6,869 results match your criteria Brazilian Journal of Medical and Biological Research [Journal]


Amifostine reduces inflammation and protects against 5-fluorouracil-induced oral mucositis and hyposalivation.

Braz J Med Biol Res 2019 Feb 25;52(3):e8251. Epub 2019 Feb 25.

Departamento de Fisiologia e Famacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Brasil.

Oral mucositis (OM) is a common and dose-limiting side effect of cancer treatment, including 5-fluorouracil (5-FU) and radiotherapy. The efficacy of the therapeutic measures to prevent OM is limited and disease prevention is not fully observable. Amifostine is a cytoprotective agent with a described anti-inflammatory potential. Read More

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http://dx.doi.org/10.1590/1414-431X20188251DOI Listing
February 2019
1 Read

Effect of risperidone on proliferation and apoptosis of MC3T3-E1 cells.

Braz J Med Biol Res 2019 Feb 25;52(3):e8098. Epub 2019 Feb 25.

Department of Psychiatry, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.

This aim of this study was to assess the molecular mechanism of osteoporosis in schizophrenia patients with risperidone use. Here, we investigated the effects of risperidone on cellular proliferation and apoptosis of a preosteoblast cell line, MC3T3-E1. Cell viability and apoptotic rate of MC3T3-E1 were detected by cell counting kit-8 and flow cytometry at a serial dose of risperidone and at different time points, respectively. Read More

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http://dx.doi.org/10.1590/1414-431X20188098DOI Listing
February 2019
1 Read

Visual and automatic classification of the cyclic alternating pattern in electroencephalography during sleep.

Braz J Med Biol Res 2019 Feb 25;52(3):e8059. Epub 2019 Feb 25.

LaSEEB - Evolutionary Systems and Biomedical Engineering Laboratory, Institute for Systems and Robotics (ISR-Lisboa), Instituto Superior Técnico (IST), University of Lisbon, Lisbon, Portugal.

Cyclic alternating pattern (CAP) is a neurophysiological pattern that can be visually scored by international criteria. The aim of this study was to verify the feasibility of visual CAP scoring using only one channel of sleep electroencephalogram (EEG) to evaluate the inter-scorer agreement in a variety of recordings, and to compare agreement between visual scoring and automatic scoring systems. Sixteen hours of single-channel European data format recordings from four different sleep laboratories with either C4-A1 or C3-A2 channels and with different sampling frequencies were used in this study. Read More

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http://dx.doi.org/10.1590/1414-431X20188059DOI Listing
February 2019
1 Read

Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression.

Braz J Med Biol Res 2019 Feb 25;52(3):e7994. Epub 2019 Feb 25.

Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China.

Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Read More

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http://dx.doi.org/10.1590/1414-431X20187994DOI Listing
February 2019
1 Read

Protective effect of dexmedetomidine against organ dysfunction in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats.

Braz J Med Biol Res 2019 Feb 25;52(3):e7905. Epub 2019 Feb 25.

Department of Anesthesiology, Shenzhen People's Hospital, Shenzhen Anesthesiology Engineering Center, the Second Clinical Medical College, Jinan University, Shenzhen, China.

Dexmedetomidine (DEX), a selective agonist of α2-adrenergic receptors, has anti-inflammation properties and potential beneficial effects against trauma, shock, or infection. Therefore, this study aimed to investigate whether DEX might protect against multiple-organ dysfunction in a two-hit model of hemorrhage/resuscitation (HS) and subsequent endotoxemia. Eighty Wistar rats were randomized into four groups: NS (normal saline), HS/L (HS plus lipopolysaccharide), HS/L+D (HS/L plus dexmedetomidine), and HS/L+D+Y (HS/L+D plus yohimbine). Read More

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http://dx.doi.org/10.1590/1414-431X20187905DOI Listing
February 2019
1 Read

Observation of the effect of bone marrow mesenchymal stem cell transplantation by different interventions on cirrhotic rats.

Braz J Med Biol Res 2019 Feb 25;52(3):e7879. Epub 2019 Feb 25.

Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China.

