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    6698 results match your criteria Brazilian Journal of Medical and Biological Research [Journal]

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    Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6733. Epub 2017 Oct 19.
    Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
    Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Read More

    Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6533. Epub 2017 Oct 19.
    Laboratório de Neurobiologia Comparada, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
    N-acetylcysteine (NAC) inhibits nociceptive transmission. This effect has been associated partly with its antioxidant properties. However, the effect of NAC on the levels of lipid hydroperoxides (a pro-oxidant marker), content of ascorbic acid (a key antioxidant molecule of nervous tissue) and total antioxidant capacity (TAC) is unknown. Read More

    Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6432. Epub 2017 Oct 19.
    Laboratório de Fisiologia do Exercício, Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
    Brain serotonin and dopamine are neurotransmitters related to fatigue, a feeling that leads to reduced intensity or interruption of physical exercises, thereby regulating performance. The present review aims to present advances on the understanding of fatigue, which has recently been proposed as a defense mechanism instead of a "physiological failure" in the context of prolonged (aerobic) exercises. We also present recent advances on the association between serotonin, dopamine and fatigue. Read More

    Different levels of brain-derived neurotrophic factor and cortisol in healthy heavy smokers.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6424. Epub 2017 Oct 19.
    Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Sociedade Brasileira de Fisiologia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, MG, Brasil.
    Studies suggest that brain-derived neurotrophic factor (BDNF) and the hypothalamic-pituitary-adrenal (HPA) axis modulate dopaminergic activity in response to nicotine and that the concentrations of BDNF and cortisol seem to be dependent on the amount and duration of smoking. Therefore, we investigated BDNF and cortisol levels in smokers ranked by daily cigarette consumption. Twenty-seven adult males (13 non-smokers and 14 smokers) participated in the study. Read More

    Bone mineral density and inflammatory bowel disease severity.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6374. Epub 2017 Oct 19.
    Programa de Pós-Graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador, BA, Brasil.
    Inflammatory bowel disease (IBD) is associated with low bone mineral density (BMD). In this study, the association between disease severity and BMD in patients with IBD was evaluated. Associations between BMD and the Montreal classification, disease activity and drug therapy were also tested. Read More

    Effects of Lippia sidoides essential oil, thymol, p-cymene, myrcene and caryophyllene on rat sciatic nerve excitability.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6351. Epub 2017 Oct 19.
    Laboratório de Eletrofisiologia, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.
    Lippia sidoides Cham is a typical herb species of Northeast Brazil with widespread use in folk medicine. The major constituents of the essential oil of L. sidoides (EOLs) are thymol, p-cymene, myrcene, and caryophyllene. Read More

    Monoterpenoids (thymol, carvacrol and S-(+)-linalool) with anesthetic activity in silver catfish (Rhamdia quelen): evaluation of acetylcholinesterase and GABAergic activity.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6346. Epub 2017 Oct 19.
    Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brasil.
    This study evaluated the anesthetic potential of thymol and carvacrol, and their influence on acetylcholinesterase (AChE) activity in the muscle and brain of silver catfish (Rhamdia quelen). The AChE activity of S-(+)-linalool was also evaluated. We subsequently assessed the effects of thymol and S-(+)-linalool on the GABAergic system. Read More

    Effects of a 4-week high-intensity interval training on pacing during 5-km running trial.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6335. Epub 2017 Oct 19.
    Grupo de Estudos do Desempenho Aeróbio (GEADE-USP), Departamento de Esportes Escola de Educação Física e Esportes, Universidade de São Paulo, São Paulo, Brasil.
    This study analyzed the influence of a 4-week high-intensity interval training on the pacing strategy adopted by runners during a 5-km running trial. Sixteen male recreational long-distance runners were randomly assigned to a control group (CON, n=8) or a high-intensity interval training group (HIIT, n=8). The HIIT group performed high-intensity interval-training twice per week, while the CON group maintained their regular training program. Read More

