifications can be an early symptom of breast cancer. Read More

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http://dx.doi.org/10.1007/s11517-017-1774-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6061516PMC
August 2018
3 Reads

Breast imaging in patients with nipple discharge.

Radiol Bras 2017 Nov-Dec;50(6):383-388

Member of the Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR), MD, Radiologist at Conrad Diagnóstico por Imagem, Belo Horizonte, MG, Brazil.

Nipple discharge is a common symptom in clinical practice, representing the third leading breast complaint, after pain and lumps. It is usually limited and has a benign etiology. The risk of malignancy is higher when the discharge is uniductal, unilateral, spontaneous, persistent, bloody, or serous, as well as when it is accompanied by a breast mass. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/0100-3984.2016.0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5746883PMC
January 2018
9 Reads

Incidence of inflammatory breast cancer in patients with clinical inflammatory breast symptoms.

PLoS One 2017 20;12(12):e0189385. Epub 2017 Dec 20.

Faculté de médecine de Créteil UPEC-Paris XII, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Centre Hospitalier Intercommunal de Créteil, Créteil-France.

Background: To describe a large cohort of women with non-puerperal inflammatory breast and to identify characteristics of inflammatory breast cancer.

Methods: All patients consulting for inflammatory breast syndrome in the breast unit of our tertiary University hospital between September 2013 and December 2015 were prospectively included. We excluded women who were pregnant or in the postpartum period. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0189385PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5738061PMC
January 2018
14 Reads

Association between mammographic breast density and histologic features of benign breast disease.

Breast Cancer Res 2017 Dec 19;19(1):134. Epub 2017 Dec 19.

Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Background: Over 40% of women undergoing breast screening have mammographically dense breasts. Elevated mammographic breast density (MBD) is an established breast cancer risk factor and is known to mask tumors within the dense tissue. However, the association of MBD with high risk benign breast disease (BBD) is unknown. Read More

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http://dx.doi.org/10.1186/s13058-017-0922-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735506PMC
December 2017
19 Reads

Microcalcification morphological descriptors and parenchyma fractal dimension hierarchically interact in breast cancer: A diagnostic perspective.

Comput Biol Med 2018 02 11;93:1-6. Epub 2017 Dec 11.

Environment and Health Dept., Istituto Superiore di Sanità, Roma, Italy; Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti-Pescara Chieti, Italy. Electronic address:

Introduction: Herein, we propose a Systems Biology approach aimed at identifying quantitative morphological parameters useful in discriminating benign from malignant breast microcalcifications at digital mammography.

Materials And Methods: The study includes 31 patients in which microcalcifications had been detected during XR mammography and were further confirmed by stereotactic (XR-guided) biopsies. Patients were classified according to the BIRADS (Breast Imaging-Reporting and Data System), along with their parenchyma fractal dimension and biopsy size. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2017.12.004DOI Listing
February 2018
17 Reads

Body Art Confounding a Case of Breast Cancer.

Ochsner J 2017 ;17(4):430-433

Department of Radiology, Ochsner Clinic Foundation, New Orleans, LA.

Background: Heavy metals in tattoo ink can be deposited in axillary lymph nodes, mimicking malignant calcifications. High-density foci in axillary lymph nodes can be the sequelae of a benign or malignant process.

Case Report: A 34-year-old female presented with left breast discomfort. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718459PMC
January 2017
8 Reads

Rapid Differential Diagnosis of Breast Microcalcification Using Targeted Near-Infrared Fluorophores.

Adv Healthc Mater 2018 Apr 6;7(7):e1701062. Epub 2017 Dec 6.

Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju, 61469, South Korea.

Early detection and differential diagnosis of breast microcalcifications are of significant importance in effective treatment of early breast cancer, because mineral composition of breast calcification is directly associated with different pathological states. However, applying image-based modalities for component identification in breast calcification remains challenging, because no calcification-specific contrast agent is available to distinguish between benign and malignant (type I and type II, respectively) calcifications of breast lesions. In this study, real-time near-infrared (NIR) fluorescence imaging of breast microcalcifications using targeted NIR fluorophores in combination with dual-channel NIR fluorescence imaging system is reported. Read More

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http://dx.doi.org/10.1002/adhm.201701062DOI Listing
April 2018
4 Reads

Erythematous, friable nipple with loss of protrusion · history of breastfeeding · Dx?