Bone marrow mesenchymal stem cells (BMSCs) transplantation has attracted attention for the treatment of liver cirrhosis and end-stage liver diseases. Therefore, in this study, we evaluated the effect of different methods of BMSCs transplantation in the treatment of liver cirrhosis in rats. Seventy-two male Sprague-Dawley rats were divided into 7 groups: 10 were used to extract BMSCs, 10 were used as normal group, and the remaining 52 rats were randomly divided into five groups for testing: control group, BMSCs group, BMSCs+granulocyte colony-stimulating factor (G-CSF) group, and BMSCs+Jisheng Shenqi decoction (JSSQ) group. Read More

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http://dx.doi.org/10.1590/1414-431X20187879DOI Listing
February 2019
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Thyroid disorders in Brazil: the contribution of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Authors:
I M Bensenor

Braz J Med Biol Res 2019 Feb 14;52(2):e8417. Epub 2019 Feb 14.

Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, SP, Brasil.

Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests. Read More

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http://dx.doi.org/10.1590/1414-431X20198417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376318PMC
February 2019
1 Read

Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications.

Braz J Med Biol Res 2019 Feb 14;52(2):e8209. Epub 2019 Feb 14.

Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha, Vila Velha, ES, Brasil.

Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264. Read More

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http://dx.doi.org/10.1590/1414-431X20188209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376324PMC
February 2019

Pre-analytical parameters associated with unsuccessful karyotyping in myeloid neoplasm: a study of 421 samples.

Braz J Med Biol Res 2019 Feb 14;52(2):e8194. Epub 2019 Feb 14.

Hospital Israelita Albert Einstein, São Paulo, SP, Brasil.

Cytogenetics is essential in myeloid neoplasms (MN) and pre-analytical variables are important for karyotyping. We assessed the relationship between pre-analytical variables (time from collection to sample processing, material type, sample cellularity, and diagnosis) and failures of karyotyping. Bone marrow (BM, n=352) and peripheral blood (PB, n=69) samples were analyzed from acute myeloid leukemia (n=113), myelodysplastic syndromes (n=73), myelodysplastic syndromes/myeloproliferative neoplasms (n=17), myeloproliferative neoplasms (n=137), and other with conclusive diagnosis (n=6), and reactive disorders/no conclusive diagnosis (n=75). Read More

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http://dx.doi.org/10.1590/1414-431X20188194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376323PMC
February 2019
1 Read

Serotonin induces or inhibits neuritic regeneration of leech CNS neurons depending on neuronal identity.

Braz J Med Biol Res 2019 Feb 14;52(2):e7988. Epub 2019 Feb 14.

Neuroscience Division, National Rehabilitation Institute "Luis Guillermo Ibarra Ibarra", Col. Arenal de Guadalupe, Delegacion Tlalpan, Mexico City, Mexico.

Recovery of motor function after central nervous system (CNS) injury is dependent on the regeneration capacity of the nervous system, which is a multifactorial process influenced, among other things, by the role of neuromodulators such as serotonin. The neurotransmitter serotonin can promote neuronal regeneration but there are also reports of it causing restriction, so it is important to clarify these divergent findings in order to understand the direct scope and side effects of potential pharmacological treatments. We evaluated the effect of serotonin on the extent of neuritic outgrowth and morphology of three different neuronal types in the leech Haementeria officinalis during their regeneration in vitro: Retzius interneurons (Rz), annulus erector (AE) motoneurons, and anterolateral number 1 (AL1) CNS neurons. Read More

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http://dx.doi.org/10.1590/1414-431X20187988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376320PMC
February 2019

Kaempferol suppresses human gastric cancer SNU-216 cell proliferation, promotes cell autophagy, but has no influence on cell apoptosis.

Authors:
Fan Zhang Cuimei Ma

Braz J Med Biol Res 2019 Feb 14;52(2):e7843. Epub 2019 Feb 14.

Department of Gastroenterology, Affiliated Hospital of Jining Medical University, Jining, China.

Gastric cancer remains a serious threat to human health worldwide. Kaempferol is a plant-derived flavonoid compound with a wide range of pharmacological activities. This study aimed to investigate the effects of kaempferol on gastric cancer SNU-216 cell proliferation, apoptosis, and autophagy, as well as underlying potential mechanisms. Read More

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http://dx.doi.org/10.1590/1414-431X20187843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376319PMC
February 2019

Cirrhotic cardiomyopathy: the liver affects the heart.

Braz J Med Biol Res 2019 Feb 14;52(2):e7809. Epub 2019 Feb 14.

