2,215 results match your criteria Brazilian Journal Of Infectious Diseases[Journal]


Analysis of clinical and demographic heterogeneity of patients dying from COVID-19 in Brazil versus China and Italy.

Braz J Infect Dis 2020 May 29. Epub 2020 May 29.

Cincinnati Children's Hospital Medical Center, The Heart Institute, Cardiac Intensive Care Unit, Ohio, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bjid.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256538PMC

Seroprevalence and factors associated with Human Immunodeficiency virus, Human T lymphotropic virus and Hepatitis B/C infections in parturient women of Salvador - Bahia, Brazil.

Braz J Infect Dis 2020 May 25. Epub 2020 May 25.

Universidade Federal da Bahia, Faculdade de Medicina, Salvador, BA, Brazil; Universidade Federal de Bahia, Complexo Hospitalar Universitário Professor Edgard Santos, Salvador, BA, Brazil.

Background: The heterogeneity in detection rates of Human immunodeficiency virus, (HIV), Human T lymphotropic virus (HTLV) and Hepatitis B and C infections among pregnant women and the continuous exposure to risk factors limits the adoption of preventive and control actions.

Objective: To evaluate the HIV, HTLV, Hepatitis B and C seroprevalence rates, and associated risk factors in parturient women in Salvador, Brazil.

Methods: This was a cross-sectional study in 2099 parturient women attended in two public maternity hospitals in Salvador, Brazil. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.05.001DOI Listing

Cost minimization analysis and validation of a cytomegalovirus quantitative in-house real time PCR assay in relation to m2000 RealTime System.

Braz J Infect Dis 2020 May 23. Epub 2020 May 23.

Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, RS, Brazil; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil. Electronic address:

Introduction: Cytomegalovirus (CMV) causes severe diseases in the immunocompromised patients. Nowadays, quantitative polymerase chain reaction (qPCR) is the gold-standard for diagnosis and monitoring of CMV infection. Most of the studies use CMV automated molecular assays which are expensive and, therefore, not an option for small laboratories, particularly in the developing world. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.015DOI Listing

High prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae in Western French Guiana.

Braz J Infect Dis 2020 May 19. Epub 2020 May 19.

Western French Guiana Hospital Center Franck-Joly, Department of Public Health, Saint-Laurent du Maroni, French Guiana; INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et Santé Publique (IPLESP), Equipe de Recherche en Epidémiologie Sociale (ERES), Paris, France. Electronic address:

The purpose of this study was to estimate the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in western French Guiana and to analyze associated factors with both infections. A retrospective study was conducted in a sexually transmitted infections clinic in 2017. Women (n=338) were tested by real-time polymerase chain reaction for vaginal, anal and throat CT and NG infections. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.014DOI Listing

Nontuberculous mycobacterial infection in a tertiary care center in Mexico, 2001-2017.

Braz J Infect Dis 2020 May 16. Epub 2020 May 16.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Department of Infectious Diseases, Laboratory of Clinical Microbiology, Mexico City, Mexico. Electronic address:

Introduction: Nontuberculous mycobacteria (NTM) comprise several pathogens with a complex profile of virulence, diverse epidemiological and clinical patterns as well as host specificity. Recently, an increase in the number of NTM infections has been observed; therefore, the objective of this study was to evaluate the clinical characteristics and outcomes of these infections.

Methods: We included patients with NTM infections between 2001-2017 and obtained risk factors, clinical features and outcomes; finally, we compared this data between slowly growing (SGM) and rapidly growing mycobacteria (RGM). Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.012DOI Listing

Viral metagenomics performed in patients with acute febrile syndrome during Toxoplasma gondii outbreak in south Brazil.

Braz J Infect Dis 2020 May 15. Epub 2020 May 15.

University of São Paulo, Faculty of Medicine of Ribeirão Preto, Blood Center of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil; University of São Paulo, Faculty of Medicine of Ribeirão Preto, Department of Internal Medicine, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Toxoplasmosis is a zoonotic infection caused by the protozoan parasite Toxoplasma gondii. The infection is widely disseminated in the human population and is usually benign or asymptomatic. Systemic T. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.011DOI Listing

Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil.

Braz J Infect Dis 2020 May 15. Epub 2020 May 15.

Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina Interna, UNIFESP, São Paulo, SP, Brazil.

