Search our Database of Scientific Publications and Authors

I’m looking for a

    6742 results match your criteria Brazilian Journal of Medical and Biological Research [Journal]

    1 OF 135

    The use of biosimilar medicines in oncology - position statement of the Brazilian Society of Clinical Oncology (SBOC).
    Braz J Med Biol Res 2018 Jan 11;51(3):e7214. Epub 2018 Jan 11.
    Departamento de Medicina Interna, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
    A biosimilar is a biologic product that is similar to a reference biopharmaceutical product, the manufacturing process of which hinders the ability to identically replicate the structure of the original product, and therefore, it cannot be described as an absolute equivalent of the original medication. The currently available technology does not allow for an accurate copy of complex molecules, but it does allow the replication of similar molecules with the same activity. As biosimilars are about to be introduced in oncology practice, these must be evaluated through evidence-based medicine. Read More

    Association between syndecan-1 and renal function in adolescents with excess weight: evidence of subclinical kidney disease and endothelial dysfunction.
    Braz J Med Biol Res 2018 Jan 11;51(3):e7174. Epub 2018 Jan 11.
    Programa de Pós-Graduação em Saúde Coletiva, Centro de Ciências da Saúde, Universidade de Fortaleza, Fortaleza, CE, Brasil.
    Excess weight (overweight and obesity) is associated with kidney and cardiovascular disease. The aim of this study was to investigate the association between syndecan-1 and renal function among adolescents with excess weight. A total of 56 students from a public school at Fortaleza, CE, Brazil, were investigated. Read More

    Synthesis and anti-myocarditis activity in a multifunctional lanthanide microporous metal-organic framework with 1D helical chain building units.
    Braz J Med Biol Res 2018 Jan 11;51(3):e7050. Epub 2018 Jan 11.
    Department of Cardiology, Shenzhen University General Hospital, Shenzhen, Guangdong, China.
    A new microporous lanthanide metal-organic framework, {[Yb(BTB)(H2O) (DEF)2}n (1, DEF=N,N-Diethylformamide), with 1D nano-sized channels has been constructed by bridging helical chain secondary building units with 1,3,5-benzenetrisbenzoic acid (H3BTB) ligand. Structural characterization suggests that this complex crystallizes in the hexagonal space group P6122 and possesses 1D triangular channels with coordinated water molecules pointing to the channel center. In addition, anti-myocarditis properties of compound 1 were evaluated in vivo. Read More

    Cardiac protein expression patterns are associated with distinct inborn exercise capacity in non-selectively bred rats.
    Braz J Med Biol Res 2018 Jan 11;51(3):e7033. Epub 2018 Jan 11.
    Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, ES, Brasil.
    In the present study, we successfully demonstrated for the first time the existence of cardiac proteomic differences between non-selectively bred rats with distinct intrinsic exercise capacities. A proteomic approach based on two-dimensional gel electrophoresis coupled to mass spectrometry was used to study the left ventricle (LV) tissue proteome of rats with distinct intrinsic exercise capacity. Low running performance (LRP) and high running performance (HRP) rats were categorized by a treadmill exercise test, according to distance run to exhaustion. Read More

    Simulating the behavior of patients who leave a public hospital emergency department without being seen by a physician: a cellular automaton and agent-based framework.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6961. Epub 2018 Jan 11.
    School of Civil, Environmental and Architectural Engineering, Korea University, Seoul, Republic of Korea.
    The objective of this study was to develop an agent based modeling (ABM) framework to simulate the behavior of patients who leave a public hospital emergency department (ED) without being seen (LWBS). In doing so, the study complements computer modeling and cellular automata (CA) techniques to simulate the behavior of patients in an ED. After verifying and validating the model by comparing it with data from a real case study, the significance of four preventive policies including increasing number of triage nurses, fast-track treatment, increasing the waiting room capacity and reducing treatment time were investigated by utilizing ordinary least squares regression. Read More

