47,768 results match your criteria Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology][Journal]


Novel mutations in the bone morphogenetic protein 6 gene in patients with iron overload and non-homozygous genotype for the HFE p.Cys282Tyr mutation.

Blood Cells Mol Dis 2020 May 18;84:102444. Epub 2020 May 18.

Department of Pharmacology - Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM-Unifesp), São Paulo, Brazil. Electronic address:

Background: Five main genes are associated with hemochromatosis; however, current studies show that, in addition to these genes, others may be associated with primary iron overload (IO). One of these is the bone morphogenetic protein 6 (BMP6), which encodes a protein that modulates hepcidin synthesis and, consequently, iron homeostasis.

Aim: To identify BMP6 gene pathogenic variants in patients with IO and non-homozygous genotype for the HFE p. Read More

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http://dx.doi.org/10.1016/j.bcmd.2020.102444DOI Listing

Merulinic acid C overcomes gentamicin resistance in Enterococcus faecium.

Bioorg Chem 2020 May 12;100:103921. Epub 2020 May 12.

Brazilian Biosciences National Laboratory (LNBio), CNPEM, 13083-970 Campinas, SP, Brazil; Univ. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble, France. Electronic address:

Enterococci are gram-positive, widespread nosocomial pathogens that in recent years have developed resistance to various commonly employed antibiotics. Since finding new infection-control agents based on secondary metabolites from organisms has proved successful for decades, natural products are potentially useful sources of compounds with activity against enterococci. Herein are reported the results of a natural product library screening based on a whole-cell assay against a gram-positive model organism, which led to the isolation of a series of anacardic acids identified by analysis of their spectroscopic data and by chemical derivatizations. Read More

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http://dx.doi.org/10.1016/j.bioorg.2020.103921DOI Listing

Good times, bad times: Resource pulses influence mammal diversity in meridional Brazilian highlands.

Sci Total Environ 2020 May 15;734:139473. Epub 2020 May 15.

Universidade de São Paulo (USP), Escola Superior de Agricultura "Luiz de Queiroz" (ESALQ), Departamento de Ciências Florestais, Laboratório de Ecologia, Manejo e Conservação de Fauna Silvestre (LEMaC), Piracicaba, SP 13418-900, Brazil.

Understanding spatiotemporal patterns of species distributions and their determinants is paramount in ecology. Here, we explore the relationship between the diversity of surviving mammals and two of the main alimentary resources (araucaria seeds and feijoa fruits) across the Araucaria Forest (FOM) in South America. First, we investigated the influence of landscape and environment on the species distribution and pulse of forest productivity. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139473DOI Listing

Humic extracts from hydrochar and Amazonian Anthrosol: Molecular features and metal binding properties using EEM-PARAFAC and 2D FTIR correlation analyses.

Chemosphere 2020 May 22;256:127110. Epub 2020 May 22.

Department of Chemistry and Environmental Sciences, São Paulo State University (UNESP), Institute of Biosciences, Humanities and Exact Sciences (IBILCE), São José do Rio Preto, São Paulo, Brazil. Electronic address:

Organic matter plays many roles in the soil ecosystem. One property of the substance concerns the metal complexation and interaction with organic contaminants. In this sense, the humic substances (HS), a heterogeneous mixture of compounds, naturally derived from degradation of biomass, have been widely studied in environmental sciences. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2020.127110DOI Listing

DOES DENTAL TRAUMA AND ITS CONSEQUENCES INFLUENCE THE PROFESSIONAL HIRING PROCESS? DEVELOPMENT, VALIDATION AND APPLICATION OF AN ASSESSMENT TOOL.

J Dent 2020 May 25:103385. Epub 2020 May 25.

School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Southwest Bahia State University UESB, Jequie, Bahia, Brazil. Electronic address:

Objectives: To develop and validate a questionnaire concerning the aspects evaluated during the hiring process by human resources professionals (HRPs); to apply the validated questionnaire; and to evaluate the perceptions and judgment of HRPs regarding different traumatic dental injuries (TDIs) and their consequences (TDI-Cs).

Materials And Methods: The acceptability, discriminative properties, internal consistency and test-retest reliability of the developed questionnaire were evaluated, using the same methodology as the main study and adopting a pilot sample. For both the validation process and the application phase, images of one male and one female were manipulated, or not (control), to create different types of TDI (enamel fracture, enamel and dentin fracture, avulsion) and TDI-Cs (crown discoloration, tooth loss due to avulsion). Read More

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http://dx.doi.org/10.1016/j.jdent.2020.103385DOI Listing

In silico, in vitro and in vivo evaluation of natural Bignoniaceous naphthoquinones in comparison with atovaquone targeting the selection of potential antimalarial candidates.

Toxicol Appl Pharmacol 2020 May 25:115074. Epub 2020 May 25.

Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG 31.270-901, Brazil. Electronic address:

The natural naphthoquinones lapachol, α- and β-lapachone are found in Bignoniaceous Brazilian plant species of the Tabebuia genus (synonym Handroanthus) and are recognized for diverse bioactivities, including as antimalarial. The aim of the present work was to perform in silico, in vitro and in vivo studies to evaluating the antimalarial potential of these three naphthoquinones in comparison with atovaquone, a synthetic antimalarial. The ADMET properties of these compounds were predicted in silico by the preADMET program. Read More

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http://dx.doi.org/10.1016/j.taap.2020.115074DOI Listing

Seroprevalence and factors associated with HIV-1, HTLV and Hepatitis B/C infections in parturient women of Salvador - Bahia, Brazil.

Braz J Infect Dis 2020 May 25. Epub 2020 May 25.

Universidade Federal da Bahia, Faculdade de Medicina, Salvador, BA, Brazil; Universidade Federal de Bahia, Complexo Hospitalar Universitário Professor Edgard Santos, Salvador, BA, Brazil.

Background: The heterogeneity in detection rates of HIV, HTLV and Hepatitis B/C infections among pregnant women and the continuous exposure to risk factors limits the adoption of preventive and control actions.

Objective: To evaluate the HIV, HTLV, Hepatitis B and C seroprevalence rates, and associated risk factors in parturient women in Salvador, Brazil.

Methods: This was a cross-sectional study in 2099 parturient women attended in two public maternity hospitals in Salvador, Brazil. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.05.001DOI Listing

Diet composition of the electric eel Electrophorus voltai (Pisces: Gymnotidae) in the Brazilian Amazon region.

J Fish Biol 2020 May 28. Epub 2020 May 28.

Postgraduate Program on Tropical Biodiversity (PPGBio), Federal University of Amapá, Macapá, AP, Brazil.

The diet composition of the electric eel Electrophorus voltai was studied in specimens collected from the River Jari, state of Amapá, eastern Amazon region, Brazil. Analysis on the contents of their stomachs revealed that fish were the most frequent prey item, especially Megalechis thoracata, while the least frequent intakes were arthropods and plant material. This is the first stomach content analysis on E. Read More

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http://dx.doi.org/10.1111/jfb.14413DOI Listing

Arboviral diseases and COVID-19 in Brazil: Concerns regarding climatic, sanitation and endemic scenario.

J Med Virol 2020 May 28. Epub 2020 May 28.

Laboratory of Emerging Infectious Diseases, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, PR, 80215-901, Brazil.

Brazil is witnessing a massive increase of COVID-19 cases and may face some difficulties, not only regarding to other respiratory pathogens, but also to other relevant issues parallelly occurring, for instance, the beggining of autumn and winter seasons, which provides a longer period with high transmissibility of respiratory viroses. Additionally, Brazil is localized in a geographical tropical area with relevant arboviral diseases, where Dengue fever presented highest incidence during March-June, mainly at Southeast and Midwest regions, where probably it will occur overlapping curves of arboviruses and COVID-19, which will overload our public health system. The main affected áreas by COVID-19 in Brazil were the same that presented 66% of the Dengue fever cases in Brazil. Read More

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http://dx.doi.org/10.1002/jmv.26079DOI Listing

Ecosystem Services Provided by Insects in Brazil: What Do We Really Know?

Neotrop Entomol 2020 May 28. Epub 2020 May 28.

Depto de Ecologia, Univ de Brasília - UnB, Brasília, DF, Brasil.

Insects are the most abundant and diverse organisms on Earth and provide essential ecosystem services. However, Brazilian society rarely consider the importance of insects in their diverse country. Therefore, in this review, we provide an overview of ecosystem services provided by insects in Brazil. Read More

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http://dx.doi.org/10.1007/s13744-020-00781-yDOI Listing

Characterization and strong risk association of to polymorphism and and their influence on mRNA expression in gastric cancer.

World J Gastrointest Oncol 2020 May;12(5):535-548

Department of Molecular Biology, São José do Rio Preto School of Medicine, São José do Rio Preto, São Paulo 15090-000, Brazil.

Background: Toll-like receptor-2 () is responsible for recognizing () and activating the immune response. Polymorphisms in may modulate gastric carcinogenesis.

Aim: To evaluate whether the (rs3804099) and - (rs111200466) polymorphisms contribute to gastric carcinogenesis in the Brazilian population, and to determine the influence of both polymorphisms and infection on mRNA expression. Read More

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http://dx.doi.org/10.4251/wjgo.v12.i5.535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235183PMC

Rational engineering of the RUT-C30 strain into an industrially relevant platform for cellulase production.

Biotechnol Biofuels 2020 22;13:93. Epub 2020 May 22.

Brazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, São Paulo 13083-100 Brazil.

Background: The path for the development of hypersecreting strains of capable of producing industrially relevant enzyme titers remains elusive despite over 70 years of research and industrial utilization. Herein, we describe the rational engineering of the publicly available RUT-C30 strain and a customized process for cellulase production based on agroindustrial by-products.

