467,966 results match your criteria Breast Abscess and Masses


Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 Dec 6;51(5):2065-2072. Epub 2018 Dec 6.

Department of General Surgery of East District, The Second Hospital of Hebei Medical University, Shijiazhuang,

Background/aims: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). Read More

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December 2018
8 Reads

Synergistic Activity of Paclitaxel, Sorafenib, and Radiation Therapy in advanced Renal Cell Carcinoma and Breast Cancer.

Transl Oncol 2018 Dec 3;12(2):381-388. Epub 2018 Dec 3.

Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120-752, South Korea; Department of Surgery, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea. Electronic address:

Advanced cancer has been shown to be associated with a higher percentage of epigenetic changes than with genetic mutations. Preclinical models have shown that the combination of paclitaxel, sorafenib, and radiation therapy (RT) plays a crucial role in renal cell carcinoma (RCC) and breast cancer. This study aimed to investigate the involvement of mitochondrial cytochrome c-dependent apoptosis in the mechanism of action of a combination of paclitaxel, sorafenib, and RT in RCC and breast cancer. Read More

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December 2018
1 Read

Associations Between PET Parameters and Expression of Ki-67 in Breast Cancer.

Transl Oncol 2018 Dec 3;12(2):375-380. Epub 2018 Dec 3.

Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Magdeburger Str., 06097 Halle, Germany. Electronic address:

Objectives: Numerous studies investigated relationships between positron emission tomography and proliferation index Ki-67 in breast cancer (BC) with inconsistent results. The aim of the present analysis was to provide evident data about associations between standardized uptake value (SUV) and expression of Ki-67 in BC.

Methods: MEDLINE library, SCOPUS and EMBASE data bases were screened for relationships between SUV and Ki-67 in BC up to April 2018. Read More

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December 2018
2 Reads

Long non-coding RNA SNHG6 enhances cell proliferation, migration and invasion by regulating miR-26a-5p/MAPK6 in breast cancer.

Biomed Pharmacother 2018 Dec 3;110:294-301. Epub 2018 Dec 3.

Department of breast surgery, The first affiliated hospital of Zhengzhou University, Zhengzhou City, Henan Province, China.

The long non-coding RNA (lncRNA) has recently been shown to be important regulators involved in the progression of various human cancers. Small nucleolar RNA host gene 6 (SNHG6) is a recently identified cancer-related lncRNA. However, the clinical significance and biological function of SNHG6 in breast cancer (BC) are still unclear. Read More

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December 2018
2 Reads

A PALB2 truncating mutation: Implication in cancer prevention and therapy of Hereditary Breast and Ovarian Cancer.

Breast 2018 Nov 29;43:91-96. Epub 2018 Nov 29.

Cancer Genetics Group, Institute of Genetics and Molecular Biology (UVa-CSIC), Sanz y Forés 3, 47003 Valladolid, Spain. Electronic address:

Explaining genetic predisposition in Hereditary Breast and Ovarian Cancer (HBOC) families without BRCA mutations is crucial. Germline PALB2 inactivating mutations were associated with an increased risk of HBOC due to its role in DNA repair through cooperation with BRCA proteins. The prevalence and penetrance of PALB2 mutations in Spanish HBOC patients remains unexplained. Read More

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November 2018
2 Reads

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2018 Nov 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

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November 2018
2 Reads

Preparation and optimization of poly (lactic acid) nanoparticles loaded with fisetin to improve anti-cancer therapy.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

Fisetin is a natural flavonoid with promising antitumor activity, whereas its clinical application is limited by its hydrophobic property. In this study, we aimed to load fisetin into poly(lactic acid) (PLA) nanoparticles to increase fisetin's solubility and therapeutic efficacy. Based on spontaneous emulsification solvent diffusion (SESD) method, the formulation of PLA nanoparticles was optimized by two successive experimental designs. Read More

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December 2018
1 Read

Anticancer activity modulation of an innovative solid formulation of extra virgin olive oil by cultured zeolite scaffolds.

Food Chem Toxicol 2018 Dec 3. Epub 2018 Dec 3.

Research Institute on Membrane Technology, Unit of Zeolite Membranes, ITM-CNR, University of Calabria, Cubo 17/c, 87036, Rende, Italy.