J Fam Pract 2017 Dec;66(12):758-760

University of Virginia, School of Nursing, Charlottesville, VA, USA. Email:

A 34-year-old healthy woman presented to the breast surgical oncology clinic with skin changes to her left nipple after being referred by her primary care provider. She attributed the skin changes to shearing from breastfeeding her third child 5 years earlier. Physical examination revealed an erythematous and friable nipple with loss of protrusion. Read More

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December 2017
4 Reads

Intra-operative radiotherapy management for breast cancer treatment in patients with pseudoxanthoma elasticum: A case report.

Breast J 2018 05 5;24(3):385-387. Epub 2017 Nov 5.

Division of Surgical Senology, European Institute of Oncology, Milano, Italy.

Pseudoxanthoma elasticum is a systemic metabolic disease presenting calcifications and progressive fragmentation of elastic fibers. Actually, no targeted therapies are available for the treatment; only prevention of complications is possible. Classically, pseudoxanthoma elasticum is a "benign" disease, without cancer association. Read More

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http://dx.doi.org/10.1111/tbj.12944DOI Listing
May 2018
16 Reads

Mucocele-like lesions diagnosed on breast core biopsy: Low risk of upgrade and subsequent carcinoma.

Breast J 2018 05 11;24(3):314-318. Epub 2017 Oct 11.

Department of Pathology, Robert J. Tomisch Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.

Mucocele-like lesions of the breast diagnosed on core biopsy are usually excised to exclude the possibility of partial sampling of an invasive mucinous carcinoma. The goal of this study was to correlate the pathologic and radiologic features of mucocele-like lesions to determine if excision is mandatory. Over a 16 year period we identified 32 patients with mucocele-like lesions diagnosed on 27 (84%) stereotactic and 5 (16%) ultrasound-guided core biopsies. Read More

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http://doi.wiley.com/10.1111/tbj.12929
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http://dx.doi.org/10.1111/tbj.12929DOI Listing
May 2018
20 Reads

Automated Analysis of Unregistered Multi-View Mammograms With Deep Learning.

IEEE Trans Med Imaging 2017 11 12;36(11):2355-2365. Epub 2017 Sep 12.

We describe an automated methodology for the analysis of unregistered cranio-caudal (CC) and medio-lateral oblique (MLO) mammography views in order to estimate the patient's risk of developing breast cancer. The main innovation behind this methodology lies in the use of deep learning models for the problem of jointly classifying unregistered mammogram views and respective segmentation maps of breast lesions (i.e. Read More

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https://ieeexplore.ieee.org/document/8032490/
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http://dx.doi.org/10.1109/TMI.2017.2751523DOI Listing
November 2017
5 Reads

Can magnetic resonance imaging obviate the need for biopsy for microcalcifications?

Gland Surg 2017 Aug;6(4):302-307

Department of Breast Surgery, Yokohama Rosai Hospital, Yokohama 222-0036, Japan.

Background: Although microcalcifications detected with mammography (MG) are usually biopsied, biopsies cannot be performed in all cases. We sought to determine if magnetic resonance imaging (MRI) findings could indicate whether stereotactic vacuum-assisted biopsy (SVAB) is necessary.

Methods: Patients with mammographically detected Breast Imaging-Reporting and Data System (BI-RADS) 3, 4, and 5 microcalcifications were analyzed from April 2012 to September 2014. Read More

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http://dx.doi.org/10.21037/gs.2017.03.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5566654PMC
August 2017
4 Reads

Improving image quality for digital breast tomosynthesis: an automated detection and diffusion-based method for metal artifact reduction.

Phys Med Biol 2017 Sep 15;62(19):7765-7783. Epub 2017 Sep 15.

