471,029 results match your criteria Breast Anatomy


Elevated serum HER-2 predicts poor prognosis in breast cancer and is correlated to ADAM10 expression.

Cancer Med 2019 Jan 19. Epub 2019 Jan 19.

Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China.

Human epidermal growth factor receptor-2 (HER-2) overexpression in breast tumor tissues is associated with a poor prognosis but may benefit from treatment with trastuzumab. The extracellular domain (ECD) of HER-2 can be measured in serum and which has been a new inspection item in clinical laboratory of several hospitals. However, whether serum HER-2 ECD can be a marker of HER-2 status in tumor tissues still confused clinicians. Read More

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http://dx.doi.org/10.1002/cam4.1859DOI Listing
January 2019

Updated breast CT dose coefficients (DgN ) using patient-derived breast shapes and heterogenous fibroglandular distributions.

Med Phys 2019 Jan 19. Epub 2019 Jan 19.

Department of Radiology, University of California Davis, Sacramento, CA, 95817.

Purpose: The purpose of this work was to generate uncompressed heterogenous breast phantom models using size-dependent fibroglandular distributions derived from a large cohort of breast CT (bCT) data sets, and to compare differences in normalized glandular dose coefficients for bCT "DgN " when the realistic heterogenous model is considered relative to the simple, homogenous model used in the past.

Methods: A cohort of 274 segmented bCT data sets were used to quantify the fibroglandular tissue distribution within the breast parenchyma. Each data set was interpolated to an isotropic voxel size of 0. Read More

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http://dx.doi.org/10.1002/mp.13391DOI Listing
January 2019

Multi-domain features for reducing false positives in automated detection of clustered microcalcifications in digital breast tomosynthesis.

Med Phys 2019 Jan 19. Epub 2019 Jan 19.

Department of Medical Imaging, , Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.

Purpose: In digital breast tomosynthesis (DBT) imaging, a microcalcification (MC) cluster may span across different slices and blurring exists in the out-of-focus slices. We developed a radiomics approach to extract features from focus slice and combine multiple spatial domains to reduce false positives (FPs) in an automated pipeline of detecting MC clusters.

Methods: We performed a retrospective study on a cohort of 290 Chinese women patients with a total of 580 DBT volumes. Read More

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http://dx.doi.org/10.1002/mp.13394DOI Listing
January 2019

Development and Testing of a Decision Aid for Unaffected Women with a BRCA1 or BRCA2 Mutation.

J Cancer Educ 2019 Jan 19. Epub 2019 Jan 19.

The Phyllis F. Cantor Center for Research in Nursing and Patient Care Services, Dana Farber Cancer Institute, 375 Longwood Ave., Boston, MA, 02215, USA.

For women who are unaffected carriers of a pathogenic BRCA mutation, cancer risk management requires ongoing education, counseling, and support from an interdisciplinary team of medical specialists, genetic counselors, and nurses specializing in genomics. The purpose of this study was to develop and pilot test an educational, patient-focused decision aid to facilitate shared decision making. A steering committee developed the prototype aid after an extensive review of the literature. Read More

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http://dx.doi.org/10.1007/s13187-019-1470-9DOI Listing
January 2019

Effect of peptide-conjugated nanoparticles on cell lines.

Prog Biomater 2019 Jan 19. Epub 2019 Jan 19.

Department of Chemistry, KSOU, Manasagangothri, Mysore, Karnataka, 570006, India.

Metal nanoparticles are widely used for the delivery and targeting of pharmaceutical, therapeutic and diagnostic agents in cancer therapy in recent years. The multifunctional nanoparticles constructed currently are supposed to show superior effects on cancer cells. This study was conducted to observe the difference between the effect of a biologically important peptide, silver (AgNPs) and gold (AuNPs) nanoparticles and their conjugates on two different cancer cells. Read More

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http://dx.doi.org/10.1007/s40204-019-0106-9DOI Listing
January 2019

Bag-1 silencing enhanced chemotherapeutic drug-induced apoptosis in MCF-7 breast cancer cells affecting PI3K/Akt/mTOR and MAPK signaling pathways.

Mol Biol Rep 2019 Jan 19. Epub 2019 Jan 19.

Department of Molecular Biology and Genetics, Istanbul Kultur University, Istanbul, Turkey.

