Search our Database of Scientific Publications and Authors

I’m looking for a

    8780 results match your criteria Bratislavske lekarske listy[Journal]

    1 OF 176

    Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro.
    Bratisl Lek Listy 2018 ;119(5):312-316
    Objectives: Nigella sativa oil and thymoquinone were comparatively tested in vitro for their effects on human cancer cell lines (glioma,T98; prostate, LnCaP) as well as mouse embryonic fibroblast cell lines (3T3), and for the induction of apoptosis.

    Methods: Individual cell lines were treated with thymoquinone and N. sativa oil for 24 and 48 hr. Read More

    Iron chelating ligand for iron overload diseases.
    Bratisl Lek Listy 2018 ;119(5):308-311
    Iron overloads are a serious clinical condition in the health of humans and are therefore a key target in drug development. In this study, iron(III) complex of 8-hydroxyquinoline-5 sulphonic acid was synthesized and structurally characterized in its solid state and solution state by FT-IR, UV-Vis, elemental analysis, magnetic susceptibility and 1H-NMR. The catalase activities of complex were investigated. Read More

    Helicobacter pylori can be related to carotid intima-media thickness, epicardial adipose tissue thickness and serum neutrophil gelatinase-associated lipocalin (NGAL) levels.
    Bratisl Lek Listy 2018 ;119(5):302-307
    Background: Helicobacter pylori (HP) affects the cardiovascular system. Our aim in this study was to evaluate, whether an infection with HP causes subclinical atherosclerosis.

    Methods: We included 90 patients with dyspeptic symptoms in this study. Read More

    Serum endocan level and the severity of spinal cord injury.
    Bratisl Lek Listy 2018 ;119(5):298-301
    Objective: To determine whether the endocan level may be related to the severity of spinal cord injury.

    Background: Several biomarkers were evaluated for this purpose, but endocan has never been studied before. It is correlated to endothelial dysfunction and ischemia, which are the characteristics of spinal cord injury in most cases. Read More

    Influence of perioperative hypothermia on blood clotting in children.
    Bratisl Lek Listy 2018 ;119(5):294-297
    Objectives: The decrease of body temperature is one of the causes of blood clotting disorders.

    Background: Accidental hypothermia during anesthesia is a common condition and children, especially newborns, are the most sensitive patients to the side effects of hypothermia.

    Methods: Web of Science, SCOPUS and PubMed search was performed to retrieve both original and review articles addressing both, hypothermia during surgery and coagulation disorder in pediatric patients. Read More

    The predictive value of risk indices for cardiac complications in living donor liver transplantation.
    Bratisl Lek Listy 2018 ;119(5):289-293
    Background And Aims: The American College of Surgeons' National Surgical Quality Improvement Program (NSQIP) risk tool and Revised Cardiac Risk Index (RCRI) are recommended tools for cardiovascular assessment before non-cardiac surgery to predict early postoperative cardiac morbidity and mortality. Their predictive value for postoperative cardiovascular morbidity and mortality after liver transplantation is unknown. We aimed to evaluate the validity of these two risk tools to predict early (30-day) cardiovascular complications and in-hospital all-cause mortality. Read More

    miRNA-138 regulates MLK3/JNK/MAPK pathway to protect BV-2 cells from H2O2-induced apoptosis.
    Bratisl Lek Listy 2018 ;119(5):284-288
    Background: miR-138 is one of the down-regulated miRNAs during acute spinal cord injury. Mixed lineage kinase 3 (MLK3), a key factor of jun N-terminal kinase (JNK)/mitogen-activated protein kinase (MAPK) pathway, is the target of miR-138. The aim of this study was to investigate the role of miR-138 in H2O2-treated BV-2 cells. Read More

    miRNA-489 as a biomarker in diagnosis and treatment of cervical cancer.
    Bratisl Lek Listy 2018 ;119(5):278-283
    miRNA-489 was shown to be a suppressor factor in many cancers, however, evidence on the effects and mechanism of miRNA-489 in progression of cervical cancer is limited. So we aimed to determine the function of miRNA-489 in cervical cancer proliferation and apoptosis in our present study. Interestingly, we found that miRNA-489 was significantly down-regulated in cervical cancer tissues. Read More

    Why is it necessary to examine retina when the patient suffers from aplastic anemia?
    Bratisl Lek Listy 2018 ;119(5):275-277
    Purposes: To inform about a case of Revesz syndrome (RS) with initial ophthalmological symptomatology of severe proliferative vitreoretinopathy of the left eye (LE). After the aplastic anemia had developed, RS was established. The exudative retinopathy was successfully treated with photocoagulation on the right eye (RE). Read More

    A novel fetal sequence patogenesis resulting in oral meningoencephalocele.
    Bratisl Lek Listy 2018 ;119(5):272-274
    Objectives: To analyze a rare triad of intracranial fetal pathologies and clinical study of the novel defined sequence pathogenesis based on prenatal and postmortem findings.

