8,890 results match your criteria Bratislavske lekarske listy[Journal]


Evaluation of the relationship between neutrophil lymphocyte ratio and the most common bacterial urinary tract infections after transplantation.

Bratisl Lek Listy 2019;120(2):161-165

Objective: We aimed to evaluate the relationship between neutrophil lymphocyte ratio and the most common bacterial urinary tract infections after transplantation. We also assessed the frequency of bacterial infections, e.g. Read More

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http://dx.doi.org/10.4149/BLL_2019_026DOI Listing
January 2019
1 Read

Proclination-induced changes in the labial cortical bone thickness of lower incisors.

Bratisl Lek Listy 2019;120(2):155-160

Objectives: We sought to objectivize the overall alveolar bone thickness changes in lower incisors after orthodontic intervention.

Background: The effect of orthodontic treatment on the cortical bone, specifically the clinical implications of proclination-induced change, have long been a matter of dispute.

Methods: Cone-beam computed tomographs of 58 patients were obtained before and after treatment and labial cortical bone thickness and overall alveolus width were measured in sagittal sections in the distance of 3, 6, 9 and 12 mm apically from the cemento-enamel junction. Read More

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http://dx.doi.org/10.4149/BLL_2019_025DOI Listing
January 2019
1 Read

Investigation of THDOC effects on pathophysiological signs of Alzheimer's disease as an endogenous neurosteroid: inhibition of acetylcholinesterase and plaque deposition.

Authors:
H Saleh L Sadeghi

Bratisl Lek Listy 2019;120(2):148-154

Alzheimer's disease (AD) is an advanced neurodegenerative disorder greatly accompanied by acetylcholinesterase (AChE) activation and amyloid plaque deposition. Tetrahydrodeoxycorticosterone (THDOC) is an endogenous neurosteroid that is reduced in AD patient according to previous results. It has neuroprotective effects and plays important role in neurological diseases. Read More

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http://dx.doi.org/10.4149/BLL_2019_024DOI Listing
January 2019
1 Read

TNF receptor type 1 and TNF receptor type 2 mRNA expression was not associated with coronary artery disease in a group of Iranian Turks.

Bratisl Lek Listy 2019;120(2):144-147

Objectives: Present investigation was carried out to evaluate the mRNA level of TNF receptor type 1 (TNFR1) and TNF receptor type 2 (TNFR2) in peripheral-blood cells in patients with premature CAD over healthy controls.

Background: TNFα as a pleiotropic cytokine could be concerned in cardiovascular pathophysiology regarding its special effects on endothelial cells. TNFα exerts its activities through its receptors, TNFR1 and TNFR2. Read More

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http://dx.doi.org/10.4149/BLL_2019_023DOI Listing
January 2019

Evaluation of the substitutions in 212, 342 and 215 amino acid positions in binding site of organophosphorus acid anhydrolase using the molecular docking and laboratory analysis.

Bratisl Lek Listy 2019;120(2):139-143

Objective: Organophosphorus Acid Anhydrolase (OPAA) is used as one of the most important enzymes in the decontamination process of organophosphate compounds. In this study, we aimed to evaluate the effects of amino acid substitution in OPAA's substrate-binding site on its catalytic activity using the rational engineering strategy.

Methods: The native and three mutant forms of OPAA enzyme including 4ZWP, 4ZWU and Mut6 were studied using the docking technique toward parathion, paraoxon and R-VX compounds. Read More

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http://dx.doi.org/10.4149/BLL_2019_022DOI Listing
January 2019
1 Read

The role of selenium in bevacizumab induced cardiotoxicity.

Authors:
C R Oncel I S Ovey

Bratisl Lek Listy 2019;120(2):131-138

Objective: We investigated the role of selenium in bevacizumab induced cardiotoxicity and involvement of transient receptor potential vanilloid 1 (TRPV1) channels in cardiomyocytes.

