6,444 results match your criteria Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas[Journal]


Sepsis: evolving concepts and challenges.

Braz J Med Biol Res 2019 15;52(4):e8595. Epub 2019 Apr 15.

Disciplina de Infectologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden in low- and middle-resource settings. The role of the inflammatory response in the pathogenesis of the syndrome has supported the modern concept of sepsis. Nevertheless, a definition of sepsis and the criteria for its recognition is a continuous process, which reflects the growing knowledge of its mechanisms and the success and failure of diagnostic and therapeutic interventions. Read More

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http://dx.doi.org/10.1590/1414-431X20198595DOI Listing
April 2019
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Altered peripheral lymphocyte subsets in untreated systemic lupus erythematosus patients with infections.

Braz J Med Biol Res 2019 15;52(4):e8131. Epub 2019 Apr 15.

Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, People's Republic of China.

The leading cause of death in systemic lupus erythematosus (SLE) patients is infection. The objective of this study was to evaluate the distribution of lymphocyte subsets in untreated SLE patients with infections. This was a cross-sectional study. Read More

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http://dx.doi.org/10.1590/1414-431X20198131DOI Listing

Egocentric and allocentric spatial memory in healthy aging: performance on real-world tasks.

Braz J Med Biol Res 2019 15;52(4):e8041. Epub 2019 Apr 15.

Department of Psychology, University of Oviedo, Oviedo, Spain.

Although normal aging has been related to several cognitive difficulties, other processes have been studied less, such as spatial memory. Our aim was to compare egocentric and allocentric memory in an elderly population using ecological tasks. Twenty-eight cognitively unimpaired participants performed Egocentric and Allocentric Spatial Memory Tasks, as well as Spatial Span from CANTAB, Benton's Judge of Line Orientation test (JoLO), and Montreal Cognitive Assessment test (MoCA). Read More

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http://dx.doi.org/10.1590/1414-431X20198041DOI Listing
April 2019
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Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells.

Braz J Med Biol Res 2019 15;52(4):e7728. Epub 2019 Apr 15.

Department of Pain Clinic, The First Affiliated Hospital of Xiamen University, Fujian Medical University, Xiamen, Fujian, China.

Pituitary adenoma is one of the most common tumors in the neuroendocrine system. This study investigated the effects of long non-coding RNAs (lncRNAs) highly up-regulated in liver cancer (HULC) on rat secreting pituitary adenoma GH3 cell viability, migration, invasion, apoptosis, and hormone secretion, as well as the underlying potential mechanisms. Cell transfection and qRT-PCR were used to change and measure the expression levels of HULC, miR-130b, and FOXM1. Read More

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http://dx.doi.org/10.1590/1414-431X20197728DOI Listing
April 2019
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Hydrogen sulfide protects H9c2 cardiomyoblasts against H2O2-induced apoptosis.

Braz J Med Biol Res 2019 15;52(4):e7626. Epub 2019 Apr 15.

Department of Intensive Care Unit, Renmin Hospital, Hubei University of Medicine, Shiyan, China.

Reactive oxygen species (ROS) are highly reactive chemical species that may cause irreversible tissue damage, and play a critical role in cardiovascular diseases. Hydrogen sulfide (H2S) is a gasotransmitter that acts as a ROS scavenger with cardio-protective effects. In this study, we investigated the cytoprotective effect of H2S against H2O2-induced apoptosis in cardiomyocytes. Read More

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http://dx.doi.org/10.1590/1414-431X20187626DOI Listing

Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells.

Braz J Med Biol Res 2019 Apr 8;52(4):e8409. Epub 2019 Apr 8.

Department of Stomatology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Benzyl isothiocyanate (BITC) has been shown to inhibit invasion and induce apoptosis of various types of cancer. However, its role on human oral squamous cell carcinoma (OSCC) cells is still not well elucidated. In the present study, we investigated the effect of BITC on apoptosis and invasion of SCC9 cells, and its underlying mechanisms in vitro and in vivo. Read More

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http://dx.doi.org/10.1590/1414-431X20198409DOI Listing
April 2019
2 Reads

Association between varicose veins anatomical pattern and procedural complications following endovascular laser photothermolysis for chronic venous insufficiency.

Braz J Med Biol Res 2019 Apr 8;52(4):e8330. Epub 2019 Apr 8.