Due to the emergence of multi-drug resistant bacteria, and the evident limitation in therapeutic options, alternatives to combat bacterial infections have been sought. One of these is phage therapy, which is the use of bacterial viruses to kill pathogenic bacteria responsible for the infection. These viruses called bacteriophages are very abundant organisms in the world and are harmless to humans. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.010DOI Listing

Real-world evidence in antiretroviral therapy: drug safety data.

Braz J Infect Dis 2020 May 15. Epub 2020 May 15.

University of Porto, Faculty of Medicine, Health Information and Decision (MEDCIDS), Porto, Portugal; University of Porto, Faculty of Medicine, Center for Health Technology and Service Research (CINTESIS), Porto, Portugal.

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http://dx.doi.org/10.1016/j.bjid.2020.04.013DOI Listing

The 2019-2020 coronavirus pandemic in Italy: immunologic and cultural hurdles on the road to a cure.

Authors:
Edoardo Virgilio

Braz J Infect Dis 2020 May 6. Epub 2020 May 6.

University "Sapienza", Faculty of Medicine and Psychology, Medical and Surgical Sciences and Translational Medicine, Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bjid.2020.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200331PMC
May 2020
1.096 Impact Factor

An infant with a mild SARS-CoV-2 infection detected only by anal swabs: a case report.

Braz J Infect Dis 2020 May 6. Epub 2020 May 6.

Changxing County Hospital, of Traditional Chinese Medicine, Department of Respiratory Medicine, Huzhou, Zhejiang Province, China. Electronic address:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China and has spread rapidly worldwide. We present a mild SARS-CoV-2 infection in a baby with non-productive cough and normal chest computed tomography, in whom only anal swabs tested positive by real-time PCR testing for SARS-CoV-2. She was given atomization inhalation therapy with recombinant human interferon alfa-1b for 10 days. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200387PMC

Will environmental changes in temperature affect the course of COVID-19?

Braz J Infect Dis 2020 May 4. Epub 2020 May 4.

Hospital Universitario "Dr. José Eleuterio González", Department of Hospital Epidemiology, Monterrey N.L., Mexico. Electronic address:

While the outbreak has reached every region of the world, it is undeniable that countries in the southern hemisphere seem to be less affected, where cases have been reported, these have been imported and travel related. We analyzed the climate temperature from various regions according to their current ongoing human-to-human transmission status. We studied 3 groups; Group 1, 10 provinces from China with majority of COVID-19 cases; Group 2, areas where continuous horizontal transmission outside of China had been reported; and group 3, areas where imported cases had been detected and no horizontal transmission had been documented after at least seven days since the first case was reported. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196892PMC
May 2020
1.096 Impact Factor

Joint report of SBI (Brazilian Society of Infectious Diseases), FEBRASGO (Brazilian Federation of Gynecology and Obstetrics Associations), SBU (Brazilian Society of Urology) and SBPC/ML (Brazilian Society of Clinical Pathology/Laboratory Medicine): recommendations for the clinical management of lower urinary tract infections in pregnant and non-pregnant women.

Braz J Infect Dis 2020 Mar - Apr;24(2):110-119. Epub 2020 Apr 30.

Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Departamento de Medicina, São Paulo, SP, Brazil.

Urinary tract infection (UTI) is a common condition in women. There is an increased concern on reduction of bacterial susceptibility resulting from wrongly prescribing antimicrobials. This paper summarizes the recommendations of four Brazilian medical societies (SBI - Brazilian Society of Infectious Diseases, FEBRASGO - Brazilian Federation of Gynecology and Obstetrics Associations, SBU - Brazilian Society of Urology, and SBPC/ML - Brazilian Society of Clinical Pathology/Laboratory Medicine) on the management of urinary tract infection in women. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.002DOI Listing

Profile of drug-drug interactions and impact on the effectiveness of antiretroviral therapy among patients living with HIV followed at an Infectious Diseases Referral Center in Belo Horizonte, Brazil.

Braz J Infect Dis 2020 Mar - Apr;24(2):104-109. Epub 2020 Apr 29.

Universidade Federal de Minas Gerais (UFMG), Health Sciences: Infectology and Tropical Medicine, Faculdade de Medicina, Belo Horizonte, MG, Brazil; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Medicina Interna, Belo Horizonte, MG, Brazil.