Materials And Methods: All cells (Human cardiomyocyte cell line) were cultured at 37 °C. We divided the cells into seven groups as control, bevacizumab, bevacizumab + capsazepin, bevacizumab + selenium, bevacizumab + selenium + capsazepin, selenium and selenium + capsazepin groups. Read More

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http://dx.doi.org/10.4149/BLL_2019_021DOI Listing
January 2019

Role of Gal-3 and H-FABP in the early diagnosis of acute coronary syndrome.

Bratisl Lek Listy 2019;120(2):124-130

Objectives: We aimed to compare the plasma levels of biomarkers such as: serum Gal-3, H-FABP, cTnI, and CK-MB in patients, who were admitted to the emergency room with chest pain, and to determine whether these biomarkers have early diagnostic value of acute coronary syndrome (ACS).

Methods: The study was performed in 60 patients aged ≥ 18 years, who were admitted to emergency room. These patients were divided into 3 groups: patients with STEMI (group I, n = 20), patients with NSTEMI (group II, n = 20), and patients with USAP (group III, n = 20). Read More

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http://dx.doi.org/10.4149/BLL_2019_020DOI Listing
January 2019
1 Read

Effect of the nervous system on cancer: Analysis of clinical studies.

Bratisl Lek Listy 2019;120(2):119-123

Preclinical data have shown that neurotransmitters released in peripheral tissues from nerve endings may influence carcinogenesis, affect the tumor microenvironment, and directly potentiate both proliferation and migration of cancer cells. This stimulatory role of the nervous system in cancer initiation and progression has also been documented by clinical studies investigating the effect of attenuated signaling from nerves innervating cancer tissue. However, compared to preclinical studies, clinical studies are rarer and some of them have ambiguous results. Read More

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http://dx.doi.org/10.4149/BLL_2019_019DOI Listing
January 2019
14 Reads

Protective effect of melatonin and agomelatine on adriamycin-induced nephrotoxicity in rat model: a renal scintigraphy and biochemical study.

Authors:
H Aygun S S Gul

Bratisl Lek Listy 2019;120(2):113-118

Objective: We aimed to determine the possible protective effects of melatonin and agomelatine on an animal model of adriamycin nephrotoxicity by 99mTc DMSA renal scintigraphy and biochemical methods.

Methods: Ten weeks old 49 male Wistar rats were randomly separated into seven groups; namely control (CON), adriamycin (ADR), melatonin (MEL), agomelatine (AGO), melatonin + adriamycin (MEL+ADR), agomelatine + adriamycin (AGO+ADR) and melatonin + agomelatine + adriamycin (MEL+AGO+ADR) groups. Nephrotoxicity was induced by a three-dose of 18 mg/kg adriamycin, i. Read More

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http://dx.doi.org/10.4149/BLL_2019_018DOI Listing
January 2019
1 Read

Generation of a fluorescent oncoprotein in soluble form and its delivery into mammalian cells.

Bratisl Lek Listy 2019;120(2):106-112

Background: Protein fusion technology was widely used to improve expression, purification and solubility of the recombinant proteins expressed in E. coli for in vitro/in vivo delivery.

Methods: We developed a method for successful expression of soluble +36GFP-A2-E7 protein in E. Read More

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http://dx.doi.org/10.4149/BLL_2019_017DOI Listing
January 2019
3 Reads

NPHS2 gene sequencing results in children of the Azerbaijani population with different types of nephrotic syndrome caused by chronic glomerulonephritis.

Bratisl Lek Listy 2019;120(2):102-105

Objectives: The aim of the study was to determine the mutation of the podocin gene (NPHS2) in children with minimal changes diseases (steroid sensitive nephrotic syndrome (NS)) and steroid resistant NS.