TopMed Medical Center, Tîrgu Mureş, Romania.

We sought to assess clinical characteristics and pattern of collateral network involvement associated with development of truncal (systematized) versus diffuse/non-truncal (non-systematized) varicose veins (VVs) in patients undergoing endovascular laser photothermolysis for chronic venous insufficiency (CVI). Secondly, we aimed to assess whether the type of VVs influenced the procedural complications of endovascular laser therapy. A total of 508 patients with hydrostatic VVs of the lower limbs who underwent endovenous laser treatment were included, out of which 84. Read More

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http://dx.doi.org/10.1590/1414-431X20198330DOI Listing
April 2019
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Genetic correlation between Prothrombin G20210A polymorphism and retinal vein occlusion risk.

Braz J Med Biol Res 2019 Apr 8;52(4):e8217. Epub 2019 Apr 8.

Department of Refraction and Cornea, Tianjin Medical University Eye Hospital, School of Optometry and Ophthalmology, Tianjin Medical University, Tianjin, China.

The aim of this study was to perform an updated meta-analysis to quantitatively investigate the association between G20210A polymorphism of Prothrombin gene and the risk of retinal vein occlusion (RVO), based on the available publications with inconsistent results. We utilized the Stata software to perform the heterogeneity test, association test, Begg's and Egger's tests, and sensitivity analysis. We searched three on-line databases (PubMed, Embase, and WOS) and obtained a total of 422 articles. Read More

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http://dx.doi.org/10.1590/1414-431X20198217DOI Listing

Plasma brain-derived neurotrophic factor is higher after combat training (Randori) than incremental ramp test in elite judo athletes.

Braz J Med Biol Res 2019 Apr 8;52(4):e8154. Epub 2019 Apr 8.

Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Elite judo demands high levels of physical and psychological skills. The brain-derived neurotrophic factor (BDNF) may be of particular interest in sports medicine for its ability to promote neuroplasticity. We investigated the plasma BDNF before and after a judo training session (Randori) and the maximal incremental ramp test (MIRT) in athletes from the Brazilian national judo team and compared the results between both exercise stimuli and sexes. Read More

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http://dx.doi.org/10.1590/1414-431X20198154DOI Listing

Baroreflex sensitivity in frailty syndrome.

Braz J Med Biol Res 2019 Apr 8;52(4):e8079. Epub 2019 Apr 8.

Departamento de Fisioterapia, Universidade Federal de São Carlos, São Carlos, SP, Brasil.

Frailty is related to a decrease in the physiological reserves, which causes difficulties in maintaining homeostasis. An example of physiological mechanisms for cardiovascular homeostasis is the baroreflex. The aim of this study was to compare baroreflex among frail, prefrail, and nonfrail individuals, in supine and orthostatic positions. Read More

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http://dx.doi.org/10.1590/1414-431X20198079DOI Listing
April 2019
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Diagnostic accuracy of thromboelastometry and its correlation with the HPLC-MS/MS quantification test.

Braz J Med Biol Res 2019 Apr 8;52(4):e8006. Epub 2019 Apr 8.

Hospital Israelita Albert Einstein, São Paulo, SP, Brasil.

The aim of the study was to evaluate the diagnostic accuracy of thromboelastometry for assessing rivaroxaban concentrations. The accuracy of thromboelastometry was compared with the high-performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method, which is the gold standard for drug plasma monitoring (the reference standard). Forty-six clinically stable patients were treated with 10, 15, or 20 mg of rivaroxaban once daily (OD group) or 15 mg twice a day (BID group) (no particular indication for treatment). Read More

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http://dx.doi.org/10.1590/1414-431X20198006DOI Listing
April 2019
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Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Braz J Med Biol Res 2019 Apr 8;52(4):e7546. Epub 2019 Apr 8.

Department of Gynecology and Obstetrics, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Preeclampsia is a major reason of morbidity and mortality in pregnant women and perinatal fetus. Hence, it is of prime importance that diagnostic markers are defined to predict chances of preeclampsia in pregnant women. It has been previously shown that microRNA (miRNA)-376c expression is decreased in the placenta of preeclampsia patients at term. Read More

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http://dx.doi.org/10.1590/1414-431X20197546DOI Listing
April 2019
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Burden, access, and disparities in kidney disease.