    Methods: Complex multidisciplinary clinical analysis and review of up-to-date literature.

    Results: In an 18-gestational-week fetus the screening ultrasound scan resembled the semilobar type of holoprosencephaly and oral tumor. Read More

    Labelling of individual ependymal areas in lateral ventricles of human brain: ependymal tables.
    Bratisl Lek Listy 2018 ;119(5):265-271
    Different types of ependymal areas were studied and labelled in the human brain lateral ventricle. Periventricular structures were included in coining the names of the ependymal areas because they represent a basic and stable part of brain nerve structures suitable for the sake of clarity of localization of the ependyma. The labelling of individual ependymal areas was composed from letters: "Lv" (lateral ventricle); "E" (ependymal area) and letters for abbreviations of the closest periventricular structure, e. Read More

    Structural assessment of myocardial infarction scars and left ventricular function with cardiac magnetic resonance imaging in patients at high risk of sudden cardiac death.
    Bratisl Lek Listy 2018 ;119(5):259-264
    Objectives: Results of qualitative and quantitative analyses of scars and LV (left ventricle) function acquired by means of cardiac magnetic resonance (CMR) were correlated with a subsequent occurrence of malignant ventricular arrhythmias in patients at high risk of sudden cardiac death (SCD).

    Methods: We have prospectively followed 47 patients (mean age 60 ± 11 years) who were hospitalized for an implantable cardioverter-defibrillator (ICD) implantation to prevent SCD. All post-MI patients had severe residual LV dysfunction (LVEF 33±14%). Read More

    Immunohistochemical study on antigen-presenting cells in healthy and carious human teeth.
    Bratisl Lek Listy 2018 ;119(4):249-253
    Class II major histocompatibility complex (MHC) antigen-presenting cells are associated with the early phase of the immune response. We have studied the distribution of class II-expressing cells in developing, healthy and carious human teeth to clarify, when human pulp acquires an immunologic defense potential and how this reacts to dental caries. Antigen-expressing cells were identified immunohistochemically with the following monoclonal antibodies: HLA-DR - for dendritic cells and CD68 - for macrophages. Read More

    Would Janus' view on HDL be useful?
    Bratisl Lek Listy 2018 ;119(4):245-248
    Low-density lipoprotein cholesterol (LDL-C) is generally considered to be pro-atherogenic and high-density lipoprotein cholesterol (HDL-C) to be anti-atherogenic. The clinical approach to the diagnostics and treatment of clinical manifestations of atherosclerosis is the examination of the lipid spectrum. In routine clinical practice, the effects of the HDL class are measured only by determining the concentration of HDL cholesterol. Read More

    The effect of intrathecal sufentanil preconditioning against myocardial ischemia-reperfusion injury.
    Bratisl Lek Listy 2018 ;119(4):240-244
    Objectives: We aimed to investigate the cardioprotective effect and hemodynamic response of intrathecally administered sufentanil on myocardial IR injury.

    Background: Sufentanil, mu opioid receptor agonist, intravenously administered during clinical and experimental studies, has been shown to have a cardioprotective effect on myocardial ischemia-reperfusion injury.