    MicroRNA profiling identifies miR-7-5p and miR-26b-5p as differentially expressed in hypertensive patients with left ventricular hypertrophy.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6211. Epub 2017 Oct 19.
    Departmento de Ciências Naturais, Universidade Estadual do Sudoeste da Bahia, Vitória da Conquista, BA, Brasil.
    Recent evidence suggests that cell-derived circulating miRNAs may serve as biomarkers of cardiovascular diseases. However, a few studies have investigated the potential of circulating miRNAs as biomarkers for left ventricular hypertrophy (LVH). In this study, we aimed to characterize the miRNA profiles that could distinguish hypertensive patients with LHV, hypertensive patients without LVH and control subjects, and identify potential miRNAs as biomarkers of LVH. Read More

    Effect of a rosmarinic acid supplemented hemodialysis fluid on inflammation of human vascular endothelial cells.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6145. Epub 2017 Oct 19.
    Department of Biomedical Engineering, Chung Yuan Christian University, Chungli, Taiwan.
    Chronic systemic inflammation and repetitive damage of vascular endothelia by incompatible dialysis system are probable causes of cardiovascular disease in patients on dialysis. The present study aimed to assess in vitro biocompatibility and anti-inflammatory effect of hemodialysis fluid supplemented with rosmarinic acid (RA) using human umbilical vein endothelial cells (HUVEC). HUVECs (5×106 cells/mL) were pre-exposed to 1 μg/mL of lipopolysaccharides (LPS) and incubated with RA-supplemented hemodialysis fluid (HDF). Read More

    Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow.
    Braz J Med Biol Res 2017 Oct 19;50(12):e6087. Epub 2017 Oct 19.
    Department of Hematology, The First Central Hospital, Tianjin, China.
    Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Read More

    Total phenolic, flavonoid, alkaloid and iridoid content and preventive effect of Lider-7-tang on lipopolysaccharide-induced acute lung injury in rats.
    Braz J Med Biol Res 2017 Oct 19;50(12):e5916. Epub 2017 Oct 19.
    School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
    Lider-7-tang, a medicine used for the treatment of respiratory diseases especially pneumonia and fever in Mongolian Traditional Medicine, was selected for this phytochemical and pharmacological study. The objectives of the study were to determine total biological active substances and analyze the effects of Lider-7-tang treatment in rats with acute lung injury (ALI). Quantitative determination of the total active constituents (phenolic, flavonoid, iridoid and alkaloid) of the methanol extract of Lider-7-tang was performed using Folin-Ciocalteu reagent, aluminum chloride reagent, Trim-Hill reagent, and Bromocresol green reagent, respectively. Read More

    A practical approach to assess leg muscle oxygenation during ramp-incremental cycle ergometry in heart failure.
    Braz J Med Biol Res 2017 Oct 2;50(12):e6327. Epub 2017 Oct 2.
    Laboratory of Clinical Exercise Physiology, Division of Respiratory and Critical Care Medicine, Queen's University, Kingston, ON, Canada.
    Heart failure is characterized by the inability of the cardiovascular system to maintain oxygen (O2) delivery (i.e., muscle blood flow in non-hypoxemic patients) to meet O2 demands. Read More

    Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms.
    Braz J Med Biol Res 2017 Oct 2;50(12):e6138. Epub 2017 Oct 2.
    Department of Aesthetic, Plastic, and Burn Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.
    The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hemangioma cells, and determined the effects of HIF-1α on the hemangioma cells proliferation, apoptosis, migration and tube formation. Read More

    Effects of vacuum sealing drainage on the treatment of cranial bone-exposed wounds in rabbits.
    Braz J Med Biol Res 2017 Oct 2;50(12):e5837. Epub 2017 Oct 2.
    Department of Burn and Plastic Surgery, the 253rd Hospital of People's Liberation Army, Xincheng District, Hohhot, Inner Mongolia, China.
    This study was designed to assess the efficacy of vacuum sealing drainage (VSD) on skull exposure wounds in rabbits and to investigate the underlying mechanism of the process. Full-thickness excisional circular wounds 2×2 cm with or without periosteum involvement were created in 88 New Zealand white rabbits (mean body weight: 3.0±0. Read More