Background: Despite the fact that the role of genetic factors is a well-known phenomenon, in NS there are still unknown aspects that are yet to be discovered. NS, type 2 is caused by NPHS2 gene and is characterised with proteinuria, minimal change disease on renal biopsy, poor response to steroid treatment, etc. Read More

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http://dx.doi.org/10.4149/BLL_2019_016DOI Listing
January 2019
1 Read

Inconsistencies in institutional review board decisions: A proposal to regulate the decision-making process.

Bratisl Lek Listy 2019;120(2):95-101

Medical sciences and medical technologies are developing in an enormous pace. The number of multi-site and multi- cultural clinical trials is increasing in line with this development. Yet, the increase in number brought about a problem, namely that of inconsistencies in institutional review board (IRB) decisions. Read More

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http://dx.doi.org/10.4149/BLL_2019_015DOI Listing
January 2019
1 Read

Ankle-brachial index in diabetic patients - which upper cut-off value is to be used?

Bratisl Lek Listy 2018;119(12):793-797

Objectives: In diabetic patients, there is a discrepancy in guidelines for ankle-brachial index (ABI) screening for peripheral arterial disease (PAD). While diabetes organizations suggest the value of upper limit of normal ABI to be 1.3, cardiologists recommend 1. Read More

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http://dx.doi.org/10.4149/BLL_2018_145DOI Listing
January 2018
1 Read

Type II deiodinase polymorphism: A potential risk factor of type 2 diabetes mellitus.

Bratisl Lek Listy 2018;119(12):790-792

ype 2 diabetes mellitus (T2DM) remains one of the most challenging global epidemics of the twenty-first century. It is estimated that more than 350 million people worldwide are affected by this metabolic disorder. It has many risk factors. Read More

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http://dx.doi.org/10.4149/BLL_2018_144DOI Listing
January 2018
10 Reads

Active surveillance of incidence and risk factors of hemolysis, elevated liver enzymes and low platelets syndrome in Slovakia.

Bratisl Lek Listy 2018;119(12):785-789

Objective: Hemolysis, Elevated Liver Enzymes, Low Platelets syndrome (HELLP syndrome) is one of the actively haunted maternal morbidity through Slovak Obstetric Survey System (SOSS), the organisation for surveillance of severe maternal morbidity and mortality in Slovakia.

Methods: The questionaires were sent in 55 Obstetric Units in Slovakia. The analyzed and here presented data had been collected cases those happened in the period from 1. Read More

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http://dx.doi.org/10.4149/BLL_2018_143DOI Listing
January 2018
2 Reads

First printed 3D heart model based on cardiac magnetic resonance imaging data in Slovakia.

Bratisl Lek Listy 2018;119(12):781-784

Objectives: To present our experience with initial fabrication of 3D printed model of heart from cardiac magnetic resonance (CMR) imaging data.

Methods: A 20-year-old patient with a congenital heart defect after a surgical correction underwent CMR imaging. A novel whole-heart CMR imaging sequence, not requiring gadolinium contrast material application, was performed. Read More

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http://dx.doi.org/10.4149/BLL_2018_142DOI Listing
January 2018

The role of kisspeptin on aromatase expression in breast cancer.

Bratisl Lek Listy 2018;119(12):776-780

Aim: Kisspeptin is a reproductive peptide hormone that has anti-metastatic roles in several cancer types including colon, lung, and brain cancer. However, in breast cancer, increasing of kisspeptin expression induces aggressiveness of tumors, which in turn exacerbates breast cancer prognosis.

Material And Methods: Breast cancer cell lines MCF7 and SKBR3 were cultured in MEM (phenol red free) containing 10 % fetal bovine. Read More

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http://dx.doi.org/10.4149/BLL_2018_141DOI Listing
January 2018

Is elevated triglyceride high density lipoprotein cholesterol ratio a risk factor that causes acute coronary syndrome to appear earlier?

Bratisl Lek Listy 2018;119(12):770-775

Background: The purpose of this study was to assess the relationship between the triglyceride/high density lipoprotein cholesterol ratio and the risk of acute myocardial infarction in young adults.