Hospital Municipal Dr. Mario Gatti, Campinas, SP, Brasil.

Cirrhotic cardiomyopathy historically has been confused as alcoholic cardiomyopathy. The key points for diagnosis of cirrhotic cardiomyopathy have been well explained, however this entity was neglected for a long time. Nowadays the diagnosis of this entity has become important because it is a factor that contributes significantly to morbidity-mortality in cirrhotic patients. Read More

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http://dx.doi.org/10.1590/1414-431X20187809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376321PMC
February 2019
1 Read

Effects of exposure to fine particulate matter in elderly hospitalizations due to respiratory diseases in the South of the Brazilian Amazon.

Braz J Med Biol Res 2019 Jan 24;52(2):e8130. Epub 2019 Jan 24.

Departamento de Ingeniería Mecánica, Facultad de Ingeniería, Universidad de Concepción, Concepción, Chile.

Exposure to air pollution is an important cause of hospital admissions due to respiratory diseases. Nevertheless, few studies use pollutant concentration data estimated by mathematical models. A time-series ecological study was developed, using data from hospitalizations due to respiratory diseases in people over 60 years of age, residents of Cuiabá, Brazil, during 2012, obtained from the Brazilian Ministry of Health. Read More

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http://dx.doi.org/10.1590/1414-431X20188130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345358PMC
January 2019

Anti-inflammatory and antinociceptive effects of phonophoresis in animal models: a randomized experimental study.

Braz J Med Biol Res 2019 Jan 24;52(2):e7773. Epub 2019 Jan 24.

Programa de Pós-Graduação Stricto Sensu em Ciências da Saúde, Faculdade de Medicina do ABC, Santo André, SP, Brasil.

The aim of this study was to evaluate the therapeutic effects of ultrasound (US)-mediated phonophoresis alone or in association with diclofenac diethylammonium (DCF) administered topically in animal models of inflammation. A pre-clinical, prospective, and randomized experimental study of quantitative and qualitative nature was carried out. Phonophoresis was performed using a therapeutic ultrasound apparatus in two distinct models of acute inflammation. Read More

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http://dx.doi.org/10.1590/1414-431X20187773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345359PMC
January 2019
7 Reads

The safety and efficacy of tPA intravenous thrombolysis for treating acute ischemic stroke patients with a history of cerebral hemorrhage.

Braz J Med Biol Res 2019 Jan 24;52(2):e7739. Epub 2019 Jan 24.

Department of Neurology, The Second Hospital of Shandong University, Jinan, Shandong, China.

Alteplase (tPA) intravenous thrombolysis is an effective treatment for acute ischemic stroke (AIS) when administered within 4.5 h of initial stroke symptoms. Here, its safety and efficacy were evaluated among AIS patients with a previous history of cerebral hemorrhage. Read More

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http://dx.doi.org/10.1590/1414-431X20187739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345357PMC
January 2019
1 Read

Pros and cons of insulin administration on liver glucose metabolism in strength-trained healthy mice.

Braz J Med Biol Res 2019 Jan 24;52(2):e7637. Epub 2019 Jan 24.

Departamento de Ciências Fisiológicas, Universidade Estadual de Maringá, Maringá, PR, Brasil.

Non-diabetic individuals use hormones like insulin to improve muscle strength and performance. However, as insulin also leads the liver and the adipose tissue to an anabolic state, the purpose of this study was to investigate the effects of insulin on liver metabolism in trained non-diabetic Swiss mice. The mice were divided into four groups: sedentary treated with saline (SS) or insulin (SI) and trained treated with saline (TS) or insulin (TI). Read More

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http://dx.doi.org/10.1590/1414-431X20187637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345355PMC
January 2019

Preliminary data for performance in hue ordering tests during pregnancy.

Braz J Med Biol Res 2019 Jan 24;52(2):e7559. Epub 2019 Jan 24.

Programa de Pós-Graduação em Ciências da Saúde, Universidade Federal do Amapá, Macapá, AP, Brasil.

The visual system of women changes during pregnancy. Few reports have addressed the effects of pregnancy on color vision. We aimed to compare the color vision of women in the first, second, and third trimesters of pregnancy. Read More

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http://dx.doi.org/10.1590/1414-431X20187559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345356PMC
January 2019
1 Read

Genetic variation of aggrecanase-2 (ADAMTS5) in susceptibility to osteoarthritis.