Braz J Med Biol Res 2019 Mar 25;52(3):e8338. Epub 2019 Mar 25.

Nephrology Unit, Department of Internal Medicine, Faculty of Medicine, Cairo University, Giza, Egypt.

This article was published in Kidney International volume 95, pages 242-248, https://doi.org/10.1016/j. Read More

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http://dx.doi.org/10.1590/1414-431X20198338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437937PMC
March 2019
1 Read

Effects of artepillin C on model membranes displaying liquid immiscibility.

Braz J Med Biol Res 2019 Mar 25;52(3):e8281. Epub 2019 Mar 25.

Departmento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

It has been hypothesized that the therapeutic effects of artepillin C, a natural compound derived from Brazilian green propolis, are likely related to its partition in the lipid bilayer component of biological membranes. To test this hypothesis, we investigated the effects of the major compound of green propolis, artepillin C, on model membranes (small and giant unilamelar vesicles) composed of ternary lipid mixtures containing cholesterol, which display liquid-ordered (lo) and liquid-disordered (ld) phase coexistence. Specifically, we explored potential changes in relevant membrane parameters upon addition of artepillin C presenting both neutral and deprotonated states by means of small angle X-ray scattering (SAXS), differential scanning calorimetry (DSC), and confocal and multiphoton excitation fluorescence microscopy. Read More

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http://dx.doi.org/10.1590/1414-431X20198281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437936PMC

Rapid, specific, and sensitive detection of the ureR_1 gene in Klebsiella pneumoniae by loop-mediated isothermal amplification method.

Braz J Med Biol Res 2019 Mar 25;52(3):e8186. Epub 2019 Mar 25.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China.

Klebsiella pneumoniae is one of the main pathogenic bacteria that causes nosocomial infections, such as pneumonia, urinary tract infection, and sepsis. Therefore, the rapid and accurate detection of K. pneumoniae is important for the timely treatment of infectious patients. Read More

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http://dx.doi.org/10.1590/1414-431X20198186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437934PMC
March 2019
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Prognostic factors in patients undergoing early-start peritoneal dialysis within 24 h after catheter insertion.

Braz J Med Biol Res 2019 Mar 25;52(3):e8055. Epub 2019 Mar 25.

Department of Nephrology, The Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province, China.

This study aimed to investigate the clinical characteristics, prognosis, and factors for survival of patients who underwent early-start peritoneal dialysis (PD) within 24 h after catheter insertion three years after PD. This study was conducted from January 1, 2013 to December 31, 2017. All adult patients who were diagnosed with end-stage renal disease (ESRD) and underwent PD for the first time within 24 h after catheter insertion in our hospital were included. Read More

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http://dx.doi.org/10.1590/1414-431X20188055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437961PMC
March 2019
2 Reads
1.034 Impact Factor

Association between tumor necrosis factor polymorphisms and rheumatoid arthritis as well as systemic lupus erythematosus: a meta-analysis.

Braz J Med Biol Res 2019 Mar 25;52(3):e7927. Epub 2019 Mar 25.

Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Tumor necrosis factor-alpha (TNF-α) plays an important role in autoimmune diseases. Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). However, no agreed conclusion had been made. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20187927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437938PMC
March 2019
4 Reads

Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation.

Braz J Med Biol Res 2019 Feb 25;52(3):e8251. Epub 2019 Feb 25.

Departamento de Fisiologia e Famacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Brasil.

Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti-inflammatory potential. Read More

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http://dx.doi.org/10.1590/1414-431X20188251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393848PMC
February 2019
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Effect of risperidone on proliferation and apoptosis of MC3T3-E1 cells.

Braz J Med Biol Res 2019 Feb 25;52(3):e8098. Epub 2019 Feb 25.

Department of Psychiatry, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

This aim of this study was to assess the molecular mechanism of osteoporosis in schizophrenia patients with risperidone use. Here, we investigated the effects of risperidone on cellular proliferation and apoptosis of a preosteoblast cell line, MC3T3-E1. Cell viability and apoptotic rate of MC3T3-E1 were detected by cell counting kit-8 and flow cytometry at a serial dose of risperidone and at different time points, respectively. Read More

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http://dx.doi.org/10.1590/1414-431X20188098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393850PMC
February 2019
1 Read
1.034 Impact Factor

Visual and automatic classification of the cyclic alternating pattern in electroencephalography during sleep.