Patients And Methods: A total of 621 patients, who underwent coronary angiography (CAG) due to Myocardial Infarction (MI) at our hospital were included in this study. Demographic characteristics, risk factor profile, laboratory test results, electrocardiographic and CAG findings were assessed in the selected groups. Read More

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http://dx.doi.org/10.4149/BLL_2018_140DOI Listing
January 2018

Increased lipocalin-2 vs reduced oxytocin in relation with adiposity, atherogenicity and hematological indices in metabolic syndrome patients with and without prediabetes.

Bratisl Lek Listy 2018;119(12):762-769

Objectives: The neuropeptide hormone- Oxytocin (OXT) and glycoprotein Lipocalin-2 (LCN-2) are strongly associated with cardiometabolic risks of insulin resistance in metabolic syndrome (MetS) and prediabetes (preDM).

Methods: In a cross sectional design we aimed to compare and correlate plasma levels of OXT and LCN-2 and a set of clinical parameters, adiposity indices, atherogenicity indices, and hematological indices in 29 MetS/preDM individuals and 29 non-diabetic MetS subjects  vs 30 normoglycemic lean controls. Colorimetric enzymatic assays of biomarkers were procured. Read More

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http://dx.doi.org/10.4149/BLL_2018_139DOI Listing
January 2018

Crocin and voluntary exercise promote heart angiogenesis through Akt and ERK1/2 signalling in type 2 diabetic rats.

Bratisl Lek Listy 2018;119(12):757-761

signalling.

Methods: Animals were divided into 4 groups as follows: diabetes (Dia), diabetic-crocin (Dia-Cro), diabetic-voluntary exercise (Dia-Exe), diabetic-crocin-voluntary exercise (Dia-Cro-Exe). Type 2 diabetes was induced by high-fat diet (4 weeks) and injection of streptozotocin (STZ) (i. Read More

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http://dx.doi.org/10.4149/BLL_2018_138DOI Listing
January 2018
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The neuroprotective effects of 2-APB in rats with experimentally- -induced severe acute pancreatitis.

Bratisl Lek Listy 2018;119(12):752-756

Aim: The objective of this study was to determine the neuroprotective effects of 2-aminoethyl diphenyl-borinate (2-APB) on the brains of rats with experimentally-induced severe acute pancreatitis.

Materials And Methods: Thirty Spraque-Dawley male rats with an average weight of 200-250 grams were randomly divided into three groups. Group 1: Sham group, Group 2: Severe acute pancreatitis group, Group 3: Treatment group with severe acute pancreatitis, given 2 mg/kg 2-APB before pancreatitis onset. Read More

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http://dx.doi.org/10.4149/BLL_2018_137DOI Listing
January 2018
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TP53 rs1042522 and rs8064946 variants in myocardial infarction.

Bratisl Lek Listy 2018;119(12):747-751

Objective: This study investigated the hypothesis that the single nucleotide polymorphisms (SNPs) of TP53 gene are related to a risk of myocardial infarction.

Methods: The coding SNP at codon 72 (rs1042522) and non-coding rs8064946 SNP were genotyped by polymerase chain reaction with sequence specific primers in 205 Czech patients with myocardial infarction and 148 Czech control subjects.

Results: The distribution of both SNPs was in agreement with the Hardy-Weinberg equilibrium and was similar to other European populations. Read More

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http://dx.doi.org/10.4149/BLL_2018_136DOI Listing
January 2018

Subserosal localization of myenteric ganglia in normal human appendix: immunostaining with neuronal and glial markers.

Bratisl Lek Listy 2018;119(12):743-746

Objectives: Visualization of unexpected distribution of myenteric ganglia in normal human appendiceal wall by immunofluorescence.

Background: The myenteric plexus is located between the longitudinal and circular muscle layers of the GIT. However, recently the irregular distribution of myenteric ganglia was revealed in human appendix. Read More

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http://dx.doi.org/10.4149/BLL_2018_135DOI Listing
January 2018

Lipid emulsion-induced inhibition of apoptosis.