    Time collection and storage conditions of lipid profile.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6955. Epub 2018 Jan 11.
    Laboratório Central, Disciplina de Medicina Laboratorial, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
    The stability of samples is crucial for getting reliable concentrations of many analytes, including lipid profile. Thus, the goal of this study was to analyze lipid profile under different storage and temperature conditions. This was a prospective study with 809 patients of both genders. Read More

    Efficacy of removal of cariogenic bacteria and carious dentin by ablation using different modes of Er:YAG lasers.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6872. Epub 2018 Jan 11.
    Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, Zagreb, Croatia.
    The primary objective of this in vitro study was to evaluate the efficiency of removal of cariogenic bacteria and carious dentin by ablation using two lasers: fluorescence-feedback controlled (FFC) Er:YAG laser and different pulses of Er:YAG laser based on variable square pulse technology (VSPt). The secondary objective was to measure the temperature during laser ablation of carious tissue. Seventy-two extracted human molars were used in this study. Read More

    A case of severe glutathione synthetase deficiency with novel GSS mutations.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6853. Epub 2018 Jan 11.
    Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    Glutathione synthetase deficiency (GSSD) is a rare inborn error of glutathione metabolism with autosomal recessive inheritance. The severe form of the disease is characterized by acute metabolic acidosis, usually present in the neonatal period with hemolytic anemia and progressive encephalopathy. A case of a male newborn infant who had severe metabolic acidosis with high anion gap, hemolytic anemia, and hyperbilirubinemia is reported. Read More

    Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6601. Epub 2018 Jan 11.
    Instituto Nacional de Cardiologia, Ministério da Saúde, Rio de Janeiro, Brasil.
    The primary aim of this study was to evaluate penile endothelial microvascular function in patients with primary arterial hypertension and age-matched normotensive subjects using laser speckle contrast imaging (LSCI). Additionally, we analyzed the acute penile microvascular effects induced by oral phosphodiesterase type 5 inhibitor (sildenafil; SIL) administration. Endothelium-dependent microvascular reactivity was evaluated in the penises and forearms of hypertensive patients (aged 58. Read More

    Organic solvent exposure and contrast sensitivity: comparing men and women.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6568. Epub 2018 Jan 11.
    Departamento de Psicologia, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
    The goal of this study was to compare the visual contrast sensitivity (CS) of men and women exposed and not exposed to organic solvents. Forty-six volunteers of both genders aged between 18 and 41 years (mean±SD=27.72±6. Read More

    Analysis of serum microRNA expression in male workers with occupational noise-induced hearing loss.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6426. Epub 2018 Jan 11.
    School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, China.
    Occupational noise-induced hearing loss (ONIHL) is a prevalent occupational disorder that impairs auditory function in workers exposed to prolonged noise. However, serum microRNA expression in ONIHL subjects has not yet been studied. We aimed to compare the serum microRNA expression profiles in male workers of ONIHL subjects and controls. Read More

    Evaluating the current state of the art of Huntington disease research: a scientometric analysis.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6299. Epub 2018 Jan 11.
    Laboratório de Biologia Molecular, Universidade Tecnológica Federal do Paraná, Dois Vizinhos, PR, Brasil.
    Huntington disease (HD) is an incurable neurodegenerative disorder caused by a dominant mutation on the 4th chromosome. We aim to present a scientometric analysis of the extant scientific undertakings devoted to better understanding HD. Therefore, a quantitative study was performed to examine the current state-of-the-art approaches that foster researchers' understandings of the current knowledge, research trends, and research gaps regarding this disorder. Read More

    Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis.
    Braz J Med Biol Res 2018 Jan 11;51(3):e6265. Epub 2018 Jan 11.
    Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China.
    The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Read More