    Candesartan, rather than losartan, improves motor dysfunction in thioacetamide-induced chronic liver failure in rats.
    Braz J Med Biol Res 2017 Sep 21;50(11):e6665. Epub 2017 Sep 21.
    Department of Microbiology, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia.
    Minimal hepatic encephalopathy is more common than the acute syndrome. Losartan, the first angiotensin-II receptor blocker (ARB), and candesartan, another widely-used ARB, have protected against developing fibrogenesis, but there is no clear data about their curative antifibrotic effects. The current study was designed to examine their effects in an already-established model of hepatic fibrosis and also their effects on the associated motor dysfunction. Read More

    Metabolomics as a promising tool for early osteoarthritis diagnosis.
    Braz J Med Biol Res 2017 Sep 21;50(11):e6485. Epub 2017 Sep 21.
    Divisão de Pesquisa, Instituto Nacional de Traumatologia e Ortopedia Jamil Haddad, Rio de Janeiro, RJ, Brasil.
    Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its pathogenesis. However, no biomarker has been identified to detect this disease at early stages or to track its development. Read More

    Collaborative care model improves self-care ability, quality of life and cardiac function of patients with chronic heart failure.
    Braz J Med Biol Res 2017 Sep 21;50(11):e6355. Epub 2017 Sep 21.
    Department of Nursing, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China.
    Chronic heart failure (CHF) is a common chronic disease that requires much care. This study aimed to explore the effects of collaborative care model (CCM) on patients with CHF. A total of 114 CHF patients were enrolled in this study, and were randomly and equally divided into two groups: control and experimental. Read More

    Absorption mechanism of three curcumin constituents through in situ intestinal perfusion method.
    Braz J Med Biol Res 2017 Sep 21;50(11):e6353. Epub 2017 Sep 21.
    Department of Pharmacy College, Southwest University, Chongqing, China.
    This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism. Read More

    Effects of herbal medicine Sijunzi decoction on rabbits after relieving intestinal obstruction.
    Braz J Med Biol Res 2017 Sep 21;50(11):e6331. Epub 2017 Sep 21.
    Department of Gastrointestinal Surgery, Tianjin Nankai Hospital, Tianjin, China.
    Intestinal obstruction leads to blockage of the movement of intestinal contents. After relieving the obstruction, patients might still suffer with compromised immune function and nutritional deficiency. This study aimed to evaluate the effects of Sijunzi decoction on restoring the immune function and nutritional status after relieving the obstruction. Read More

    The regulatory role of IL-6R in hepatitis B-associated fibrosis and cirrhosis.
    Braz J Med Biol Res 2017 Sep 21;50(11):e6246. Epub 2017 Sep 21.
    Department of Infectious Diseases, Linyi People's Hospital, Linyi, Shandong, China.
    This study investigated the expression and regulation of IL-6R in hepatitis B-associated moderate hepatic fibrosis and cirrhosis. Liver tissues, peripheral blood monocytes (PBMs) and serum were collected from 26 hepatitis B patients with liver fibrosis and 35 hepatitis B patients with liver cirrhosis. The levels of Il-6r mRNA expression in these samples were examined by quantitative real-time PCR and IL-6R protein levels were analyzed by western blot and ELISA. Read More

    Relationship between aerobic capacity and pelvic floor muscles function: a cross-sectional study.
    Braz J Med Biol Res 2017 Sep 21;50(11):e5996. Epub 2017 Sep 21.
    Laboratório de Pesquisa em Saúde da Mulher, Departamento de Fisioterapia, Universidade Federal de São Carlos, São Carlos, SP, Brasil.
    The objective of this study was to evaluate the relationship between aerobic capacity and pelvic floor muscles (PFM) function in adult women. Women aged 18 or over and without urinary dysfunction or other chronic diseases were eligible to participate. They completed the habitual physical activity (HPA) questionnaire, underwent a PFM functional evaluation by palpation and perineometry, and performed a submaximal (between 75 and 85% of maximum heart rate) cardiopulmonary exercise (CPX) test to determine the ventilatory anaerobic threshold (VAT). Read More