The multifunctional anti-apoptotic Bag-1 protein has important roles in apoptosis, proteasome-mediated degradation, transcriptional regulation, and intracellular signaling. Bag-1 promotes cell survival and proliferation, and is overexpressed in breast cancer. Therefore, Bag-1-targeted therapy might be a promising strategy to treat breast cancer. Read More

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http://dx.doi.org/10.1007/s11033-018-4540-xDOI Listing
January 2019

Characterization of GH2 and GH42 β-galactosidases derived from bifidobacterial infant isolates.

AMB Express 2019 Jan 19;9(1). Epub 2019 Jan 19.

APC Microbiome Ireland, University College Cork, Western Road, Cork, Ireland.

Bifidobacteria are among the first and most abundant bacterial colonizers of the gastrointestinal tract of (breast-fed) healthy infants. Their success of colonising the infant gut is believed to be, at least partly, due to their ability to metabolize available carbon sources by means of secreted or intracellular glycosyl hydrolases (GHs). Among these, β-galactosidases are particularly relevant as they allow bifidobacteria to grow on β-galactosyl-linked saccharidic substrates, which are present in copious amounts in the milk-based diet of their infant host (e. Read More

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http://dx.doi.org/10.1186/s13568-019-0735-3DOI Listing
January 2019

Cancers Preceding Parkinson's Disease after Adjustment for Bias in a Danish Population-Based Case-Control Study.

Neuroepidemiology 2019 Jan 18;52(3-4):136-143. Epub 2019 Jan 18.

Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles (UCLA), Los Angeles, California,

Cancer patients are at lower risk of developing Parkinson's disease (PD) compared with the general population. One explanation is the negative association between smoking and PD, but PD risk is also lower for cancers not related to smoking. Another explanation is survival bias where death from cancer may act as a competing risk. Read More

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http://dx.doi.org/10.1159/000494292DOI Listing
January 2019

External beam accelerated partial breast irradiation: dosimetric assessment of conformal and three different intensity modulated techniques.

Radiol Oncol 2019 Jan 19. Epub 2019 Jan 19.

Center of Radiotherapy, National Institute of Oncology, Budapest, Hungary.

Background The aim of the study was to evaluate and compare four different external beam radiotherapy techniques of accelerated partial breast irradiation (APBI) considering target coverage, dose to organs at risk and overall plan quality. The investigated techniques were three dimensional conformal radiotherapy (3D-CRT), "step and shoot" (SS) and "sliding window" (SW) intensity-modulated radiotherapy (IMRT), intensity-modulated arc therapy (RA). Patients and methods CT scans of 40 APBI patients were selected for the study. Read More

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http://dx.doi.org/10.2478/raon-2019-0001DOI Listing
January 2019

Phytochemical analysis, cytotoxic and antioxidant activities of Myrtus communis essential oil from Morocco.

J Complement Integr Med 2019 Jan 19. Epub 2019 Jan 19.

Experimental Oncology and Natural Substances Team, Cellular and Molecular Immuno-pharmacology, Faculty of Science and Technology, Sultan Moulay Slimane University, Beni-Mellal, Morocco.

Background Myrtus communis L. is an aromatic evergreen plant common in Morocco. In addition to its culinary uses, it has been used medicinally as a disinfectant, an antiseptic or as a hypoglycemic agent. Read More

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http://www.degruyter.com/view/j/jcim.ahead-of-print/jcim-201
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http://dx.doi.org/10.1515/jcim-2018-0100DOI Listing
January 2019
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Clinical spectrum and pleiotropic nature of germline mutations.

J Med Genet 2019 Jan 19. Epub 2019 Jan 19.

Epithelial Interactions in Cancer Department, Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal.

encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is involved in major cellular processes such as embryogenesis and maintenance of tissue architecture, it is no surprise that deleterious effects arise from its loss of function. E-cadherin is recognised as a tumour suppressor gene, and it is well established that genetic alterations cause diffuse gastric cancer and lobular breast cancer-the foremost manifestations of the hereditary diffuse gastric cancer syndrome. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105807DOI Listing
January 2019

Rad51/BRCA2 disruptors inhibit homologous recombination and synergize with olaparib in pancreatic cancer cells.

Eur J Med Chem 2019 Jan 10;165:80-92. Epub 2019 Jan 10.

Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy; Computational & Chemical Biology, Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova, Italy. Electronic address:

Olaparib is a PARP inhibitor (PARPi). For patients bearing BRCA1 or BRCA2 mutations, olaparib is approved to treat ovarian cancer and in clinical trials to treat breast and pancreatic cancers. In BRCA2-defective patients, PARPi inhibits DNA single-strand break repair, while BRCA2 mutations hamper double-strand break repair. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.008DOI Listing
January 2019

Personality and preventive healthcare utilisation: Evidence from the IRISH Longitudinal Study on Ageing.