    Characterization of air-liquid interface culture of A549 alveolar epithelial cells.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6950. Epub 2017 Dec 11.
    College of Clinical Medicine, Ningxia Medical University, Yinchuan, Ningxia, China.
    Alveolar epithelia play an essential role in maintaining the integrity and homeostasis of lungs, in which alveolar epithelial type II cells (AECII) are a cell type with stem cell potential for epithelial injury repair and regeneration. However, mechanisms behind the physiological and pathological roles of alveolar epithelia in human lungs remain largely unknown, partially owing to the difficulty of isolation and culture of primary human AECII cells. In the present study, we aimed to characterize alveolar epithelia generated from A549 lung adenocarcinoma cells that were cultured in an air-liquid interface (ALI) state. Read More

    Two novel Mg(II)-based and Zn(II)-based complexes: inhibiting growth of human liver cancer cells.
    Braz J Med Biol Res 2017 Dec 18;51(2):e6929. Epub 2017 Dec 18.
    Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
    Two new Mg(II)-based and Zn(II)-based coordination polymers, {[Mg3(BTB)(DMA)4](DMA)2}n (1, H3BTB=1,3,5-benzenetrisbenzoic acid, DMA=N,N-dimethylacetamide) and {(H2NMe2)2[Zn3(BTB)2(OH)(Im)](DMF)9(MeOH)7}n (2, Im=imidazole, DMF=N,N-dimethylformamide), have been successfully synthesized and structurally characterized under solvothermal conditions. 1 contains a linear [Mg3(COO)6] cluster that connected by the fully deprotonated BTB3- ligands to give a kgd-type 2D bilayer structure; 2 represents a microporous 3D pillar-layered system based on the binuclear Zn units and pillared Im ligands, which shows a (3,5)-connected hms topological net. In addition, in vitro anticancer activities of compounds 1 and 2 on 4 human liver cancer cells (HB611, HHCC, BEL-7405 and SMMC-7721) were determined. Read More

    Comparison of Arndt-endobronchial blocker plus laryngeal mask airway with left-sided double-lumen endobronchial tube in one-lung ventilation in thoracic surgery in the morbidly obese.
    Braz J Med Biol Res 2017 Dec 18;51(2):e6825. Epub 2017 Dec 18.
    Department of Anesthesiology, the Cangzhou Central Hospital, Cangzhou, Hebei, China.
    This study aimed to evaluate the feasibility and performance of Arndt-endobronchial blocker (Arndt) combined with laryngeal mask airway (LMA) compared with left-sided double-lumen endobronchial tube (L-DLT) in morbidly obese patients in one-lung ventilation (OLV). In a prospective, randomized double-blind controlled clinical trial, 80 morbidly obese patients (ASA I-III, aged 20-70) undergoing general anesthesia for elective thoracic surgeries were randomly allocated into groups Arndt (n=40) and L-DLT (n=40). In group Arndt, a LMA™ Proseal was placed followed by an Arndt-endobronchial blocker. Read More

    Therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6812. Epub 2017 Dec 11.
    Shanghai Songjiang Hospital, Nanjing Medical University, Nanjing, China.
    Caspase recruitment domain-containing protein 9 (Card9) is located upstream of the nuclear factor kappa B (NF-κB) and p38 mitogen-activated protein kinase (MAPK) inflammatory pathways. This study investigated the therapeutic effect and potential mechanism of pioglitazone in rats with severe acute pancreatitis (SAP). SAP was induced by a retrograde infusion of 5. Read More

    Expression of E-cadherin, Slug and NCAM and its relationship to tumor invasiveness in patients with acromegaly.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6808. Epub 2017 Dec 11.
    Programa de Pós-Graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brasil.
    Pituitary adenomas account for 10-15% of primary intracranial tumors. Growth hormone (GH)-secreting adenomas account for 13% of all pituitary adenomas and cause acromegaly. These tumors can be aggressive, invade surrounding structures and are highly recurrent. Read More

    Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6793. Epub 2017 Dec 11.
    The Second Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing, China.
    Colon cancer is one of the most common digestive tumors. The present study aimed to explore the functional role, as well as the underlying mechanism of long non-coding RNA LINC00261 in colon cancer. Expression of LINC00261 was analyzed in colon cancer cell lines and human normal cell lines. Read More

    Mechanism of hif-1α mediated hypoxia-induced permeability changes in bladder endothelial cells.
    Braz J Med Biol Res 2017 Dec 18;51(2):e6768. Epub 2017 Dec 18.
    Department of Laboratory Medicine, The Fifth People's Hospital of Chengdu, Chengdu, Sichuan Province, China.
    This study aimed to investigate the mechanism of hypoxia-inducible factor-1 alpha (HIF-1α) mediated hypoxia-induced permeability changes in bladder endothelial cells. Models of in vitro hypoxic cell culture of bladder cancer, bladder cancer cells with low HIF-1α expression and HIF-1α RNA interference (RNAi) expression vector were established. Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to detect the expression of HIF-1α and vascular endothelial growth factor (VEGF) in each group. Read More

    Effectiveness of preoperative decolonization with nasal povidone iodine in Chinese patients undergoing elective orthopedic surgery: a prospective cross-sectional study.
    Braz J Med Biol Res 2017 Dec 18;51(2):e6736. Epub 2017 Dec 18.
    Department of Orthopedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
    Staphylococcus aureus colonization in the nares of patients undergoing elective orthopedic surgery increases the potential risk of surgical site infections. Methicillin-resistant S. aureus (MRSA) has gained recognition as a pathogen that is no longer only just a hospital-acquired pathogen. Read More

    Quality of life and adherence to treatment in early-treated Brazilian phenylketonuria pediatric patients.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6709. Epub 2017 Dec 11.
    Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
    Early dietary treatment of phenylketonuria (PKU), an inborn error of phenylalanine (Phe) metabolism, results in normal cognitive development. Although health-related quality of life (HRQoL) of PKU patients has been reported as unaffected in high-income countries, there are scarce data concerning HRQoL and adherence to treatment of PKU children and adolescents from Brazil. The present study compared HRQoL scores in core dimensions of Brazilian early-treated PKU pediatric patients with those of a reference population, and explored possible relationships between adherence to treatment and HRQoL. Read More

    Production and characterization of a biosurfactant produced by Streptomyces sp. DPUA 1559 isolated from lichens of the Amazon region.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6657. Epub 2017 Dec 11.
    Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife, PE, Brasil.
    Surfactants are amphipathic compounds containing both hydrophilic and hydrophobic groups, capable to lower the surface or interfacial tension. Considering the advantages of the use of biosurfactants produced by microorganisms, the aim of this paper was to develop and characterize a biosurfactant produced by Streptomyces sp. DPUA1559 isolated from lichens of the Amazon region. Read More

    Ginsenoside Rg1 protects human renal tubular epithelial cells from lipopolysaccharide-induced apoptosis and inflammation damage.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6611. Epub 2017 Dec 11.
    Transplantation Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
    Ginsenoside Rg1, one of the most notable active components of Panax ginseng, has been widely reported to exert anti-inflammatory actions. This study aimed to reveal whether ginsenoside Rg1 also exhibits beneficial roles against lipopolysaccharide (LPS)-induced apoptosis and inflammation in human renal tubular epithelial cells, and to evaluate the potential role of the component on tubulointerstitial nephritis treatment. HK-2 cells were treated with various doses of ginsenoside Rg1 (0, 50, 100, 150, and 200 μM) in the absence or presence of 5 μg/mL LPS. Read More