HIV infection may be considered a chronic condition for people living with HIV with access to antiretrovirals and this has effectively increased survival. Moreover, this has also facilitated the emergence of other comorbidities increasing the risk for drug-drug interactions and polypharmacy. The profile of these interactions as well as their consequences for people living with HIV are still not completely elucidated. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.03.006DOI Listing

Evaluation of in vitro activity of ceftolozane-tazobactam against recent clinical bacterial isolates from Brazil - the EM200 study.

Braz J Infect Dis 2020 Mar - Apr;24(2):96-103. Epub 2020 Apr 28.

Merck Sharp Dohme Brazil, São Paulo, SP, Brazil.

Background: The emergence of antibiotic resistance is increasing and there are few effective antibiotics to treat infections caused by resistant and multidrug resistant bacterial pathogens. This study aimed to evaluate the in vitro activity of ceftolozane-tazobactam against clinical bacterial isolates from Brazil.

Methods: A total of 673 Gram-negative bacterial isolates including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and other Enterobacterales collected from 2016 to 2017 were tested, most of them isolated from patients in intensive care units. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.004DOI Listing

Reactivity of sera from dogs living in a leishmaniasis-endemic area to the COOH-terminal region of cysteine proteinase B.

Braz J Infect Dis 2020 Apr 25. Epub 2020 Apr 25.

Fundação Oswaldo Cruz, Instituto Oswaldo Cruz, Laboratório de Biologia Molecular e Doenças Endêmicas, Rio de Janeiro, RJ, Brazil. Electronic address:

Cysteine proteinases are well-known virulence factors of Leishmania spp. with demonstrated actions in both experimental mouse infection and human infection. However, studies on these enzymes in canine leishmaniasis are scarce. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.006DOI Listing

"Penumbra sign" of Brodie's abscess.

Authors:
William F Wright

Braz J Infect Dis 2020 Apr 25. Epub 2020 Apr 25.

Johns Hopkins University School of Medicine, Department of Medicine, Division of Infectious Diseases, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bjid.2020.03.003DOI Listing

New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring.

Braz J Infect Dis 2020 Mar - Apr;24(2):120-129. Epub 2020 Apr 23.

Universidade Federal de Mato Grosso, Faculdade de Medicina, Cuiabá, MT, Brazil.

In recent years, the number of cases with severe Plasmodium vivax malaria has shown an increasing trend. It is, therefore, important to identify routine laboratory markers that best characterize the acute disease phase and can serve as a tool for clinical follow-up of patients. In a cohort study, we followed 87 patients with acute P. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.001DOI Listing

Deep impact of COVID-19 in the healthcare of Latin America: the case of Brazil.

Braz J Infect Dis 2020 Mar - Apr;24(2):93-95. Epub 2020 Apr 23.

Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19), Pereira, Colombia; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia. Electronic address:

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http://dx.doi.org/10.1016/j.bjid.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7177128PMC

COVID-19: a meta-analysis of diagnostic test accuracy of commercial assays registered in Brazil.

Braz J Infect Dis 2020 Mar - Apr;24(2):180-187. Epub 2020 Apr 18.

Fundação Oswaldo Cruz (FIOCRUZ), Instituto Nacional de Infectologia Evandro Chagas (INI), Rio de Janeiro, RJ, Brazil. Electronic address:

The accuracy of commercially available tests for COVID-19 in Brazil remains unclear. We aimed to perform a meta-analysis to describe the accuracy of available tests to detect COVID-19 in Brazil. We searched at the Brazilian Health Regulatory Agency (ANVISA) online platform to describe the pooled sensitivity (Se), specificity (Sp), diagnostic odds ratio (DOR) and summary receiver operating characteristic curves (SROC) for detection of IgM/IgG antibodies and for tests using naso/oropharyngeal swabs in the random-effects models. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165277PMC

Mobile genetic elements associated with carbapenemase genes in South American Enterobacterales.

Braz J Infect Dis 2020 Apr 21. Epub 2020 Apr 21.

Universidad San Francisco de Quito, Colegio de Ciencias Biológicas y Ambientales, Instituto de Microbiología, Quito, Ecuador.

Introduction: Carbapenem resistance in members of order Enterobacterales is a growing public health problem causing high mortality in developing and industrialized countries. Its emergence and rapid propagation worldwide was due to both intercontinental spread of pandemic strains and horizontal dissemination via mobile genetic elements (MGE) such as plasmids and transposons.

Objective: To describe MGE carrying carbapenem resistance genes in Enterobacterales which have been reported in South America. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.03.002DOI Listing
April 2020
1.096 Impact Factor

Tuberculosis associated with diabetes mellitus by age group in Brazil: a retrospective cohort study, 2007-2014.