In digital breast tomosynthesis (DBT), the high-attenuation metallic clips marking a previous biopsy site in the breast cause errors in the estimation of attenuation along the ray paths intersecting the markers during reconstruction, which result in interplane and inplane artifacts obscuring the visibility of subtle lesions. We proposed a new metal artifact reduction (MAR) method to improve image quality. Our method uses automatic detection and segmentation to generate a marker location map for each projection (PV). Read More

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http://dx.doi.org/10.1088/1361-6560/aa8803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735824PMC
September 2017
16 Reads

Adjunctive Breast-Specific Gamma Imaging for Detecting Cancer in Women with Calcifications at Mammography.

Ann Surg Oncol 2017 Nov 17;24(12):3541-3548. Epub 2017 Aug 17.

Department of Nuclear Medicine, Seoul Medical Center, Seoul, Korea.

Background: Mammography detects calcium deposits sensitively, but the specificity for differentiating malignancy from benign calcifications is low. Thus, we investigated whether adjunctive breast-specific gamma imaging (BSGI) has incremental value for detecting cancer in women with suspicious calcifications detected by mammography, and compared BSGI with adjunctive ultrasonography (US).

Methods: The medical records of women without a personal history of breast cancer who underwent mammography for breast evaluation from 2009 to 2014 were reviewed retrospectively. Read More

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http://dx.doi.org/10.1245/s10434-017-6058-1DOI Listing
November 2017
26 Reads

Association of BRCA Mutation Types, Imaging Features, and Pathologic Findings in Patients With Breast Cancer With BRCA1 and BRCA2 Mutations.

AJR Am J Roentgenol 2017 Oct 10;209(4):920-928. Epub 2017 Aug 10.

2 Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43 gil, Songpa-gu, Seoul 05505, Korea.

Objective: The purpose of this study is to retrospectively evaluate the relationships between the BRCA mutation types, imaging features, and pathologic findings of breast cancers in BRCA1 and BRCA2 mutation carriers.

Materials And Methods: We identified patients with breast cancer with BRCA gene mutations from January 2000 to December 2014. After excluding patients who underwent lesion excision before MRI, 99 BRCA1 and 103 BRCA2 lesions in 187 women (mean age, 39. Read More

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http://dx.doi.org/10.2214/AJR.16.16957DOI Listing
October 2017
9 Reads

Potential Use of American College of Radiology BI-RADS Mammography Atlas for Reporting and Assessing Lesions Detected on Dedicated Breast CT Imaging: Preliminary Study.

Acad Radiol 2017 11 17;24(11):1395-1401. Epub 2017 Jul 17.

Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.

Rationale And Objectives: Dedicated breast computed tomography (DBCT) is an emerging and promising modality for breast lesions. The objective of this study was to evaluate the potential use of applying the BI-RADS Mammography Atlas 5th Edition for reporting and assessing breast lesions on DBCT. Currently, no atlas exists for DBCT. Read More

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http://dx.doi.org/10.1016/j.acra.2017.06.003DOI Listing
November 2017
69 Reads

Relationships between pathology and crystal structure in breast calcifications: an X-ray diffraction study in histological sections.

NPJ Breast Cancer 2016 14;2:16029. Epub 2016 Sep 14.

Cranfield Forensic Institute, Cranfield University, Cranfield, UK.

Calcifications are not only one of the most important early diagnostic markers of breast cancer, but are also increasingly believed to aggravate the proliferation of cancer cells and invasion of surrounding tissue. Moreover, this influence appears to vary with calcification composition. Despite this, remarkably little is known about the composition and crystal structure of the most common type of breast calcifications, and how this differs between benign and malignant lesions. Read More

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http://www.nature.com/articles/npjbcancer201629
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http://dx.doi.org/10.1038/npjbcancer.2016.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515336PMC
September 2016
5 Reads

BI-RADS Category 3 Comparison: Probably Benign Category after Recall from Screening before and after Implementation of Digital Breast Tomosynthesis.

Radiology 2017 12 17;285(3):778-787. Epub 2017 Jul 17.

