510,787 results match your criteria Breast Anatomy


Co-effects of C/Ag dual ion implantation on enhancing antibacterial ability and biocompatibility of silicone rubber.

Biomed Mater 2020 Jun 5. Epub 2020 Jun 5.

Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Army Medical University, Xinqiao Road, Sha Ping Ba District, Chongqing, 400037, People's Republic of China., Chongqing, 400038, CHINA.

Although silicone implants are the most popular choice around the world for breast augmentation, reconstruction, and revision, due to the poor antibacterial properties and limited biocompatibility of silicone rubber (SR), one of the major complications, capsule contracture, is a lingering problem. To overcome the two main shortcomings, dual ion implantation technique was applied to modify the surface of SR with the basic skeleton element of organic matters, carbon (C) and the broad-spectrum bactericide, silver (Ag). We present surface characterization, toxicological effects, and evaluation of the mechanical, antibacterial and biocompatible properties of C and Ag co-implanted SR (C/Ag-SRs). Read More

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http://dx.doi.org/10.1088/1748-605X/ab99d3DOI Listing

What the HEC? Clinician Adherence to Evidence-Based Antiemetic Prophylaxis for Highly Emetogenic Chemotherapy.

J Natl Compr Canc Netw 2020 Jun;18(6):676-681

8University of Alabama at Birmingham, Birmingham, Alabama.

Background: Clinician adherence to antiemetic guidelines for preventing chemotherapy-induced nausea and vomiting (CINV) caused by highly emetogenic chemotherapy (HEC) remains poorly characterized. The primary aim of this study was to evaluate individual clinician adherence to HEC antiemetic guidelines.

Patients And Methods: A retrospective analysis of patients receiving HEC was conducted using the IBM Watson Explorys Electronic Health Record Database (2012-2018). Read More

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http://dx.doi.org/10.6004/jnccn.2019.7526DOI Listing

Serial Assessment of Urinary Incontinence in Breast Cancer Survivors Undergoing (Neo)Adjuvant Therapy.

J Natl Compr Canc Netw 2020 Jun;18(6):712-716

3Department of Medical Oncology, City of Hope National Medical Center, Duarte, California.

Background: Among breast cancer survivors, urinary incontinence (UI) is often attributed to cancer therapy. We prospectively assessed urinary symptoms before and after (neo)adjuvant treatment of early-stage breast cancer.

Methods: With consent, women with stage I-III breast cancer completed the Urogenital Distress Inventory and the Incontinence Impact Questionnaire before and 3 months after initiating (neo)adjuvant therapy. Read More

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http://dx.doi.org/10.6004/jnccn.2020.7535DOI Listing

The EndoPredict score predicts response to neoadjuvant chemotherapy and neoendocrine therapy in hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer patients from the ABCSG-34 trial.

Eur J Cancer 2020 Jun 2;134:99-106. Epub 2020 Jun 2.

Institute of Cancer Research, Department of Medicine I, Breast Health Center and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

Background: Neoadjuvant chemotherapy (NaCT) and neoadjuvant endocrine therapy (NET) can reduce pre-operative tumour burden in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative early-stage breast cancer. This prospective translational study assessed the ability of a 12-gene molecular score (MS; EndoPredict®) to predict response to NaCT or NET within the ABCSG-34 trial.

Patients And Methods: Hormone receptor (HR)-positive, HER2-negative samples from patients in the ABCSG-34 randomized phase II trial were selected and EndoPredict testing was performed to generate a 12-gene MS. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.020DOI Listing

Changes in breast cancer management during the Corona Virus Disease 19 pandemic: An international survey of the European Breast Cancer Research Association of Surgical Trialists (EUBREAST).

Breast 2020 May 29;52:110-115. Epub 2020 May 29.

Department of Radiation Oncology, Iridium Kankernetwerk, Wilrijk-Antwerp, Belgium; Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk-Antwerp, Belgium.

Background: Corona Virus Disease 19 (COVID-19) had a worldwide negative impact on healthcare systems, which were not used to coping with such pandemic. Adaptation strategies prioritizing COVID-19 patients included triage of patients and reduction or re-allocation of other services. The aim of our survey was to provide a real time international snapshot of modifications of breast cancer management during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1016/j.breast.2020.05.006DOI Listing

Erector spinae plane block for postoperative analgesia in breast and thoracic surgery: A systematic review and meta-analysis.

J Clin Anesth 2020 Jun 2;66:109900. Epub 2020 Jun 2.