Results: A CRISPR/Cas9 system was used to introduce six genetic modifications in RUT-C30. Read More

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http://dx.doi.org/10.1186/s13068-020-01732-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243233PMC

METHODS FOR CARIES PREVENTION IN ADULTS AMONG DENTISTS FROM A BRAZILIAN COMMUNITY: Adult' caries prevention among Brazilian dentists.

Braz J Oral Sci 2020 ;19

Dental Practice-Based Research, University of Florida, College of Dentistry, Room D9-6 P.O. Box 100415, Gainesville, FL 32610-0415, The United States of America.

Little is known about dental practice patterns of caries prevention in adults among Brazilian dentists.

Objective: To quantify procedures used for caries prevention for adult patients among dentists from a Brazilian community.

Methods: Dentists (n=197) who reported that at least 10% of their patients are more than 18 years old participated in the first Brazilian study that used a translated version of the "Assessment of Caries Diagnosis and Caries Treatment" from the U. Read More

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http://dx.doi.org/10.20396/bjos.v19i0.8656224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252211PMC
January 2020

Prevalence of smoking, quit attempts and access to cessation treatment among adults with mental illness in Brazil: a cross-sectional analysis of a National Health Survey.

BMJ Open 2020 May 26;10(5):e033959. Epub 2020 May 26.

Department of Population Health, University of Kansas Medical Center, Kansas City, Kansas, USA.

Objectives: Determine the national prevalence of smoking and factors related to smoking among adults with mental illness (PLWMI; people living with mental illness) in Brazil.

Design: Cross-sectional study.

Setting: We used data from the nationally representative general health survey of 2013, which included the Global Adult Tobacco Survey (GATS) module. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033959DOI Listing

Polymorphisms in the heme oxygenase-1 and bone morphogenetic protein receptor type 1b genes and estimated glomerular filtration rate in Brazilian sickle cell anemia patients.

Hematol Transfus Cell Ther 2020 May 16. Epub 2020 May 16.

Faculdade de Ciências Médicas, Universidade Estadual de Campinas (FCM/UNICAMP), Campinas, SP, Brazil. Electronic address:

Introduction: Mutations affecting genes involved in oxidative and signaling pathways may be associated with kidney disease in sickle cell anemia. We determined the allele and genotype frequencies of some polymorphisms in the promoter regions of the Heme Oxygenase-1 (HMOX1) [rs2071746 (A>T) and (GT)n repeats, short (S) and long (L) alleles] and Bone Morphogenetic Protein Receptor type-1B (BMPR1B) [rs17022863 (A>G), rs4331783 (A>G) and rs1470409 (A>G)] genes in 75 adult patients with sickle cell anemia and 160 healthy controls and investigated whether these polymorphisms may influence the estimated glomerular filtration rate for the patients.

Methods: The single nucleotide polymorphisms were genotyped using the TaqMan assays, the HMOX1(GT)n repeats were determined by polymerase chain reaction fragment size analysis and the estimated glomerular filtration rate was calculated by the Modification of Diet in Renal Disease formula. Read More

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http://dx.doi.org/10.1016/j.htct.2020.01.009DOI Listing

Antiphospholipid Syndrome Committee of the Brazilian Society of Rheumatology position statement on the use of direct oral anticoagulants (DOACs) in antiphospholipid syndrome (APS).

Adv Rheumatol 2020 May 27;60(1):29. Epub 2020 May 27.

Disciplina de Reumatologia, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.

Background: The term Direct Oral Anticoagulants (DOACs) refers to a group of drugs that inhibit factor Xa or thrombin. Even though their use for treating different thrombotic or prothrombotic conditions is increasing recently, there is no compelling evidence indicating that those medications are safe in all antiphospholipid syndrome (APS) patients.

Methodology: To address this issue, specialists from the Antiphospholipid Syndrome Committee of the Brazilian Society of Rheumatology performed a comprehensive review of the literature regarding DOACs use in APS to answer the three following questions: (1) potential mechanisms of action of these drugs that could be relevant to APS pathogenesis, (2) DOACs interference on lupus anticoagulant testing, and (3) the efficacy of DOACs in APS. Read More

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http://dx.doi.org/10.1186/s42358-020-00125-9DOI Listing

CYP19A1 gene expression in the peripheral blood of Brazilian women with breast cancer relapse.

BMC Cancer 2020 May 27;20(1):480. Epub 2020 May 27.

Postgraduate Program of the Northeast Network of Biotechnology (RENORBIO), Teresina, Northeast, Brazil.

Background: The CYP19A1 gene, which encodes the enzyme responsible for androgen aromatization into estrogens, may play an important role in breast cancer aggressiveness. However, no study has evaluated CYP19A1 gene expression in the peripheral blood of women with relapsed breast cancer.