Prev Med 2019 Jan 17. Epub 2019 Jan 17.

Health Economics, University of Birmingham, Birmingham, UK.

There is extensive empirical evidence that personality is associated with many outcomes and behaviours, such as educational outcomes, labour market participation, savings behaviour, health behaviours, physical health status and mortality. Use of preventive healthcare services (e.g. Read More

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http://dx.doi.org/10.1016/j.ypmed.2018.12.029DOI Listing
January 2019

Oxysterols and nuclear receptors.

Mol Cell Endocrinol 2019 Jan 17. Epub 2019 Jan 17.

Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, United States; University of Illinois Cancer Center, Chicago, IL, United States; Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, United States; Carl R. Woese Institute for Genomic Biology, Anticancer Discovery from Pets to People Theme, University of Illinois at Urbana Champaign, Urbana, IL, United States; Cancer Center at Illinois, University of Illinois at Urbana-Champaign, IL, United States. Electronic address:

Oxysterols are derivatives of cholesterol and an important regulator of cholesterol metabolism, in part due to their role as ligands for nuclear receptors, such as the liver x receptors. Oxysterols are also known to be ligands for the RAR-related orphan receptors, involved in normal T cell differentiation. However, increasing evidence supports a role for oxysterols in the progression of several diseases. Read More

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http://dx.doi.org/10.1016/j.mce.2019.01.016DOI Listing
January 2019

Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active targeting to breast cancer.

Eur J Pharm Biopharm 2019 Jan 17. Epub 2019 Jan 17.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. Electronic address:

An ideal cancer therapy targets the tumor cells selectively without damaging healthy tissues. Even though the tumor-specific markers are limited, these molecules can be used for the delivery of anti-cancer drugs as an active targeting strategy. Since the lymphatic system plays a critical role in the dissemination of cancer cells, the drugs directed through lymphatics can feasibly reach to the sites of metastasis. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.01.017DOI Listing
January 2019

Melosuavine I, an apoptosis-inducing bisindole alkaloid from Melodinus suaveolens.

Fitoterapia 2019 Jan 17. Epub 2019 Jan 17.

School of Biological Sciences and Technology, University of Jinan, Jinan 250022, PR China. Electronic address:

A new bisindole alkaloid, melosuavine I (1) possessing an aspidosperma- aspidosperma dimeric skeleton, was isolated from the leaves of Melodinus suaveolens. The structure with absolute configuration of 1 was elucidated by a combination of MS, NMR and computational methods. MTT assays indicated that 1 exhibited significant cytotoxicity on human breast cancer BT549 cells with an IC value of 0. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0367326X183220
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http://dx.doi.org/10.1016/j.fitote.2018.12.026DOI Listing
January 2019
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The anti-malarial drug artesunate causes cell cycle arrest and apoptosis of triple-negative MDA-MB-468 and HER2-enriched SK-BR-3 breast cancer cells.

Exp Mol Pathol 2019 Jan 17. Epub 2019 Jan 17.

Department of Pathology, Dalhousie University, Halifax, Canada; Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada; Department of Surgery, Dalhousie University, Halifax, Canada. Electronic address:

Breast cancer is the most prevalent cancer diagnosis in women, with triple-negative and human epidermal growth factor 2 (HER2)-enriched advanced breast cancers having the poorest prognoses. The morbidity and mortality associated with advanced disease, as well as the emergence of multi-drug resistant variants, highlights the urgency to develop novel therapeutic agents. Artesunate (ART) is a semi-synthetic derivative of artemisinin from the Chinese herb sweet wormwood. Read More

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http://dx.doi.org/10.1016/j.yexmp.2019.01.006DOI Listing
January 2019

Natural history, treatment, and long-term follow up of patients with multiple endocrine neoplasia type 2B: an international, multicentre, retrospective study.

Lancet Diabetes Endocrinol 2019 Jan 16. Epub 2019 Jan 16.

Endocrine Oncology, Institut Gustave Roussy Ecole Doctorale de Cancerologie, Villejuif, France.

Background: Multiple endocrine neoplasia type 2B is a rare syndrome caused mainly by Met918Thr germline RET mutation, and characterised by medullary thyroid carcinoma, phaeochromocytoma, and extra-endocrine features. Data are scarce on the natural history of multiple endocrine neoplasia type 2B. We aimed to advance understanding of the phenotype and natural history of multiple endocrine neoplasia type 2B, to increase awareness and improve detection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183033
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http://dx.doi.org/10.1016/S2213-8587(18)30336-XDOI Listing
January 2019
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Acetonitrile-assisted enzymatic digestion can facilitate the bottom-up identification of proteins of cancer origin.

