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    2048 results match your criteria Brazilian Journal of Infectious Diseases [Journal]

    1 OF 41

    Interferon-gamma release assay performance in northeastern Brazil: influence of the IFNG+874 A>T polymorphism.
    Braz J Infect Dis 2018 May 19. Epub 2018 May 19.
    Universidade Federal da Bahia, Instituto de Ciências da Saúde, Salvador, BA, Brazil; Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA, Brazil; Brazilian Network for Research in Tuberculosis - REDE TB, Brazil. Electronic address:
    Introduction: Latent tuberculosis infection diagnosis based on the release of interferon-gamma in cultures of peripheral blood cells stimulated with Mycobacterium tuberculosis antigens has replaced the tuberculin skin test in many countries with low tuberculosis prevalence. The IFN-γ production can be influenced by genetic polymorphisms, of which the IFNG+874 (rs62559044) locus is the most studied. We investigated the possible influence of the IFNG+874 A/T polymorphism on interferon-gamma test performance. Read More

    Prevalence and risk factors of mild chronic renal failure in HIV-infected patients: influence of female gender and antiretroviral therapy.
    Braz J Infect Dis 2018 May 18. Epub 2018 May 18.
    University of Barcelona, Hospital Clinic - IDIBAPS, Infectious Diseases Service, Barcelona, Spain.
    Background: In people living with HIV, much is known about chronic kidney disease, defined as a glomerular filtration rate under 60mL/min. However, there is scarce data about prevalence and risk factors for milder impairment (60-89mL/min).

    Objective: The present study aims to assess the influence of sex, antiretroviral therapy, and classical risk factors on the occurrence of mild decreased renal function in a large Spanish cohort of HIV-infected patients. Read More

    High vertical HIV transmission rate in the Midwest region of Brazil.
    Braz J Infect Dis 2018 May 9. Epub 2018 May 9.
    Universidade Federal do Mato Grosso do Sul, Faculdade de Medicina, Campo Grande, MS, Brazil.
    Objectives: To estimate vertical HIV transmission rate in a capital city of the Midwest region of Brazil and describe the factors related to transmission.

    Methods: A descriptive epidemiological study based on the analysis of secondary data from the Notifiable Diseases Information System (SINAN). The analysis considered all HIV-infected pregnant women with delivery in Campo Grande-MS in the years 2007-2013 and their HIV-exposed infants. Read More

    Effectiveness and tolerability of direct-acting antivirals for chronic hepatitis C patients in a Southern state of Brazil.
    Braz J Infect Dis 2018 May 9. Epub 2018 May 9.
    Universidade Federal do Paraná, Programa de Pós-Graduação em Ciências Farmacêuticas, Curitiba, PR, Brazil. Electronic address:
    Background: This study aimed to evaluate the clinical effectiveness in terms of sustained virological response (SVR) and tolerability of available second generation direct-acting antivirals (DAAs) in Brazilian patients.

    Methods: This was a retrospective observational study conducted in six centers in Southern Brazil. The sample comprised adult patients who were chronically infected with hepatitis C virus (HCV), regardless of virus genotype, fibrosis stage, or prior treatment. Read More

    Initial evaluation of universal immunization with a single dose against hepatitis A virus in Central Brazil.
    Braz J Infect Dis 2018 Apr 20. Epub 2018 Apr 20.
    Universidade Federal de Mato Grosso, Hospital Universitário Júlio Müller, Cuiabá, MT, Brazil. Electronic address:
    Vaccination against the hepatitis A virus (HAV) administered in two doses has been used effectively in universal child immunization programs in several countries. A single-dose vaccination was adopted in some low-income countries in an attempt to reduce costs without losing effectiveness. In 2014, single-dose universal vaccination was introduced in Brazil for children aged two years. Read More

    Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk.
    Braz J Infect Dis 2018 Apr 20. Epub 2018 Apr 20.
    Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Read More

    The impact of ocular tuberculosis on vision after two months of intensive therapy.
    Braz J Infect Dis 2018 Apr 19. Epub 2018 Apr 19.
    Universidade Federal do Espírito Santo, Núcleo de Doenças Infecciosas, Vitória, ES, Brazil. Electronic address:
    Tuberculosis is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. Read More