Methods: In this cross-sectional study, CYP19A1 gene expression was quantified by RT-PCR in the peripheral blood of 146 women with breast cancer who were first divided into two groups according to the expression of CYP19A1 (low and high); each group had 73 patients. Read More

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http://dx.doi.org/10.1186/s12885-020-06978-zDOI Listing

Behavioral Patterns with the Coexistence of Risk and Protective Factors for Cancer in Brazil.

Nutr Cancer 2020 May 28:1-8. Epub 2020 May 28.

Department of Nutrition, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

About one third of the most common cancers could be prevented by the reduction of modifiable behavioral risk factors. We aimed to identify behavioral patterns of risk and protective factors for cancer in Brazil, between 2014 and 2015. Data from Vigitel Survey ( 95,027 adults aged ≥ 18 years) from all Brazilian capitals and Federal District were used. Read More

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http://dx.doi.org/10.1080/01635581.2020.1769692DOI Listing

Brazilian berry extract (Myrciaria jaboticaba): A promising therapy to minimize prostatic inflammation and oxidative stress.

Prostate 2020 May 27. Epub 2020 May 27.

Department of Structural and Functional Biology, Institute of Biology, University of Campinas, São Paulo, Brazil.

Background: Brazilian berry is a fruit popularly known as "Jaboticaba," rich in bioactive compounds with antioxidant and anti-inflammatory properties. Senescence and overweight are increasing worldwide and are considered risk factors to prostatic pathogenesis mainly due to oxidative and inflammatory processes induction. Thus, this study aimed to evaluate the effect of two increasing doses of the patented jaboticaba peel extract (PJE) on oxidative-stress and inflammation in the prostate of aging or high-fat-fed aging mice. Read More

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http://dx.doi.org/10.1002/pros.24017DOI Listing

Brazilian oral medicine and oral pathology: we are here during the Covid-19 pandemic.

Oral Dis 2020 May 27. Epub 2020 May 27.

Department of Stomatology, A.C. Camargo Cancer Center, São Paulo, Brazil.

Coronavirus disease 19 (Covid-19) was declared a pandemic by the World Health Organization on March 11 , 2020 (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen). Read More

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http://dx.doi.org/10.1111/odi.13440DOI Listing

Pharmaceuticals and personal care products in a Brazilian wetland of international importance: Occurrence and environmental risk assessment.

Sci Total Environ 2020 May 14;734:139374. Epub 2020 May 14.

Post-Graduate Program in Technological and Environmental Chemistry, Escola de Química e Alimentos, Laboratório de Análise de Compostos Orgânicos e Metais (LACOM), Universidade Federal do Rio Grande, Av Itália, km 8, Rio Grande, RS 96201-900, Brazil. Electronic address:

Despite the fact that the occurrence of emerging contaminants in the environment has become frequent in recent decades, the seasonal dynamics of contaminants in different environmental compartments are little studied in protected areas influenced by effluent discharges. In this study, the seasonal and spatial occurrence of 33 pharmaceuticals and personal care products (PPCPs) was investigated in surface waters and sediments from Anil and Bacanga rivers (northeast of Brazil). The studied area is located within a Wetland of International Importance by Ramsar Convention (Amazon Estuary and its Mangroves). Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139374DOI Listing

Brazilian Dialysis Census: analysis of data from the 2009-2018 decade.

J Bras Nefrol 2020 May 20. Epub 2020 May 20.

Universidade Federal do Paraná, Curitiba, PR, Brasil.

Introduction: National data on chronic dialysis treatment are essential for the development of health policies that aim to improve patient treatment.

Objective: To present data from the Brazilian Society of Nephrology on patients with chronic dialysis for kidney disease in July 2018, making a comparative analysis of the past 10 years.

Methods: Data collection from dialysis units, with filling in an online questionnaire for 2018. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2019-0234DOI Listing

PERSPECTIVES: Insurance markets, labor markets, and the mental health services delivery system.

J Ment Health Policy Econ 2020 Mar;23(1):27-37

Department of Economical Sciences, School of Economical Sciences, Universidade Federal de Minas Gerais (UFMG), Av. Presidente Antonio Carlos, 6627, Pampulha 31.270-901, Belo Horizonte, Brazil,

Background: Schizophrenia is a chronic debilitating condition characterized by disorders in thought, affect and behavior. Considering the low effectiveness of antipsychotic drugs for schizophrenia and the potentially high cost of an inadequate choice, a systematic cost-effectiveness evaluation of the list of subsidized antipsychotic drugs is necessary in order to allow an adequate choice of pharmacotherapy for the patient and the financial reality of the Brazilian public health system (SUS).

Objective: The aims of this study are to conduct a cost-effectiveness analysis of the subsidized antipsychotic drugs for the first-line treatment of schizophrenia in Brazil and aripiprazole, and to discuss a reasonable incorporation price for aripiprazole. Read More

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Faith, Family, and Social Networks: Effective Strategies for Recruiting Brazilian Immigrants in Maternal and Child Health Research.

J Racial Ethn Health Disparities 2020 May 26. Epub 2020 May 26.