Department of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Study Objective: The erector spinae plane block (ESPB) is a newly defined regional anesthesia technique first introduced in 2016. The aim of this study is to determine its analgesic efficacy compared with non-block care and thoracic paravertebral block (TPVB).

Design: We systematically searched PubMed, Web of Science citation index, Embase, the Cochrane Library, Google Scholar, and ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.jclinane.2020.109900DOI Listing

Predictive factors of major deviation (>20 mm) between lesion sizes measured by magnetic resonance imaging and histology for invasive lobular breast cancer.

Eur J Obstet Gynecol Reprod Biol 2020 May 19;251:14-19. Epub 2020 May 19.

Department of Gynaecology, CHRU de Tours, Tours, France; François Rabelais University, Tours, France; INSERM, Tours, France. Electronic address:

Objective: To identify factors predictive of high discordance (>20 mm) between lesion sizes measured by magnetic resonance imaging (MRI) and histology for invasive lobular breast cancer.

Materials And Methods: Data for all women with invasive lobular breast cancer (pure or associated with a component of invasive ductal carcinoma) between 1st January 2007 and 31st December 2016 were included in this study. Logistic regression analysis was performed to determine factors predictive of high discordance (underestimation/overestimation by >20 mm) between tumour sizes measured by MRI and histology for invasive lobular breast cancer. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.036DOI Listing

An Invited Commentary on "Reducing the negative appendectomy rate with the laparoscopic appendicitis score: a multicenter prospective cohort and validation study" (Int J Surg 2020; Epub ahead of print).

Int J Surg 2020 Jun 2. Epub 2020 Jun 2.

Department of Anorectal Surgery, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, 201203, Shanghai, China; Anorectal Disease Institute of Shuguang Hospital, 201203, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ijsu.2020.05.068DOI Listing

Src couples estrogen receptor to the anticipatory unfolded protein response and regulates cancer cell fate under stress.

Biochim Biophys Acta Mol Cell Res 2020 Jun 2:118765. Epub 2020 Jun 2.

Department of Biochemistry, University of Illinois, Urbana, IL, USA; Cancer Center at Illinois, University of Illinois, Urbana, IL, USA. Electronic address:

Accumulation of unfolded protein, or other stresses, activates the classical reactive unfolded protein response (UPR). In the recently characterized anticipatory UPR, receptor-bound estrogen, progesterone and other mitogenic hormones rapidly elicit phosphorylation of phospholipase C γ (PLCγ), activating the anticipatory UPR. How estrogen and progesterone activating their receptors couples to PLCγ phosphorylation and anticipatory UPR activation was unknown. Read More

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http://dx.doi.org/10.1016/j.bbamcr.2020.118765DOI Listing

Supervised Learning Occurs in Visual Perceptual Learning of Complex Natural Images.

Curr Biol 2020 Jun 2. Epub 2020 Jun 2.

Brown University, Department of Cognitive, Linguistic, and Psychological Sciences, 190 Thayer Street, Providence, RI 02912, USA. Electronic address:

There have been long-standing debates regarding whether supervised or unsupervised learning mechanisms are involved in visual perceptual learning (VPL) [1-14]. However, these debates have been based on the effects of simple feedback only about response accuracy in detection or discrimination tasks of low-level visual features such as orientation [15-22]. Here, we examined whether the content of response feedback plays a critical role for the acquisition and long-term retention of VPL of complex natural images. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.050DOI Listing

Dual-Probe Approach for Mass Spectrometric Quantification of MUC1-Specific Terminal Gal/GalNAc .

Anal Chem 2020 Jun 5. Epub 2020 Jun 5.

Nanjing Medical University, School of Pharmacy, Nanjing, 211166, China.

Protein glycosylation is a prevalent post-translational modification that mediates a variety of cellular processes. For membrane proteins, glycosylation at their terminal motif is usually more functional. Among the various glycosylation types found in membrane proteins, O-glycosylation is the most common and is closely correlated with a variety of cancer types, including breast cancer. Read More

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http://dx.doi.org/10.1021/acs.analchem.0c00807DOI Listing

Faecal calprotectin levels during the first year of life in healthy children.

J Paediatr Child Health 2020 Jun 5. Epub 2020 Jun 5.

Division of Social Paediatrics, Department of Paediatrics, İstanbul Medical Faculty, İstanbul University, İstanbul, Turkey.