This paper deals with the design and manufacture of pure and hybrid synthetic (Mixed Matrix Membranes, MMMs) zeolite scaffolds (containing various amount of zeolite crystals dispersed in a polymeric matrix) to obtain new biomaterials. These scaffolds can potentially be used in the field of translational medicine to obtain innovative results to address tumorigenesis mechanisms with the promotion of an effort to deal with technical methods and information. Since olive oil has beneficial effects in healthy human cells and slows down and/or inhibits cell growth, the aim of this work was to monitor the protective and beneficial antitumor effects of olive oil in a new solid formulation (Spread Bio-Oil) on cancer cell cultured on zeolite scaffolds. Read More

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December 2018

Cabazitaxel and Thymoquinone co-loaded Lipospheres as a Synergistic Combination for Breast Cancer.

Chem Phys Lipids 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, 500037, India. Electronic address:

Cabazitaxel as microtubule inhibitor and thymoquinone as HDAC inhibitor affects the important genes like p53, STAT3, Bax, BCL-2, p21 and down regulation of NF-κB are reported for potential activity against breast tumors. However, poor aqueous solubility and permeability hinders the delivery of these drugs to target site. To address the delivery challenges cabazitaxel and thymoquinone co-loaded lipospheres were developed. Read More

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December 2018

Analysis of the Expression and Regulation of PD-1 Protein on the Surface of Myeloid-Derived Suppressor Cells (MDSCs).

Biomol Ther (Seoul) 2018 Dec 6. Epub 2018 Dec 6.

Division of Biological Sciences, Research Institute of Women's Health and Cellular Heterogeneity Research Center, Sookmyung Women's University, Seoul 04310, Republic of Korea.

Myeloid-derived suppressor cells (MDSCs) that are able to suppress T cell function are a heterogeneous cell population frequently observed in cancer, infection, and autoimmune disease. Immune checkpoint molecules, such as programmed death 1 (PD-1) expressed on T cells and its ligand (PD-L1) expressed on tumor cells or antigen-presenting cells, have received extensive attention in the past decade due to the dramatic effects of their inhibitors in patients with various types of cancer. In the present study, we investigated the expression of PD-1 on MDSCs in bone marrow, spleen, and tumor tissue derived from breast tumor-bearing mice. Read More

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December 2018
1 Read

Pharmacological treatment of obesity

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):395-409. Epub 2018 Nov 30.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica en Endocrinología Experimental. Ciudad de México, México

More than 70% of the population in Mexico is overweight or obese, affecting mainly people in productive age. Obesity is associated with the development of diseases that increase cardiovascular risk (diabetes mellitus, hypertension or atherogenic dyslipidemia), diseases that limit the quality of life of the patient (osteoarthrosis or sleep apnea) and even with the increase in the incidence of certain types of cancer (breast or colon). It is evident that the decrease of at least 5% of body weight induces improvement in all these factors; however, in some patients it is difficult to achieve this goal only with lifestyle modifications. Read More

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November 2018
1 Read

[Syndrome of vertebral destruction: understanding to practice].

Acta Ortop Mex 2018 May-Jun;32(3):182-187

Hospital Centro Médico de Occidente. Instituto Mexicano del Seguro Social (IMSS). Guadalajara, Jalisco. México.

The term «vertebral destruction syndrome» comprises pathologies causing structural changes in the spine, mainly in the vertebral body, producing mechanical deformity and neurological involvement. The pathologies found in this definition may be infectious, metabolic or tumoral. Vertebral osteomyelitis is a disease that occurs mainly in adults > 50 years; we speak of spondylodiscitis when the condition affects the disc and vertebral body. Read More

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December 2018
1 Read

Oral and intrauterine progestogens for atypical endometrial hyperplasia.

Cochrane Database Syst Rev 2018 Dec 4;12:CD009458. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, Section Three, Ren Min Nan Lu Avenue, Chengdu, Sichuan, China, 610041.

Background: Endometrial carcinoma is the most common gynaecologic malignancy in the world and develops through preliminary stages of endometrial hyperplasia. Atypical endometrial hyperplasia suggests a significant pre-malignant state with frank progression to endometrial carcinoma, and tends to occur at a young age. Oral progestins have been used as conservative treatment in young women with atypical endometrial hyperplasia, but they are associated with poor tolerability and side effects that may limit their overall efficacy. Read More

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December 2018
3 Reads

Evaluation of the prognostic value of all four HER family receptors in patients with metastatic breast cancer treated with trastuzumab: A Hellenic Cooperative Oncology Group (HeCOG) study.