Braz J Med Biol Res 2019 Jan 10;52(2):e8109. Epub 2019 Jan 10.

Department of Orthopedics, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, China.

Aggrecanase-2 (ADAMTS5) gene is responsible for aggrecan degradation that may contribute to cartilage destruction in a mouse osteoarthritis (OA) model. We aimed to investigate the effects of ADAMTS5 gene polymorphisms on OA risk in a Chinese population. A total of 300 OA patients and 300 controls were recruited and their genotypes for ADAMTS5 gene rs226794 and rs2830585 polymorphisms were determined using a custom-by-design 48-Plex single nucleotide polymorphism Scan™ kit. Read More

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http://dx.doi.org/10.1590/1414-431X20188109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328970PMC
January 2019
2 Reads
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Effects of dipyrone on the digestive tract.

Braz J Med Biol Res 2019 Jan 10;52(2):e8103. Epub 2019 Jan 10.

Departamento de Clinica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors. Read More

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http://dx.doi.org/10.1590/1414-431X20188103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328969PMC
January 2019
2 Reads

Evaluation of platelet activity by multiple electrode impedance aggregometry in acute coronary syndromes: pilot study in a Brazilian tertiary-care public hospital.

Braz J Med Biol Res 2019 Jan 10;52(2):e8001. Epub 2019 Jan 10.

Instituto Nacional de Cardiologia, Ministério da Saúde, Rio de Janeiro, RJ, Brasil.

There is no definite recommendation for testing platelet aggregation (PA) in acute coronary syndromes (ACS) due to inconclusive evidence on the usefulness of platelet function tests to guide therapy and improve clinical outcomes. The evaluation of PA with multiple electrode impedance platelet aggregometry (MEA) may be useful to manage antiplatelet therapy and possibly influence patient outcome. The primary aim of this study was to measure PA with MEA in Brazilian patients with ACS and evaluate the association between PA and adverse clinical outcomes. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20188001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328968PMC
January 2019
7 Reads

Adipose tissue is less responsive to food restriction anti-inflammatory effects than liver, muscle, and brain in mice.

Braz J Med Biol Res 2018 Dec 10;52(1):e8150. Epub 2018 Dec 10.

Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Maringá, PR, Brasil.

High caloric intake promotes chronic inflammation, insulin resistance, and chronic diseases such as type-2 diabetes, which may be prevented by food restriction (FR). The effect of FR on expression of pro-inflammatory and anti-inflammatory genes in adipose tissue, liver, muscle, and brain was compared. Male Swiss mice were submitted to FR (FR group) or had free access to food (control group) during 56 days. Read More

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http://dx.doi.org/10.1590/1414-431X20188150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301261PMC
December 2018
4 Reads

Kinetics of acid-base parameters in conventional hemodialysis.

Braz J Med Biol Res 2018 Dec 10;52(1):e7974. Epub 2018 Dec 10.

Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA.

Details about the acid-base changes in hemodialysis are scarce in the literature but are potentially relevant to adequate management of patients. We addressed the acid-base kinetics during hemodialysis and throughout the interdialytic period in a cross-sectional study of adults undergoing conventional hemodialysis. Samples for blood gas analysis were obtained from the arterial limb of the arteriovenous fistula before the first session of the week (HD1), immediately at the end of HD1, and on sequential collections at 15, 30, 45, 60, and 120 min post-HD1. Read More

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http://dx.doi.org/10.1590/1414-431X20187974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301264PMC
December 2018
2 Reads

Voluntary wheel running: patterns and physiological effects in mice.

Braz J Med Biol Res 2018 Dec 10;52(1):e7830. Epub 2018 Dec 10.

Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Campinas, SP, Brasil.

Exercise can prevent and improve the pathophysiology of diseases and promote healthy aging. Thus, understanding the mechanisms that regulate the beneficial effects of exercise may lead to the development of new strategies to enhance quality of life and to counteract chronic diseases. Voluntary wheel running is an interesting model to study the effects of exercise in mice. Read More

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http://dx.doi.org/10.1590/1414-431X20187830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301263PMC
December 2018
1 Read

CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis.