Braz J Med Biol Res 2019 Feb 25;52(3):e8059. Epub 2019 Feb 25.

LaSEEB - Evolutionary Systems and Biomedical Engineering Laboratory, Institute for Systems and Robotics (ISR-Lisboa), Instituto Superior Técnico (IST), University of Lisbon, Lisbon, Portugal.

Cyclic alternating pattern (CAP) is a neurophysiological pattern that can be visually scored by international criteria. The aim of this study was to verify the feasibility of visual CAP scoring using only one channel of sleep electroencephalogram (EEG) to evaluate the inter-scorer agreement in a variety of recordings, and to compare agreement between visual scoring and automatic scoring systems. Sixteen hours of single-channel European data format recordings from four different sleep laboratories with either C4-A1 or C3-A2 channels and with different sampling frequencies were used in this study. Read More

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http://dx.doi.org/10.1590/1414-431X20188059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393849PMC
February 2019
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Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression.

Braz J Med Biol Res 2019 Feb 25;52(3):e7994. Epub 2019 Feb 25.

Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China.

Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Read More

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http://dx.doi.org/10.1590/1414-431X20187994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393853PMC
February 2019
1 Read

Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats.

Braz J Med Biol Res 2019 Feb 25;52(3):e7905. Epub 2019 Feb 25.

Department of Anesthesiology, Shenzhen People's Hospital, Shenzhen Anesthesiology Engineering Center, the Second Clinical Medical College, Jinan University, Shenzhen, China.

Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of hemorrhage/resuscitation (HS) and subsequent endotoxemia. Eighty Wistar rats were randomized into four groups: NS (normal saline), HS/L (HS plus lipopolysaccharide), HS/L+D (HS/L plus dexmedetomidine), and HS/L+D+Y (HS/L+D plus yohimbine). Read More

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http://dx.doi.org/10.1590/1414-431X20187905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393854PMC
February 2019
1 Read

Observation of the effect of bone marrow mesenchymal stem cell transplantation by different interventions on cirrhotic rats.

Braz J Med Biol Res 2019 Feb 25;52(3):e7879. Epub 2019 Feb 25.

Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China.

Bone marrow mesenchymal stem cells (BMSCs) transplantation has attracted attention for the treatment of liver cirrhosis and end-stage liver diseases. Therefore, in this study, we evaluated the effect of different methods of BMSCs transplantation in the treatment of liver cirrhosis in rats. Seventy-two male Sprague-Dawley rats were divided into 7 groups: 10 were used to extract BMSCs, 10 were used as normal group, and the remaining 52 rats were randomly divided into five groups for testing: control group, BMSCs group, BMSCs+granulocyte colony-stimulating factor (G-CSF) group, and BMSCs+Jisheng Shenqi decoction (JSSQ) group. Read More

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http://dx.doi.org/10.1590/1414-431X20187879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393847PMC
February 2019
2 Reads

Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Authors:
I M Bensenor

Braz J Med Biol Res 2019 Feb 14;52(2):e8417. Epub 2019 Feb 14.

Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.

Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests. Read More

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http://dx.doi.org/10.1590/1414-431X20198417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376318PMC
February 2019
1 Read

Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications.

Braz J Med Biol Res 2019 Feb 14;52(2):e8209. Epub 2019 Feb 14.

Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha, Vila Velha, ES, Brasil.

Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264. Read More

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http://dx.doi.org/10.1590/1414-431X20188209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376324PMC
February 2019

Pre-analytical parameters associated with unsuccessful karyotyping in myeloid neoplasm: a study of 421 samples.

Braz J Med Biol Res 2019 Feb 14;52(2):e8194. Epub 2019 Feb 14.

Hospital Israelita Albert Einstein, São Paulo, SP, Brasil.

Cytogenetics is essential in myeloid neoplasms (MN) and pre-analytical variables are important for karyotyping. We assessed the relationship between pre-analytical variables (time from collection to sample processing, material type, sample cellularity, and diagnosis) and failures of karyotyping. Bone marrow (BM, n=352) and peripheral blood (PB, n=69) samples were analyzed from acute myeloid leukemia (n=113), myelodysplastic syndromes (n=73), myelodysplastic syndromes/myeloproliferative neoplasms (n=17), myeloproliferative neoplasms (n=137), and other with conclusive diagnosis (n=6), and reactive disorders/no conclusive diagnosis (n=75). Read More

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http://dx.doi.org/10.1590/1414-431X20188194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376323PMC
February 2019
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Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity.