From the Department of Radiology, Breast Imaging Section, University of Pennsylvania, Perelman School of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce St, 1 Silverstein, Philadelphia, PA 19104-4283 (E.S.M., S.P.W., M.D.S., E.F.C.); and General Medicine Division, Massachusetts General Hospital, Harvard Medical School, Boston, Mass (A.M.M.).

Purpose To evaluate Breast Imaging Reporting and Data System (BI-RADS) category 3 assessment at diagnostic examination after recall from screening in a large urban population after implementation of digital breast tomosynthesis (DBT) by focusing both on overall use and use stratified by recalled finding type and outcome at 2 years. Materials and Methods This was an intuitional review board-approved and HIPAA-compliant retrospective review of 10 728 digital mammography (DM) examinations from September 1, 2010, to August 30, 2011, and 15 571 screening DBT examinations from October 1, 2011, to February 28, 2013. The recall populations for DM and DBT were 1112 of 10 728 (10. Read More

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http://dx.doi.org/10.1148/radiol.2017162837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5708302PMC
December 2017
19 Reads

High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy.

J Biophotonics 2018 01 21;11(1). Epub 2017 Jun 21.

School of Physics and Astronomy, University of Exeter, Streatham Campus, EX4 4QL, Exeter, UK.

The aim of this research was to develop a novel approach to probe non-invasively the composition of inorganic chemicals buried deep in large volume biological samples. The method is based on advanced Transmission Raman Spectroscopy (TRS) permitting chemical specific detection within a large sampling volume. The approach could be beneficial to chemical identification of the breast calcifications detected during mammographic X-ray procedures. Read More

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http://dx.doi.org/10.1002/jbio.201600260DOI Listing
January 2018
15 Reads

Breast metastases from extramammary malignancies: multimodality imaging aspects.

Br J Radiol 2017 Aug 25;90(1077):20170197. Epub 2017 May 25.

1 Department of Imaging, AC Camargo Cancer Center, São Paulo, São Paulo, Brazil.

Breast metastases from extramammary cancers are rare and usually related to poor prognosis. The extramammary tumours most frequently exhibiting breast metastases are melanoma, lymphomas, ovarian cancer, lung and neuroendocrine tumours, and sarcomas. Owing to the lack of reliable and specific clinical or radiological signs for the diagnosis of breast metastases, a combination of techniques is needed to differentiate these lesions from primary breast carcinoma or even benign breast lesions. Read More

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http://dx.doi.org/10.1259/bjr.20170197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5858809PMC
August 2017
36 Reads

[Imaging diagnostics of breast metastases from extramammary tumors].

Radiologe 2017 Jun;57(6):459-465

Institut für Diagnostische und Interventionelle Radiologie, Universität Leipzig, Leipzig, Deutschland.

Breast metastases of solid extramammary tumors are very rare in comparison to primary malignancies of the breast and account for only 0.33-6.3% of all malignant neoplasms of the breast. Read More

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http://dx.doi.org/10.1007/s00117-017-0247-6DOI Listing
June 2017
6 Reads

Breast Tomosynthesis: Practical Considerations.

Radiol Clin North Am 2017 May 23;55(3):493-502. Epub 2017 Feb 23.

Department of Radiology, Lynn Sage Comprehensive Breast Center, Prentice Women's Hospital, Feinberg School of Medicine, Northwestern University, 250 East Superior Street, Room 4-2304, Chicago, IL 60611, USA. Electronic address:

Digital breast tomosynthesis (DBT) is rapidly becoming the new standard of care for breast cancer screening. DBT has improved on the limitations of traditional digital mammography by increasing cancer detection and decreasing false-positive examinations. Interpretation of DBT is slightly different than digital mammography and therefore experience with the technology is paramount to achieve best performance. Read More

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http://dx.doi.org/10.1016/j.rcl.2016.12.004DOI Listing
May 2017
4 Reads

Sclerosing adenosis: Ultrasonographic and mammographic findings and correlation with histopathology.

Mol Clin Oncol 2017 Feb 13;6(2):157-162. Epub 2016 Dec 13.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China; Department of Diagnostic Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.