Department of Health Studies, University of Rhode Island, Kingston, RI, USA.

Participation of racial/ethnic minority and immigrant populations in research studies is essential to understand and address health disparities. Nonetheless, these populations are often underrepresented in research because of limited participation that may be due to barriers to participation such as fear and mistrust of research, lack of or limited access to healthcare and social services, time and employment constraints, participation-associated costs (e.g. Read More

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http://dx.doi.org/10.1007/s40615-020-00753-3DOI Listing

Psychiatric symptoms are frequent in idiopathic intracranial hypertension patients.

Neurosurg Rev 2020 May 26. Epub 2020 May 26.

Group of Cerebral Hydrodynamics, Division of Functional Neurosurgery, Institute of Psychiatry, Hospital das Clínicas, University of São Paulo, São Paulo, Brazil.

Idiopathic intracranial hypertension (IIH) is a rare disease with an incidence rate of 0.5-2.0/100,000/year. Read More

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http://dx.doi.org/10.1007/s10143-020-01321-3DOI Listing

Correction to: Diagnosis of Cutaneous Melanoma: the Gap between the Knowledge of General Practitioners and Dermatologists in a Brazilian Population.

J Cancer Educ 2020 May 27. Epub 2020 May 27.

School of Medicine, Faculdade Ciências Médicas de Minas Gerais, Alameda Ezequiel Dias 275, Belo Horizonte, 30130-110, Brazil.

The original version of this article unfortunately contained a mistake. The name of "Carolina Ledsham" is now corrected in the author group of this article. Read More

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http://dx.doi.org/10.1007/s13187-020-01774-6DOI Listing

Inequalities in birth weight and maternal education: a time-series study from 1996 to 2013 in Brazil.

Sci Rep 2020 May 26;10(1):8707. Epub 2020 May 26.

Research and Graduate Studies Group, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, 90035-007, Brazil.

Maternal education represents one of the most important social determinants of inequality in birth weight (BW) in developing countries. The present study sought to investigate secular trends in health inequality considering the difference in mean BW between extremes of maternal educational attainment in Brazil. Using a time-series design, data from 6,452,551 live births which occurred in all Brazilian state capitals from 1996 to 2013 were obtained from the Information System on Live Births. Read More

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http://dx.doi.org/10.1038/s41598-020-65445-8DOI Listing

Bothrops atrox Snakebite: How a Bad Decision May Lead to a Chronic Disability: A Case Report.

Wilderness Environ Med 2020 May 24. Epub 2020 May 24.

Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil; Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Amazonas, Brazil.

Snakebites are a neglected and underestimated global health hazard. In the Brazilian Amazon, Bothrops snakebites are the most prevalent and may lead to severe complications. Here we describe a severe case of Bothrops atrox snakebite that, owing to delayed medical assistance, presented with renal and respiratory failure, compartment syndrome, and tissue necrosis. Read More

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http://dx.doi.org/10.1016/j.wem.2020.03.001DOI Listing

Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil.

BMC Infect Dis 2020 May 26;20(1):373. Epub 2020 May 26.

ESPACE-DEV, IRD, Universités de Montpellier, de La Réunion, de la Guyane, des Antilles, Montpellier, France: LIS, ICICT, Fiocruz, Av. Brasil, 4365, Manguinhos, Rio de Janeiro, Brazil.

Background: In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017.

Methods: Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Read More

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http://dx.doi.org/10.1186/s12879-020-05086-4DOI Listing

Multilocus sequence typing characterizes diversity of Ureaplasma diversum strains, and intra-species variability induces different immune response profiles.

BMC Vet Res 2020 May 26;16(1):163. Epub 2020 May 26.

Universidade Estadual de Santa Cruz, Brazil, Jorge Amado Highway, Km 16, Salobrinho, Ilheus, Bahia, 45662-900, Brazil.

Background: Ureaplasma diversum is a pathogen found in the genital tract of cattle and associated with genital disorders such as infertility, placentitis, abortion, birth of weak calves, low sperm motility, seminal vesiculitis and epididymitis. There are few studies evaluating the genetic diversity of U. diversum strains and their influence on the immune response in cattle. Read More

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http://dx.doi.org/10.1186/s12917-020-02380-wDOI Listing

Gender Affirmation Is Associated with Transgender and Gender Nonbinary Youth Mental Health Improvement.

LGBT Health 2020 May 25. Epub 2020 May 25.

Postgraduate Program in Psychology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.

The present study aimed to evaluate the impact of each domain of gender affirmation (social, legal, and medical/surgical) on the mental health of transgender and gender nonbinary youth. Three hundred fifty transgender boys, transgender girls, and gender nonbinary Brazilian youth, from 16 to 24 years old, answered an online survey. The final sample consisted of 350 youth who participated in this study. Read More

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http://dx.doi.org/10.1089/lgbt.2019.0046DOI Listing

Phylogeny of () (Diptera: Culicidae) Using Mitochondrial Genes.