Anal Biochem 2019 Jan 17. Epub 2019 Jan 17.

Institute of Analytical Chemistry of the Czech Academy of Sciences, Veveří 97, 602 00, Brno, Czech Republic. Electronic address:

The main objective of this study was to develop an effective in-gel trypsin digestion protocol using aqueous-acetonitrile solvent system to facilitate MS analysis and maximize the number of identified proteins from biological samples. The procedure, where 80% acetonitrile was present in the trypsin reaction mixture, increased the number of matched peptides, and allowed the identification of more proteins with higher coverage than the common digestion protocol. Vimentin, annexins, tubulin, actin, peptidyl-prolyl cis-trans isomerase or alpha-enolase are examples of important proteins that change during the progress cancer. Read More

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http://dx.doi.org/10.1016/j.ab.2019.01.004DOI Listing
January 2019

The anticancer properties and mechanism of action of tablysin-15, the RGD-containing disintegrin, in breast cancer cells.

Int J Biol Macromol 2019 Jan 17. Epub 2019 Jan 17.

Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address:

αβ integrin expressed on cancer cell surfaces is associated with important cancer hallmarks including survival and metastasis and is thus a potential anticancer drug target. Tablysin-15 contains the RGD motif and is a high-affinity αβ integrin antagonist. The aim of this study was to investigate the antitumor effect and mechanism of action of tablysin-15 against αβ integrin high-expressing breast cancer cell lines in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.073DOI Listing
January 2019

Thinking Outside the Heart.

Authors:
Jessica M Peña

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Dalio Institute of Cardiovascular Imaging, Weill Cornell Medical College and NewYork-Presbyterian Hospital, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jcmg.2018.08.041DOI Listing
January 2019

Perspectives on geriatric oncology research presented at the 2018 San Antonio Breast Cancer Symposium.

J Geriatr Oncol 2019 Jan 16. Epub 2019 Jan 16.

Department of Geriatrics, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga 15, Belisario Domínguez Sección XVI, 14080 Tlalpan, CDMX, Mexico City, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.jgo.2019.01.002DOI Listing
January 2019

Systematic Review of the Effect of Topical Application of Human Breast Milk on Early Umbilical Cord Separation.

J Obstet Gynecol Neonatal Nurs 2019 Jan 17. Epub 2019 Jan 17.

Objective: To evaluate the efficacy of topical application of human breast milk to reduce umbilical cord separation time.

Data Sources: We used a three-step search strategy. First, we searched six electronic databases from inception through July 16, 2018: PubMed, Cochrane, CINAHL, Embase, Scopus, and ProQuest Dissertations and Theses Global. Read More

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http://dx.doi.org/10.1016/j.jogn.2018.12.004DOI Listing
January 2019

Initial Clinical Experience with Stationary Digital Breast Tomosynthesis.

Acad Radiol 2019 Jan 16. Epub 2019 Jan 16.

Department of Physics and Astronomy, University of North Carolina at Chapel Hill,Chapel Hill, North Carolina.

Rationale And Objectives: A linear array of carbon nanotube-enabled x-ray sources allows for stationary digital breast tomosynthesis (sDBT), during which projection views are collected without the need to move the x-ray tube. This work presents our initial clinical experience with a first-generation sDBT device.

Materials And Methods: Following informed consent, women with a "suspicious abnormality" (Breast Imaging Reporting and Data System 4), discovered by digital mammography and awaiting biopsy, were also imaged by the first generation sDBT. Read More

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http://dx.doi.org/10.1016/j.acra.2018.12.026DOI Listing
January 2019

[Level of exposure to fluorides by the consumption of different types of milk in residents from an area of Mexico with endemic hydrofluorosis].

An Pediatr (Barc) 2019 Jan 16. Epub 2019 Jan 16.

División de Ciencias Naturales y Exactas, Campus Guanajuato, Universidad de Guanajuato, Guanajuato, México. Electronic address:

Introduction: Several studies have shown the presence of fluorosis (DF) in primary dentition, suggesting an exposure to fluorides (F) in early childhood. Breast milk is recommended as an exclusive food until 6 months of age. Although it is mentioned that only a small amount of F can be eliminated by breast milk, studies have shown the presence of this element in milk of women living in contaminated areas, as well as in infant formulas. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.10.005DOI Listing
January 2019

Effect of Lavender Oil on the Anxiety of Patients Before Breast Surgery.