PLoS One 2018 6;13(12):e0207707. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

In the current study, we performed a complete analysis, with four different methods, of all four HER family receptors, in a series of patients with metastatic breast cancer treated with trastuzumab-based regimens and evaluated their prognostic value. Formalin-fixed paraffin-embedded tumor tissue samples were collected from 227 patients, considered to be HER2-positive when assessed at the local laboratories. We evaluated gene amplification, copy number variations (CNVs), mRNA and protein expression of all four HER family members. Read More

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December 2018
1 Read

Circlular RNA BARD1 (Hsa_circ_0001098) overexpression in breast cancer cells with TCDD treatment could promote cell apoptosis via miR-3942/BARD1 axis.

Cell Cycle 2018 Dec 6. Epub 2018 Dec 6.

b Department of Thoracic Surgery , Shengjing Hospital of China Medical University , Shenyang 110004 , Liaoning , China.

Breast cancer threatened the health of millions of people around the world. Here we explored the influence of TCDD on the expression of circRNA_BARD1 (circ_0001098) in breast cancer and studied the potential molecular mechanism of circRNA_BARD1. The data from GSE76608 was applied to analyze differentially expressed circRNAs and mRNAs. Read More

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December 2018
1 Read

MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions.

FASEB J 2018 Dec 6:fj201801127R. Epub 2018 Dec 6.

Institute of Molecular Medicine and Cell Research, Medical Faculty, University of Freiburg, Freiburg, Germany.

Tumor-initiating cells (TICs) existing in breast cancer are thought to be involved in initiation, progression, and relapse of tumors. In these processes, the epithelial-to-mesenchymal transition (EMT) and proteases are crucial factors that also dependent on the tumor milieu, including hypoxic nutrient-deprived, as well as normoxic nutrient-rich, environments. Therefore, we investigated EMT and proteases in TICs and their response to different environments by means of a newly generated immortalized TIC (iTIC) line. Read More

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December 2018
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Occurrence and human exposure assessment of short- and medium-chain chlorinated paraffins in dusts from plastic sports courts and synthetic turf in Beijing, China.

Environ Sci Technol 2018 Dec 6. Epub 2018 Dec 6.

This study presents the first investigation of concentrations and congener group patterns of short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) in 159 dust samples from plastic sports courts and synthetic turf in Beijing, China. The geometric mean concentration of SCCPs and MCCPs in dusts from plastic tracks (5429 and 15157 μg g-1) and basketball courts (5139 and 11878 μg g-1) were significantly higher than those from plastic tennis courts, badminton courts, and synthetic turf, meanwhile they were 1-3 orders of magnitude higher than those in dusts from other indoor environments. The friction between sneaker soles and plastic track materials may lead to the wear and decomposition of rubber, which may be an important source of chlorinated paraffins (CPs) in the dust from plastic tracks. Read More

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December 2018

Breast cancer in males, case presentation and literature review

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):424-428. Epub 2018 Nov 30.

Instituto de Seguridad Social del Estado de México y Municipios, Centro Médico ISSEMyM Ecatepec, Servicio de Cirugía General. Ecatepec, Estado de México, México

Background: Male breast cancer is a rare entity, with an approximate rate of 1.1 / 100 000 in the US, with an average age of 67 years. In all cases a genetic study must be performed, in order to find mutations in known genes, and after the resolution of the disease, based on the results, a contralateral prophylactic mastectomy should be considered. Read More

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November 2018
1 Read

Breast implant-associated anaplastic large cell lymphoma: Clinical and imaging findings at a large US cancer center.

Breast J 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York City, New York.

Purpose: Evaluate the clinical presentation and imaging findings of breast implant-associated anaplastic large cell lymphoma (BIA ALCL) at a large US cancer center.

Materials And Methods: HIPAA-compliant IRB approved retrospective study, for which informed consent was waived. The Hospital Information System was screened for women who underwent implant reconstruction and were diagnosed with BIA ALCL between 2010 and 2016. Read More

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December 2018

Appearance of di- and Tripeptides in Human Plasma after a Protein Meal does not Correlate with PEPT1 Substrate Selectivity.