    Hepatitis C viral load in HCV-monoinfected and HCV/HIV-1-, HCV/HTLV-1/-2-, and HCV/HIV/HTLV-1/-2-co-infected patients from São Paulo, Brazil.
    Braz J Infect Dis 2018 Mar - Apr;22(2):123-128. Epub 2018 Apr 4.
    Secretaria de Estado da Saúde de São Paulo, Coordenadoria de Controle de Doenças, Instituto Adolfo Lutz, Centro de Imunologia, Laboratório de Pesquisa em HTLV, São Paulo, SP, Brazil. Electronic address:
    Co-infections of hepatitis C virus (HCV) and either human immunodeficiency virus type 1 (HIV-1), human T-cell lymphotropic virus type 1 (HTLV-1) or type 2 (HTLV-2) have been described as having an impact on HCV viremia and subsequent disease progression. HCV load in serum samples from 622 patients (343 males, 279 females; median age 50.8 years) from São Paulo/southeast Brazil was analyzed using the Abbott Real Time HCV assay (Abbott Molecular Inc. Read More

    Biofilm production by clinical isolates of Pseudomonas aeruginosa and structural changes in LasR protein of isolates non biofilm-producing.
    Braz J Infect Dis 2018 Mar - Apr;22(2):129-136. Epub 2018 Mar 28.
    Universidade de Pernambuco (UPE), Instituto de Ciências Biológicas, Programa de Pós-graduação em Biologia Celular e Molecular Aplicada, Recife, PE, Brazil.
    Introduction: Biofilm production is an important mechanism for the survival of Pseudomonas aeruginosa and its relationship with antimicrobial resistance represents a challenge for patient therapeutics. P. aeruginosa is an opportunistic pathogen frequently associated to nosocomial infections, especially in imunocompromised hosts. Read More

    Is Visceral Leishmaniasis the same in HIV-coinfected adults?
    Braz J Infect Dis 2018 Mar - Apr;22(2):92-98. Epub 2018 Mar 27.
    Universidade Federal do Ceará, Departamento de Saúde Comunitária, Fortaleza, CE, Brazil.
    Introduction: Visceral Leishmaniasis is the most severe form of disease caused by the Leishmania donovani complex, with significant morbidity and mortality in developing countries. Worse outcomes occur among HIV-positive individuals coinfected with Leishmania. It is unclear, however, if there are significant differences on presentation between Visceral Leishmaniasis patients with or without HIV coinfection. Read More

    Risk behavior score: a practical approach for assessing risk among men who have sex with men in Brazil.
    Braz J Infect Dis 2018 Mar - Apr;22(2):113-122. Epub 2018 Mar 15.
    Departamento de Medicina Preventiva e Social, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.
    HIV/AIDS epidemic is not well controlled, and multiple sexual behavior factors help explain high rates of HIV infection among men who have sex with men (MSM). This article proposes to exam the use of a potential risk behavior score for HIV infection, based on the type and number of sexual partners, and condom use, and their associated factors in a sample of MSM in Brazil. A cross sectional RDS (Respondent Driven Sampling) study was performed among 3738 MSM aged 18+ years old from ten Brazilian cities. Read More

    Scrotal swelling in a farmworker with paracoccidioidomycosis.
    Braz J Infect Dis 2018 Mar - Apr;22(2):155-156. Epub 2018 Mar 16.
    Departamento de Radiologia. Universidade Federal do Rio de Janeiro, Rua Prof. Rodolfo Paulo Rocco, n° 255 - Cidade Universitária - Ilha do Fundão - CEP: 219.419-13. Rio de Janeiro, RJ Brazil. Electronic address:

    Detection of the mecA gene and identification of Staphylococcus directly from blood culture bottles by multiplex polymerase chain reaction.
    Braz J Infect Dis 2018 Mar - Apr;22(2):99-105. Epub 2018 Mar 13.
    UNESP - Univ Estadual Paulista, Instituto de Biociências de Botucatu, Departamento de Microbiologia e Imunologia, Botucatu, SP, Brazil.
    Introduction: Staphylococcus spp. - both S. aureus, including methicillin-resistant strains (MRSA) and coagulase negative staphylococci (CoNS) - are relevant agents of healthcare-associated infections. Read More