Aim: A high faecal calprotectin (FC) level is a non-invasive marker for inflammatory bowel disease. Nevertheless, healthy infants have elevated levels of FC with large variations. The aim of our study was to determine the levels of FC and associated factors in healthy infants aged 0-12 months. Read More

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http://dx.doi.org/10.1111/jpc.14933DOI Listing

Adjuvant chemotherapy for breast cancer after preoperative chemotherapy: A propensity score matched analysis.

PLoS One 2020 5;15(6):e0234173. Epub 2020 Jun 5.

Department of Surgery, Institut Curie, Paris, France.

Although identified to be at a higher risk of relapse, no consensus exists on the treatment of breast cancer (BC) patients with no pathological complete response after neoadjuvant chemotherapy (NAC). The benefit of adjuvant chemotherapy (ADJ) in this context has scarcely been studied. We evaluated the benefit of administrating adjuvant chemotherapy in a real life cohort of BC patients with invasive residual disease after NAC. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234173PLOS

In-hospital Outcomes of Left Ventricular Assist Devices (LVAD) Patients Undergoing Noncardiac Surgery.

ASAIO J 2020 Jun 4. Epub 2020 Jun 4.

From the Division of Cardiovascular Diseases, Section of Heart Failure and Transplant, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

An increasing number of stage D heart failure patients are supported with left ventricular assist devices (LVADs), and the management of LVAD patients who require noncardiac surgery (NCS) presents unique challenges. Using the 2010-2014 National Inpatient Sample, we identified all adult cases of LVAD patients undergoing noncardiac surgeries using ICD-9-CM codes. We estimated inpatient mortality, bleeding complications, stroke, length of stay (LOS), and cost of hospitalization of the admissions related to NCS using mixed effects logistic and linear mixed regressions, respectively. Read More

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http://dx.doi.org/10.1097/MAT.0000000000001205DOI Listing

miR-623 suppresses cell proliferation, migration and invasion through direct inhibition of XRCC5 in breast cancer.

Aging (Albany NY) 2020 Jun 5;12. Epub 2020 Jun 5.

Department of General Surgery, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan 250000, Shandong, P.R.China.

Background/aims: MicroRNAs (miRNAs) are short, non-coding RNA molecules that control gene expression trough negative translational regulation. MiR-623 is a tumor suppressor, and it's function and mechanism in breast cancer has not been reported.

Results: Exogenous overexpression of miR-623 suppressed cell proliferation, migration and invasion, meanwhile, but promoted cell apoptosis. Read More

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http://dx.doi.org/10.18632/aging.103182DOI Listing

A review of the PERFORMS scheme in breast screening.

Br J Radiol 2020 Jun 5:20190908. Epub 2020 Jun 5.

Division of Cancer and Stem Cells, University of Nottingham, Nottingham, UK.

This review details the aetiology of the PERFORMS self-assessment scheme in breast screening, together with its subsequent development, current implementation and future function. The purpose of the scheme is examined and the importance of its continuing role in a changing screening service described, together with current evolution. Read More

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http://dx.doi.org/10.1259/bjr.20190908DOI Listing

Progress in the research of p53 tumour suppressor activity controlled by Numb in triple-negative breast cancer.

J Cell Mol Med 2020 Jun 5. Epub 2020 Jun 5.

School of Basic Medical Sciences, Medical University of Chongqing, Chongqing, China.

Numb is known as a cell fate determinant as it identifies the direction of cell differentiation via asymmetrical partitioning during mitosis. It is considered as a tumour suppressor, and a frequent loss of Numb expression in breast cancer is noted. Numb forms a tri-complex with p53 and E3 ubiquitin ligase HDM2 (also known as MDM2), thereby preventing the ubiquitination and degradation of p53. Read More

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http://dx.doi.org/10.1111/jcmm.15366DOI Listing

Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression.

Glycobiology 2020 May 30. Epub 2020 May 30.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dundee, DD1 5EH, United Kingdom.

Siglec-15 is a conserved sialic acid-binding Ig-like lectin expressed on osteoclast progenitors that plays an important role in osteoclast development and function. It is also expressed by tumor-associated macrophages and by some tumors, where it is thought to contribute to the immunosuppressive microenvironment. It was shown previously that engagement of macrophage-expressed Siglec-15 with tumor cells expressing its ligand, sialyl Tn (sTn), triggered production of TGF-β. Read More

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http://dx.doi.org/10.1093/glycob/cwaa048DOI Listing

Modelling biological age based on plasma peptides in Han Chinese adults.

Aging (Albany NY) 2020 Jun 5;12. Epub 2020 Jun 5.

Department of Epidemiology and Health Statistics, School of Public Health, Beijing Key Laboratory of Clinical Epidemiology, Capital Medical University, Beijing 100069, China.

Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mass spectrometry, 84 peptides were detected with masses in the range of 0. Read More

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http://dx.doi.org/10.18632/aging.103286DOI Listing

Opioid rotation from transdermal fentanyl to continuous subcutaneous hydromorphone in a cachectic patient: A case report and review of the literature.

J Oncol Pharm Pract 2020 Jun 5:1078155220929415. Epub 2020 Jun 5.

Division of Family & Community Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Opioid rotation from transdermal fentanyl to an alternate opioid is often necessitated in advanced disease, but is fraught with uncertainty due to variable absorption from the patch in end-stage illness and the lack of a clearly established opioid rotation ratio. The manufacturer of transdermal fentanyl provides opioid rotation recommendations only for rotation from the oral morphine equivalent daily dose (MEDD) of opioid to the patch, not in the opposite direction. This is a case report of a single patient with cancer and cachexia admitted to the palliative care unit of a large academic medical centre in Canada. Read More

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http://dx.doi.org/10.1177/1078155220929415DOI Listing

Classification of breast masses on ultrasound shear wave elastography using convolutional neural networks.

Ultrason Imaging 2020 Jun 5:161734620932609. Epub 2020 Jun 5.

Department of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo, Japan.

We aimed to use deep learning with convolutional neural networks (CNNs) to discriminate images of benign and malignant breast masses on ultrasound shear wave elastography (SWE). We retrospectively gathered 158 images of benign masses and 146 images of malignant masses as training data for SWE. A deep learning model was constructed using several CNN architectures (Xception, InceptionV3, InceptionResNetV2, DenseNet121, DenseNet169, and NASNetMobile) with 50, 100, and 200 epochs. Read More

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http://dx.doi.org/10.1177/0161734620932609DOI Listing

Nanoparticle albumin-bound paclitaxel/liposomal-encapsulated doxorubicin in HER2-negative metastatic breast cancer patients.

Future Oncol 2020 Jun 5. Epub 2020 Jun 5.

Medical Oncology 1, Regina Elena National Cancer Institute, IRCCS, Rome, Italy.

To investigate the toxicity of nab-paclitaxel (wNP)/nonpegylated liposome-encapsulated doxorubicin (wNPLD) combination in HER2-negative metastatic breast cancer (MBC) patients as first-line treatment. Phase I, single-arm study in metastatic breast cancer patients naive to previous chemotherapy for advanced disease. A 3 + 3 dose-escalation design was used to determine the safety. Read More

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http://dx.doi.org/10.2217/fon-2019-0742DOI Listing

Circulating tumour cells as prognosis predictive markers of neoadjuvant chemotherapy-treated breast cancer patients.

J Chemother 2020 Jun 5:1-6. Epub 2020 Jun 5.

Zhong Yuan Academy of Biological Medicine, Liaocheng People's Hospital, Liaocheng, Shandong, P. R. China.

In this study, we detected and measured the count of circulating tumour cells (CTCs) in breast cancer (BC) patients who were treated by neoadjuvant chemotherapy (NAC) in order to assess the clinical validity of CTCs. A total of 96 patients with locally advanced BC and who were treated by NAC were enrolled in this study. The CTC count in the peripheral blood was estimated by negative enrichment-fluorescence hybridization before and after NAC. Read More

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http://dx.doi.org/10.1080/1120009X.2020.1774207DOI Listing

What Is the Burden of Care of Nasoalveolar Molding?

Cleft Palate Craniofac J 2020 Jun 5:1055665620929224. Epub 2020 Jun 5.

Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, USA.

Objective: This systematic review aims to evaluate nasoalveolar molding (NAM) in the context of burden of care defined as physical, psychosocial, or financial burden on caregivers.

Search Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 5 databases were searched from inception through December 24, 2019, for keywords and subject headings pertaining to cleft lip and/or palate and NAM.

Eligibility Criteria: Clinical studies on NAM with reference to physical (access to care, number of visits, distance traveled), psychosocial (caregiver perceptions, family interactions, breast milk feeding), and financial (direct and indirect costs) burden were included. Read More

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http://dx.doi.org/10.1177/1055665620929224DOI Listing

Exploring the Role of Social Support in Promoting Patient Participation in Health Care among Women with Breast Cancer.

Health Commun 2020 Jun 5:1-9. Epub 2020 Jun 5.

Department of Industrial and Systems Engineering and Center for Health Enhancement Systems Studies, University of Wisconsin-Madison.