Mol Nutr Food Res 2018 Dec 6:e1801094. Epub 2018 Dec 6.

F. Rohm, Dr. H. Daniel, Dr. B. Spanier, Nutritional Physiology, Technical University of Munich, Freising, Germany.

Scope: PEPT1 function is well understood, yet little is known about its contribution towards the absorption of dietary amino acids in the form of di- and tripeptides. In the present human study, we investigated changes in plasma concentrations of a representative oligopeptide panel after meat intake.

Methods And Results: Based on an LC-MS/MS method for quantitative analysis of a panel of selected di- and tripeptides in biological samples, we describe the kinetics of plasma changes of peptides derived from a widely accessible dietary protein source. Read More

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December 2018

The role of post-mastectomy radiotherapy in elderly patients with 1-3 positive lymph nodes breast cancer: An International Retrospective Double-Center Study.

Breast J 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Institut Curie, Paris, France.

This study evaluated the role of post-mastectomy radiotherapy (PMRT) in 111 patients with 1-3 positive nodes, aged 65 years or above between 2007 and 2013. In total, 64 received PMRT. The PMRT group had more aggressive tumor. Read More

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December 2018

Early surveillance is associated with less incidence and severity of breast cancer-related lymphedema compared with a traditional referral model of care.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Australian Lymphoedema Education, Research and Treatment (ALERT) Program, Department of Clinical Medicine, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales, Australia.

Background: Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral model of care.

Methods: In a retrospective analysis of data from 753 women who underwent BIS measures between January 1, 2007 and December 31, 2016, 188 women were assigned to the "early surveillance" group if they began lymphedema monitoring presurgery (n = 121) or within 90 days postsurgery (n = 67), and 285 women were assigned to the "traditional referral" group if they began monitoring after 90 days postsurgery. Read More

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December 2018
1 Read

Insomnia in breast cancer: a prospective observational study.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

CRUK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow.

Study Objectives: Insomnia in cancer patients is prevalent, persistent and confers risk for physical and psychological disorder. We must better understand how insomnia develops in cancer patients and explore the main contributors to its chronicity so that insomnia management protocols can be integrated more effectively within cancer care. This study monitors the etiology of insomnia in breast cancer patients and identifies risk factors for its persistence. Read More

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December 2018
2 Reads

Pediatric Office Delivery of Smoking Cessation Assistance for Breast-Feeding Mothers.

Nicotine Tob Res 2018 Dec 6. Epub 2018 Dec 6.

Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA.

Introduction: National and international organizations have done an excellent job of advocating and promoting breast feeding for all mothers. This study assessed to what extent an intervention increased delivery of cessation assistance to breast-feeding mothers who smoke.

Methods: Data were collected between April and October 2015 in five US states as part of a cluster randomized controlled trial in 10 pediatric practices. Read More

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December 2018
1 Read

Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

Institute of Cell Biology and Genes and Development Group, CDBS Hugh Robson Building, University of Edinburgh, Edinburgh, UK.

Study Question: Does ovarian follicle activation by phosphatase homologue of chromosome-10 (PTEN) inhibition affect DNA damage and repair in bovine oocytes and granulosa cells?

Summary Answer: PTEN inhibition promotes bovine non-growing follicle activation but results in increased DNA damage and impaired DNA repair capacity in ovarian follicles in vitro.

What Is Known Already: Inhibition of PTEN is known to activate primordial follicles but may compromise further developmental potential. In breast cancer cells, PTEN inhibition represses nuclear translocation of breast cancer susceptibility 1 (BRCA1) and Rad51; this impairs DNA repair resulting in an accumulation of damaged DNA, which contributes to cell senescence. Read More

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December 2018

Normal Weight Adiposity and Postmenopausal Breast Cancer Risk.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Division of Medical Oncology and Hematology, Department of Medicine, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

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December 2018

MODELLING γ-H2AX FOCI INDUCTION TO MIMIC LIMITATIONS IN THE SCORING TECHNIQUE.

Radiat Prot Dosimetry 2018 Dec 6. Epub 2018 Dec 6.

Physics Department, University of Pavia, Pavia, Italy.