Authors:
J T Sohn

Bratisl Lek Listy 2018;119(11):736

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http://dx.doi.org/10.4149/BLL_2018_132DOI Listing
January 2018

Epidemiology and cost of burns in emergency department during Syrian civil war.

Bratisl Lek Listy 2018;119(11):731-735

Background: We aimed to emphasize the importance of regional hospitals' capacities and emergency services for burn patients in war and disaster situations, in addition to assessing the costs and clinical situations of seriously burned patients who have come to the emergency service due to the bomb and heater burst during the Syrian civil war.

Methods: In this study, we analyzed these 217 burn patients and analyzed these patients' data for retrospective analysis.

Results: Burn patients were more often seen during the winter months. Read More

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http://dx.doi.org/10.4149/BLL_2018_131DOI Listing
January 2018
1 Read

Protection with thymoquinone against formaldehyde-induced neurotoxicity in the rats.

Bratisl Lek Listy 2018;119(11):726-730

Introduction: This study aimed to investigate the neurotoxic damage of formaldehyde (FA), which is commonly used in medicine and industrial fields, for the hippocampus of rats and the protective role of thymoquinone (TQ) against this neurotoxicity.

Methods: There were five groups with eight rats in each. Two control groups were formed, in one of them physiological saline was applied and in the other one corn oil was applied. Read More

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http://dx.doi.org/10.4149/BLL_2018_129DOI Listing
January 2018

Protective effect of nebivolol on gentamicin-induced nephrotoxicity in rats.

Bratisl Lek Listy 2018;119(11):718-725

Objective: Nephrotoxicity is a major complication of gentamicin (GEN), which is widely used in the treatment of severe Gram-negative infections. As we know, treatment with nebivolol has been shown to decrease renal fibrosis and glomerular injury as well as improve endothelial dysfunction. Therefore, we evaluated the potential protective effect of nebivolol (NBV) against GEN-induced nephrotoxicity in rats. Read More

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http://dx.doi.org/10.4149/BLL_2018_128DOI Listing
January 2018
1 Read

The ameliorative effect of lutein on ovarian ischemia-reperfusion injury in rats.

Bratisl Lek Listy 2018;119(11):713-717

Objectives: The aim of our study is to investigate biochemical and histopathological effects of lutein on the ovarian ischemia-reperfusion (I/R) injury in rats.

Background: Reactive oxygen species and cytokines have a very important role in the pathogenesis of I/R injury. Lutein and its derivatives may show an anti-inflammatory effect in relation to the decrease in inflammatory cytokines and increase in antioxidant enzymes. Read More

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http://dx.doi.org/10.4149/BLL_2018_127DOI Listing
January 2018

A link between cytotoxicity in cell culture and gastrointestinal side effects of oral anticoagulants: bench-to-bedside.

Bratisl Lek Listy 2018;119(11):706-712

Objective: Warfarin and nonvitamin-K oral anticoagulants including dabigatran, rivaroxaban, and apixaban are commonly used in the prophylaxis and treatment of systemic embolism and deep vein thrombosis. In this study, we aimed to compare the cytotoxic effects of warfarin and new oral anticoagulants and to show a possible correlation between cell cytotoxicity and gastrointestinal side effects in the real-life setting.

Methods: L929 cells were incubated with test materials. Read More

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http://dx.doi.org/10.4149/BLL_2018_126DOI Listing
January 2018

Comparison of transfection efficiency of polymer-based and lipid-based transfection reagents.

Bratisl Lek Listy 2018;119(11):701-705

Objectives: In this study, the optimal dose of Lipofectamine 3000 and Turbofect to transfect adherent cell lines such as CHO-K1 and HEK293 cells in comparison with non-adherent H9T-cells with pEGFP-N1 and pCDH was identified.