    Endothelin-1 receptor antagonists protect the kidney against the nephrotoxicity induced by cyclosporine-A in normotensive and hypertensive rats.
    Braz J Med Biol Res 2017 Dec 11;51(2):e6373. Epub 2017 Dec 11.
    Disciplina de Nefrologia, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
    Cyclosporin-A (CsA) is an immunosuppressant associated with acute kidney injury and chronic kidney disease. Nephrotoxicity associated with CsA involves the increase in afferent and efferent arteriole resistance, decreased renal blood flow (RBF) and glomerular filtration. The aim of this study was to evaluate the effect of Endothelin-1 (ET-1) receptor blockade with bosentan (BOS) and macitentan (MAC) antagonists on altered renal function induced by CsA in normotensive and hypertensive animals. Read More

    T cell subsets and immunoglobulin G levels are associated with the infection status of systemic lupus erythematosus patients.
    Braz J Med Biol Res 2017 Dec 11;51(2):e4547. Epub 2017 Dec 11.
    Department of Rheumatology, Tianjin Medical University General Hospital, Tianjin, China.
    Systemic lupus erythematosus (SLE) is a chronic, autoimmune disorder that affects nearly all organs and tissues. As knowledge about the mechanism of SLE has increased, some immunosuppressive agents have become routinely used in clinical care, and infections have become one of the direct causes of mortality in SLE patients. To identify the risk factors indicative of infection in SLE patients, a case control study of our hospital's medical records between 2011 and 2013 was performed. Read More

    Ilex paraguariensis extracts extend the lifespan of Drosophila melanogaster fed a high-fat diet.
    Braz J Med Biol Res 2017 Nov 30;51(2):e6784. Epub 2017 Nov 30.
    Programa de Pós-Graduação em Bioquímica, Universidade Federal do Pampa, Uruguaiana, RS, Brasil.
    Studies have suggested that total energy intake and diet composition affect lifespan and ageing. A high-fat diet induces oxidative stress and affects the development of diseases. In contrast, antioxidants are capable of reducing its harmful effects. Read More

    Circulating levels of adiponectin and extent of coronary artery disease in patients undergoing elective coronary angiography.
    Braz J Med Biol Res 2017 Nov 30;51(2):e6738. Epub 2017 Nov 30.
    Disciplina de Cardiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
    Adiponectin (APN), an adipose tissue-released adipokine with demonstrated anti-inflammatory and anti-atherogenic properties, is encoded by a gene whose polymorphisms are associated with presence of coronary artery disease (CAD). Serum APN levels are inversely related with presence and complexity of CAD. Within this context, we sought to compare levels of total APN and its high molecular weight form (HMW APN) according to clinical presentation and extent of CAD in patients undergoing elective cardiac catheterization. Read More

    Modulation of the prostaglandin-endoperoxide synthase 2 gene expression by variant haplotypes: influence of the 3'-untranslated region.
    Braz J Med Biol Res 2017 Nov 30;51(2):e6546. Epub 2017 Nov 30.
    Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
    The inducible inflammatory enzyme cycloxigenase-2 is up-regulated in cancer, and favors tumor progression. Cycloxigenase-2 is encoded by the prostaglandin-endoperoxide synthase 2 (PTGS2) gene, which presents sequence variations in the promoter region (PR) and in the 3'-untranslated region (3'-UTR). Different PR (rs689465, rs689466, rs20417) and 3'-UTR (rs5275) variants were generated by site-directed mutagenesis, and combined in haplotypes to access expression levels using a reporter system (luciferase) in human cells (MCF-7 and HEK293FT). Read More

    Effects of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) release from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone.
    Braz J Med Biol Res 2017 Nov 30;51(2):e6520. Epub 2017 Nov 30.
    Department of Cardiothoracic Surgery, Third Affiliated Hospital of Inner Mongolia Medical University, Baotou, Inner Mongolia, China.
    Multiple growth factors can be administered to mimic the natural process of bone healing in bone tissue engineering. We investigated the effects of sequential release of bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone regeneration. To improve the double emulsion/solvent evaporation technique, VEGF was encapsulated in PELA microcapsules, to which BMP-2 was attached. Read More

    Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats.
    Braz J Med Biol Res 2017 Nov 17;51(1):e6388. Epub 2017 Nov 17.
    Laboratório de Neuropsicofarmacologia, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, SP, Brasil.
    The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactive substances. Read More

    Decellularization of placentas: establishing a protocol.
    Braz J Med Biol Res 2017 Nov 17;51(1):e6382. Epub 2017 Nov 17.
    Setor de Anatomia, Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, SP, Brasil.
    Biological biomaterials for tissue engineering purposes can be produced through tissue and/or organ decellularization. The remaining extracellular matrix (ECM) must be acellular and preserve its proteins and physical features. Placentas are organs of great interest because they are discarded after birth and present large amounts of ECM. Read More

    Safety and efficacy of regional citrate anticoagulation in continuous blood purification treatment of patients with multiple organ dysfunction syndrome.
    Braz J Med Biol Res 2017 Nov 17;51(1):e6378. Epub 2017 Nov 17.
    Intensive Care Units, Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China.
    The aim of this study was to discuss the safety and efficacy of regional citrate anticoagulation (RCA) on continuous blood purification (CBP) during the treatment of multiple organ dysfunction syndrome (MODS). Thirty-five patients with MODS were divided into two groups: the local citrate anticoagulation (RCA) group, and the heparin-free blood purification (hfBP) group. The MODS severity was assessed according to Marshall's MODS score criteria. Read More

    Short-term effects of stored homologous red blood cell transfusion on cardiorespiratory function and inflammation: an experimental study in a hypovolemia model.
    Braz J Med Biol Res 2017 Nov 17;51(1):e6258. Epub 2017 Nov 17.
    Instituto de Ensino e Pesquisa, Hospital Sírio-Libanês, São Paulo, SP, Brasil.
    The pathophysiological mechanisms associated with the effects of red blood cell (RBC) transfusion on cardiopulmonary function and inflammation are unclear. We developed an experimental model of homologous 14-days stored RBC transfusion in hypovolemic swine to evaluate the short-term effects of transfusion on cardiopulmonary system and inflammation. Sixteen healthy male anesthetized swine (68±3. Read More

    Bevacizumab and gefitinib enhanced whole-brain radiation therapy for brain metastases due to non-small-cell lung cancer.
    Braz J Med Biol Res 2017 Nov 17;51(1):e6073. Epub 2017 Nov 17.
    Department of Thoracic Surgery, Qianfoshan Hospital of Shandong Province, Shandong University, Ji'nan, Shandong, China.
    Non-small-cell lung cancer (NSCLC) patients who experience brain metastases are usually associated with poor prognostic outcomes. This retrospective study proposed to assess whether bevacizumab or gefitinib can be used to improve the effectiveness of whole brain radiotherapy (WBRT) in managing patients with brain metastases. A total of 218 NSCLC patients with multiple brain metastases were retrospectively included in this study and were randomly allocated to bevacizumab-gefitinib-WBRT group (n=76), gefitinib-WBRT group (n=77) and WBRT group (n=75). Read More

    Fasting: a major limitation for resistance exercise training effects in rodents.
    Braz J Med Biol Res 2017 Nov 17;51(1):e5427. Epub 2017 Nov 17.
    Escola de Educação Física e Esporte, Universidade de São Paulo, São Paulo, SP, Brasil.
    Protocols that mimic resistance exercise training (RET) in rodents present several limitations, one of them being the electrical stimulus, which is beyond the physiological context observed in humans. Recently, our group developed a conditioning system device that does not use electric shock to stimulate rats, but includes fasting periods before each RET session. The current study was designed to test whether cumulative fasting periods have some influence on skeletal muscle mass and function. Read More