    Prevalence of Guillain-Barré syndrome among Zika virus infected cases: a systematic review and meta-analysis.
    Braz J Infect Dis 2018 Mar - Apr;22(2):137-141. Epub 2018 Mar 12.
    Scientific Institute for Research, Hospitalization and Care (IRCCS), Institute for Maternal and Child Health, Trieste, Italy; University of Trieste, Department of Developmental and Reproductive Sciences, Genetic Unit, Trieste, Italy. Electronic address:
    Zika virus (ZIKV) is an emergent flavivirus transmitted mainly through Aedes spp. mosquitoes that is posing challenge to healthcare services in countries experiencing an outbreak. Usually ZIKV infection is mild, but in some cases it has been reported to progress into neurological diseases such as microcephaly in infants and Guillain-Barré syndrome (GBS) in adults. Read More

    Seronegativity to polio viruses among previously immunized adult candidates to solid organ transplantation.
    Braz J Infect Dis 2018 Mar - Apr;22(2):150-152. Epub 2018 Mar 1.
    Universidade Federal do Rio de Janeiro, Departamento de Medicina Preventiva, Rio de Janeiro, RJ, Brazil.
    In the current effort to eliminate polio from the world, it is important to recognize and vaccinate susceptible groups, especially immunocompromised patients living in countries where attenuated polio vaccine is still used. In this report, we describe the frequency of protective antibodies in a small sample of adult SOT candidates in whom previous vaccination could be ascertained. Patients included in this report were selected among the participants of an ongoing prospective study carried out at the Reference Center for Special Immunobiologicals of the Evandro Chagas National Institute of Infectious Diseases in Rio de Janeiro, Brazil. Read More

    In vitro basal T-cell proliferation among asymptomatic Human T cell Leukemia Virus type 1 patients co-infected with hepatitis C and/or Human Immunodeficiency Virus type 1.
    Braz J Infect Dis 2018 Mar - Apr;22(2):106-112. Epub 2018 Feb 28.
    Universidade de São Paulo, Faculdade de Medicina, Departamento de Dermatologia, Laboratório de Investigação em Dermatologia e Imunodeficiências, São Paulo, SP, Brazil; Instituto de Medicina Tropical de São Paulo, São Paulo, SP, Brazil. Electronic address:
    Background: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of Human T cell Leukemia Virus type 1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and viral burden is poorly understood.

    Objective: To evaluate T-cell proliferation in vitro among patients co-infected with Human T cell Leukemia Virus type 1/Hepatitis C Virus/Human Immunodeficiency Virus type 1. Read More

    Seroprevalence of hepatitis E virus in chronic hepatitis C in Brazil.
    Braz J Infect Dis 2018 Mar - Apr;22(2):85-91. Epub 2018 Feb 27.
    Universidade Federal de São Paulo, Departamento de Medicina, Divisão de Doenças Infecciosas, São Paulo, SP, Brazil.
    Background And Aims: Hepatitis E virus infection in patients with underlying chronic liver disease is associated with liver decompensation and increased lethality. The seroprevalence of hepatitis E virus in patients with chronic hepatitis C in Brazil is unknown. This study aims to estimate the seroprevalence of hepatitis E virus in patients with chronic hepatitis C and to describe associated risk factors. Read More

    Non-polarized cytokine profile of a long-term non-progressor HIV infected patient.
    Braz J Infect Dis 2018 Mar - Apr;22(2):142-145. Epub 2018 Feb 21.
    Universidade Federal do Mato Grosso do Sul, Centro de Ciências Biológicas e da Saúde, Campo Grande, MS, Brazil.
    The HIV-1 initial viral infection may present diverse clinical and laboratory course and lead to rapid, intermediate, or long-term progression. Among the group of non-progressors, the elite controllers are those who control the infection most effectively, in the absence of antiretroviral therapy (ART). In this paper, the TH1, TH2 and TH17 cytokines profiles are described, as well as clinical and laboratory aspects of an HIV-infected patient with undetectable viral load without antiretroviral therapy. Read More

    Onabotulinumtoxin type A improves lower urinary tract symptoms and quality of life in patients with human T cell lymphotropic virus type 1 associated overactive bladder.
    Braz J Infect Dis 2018 Mar - Apr;22(2):79-84. Epub 2018 Feb 17.
    Universidade Federal da Bahia (UFBA), Hospital Universitário Prof. Edgard Santos, Serviço de Urologia, Salvador, BA, Brazil; Fiocruz Bahia, Instituto Gonçalo Moniz, Laboratório de Pesquisa Clínica, Salvador, BA, Brazil; Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais (INCT-DT), Salvador, BA, Brazil. Electronic address:
    Aim: To evaluate the efficacy of the onabotulinum toxin type A in the treatment of HTLV-1 associated overactive bladder and its impact on quality of life (QoL).