Background: Lipofectamine 3000 is a new transfection reagent which is claimed to be more efficient than other transfection reagents like Turbofect. Transfection efficiency could be affected by the nature of target cell line and vector. Read More

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http://dx.doi.org/10.4149/BLL_2018_125DOI Listing
January 2018

Synergic and comparative effect of 5-fluorouracil and leucoverin on breast and colon cancer cells through TRPM2 channels.

Authors:
Y Guler I S Ovey

Bratisl Lek Listy 2018;119(11):692-700

Objectives: We aimed to reveal the role of 5-fluorouracil (5-FU) and Leucovorin (LV) along with transient receptor potential protein melastatin 2 (TRPM2) channels in breast and colon cancer cells during the treatment process.

Background: 5-FU and LV are widely used in breast and colon cancers for chemotherapy. It has been reported that the expression of TRPM2 channels increased intensively in cancer cells. Read More

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http://dx.doi.org/10.4149/BLL_2018_124DOI Listing
January 2018

Evaluation of the effect of BMSCs condition media and methylprednisolone in TGF-β expression and functional recovery after an acute spinal cord injury.

Bratisl Lek Listy 2018;119(11):684-691

The purpose of this experimental study is evaluation of the effect of BMSCs Condition Media and Methylprednisolone in TGF-β expression and functional recovery after acute spinal cord injury in adult wistar rat.

Material And Methods: After an acute spinal cord injury, MP and BMSC-CM were injected intraperitoneally and the recovery rate was evaluated by BBB and narrow beam test. Real time PCR, H[et]E staining, cavity formation and stereology was done after 12 weeks post injury. Read More

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http://dx.doi.org/10.4149/BLL_2018_123DOI Listing
January 2018

The vascular patterns of the posterior part of the circulus arteriosus cerebri (Willisi).

Bratisl Lek Listy 2018;119(11):679-683

Background: Various authors defined three patterns of the posterior part of the circulus arteriosus cerebri Willisi (CW) according to the diameter of the posterior communicating artery (PCoA) and the precommunicating segment of the posterior cerebral artery (P1). In the adult pattern, the P1 has a diameter larger than the non-hypoplastic PCoA. In the transitional pattern, the diameter of the PCoA is equal to that of the P1. Read More

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http://dx.doi.org/10.4149/BLL_2018_122DOI Listing
January 2018
6 Reads

An efficient induction protocol for deriving mature oligodendrocytes from human dental stem cells.

Bratisl Lek Listy 2019;120(1):86-88

Introduction: This study examined the process of deriving mature oligodendrocytes from human dental pulp stem cells (hDPSCs) via addition of cerebrospinal fluid (CSF).

Methods: The hDPSCs were cultured in the presence of retinoic acid and CSF. The oligodendrocytes were confirmed using immunocytochemistry for specific glial markers, namely Olig2 and MBP markers. Read More

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http://dx.doi.org/10.4149/BLL_2019_013DOI Listing
January 2019

The effect of melatonin on digoxin‑induced cardiac damage in cardiomyocytes.

Authors:
I S Ovey C R Oncel

Bratisl Lek Listy 2019;120(1):78-85

Objectives: Digoxin is a cardiac glycoside which is widely used in cardiovascular medicine. Oxidative stress, as well as intracellular Ca2+ overload, plays an important role in digoxin toxicity. Transient receptor potential vanilloid 1 (TRPV1) channels are found in cardiomyocyte cells and they are activated by reactive oxygen species. Read More

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http://dx.doi.org/10.4149/BLL_2019_012DOI Listing
January 2019

Is there a new pathway relationship between melatonin and FEZ1 in experimental rat model of Alzheimer's disease?