Braz J Med Biol Res 2018 Dec 10;52(1):e7784. Epub 2018 Dec 10.

Sabin Medicina Diagnóstica, Brasília, DF, Brasil.

Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of polyclonal hematopoiesis. CD47 is a surface glycoprotein with many functions, such as acting as a phagocytosis inhibitor of the expressing cell, that is increased in normal hematopoietic stem and progenitor cells mobilized into the blood and several human cancer-initiating cells, such as in acute myeloid leukemia. We compared CD47 expression in hematopoietic stem and progenitor cells of patients with MF and controls and found it to be decreased in progenitors of MF. Read More

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http://dx.doi.org/10.1590/1414-431X20187784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301265PMC
December 2018
8 Reads

Effects of nanoparticles of hydroxy-aluminum phthalocyanine on markers of liver injury and glucose metabolism in diabetic mice.

Braz J Med Biol Res 2018 Dec 3;52(1):e7715. Epub 2018 Dec 3.

Departamento de Ciências Fisiológicas, Universidade Estadual de Maringá, Maringá, PR, Brasil.

Photodynamic therapy, by reducing pain and inflammation and promoting the proliferation of healthy cells, can be used to treat recurrent lesions, such as diabetic foot ulcers. Studies using the photosensitizer phthalocyanine, together with the nanostructured copolymeric matrix of Pluronic® and Carbopol® for the treatment of diabetic foot ulcers and leishmaniosis lesions, are showing promising outcomes. Despite their topical or subcutaneous administration, these molecules are absorbed and their systemic effects are unknown. Read More

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http://dx.doi.org/10.1590/1414-431X20187715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293445PMC
December 2018
3 Reads

Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom.

Braz J Med Biol Res 2018 Dec 3;52(1):e7581. Epub 2018 Dec 3.

Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, CE, Brasil.

Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic activities were investigated in mice. Read More

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http://dx.doi.org/10.1590/1414-431X20187581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293447PMC
December 2018
4 Reads

Red wine consumption, coronary calcification, and long-term clinical evolution.

Braz J Med Biol Res 2018 Nov 29;51(12):e7703. Epub 2018 Nov 29.

Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Coronary artery calcification (CAC) is associated with atherosclerotic complications. However, elevated CAC may not always imply a worse prognosis. Herein, we report the clinical evolution of long-term red wine (RW) drinkers in relation to CAC. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20187703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282067PMC
November 2018
21 Reads

NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Braz J Med Biol Res 2018 Nov 23;52(1):e7952. Epub 2018 Nov 23.

Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. Read More

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http://dx.doi.org/10.1590/1414-431X20187952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262753PMC
November 2018
1 Read

YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy.

Braz J Med Biol Res 2018 Nov 23;52(1):e7914. Epub 2018 Nov 23.

Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.

Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac matrix remodeling. Read More

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http://dx.doi.org/10.1590/1414-431X20187914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262745PMC
November 2018
5 Reads

Necroptosis occurs in osteoblasts during tumor necrosis factor-α stimulation and caspase-8 inhibition.

Braz J Med Biol Res 2018 Nov 23;52(1):e7844. Epub 2018 Nov 23.

Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Necroptosis is a regulated cell death mechanism. However, it is unknown whether necroptosis is involved in the death of tumor necrosis factor-α (TNF-α)-treated osteoblasts. Therefore, we conducted the study with TNF-α, Nec-1 (a specific inhibitor of necroptosis), and Z-IETD-FMK (a specific inhibitor of apoptosis) to determine whether necroptosis plays a role in the death of TNF-α-treated osteoblast cell line MC3T3-E1. Read More

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http://dx.doi.org/10.1590/1414-431X20187844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262749PMC
November 2018
1 Read

FGFR1 is an independent prognostic factor and can be regulated by miR-497 in gastric cancer progression.

Braz J Med Biol Res 2018 Nov 23;52(1):e7816. Epub 2018 Nov 23.

Department of Pathology, Mianyang Central Hospital, Mianyang, Sichuan Province, China.