Braz J Med Biol Res 2019 Feb 14;52(2):e7988. Epub 2019 Feb 14.

Neuroscience Division, National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra", Col. Arenal de Guadalupe, Delegacion Tlalpan, Mexico City, Mexico.

Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal regeneration but there are also reports of it causing restriction, so it is important to clarify these divergent findings in order to understand the direct scope and side effects of potential pharmacological treatments. We evaluated the effect of serotonin on the extent of neuritic outgrowth and morphology of three different neuronal types in the leech Haementeria officinalis during their regeneration in vitro: Retzius interneurons (Rz), annulus erector (AE) motoneurons, and anterolateral number 1 (AL1) CNS neurons. Read More

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http://dx.doi.org/10.1590/1414-431X20187988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376320PMC
February 2019

Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis.

Authors:
Fan Zhang Cuimei Ma

Braz J Med Biol Res 2019 Feb 14;52(2):e7843. Epub 2019 Feb 14.

Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining, China.

Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Read More

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http://dx.doi.org/10.1590/1414-431X20187843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376319PMC
February 2019

Cirrhotic cardiomyopathy: the liver affects the heart.

Braz J Med Biol Res 2019 Feb 14;52(2):e7809. Epub 2019 Feb 14.

Hospital Municipal Dr. Mario Gatti, Campinas, SP, Brasil.

Cirrhotic cardiomyopathy historically has been confused as alcoholic cardiomyopathy. The key points for diagnosis of cirrhotic cardiomyopathy have been well explained, however this entity was neglected for a long time. Nowadays the diagnosis of this entity has become important because it is a factor that contributes significantly to morbidity-mortality in cirrhotic patients. Read More

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http://dx.doi.org/10.1590/1414-431X20187809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376321PMC
February 2019
1 Read

Effects of exposure to fine particulate matter in elderly hospitalizations due to respiratory diseases in the South of the Brazilian Amazon.

Braz J Med Biol Res 2019 Jan 24;52(2):e8130. Epub 2019 Jan 24.

Departamento de Ingeniería Mecánica, Facultad de Ingeniería, Universidad de Concepción, Concepción, Chile.

Exposure to air pollution is an important cause of hospital admissions due to respiratory diseases. Nevertheless, few studies use pollutant concentration data estimated by mathematical models. A time-series ecological study was developed, using data from hospitalizations due to respiratory diseases in people over 60 years of age, residents of Cuiabá, Brazil, during 2012, obtained from the Brazilian Ministry of Health. Read More

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http://dx.doi.org/10.1590/1414-431X20188130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345358PMC
January 2019

Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study.

Braz J Med Biol Res 2019 Jan 24;52(2):e7773. Epub 2019 Jan 24.

Programa de Pós-Graduação Stricto Sensu em Ciências da Saúde, Faculdade de Medicina do ABC, Santo André, SP, Brasil.

The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in two distinct models of acute inflammation. Read More

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http://dx.doi.org/10.1590/1414-431X20187773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345359PMC
January 2019
8 Reads

The safety and efficacy of tPA intravenous thrombolysis for treating acute ischemic stroke patients with a history of cerebral hemorrhage.

Braz J Med Biol Res 2019 Jan 24;52(2):e7739. Epub 2019 Jan 24.

Department of Neurology, The Second Hospital of Shandong University, Jinan, Shandong, China.

Alteplase (tPA) intravenous thrombolysis is an effective treatment for acute ischemic stroke (AIS) when administered within 4.5 h of initial stroke symptoms. Here, its safety and efficacy were evaluated among AIS patients with a previous history of cerebral hemorrhage. Read More

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http://dx.doi.org/10.1590/1414-431X20187739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345357PMC
January 2019
1 Read

Pros and cons of insulin administration on liver glucose metabolism in strength-trained healthy mice.

Braz J Med Biol Res 2019 Jan 24;52(2):e7637. Epub 2019 Jan 24.

Departamento de Ciências Fisiológicas, Universidade Estadual de Maringá, Maringá, PR, Brasil.