    Association between polymorphisms in the APOB gene and hyperlipidemia in the Chinese Yugur population.
    Braz J Med Biol Res 2017 Sep 12;50(11):e6613. Epub 2017 Sep 12.
    The Institute of Minority Physique and Health, Medical College of Northwest University for Nationalities, Lanzhou, China.
    We investigated the influence of apolipoprotein B gene (APOB) variants on the risk of hyperlipidemia (HL) in 631 middle-aged and elderly members of the Chinese Yugur population (HL, n=336; normolipidemia, n=295). APOB polymorphisms were identified using mass spectrometry, and five single nucleotide polymorphisms (rs1042034, rs2163204, rs512535, rs676210, and rs679899) and serum lipids were further analyzed. rs1042034 and rs676210 were significantly associated with HL (P<0. Read More

    Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface.
    Braz J Med Biol Res 2017 Sep 12;50(11):e6527. Epub 2017 Sep 12.
    Department of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
    Immunological mechanisms have been proposed to underlie the pathogenesis of recurrent spontaneous abortion (RSA). Vitamin D has a potent immunomodulatory effect, which may affect pregnancy outcome. The objective of this study was to investigate 25-hydroxyvitamin D [25(OH) D] concentration and vitamin D receptor (VDR) expression in the decidual tissues of RSA patients. Read More

    Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines.
    Braz J Med Biol Res 2017 Sep 12;50(11):e6455. Epub 2017 Sep 12.
    Department of Clinical Laboratory, Chongqing the Seventh People's Hospital, Chongqing, China.
    Series of novel coumarin derivatives [I (a-d) and II (a-d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation. Read More

    Bradykinin, insulin, and glycemia responses to exercise performed above and below lactate threshold in individuals with type 2 diabetes.
    Braz J Med Biol Res 2017 Sep 12;50(11):e6400. Epub 2017 Sep 12.
    Programa de Pós-graduação Stricto Sensu em Educação Física, Universidade Católica de Brasília, Brasília, DF, Brasil.
    The aim of this study was to analyze the acute responses of bradykinin, insulin, and glycemia to exercise performed above and below lactate threshold (LT) in individuals with type 2 diabetes mellitus (T2D). Eleven participants with a diagnosis of T2D randomly underwent three experimental sessions 72 h apart: 1) 20 min of exercise performed at 120% of LT (120%LT), 2) 20 min of exercise performed at 80% of LT (80%LT), and 3) 20 min of control session. Blood glucose was analyzed before, during, and at 45 min post-exercise. Read More

    Down-regulation of single-stranded DNA-binding protein 1 expression induced by HCMV infection promotes lipid accumulation in cells.
    Braz J Med Biol Res 2017 Sep 12;50(11):e6389. Epub 2017 Sep 12.
    Department of Cardiology, Tianjin Chest Hospital, Tianjin Medical University, Tianjin, China.
    The objective of this study was to observe the infection of human cytomegalovirus (HCMV) to human umbilical vein endothelial cells, and its effect on the expression of single-stranded DNA-binding protein (SSBP1) and on lipid metabolism in endothelial cells. We screened the differential expression of mRNAs after HCMV infection by suppression subtractive hybridization and the expression levels of SSBP1 mRNA and protein after HCMV infection by real-time PCR and western blot. After verification of successful infection by indirect immunofluorescent staining and RT-PCR, we found a differential expression of lipid metabolism-related genes including LDLR, SCARB, CETP, HMGCR, ApoB and LPL induced by HCMV infection. Read More

    Tyrosine phosphorylation of Kv1.5 is upregulated in intrauterine growth retardation rats with exaggerated pulmonary hypertension.
    Braz J Med Biol Res 2017 Sep 12;50(11):e6237. Epub 2017 Sep 12.
    Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
    Intrauterine growth retardation (IUGR) is associated with the development of adult-onset diseases, including pulmonary hypertension. However, the underlying mechanism of the early nutritional insult that results in pulmonary vascular dysfunction later in life is not fully understood. Here, we investigated the role of tyrosine phosphorylation of voltage-gated potassium channel 1. Read More

    Molecular analysis of CIB4 gene and protein in Kermani sheep.
    Braz J Med Biol Res 2017 Sep 12;50(11):e6177. Epub 2017 Sep 12.
    Animal Science Department, Shahid Bahonar University of Kerman, Kerman, Iran.
    The human calcium- and integrin-binding protein (CIB) family is composed of CIB1, CIB2, CIB3, and CIB4 proteins and the CIB4 gene affects fertility. Kermani sheep is one of the most important breeds of Iranian sheep breeds. The aim of this study was to analyze for the first time molecular characteristics of the CIB4 gene and protein in Kermani sheep. Read More