The present study was conducted to evaluate the radiological findings, particularly the ultrasonographic (US) characteristics of sclerosing adenosis (SA), and their correlation with histopathological results. A retrospective review identified 191 patients with a total of 200 lesions histopathologically confirmed as SA following breast surgery between July 2009 and December 2012. Of the 191 patients, 145 (151 lesions) with SA as the major component were included for US and mammographic (MG) analysis. Read More

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http://dx.doi.org/10.3892/mco.2016.1108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351743PMC
February 2017
12 Reads

Investigating the feasibility of classifying breast microcalcifications using photon-counting spectral mammography: A simulation study.

Med Phys 2017 Jun 20;44(6):2304-2311. Epub 2017 Apr 20.

Office of Science and Engineering Laboratories, CDRH, U.S. Food and Drug Administration, Silver Spring, MD, 20993-0002, USA.

Purpose: A dual-energy material decomposition method using photon-counting spectral mammography was investigated as a non-invasive diagnostic approach to differentiate between Type I calcifications, consisting of calcium oxalate dihydrate or weddellite compounds that are more often associated with benign lesions, and Type II calcifications containing hydroxyapatite that are predominantly associated with malignant tumors.

Methods: The study was carried out by numerical simulation to assess the feasibility of the proposed approach. A pencil-beam geometry was modeled, and the total number of x-rays transported through a breast embedded with microcalcifications of different types and sizes were simulated by a one-pixel detector. Read More

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http://dx.doi.org/10.1002/mp.12230DOI Listing
June 2017
7 Reads

Breast lipoma with central fat necrosis: case report.

Pan Afr Med J 2016 13;25:235. Epub 2016 Dec 13.

Department of Radiology, University Hospital Mohammed VI of Marrakesh, Morocco.

Fat necrosis of the breast is a benign non-suppurative inflammatory process of adipose tissue that most commonly occurs as the result of minor breast trauma. We present a case of a 40-years-old female with fat necrosis in a breast lipoma. She presented with an overlapping mass on the lateral quadrants. Read More

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http://dx.doi.org/10.11604/pamj.2016.25.235.10935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337265PMC
March 2017
6 Reads

Elemental vs. phase composition of breast calcifications.

Sci Rep 2017 03 9;7(1):136. Epub 2017 Mar 9.

Cranfield Forensic Institute, Cranfield University, Shrivenham, UK.

Despite the importance of calcifications in early detection of breast cancer, and their suggested role in modulating breast cancer cell behaviour, very little detail is known about their chemical composition or how this relates to pathology. We measured the elemental composition of calcifications contained within histological sections of breast tissue biopsies, and related this to both crystallographic parameters measured previously in the same specimens, and to the histopathology report. The Ca:P ratio is of particular interest since this theoretically has potential as a non-invasive aid to diagnosis; this was found to lie in a narrow range similar to bone, with no significant difference between benign and malignant. Read More

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http://www.nature.com/articles/s41598-017-00183-y
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http://dx.doi.org/10.1038/s41598-017-00183-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5427875PMC
March 2017
4 Reads

Shear wave elastography in the diagnosis of breast non-mass lesions: factors associated with false negative and false positive results.

Eur Radiol 2017 Sep 6;27(9):3788-3798. Epub 2017 Feb 6.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50, Ilwon-Dong, Gangnam-Gu, Seoul, 135-710, Korea.

Objective: To investigate factors related to false shear wave elastography (SWE) results for breast non-mass lesions (NMLs) detected by B-mode US.

Methods: This retrospective study enrolled 152 NMLs detected by B-mode US and later pathologically confirmed (79 malignant, 73 benign). All lesions underwent B-mode US and SWE. Read More

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http://dx.doi.org/10.1007/s00330-017-4763-6DOI Listing
September 2017
3 Reads

Non-mass breast lesions on ultrasound: final outcomes and predictors of malignancy.

Acta Radiol 2017 Sep 23;58(9):1054-1060. Epub 2017 Jan 23.