Bratisl Lek Listy 2019;120(1):70-77

Alzheimer's disease (AD) is a progressive neurodegenerative disease. This study was performed to determine the possible relationship between melatonin, which is known to play a role in the neuro-protective mechanism in AD, and fasciculation and elongation protein zeta 1 (FEZ1). Thirty male rats were included and separated into 3 groups (n = 10) as vehicle (artificial cerebrospinal fluid), streptozotocin (STZ) and STZ+melatonin (MLT). Read More

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http://dx.doi.org/10.4149/BLL_2019_011DOI Listing
January 2019
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Vaspin, neutrophil gelatinase-associated lipocalin and apolipoprotein levels in patients with psoriatic arthritis.

Bratisl Lek Listy 2019;120(1):65-69

Objectives: To examine the relationship between disease activity and vaspin, neutrophil gelatinase-associated lipocalin (NGAL) and apolipoprotein levels in patients with psoriatic arthritis (PsA).

Background: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis, which is related with psoriasis. Adipokines are the mediators which play a role in metabolic homeostasis and inflammatory conditions. Read More

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http://dx.doi.org/10.4149/BLL_2019_010DOI Listing
January 2019
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Endothelin 1, NF-κB, and ADAM-15 expression in diabetic foot wounds.

Authors:
R Atic E Deveci

Bratisl Lek Listy 2019;120(1):58-64

Objectives: The diabetic foot is an important and destructive complication of diabetes. This study examined 65 individuals (35 males, 30 females) diagnosed with diabetic foot with open wounds on their feet.

Methods: After washing the foot with isotonic solution, the wound was debrided and the excised tissues (diabetic dermis) were fixed with neutral buffered 10 % formalin solution. Read More

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http://dx.doi.org/10.4149/BLL_2019_009DOI Listing
January 2019
5 Reads

Volume regulation of muscle cells in the carp Cyprinus carpio in response to hypernatremia.

Bratisl Lek Listy 2019;120(1):52-57

Background: Hypernatremia supports the movement of water from the intracellular to the intercellular space. This shift leads to cells shrinkage and disruption of intracellular processes, representing risk factors of morbidity and mortality in clinical circumstances. On the other hand, hypernatremia triggers protective mechanisms that counteract damage of cells. Read More

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http://dx.doi.org/10.4149/BLL_2019_008DOI Listing
January 2019
4 Reads

Targeted next-generation sequencing in Slovak cardiomyopathy patients.

Bratisl Lek Listy 2019;120(1):46-51

Objectives: For the first time we used targeted next-generation sequencing to detect candidate pathogenic variants in Slovak cardiomyopathy patients.

Background: Targeted next-generation sequencing is considered to be the best practice in genetic diagnostics of cardiomyopathies. However, in Slovakia, with high cardiomyopathies prevalence of 1/440, the current diagnostic tests are still based on Sanger sequencing of a few genes. Read More

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http://dx.doi.org/10.4149/BLL_2019_007DOI Listing
January 2019
1 Read

In vitro vasoactive effects of dexmedetomidine on isolated human umbilical arteries.

Bratisl Lek Listy 2019;120(1):40-45

Objective: We aimed to investigate the vasoactive effects of dexmedetomidine on isolated human umbilical arteries and possible mechanisms involved.

Methods: Human umbilical artery strips were suspended in Krebs-Henseleit solution and dose-response curves were obtained for cumulative dexmedetomidine before and after incubation with different agents; propranolol, atropine, yohimbine, prazosin, indomethacin, verapamil. Effects of calcium on cumulative dexmedetomidine-induced contractions were also studied. Read More

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http://dx.doi.org/10.4149/BLL_2019_006DOI Listing
January 2019
1 Read

Induction of miR-31 causes increased sensitivity to 5-FU and decreased migration and cell invasion in gastric adenocarcinoma.

Bratisl Lek Listy 2019;120(1):35-39

Drug resistance is the main obstacle in the treatment of gastric cancer, the third most common cause of cancer-related death in the world. Due to their small size, easy entrance to cells and multiple targets, microRNAs (miRs) are considered novel and attractive targets. In the current study, parental MKN-45, MKN-45-control vector, and MKN-45-miR-31 populations were compared in terms of cell cycle transitions, migration, cell invasion, and proliferation. Read More

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http://dx.doi.org/10.4149/BLL_2019_005DOI Listing
January 2019

Dinuclear ruthenium(II) Schiff base complex: a first in vivo study in Swiss albino mice.