    Methods: Case series with 10 patients with overactive bladder refractory to conservative treatment with anticholinergic or physical therapy. They received 200Ui of onabotulinumtoxin type A intravesically and were evaluated by overactive bladder symptoms score (OABSS) and King's Health Questionnaire. Read More

    Seroprevalence of human cysticercosis in Jataí, Goiás state, Brazil.
    Braz J Infect Dis 2018 Mar - Apr;22(2):146-149. Epub 2018 Feb 10.
    Universidade Federal de Goiás, Laboratório de Imunologia, Jataí, GO, Brazil. Electronic address:
    The Taenia solium cysticercosis affects millions of people worldwide and is considered a public health problem, especially in developing countries. The diagnosis of neurocysticercosis is complex and involves the analysis of epidemiological, clinical, neuroimaging, and immunological host data. Neurocysticercosis is endemic in Brazil, and is related to the cause of death mainly in the Southeast, South, and Central-West regions. Read More

    Bacteremia due to Moraxella osloensis: a case report and literature review.
    Braz J Infect Dis 2018 Jan - Feb;22(1):60-62. Epub 2018 Feb 2.
    Shinshu University, School of Medicine, Department of Pediatrics, Matsumoto, Japan.
    Herein we report the case of a 10-year-old boy with an autosomal mosaic mutation who developed bacteremia. The causative agent was identified as Moraxella osloensis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene sequencing. In the pediatric population, there have been 13 case reports of infection attributed to M. Read More

    First case of Furuncular Myiasis due to Cordylobia anthropophaga in a Latin American resident returning from Central African Republic.
    Braz J Infect Dis 2018 Jan - Feb;22(1):70-73. Epub 2018 Feb 2.
    Gorgas Memorial Institute, City of Panama, Panama. Electronic address:
    Myiasis is a temporary infection of the skin or other organs with fly larvae. The larvae develop into boil-like lesions. Creeping sensations and pain are usually described by patients. Read More

    Retrospective evaluation of the clinical characteristics associated with Corynebacterium species bacteremia.
    Braz J Infect Dis 2018 Jan - Feb;22(1):24-29. Epub 2018 Jan 19.
    Nihon University School of Medicine, Department of Pathology and Mircobiology, Division of Laboratory Medicine, Tokyo, Japan.
    Objectives: Corynebacterium spp. are becoming recognized as pathogens that potentially cause various infections. We aimed to evaluate the clinical characteristics associated with Corynebacterium spp. Read More

    Transmission of dengue virus from deceased donors to solid organ transplant recipients: case report and literature review.
    Braz J Infect Dis 2018 Jan - Feb;22(1):63-69. Epub 2018 Jan 19.
    Fundación Valle del Lili, División de Cirugía de Trasplante, Cali, Colombia.
    Dengue fever is a vector-transmitted viral infection. Non-vectorial forms of transmission can occur through organ transplantation. We reviewed medical records of donors and recipients with suspected dengue in the first post-transplant week. Read More

    Cost-utility of quadrivalent versus trivalent influenza vaccine in Brazil - comparison of outcomes from different static model types.
    Braz J Infect Dis 2018 Jan - Feb;22(1):1-10. Epub 2018 Jan 18.
    CHESS in Health, Bonheiden, Belgium.
    Background: Influenza burden in Brazil is considerable with 4.2-6.4 million cases in 2008 and influenza-like-illness responsible for 16. Read More

    Humoral immune response to measles and varicella vaccination in former very low birth weight preterm infants.
    Braz J Infect Dis 2018 Jan - Feb;22(1):41-46. Epub 2018 Jan 5.
    Universidade Federal de São Paulo, Departamento de Pediatria, São Paulo, SP, Brazil. Electronic address:
    Introduction: Immune response to vaccination in infants born prematurely may be lower than in infants born at full-term. Some clinical factors might be associated with humoral immune response.