    Methods: Thirty-two New Zealand type rabbits, which were anesthetized, were divided into four equal groups: sham, ischemia-reperfusion, sufentanil and ischemia-reperfusion+sufentanil. Read More

    Lithium prevents cell apoptosis through autophagy induction.
    Bratisl Lek Listy 2018 ;119(4):234-239
    Objective: Bone marrow stromal stem cells (BMSCs) are widely used as an available source for cell therapy, tissue engineering, and cellular differentiation-based techniques. Therefore, it is necessary to apply a simple method through which BMSCs can be protected from cell apoptosis under tough conditions of cell differentiation. Lithium treatment is one of the simple methods in this regard. Read More

    Genetically engineered mesenchymal stromal cells in cancer gene therapy.
    Bratisl Lek Listy 2018 ;119(4):221-223
    Based on our experimental data, we aimed to emphasise the perspectives of the use of mesenchymal stromal cells (MSC) in the cancer gene therapy. On the other hand, we would like to point out factors which should be taken into consideration at their clinical use. In this review we define MSC as unique targets for targeted therapy. Read More

    Immunosenescence - the role in the immunotherapy of older population.
    Bratisl Lek Listy 2018 ;119(4):217-220
    With ageing of their populations, many societies are challenged with serious systemic diseases. One of the causes of these diseases could be the age-related defects in immune system termed immunosenescence. Immunosenescence is characterized by accumulation of memory and non-functional immune cells, impaired signalling due to restricted repertoire of receptors, overall pro-inflammatory environment and complete dysregulation of the immune system. Read More

    Alternative hypotheses related to Alzheimer's disease.
    Bratisl Lek Listy 2018 ;119(4):210-216
    Alzheimer's disease represents the most common form of dementia and belongs to the group of neurodegenerative disorders characterized by progressive loss of neurons in the central nervous system. In the pathogenesis of Alzheimer's disease several etiologic and pathogenic factors exist, which lead to the dysfunction of neurotransmitter systems and consequent cognitive decline. Last three decades have delivered a crucial progress leading to better understanding of Alzheimer's disease, however, the exact mechanisms of pathology remain unclear. Read More

    Inhibitory interneurons in Alzheimer's disease.
    Bratisl Lek Listy 2018 ;119(4):205-209
    Alzheimer's disease is currently the most common neurodegenerative disorder, characterized by distinct cognitive and sensory deficits. The underlying pathogenetic mechanisms, however, still remain elusive. How the molecular and morphological changes associated with Alzheimer's disease affect information processing in neuronal circuits and translate into cognitive dysfunction is unclear. Read More

    Structural aspects of Alzheimer's disease immunotherapy targeted against amyloid-beta peptide.
    Bratisl Lek Listy 2018 ;119(4):201-204
    Alzheimer's disease is the most prominent neurodegenerative disease and has no efficient therapies available so far. Immunotherapy against amyloid-β (Aβ) peptide is one of the currently tested therapeutic approaches. Here we have reviewed the available structural knowledge about antibodies tested as passive anti-Aβ immunotherapy in clinical trials. Read More

    Canakinumab as monotherapy for treatment of familial Mediterranean fever - first report in Central and Eastern Europe region.
    Bratisl Lek Listy 2018 ;119(4):198-200
    Autoinflammatory disorders (AID) are characterized by spontaneous attacks of acute inflammation with a broad spectrum of clinical symptoms. Ongoing inflammation and reoccurrence of acute flares can lead to the development of amyloidosis. One group of AID is represented by monogenic periodic fever syndromes while familial Mediterranean fever (FMF) is the most common form of AID from this group. Read More

    Preoperative platelet-to-lymphocyte ratio is a predictor of prognosis in patients with ampullary carcinoma.
    Bratisl Lek Listy 2018 ;119(3):180-186
    Aim: To emphasize the significance of the platelet-to-lymphocyte ratio (PLR) in estimating the postoperative prognosis or survival measures in patients with carcinoma of the ampulla of Vater.

    Methods: We retrospectively reviewed 82 patients, who underwent pancreaticoduodenectomy for ampullary carcinoma between July 2001 and April 2014. We investigated the predictive significance of the preoperative PLR for disease-free survival (DFS) or overall survival (OS). Read More

    Selected physicochemical properties of amniotic fluid according to week of pregnancy.
    Bratisl Lek Listy 2018 ;119(3):175-179
    Background: A hundred years ago, scientists believed that amniotic fluid is a yellowish hypotonic mixture of foetal urine and maternal transudate with peculiar odour. Current knowledge shows that it represents a dynamic, complex mixture of inorganic and organic compounds.

    Objectives: Despite modern technological procedures, information is still lacking about the composition and properties of amniotic fluid. Read More

    The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats.
    Bratisl Lek Listy 2018 ;119(3):167-174
    Aim: We investigated the effects of atorvastatin and N-acetyl cysteine in decreasing ischemia-reperfusion damage after detorsion of a volvulus of the cecum and ascending colon.