Scholars have adopted Street's (2003) ecological model of communication in medical encounters to investigate the factors promoting patient participation in health care. However, factors demonstrated in the ecological model were bounded in the context of medical care primarily focusing on health care providers and patients. Social factors, such as patients' relationships and supportive communication with others the context of health care remain relatively unexplored. Read More

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http://dx.doi.org/10.1080/10410236.2020.1773704DOI Listing

Is GSH Chelated Pt Molecule Inactive in Anti-Cancer Treatment? A Case Study of Pt GS.

Small 2020 Jun 5:e2002044. Epub 2020 Jun 5.

Department of Chemistry and Chemical Engineering, Beijing University of Technology, Beijing, 100124, P. R. China.

Platinum (Pt) drugs are widely used in anti-cancer treatment although many reports advocated that tumor cells could inactivate Pt drugs via glutathione-Pt (GSH-Pt) adducts formation. To date, GSH chelated Pt molecules have not been assessed in cancer treatment because GSH-Pt adducts are not capable of killing cancer cells, which is widely accepted and well followed. In this report, endogenous biothiol is utilized to precisely synthesize a GSH chelated Pt molecule (Pt GS ). Read More

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http://dx.doi.org/10.1002/smll.202002044DOI Listing

Non-invasive lobular neoplasia of the breast: Morphologic features, clinical presentation, and management dilemmas.

Breast J 2020 Jun 4. Epub 2020 Jun 4.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

The designation of noninvasive lobular neoplasia applies to atypical epithelial proliferations composed of noncohesive cells secondary to loss or functional alteration of E-cadherin-mediated cell adhesion. The morphologic spectrum of noninvasive lobular neoplasia encompasses atypical lobular hyperplasia (ALH) and classic lobular carcinoma in situ (classic LCIS) and two LCIS variants, namely florid LCIS (F-LCIS) and pleomorphic LCIS (P-LCIS), as defined in the World Health Organization (WHO) Classification of Tumors of the Breast 5th ed. Herein, we review the morphologic, immunohistochemical, and molecular features of noninvasive lobular neoplasia, with special emphasis on F-LCIS and P-LCIS. Read More

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http://dx.doi.org/10.1111/tbj.13857DOI Listing

Metabolic syndrome and early stage breast cancer outcome: results from a prospective observational study.

Breast Cancer Res Treat 2020 Jun 4. Epub 2020 Jun 4.

Department of Clinical Medicine and Surgery, Oncology Division, University of Naples Federico II, Naples, Italy.

Purpose: Obesity and insulin resistance have been associated with poor prognosis in breast cancer (BC). The present prospective study aimed to investigate the impact of metabolic syndrome (MetS) and its components on early BC (eBC) patients' outcome.

Methods: MetS was defined by the presence of 3 to 5 of the following components: waist circumference > 88 cm, blood pressure ≥ 130/≥ 85 mmHg, serum levels of triglycerides ≥ 150 mg/dL, high density lipoprotein < 50 mg/dL and fasting glucose ≥ 110 mg/dL. Read More

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http://dx.doi.org/10.1007/s10549-020-05701-7DOI Listing

Adoption of SSO-ASTRO Margin Guidelines for Ductal Carcinoma in Situ: What Is the Impact on Use of Additional Surgery?

Ann Surg Oncol 2020 Jun 4. Epub 2020 Jun 4.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Historically, more than one-third of patients with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery (BCS) underwent additional surgery. The SSO-ASTRO guidelines advise 2 mm margins for patients with DCIS having BCS and whole-breast radiation (WBRT). Here we examine guideline impact on additional surgery and factors associated with re-excision. Read More

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http://dx.doi.org/10.1245/s10434-020-08610-7DOI Listing

ASO Author Reflections: Axillary Staging in Node-Positive Breast Cancer Patients Treated with Neoadjuvant Chemotherapy-Beyond Clinical Trials.

Ann Surg Oncol 2020 Jun 4. Epub 2020 Jun 4.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1245/s10434-020-08693-2DOI Listing

The Nipple Split Sharing vs. Conventional Nipple Graft Technique in Chest Wall Masculinization Surgery: Can We Improve Patient Satisfaction and Aesthetic Outcomes?

Aesthetic Plast Surg 2020 Jun 4. Epub 2020 Jun 4.