    Objectives: The objectives of this study were to compare the immune response to measles and varicella vaccination in infants born prematurely with those born at full-term and to analyze factors associated with measles and varicella antibody levels. Read More

    Zoonotic spillover and emerging viral diseases - time to intensify zoonoses surveillance in Brazil.
    Braz J Infect Dis 2018 Jan - Feb;22(1):76-78. Epub 2018 Jan 3.
    Laboratório de Imunobiologia e Imunogenética, Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil. Electronic address:

    Hybrid capture as a tool for cervical lesions screening in HIV-infected women: insights from a Brazilian cohort.
    Braz J Infect Dis 2018 Jan - Feb;22(1):16-23. Epub 2017 Dec 6.
    Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas (INI) Evandro Chagas, Rio de Janeiro, RJ, Brazil.
    Introduction: Cervical cancer remains an important burden for HIV-infected women in the era of combination antiretroviral therapy. Recommendations for cervical screening in these women diverge and may include high-risk HPV (HRHPV) testing. We aimed to evaluate the clinical usefulness of a single HRHPV testing for cervical screening of HIV-infected women. Read More

    Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis.
    Braz J Infect Dis 2018 Jan - Feb;22(1):51-54. Epub 2017 Nov 26.
    Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, SP, Brazil.
    A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. Read More

    In vitro antifungal susceptibility of clinical and environmental isolates of Aspergillus fumigatus and Aspergillus flavus in Brazil.
    Braz J Infect Dis 2018 Jan - Feb;22(1):30-36. Epub 2017 Nov 22.
    Universidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Farmacêuticas, Santa Maria, RS, Brazil; Universidade Federal de Santa Maria (UFSM), Centro de Ciências da Saúde, Departamento de Microbiologia e Parasitologia, Laboratório de Pesquisas Micológicas, Santa Maria, RS, Brazil.
    The in vitro susceptibility of 105 clinical and environmental strains of Aspergillus fumigatus and Aspergillus flavus to antifungal drugs, such as amphotericin B, azoles, and echinocandins was evaluated by the broth microdilution method proposed by the European Committee on Antimicrobial Susceptibility Testing (EUCAST). Following the EUCAST-proposed breakpoints, 20% and 25% of the clinical and environmental isolates of A. fumigatus, respectively, were found to be resistant to itraconazole (Minimal Inhibitory Concentration, MIC>2. Read More

    Galactomannan use in clinical practice: providing free testing is not the full answer.
    Braz J Infect Dis 2018 Jan - Feb;22(1):37-40. Epub 2017 Nov 22.
    Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address:
    Introduction: Invasive aspergillosis is a condition associated with a high mortality rate mostly due to difficulties in performing an early diagnosis. In recent years, galactomannan detection has markedly improved the diagnosis of invasive aspergillosis, but very little is known on how physicians deal with this test in clinical practice.

    Methods: This cross-sectional study aimed to analyze the indications for the use of serum galactomannan in a large Brazilian hospital, between 2015 and 2016. Read More

    Methicillin-resistant Staphylococcus aureus isolated from an intensive care unit in Minas Gerais, Brazil, over a six-year period.
    Braz J Infect Dis 2018 Jan - Feb;22(1):55-59. Epub 2017 Nov 21.
    Universidade Federal do Rio de Janeiro, Instituto de Microbiologia Paulo de Góes, Rio de Janeiro, RJ, Brazil. Electronic address:
    To characterize methicillin-resistant Staphylococcus aureus isolates from an intensive care unit of a tertiary-care teaching hospital, between 2005 and 2010. A total of 45 isolates were recovered from patients admitted to the intensive care unit in the study period. Resistance rates higher than 80% were found for clindamycin (100%), erythromycin (100%), levofloxacin (100%), azithromycin (97. Read More