J Perianesth Nurs 2019 Jan 16. Epub 2019 Jan 16.

Purpose: Anxiety is a common problem before surgery. This study aimed to investigate the effects of inhaling lavender oil on anxiety levels in patients before breast surgery.

Design: A randomized controlled design was used. Read More

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http://dx.doi.org/10.1016/j.jopan.2018.10.002DOI Listing
January 2019

Combining hydrophilic chemotherapy and hydrophobic phytotherapy via tumor-targeted albumin-QDs nano-hybrids: covalent coupling and phospholipid complexation approaches.

J Nanobiotechnology 2019 Jan 19;17(1). Epub 2019 Jan 19.

Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.

Background: The rationale of this study is to combine the merits of both albumin nanoparticles and quantum dots (QDs) in improved drug tumor accumulation and strong fluorescence imaging capability into one carrier. However, premature drug release from protein nanoparticles and high toxicity of QDs due to heavy metal leakage are among challenging hurdles. Following this platform, we developed cancer nano-theranostics by coupling biocompatible albumin backbone to CdTe QDs and mannose moieties to enhance tumor targeting and reduce QDs toxicity. Read More

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http://dx.doi.org/10.1186/s12951-019-0445-7DOI Listing
January 2019

Nonrigid reconstruction of 3D breast surfaces with a low-cost RGBD camera for surgical planning and aesthetic evaluation.

Med Image Anal 2019 Jan 11;53:11-25. Epub 2019 Jan 11.

Wellcome / EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London, UK. Electronic address:

Accounting for 26% of all new cancer cases worldwide, breast cancer remains the most common form of cancer in women. Although early breast cancer has a favourable long-term prognosis, roughly a third of patients suffer from a suboptimal aesthetic outcome despite breast conserving cancer treatment. Clinical-quality 3D modelling of the breast surface therefore assumes an increasingly important role in advancing treatment planning, prediction and evaluation of breast cosmesis. Read More

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http://dx.doi.org/10.1016/j.media.2019.01.003DOI Listing
January 2019

The associations between left-hand digit ratio (2D:4D) and puberty characteristics among Chinese girls.

Early Hum Dev 2019 Jan 15;130:22-26. Epub 2019 Jan 15.

Department of Child and Adolescent Health, School of Public Health, Bengbu Medical College, Bengbu, China. Electronic address:

Background: The aim of this study was to analyse the associations of left-hand digit ratio (2D:4D), digit length and puberty characteristics to show the role of prenatal hormones in development among Chinese girls.

Method: A total of 318 Chinese girls aged 8-15 years were recruited using a stratified cluster sampling method. The index finger (2D), ring finger (4D) of the left hand, oestradiol and testosterone were measured, and age at menarche (AAM), breast (high and low) and pubic hair (high and low) development were recorded. Read More

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http://dx.doi.org/10.1016/j.earlhumdev.2019.01.007DOI Listing
January 2019

Targeting EGFR of triple-negative breast cancer enhances the therapeutic efficacy of paclitaxel- and cetuximab-conjugated nanodiamond nanocomposite.

Acta Biomater 2019 Jan 16. Epub 2019 Jan 16.

Department and Institute of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan; Institute of Molecular Medicine and Bioengineering, National Chiao Tung University, Hsinchu 30068, Taiwan; Center For Intelligent Drug Systems and Smart Bio-devices, National Chiao Tung University, Hsinchu 30068, Taiwan. Electronic address:

Breast cancer is the most common malignancy and a leading cause of cancer-related mortality among women worldwide. Triple-negativebreastcancer (TNBC) is characterized by the lack of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER2). However, epidermal growth factor receptor (EGFR) is highly expressed in most of the TNBCs, which may provide a potential target for EGFR targeting therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193004
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http://dx.doi.org/10.1016/j.actbio.2019.01.025DOI Listing
January 2019
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ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women.

Reprod Toxicol 2019 Jan 16. Epub 2019 Jan 16.

Department of Natural Products and Toxicology, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, Brazil. Electronic address:

Nifedipine, a known substrate to breast cancer resistance protein (ABCG2/BCRP), is used for the treatment of hypertension during breastfeeding. This study aimed to evaluate the effect of ABCG2 c.421C > A on nifedipine transfer to breast milk (BM) in hypertensive women. Read More

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http://dx.doi.org/10.1016/j.reprotox.2019.01.007DOI Listing
January 2019

Associations between cervical, breast and colorectal cancer screening uptake, chronic diseases and health-related behaviours: Data from the Italian PASSI nationwide surveillance.