Braz J Infect Dis 2020 Mar - Apr;24(2):130-136. Epub 2020 Apr 13.

UNITAID - WHO, Genova, Switzerland.

Diabetes mellitus (DM) has important implications for tuberculosis (TB), as it increases the risk for disease activation and is associated with unfavorable TB treatment outcomes. This study analyzed the association between TB and DM (TBDM) in Brazil from 2007 to 2014. This was a retrospective cohort study carried out in 709,429 new cases of TB reported to the national disease notification system of the Brazilian Ministry of Health. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.03.005DOI Listing

Pulmonary involvement in patients with measles.

Braz J Infect Dis 2020 Apr 10. Epub 2020 Apr 10.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.bjid.2020.03.004DOI Listing

Serum levels of matrix metalloproteinase-2, -9, and vitamin D in patients with multiple sclerosis with or without herpesvirus-6 seropositivity.

Braz J Infect Dis 2020 Mar - Apr;24(2):144-149. Epub 2020 Mar 31.

Hamadan University of Medical Sciences, Faculty of Medicine Hamadan, Department of Medical Virology, Hamadan, Iran. Electronic address:

In recent years, extreme attention has been focused on the role of human herpesvirus-6 (HHV-6) in multiple sclerosis (MS) pathogenesis. However, the pathogenesis of MS associated with HHV-6 infection remains unknown. In this study, we measured the serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and vitamin D levels in MS patients with HHV-6 infection and MS patients without HHV-6 infection. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.02.001DOI Listing

Infectious complications associated with parenteral nutrition in intensive care unit and non-intensive care unit patients.

Braz J Infect Dis 2020 Mar - Apr;24(2):137-143. Epub 2020 Mar 20.

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas: Endocrinologia, Porto Alegre, RS, Brazil; Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Serviço de Nutrologia, Porto Alegre, RS, Brazil.

Introduction: Malnutrition is associated with an increased risk of complications in hospitalized patients, and parenteral nutrition (PN) is used when oral or enteral feeding is not possible. This study aimed at analyzing associations between PN characteristics and infectious complications in hospitalized patients.

Material And Methods: This was a retrospective cohort study conducted in a tertiarycare university hospital. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.02.002DOI Listing

Novel coronavirus pneumonia.

Braz J Infect Dis 2020 Mar - Apr;24(2):178-179. Epub 2020 Mar 20.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Department of Infectious Diseases, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.bjid.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102601PMC
March 2020
1.096 Impact Factor

Efficacy and safety of dimeticones in the treatment of epidermal parasitic skin diseases with special emphasis on tungiasis: an evidence-based critical review.

Braz J Infect Dis 2020 Mar - Apr;24(2):170-177. Epub 2020 Feb 24.

Charité University Medicine, Institute of Microbiology and Infection Immunology, Berlin, Germany.

Epidermal parasitic skin diseases encompass scabies, pediculosis, cutaneous larva migrans, myiasis, and tungiasis. Tungiasis is probably the most neglected of all Neglected Tropical Diseases (NTD). It occurs in South America, the Caribbean and Sub-Saharan Africa and affects marginalized populations where people live in extreme poverty. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.01.004DOI Listing
February 2020
1.096 Impact Factor

Nicotinamide activates latent HIV-1 ex vivo in ART suppressed individuals, revealing higher potency than the association of two methyltransferase inhibitors, chaetocin and BIX01294.

Braz J Infect Dis 2020 Mar - Apr;24(2):150-159. Epub 2020 Feb 24.

Department of Medicine, Federal University of Sao Paulo, São Paulo, SP, Brazil. Electronic address:

Background: Latent HIV-1 is a major hurdle in obtaining HIV-1 sustained virological remission (SVR). Here we explored histone deacetylation inhibition property of nicotinamide (NAM; n=17) for the first time in comparison to a combination of methyltransferase inhibitors (MTIs; Chaetocin and BIX01294; n=25) to reactivate latent HIV ex vivo in CD8-depleted PBMCs from antiretroviral treated aviremic individuals.

Results: NAM reactivated HIV-1 from 13/17 (76. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.01.005DOI Listing
February 2020

Coagulase-negative staphylococci: a 20-year study on the antimicrobial resistance profile of blood culture isolates from a teaching hospital.

Braz J Infect Dis 2020 Mar - Apr;24(2):160-169. Epub 2020 Feb 19.