    Isolation of bla-producing Enterobacteriaceae in a public hospital in Salvador, Bahia, Brazil.
    Braz J Infect Dis 2018 Jan - Feb;22(1):47-50. Epub 2017 Nov 13.
    Hospital São Rafael, Salvador, BA, Brazil. Electronic address:
    Carbapenemases have great importance in the global epidemiological scenario since infections with carbapenemase-producing bacteria are associated with high mortality, especially in hospitalized patients in intensive care units. This study describes two microorganisms producers of the New Delhi Metallo-b-lactamase, Klebsiella pneumoniae and Citrobacter freundii, from two patients admitted to a public hospital in Salvador, Bahia. These are the first clinical cases of New Delhi Metallo-b-lactamase described in microorganisms in the north and northeast Brazil. Read More

    Fluconazole levels in serum and cerebrospinal fluid according to daily dosage in patients with cryptococcosis and other fungal infections.
    Braz J Infect Dis 2018 Jan - Feb;22(1):11-15. Epub 2017 Nov 13.
    Universidade de São Paulo (USP), Faculdade de Medicina de Ribeirão Preto, Departamento de Clínica Médica, Ribeirão Preto, SP, Brazil.
    Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid. In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AIDS and 13 had neurocryptococcosis. Read More

    Does SOFA predict outcomes better than SIRS in Brazilian ICU patients with suspected infection? A retrospective cohort study.
    Braz J Infect Dis 2017 Nov - Dec;21(6):665-669. Epub 2017 Oct 13.
    Hospital Moinhos de Vento, Departamento de Cuidados Intensivos, Porto Alegre, RS, Brazil.
    We compared the discriminatory capacity of the sequential organ failure assessment (SOFA) versus the systemic inflammatory response syndrome (SIRS) score for predicting ICU mortality, need for and length of mechanical ventilation, ICU stay, and hospitalization in patients with suspected infection admitted to a mixed Brazilian ICU. We performed a retrospective analysis of a longitudinal ICU database from a tertiary hospital in Southern Brazil. Patients were categorized according to whether they met the criteria for sepsis according to SOFA (variation ≥2 points over the baseline clinical condition) and SIRS (SIRS score ≥2 points). Read More

    Humoral and cellular immune response of mice challenged with Yersinia pestis antigenic preparations.
    Braz J Infect Dis 2017 Nov - Dec;21(6):620-626. Epub 2017 Oct 12.
    Universidade Federal de Minas Gerais, Faculdade de Farmácia, Departamento de Análises Clínicas e Toxicológicas, Belo Horizonte, MG, Brazil.
    Objectives: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. Read More

    Molecular diagnosis of symptomatic toxoplasmosis: a 9-year retrospective and prospective study in a referral laboratory in São Paulo, Brazil.
    Braz J Infect Dis 2017 Nov - Dec;21(6):638-647. Epub 2017 Sep 29.
    Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto, SP, Brazil; Hospital da Criança e Maternidade, São José do Rio Preto, SP, Brazil.
    Symptomatic forms of toxoplasmosis are a serious public health problem and occur in around 10-20% of the infected people. Aiming to improve the molecular diagnosis of symptomatic toxoplasmosis in Brazilian patients, this study evaluated the performance of real time PCR testing two primer sets (B1 and REP-529) in detecting Toxoplasma gondii DNA. The methodology was assayed in 807 clinical samples with known clinical diagnosis, ELISA, and conventional PCR results in a 9-year period. Read More


    Comparison between the gold standard DXA with calcaneal quantitative ultrasound based-strategy (QUS) to detect osteoporosis in an HIV infected cohort.
    Braz J Infect Dis 2017 Nov - Dec;21(6):581-586. Epub 2017 Sep 23.
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy.
    Introduction: Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. Read More

    Ceftolozane-tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Latin America: report from an antimicrobial surveillance program (2013-2015).
    Braz J Infect Dis 2017 Nov - Dec;21(6):627-637. Epub 2017 Sep 21.
    JMI Laboratories, North Liberty, IA, United States.
    This study evaluated the in vitro activity of ceftolozane-tazobactam and comparator agents tested against Latin American isolates of Enterobacteriaceae and Pseudomonas aeruginosa from patients with health care-associated infections. Ceftolozane-tazobactam is an antipseudomonal cephalosporin combined with a well-established β-lactamase inhibitor. A total of 2415 Gram-negative organisms (537 P. Read More

    Mobile health application to assist doctors in antibiotic prescription - an approach for antibiotic stewardship.
    Braz J Infect Dis 2017 Nov - Dec;21(6):660-664. Epub 2017 Sep 21.
    Pontifícia Universidade Católica do Paraná, Escola de Saúde e Biociências, Departamento de Medicina, Curitiba, PR, Brazil.
    Background: Technologies applied to mobile devices can be an important strategy in antibiotic stewardship programs.