Prev Med 2019 Jan 16. Epub 2019 Jan 16.

Epidemiology Unit, AUSL of Reggio Emilia-IRCCS, via Amendola, 2, 42122 Reggio Emilia, Italy. Electronic address:

Screening programmes have been proposed as a privileged setting for health promotion interventions. We aim to assess the associations between behavioural risk factors, chronic conditions and diseases and cervical, breast and colorectal cancer screening uptake. Secondly, we aim to assess whether these associations are due to underlying differences in socioeconomic characteristics. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.01.007DOI Listing
January 2019

Seven new guanacastane-type diterpenoids from the fungus Verticillium dahliae.

Fitoterapia 2019 Jan 16. Epub 2019 Jan 16.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University; Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, Wenhua Road 103, Shenyang 110016, China. Electronic address:

Seven new guanacastane-type diterpenoids, namely dahlianes E-K (1-7), and three known ones (8-10) were isolated from the cultures of the fungus Verticillium dahliae. Their structures were established by extensive spectroscopic data analysis along with Rh(OCOCF)- and Mo(OAc)-induced electronic circular dichroism (ECD) experiment. Dahliane G showed an 80-fold potentiation effect on the sensitization of doxorubicin at the concentration of 15 μM when screening the reversal activity on doxorubicin-resistant human breast cancer cells (MCF-7/DOX). Read More

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http://dx.doi.org/10.1016/j.fitote.2019.01.009DOI Listing
January 2019

MODELING MALIGNANCIES USING INDUCED PLURIPOTENT STEM CELLS: FROM CHRONIC MYELOID LEUKEMIA (CML) TO HEREDITARY CANCERS.

Exp Hematol 2019 Jan 16. Epub 2019 Jan 16.

INSERM UMR-S 935, Université Paris Sud, 94800 Villejuif, France and ESTeam Paris Sud, Université Paris Sud, 94800 Villejuif, France; INGESTEM National iPSC Infrastructure, 94800 Villejuif, France.

During the last decade, the possibility of reprogramming malignant cells to a pluripotent state has been achieved in several hematological malignancies, including myeloproliferative neoplasms, myelodysplastic syndromes and chronic myeloid leukemia (CML). It has been shown that it is readily possible to generate iPSC from several types of primary CML cells and generate progenitors and differentiated cells with variable efficiency. Although these experiments have brought some new insights in the understanding of CML pathophysiology, the ultimate goal of generating induced leukemic stem cells (LSC) with long-term multilineage potential has not yet been demonstrated. Read More

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http://dx.doi.org/10.1016/j.exphem.2019.01.003DOI Listing
January 2019

Insights into how phosphorylation of estrogen receptor at serine 305 modulates tamoxifen activity in breast cancer.

Mol Cell Endocrinol 2019 Jan 16. Epub 2019 Jan 16.

Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL, USA.

Estrogen receptor (ER) is the most important factor in the pathophysiology of breast cancer. Consequently, modulation of ER activity has been exploited to develop drugs against ER + breast cancer, such as tamoxifen, referred to as endocrine therapies. With deeper understanding of ER mechanism of action, posttranslational modifications (PTMs) are increasingly recognized as important in mediating ER activity. Read More

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http://dx.doi.org/10.1016/j.mce.2019.01.014DOI Listing
January 2019

Phytochemical profiling, Antioxidant and Anticancer activities of Gastrocotyle hispida growing in Saudi Arabia.

Acta Trop 2019 Jan 16. Epub 2019 Jan 16.

Chemistry Department, Cape Peninsula University of Technology, P.O. Box 1906, Bellville 7535, South Africa.

The present study aimed at isolation the phytocompounds from the aerial parts of Gastrocotyle hispida and to evaluate its antioxidant and anticancer potential using in vitro assay. Gastrocotyle hispida is belonging to the family Boraginaceae used as a refreshing drink like tea. The decoction of the leaves is diuretic and is used in the treatment of rheumatism. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183015
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http://dx.doi.org/10.1016/j.actatropica.2019.01.013DOI Listing
January 2019
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Radiation dermatitis with foreign body reaction clinically mimics a cutaneous metastasis from breast cancer.

Breast J 2019 Jan;25(1):141-142

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/tbj.13176DOI Listing
January 2019

Extended adjuvant therapy for early-stage breast cancer: Are there markers for its use?

Breast J 2019 Jan;25(1):7-8

Magee-Women's Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1111/tbj.13038DOI Listing
January 2019

Contrast-enhanced MRI for breast cancer screening.