Non-diabetic individuals use hormones like insulin to improve muscle strength and performance. However, as insulin also leads the liver and the adipose tissue to an anabolic state, the purpose of this study was to investigate the effects of insulin on liver metabolism in trained non-diabetic Swiss mice. The mice were divided into four groups: sedentary treated with saline (SS) or insulin (SI) and trained treated with saline (TS) or insulin (TI). Read More

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http://dx.doi.org/10.1590/1414-431X20187637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345355PMC
January 2019

Preliminary data for performance in hue ordering tests during pregnancy.

Braz J Med Biol Res 2019 Jan 24;52(2):e7559. Epub 2019 Jan 24.

Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Amapá, Macapá, AP, Brasil.

The visual system of women changes during pregnancy. Few reports have addressed the effects of pregnancy on color vision. We aimed to compare the color vision of women in the first, second, and third trimesters of pregnancy. Read More

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http://dx.doi.org/10.1590/1414-431X20187559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345356PMC
January 2019
1 Read

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis.

Braz J Med Biol Res 2019 Jan 10;52(2):e8109. Epub 2019 Jan 10.

Department of Orthopedics, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.

Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population. A total of 300 OA patients and 300 controls were recruited and their genotypes for ADAMTS5 gene rs226794 and rs2830585 polymorphisms were determined using a custom-by-design 48-Plex single nucleotide polymorphism Scan™ kit. Read More

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http://dx.doi.org/10.1590/1414-431X20188109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328970PMC
January 2019
2 Reads
1.034 Impact Factor

Effects of dipyrone on the digestive tract.

Braz J Med Biol Res 2019 Jan 10;52(2):e8103. Epub 2019 Jan 10.

Departamento de Clinica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors. Read More

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http://dx.doi.org/10.1590/1414-431X20188103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328969PMC
January 2019
3 Reads

Evaluation of platelet activity by multiple electrode impedance aggregometry in acute coronary syndromes: pilot study in a Brazilian tertiary-care public hospital.

Braz J Med Biol Res 2019 Jan 10;52(2):e8001. Epub 2019 Jan 10.

Instituto Nacional de Cardiologia, Ministério da Saúde, Rio de Janeiro, RJ, Brasil.

There is no definite recommendation for testing platelet aggregation (PA) in acute coronary syndromes (ACS) due to inconclusive evidence on the usefulness of platelet function tests to guide therapy and improve clinical outcomes. The evaluation of PA with multiple electrode impedance platelet aggregometry (MEA) may be useful to manage antiplatelet therapy and possibly influence patient outcome. The primary aim of this study was to measure PA with MEA in Brazilian patients with ACS and evaluate the association between PA and adverse clinical outcomes. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20188001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328968PMC
January 2019
8 Reads

Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice.

Braz J Med Biol Res 2018 Dec 10;52(1):e8150. Epub 2018 Dec 10.

Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Maringá, PR, Brasil.

High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. Read More

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http://dx.doi.org/10.1590/1414-431X20188150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301261PMC
December 2018
4 Reads

Kinetics of acid-base parameters in conventional hemodialysis.

Braz J Med Biol Res 2018 Dec 10;52(1):e7974. Epub 2018 Dec 10.

Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA.

Details about the acid-base changes in hemodialysis are scarce in the literature but are potentially relevant to adequate management of patients. We addressed the acid-base kinetics during hemodialysis and throughout the interdialytic period in a cross-sectional study of adults undergoing conventional hemodialysis. Samples for blood gas analysis were obtained from the arterial limb of the arteriovenous fistula before the first session of the week (HD1), immediately at the end of HD1, and on sequential collections at 15, 30, 45, 60, and 120 min post-HD1. Read More

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http://dx.doi.org/10.1590/1414-431X20187974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301264PMC
December 2018
2 Reads

Voluntary wheel running: patterns and physiological effects in mice.

Braz J Med Biol Res 2018 Dec 10;52(1):e7830. Epub 2018 Dec 10.

Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.

Exercise can prevent and improve the pathophysiology of diseases and promote healthy aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise may lead to the development of new strategies to enhance quality of life and to counteract chronic diseases. Voluntary wheel running is an interesting model to study the effects of exercise in mice. Read More

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http://dx.doi.org/10.1590/1414-431X20187830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301263PMC
December 2018
1 Read

CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis.

Braz J Med Biol Res 2018 Dec 10;52(1):e7784. Epub 2018 Dec 10.