Insects 2020 May 24;11(5). Epub 2020 May 24.

Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, SP 01246-904, Brazil.

Identification of mosquito species is necessary for determining the entomological components of malaria transmission, but it can be difficult in morphologically similar species. DNA sequences are largely used as an additional tool for species recognition, including those that belong to species complexes. mosquitoes are vectors of human and simian malaria in the Neotropical Region, but there are few DNA sequences of species in public databases. Read More

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http://dx.doi.org/10.3390/insects11050324DOI Listing

The Action of JAK/STAT3 and BMP/HJV/SMAD Signaling Pathways on Hepcidin Suppression by Tucum-do-Cerrado in a Normal and Iron-Enriched Diets.

Nutrients 2020 May 22;12(5). Epub 2020 May 22.

Postgraduate Program in Human Nutrition, Faculty of Health Sciences, Campus Universitário Darcy Ribeiro, Universidade de Brasília, Brasília 70910-900, Brazil.

The Brazilian savanna fruit, tucum-do-cerrado ( Mart.) reduces hepatic hepcidin levels. Therefore, we investigated the effect of tucum-do-cerrado on the TfR/HFE and/or BMP/HJV/SMAD and JAK/STAT pathways, in normal and excess iron conditions. Read More

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http://dx.doi.org/10.3390/nu12051515DOI Listing

Assessing the Mental Health of Brazilian Students Involved in Risky Behaviors.

Int J Environ Res Public Health 2020 May 22;17(10). Epub 2020 May 22.

Public Health, Instituto Federal Goiano-Campus Ceres, Ceres 76300-000, Brazil.

Adolescence, which is the transition from childhood to adulthood, is marked by emotional sensitivity and inconsistency and may be affected by mental health problems. In order to fill the gap related to the risky behaviors in students in Brazil, our cross-sectional study aimed to analyze the relationship between risky behaviors and indicators of mental health of Brazilian students. We used the data from the National School Health Survey to analyze the relationship between risk behaviors and three symptoms of mental health issues: feeling of being alone, number of close friends, and trouble sleeping due to worries. Read More

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http://dx.doi.org/10.3390/ijerph17103647DOI Listing

Social-Ecological Correlates of Regular Leisure-Time Physical Activity Practice among Adults.

Int J Environ Res Public Health 2020 May 21;17(10). Epub 2020 May 21.

Department of Sport Science, State University of Londrina, Londrina 86057-970, Brazil.

This study calculated the exposure-response rates of social-ecological correlates of practicing regular (>150 min/week) leisure-time physical activity (PA) in 393,648 adults from the 27 Brazilian state capitals who participated in a national survey between 2006 and 2016. Regular PA encouraging factors were inputted into an exposure-response model. Growth rates for the odds ratio and prevalence of regular PA were calculated for each increase of one encouraging factor. Read More

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http://dx.doi.org/10.3390/ijerph17103619DOI Listing

Effects of Extra Virgin Olive Oil (EVOO) and the Traditional Brazilian Diet on Sarcopenia in Severe Obesity: A Randomized Clinical Trial.

Nutrients 2020 May 21;12(5). Epub 2020 May 21.

Department of Epidemiology & Public Health, University College London, London WC1E 6BT, UK.

Background: Nutritional interventions may have positive effects on sarcopenia and body composition.

Objective: to evaluate the effectiveness of extra virgin olive oil (EVOO) consumption and a healthy traditional Brazilian diet (DieTBra) on improving sarcopenia indicators and reducing total body fat in severe obesity.

Methods: A randomized controlled trial registered at ClinicalTrials. Read More

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http://dx.doi.org/10.3390/nu12051498DOI Listing

Effects of Cashew Nut ( L.) Seed Flour in Moderately Malnourished Children: Randomized Clinical Trial.

J Nutr Metab 2020 4;2020:6980754. Epub 2020 May 4.

Health Sciences Institute, University for International Integration of the Afro-Brazilian Lusophony, José Franco de Oliveira Street, S/N, Redenção, CE, Brazil.

The monitoring and combined use of dietary supplements to restore adequate growth are paramount and highly recommended in child malnutrition, an important public health problem. The objective of this study was to analyze the effects of cashew nut seed flour in children with moderate malnutrition, treated at primary healthcare services. This is a randomized clinical trial conducted from April to October 2017 in the city of Imperatriz, Brazil. Read More

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http://dx.doi.org/10.1155/2020/6980754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222489PMC

Antifungal activity of Brazilian red propolis extract and isolation of bioactive fractions by thin-layer chromatography-bioautography.

Food Chem 2020 May 18;327:127060. Epub 2020 May 18.

CIRAD, UMR Qualisud, F-34398 Montpellier, France. Electronic address:

Objectives: This study set out to highlight the in vitro and in vivo antifungal activity of an Ethanolic Extract of Red Brazilian Propolis (EERBP) and identify bioactive fractions effective against Colletotrichum musae.