Fibroblast growth factor receptor 1 (FGFR1) has been reported in gastric cancer to be a prognostic factor. However, miR-497-targeted FGFR1 has not been explored in the carcinogenesis of gastric cancer. The present study intended to revalidate the prognostic significance of FGFR1 in patients with gastric cancer, and the mechanism of miR-497-regulated FGFR1 was investigated in gastric cancer cell proliferation and apoptosis. Read More

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http://dx.doi.org/10.1590/1414-431X20187816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262748PMC
November 2018
1 Read

HtrA1 suppresses the growth of pancreatic cancer cells by modulating Notch-1 expression.

Braz J Med Biol Res 2018 Nov 23;52(1):e7718. Epub 2018 Nov 23.

Department of General Surgery, The Afflicted Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.

Pancreatic cancer is well known to be the most deadly malignancy with the worst survival rate of all cancers. High temperature requirement factor A1 (HtrA1) plays an important role in cancer cell proliferation, migration, apoptosis, and differentiation. This study aimed to explore the function of HtrA1 in pancreatic cancer cell growth and its underlying mechanism. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20187718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262754PMC
November 2018
3 Reads

Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/β-catenin pathway.

Braz J Med Biol Res 2018 Nov 23;52(1):e7567. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, Huashan Hospital North, Fudan University, Shanghai, China.

Cervical cancer is one of the most common cancers among women around the world. However, the underlying mechanism involved in cervical cancer progression is incompletely known. In the present study, we determined the role of glycoprotein nonmetastatic melanoma protein B (GPNMB) in tumorigenesis of cervical cancer. Read More

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http://dx.doi.org/10.1590/1414-431X20187567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262743PMC
November 2018
3 Reads

Analysis of the application values of different combination schemes of liquid-based cytology and high-risk human papilloma virus test in the screening of high-grade cervical lesions.

Authors:
Jian Wang

Braz J Med Biol Res 2018 Nov 23;52(1):e7517. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, Institution Zaozhuang Municipal Hospital, Zaozhuang, Shandong Province, China.

The aim of this study was to explore the value of different combination schemes of liquid-based cytology (LBC) and high-risk human papilloma virus (HPV) test in the screening of high-grade (≥CIN 2) cervical lesions. From 5727 women who had undergone examinations with LBC and high-risk HPV test, 1884 patients with positive results of either or both LBC and HPV test were included in this study and underwent cervical biopsy. Based on the pathological examination results, comparisons of the assessment indicators of all diagnostic tests were made, and the application values of LBC and high-risk HPV test and different combination schemes of the two in the screening of high-grade (≥CIN II) cervical lesions were estimated. Read More

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http://dx.doi.org/10.1590/1414-431X20187517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262752PMC
November 2018
1 Read

Interleukin-12 as a biomarker of the beneficial effects of food restriction in mice receiving high fat diet or high carbohydrate diet.

Braz J Med Biol Res 2018 Nov 14;51(12):e7900. Epub 2018 Nov 14.

Departamento de Farmacologia e Terapêutica, Universidade Estadual de Maringá, Maringá, PR, Brasil.

The impact of food restriction (FR) during 56 days on serum levels of cytokines in mice fed a high-fat diet (HFD) or high-carbohydrate diet (HCD) were evaluated. The amount of food was reduced 50% for HFD-FR and HCD-FR groups compared to mice receiving free access to HFD (HFD group) or HCD (HCD group). We quantified the serum levels of basic fibroblast growth factor, granulocyte-macrophage colony-stimulating factor, inducible protein 10, interferon γ, interleukin 1α (IL-1α), IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, keratinocyte chemoattractant, macrophage inflammatory protein-1α, monocyte chemotactic protein 1, monokine induced by IFN-γ, and tumor necrosis factor α. Read More

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http://dx.doi.org/10.1590/1414-431X20187900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247278PMC
November 2018
1 Read

Hereditary angioedema with C1 inhibitor (C1-INH) deficit: the strength of recognition (51 cases).

Braz J Med Biol Res 2018 Nov 14;51(12):e7813. Epub 2018 Nov 14.

Disciplina de Imunologia Clínica, Faculdade de Medicina do ABC, Santo André, SP, Brasil.

Hereditary angioedema (HAE) is a rare autosomal dominant disease due to C1 esterase inhibitor deficiency (C1-INH). The disease is characterized by subcutaneous and submucosal edema in the absence of urticaria due to the accumulation of bradykinin. This descriptive study aimed to evaluate the clinical characteristics of patients with a confirmed diagnosis of HAE referred to our Outpatient Clinic between December 2009 and November 2017. Read More

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http://dx.doi.org/10.1590/1414-431X20187813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247277PMC
November 2018
22 Reads

Adiponectin is protective against endoplasmic reticulum stress-induced apoptosis of endothelial cells in sepsis.