Division of Plastic and Reconstructive Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Double incision mastectomy with free nipple grafts (DIFNG) offers more flexible nipple-areola complex (NAC) resizing and repositioning in transmale and gender non-conforming individuals. The cis-male NAC has a smaller diameter, oval shape and lateral position. If nipple grafts are performed without having these considerations, aesthetics can be dissatisfying. Read More

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http://dx.doi.org/10.1007/s00266-020-01803-1DOI Listing

FCGCNMDA: predicting miRNA-disease associations by applying fully connected graph convolutional networks.

Mol Genet Genomics 2020 Jun 4. Epub 2020 Jun 4.

School of Information and Electrical Engineering, Xuzhou University of Technology, Xuzhou, 221018, China.

Growing evidence indicates that the development and progression of multiple complex diseases are influenced by microRNA (miRNA). Identifying more miRNAs as biomarkers for clinical diagnosis, treatment and prognosis is vital to promote the development of bioinformatics and medicine. Considering that the traditional biological experimental methods are generally time-consuming and expensive, high-efficient computational methods are encouraged to uncover potential disease-related miRNAs. Read More

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http://dx.doi.org/10.1007/s00438-020-01693-7DOI Listing

A three-dimensional computed tomography angiography study of the anatomy of the accessory middle colic artery and implications for colorectal cancer surgery.

Surg Radiol Anat 2020 Jun 4. Epub 2020 Jun 4.

Department of Gastroenterological, General, Breast and Thyroid Surgery, Faculty of Medicine, Yamagata University, Yamagata, 990-9585, Japan.

Purpose: In the present study, we focused on the accessory middle colic artery and aimed to increase the safety and curative value of colorectal cancer surgery by investigating the artery course and branching patterns.

Methods: We included 143 cases (mean age, 70.4 ± 11. Read More

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http://dx.doi.org/10.1007/s00276-020-02511-wDOI Listing

Identification of a group with high risk of postoperative complications after deep bowel endometriosis surgery: a retrospective study on 164 patients.

Arch Gynecol Obstet 2020 Jun 4. Epub 2020 Jun 4.

Department of General and Gynecological Surgery, University Hospital Center (CHU)-Rangueil, 1 Avenue du Professeur Jean Poulhès, 31400, Toulouse, France.

Purpose: Identify a group with a high risk of postoperative complications after deep bowel endometriosis surgery.

Methods: We conducted a retrospective study on patients treated from 2012 to 2018 in two departments of gynecological surgery at the Toulouse University Hospital, France. The postoperative complications were evaluated in relation to the surgical management, associated with or without non-digestive surgical procedures, initial disease and patient's characteristics. Read More

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http://dx.doi.org/10.1007/s00404-020-05604-4DOI Listing

GLUT1 participates in tamoxifen resistance in breast cancer cells through autophagy regulation.

Naunyn Schmiedebergs Arch Pharmacol 2020 Jun 5. Epub 2020 Jun 5.

Department of Medical Oncology, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, Heilongjiang, 150081, People's Republic of China.

Tamoxifen is an estrogen modulator widely used in the treatment of patients with ESR/ER-positive breast cancer; however, resistance limits its clinical application. Autophagy alterations have recently been suggested as a new mechanism for tamoxifen resistance. Glucose transporter 1 (GLUT1) has been reported to be associated with the development and metastasis of breast cancer, but the relationship among GLUT1, autophagy, and endocrine resistance remains unclear. Read More

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http://dx.doi.org/10.1007/s00210-020-01893-3DOI Listing

Correlation of contrast-enhanced ultrasound features with prognostic factors in invasive ductal carcinomas of the breast.

Jpn J Radiol 2020 Jun 4. Epub 2020 Jun 4.

Department of Ultrasonics, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.

Objectives: To correlate contrast-enhanced ultrasound (CEUS) features with pathological prognostic factors of breast invasive ductal carcinomas (IDCs).

Methods: 169 patients who were admitted to our hospital with confirmed IDCs diagnosed between August 2017 and June 2019 were selected. CEUS indicators included the time of contrast agent entered the lesion, the degree of enhancement, the boundary of the lesion, whether there was perfusion defect and nourishing blood vessels, and etc. Read More

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http://dx.doi.org/10.1007/s11604-020-00994-6DOI Listing

An Ultrasensitive Routine LC-MS/MS Method for Estradiol and Estrone in the Clinically Relevant Sub-Picomolar Range.

J Endocr Soc 2020 Jun 21;4(6):bvaa047. Epub 2020 Apr 21.

Hormone Laboratory, Haukeland University Hospital, Bergen, Norway.