An approach based on track-structure calculations has been developed to take account of artefacts occurring during γ-H2AX foci detection in 2D images of samples analyzed through immunocytochemistry. The need of this works stems from the observed saturation in foci yields measured after X-ray doses higher than few grays, hindering an unambiguous quantification of DNA damage and of radiation effectiveness. The proposed modelling approach allows to simulate the observer's point of view for foci scoring, mimicking the selection of a slice Δz of the cell nucleus due to the microscope depth of field, and applying a clustering algorithm to group together damages within a resolution parameter r. Read More

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December 2018
1 Read

LONG-TERM HEALTH RISK AFTER BREAST-CANCER RADIOTHERAPY: OVERVIEW OF PASSOS METHODOLOGY AND SOFTWARE.

Radiat Prot Dosimetry 2018 Dec 6. Epub 2018 Dec 6.

Klinik für Strahlentherapie, Universität Leipzig, Stephanstr. 9a, Leipzig, Germany.

Breast-cancer radiotherapy reduces the recurrence rates and improves patient survival. However, it also increases the incidence of second cancers and of heart disease. These radiation-induced long-term health risks become increasingly important with improved cure rates and prolonged patient survival. Read More

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December 2018

Association of Body Fat and Risk of Breast Cancer in Postmenopausal Women With Normal Body Mass Index: A Secondary Analysis of a Randomized Clinical Trial and Observational Study.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Weill Cornell Medical College, New York, New York.

Importance: Obesity is associated with an increased risk of breast cancer, including the estrogen receptor (ER)-positive subtype in postmenopausal women. Whether excess adiposity is associated with increased risk in women with a normal body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) is unknown.

Objective: To investigate the association between body fat and breast cancer risk in women with normal BMI. Read More

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December 2018
2 Reads

Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

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December 2018

Trastuzumab Therapy for 9 Weeks vs 1 Year for Human Epidermal Growth Factor 2-Positive Breast Cancer-Reply.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Oncology, Helsinki University Hospital, Helsinki University, Helsinki, Finland.

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December 2018

Assessment of ERBB2/HER2 Status in HER2-Equivocal Breast Cancers by FISH and 2013/2014 ASCO-CAP Guidelines.

JAMA Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Medicine, Geffen School of Medicine at University of California Los Angeles, Los Angeles.

Importance: The 2013/2014 American Society of Clinical Oncology and College of American Pathologists (ASCO-CAP) guidelines for HER2 testing by fluorescence in situ hybridization (FISH) designated an "equivocal" category (average HER2 copies per tumor cell ≥4-6 with HER2/CEP17 ratio <2.0) to be resolved as negative or positive by assessments with alternative control probes. Approximately 4% to 12% of all invasive breast cancers are characterized as HER2-equivocal based on FISH. Read More

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December 2018

T-cell Activating Tribodies as a Novel Approach for Efficient Killing of ErbB2-positive Cancer Cells.

J Immunother 2019 Jan;42(1):1-10

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II.

The Tyrosine Kinase Receptor ErbB2 (HER2) when overexpressed in breast cancer (BC) is associated with poor prognosis. The monoclonal antibody Trastuzumab has become a standard treatment of ErbB2+BC. The antibody treatment has limited efficacy, often meets resistance and induces cardiotoxicity. Read More

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January 2019

Activation of GPR120 promotes the metastasis of breast cancer through the PI3K/Akt/NF-κB signaling pathway.

Anticancer Drugs 2018 Dec 4. Epub 2018 Dec 4.

Department of Laboratory Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.

G-protein-coupled receptor 120 (GPR120) plays an important role in regulating lipid and glucose metabolism as a long-chain unsaturated fatty acid receptor. However, it has been widely accepted that omega-3 polyunsaturated fatty acids are not dependent on the activation of GPR120 to exert anti-tumor activity. Therefore, the role of GPR120 in tumor development has not yet been elucidated. Read More

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December 2018
3 Reads

Translational highlights in breast cancer research and treatment: recent developments with clinical impact.

Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of Hematology, Oncology and Tumour Immunology, Charité University Hospital Berlin, Campus Benjamin Franklin, Berlin, Germany.

Purpose Of Review: Over the last decades the time which is needed to translate a preclinical finding or idea in the clinic has reduced continuously. Especially but not only for breast cancer the number of tested drugs and targeted pathways have increased immensely. In addition, the introduction of immune-oncological treatments has further advanced the possibilities for future treatments. Read More

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December 2018
1 Read

Cyclin-dependent kinase 4/6 inhibitors: what have we learnt across studies, therapy situations and substances.

Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology and Obstetrics, Regio Klinikum Pinneberg, Pinneberg, Germany.

Purpose Of Review: Cyclin-dependent kinases (CDK) are key regulatory enzymes that control cell cycle and cell division. In the recent years, new therapeutic options selectively targeting CDK 4 and 6 have shown promising clinical activity in several solid tumors. Since 2015, three CDK 4/6 inhibitors have been approved for treatment of hormone receptor-positive HER2-negative metastatic breast cancer: palbociclib, ribociclib and abemaciclib. Read More

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December 2018

Posttraumatic Stress Disorder and Cancer Risk: A Nested Case-Control Study.

J Trauma Stress 2018 Dec 6. Epub 2018 Dec 6.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Data regarding cancer risk for individuals who were exposed to traumatic and stressful life events are conflicting. We sought to evaluate the association between posttraumatic stress disorder (PTSD) and the risk of the four most common solid tumors: lung, breast, prostate, and colorectal cancers. We conducted four nested case-control studies using a large UK population-based database. Read More

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December 2018
1 Read

Trends in the incidence and mortality of cancer in Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1259-1262

Biochemistry Department, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To analyze the overall trends in cancer incidence and mortality in Saudi Arabia between 1990 and 2016.   Methods: Data were retrieved through a Global Burden of Disease (GBD, 2016) database (Viz Hub) that is developed by the Institute for Health Metrics and Evaluation at the University of Washington. Results: The incidence of cancer increased around 26-fold for thyroid cancer; approximately 10-fold in breast, colon, bladder and uterine cancers; 8-fold for prostate cancer; 5-fold for renal cancer; 4-fold for pancreatic and ovarian cancer; 3. Read More

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December 2018
3 Reads

miR-342-5p as a potential regulator of HER2 breast cancer cell growth.

Microrna 2018 Dec 6. Epub 2018 Dec 6.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo. Norway.

HER2 positive breast cancers (BC) have aggressive behavior and poor prognosis. Previously, we have identified miR-342-5p as an upstream regulator of HER2 signaling, as well as inhibitor of HER2 positive BC cell line growth. Here, we aimed to further investigate the molecular mechanisms behind miR-342-5p-induced HER2 pathway deregulation. Read More

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December 2018
1 Read

Doxorubicin effects on leukemia and breast cancer cells in culture on the TK1 protein levels using AroCell TK 210 ELISA: a tool for drug development.

Nucleosides Nucleotides Nucleic Acids 2018 Dec 6:1-8. Epub 2018 Dec 6.

a Department of Anatomy, Physiology and Biochemistry , Swedish University of Agricultural Sciences , VHC , Uppsala , Sweden.

In this study changes in thymidine kinase 1 (TK1) levels after 24 hours of Doxorubicin (Dox) exposure of CEM and MDA MB-231 cells were determined using the commercially available AroCell TK 210 ELISA test. In cell extracts, TK1 levels increased twofold with 1 µM Dox in both cell lines, while the TK1 levels in the culture media increased with 5 and 10 µM of Dox only in case of CEM cells. In conclusion, this study reveals that the TK 210 ELISA can measure changes in intra- and extracellular TK1 levels apparently related to the mechanism of cytotoxicity of anti-cancer agents. Read More

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December 2018

Targeted Feature Extraction in MALDI Mass Spectrometry Imaging to Discriminate Proteomic Profiles of Breast and Ovarian Cancer.

Proteomics Clin Appl 2018 Dec 6:e1700168. Epub 2018 Dec 6.

University of Bremen, Bremen, Germany.

Purpose: To develop a mass spectrometry imaging (MSI) based workflow for extracting m/z values related to putative protein biomarkers and using these for reliable tumor classification.

Experimental Design: Given a list of putative breast and ovarian cancer biomarker proteins, we extracted a set of related m/z values from heterogeneous MSI datasets derived from formalin-fixed paraffin-embedded tissue material. Based on these features, a linear discriminant analysis classification model was trained to discriminate the two tumor types. Read More

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December 2018

Response shift effects of quality of life assessments in breast cancer survivors.

Eur J Cancer Care (Engl) 2018 Dec 6:e12979. Epub 2018 Dec 6.

Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.