UNESP-Universidade Estadual Paulista, Instituto de Biociências de Boucatu, Departamento de Microbiologia e Imunologia, São Paulo, SP, Brazil.

The increasing rates of nosocomial infection associated with coagulase-negative staphylococci (CoNS) were the rationale for this study, aiming to categorize oxacillin-resistant CoNS species recovered from blood culture specimens of inpatients at the UNESP Hospital das Clínicas in Botucatu, Brazil, over a 20-year period, and determine their sensitivity to other antimicrobial agents. The mecA gene was detected in 222 (74%) CoNS samples, and the four types of staphylococcal chromosomal cassette mec (SCCmec) were characterized in 19.4%, 3. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.01.003DOI Listing
February 2020

Seroprevalence of chikungunya virus infection in five hospitals within Anyigba, Kogi State of Nigeria.

Braz J Infect Dis 2020 Jan - Feb;24(1):1-6. Epub 2020 Jan 27.

Kogi State University, Department of Microbiology, Anyigba, Nigeria.

Febrile illnesses in developing countries are often misdiagnosed as malaria or typhoid fever. Although arboviral infections have similar clinical symptoms, they are usually not screened because of limited resources and the fact that there are several viruses in this group. Chikungunya virus (CHIKV) has been isolated in parts of Nigeria, but there is no documented evidence of the infection in Kogi State. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.01.001DOI Listing

Thermotolerance of Histoplasma capsulatum at 40 °C predominates among clinical isolates from different Latin American regions.

Braz J Infect Dis 2020 Jan - Feb;24(1):44-50. Epub 2020 Jan 25.

Universidad Nacional Autónoma de México (UNAM), Facultad de Medicina, Departamento de Microbiología-Parasitología, Ciudad de México, Mexico. Electronic address:

The yeast phase of 22 Histoplasma capsulatum clinical isolates from Mexico, Argentina, Colombia, and Guatemala and three reference strains, one from Panama and two from the United States of America (USA), were screened for thermosensitivity characteristics using different analyses. Growth curves at 0, 3, 6, 12, 24, and 30 h of incubation at 37 and 40 °C, the growth inhibition percentage at 40 °C, and the doubling time at 37 and 40 °C were determined for all yeasts studied. Most of the isolates examined exhibited thermotolerant phenotypes at 40 °C, whereas a thermosensitive phenotype at 40 °C was only detected in the Downs reference strain from the USA. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.12.007DOI Listing

Diagnostic parameters and reliability of four rapid immunochromatographic tests for dengue 4.

Braz J Infect Dis 2020 Jan - Feb;24(1):58-64. Epub 2020 Jan 16.

Oswaldo Cruz Foundation, Evandro Chagas National Institute of Infectious Diseases, Laboratory of Clinical Epidemiology, Rio de Janeiro, RJ, Brazil.

Background: Although performance of rapid immunochromatographic tests (RITs) for dengue virus (DENV) serotypes 1, 2 and 3 is relatively settled, evidence on accuracy of RITs for DENV-4 are based on studies with small sample sizes and with discrepant results.

Objectives: To assess accuracy and inter-observer agreement of RITs targeting dengue nonstructural protein-1 (NS1) antigen - Dengue NS1-Bioeasy™, Dengue NS1 Ag Strip-Bio-Rad™, IVB Dengue Ag NS1-Orangelife™ and Dengue NS1-K130-Bioclin™ in DENV-4 samples.

Methods: Study sample (n = 324) included adults presenting at an emergency unit in Rio de Janeiro, Brazil, with fever of ≤72 h and two or more dengue symptoms. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.12.004DOI Listing

Influenza A and B in a cohort of outpatient children and adolescent with influenza like-illness during two consecutive influenza seasons.

Braz J Infect Dis 2020 Jan - Feb;24(1):73-80. Epub 2020 Jan 15.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Medicina Preventiva, São Paulo, SP, Brazil.

Introduction: Influenza is an important cause of morbimortality worldwide. Although people at the extremes of age have a greater risk of complications, influenza has been more frequently investigated in the elderly than in children, and inpatients than outpatients. Yearly vaccination with trivalent or quadrivalent vaccines is the main strategy to control influenza. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110568PMC

Septicemia in an immunocompetent adult in the Czech Republic caused by Corynebacterium diphtheriae nontoxigenic strain biotype mitis: emergence of invasive cases in Western Europe.