    Xuezhikang reduced arterial stiffness in patients with essential hypertension: a preliminary study.
    Braz J Med Biol Res 2017 Aug 31;50(10):e6363. Epub 2017 Aug 31.
    Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing, China.
    This study aimed to test the effects of xuezhikang, a cholestin extract that contains statin-like components, on arterial stiffness in patients with essential hypertension. One hundred hypertensive patients from the Chinese PLA General Hospital were randomly allocated to receive xuezhikang (1200 mg/day, orally) or placebo (same capsules containing only pharmaceutical excipients). Physical examination outcomes, lipid profile, high sensitivity C-reactive protein (hs-CRP) levels, matrix metalloproteinases-9 (MMP-9) levels, and arterial outcomes, including stiffness parameter (β), pressure-strain elasticity modulus (Ep), arterial compliance (AC), augmentation index (AI), and one-point pulse wave velocity (PWVβ) were obtained at baseline and after 6 months of the intervention. Read More

    Evaluation of the toxicity and hypoglycemic effect of the aqueous extracts of Cnidoscolus quercifolius Pohl.
    Braz J Med Biol Res 2017 Aug 31;50(10):e6361. Epub 2017 Aug 31.
    Laboratório de Biotecnologia e Biologia Molecular, Universidade Estadual do Ceará, Fortaleza, CE, Brasil.
    Diabetes mellitus is one of the most common chronic degenerative diseases, and it is estimated to increase worldwide to around 415 million and to impact 642 million in 2040. Research shows that some plants are sources of bioactive compounds against diabetes. Thus, the objective of this work was to evaluate the oral toxicity and the hypoglycemic effect of the aqueous extract of the leaves of Cnidoscolus quercifolius Pohl. Read More

    Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis.
    Braz J Med Biol Res 2017 Aug 31;50(10):e6148. Epub 2017 Aug 31.
    Department of Pediatrics, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. Read More

    Silencing of augmenter of liver regeneration inhibited cell proliferation and triggered apoptosis in U266 human multiple myeloma cells.
    Braz J Med Biol Res 2017 Aug 31;50(10):e6139. Epub 2017 Aug 31.
    Department of Hematology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
    Augmenter of liver regeneration (ALR) is a thermostable cytokine that was originally identified to promote the growth of hepatocytes. This study was conducted to explore the expression and function of ALR in multiple myeloma (MM), a common hematologic malignancy. Real-time PCR and western blot analysis were performed to detect the expression of ALR in U266 human MM cells and healthy peripheral blood mononuclear cells (PBMCs). Read More

    Dipyrone in association with atropine inhibits the effect on gastric emptying induced by hypoglycemia in rats.
    Braz J Med Biol Res 2017 Aug 31;50(10):e5948. Epub 2017 Aug 31.
    Departamento de Bioquímica e Biologia Tecidual, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, SP, Brasil.
    Atropine (AT) and dipyrone (Dp) induce a delay of gastric emptying (GE) of liquids in rats by inhibiting muscarinic receptors and activating β2-adrenergic receptors, respectively. The objective of the present study was to determine the effects of pretreatment with AT and Dp, given alone or in combination, on the effect of hypoglycemia in the liquid GE in rats. Male Wistar adult rats (280-310 g) were pretreated intravenously with AT, Dp, AT plus Dp or their vehicle and then treated 30 min later with iv insulin or its vehicle (n=8-10 animals/group). Read More

    Application of data mining techniques to explore predictors of upper urinary tract damage in patients with neurogenic bladder.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6638. Epub 2017 Aug 17.
    Shenzhen Hospital, Southern Medical University, Shenzhen, China.
    This study proposed a decision tree model to screen upper urinary tract damage (UUTD) for patients with neurogenic bladder (NGB). Thirty-four NGB patients with UUTD were recruited in the case group, while 78 without UUTD were included in the control group. A decision tree method, classification and regression tree (CART), was then applied to develop the model in which UUTD was used as a dependent variable and history of urinary tract infections, bladder management, conservative treatment, and urodynamic findings were used as independent variables. Read More