    Synthesis, crystal structure, and anti-breast cancer activity of a novel metal-porphyrinic complex [YK(TCPP)(OH)2·(solvents)x].
    Braz J Med Biol Res 2017 Nov 13;51(1):e6858. Epub 2017 Nov 13.
    Department of Radiotherapy, Huaihe Hospital of Henan University, Kaifeng, Henan, China.
    A novel heterometallic metal-porphyrinic framework (MPFs) built from Y and K ions as nods and meso-tetra(4-carboxyphenyl)porphyrin as linkers has been successfully synthesized and characterized. The single crystal X-ray diffraction indicated that this complex 1 exhibited a bilayered architecture of the porphyrins, which is seldom seen in MPFs. In addition, in vitro anticancer activity of complex 1 on three human breast cancer cells (BT474, SKBr-3 and ZR-75-30) was further determined. Read More

    Vitamin D3 levels and NLRP3 expression in murine models of obese asthma: association with asthma outcomes.
    Braz J Med Biol Res 2017 Nov 13;51(1):e6841. Epub 2017 Nov 13.
    Department of Emergency, the First Affiliated Hospital of Guangxi Medical University, The Guangxi Talent Highland for Emergency and Rescue Medicine, Guangxi Colleges and Universities Key Laboratory of Emergency Medicine Research, Nanning, Guangxi, China.
    Vitamin D (25(OH)D3) is an essential nutrient that plays a role in the immune system. Serum 25(OH)D3 is found to be associated with asthma. However, the role of vitamin D in obese asthma remains unclear. Read More

    Radiotherapy modulates expression of EGFR, ERCC1 and p53 in cervical cancer.
    Braz J Med Biol Res 2017 Nov 13;51(1):e6822. Epub 2017 Nov 13.
    Divisão de Pesquisa Clínica e Desenvolvimento Tecnológico, Instituto Nacional de Câncer, Rio de Janeiro, RJ, Brasil.
    Cervical cancer is a public health problem and the molecular mechanisms underlying radioresistance are still poorly understood. Here, we evaluated the modulation of key molecules involved in cell proliferation, cell cycle and DNA repair in cervical cancer cell lines (CASKI and C33A) and in malignant tissues biopsied from 10 patients before and after radiotherapy. The expression patterns of epidermal growth factor receptor (EGFR), excision repair cross-complementation group 1 (ERCC1) and p53 were evaluated in cancer cell lines by quantitative PCR and western blotting, and in human malignant tissues by immunohistochemistry. Read More

    Agonistic activity of tamoxifen, a selective estrogen-receptor modulator (SERM), on arthritic ovariectomized mice.
    Braz J Med Biol Res 2017 Nov 13;51(1):e6799. Epub 2017 Nov 13.
    Programa de Pós-Graduação em Ciências Fisiológicas, Departamento de Fisiologia, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.
    Arthritis is positively associated with the decline of sex hormones, especially estrogen. Tamoxifen (TMX) is a selective estrogen receptor modulator, possessing agonist or antagonistic activity in different tissues. Thus, the objective of this study was to investigate the effect of TMX on the zymosan-induced arthritis model. Read More

    Interregional correlations of glucose metabolism between the basal ganglia and different cortical areas: an ultra-high resolution PET/MRI fusion study using 18F-FDG.
    Braz J Med Biol Res 2017 Nov 13;51(1):e6724. Epub 2017 Nov 13.
    Department of Electronics and Information Engineering, College of Science and Technology, Korea University, Sejong, South Korea.
    Basal ganglia have complex functional connections with the cerebral cortex and are involved in motor control, executive functions of the forebrain, such as the planning of movement, and cognitive behaviors based on their connections. The aim of this study was to provide detailed functional correlation patterns between the basal ganglia and cerebral cortex by conducting an interregional correlation analysis of the 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) data based on precise structural information. Fifteen participants were scanned with 7-Tesla magnetic resonance imaging (MRI) and high resolution research tomography (HRRT)-PET fusion system using 18F-FDG. Read More