J Magn Reson Imaging 2019 Jan 18. Epub 2019 Jan 18.

Center for Advanced Imaging Innovation and Research / Department of Radiology, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, New York, USA.

Multiple studies in the first decade of the 21 century have established contrast-enhanced breast MRI as a screening modality for women with a hereditary or familial increased risk for the development of breast cancer. In recent studies, in women with various risk profiles, the sensitivity ranges between 81% and 100%, which is approximately twice as high as the sensitivity of mammography. The specificity increases in follow-up rounds to around 97%, with positive predictive values for biopsy in the same range as for mammography. Read More

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http://dx.doi.org/10.1002/jmri.26654DOI Listing
January 2019

18F-Deoxyglucose (18F-FDG) Positron Emission Tomography/Computed Tomography (PET/CT) Monitoring of Dynamic Growth Characteristics of Walker-256 Tumor Models in 3 Different Locations in Rats.

Med Sci Monit 2019 Jan 19;25:558-564. Epub 2019 Jan 19.

Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (mainland).

BACKGROUND We explored the ideal method of establishing subcutaneous, breast, and liver tumor models using the same Walker-256 cells, and investigated the dynamic growth characteristics using ¹⁸F-deoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT), which provides basic information for choosing an experimental animal model. MATERIAL AND METHODS We established tumor models in 3 locations (subcutaneous, breast, and liver) in W256 Sprague-Dawley rats. ¹⁸F-FDG PET/CT imaging was performed from 6 days to 18 days after injecting the cells subcutaneously. Read More

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https://www.medscimonit.com/abstract/index/idArt/909286
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http://dx.doi.org/10.12659/MSM.909286DOI Listing
January 2019
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Association of Bariatric Surgery Status with Reduced HER2+ Breast Cancers: a Retrospective Cohort Study.

Obes Surg 2019 Jan 19. Epub 2019 Jan 19.

Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115, United States.

Background: Bariatric surgery is associated with a reduced risk of developing certain malignancies, particularly in women. However, the impact of bariatric surgery on tumor characteristics, cancer treatment, and oncologic outcomes is unknown.

Method: In a retrospective cohort study, 42 subjects diagnosed with breast cancer after bariatric surgery (1989-2014) were matched to 84 subjects with breast cancer (1984-2012) who did not undergo bariatric surgery, based on age, body mass index (BMI), and menopausal status at the time of breast cancer diagnosis, as well as the date of cancer diagnosis. Read More

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http://link.springer.com/10.1007/s11695-018-03701-7
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http://dx.doi.org/10.1007/s11695-018-03701-7DOI Listing
January 2019
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DNA cleavage, DNA/HSA binding study, and antiproliferative activity of a phenolate-bridged binuclear copper(II) complex.

Biometals 2019 Jan 18. Epub 2019 Jan 18.

Flexible Display Materials & Technology, Co-Innovation Center of Hubei, Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, School of Chemistry and Environmental Engineering, Jianghan University, Wuhan, 430056, People's Republic of China.

A novel phenolate-bridged binuclear copper(II) complex, [Cu (L-3H)Cl] (1, where L = 2,6-bis[((2-hydroxybenzyl)(2-pyridylmethyl)amino)methyl]-4-methylphenol), have been synthesized and characterized. The antiproliferative activity of the complex has been tested in vitro against the human cervical cancer cell line HeLa, human non-small-cell lung cancer cell line A-549, the human breast cancer cell line MCF-7, and the human hepatic cell line LO2. The results show the complex has the low micromolar range (9. Read More

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http://dx.doi.org/10.1007/s10534-019-00172-wDOI Listing
January 2019

Re-testing of predictive biomarkers on surgical breast cancer specimens is clinically relevant.

Breast Cancer Res Treat 2019 Jan 18. Epub 2019 Jan 18.

Department of Oncology and Pathology, CCK, Karolinska Institutet, 17176, Stockholm, Sweden.

Purpose: The accuracy of predictive and prognostic biomarker assessment in breast cancer is paramount since these guide therapy decisions. The aim was to investigate the concordance of biomarkers and immunohistochemical (IHC)-based surrogate tumor subtypes between core needle biopsies (CNB) and consecutive paired breast cancer surgical resections.

Methods: This retrospective study comprised two cohorts of patients with primary breast cancer diagnosed between 2016 and 2017: one treated with primary surgery (n = 526) and one with neoadjuvant chemotherapy (NAC) (n = 216). Read More

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http://link.springer.com/10.1007/s10549-018-05119-2
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http://dx.doi.org/10.1007/s10549-018-05119-2DOI Listing
January 2019
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Comparative efficacy of palbociclib, ribociclib and abemaciclib for ER+ metastatic breast cancer: an adjusted indirect analysis of randomized controlled trials.