Methods: Active fractions were detected by the thin-layer chromatography-bioautography method and characterised by HPLC-MS.

Results: The in vitro results showed that EERBP had strong antifungal properties againstC. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127060DOI Listing

Characterization of honey of stingless bees from the Brazilian semi-arid region.

Food Chem 2020 May 16;327:127041. Epub 2020 May 16.

Universidade Federal da Bahia, Instituto de Ciências Tecnologia e Inovação, Campus Universitário de Camaçari, 42809-000 Camaçari, Bahia, Brazil. Electronic address:

The physicochemical characteristics of honey vary according to bee species, climate, region, period of collection, processing and storage. In this context, this work aimed to perform a comparative study of the physicochemical characteristics of Melipona subnitida and M. fasciculata honey collected at different periods and regions of the State of Piauí, Brazil. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127041DOI Listing

Variants in HSD11B1 gene modulate susceptibility to diabetes kidney disease and to insulin resistance in type 1 diabetes individuals.

Diabetes Metab Res Rev 2020 May 26:e3352. Epub 2020 May 26.

SP, Brazil.

Background And Aim: 11β-hydroxysteroid dehydrogenase 1 (11βHSD1) has been implicated in insulin resistance (IR) in the setting of metabolic disorders, and single nucleotide polymorphisms (SNPs) in its encoding gene (HSD11B1) have been associated with type 2 diabetes and metabolic syndrome. In type 1 diabetes (T1D), IR has been related to the development of chronic complications. We investigated the association of HSD11B1 SNPs with microvascular complications and with IR in a Brazilian cohort of T1D individuals. Read More

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http://dx.doi.org/10.1002/dmrr.3352DOI Listing

Haplotypic characterization of BRCA1 c.5266dupC, the prevailing mutation in Brazilian hereditary breast/ovarian cancer.

Genet Mol Biol 2020 20;43(2):e20190072. Epub 2020 May 20.

Instituto Nacional de Câncer, Programa de Genética, Rio de Janeiro, RJ, Brazil.

Specific pathogenic mutations associated with breast cancer development can vary between ethnical groups. One example is BRCA1 c.5266dupC that was first described as a founder mutation in the Ashkenazi Jewish population, but was later also found in other populations. Read More

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http://dx.doi.org/10.1590//1678-4685-GMB-2019-0072DOI Listing

Pharmacogenomics of thiopurines: distribution of TPMT and NUDT15 polymorphisms in the Brazilian Amazon.

Pharmacogenet Genomics 2020 May 22. Epub 2020 May 22.

Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro.

Reduced function alleles in the TPMT and NUDT15 genes are risk factors for thiopurine toxicity. This study evaluated the influence of Native ancestry on the distribution of TPMT (rs1142345, rs1800460 and rs1800462) and NUDT15 (rs116855232) polymorphisms and compound metabolic phenotypes in 128 healthy males from the Brazilian Amazon. The average proportion of Native and European ancestry differed greatly and significantly between self-declared Amerindians and non-Amerindians, although extensive admixture in both groups was evident. Read More

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http://dx.doi.org/10.1097/FPC.0000000000000411DOI Listing

Vulnerable Immigrant Populations in the New York Metropolitan Area and COVID-19: Lessons Learned in the Epicenter of the Crisis.

Acad Med 2020 May 22. Epub 2020 May 22.

S. Behbahani is a third-year student, Rutgers New Jersey Medical School, Newark, New Jersey; ORCID: http://orcid.org/0000-0001-9159-4745. C.A. Smith is a lawyer and first-year student, Rutgers New Jersey Medical School, Newark, New Jersey. M. Carvalho is an incoming nursing student, Rutgers School of Nursing, Newark, New Jersey. C.J. Warren is a third-year student, Rutgers New Jersey Medical School, Newark, New Jersey. M. Gregory is a nurse and project coordinator, West Virginia Prevention Research Center, School of Public Health, West Virginia University, Morgantown, West Virginia. N.A. Silva is a recent graduate, Rutgers New Jersey Medical School, Newark, New Jersey, and incoming postgraduate year 1 neurosurgery resident, University of North Carolina, Chapel Hill, North Carolina.

The epicenter of the COVID-19 crisis since March 17, 2020-the New York metropolitan area-is home to some of the largest Latino immigrant communities in the nation. These communities have long faced barriers to health care access, challenges due to immigration status, and financial and labor instability. The COVID-19 pandemic has aggravated these existing issues in a vulnerable, often forgotten, immigrant community. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003518DOI Listing
May 2020
2.934 Impact Factor

Use of whole-body cryosectioning and desorption electrospray ionization mass spectrometry imaging to visualize alkaloid distribution in poison frogs.

J Mass Spectrom 2020 Jun;55(6):e4520

Center for Research in Mass Spectrometry, Department of Chemistry, York University, Toronto, Ontario, Canada.