Braz J Infect Dis 2020 Jan - Feb;24(1):89-91. Epub 2020 Jan 9.

Department of Infectious, Parasitic and Tropic Diseases of the Hospital Na Bulovce and Second Faculty of Medicine, Charles University in Prague, Czech Republic.

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http://dx.doi.org/10.1016/j.bjid.2019.12.003DOI Listing

Sporadic human cutaneous anthrax outbreak in Shaanxi Province, China: report of two cases from 2018.

Braz J Infect Dis 2020 Jan - Feb;24(1):81-84. Epub 2020 Jan 9.

The Second Affiliated Hospital of Xi'an Jiaotong University, Department of Infectious Diseases, Xi'an, China; Xi'an Jiaotong University, The Second Affiliated Hospital, National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, Xi'an, China; Ministry of Education of China, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases, Xi'an, China. Electronic address:

China's compulsory annual livestock anthrax vaccination policy has remarkably reduced but not completely eradicated human anthrax infections. Herein we describe a sporadic human cutaneous anthrax outbreak involving two cases in 2018 in Shaanxi Province, both involving herdsman who dealt with unvaccinated and potentially sick cattle. Both patients showed Bacillus anthracis-positive blister smear and blood culture. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.12.002DOI Listing

Corrigendum to "Gastrointestinal mucormycosis post lung transplantation" [Braz J Infect Dis 23 (2019) 368-370].

Braz J Infect Dis 2020 Jan - Feb;24(1):92. Epub 2020 Jan 2.

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clinicas HCFMUSP, São Paulo, SP, Brazil.

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http://dx.doi.org/10.1016/j.bjid.2019.12.006DOI Listing
January 2020

Clinical and microbiological characteristics of cryptococcosis at an university hospital in China from 2013 to 2017.

Braz J Infect Dis 2020 Jan - Feb;24(1):7-12. Epub 2019 Dec 20.

Zhejiang University School of Medicine, The First Affiliated Hospital, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Hangzhou, Zhejiang, China. Electronic address:

Background: This study aims to explore the epidemiology, clinical profile and strain characteristics of cryptococcosis from 2013 to 2017 in a major teaching hospital in China.

Methods: Trends in antifungal drug susceptibility of 217 consecutive non-repetitive cryptococcal isolates collected from patients of an university hospital in China were analyzed between 2013 and 2017. Of those, 98 isolates were conserved for identification by internal transcribed spacer (ITS) sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) system. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.11.004DOI Listing

Measles, rubella, mumps and Toxoplasma gondii antibodies in saliva of vaccinated students of schools and universities in São Paulo City, Brazil.

Braz J Infect Dis 2020 Jan - Feb;24(1):51-57. Epub 2019 Dec 19.

Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, Laboratório de Protozoologia, São Paulo, SP, Brazil; Universidade de São Paulo, Escola de Medicina, Departamento de Patologia, São Paulo, SP, Brazil. Electronic address:

Introduction: Vaccines are well-established public health interventions with major impact on the prevalence of infectious diseases, but outbreaks are occurring frequently due to primary and secondary failures, despite high coverage. Surveillance of efficacy and duration of induced immunity is a difficult task as it requires invasive blood sampling in children and teenagers. Saliva can be an acceptable alternative source of IgG to assess vaccine efficacy and toxoplasmosis incidence. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.11.005DOI Listing

Proposal of a clinical score to stratify the risk of multidrug-resistant gram-negative rods bacteremia in cancer patients.

Braz J Infect Dis 2020 Jan - Feb;24(1):34-43. Epub 2019 Dec 15.

Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno" CEMIC, Departamento de Medicina, División de Enfermedades Infecciosas, Buenos Aires, Argentina.

Introduction: Multidrug-resistant gram-negative rods (MDR GNR) represent a growing threat for patients with cancer. Our objective was to determine the characteristics of and risk factors for MDR GNR bacteremia in patients with cancer and to develop a clinical score to predict MDR GNR bacteremia.

Material And Methods: Multicenter prospective study analyzing initial episodes of MDR GNR bacteremia. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.11.001DOI Listing

Differential replicative fitness of the four dengue virus serotypes circulating in Colombia in human liver Huh7 cells.

Braz J Infect Dis 2020 Jan - Feb;24(1):13-24. Epub 2019 Dec 13.

Universidad El Bosque, Grupo de Virología, Bogotá, Colombia.