Bratisl Lek Listy 2019;120(1):26-34

Objectives: Dinuclear ruthenium(II) Schiff base complex was selected for in vivo study among many other novel metal-based compounds, because of its previously proved in vitro anticancer and antibacterial properties. The aim was to investigate the potential toxicity of this compound in animal model through biochemical and histopathological assessment.

Methods: Adult Swiss albino mice of both sexes were divided into high-dose and low-dose group that received a single intraperitoneal dose of ruthenium complex (175 mg/kg and 25 mg/kg, respectively) and one control group (vehicle only). Read More

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http://dx.doi.org/10.4149/BLL_2019_004DOI Listing
January 2019
1 Read

Adult neural stem cell isolation from whole rat brain and neurosphere culture and differentiation.

Bratisl Lek Listy 2019;120(1):19-25

Historically, it was thought that neurogenesis ceased by the end of development, but it is currently understood that neurogenesis continues throughout the life of an individual. This continued growth arises from neural stem or progenitor cells (NSCs) located in specific regions of the adult brain, including the subventricular zone and the dentate gyrus of the hippocampus. Increased understanding of the nature of these cells and their reaction to environmental stimuli is of paramount importance in the effort to discern their role and potential use in repair following neurological disruption. Read More

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http://dx.doi.org/10.4149/BLL_2019_003DOI Listing
January 2019

New principles of cancer therapy give new hope for oncological patients.

Bratisl Lek Listy 2019;120(1):15-18

The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". A number of therapeutic approaches are available for cancer treatment, including surgery, radiation, and other strategies, some of which have been awarded previous Nobel Prizes. Read More

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http://dx.doi.org/10.4149/BLL_2019_002DOI Listing
January 2019
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Can alpha-1-acid glycoprotein affect the outcome of treatment in a cancer patient?

Bratisl Lek Listy 2019;120(1):9-14

Alpha-1-acid glycoprotein (AGP) is a glycoprotein found in the alpha-1 globulin fraction of human plasma proteins. AGP is an important representative of acute-phase proteins. Although numerous articles have been devoted to AGP, its exact biological function remains obscure. Read More

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http://dx.doi.org/10.4149/BLL_2018_134DOI Listing
January 2019

Commemorating 50 years since the first heart transplantation in Bratislava - Czechoslovakia.

Authors:
G Silvay

Bratisl Lek Listy 2019;120(1):3-8

The first human-to-human heart transplantation in Czechoslovakia, and the 25th transplantation in the world, was performed in Bratislava, the second largest city in Czechoslovakia on July 9, 1968. The operation was carried out by a team led by Professors Karol Siska and Ladislav Kuzela at the second Surgical Clinic at the Comenius University of the Medical Faculty in Bratislava, Partizanska Street-only seven months after the first heart transplantation performed by Dr. Christiaan Barnard in Cape Town. Read More

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http://dx.doi.org/10.4149/BLL_2019_001DOI Listing
January 2019

Continuous metabolic syndrome score (siMS) enables quantification of severity of cardiometabolic affliction in individuals not presenting with metabolic syndrome.

Authors:
K Sebekova J Sebek

Bratisl Lek Listy 2018;119(11):675-678

Assessment of degree of cardiometabolic affliction in subjects not presenting with metabolic syndrome (MS) yet, would be helpful in the management of preventive health maintenance.

Objectives: To evaluate continuous metabolic syndrome score (siMS) in estimation of severity of cardiometabolic affliction in individuals not presenting with MS.

Methods: We analyzed data from 3166 volunteers (56 % females) aged ≥ 16 years. Read More

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http://dx.doi.org/10.4149/BLL_2018_121DOI Listing
January 2018