Braz J Med Biol Res 2018 Nov 14;51(12):e7747. Epub 2018 Nov 14.

Department of Histology and Embryology, Binzhou Medical University, Yan Tai, China.

Endoplasmic reticulum (ER) stress is a critical molecular mechanism involved in the pathogenesis of sepsis. Hence, strategies for alleviating this stress may be essential for preventing cardiovascular injuries under sepsis. Adiponectin is secreted by adipocytes and its levels are decreased in sepsis. Read More

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http://dx.doi.org/10.1590/1414-431X20187747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247242PMC
November 2018
12 Reads
1.034 Impact Factor

Astragalus polysaccharides decrease proliferation, migration, and invasion but increase apoptosis of human osteosarcoma cells by up-regulation of microRNA-133a.

Braz J Med Biol Res 2018 Nov 14;51(12):e7665. Epub 2018 Nov 14.

Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Osteosarcoma (OS) has a high incidence, malignity, and frequency of recurrence and metastasis. In this study, we aimed to explore the potential anti-cancer effects of Astragalus polysaccharides (APS) on human OS MG63 cells as well as underlying mechanisms. Viability of MG63 cells was assessed by CCK-8 assay to determine the adequate concentration of APS. Read More

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http://dx.doi.org/10.1590/1414-431X20187665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247244PMC
November 2018
14 Reads

Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function.

Braz J Med Biol Res 2018 Nov 14;51(12):e7599. Epub 2018 Nov 14.

Department of General Surgery, Qingdao West Coast New Area Central Hospital, Qingdao, Shandong, China.

The tumor suppressive role of oridonin, an active compound extracted from Rabdosia rubescens, has been proven in several gastric cancer (GC) cell lines. The present study aimed to evaluate the effect of oridonin on another GC cell line, SNU-216, and explore the potential mechanisms. The viable cell numbers, cell migration, survival fraction, and cell viability were, respectively, evaluated by trypan blue exclusion assay, wound healing assay, clonogenic assay, and CCK-8 assay. Read More

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http://dx.doi.org/10.1590/1414-431X20187599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247279PMC
November 2018
11 Reads

Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II.

Braz J Med Biol Res 2018 Nov 14;51(12):e7526. Epub 2018 Nov 14.

Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

It has been previously demonstrated that the hemodynamic effect induced by angiotensin II (AII) in the liver was completely abolished by losartan while glucose release was partially affected by losartan. Angiotensin II type 1 (AT1) and adrenergic (∝1- and β-) receptors (AR) belong to the G-proteins superfamily, which signaling promote glycogen breakdown and glucose release. Interactive relationship between AR and AT1-R was shown after blockade of these receptors with specific antagonists. Read More

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http://dx.doi.org/10.1590/1414-431X20187526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247243PMC
November 2018
2 Reads

Familial history of hypertension-induced impairment on heart rate variability was not observed in strength-trained subjects.

Braz J Med Biol Res 2018 Nov 14;51(12):e7310. Epub 2018 Nov 14.

Laboratório de Fisiologia Translacional, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brasil.

Family history of hypertension is an important predictive factor for hypertension and is associated with hemodynamic and autonomic abnormalities. Previous studies reported that strength training might reduce arterial blood pressure (AP), as well as improve heart rate variability (HRV). However, the benefits of strength training in the offspring of hypertensive parents have not been fully evaluated. Read More

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http://dx.doi.org/10.1590/1414-431X20187310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247241PMC
November 2018
7 Reads

The rs878081 polymorphism of AIRE gene increases the risk of rheumatoid arthritis in a Chinese Han population: a case-control study.

Braz J Med Biol Res 2018 Nov 1;51(12):e7944. Epub 2018 Nov 1.

Department of Orthopedics, The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu Province, China.