Breast Cancer Res Treat 2019 Jan 18. Epub 2019 Jan 18.

Medical Oncology Unit, ASST Bergamo Ovest, Piazzale Ospedale 1, 24047, Treviglio, BG, Italy.

Background: Several trials have demonstrated the benefit of anti-CDK4/6 inhibitors plus endocrine therapy in estrogen receptor-positive (ER+) advanced breast cancer (BC), in first or subsequent lines of therapy. However, due to the lack of direct/indirect comparisons, there are no data demonstrating the superiority of one drug over the other. We compared the effectiveness of palbociclib, ribociclib, and abemaciclib in advanced ER + BC via an indirect adjusted analysis. Read More

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http://dx.doi.org/10.1007/s10549-019-05133-yDOI Listing
January 2019

Aromatase inhibitor and tamoxifen use and the risk of venous thromboembolism in breast cancer survivors.

Breast Cancer Res Treat 2019 Jan 18. Epub 2019 Jan 18.

Department of Research & Evaluation, Kaiser Permanente Southern California, 100 South Los Robles, 2nd Floor, Pasadena, CA, 91101, USA.

Purpose: Venous thromboembolism (VTE) is the second most common cause of death in hospitalized patients with cancer, and cancer treatments may exacerbate VTE risk. Patients with hormone-receptor-positive breast cancer usually receive adjuvant endocrine therapy for 5 years or longer. The aim of this study is to examine VTE risk following long-term use of aromatase inhibitor (AI) compared with tamoxifen use among breast cancer survivors. Read More

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http://dx.doi.org/10.1007/s10549-018-05086-8DOI Listing
January 2019

Evaluation of Parathyroid Glands with Indocyanine Green Fluorescence Angiography After Thyroidectomy.

World J Surg 2019 Jan 18. Epub 2019 Jan 18.

Division of Breast, Endocrine, Metabolic and Gastrointestinal Surgery, Mayo Clinic, 200 1st St SW, Rochester, MN, 55902, USA.

Background: Indocyanine green fluorescence angiography (ICGA) is a new adjunct that has been used in surgical procedures to assess blood flow. This study evaluated the utility of ICGA compared to visual inspection to predict parathyroid function, guide autotransplantation and potentially decrease permanent hypoparathyroidism.

Methods: This was a retrospective study of patients who underwent total or near-total thyroidectomy (T-NT) between January 2015 and March 2018. Read More

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http://dx.doi.org/10.1007/s00268-019-04909-zDOI Listing
January 2019

Tuberous Breast Deformity Correction: 12-Years Experience.

Aesthetic Plast Surg 2019 Jan 18. Epub 2019 Jan 18.

Plastic and Reconstructive Microsurgery, Careggi University Hospital, Viale Giacomo Matteotti 42, 50132, Florence, Italy.

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http://dx.doi.org/10.1007/s00266-019-01307-7DOI Listing
January 2019

Molecular targeting of HER2-overexpressing biliary tract cancer cells with trastuzumab emtansine, an antibody-cytotoxic drug conjugate.

Cancer Chemother Pharmacol 2019 Jan 18. Epub 2019 Jan 18.

Product Research Department, Chugai Pharmaceutical Co., Ltd., 200 Kajiwara, Kamakura, Kanagawa, 247-8530, Japan.

Purpose: Trastuzumab emtansine (T-DM1) provides clinical benefit in breast cancers overexpressing human epidermal growth factor receptor 2 (HER2). However, its efficacy against biliary tract cancers (BTC) has not been evaluated. In this study, the effectiveness of T-DM1 in various BTC cell lines and xenograft models with different levels of HER2 expression was investigated. Read More

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http://dx.doi.org/10.1007/s00280-019-03768-8DOI Listing
January 2019

Author Correction: Landscape of somatic mutations in 560 breast cancer whole-genome sequences.

Nature 2019 Jan 18. Epub 2019 Jan 18.

Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.

In the Methods section of this Article, 'greater than' should have been 'less than' in the sentence 'Putative regions of clustered rearrangements were identified as having an average inter-rearrangement distance that was at least 10 times greater than the whole-genome average for the individual sample. '. The Article has not been corrected. Read More

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http://www.nature.com/articles/s41586-019-0883-2
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http://dx.doi.org/10.1038/s41586-019-0883-2DOI Listing
January 2019
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