Sabin Medicina Diagnóstica, Brasília, DF, Brasil.

Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycoprotein with many functions, such as acting as a phagocytosis inhibitor of the expressing cell, that is increased in normal hematopoietic stem and progenitor cells mobilized into the blood and several human cancer-initiating cells, such as in acute myeloid leukemia. We compared CD47 expression in hematopoietic stem and progenitor cells of patients with MF and controls and found it to be decreased in progenitors of MF. Read More

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http://dx.doi.org/10.1590/1414-431X20187784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301265PMC
December 2018
10 Reads

Effects of nanoparticles of hydroxy-aluminum phthalocyanine on markers of liver injury and glucose metabolism in diabetic mice.

Braz J Med Biol Res 2018 Dec 3;52(1):e7715. Epub 2018 Dec 3.

Departamento de Ciências Fisiológicas, Universidade Estadual de Maringá, Maringá, PR, Brasil.

Photodynamic therapy, by reducing pain and inflammation and promoting the proliferation of healthy cells, can be used to treat recurrent lesions, such as diabetic foot ulcers. Studies using the photosensitizer phthalocyanine, together with the nanostructured copolymeric matrix of Pluronic® and Carbopol® for the treatment of diabetic foot ulcers and leishmaniosis lesions, are showing promising outcomes. Despite their topical or subcutaneous administration, these molecules are absorbed and their systemic effects are unknown. Read More

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http://dx.doi.org/10.1590/1414-431X20187715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293445PMC
December 2018
3 Reads

Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom.

Braz J Med Biol Res 2018 Dec 3;52(1):e7581. Epub 2018 Dec 3.

Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.

Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic activities were investigated in mice. Read More

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http://dx.doi.org/10.1590/1414-431X20187581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293447PMC
December 2018
4 Reads

Red wine consumption, coronary calcification, and long-term clinical evolution.

Braz J Med Biol Res 2018 Nov 29;51(12):e7703. Epub 2018 Nov 29.

Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Coronary artery calcification (CAC) is associated with atherosclerotic complications. However, elevated CAC may not always imply a worse prognosis. Herein, we report the clinical evolution of long-term red wine (RW) drinkers in relation to CAC. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20187703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282067PMC
November 2018
23 Reads

NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Braz J Med Biol Res 2018 Nov 23;52(1):e7952. Epub 2018 Nov 23.

Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. Read More

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http://dx.doi.org/10.1590/1414-431X20187952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262753PMC
November 2018
4 Reads

YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy.

Braz J Med Biol Res 2018 Nov 23;52(1):e7914. Epub 2018 Nov 23.

Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.

Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac matrix remodeling. Read More

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http://dx.doi.org/10.1590/1414-431X20187914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262745PMC
November 2018
5 Reads

Necroptosis occurs in osteoblasts during tumor necrosis factor-α stimulation and caspase-8 inhibition.

Braz J Med Biol Res 2018 Nov 23;52(1):e7844. Epub 2018 Nov 23.

Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Necroptosis is a regulated cell death mechanism. However, it is unknown whether necroptosis is involved in the death of tumor necrosis factor-α (TNF-α)-treated osteoblasts. Therefore, we conducted the study with TNF-α, Nec-1 (a specific inhibitor of necroptosis), and Z-IETD-FMK (a specific inhibitor of apoptosis) to determine whether necroptosis plays a role in the death of TNF-α-treated osteoblast cell line MC3T3-E1. Read More

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http://dx.doi.org/10.1590/1414-431X20187844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262749PMC
November 2018
1 Read

FGFR1 is an independent prognostic factor and can be regulated by miR-497 in gastric cancer progression.

Braz J Med Biol Res 2018 Nov 23;52(1):e7816. Epub 2018 Nov 23.

Department of Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China.

Fibroblast growth factor receptor 1 (FGFR1) has been reported in gastric cancer to be a prognostic factor. However, miR-497-targeted FGFR1 has not been explored in the carcinogenesis of gastric cancer. The present study intended to revalidate the prognostic significance of FGFR1 in patients with gastric cancer, and the mechanism of miR-497-regulated FGFR1 was investigated in gastric cancer cell proliferation and apoptosis. Read More

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http://dx.doi.org/10.1590/1414-431X20187816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262748PMC
November 2018
2 Reads