    Antiviral activity of shikonin ester derivative PMM-034 against enterovirus 71 in vitro.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6586. Epub 2017 Aug 17.
    State Key Laboratory of Pharmaceutical Biotechnology, NJU-NJFU Joint Institute of Plant Molecular Biology, Nanjing University, Nanjing, China.
    Human enterovirus 71 (EV71) is the major causative agent of hand, foot, and mouth disease (HFMD), particularly in infants and children below 4 years of age. Shikonin is a bioactive compound with anti-inflammatory, antiviral, and antibacterial activities derived from the roots of the Chinese medicinal herb Lithospermum erythrorhizon. This study aimed to examine the antiviral activity of PMM-034, a shikonin ester derivative, against EV71 in rhabdomyosarcoma (RD) cells. Read More

    Potential benefit of (-)-epigallocatechin-3-gallate for macrovascular complications in diabetes.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6511. Epub 2017 Aug 17.
    Department of Cardiology, Daping Hospital, Third Military Medical University, Chongqing, China.
    Vascular problems are the most common complications in diabetes. Substantial evidence from epidemiological and pathophysiological studies show that hyperglycemia is a major risk factor for macrovascular complications in patients with diabetes. (-)-Epigallocatechin-3-gallate (EGCG), the major catechin derived from green tea, is known to exert a variety of cardiovascular beneficial effects. Read More

    Is endobronchial ultrasound-guided transbronchial needle aspiration with a stylet necessary for lymph node screening in lung cancer patients?
    Braz J Med Biol Res 2017 Aug 17;50(10):e6372. Epub 2017 Aug 17.
    Department of Respiratory Medicine, Tai Zhou Hospital of Zhejiang Province, LinHai, Zhejiang Province, China.
    During endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), a needle is commonly used with a stylet, although recently the stylet has been omitted. This prospective study aimed to compare the quality of specimens obtained by EBUS-TBNA performed with and without a stylet. Between November 2013 and November 2014, 131 patients with lung cancer underwent EBUS-TBNA, with a total of 148 mediastinal or hilar lymph nodes sampled both with and without an inner-stylet, yielding 296 cytological specimens. Read More

    Proliferation and osteogenic activity of fibroblasts induced with fibronectin.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6272. Epub 2017 Aug 17.
    Tianjin Hospital, Tianjin, China.
    The aim of this study was to determine the proliferation and osteogenic activity of fibroblasts induced with fibronectin and their possible dose-dependent relationship. The fibroblasts obtained by tissue explants adherent method were induced with fibronectin at different concentrations of 0, 10, 20, 40, 60, and 80 μg/mL for 14 days. The 3H-thymidine and 3H-proline incorporation test was used to evaluate the synthesis of DNA and collagen by fibroblasts, respectively. Read More

    Methotrexate associated to lipid core nanoparticles improves cardiac allograft vasculopathy and the inflammatory profile in a rabbit heart graft model.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6225. Epub 2017 Aug 17.
    Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
    Coronary allograft vasculopathy is an inflammatory-proliferative process that compromises the long-term success of heart transplantation and has no effective treatment. A lipid nanoemulsion (LDE) can carry chemotherapeutic agents in the circulation and concentrates them in the heart graft. The aim of the study was to investigate the effects of methotrexate (MTX) associated to LDE. Read More

    Antidepressant effects of Kai-Xin-San in fluoxetine-resistant depression rats.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6161. Epub 2017 Aug 17.
    Department of Clinical Pharmacology, General Hospital of Chinese People's Liberation Army, Beijing, China.
    This study aimed to investigate the antidepressant effect and the mechanism of action of Kai-Xin-San (KXS) in fluoxetine-resistant depressive (FRD) rats. Two hundred male Wistar rats weighing 200±10 g were exposed to chronic and unpredictable mild stresses (CUMS) for 4 weeks and given fluoxetine treatment simultaneously. The rats that did not show significant improvement in behavioral indexes were chosen as the FRD model rats. Read More