Dengue has been a significant public health problem in Colombia since the simultaneous circulation of the four dengue virus serotypes. The replicative fitness of dengue is a biological feature important for virus evolution and contributes to elucidating the behavior of virus populations and viral pathogenesis. However, it has not yet been studied in Colombian isolates. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.11.003DOI Listing
April 2020
1.096 Impact Factor

Factors associated to modification of first-line antiretroviral therapy due to adverse events in people living with HIV/AIDS.

Braz J Infect Dis 2020 Jan - Feb;24(1):65-72. Epub 2019 Dec 10.

Universidade de Pernambuco, Programa de Pós-graduação em Ciências da Saúde, Recife, PE, Brazil.

Antiretroviral therapy (ART) has modified the outcome of patients with HIV infection, providing virological control and reducing mortality. However, there are several reasons as to why patients may discontinue their antiretroviral therapy, with adverse events being one of the main reasons reported in the literature. This is a case-control nested in a cohort of people living with HIV/AIDS, conducted to identify the incidence of ART modification due to adverse events and the associated factors, in two referral services in Recife, Brazil, between 2011 and 2014. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.11.002DOI Listing

Treatment of chronic hepatitis C in patients with chronic kidney disease with Sofosbuvir-basead regimes.

Braz J Infect Dis 2020 Jan - Feb;24(1):25-29. Epub 2019 Nov 21.

Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Aelgre, RS, Brazil. Electronic address:

Background: To analyze the effectiveness and the safety of Sofosbuvir-based regimens to treat patients with chronic hepatitis C virus (HCV) infection and chronic kidney disease (CKD).

Methods: A retrospective, observational study in patients with chronic HCV infection and CKD treated with Sofosbuvir-based regimens was performed. Liver fibrosis, comorbidities, HCV genotype and sustained virological resposnse (SVR) at 12th week post-treatment were evaluated. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.011DOI Listing

Epitope of dengue virus E protein detect human antibodies associated with mild disease: a potential peptide for vaccine development.

Braz J Infect Dis 2020 Jan - Feb;24(1):85-88. Epub 2019 Nov 21.

Universidad Autónoma de Yucatán, Centro de Investigaciones Regionales "Dr. Hideyo Noguchi", Laboratorio de Parasitología, Mérida, Mexico.

The antigenic potential of seven immunogenic peptides of the dengue virus was evaluated in the sera of patients with dengue confirmed by IgM/IgG serology. Antibodies IgM and IgG against dengue virus peptides were analyzed by ELISA in 31 dengue sero-positive and 20 sero-negative patients. The P5 peptide showed significant IgG immunoreactivity mostly in the sera of patients with dengue without warning signs in comparison with patients with dengue with warning signs, correlating with mild disease. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.009DOI Listing

Development and validation of a simple and rapid way to generate low volume of plasma to be used in point-of-care HIV virus load technologies.

Braz J Infect Dis 2020 Jan - Feb;24(1):30-33. Epub 2019 Nov 21.

Universidade Federal do Rio de Janeiro, Departamento de Genética-Instituto de Biologia, Rio de Janeiro, RJ, Brazil. Electronic address:

A new point-of-care HIV viral load, mPIMA HIV-1/2 VL, Abbott, USA, has been recently developed. This point-of-care viral load requires no skilled person to run and uses a small plasma volume (50μL). However, obtaining 50μL of plasma can be a challenge in limited resource settings. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.010DOI Listing
April 2020
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Human herpesvirus 6A active infection in patients with autoimmune Hashimoto's thyroiditis.

Braz J Infect Dis 2019 Nov - Dec;23(6):435-440. Epub 2019 Nov 18.

Shiraz University of Medical Sciences, School of Paramedical Sciences, Diagnostic Laboratory Sciences and Technology Research Center, Shiraz, Iran. Electronic address:

Background: Hypothyroidism due to Hashimoto's thyroiditis (HT) is the commonest autoimmune endocrine illness in which antibodies against thyroid organ result in inflammation. The disease has a complex etiology that involves genetic and environmental influences. Viral infections may be involved in triggering of the disease as their molecular mimicry enhance autoimmune responses. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.004DOI Listing

A consensus document for the clinical management of invasive fungal diseases in pediatric patients with hematologic cancer and/or undergoing hematopoietic stem cell transplantation in Brazilian medical centers.

Braz J Infect Dis 2019 Nov - Dec;23(6):395-409. Epub 2019 Nov 16.