The autoimmune regulator (AIRE), a transcriptional regulator expressed in medullary thymic epithelial cells, plays an important role in thymocyte education and negative selection. Several citations studying the association between the rs878081 exon polymorphism of the AIRE gene and the risk of rheumatoid arthritis (RA) in different populations have yielded conflicting findings. Thus, this case-control study involving 300 RA cases and 300 controls was aimed to identify whether such association existed in a Chinese Han population from East China. Read More

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http://dx.doi.org/10.1590/1414-431X20187944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233524PMC
November 2018
3 Reads

Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge.

Braz J Med Biol Res 2018 Nov 1;51(12):e7811. Epub 2018 Nov 1.

Department of General Surgery, Tongde Hospital of Zhejiang Province, Zhejiang, China.

Among the novel class of endogenous long non-coding RNAs, circular RNA (circRNA) is known as a key regulator in the development and progression of different cancers. Its function and mechanism in the tumorigenesis of colorectal cancer, however, has not been well studied. This study thus aimed to investigate potential regulation of colorectal cancer by circRNAs and the corresponding regulatory mechanism. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/1414-431X20187811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233523PMC
November 2018
5 Reads

Low-intensity pulsed ultrasound promotes proliferation and migration of HaCaT keratinocytes through the PI3K/AKT and JNK pathways.

Braz J Med Biol Res 2018 Oct 18;51(12):e7862. Epub 2018 Oct 18.

Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

Although the effects of low-intensity pulsed ultrasound (LIPUS) on diverse cell types have been fully studied, the functional role of LIPUS in keratinocytes remains poorly understood. This study aimed to investigate the effects of LIPUS on proliferation and migration of HaCaT cells as well as the regulatory mechanisms associated with signaling pathways. Human HaCaT cells were exposed or not to LIPUS, and cell proliferation and migration were measured by BrdU incorporation assay and Transwell assay, respectively. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20187862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207286PMC
October 2018
12 Reads

MicroRNA-221 promotes cell proliferation, migration, and differentiation by regulation of ZFPM2 in osteoblasts.

Braz J Med Biol Res 2018 Oct 18;51(12):e7574. Epub 2018 Oct 18.

Department of Orthopaedics, Ningbo No. 2 Hospital, Ningbo, China.

Bone fracture is a common medical condition, which may occur due to traumatic injury or disease-related conditions. Evidence suggests that microRNAs (miRNAs) can regulate osteoblast differentiation and function. In this study, we explored the effects and mechanism of miR-221 on the growth and migration of osteoblasts using MC3T3-E1 cells. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20187574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207289PMC
October 2018
12 Reads

Cat ownership is associated with increased asthma prevalence and dog ownership with decreased spirometry values.

Braz J Med Biol Res 2018 Oct 18;51(12):e7558. Epub 2018 Oct 18.

Departamento de Clínica Médica, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

The association between pet ownership and the development of allergic and respiratory diseases has been the aim of several studies, however, the effects of exposure in adults remain uncertain. The aims of the present study were to investigate the prevalence of asthma and lung function status among dog and cat owners. This cross-sectional study was performed at two universities with students and workers who were allocated into 3 groups according to pet ownership in the previous year: cat owners, dog owners, and no pets (control group). Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/1414-431X20187558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207287PMC
October 2018
9 Reads

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension.

Braz J Med Biol Res 2018 Oct 18;51(12):e7437. Epub 2018 Oct 18.

Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.

Pulmonary arterial hypertension (PAH), characterized by localized increased arterial blood pressure in the lungs, is a slow developing long-term disease that can be fatal. PAH is characterized by inflammation, vascular tone imbalance, pathological pulmonary vascular remodeling, and right-sided heart failure. Current treatments for PAH are palliative and development of new therapies is necessary. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/1414-431X20187437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207290PMC
October 2018
7 Reads

Cardiorespiratory and metabolic determinants during moderate and high resistance exercise intensities until exhaustion using dynamic leg press: comparison with critical load.

Braz J Med Biol Res 2018 Oct 11;51(11):e7837. Epub 2018 Oct 11.

Programa de Pós-graduação Interunidades em Bioengenharia, Universidade de São Paulo, São Carlos, SP, Brasil.

The objective of this study was to assess cardiovascular, respiratory, and metabolic responses during a commonly used dynamic leg press resistance exercise until exhaustion (TEx) at different intensities and compare with critical load (CL). This was a prospective, cross-sectional, controlled, and crossover study. Twelve healthy young men (23±2. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1414-431X20187837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190210PMC
October 2018
4 Reads