    Salinomycin enhances doxorubicin sensitivity through reversing the epithelial-mesenchymal transition of cholangiocarcinoma cells by regulating ARK5.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6147. Epub 2017 Aug 17.
    Department of General Surgery, Qingdao Clinic Medical College, Nanjing Medical University, Qingdao, China.
    Chemotherapy response rates in patients with cholangiocarcinoma remain low, primarily due to the development of drug resistance. Epithelial-mesenchymal transition (EMT) of cancer cells is widely accepted to be important for metastasis and progression, but it has also been linked to the development of chemoresistance. Salinomycin (an antibiotic) has shown some potential as a chemotherapeutic agent as it selectively kills cancer stem cells, and has been hypothesized to block the EMT process. Read More

    Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population.
    Braz J Med Biol Res 2017 Aug 17;50(10):e6115. Epub 2017 Aug 17.
    Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
    Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between PADI4 -92C/G polymorphism and RA. Eligible studies published before May 2016 were identified in PubMed and Chinese databases. Read More

    Comparative efficacy and safety of contact force-sensing catheter and second-generation cryoballoon ablation for atrial fibrillation: a meta-analysis.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6409. Epub 2017 Aug 7.
    Pacing and Electrophysiological Department, the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
    This meta-analysis compared the efficacy and safety of the contact force (CF)-sensing catheter and second-generation cryoballoon (CB) ablation for treating atrial fibrillation (AF). Six controlled clinical trials comparing ablation for AF using a CF-sensing catheter or second-generation CB were identified from PubMed, EMBASE, Cochrane Library, Wanfang Data, and China National Knowledge Infrastructure. The procedure duration was significantly lower in the CB group compared with that in the CF group [mean difference (MD)=29. Read More

    Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6393. Epub 2017 Aug 7.
    Departamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
    Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF. Eighteen patients performed three exercise sessions: 30 min of moderate-intensity (M30) exercise, 30 min of low-intensity (L30) exercise, and 45 min of low-intensity (L45) exercise. Read More

    Noninvasive intracranial pressure monitoring for HIV-associated cryptococcal meningitis.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6392. Epub 2017 Aug 7.
    Braincare Health Technology, São Carlos, SP, Brasil.
    Mortality and adverse neurologic sequelae from HIV-associated cryptococcal meningitis (HIV-CM) remains high due to raised intracranial pressure (ICP) complications. Cerebrospinal fluid (CSF) high opening pressure occurs in more than 50% of HIV-CM patients. Repeated lumbar puncture with CSF drainage and external lumbar drainage might be required in the management of these patients. Read More

    Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6314. Epub 2017 Aug 7.
    Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, São Luís, MA, Brasil.
    Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA model in Wistar rats was used. Read More

    Association between Toll-like receptor 4 Asp299Gly polymorphism and coronary heart disease susceptibility.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6306. Epub 2017 Aug 7.
    Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
    Published data on the association between Toll-like receptor 4 (TLR4) Asp299Gly polymorphism and coronary heart disease (CHD) susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. English-language studies were identified by searching PubMed and Embase databases (up to November 2016). Read More

    Revealing potential long non-coding RNA biomarkers in lung adenocarcinoma using long non-coding RNA-mediated competitive endogenous RNA network.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6297. Epub 2017 Aug 7.
    Department of Pulmonary Disease, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin Province, China.
    In our study, we aimed to reveal potential long non-coding RNAs (lncRNA) biomarkers in lung adenocarcinoma (LAD) using lncRNA-mediated competing endogenous RNAs (ceRNAs) network (LMCN). Competing lncRNA-mRNA interactions were identified using the hypergeometric test. Co-expression analysis for the competing lncRNA-mRNA interactions was implemented, and relying on the weight value >0. Read More

    Cerebrospinal fluid-contacting nucleus mediates nociception via release of fractalkine.
    Braz J Med Biol Res 2017 Aug 7;50(9):e6275. Epub 2017 Aug 7.
    Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, Jiangsu Province, China.
    Increasing evidence suggests that the cerebrospinal fluid-contacting nucleus (CSF-contacting nucleus) mediates the transduction and regulation of pain signals. However, the precise molecular mechanisms remain unclear. Studies show that release of fractalkine (FKN) from neurons plays a critical role in nerve injury-related pain. Read More

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