Universidade Federal de São Paulo, Escola Paulista de Medicina, Disciplina de Infectologia, Brazil. Electronic address:

In the present paper we summarize the suggestions of a multidisciplinary group including experts in pediatric oncology and infectious diseases who reviewed the medical literature to elaborate a consensus document (CD) for the diagnosis and clinical management of invasive fungal diseases (IFDs) in children with hematologic cancer and those who underwent hematopoietic stem-cell transplantation. All major multicenter studies designed to characterize the epidemiology of IFDs in children with cancer, as well as all randomized clinical trials addressing empirical and targeted antifungal therapy were reviewed. In the absence of randomized clinical trials, the best evidence available to support the recommendations were selected. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.09.005DOI Listing
March 2020
1.096 Impact Factor

Catheter-related infection due to Papiliotrema laurentii in an oncologic patient: Case report and systematic review.

Braz J Infect Dis 2019 Nov - Dec;23(6):451-461. Epub 2019 Nov 16.

Universidade de Caxias do Sul (UCS), Caxias do Sul, RS, Brazil. Electronic address:

Background: Papiliotrema laurentii is one of several non-neoformans cryptococci that have rarely been associated with human infection, since it was previously considered saprophyte and thought to be non-pathogenic to humans. Nevertheless, increasing number of reports of human infection have emerged in recent years, mostly in oncologic patients.

Aim: To report a case of a female patient with pyloric obstructive cancer with a catheter-related Papiliotrema laurentii blood stream infection and systematically review the available evidence on P. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.005DOI Listing

FilmArray Meningitis/Encephalitis (ME) panel in the diagnosis of bacterial meningitis.

Braz J Infect Dis 2019 Nov - Dec;23(6):468-470. Epub 2019 Nov 16.

Senne Líquor Diagnóstico, São Paulo/SP, Brazil.

The precise diagnosis of bacterial meningitis is essential. Cytological and biochemical examination of cerebrospinal fluid (CSF) are not specific. Conventional methods for bacterial meningitis lack sensitivity or take too long for a final result. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.008DOI Listing

Ghost tablets mimicking intestinal parasite.

Braz J Infect Dis 2019 Nov - Dec;23(6):462-463. Epub 2019 Nov 14.

Universidad del Desarrollo, Facultad de Medicina Clínica Alemana, Clínica Alemana, Laboratorio Clínico, Santiago, Chile; Universidad del Desarrollo, Facultad de Medicina Clínica Alemana, Instituto de Ciencias e Innovación en Medicina (ICIM), Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.bjid.2019.10.006DOI Listing

Virus isolation and genotype identification of human respiratory syncytial virus in Guizhou Province, China.

Braz J Infect Dis 2019 Nov - Dec;23(6):427-434. Epub 2019 Nov 14.

Guizhou University, Guizhou Provincial People's Hospital, Department of Central Laboratory, GuiyangChina; Guizhou Provincial People's Hospital, NHC Key Laboratory of Pulmonary Immunological Diseases, Guiyang, China.

To investigate the genetic variation and molecular epidemiology characteristics of Human Respiratory Syncytial Virus (HRSV) in Guizhou Province, nasopharyngeal aspirates were collected from patients with acute respiratory infection (ARI) in Guizhou Provincial People's Hospital, from December 2017 to March 2018, and inoculated to Hep-2 cells to isolate HRSV. Cells that showed cytopathic effect (CPE) were then confirmed by indirect immunofluorescence assay and reverse transcription. The sequence of the PCR products was determined for HRSV isolates, and the genetic variation was analyzed. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.007DOI Listing

Hepatitis B viremia in HIV-coinfected individuals under antiretroviral therapy.

Braz J Infect Dis 2019 Nov - Dec;23(6):441-450. Epub 2019 Nov 9.

Universidade de São Paulo, Faculdade de Medicina, Departamento de Doenças Infecciosas e Parasitárias, São Paulo, SP, Brazil. Electronic address:

Background: Antiretroviral therapy (ART) has decreased AIDS incidence and mortality, rendering comorbidities, such as hepatitis B more relevant for people living with human immunodeficiency virus (HIV). Since antiretroviral drugs may also inhibit hepatitis B virus (HBV) replication, analyzing the impact of ART on management of hepatitis B in this population is important.

Objective: To assess HBV viremia among HIV/HBV coinfected individuals on ART and its associated factors. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.10.002DOI Listing
March 2020
1.096 Impact Factor