    Methods: Wistar albino rats (250-300 g) were divided into four groups. A cecal-ascending colon volvulus was created by the intestinal clockwise 720° rotation. Read More

    Astaxanthin effectiveness in preventing multiple sclerosis in animal model.
    Bratisl Lek Listy 2018 ;119(3):160-166
    Objective: The aim of the present study was to reveal the effect of therapeutic and prophylactic potential of astaxanthin in experimental autoimmune encephalomyelitis (EAE) as an acceptable model for the study of multiple sclerosis (MS).

    Background: Astaxanthin has powerful antioxidant activities as well as several essential biological functions while multiple sclerosis prevention is highly regarded by researchers.

    Methods: The astaxanthin potential in prevention of multiple sclerosis was examined in the chronic model of experimental autoimmune encephalomyelitis (EAE) by using female C57BL/6 mice induced with oligodendrocyte glycoprotein (MOG). Read More

    The relationship between hepatocytes and small bowel after early and short food restriction: What the results show in morphometry.
    Bratisl Lek Listy 2018 ;119(3):156-159
    The objective of this study was to evaluate the relationship between hepatocyte morphometry and small bowel architecture after early and short food restriction. Altogether 48 Hyplus broiler rabbits were divided into three groups. The control group was fed ad libitum (ADL) throughout the experiment (C). Read More

    Investigation of the effects of thymoquinone on erythrocyte deformability in sepsis treatment which created by cecal perforation in rat.
    Bratisl Lek Listy 2018 ;119(3):152-155
    Aim: We aimed to study the effects of thymoquinone on erythrocyte deformability in an experimental model of sepsis given before or after the initiation of the sepsis model.

    Method: The animals were grouped as (n = 6) control, nigella sativa, sepsis, sepsis group with administration of nigella sativa before sepsis development and sepsis group with nigella sativa administration after sepsis development. Cecal ligation and puncture model (CLP) was used to induce sepsis in the animals. Read More

    Neuronal regeneration in injured rat spinal cord after human dental pulp derived neural crest stem cell transplantation.
    Bratisl Lek Listy 2018 ;119(3):143-151
    Objective: This study aimed to analyze the effect of human Dental Pulp-Neural Crest Stem Cells (hDP-NCSCs) delivery on lesion site after spinal cord injury (SCI), and to observe the functional recovery after transplantation.

    Methods: Neural Crest Stem Cells (NCSCs) were isolated from human Dental Pulp (hDP). The experimental rat population was divided into four groups (n = 6/24). Read More

    The relationship between intracranial pressure and lactate/pyruvate ratio in patients with subarachnoid haemorrhage.
    Bratisl Lek Listy 2018 ;119(3):139-142
    Aim: The aim of this study was to analyse the relationship between intracranial pressure (intracranial pressure monitoring) and lactate pyruvate ratio (cerebral microdialysis) in patients with ruptured intracranial aneurysms.

    Methods: In a group of fifteen patients, intracranial pressure and lactate/pyruvate ratios were measured and logged in hourly intervals. The relationship between these two variables was subsequently analysed in two ways. Read More

    Tumour metabolic activity measured by fluorodeoxyglucose positron emission tomography for radiotherapy planning as a prognostic factor for locally advanced non-small cell lung cancer.
    Bratisl Lek Listy 2018 ;119(3):133-138
    Objectives: To analyse whether the maximum standardized uptake value of the positron emission tomography/computed tomography for radiotherapy planning was useful as a prognostic factor for tumour response and survival of patients with locally advanced non-small cell lung cancer.

    Background: Increased 18F-fluoro-2-deoxyglucose uptake by lung cancer cells, measured as the maximum standardized uptake value, has been reported to predict the biologic aggressiveness of both early and advanced non-small cell lung cancer.

    Methods: A prospective study was performed in 61 consecutive patients with unresectable stage IA-IIIB of non-small cell lung cancer. Read More

    Lipoprotein particle sizes in patients undergoing kidney transplantation.
    Bratisl Lek Listy 2018 ;119(3):130-132
    Asymptomatic atherosclerotic disease is prevalent in the middle-aged group of kidney transplant recipients. In order to improve the estimation of their cardiovascular risk, dyslipidaemia pattern is very important to be evaluated. Knowledge of the lipid particle spectrum in patients undergoing kidney transplantation could help the clinicians to timely start intervention and prevention of atherosclerosis with an early hypolipidemic statin treatment (Tab. Read More

    Multiple endocrine neoplasia 2A (MEN 2A) syndrome.
    Bratisl Lek Listy 2018 ;119(2):120-125
    Introduction: In the MEN 2A syndrome, which is the most common of the three types of MEN, three endocrine systems are affected simultaneously or subsequently by the development of tumours manifested by medullary thyroid gland carcinoma, pheochromocytoma (often bilateral) and hyperparathyroidism.