    Predicting pathway cross-talks in ankylosing spondylitis through investigating the interactions among pathways.
    Braz J Med Biol Res 2017 Nov 13;51(1):e6698. Epub 2017 Nov 13.
    Department of Orthopedics, Weihaiwei People's Hospital, Weihai, Shandong, China.
    Given that the pathogenesis of ankylosing spondylitis (AS) remains unclear, the aim of this study was to detect the potentially functional pathway cross-talk in AS to further reveal the pathogenesis of this disease. Using microarray profile of AS and biological pathways as study objects, Monte Carlo cross-validation method was used to identify the significant pathway cross-talks. In the process of Monte Carlo cross-validation, all steps were iterated 50 times. Read More

    Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage.
    Braz J Med Biol Res 2017 Nov 13;51(1):e6536. Epub 2017 Nov 13.
    Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai, China.
    Kidney stone disease is a major cause of chronic renal insufficiency. The role of long non-coding RNAs (lncRNAs) in calcium oxalate-induced kidney damage is unclear. Therefore, we aimed to explore the roles of lncRNAs in glyoxylate-exposed and healthy mouse kidneys using microarray technology and bioinformatics analyses. Read More

    Exosomes promote cetuximab resistance via the PTEN/Akt pathway in colon cancer cells.
    Braz J Med Biol Res 2017 Nov 13;51(1):e6472. Epub 2017 Nov 13.
    Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, China.
    Cetuximab is widely used in patients with metastatic colon cancer expressing wildtype KRAS. However, acquired drug resistance limits its clinical efficacy. Exosomes are nanosized vesicles secreted by various cell types. Read More

    Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6733. Epub 2017 Oct 19.
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
    Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Read More

    Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6533. Epub 2017 Oct 19.
    Laboratório de Neurobiologia Comparada, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
    N-acetylcysteine (NAC) inhibits nociceptive transmission. This effect has been associated partly with its antioxidant properties. However, the effect of NAC on the levels of lipid hydroperoxides (a pro-oxidant marker), content of ascorbic acid (a key antioxidant molecule of nervous tissue) and total antioxidant capacity (TAC) is unknown. Read More

    Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6432. Epub 2017 Oct 19.
    Laboratório de Fisiologia do Exercício, Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
    Brain serotonin and dopamine are neurotransmitters related to fatigue, a feeling that leads to reduced intensity or interruption of physical exercises, thereby regulating performance. The present review aims to present advances on the understanding of fatigue, which has recently been proposed as a defense mechanism instead of a "physiological failure" in the context of prolonged (aerobic) exercises. We also present recent advances on the association between serotonin, dopamine and fatigue. Read More

    Different levels of brain-derived neurotrophic factor and cortisol in healthy heavy smokers.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6424. Epub 2017 Oct 19.
    Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
    Studies suggest that brain-derived neurotrophic factor (BDNF) and the hypothalamic-pituitary-adrenal (HPA) axis modulate dopaminergic activity in response to nicotine and that the concentrations of BDNF and cortisol seem to be dependent on the amount and duration of smoking. Therefore, we investigated BDNF and cortisol levels in smokers ranked by daily cigarette consumption. Twenty-seven adult males (13 non-smokers and 14 smokers) participated in the study. Read More

    Bone mineral density and inflammatory bowel disease severity.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6374. Epub 2017 Oct 19.
    Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador, BA, Brasil.
    Inflammatory bowel disease (IBD) is associated with low bone mineral density (BMD). In this study, the association between disease severity and BMD in patients with IBD was evaluated. Associations between BMD and the Montreal classification, disease activity and drug therapy were also tested. Read More

    Effects of Lippia sidoides essential oil, thymol, p-cymene, myrcene and caryophyllene on rat sciatic nerve excitability.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6351. Epub 2017 Oct 19.
    Laboratório de Eletrofisiologia, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.
    Lippia sidoides Cham is a typical herb species of Northeast Brazil with widespread use in folk medicine. The major constituents of the essential oil of L. sidoides (EOLs) are thymol, p-cymene, myrcene, and caryophyllene. Read More

    1 OF 135