Background: Current analytical routine methods lack the sensitivity to monitor plasma estrogen levels in breast cancer patients treated with aromatase inhibitors. Such monitoring is warranted for premenopausal patients treated with an aromatase inhibitor and an LH-releasing hormone analogue in particular. Therefore, we aimed to develop a routine tandem mass spectroscopy combined with liquid chromatography (LC-MS/MS) method for estradiol (E2) and estrone (E1) for use in the sub-picomolar range. Read More

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http://dx.doi.org/10.1210/jendso/bvaa047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252770PMC

microRNA-Dependent Modulation of Genes Contributes to ESR1's Effect on ERα Positive Breast Cancer.

Front Oncol 2020 15;10:753. Epub 2020 May 15.

Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Dysregulation of ESR1 accounts for endocrine therapy resistance and metastasis of ERα positive breast cancer. However, the underlying molecular mechanism of ESR1 in ERα positive breast cancer remains insufficiency. Notably, to date, a comprehensive miRNA-mRNA regulatory network involved in modulation of ESR1 in development and progression of ERα positive breast cancer is still not established. Read More

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http://dx.doi.org/10.3389/fonc.2020.00753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243797PMC

Insulin Growth Factor Binding Protein 7 (IGFBP7)-Related Cancer and IGFBP3 and IGFBP7 Crosstalk.

Front Oncol 2020 15;10:727. Epub 2020 May 15.

Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada.

The insulin/insulin-like growth factors (IGFs) have crucial tasks in the growth, differentiation, and proliferation of healthy and pernicious cells. They are involved in coordinated complexes, including receptors, ligands, binding proteins, and proteases. However, the systems can become dysregulated in tumorigenesis. Read More

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http://dx.doi.org/10.3389/fonc.2020.00727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242731PMC

Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment.

Front Oncol 2020 15;10:553. Epub 2020 May 15.

Morgridge Institute for Research, Madison, WI, United States.

New tools are needed to match cancer patients with effective treatments. Patient-derived organoids offer a high-throughput platform to personalize treatments and discover novel therapies. Currently, methods to evaluate drug response in organoids are limited because they overlook cellular heterogeneity. Read More

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http://dx.doi.org/10.3389/fonc.2020.00553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242740PMC

Retrospective Analysis of HER2+ Breast Cancer Outcomes at a County Hospital: Do Published Outcomes Hold up in the Real World?

Cureus 2020 May 2;12(5):e7937. Epub 2020 May 2.

Hematology & Oncology, Olive View - University of California Los Angeles (UCLA) Medical Center, Los Angeles, USA.

Introduction: Landmark trials repeatedly demonstrate that pertuzumab and trastuzumab plus standard chemotherapy have the best outcomes in human epidermal growth factor receptor 2 (HER2) positive breast cancer in the neoadjuvant, adjuvant, and metastatic setting. However, many of these multicenter landmark trials lack diversity and studied largely Caucasian populations. Our goal is to address this under-representation of minorities, and compare pathologic complete response (pCR) rates in our predominantly Hispanic population with HER2 positive breast cancer receiving the same neoadjuvant chemotherapy (NACT) at Olive View-UCLA Medical Center (OVMC) to that of pCR rates observed in the TRYPHAENA trial. Read More

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http://dx.doi.org/10.7759/cureus.7937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266367PMC

Optimal breast cancer diagnostic strategy using combined ultrasound and diffuse optical tomography.

Biomed Opt Express 2020 May 24;11(5):2722-2737. Epub 2020 Apr 24.

Biomedical Engineering Department, Washington University in St. Louis, 1 Brooking Dr, St. Louis, MO 63130, USA.

Ultrasound (US)-guided near-infrared diffuse optical tomography (DOT) has demonstrated great potential as an adjunct breast cancer diagnosis tool to US imaging alone, especially in reducing unnecessary benign biopsies. However, DOT data processing and image reconstruction speeds remain slow compared to the real-time speed of US. Real-time or near real-time diagnosis with DOT is an important step toward the clinical translation of US-guided DOT. Read More

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http://dx.doi.org/10.1364/BOE.389275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249842PMC

Intraoperative tumor margin assessment using diffuse reflectance spectroscopy: the effect of electrosurgery on tissue discrimination using ex vivo animal tissue models.

Biomed Opt Express 2020 May 7;11(5):2402-2415. Epub 2020 Apr 7.

Delft University of Technology, Biomechanical Engineering Department, Delft, The Netherlands.