    Material And Methods: 27 patients from 3 families affected by MEN 2A syndrome were examined clinically (by detecting the effects of catecholamine overproduction), biochemically (screening for metanephrine and normetanephrine in the serum), visualization (CT, MRI, MIBG, PET CT) and some of them also genetically (DNA fragment analysis obtained by PCR amplification).

    Results: Familial incidence of pheochromocytoma was confirmed in 10 patients (4 males, 5 females and one girl) aged 6 to 54 years (average 22. Read More

    The effects of smoking on neutrophil/lymphocyte, platelet/ /lymphocyte ratios.
    Bratisl Lek Listy 2018 ;119(2):116-119
    Objective: The aim of this study was to compare the Neutrophil to Lymphocyte ratio (NLR), Platelet to Lymphocyte ratio (PLR) and Mean Platelet Volume to Platelet (MPV/Plt) ratio of smokers and non-smokers.

    Methods: Two hundred smokers and two hundred non-smoking healthy volunteers were enrolled in this study. Sociodemographic data and hematologic parameters of all patients were recorded. Read More

    Evaluation of fractalkine (FKN) and secreted frizzled-related protein 4 (SFRP-4) serum levels in patients with prediabetes and type 2 diabetes.
    Bratisl Lek Listy 2018 ;119(2):112-115
    Objective: The objective of this study is to compare serum levels of FKN and SFRP-4 in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), and type 2 diabetes mellitus (T2DM).

    Methods: A total of 152 patients presented to the endocrinology outpatient clinic of our hospital were included in the study. Eighty-two patients with a history of T2DM were assigned to the T2DM group. Read More

    Effects of complete water fasting and regeneration diet on kidney function, oxidative stress and antioxidants.
    Bratisl Lek Listy 2018 ;119(2):107-111
    Objective: The aim of the study was to observe the influence of 11-days complete water fasting (WF) and regeneration diet (RD) on renal function, body weight, blood pressure and oxidative stress.

    Background: Therapeutic WF is considered a healing method.

    Methods: Ten volunteers drank only water for 11 days, followed by RD for the next 11 days. Read More

    Role of autophagy in the progress of coronary total occlusion.
    Bratisl Lek Listy 2018 ;119(2):103
    Objective: In this study, we measured the level of autophagy enzyme in patients with coronary artery disease (CAD) and investigated whether the role of autophagy existed in the progress of coronary collateral and coronary total occlusion (TO).

    Methods: Overall, 115 participants were included in this study. They were divided into the three groups: group 1: patients had chronic TO (n=49); group 2: patients had acute TO such as myocardial infarction (n=36); and group 3: participants were normal controls (n=30). Read More

    Heart failure affects liver morphology and function. What are the clinical implications?
    Bratisl Lek Listy 2018 ;119(2):98-102
    Liver dysfunction in heart failure is common and usually clinically significant, especially in patients with advanced or severe acute heart failure. Lesions are caused by an impaired hepatic circulation due to congestion and hypoperfusion. Congestive lesions are more common and typically manifested by painful hepatomegaly and increased direct bilirubin and alkaline phosphatase. Read More

    Effect of leucine on NF-κB pathway in liver regeneration after partial hepatectomy in rats, as determined by miniarray analysis.
    Bratisl Lek Listy 2018 ;119(2):92-97
    Background: Although some amino acids are recognized to have favorable effects on the liver regeneration after partial hepatectomy (PH), molecular mechanisms underlying these effects are barely known.

    Objective: Our study was aimed to investigate the effects of valine, glutamine, and leucine amino acids on PH-induced NF-κB signal pathway. The research team studied Leucine in a rat model in vivo. Read More

    Neuroprotective effects of high-dose human albumin against traumatic spinal cord injury in rats.
    Bratisl Lek Listy 2018 ;119(2):86-91
    Background And Objectives: Human serum albumin (HA) is a unique multifunctional protein with neuroprotective properties. We aimed to delineate the mechanisms of HA-induced neuroprotection, supresses inflammatory response and lipid peroxidation after spinal cord injury (SCI).