Ambient mass spectrometry is useful for analyzing compounds that would be affected by other chemical procedures. Poison frogs are known to sequester alkaloids from their diet, but the sequestration pathway is unknown. Here, we describe methods for whole-body cryosectioning of frogs and use desorption electrospray ionization mass spectrometry imaging (DESI-MSI) to map the orally administered alkaloid histrionicotoxin 235A in a whole-body section of the poison frog Dendrobates tinctorius. Read More

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http://dx.doi.org/10.1002/jms.4520DOI Listing

Screening of plants from the Brazilian Atlantic Forest led to the identification of Athenaea velutina (Solanaceae) as a novel source of antimetastatic agents.

Int J Exp Pathol 2020 May 26. Epub 2020 May 26.

Departamento de Bioquímica e Biologia Molecular, Universidade Federal de Viçosa, Minas Gerais, Brazil.

Plant biodiversity is a source of potential natural products for the treatment of many diseases. One of the ways of discovering new drugs is through the cytotoxic screening of extract libraries. The present study evaluated 196 extracts prepared by maceration of Brazilian Atlantic Forest trees with organic solvents and distilled water for cytotoxic and antimetastatic activity. Read More

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http://dx.doi.org/10.1111/iep.12351DOI Listing

Development of algorithms to estimate EQ-5D and derive health utilities from WHOQOL-HIV Bref: a mapping study.

Qual Life Res 2020 May 25. Epub 2020 May 25.

Fundação Oswaldo Cruz, FIOCRUZ, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brazil.

Purpose: This study aimed to develop and evaluate different families of applicable models available for utility mapping between World Health Organization Quality of Life for HIV-abbreviated version (WHOQOL-HIV Bref) and EQ-5D-3L and to propose an optimised algorithm to estimate health utilities of people living with HIV.

Methods: Estimation dataset was collected between July 2014 and September 2016 in a cross-sectional study including 1526 people living with HIV/Aids (PLWH) under care at the Instituto Nacional de Infectologia Evandro Chagas-FIOCRUZ, in Brazil. Data of WHOQOL-HIV Bref and EQ-5D-3L questionnaires were collected. Read More

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http://dx.doi.org/10.1007/s11136-020-02534-1DOI Listing

Sugarcane production and climate trends in Paraíba state (Brazil).

Environ Monit Assess 2020 May 26;192(6):392. Epub 2020 May 26.

Center of Alternative and Renewable Energy, Federal University of Paraíba (UFPB), Joao Pessoa, Paraíba, 58051-900, Brazil.

Statistical surveys to detect trends in time series are fundamental tools to evaluate farming dynamics of sugarcane and of adaptation plans for possible impacts caused by climate change. This work analyzed the influence of climate change in the cultivation of sugarcane in the state of Paraíba (Northeast Brazil), in order to investigate what are the consequences of temperature increase, air humidity level, and changes in the precipitation regime forecasted for the region in sugarcane farming. Data of temperature, total precipitation, and relative humidity of six meteorological stations kept by the Brazilian National Institute of Meteorology (INMET) spread across the state of Paraíba and data from the area of sugarcane harvesting from the Brazilian Institute of Geography and Statistics (IBGE). Read More

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http://dx.doi.org/10.1007/s10661-020-08358-3DOI Listing

Structural insights into β-1,3-glucan cleavage by a glycoside hydrolase family.

Nat Chem Biol 2020 May 25. Epub 2020 May 25.

Brazilian Biorenewables National Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, São Paulo, Brazil.

The fundamental and assorted roles of β-1,3-glucans in nature are underpinned on diverse chemistry and molecular structures, demanding sophisticated and intricate enzymatic systems for their processing. In this work, the selectivity and modes of action of a glycoside hydrolase family active on β-1,3-glucans were systematically investigated combining sequence similarity network, phylogeny, X-ray crystallography, enzyme kinetics, mutagenesis and molecular dynamics. This family exhibits a minimalist and versatile (α/β)-barrel scaffold, which can harbor distinguishing exo or endo modes of action, including an ancillary-binding site for the anchoring of triple-helical β-1,3-glucans. Read More

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http://dx.doi.org/10.1038/s41589-020-0554-5DOI Listing

Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa.

Commun Biol 2020 May 25;3(1):263. Epub 2020 May 25.

Biochemistry & Biomedicine, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK.

Moniliophthora perniciosa is a fungal pathogen and causal agent of the witches' broom disease of cocoa, a threat to the chocolate industry and to the economic and social security in cocoa-planting countries. The membrane-bound enzyme alternative oxidase (MpAOX) is crucial for pathogen survival; however a lack of information on the biochemical properties of MpAOX hinders the development of novel fungicides. In this study, we purified and characterised recombinant MpAOX in dose-response assays with activators and inhibitors, followed by a kinetic characterization both in an aqueous environment and in physiologically-relevant proteoliposomes. Read More

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http://dx.doi.org/10.1038/s42003-020-0981-6DOI Listing