    Objective: The aim of this study was to determine the impact of a decision-making application on antibiotic prescription.

    Methods: This was an observational, analytical and longitudinal study on the implementation of an antimicrobial guide for mobile application. Read More

    Subcutaneous infection by Graphium basitruncatum in a heart transplant patient.
    Braz J Infect Dis 2017 Nov - Dec;21(6):670-674. Epub 2017 Sep 18.
    Universidad de Buenos Aires, Facultad de Medicina, Departamento de Microbiología y Parasitología Médica, Buenos Aires, Argentina. Electronic address:
    Graphium basitruncatum, a synanamorph of Pseudoallescheria has been rarely reported in human infections. We report a case of subcutaneous phaeohyphomycosis caused by this fungus in a heart transplant recipient. We also describe the phenotypic, molecular methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) used to achieve isolate identification. Read More

    Clonal dissemination of vancomycin-resistant Enterococcus faecium ST412 in a Brazilian region.
    Braz J Infect Dis 2017 Nov - Dec;21(6):656-659. Epub 2017 Jul 29.
    Universidade Federal de Espírito Santo, Centro de Ciências da Saúde, Departamento de Patologia, Vitória, ES, Brazil. Electronic address:
    Vancomycin-resistant Enterococcus faecium (VREfm) has emerged as an important global nosocomial pathogen, and this trend is associated with the spread of high-risk clones. Here, we determined the genetic and phenotypic features of 93 VREfm isolates that were obtained from patients in 13 hospitals in Vitória, Espírito Santo, Brazil, during 2012-2013. All the isolates were vancomycin-resistant and harbored the vanA gene. Read More

    Serum markers as an aid in the diagnosis of pulmonary fungal infections in AIDS patients.
    Braz J Infect Dis 2017 Nov - Dec;21(6):606-612. Epub 2017 Jul 29.
    Universidade de Campinas, Faculdade de Ciências Médicas, Departamento de Medicina Interna, Campinas, SP, Brazil. Electronic address:
    Introduction: The etiology of pulmonary infections in HIV patients is determined by several variables including geographic region and availability of antiretroviral therapy.

    Materials And Methods: A cross-sectional prospective study was conducted from 2012 to 2016 to evaluate the occurrence of pulmonary fungal infection in HIV-patients hospitalized due to pulmonary infections. Patients' serums were tested for (1-3)-β-D-Glugan, galactomannan, and lactate dehydrogenase. Read More

    Comparison of the ACC/AHA and Framingham algorithms to assess cardiovascular risk in HIV-infected patients.
    Braz J Infect Dis 2017 Nov - Dec;21(6):577-580. Epub 2017 Jul 19.
    Escola de Ciências da Santa Casa de Vitória, Unidade de Doenças Infecciosas, Vitória, ES, Brazil.
    The aim of this study was to compare the predictions of Framingham cardiovascular (CV) risk score (FRS) and the American College of Cardiology/American Heart Association (ACC/AHA) risk score in an HIV outpatient clinic in the city of Vitoria, Espirito Santo, Brazil. In a cross-sectional study 341 HIV infected patients over 40 years old consecutively recruited were interviewed. Cohen's kappa coefficient was used to assess agreement between the two algorithms. Read More

    A cross-sectional study assessing the pharyngeal carriage of Neisseria meningitidis in subjects aged 1-24 years in the city of Embu das Artes, São Paulo, Brazil.
    Braz J Infect Dis 2017 Nov - Dec;21(6):587-595. Epub 2017 Jul 14.
    GSK Brazil, Rio de Janeiro, RJ, Brazil.
    Meningococcal carriage is a prerequisite for invasive infection. This cross-sectional study assessed the pharyngeal carriage prevalence in healthy subjects aged 1-24 years in Embu das Artes city, São Paulo, Brazil. Pharyngeal swabs were examined for the presence of Neisseria meningitidis. Read More

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