Measurements of quality of life (QoL) can be distorted by respondents adapting to new situations between measurement points and consequently having a changed frame of reference. To investigate this bias in breast cancer survivors, we compare their QoL with that of the general population and use two complementary methods for detecting this bias. Breast cancer survivors (n = 308, response rate: 91%) were tested with the QoL questionnaire European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30. Read More

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December 2018
1 Read

ERBB2 mutation frequency in lobular breast cancer with pleomorphic histology or high-risk characteristics by molecular expression profiling.

Genes Chromosomes Cancer 2018 Dec 5. Epub 2018 Dec 5.

Institute of Pathology, Hannover Medical School, Hannover, Germany.

HER2-positive breast cancer is defined by amplification or overexpression of the HER2/ERBB2 oncogene and accounts for about 15% of breast cancer (BC) cases. Somatic mutation of ERBB2 is an alternative mechanism, by which activation of HER2 signaling can occur. ERBB2 mutation has been associated with invasive lobular breast cancer (ILBC). Read More

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December 2018
1 Read

hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signalling pathway.

Mol Carcinog 2018 Dec 5. Epub 2018 Dec 5.

Oncology Institute, Affiliated Hospital of Jiangnan University, Wuxi 214062, China.

Emerging research has indicated that circular RNAs (circRNAs), a novel class of non-coding RNAs, play a vital role in human tumourigenesis and progression. Our previous results suggested that hsa_circ_0006528 (circ_0006528), a circRNA with an unknown function, mediates adriamycin resistance in human breast cancer cells. However, the role of circ_0006528 in breast cancer progression remains unknown. Read More

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December 2018

Knockdown of sal-like 4 expression by small interfering RNA induces apoptosis in breast cancer cells.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Biotechnology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.

Breast cancer is the most prevalent cancers worldwide and causes a significant amount of deaths annually. Spalt-like transcription factor 4 is known as a transcription factor, which has an important role in the proliferation of cancerous cells. Small interfering RNA (siRNA) is a short-chain molecule of 20 to 25 nucleotides that protrude on two sides of the 3', two nucleotides. Read More

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December 2018

Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response.

Prostate 2018 Dec 5. Epub 2018 Dec 5.

Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands.

Background: In vitro models of prostate cancer (PCa) are not always reliable to evaluate anticancer treatment efficacy. This limitation may be overcome by using viable tumor slice material. Here we report on the establishment of an optimized ex vivo method to culture tissue slices from patient-derived xenografts (PDX) of prostate cancer (PCa), to assess responses to PCa treatments. Read More

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December 2018
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MicroRNA-590-3P suppresses cell survival and triggers breast cancer cell apoptosis via targeting sirtuin-1 and deacetylation of p53.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Downregulation of microRNA-590-3p (miR-590-3p) is a frequently occurring, nonphysiological event which is observed in several human cancers, especially breast cancer. However, the significance of miR-590-3p still remain unclear in the progression of this disease. This study explored the role of miR-590-3p in apoptosis of breast cancer cells. Read More

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December 2018

A four-gene signature predicts the efficacy of paclitaxel-based neoadjuvant therapy in human epidermal growth factor receptor 2-negative breast cancer.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Pathology, Shengjing Hospital of China Medical University, Shenyang, China.

Neoadjuvant chemotherapy (NAC) is the major preoperative treatment of breast cancer (BC) with negative human epidermal growth factor receptor 2 (HER2), and the efficacy of NAC and the optimization of regimen are under intensive research. The current study aimed to define the predictive biomarkers for paclitaxel (PTX) response in NAC of HER2-negative BC. Data from GSE25065, GSE26065, GSE41998, as well as drug sensitivity data of breast and ovarian cancer cell line from NCI60, were used. Read More

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December 2018
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PREDECT Protocols for Complex 2D/3D Cultures.

Methods Mol Biol 2019 ;1888:1-20

Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.

PREDECT, a European IMI consortium, has assumed the task to generate robust 2D and 3D culture platforms. Protocols established for 2D and 3D monoculture and stromal coculture models of increasing complexity (spheroid, stirred-tank bioreactor, Matrigel- and collagen-embedded cultures) have been established between six laboratories within academia, biotech, and pharma. These models were tested using three tumor cell lines (MCF7, LNCaP, and NCI-H1437), covering three pathologies (breast, prostate, and lung), but should be readily transferable to other model systems. Read More

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January 2019