1 Department of Diagnostic Radiology, CHA Bundang Medical Center, CHA University, Gyunggi-do, Republic of Korea.

Background Breast cancer can present as non-mass lesions (NMLs) on ultrasound. However, knowledge of and understanding about NMLs are scarce. Purpose To retrospectively investigate the final outcomes of sonographic breast NMLs and determine the clinical and radiologic variables associated with malignancy Material and Methods In our radiologic database of breast ultrasound examinations between 2011 and 2014, we found 119 women with 121 NMLs with available histopathologic or sonographic follow-up (over 2 years) data. Read More

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http://dx.doi.org/10.1177/0284185116683574DOI Listing
September 2017
6 Reads

Contemporary indications for diagnostic open biopsy in women assessed for screen-detected breast lesions: A ten-year, single institution series of 814 consecutive cases.

Breast Cancer Res Treat 2017 02 6;162(1):49-58. Epub 2017 Jan 6.

BreastScreen SA and the Department of Surgery, University of Adelaide, Adelaide, SA, Australia.

Purpose: In contemporary practice, 5% of women with non-malignant needle biopsies of screen-detected lesions still require diagnostic open biopsy (OBx). Our aims are to (i) capture a snapshot of the contemporary indications for OBx in screen-detected lesions; (ii) determine upgrade rates to malignancy (DCIS or invasive cancer); (iii) identify indications with sufficiently low upgrades to justify avoidance of OBx and (iv) propose plausible non-surgical alternatives.

Methods: Between Jan 2005 and Dec 2014, women assessed for a screen-detected lesion and recommended for OBx are included. Read More

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http://dx.doi.org/10.1007/s10549-016-4087-2DOI Listing
February 2017
4 Reads

Do Calcifications Seen on Mammography After Neoadjuvant Chemotherapy for Breast Cancer Always Need to Be Excised?

Ann Surg Oncol 2017 Jun 5;24(6):1492-1498. Epub 2017 Jan 5.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: This study aimed to determine the relationship between mammographic calcifications and magnetic resonance imaging (MRI) tumoral enhancement before and after neoadjuvant chemotherapy (NAC) and to assess the impact of these findings on surgical management.

Methods: This Institutional Review Board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant retrospective study involved breast cancer patients who underwent NAC between 2009 and 2015. The study cohort comprised 90 patients with pre- and posttreatment MRI and mammograms demonstrating calcifications within the tumor bed either at presentation or after treatment. Read More

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http://dx.doi.org/10.1245/s10434-016-5741-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5485840PMC
June 2017
4 Reads

Increased Malignant Microcalcifications after Neoadjuvant Chemotherapy in Advanced Breast Cancer.

J Breast Cancer 2016 Dec 23;19(4):459-464. Epub 2016 Dec 23.

Department of Nuclear Medicine, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

In patients with advanced breast cancer, most new calcifications detected on a mammogram after neoadjuvant chemotherapy are benign dystrophic calcifications, but this is not always observed. We present a patient with advanced breast cancer who had paradoxically increased malignant microcalcifications concomitant with primary tumor regression after undergoing neoadjuvant chemotherapy. After the neoadjuvant chemotherapy, the follow-up mammogram revealed that local, fine pleomorphic microcalcifications had markedly increased. Read More

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http://dx.doi.org/10.4048/jbc.2016.19.4.459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204054PMC
December 2016
9 Reads

Addition of Digital Breast Tomosynthesis to Full-Field Digital Mammography in the Diagnostic Setting: Additional Value and Cancer Detectability.

J Breast Cancer 2016 Dec 23;19(4):438-446. Epub 2016 Dec 23.

Department of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to assess the value of adding digital breast tomosynthesis (DBT) to full-field digital mammography (FFDM) in the diagnostic workup of breast cancer and to determine which lesion variables affect cancer detectability in the combined modality.

Methods: Between March and May 2012, paired FFDM and DBT images were obtained from 203 women as part of a diagnostic workup for breast cancer. Images from FFDM alone, DBT alone, and DBT combined with FFDM were reviewed in separate sessions by six blinded readers. Read More

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http://dx.doi.org/10.4048/jbc.2016.19.4.438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204051PMC
December 2016
9 Reads