Using an intraoperative margin assessment technique during breast-conserving surgery (BCS) helps surgeons to decrease the risk of positive margin occurrence. Diffuse reflectance spectroscopy (DRS) has the potential to discriminate healthy breast tissue from cancerous tissue. We investigated the performance of an electrosurgical knife integrated with a DRS on porcine muscle and adipose tissue. Read More

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http://dx.doi.org/10.1364/BOE.385621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249845PMC

Utility of regional nodal irradiation in Japanese patients with breast cancer with 1-3 positive nodes after breast-conserving surgery and axillary lymph-node dissection.

Mol Clin Oncol 2020 Jul 18;13(1):48-53. Epub 2020 May 18.

Department of Breast Oncology, Aichi Cancer Centre, Nagoya, Aichi 464-8681, Japan.

The utility of regional nodal irradiation (RNI) is being considered in cases of 1-3 axillary node metastases after breast-conserving surgery (BCS) with axillary lymph-node dissection (ALND). Therefore, we examined the necessity of RNI by examining the sites of recurrences in cases at our institution. We retrospectively analyzed 5,164 cases of primary breast cancer between January 2000 and December 2014 at the Aichi Cancer Centre, identifying local and distant recurrences in 152 patients with primary breast cancer treated with BCS and ALND and who had 1-3 positive axillary nodes. Read More

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http://dx.doi.org/10.3892/mco.2020.2046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265225PMC

Investigation of the association between metabolic syndrome and breast cancer patients.

Eur J Transl Myol 2020 Apr 1;30(1):8776. Epub 2020 Apr 1.

Department of Internal Medicine, School of Medicine, Hazrat-e Rasool Hospital, Iran University of Medical Sciences. Tehran, Iran.

One of the most serious cancers among women is breast cancer. This disease is the first reason for the death of women due to cancer. Increasing breast cancer risk may associate with many factors including genetic, reproductive factors, people's lifestyle, metabolic syndrome (MS) and hormones. Read More

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http://dx.doi.org/10.4081/ejtm.2019.8776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254422PMC

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation.

Oncotarget 2020 May 19;11(20):1862-1875. Epub 2020 May 19.

TRON-Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

PLAC1 (placenta enriched 1) is a mammalian trophoblast-specific protein. Aberrant expression of PLAC1 is observed in various human cancers, where it is involved in the motility, migration, and invasion of tumor cells, which are associated with the phosphoinositide 3-kinase (PI3K)/AKT pathway. We previously demonstrated that AKT activation mediates the downstream effects of PLAC1; however, the molecular mechanisms of PLAC1-induced AKT-mediated tumor-related processes are unclear. Read More

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http://dx.doi.org/10.18632/oncotarget.27582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244013PMC

Erysipelas on surgical scar: a case report.

Pan Afr Med J 2020 7;35:30. Epub 2020 Feb 7.

Department of Gynecology and Obstetrics at the University Hospital of Monastir, Monastir, Tunisia.

Erysipelas is a non-necrotizing acute dermal hypodermatitis most often of streptococcal origin. It most often affects the lower limbs. Erysipelas on surgical scar has been rarely reported in the literature. Read More

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http://dx.doi.org/10.11604/pamj.2020.35.30.17551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245975PMC
February 2020

aberrations increase the risk of brain metastases and predict poor prognosis in metastatic breast cancer patients.

Ther Adv Med Oncol 2020 11;12:1758835920915305. Epub 2020 May 11.

Department of Breast Cancer Medical Oncology, Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xiangya Medical School, Central South University, No. 283, Tongzipo Road, Changsha, 410013, P.R. China.

Background: The survival status of patients with breast cancer and brain metastasis (BCBM) receiving current treatments is poor.

Method: We designed a real-world study to investigate using patients' clinical and genetic aberrations to forecast the prognoses of BCBM patients. We recruited 146 BCBM patients and analyzed their clinical features to evaluate the overall survival (OS). Read More

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http://dx.doi.org/10.1177/1758835920915305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243401PMC

CircRNA_103809 Suppresses the Proliferation and Metastasis of Breast Cancer Cells by Sponging MicroRNA-532-3p (miR-532-3p).

Front Genet 2020 15;11:485. Epub 2020 May 15.

Department of Breast, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Breast cancer has become one of the most serious disease threatening mankind health in the world. Accumulating studies indicated that circRNAs played an important role in the occurrence and progression of breast cancer, however, the roles of circRNA_103809 in breast cancer progression remain unclear. Therefore, in this study, we aimed to clarify the potential role and regulatory mechanism of circRNA_103809 in the development of breast cancer. Read More

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http://dx.doi.org/10.3389/fgene.2020.00485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243809PMC
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