    Methods And Study Design: Adult female Wistar rats weighing 210-250 g were used for the study. Read More

    The efficacy of ozone therapy in neonatal rats with hypoxic ischemic brain injury.
    Bratisl Lek Listy 2018 ;119(2):81-85
    Objectives: This study is aimed to determine the effect of ozone therapy in neonatal rats with experimentally induced hypoxic ischemic brain injury (HIBI).

    Methods: The study included 7-d-old male Wistar rats that were randomized to the sham, control, ozone 1, and ozone 2 groups. All rats except those in the sham group were kept in a hypoxia chamber, and then the rats in the control group were given 0. Read More

    CdS nanoparticles of different lengths induce differential responses in some of the liver functions of mice.
    Bratisl Lek Listy 2018 ;119(2):75-80
    Cadmium sulfide nanoparticles (CdS NPs) are one of important nanoparticle materials which are widely used in photoelectric production, but their potential health hazard to the liver is not clear. This study is aimed at exploring the possible mechanisms of liver injury induced by CdS NPs. Male mice were treated with nanoparticles of 110-130 nm and 80-100 nm cadmium sulfide. Read More

    Immunological evaluation of chitosan nanoparticles loaded with tetanus toxoid.
    Bratisl Lek Listy 2018 ;119(2):71-74
    Objectives: The present study was aimed at comparing tetanus toxoid (TT)‑loaded-chitosan nanoparticles with aluminum hydroxide as a common vaccine adjuvant.

    Background: Tetanus remains to be a major public health problem. Nanoparticles have been extensively used as immune adjuvants. Read More

    miR-16-1-3p targets TWIST1 to inhibit cell proliferation and invasion in NSCLC.
    Bratisl Lek Listy 2018 ;119(1):60-65
    In our study, the impact of miR-16-1-3p on cell proliferation and invasion in NSCLC was explored. miR-16-1-3p mimics were transfected to A549 cells for miR-16-1-3p overexpression. qRT- PCR and Western blot were applied to explore the relative expression of mRNA and protein in A549 cells. Read More

    Histopathological efficiency of amifostine in radiation‑induced heart disease in rats.
    Bratisl Lek Listy 2018 ;119(1):54-59
    Objective: Amifositine is a phosphorylated thiol that holds its radioprotective actions by several indirect mechanisms. The purpose of this study was to evaluate histopathologically whether amifositine administration prior to irradiation would have a long‑term protective effect on heart tissue in an experimental rat model.

    Methods: Single dose of 18 Gy radiation and sham radiation exposure were used in related groups. Read More

    Apelin-13 increased food intake with serum ghrelin and leptin levels in male rats.
    Bratisl Lek Listy 2018 ;119(1):47-53
    In this study, we aimed to explain the role of apelin-13 on body weight, food and water intake with serum leptin, ghrelin, neuropeptid Y (NPY) and peptid YY (PYY) levels in male rat. Thirty-two Sprague-Dawley male rats were used for the study. The rats were injected SP (0. Read More

    Blockade of miR-663b inhibits cell proliferation and induces apoptosis in osteosarcoma via regulating TP73 expression.
    Bratisl Lek Listy 2018 ;119(1):41-46
    Objective: This study aimed to investigate the exact role of miR-663b in osteosarcoma (OS) progression and further explore the underlying molecular mechanisms.

    Materials And Methods: The miR-663b expression in human OS cell lines was determined by qRT-PCR, and the results suggested that miR-663b was highly expressed in human OS cells. TargetScan was used to predict the potential targets of miR-663b, and the prediction was confirmed by dual-luciferase reporter assay. Read More

    The effects of resveratrol on hepatic oxidative stress in metabolic syndrome model induced by high fructose diet.
    Bratisl Lek Listy 2018 ;119(1):36-40
    Background: The purpose of this study was to evaluate probable protective effects of resveratrol treatment on hepatic oxidative events in a rat model of metabolic syndrome (MetS).

    Methods: Thirty-two male adult rats were randomly divided into 4 groups: control, fructose, resveratrol, and fructose plus resveratrol. To induce MetS, fructose solution (20 % in drinking water) was used. Read More

    1 OF 176