190 results match your criteria Brain tumor research and treatment[Journal]


Conus Medullaris Teratoma: Case Report and Literature Review.

Brain Tumor Res Treat 2020 Jun 29. Epub 2020 Jun 29.

Department Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Teratomas are benign germ cell tumors that usually found out of their anatomical origin. Teratomas usually are found in sacrococcygeal area, gonads, mediastinum, cervicofacial region and intracranial fossa. Spinal teratomas are rare. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e14DOI Listing

A Case of Intracranial Solitary Fibrous Tumor/Hemangiopericytoma Repeatedly Misdiagnosed as Hypertensive Intracerebral Hemorrhage.

Brain Tumor Res Treat 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, Wonkwang University School of Medicine, Iksan, Korea.

Because solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) contain identical genetic abnormalities, the World Health Organization coined the term SFT/HPC to describe these lesions. Here, we present a rare case of SFT/HPC in a 40-year-old man with massive repeated intracranial hemorrhage (ICH) in right medial temporal lobe. ICHs from a SFT/HPC were repeatedly misdiagnosed as hypertensive ICH by several departments and hospitals over approximately eight months, and the patient underwent inappropriate treatments. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e13DOI Listing

Effect of Cumulative Dexamethasone Dose during Concomitant Chemoradiation on Lymphopenia in Patients with Newly Diagnosed Glioblastoma.

Brain Tumor Res Treat 2020 Jun 29. Epub 2020 Jun 29.

Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Lymphopenia frequently occurs after concomitant chemoradiation (CCRT) in patients with glioblastoma (GBM) and is associated with worse overall survival (OS). A few studies have tried to identify risk factors for lymphopenia; however, the results were not clear. We aimed to identify potential risk factors for lymphopenia, focusing on the use of dexamethasone to control cerebral edema in patients with GBM. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e12DOI Listing

Clinical Experience of Bevacizumab for Radiation Necrosis in Patients with Brain Metastasis.

Brain Tumor Res Treat 2020 Jul 9. Epub 2020 Jul 9.

Neuro-Oncology Clinic, National Cancer Center Korea, Goyang, Korea.

Background: As the application of radiotherapy to brain metastasis (BM) increases, the incidence of radiation necrosis (RN) as a late toxicity of radiotherapy also increases. However, no specific treatment for RN is indicated except long-term steroids. Here, we summarize the clinical results of bevacizumab (BEV) for RN. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e11DOI Listing

Pineal Cyst Apoplexy: A Rare Complication of Common Entity.

Authors:
El Kim Sae Min Kwon

Brain Tumor Res Treat 2020 Apr;8(1):66-70

Department of Neurosurgery, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.

Pineal cysts (PCs) are often encountered as incidental findings in intracranial images. The vast majority of cysts are normally asymptomatic and clinically benign. Bleeding into the cysts, which leads to neurological symptoms and signs, is considered to be quite rare. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221466PMC

An Intracerebral Type of Cranial Chondroma.

Authors:
El Kim

Brain Tumor Res Treat 2020 Apr;8(1):62-65

Department of Neurosurgery, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea.

The vast majority of intracranial chondromas are located in the base of the cranium. Their presentation as an intracerebral neoplasm is considered to be extremely rare. A previously healthy 45-year-old man experienced recurrent seizure attacks over a period of 6 months. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221463PMC

Sinonasal Teratocarcinosarcoma, a Rare Tumor Involving Both the Nasal Cavity and the Cranial Cavity.

Brain Tumor Res Treat 2020 Apr;8(1):57-61

Department of Pathology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea.

Sinonasal teratocarcinosarcoma (SNTCS), a very rare tumor, is known to be a heterogeneous with epithelial, mesenchymal, and neuroepithelial components and shows a very aggressive clinical course. Due to the heterogeneity of this tumor, it is often misdiagnosed. No definitive treatment modality has been reported because it is a very rare tumor. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221467PMC

Primary Gliosarcoma with Extracranial Metastasis.

Brain Tumor Res Treat 2020 Apr;8(1):53-56

Department of Neurosurgery, Daegu Fatima Hospital, Daegu, Korea.

A 69-year-old male presented with a week of worsening headache, mild dizziness and left side weakness, and the radiological work-up of his brain displayed an enhancing mass on the right frontal lobe. The tumor was totally resected. The patient was initially diagnosed with glioblastoma multiforme. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221469PMC

Inhibition of the Spectraplakin Protein Microtubule Actin Crosslinking Factor 1 Sensitizes Glioblastomas to Radiation.

Brain Tumor Res Treat 2020 Apr;8(1):43-52

Department of Biological Sciences, Tennessee State University, Nashville, TN, USA.

Background: Microtubule actin crosslinking factor 1 (MACF1) is a spectraplakin cytoskeletal crosslinking protein whose function and role in cancer biology has lacked investigation. Recent studies have identified MACF1 as a novel target in glioblastomas expressed in tissue from tumor patient explants but not normal brain tissue and when silenced has an antitumorigenic impact on these tumors. Radiation as a single agent therapy to treat glioblastomas has been used for decades and has done little to improve survival of individuals diagnosed with this disease. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221465PMC

Comparison of Diagnostic Performance of Two-Dimensional and Three-Dimensional Fractal Dimension and Lacunarity Analyses for Predicting the Meningioma Grade.

Brain Tumor Res Treat 2020 Apr;8(1):36-42

Department of Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.

Background: To compare the diagnostic performance of two-dimensional (2D) and three-dimensional (3D) fractal dimension (FD) and lacunarity features from MRI for predicting the meningioma grade.

Methods: This retrospective study included 123 meningioma patients [90 World Health Organization (WHO) grade I, 33 WHO grade II/III] with preoperative MRI including post-contrast T1-weighted imaging. The 2D and 3D FD and lacunarity parameters from the contrast-enhancing portion of the tumor were calculated. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221468PMC

Re-Irradiation and Its Contribution to Good Prognosis in Recurrent Glioblastoma Patients.

Brain Tumor Res Treat 2020 Apr;8(1):29-35

Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine, Seongnam, Korea.

Background: Radiation therapy, one of the strongest anti-cancer treatments, is already performed to treat primary glioblastoma; however, the effect of repeated radiation therapy for recurrent tumors has not been fully explored. The aim of this study was to determine the efficacy of re-irradiation in treating recurrent glioblastoma.

Methods: The study included 36 patients with recurrent glioblastoma treated with repeated radiation therapy between 2002 and 2016. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221471PMC

A National Consensus Survey for Current Practice in Brain Tumor Management III: Brain Metastasis and Primary Central Nervous System Lymphoma.

Brain Tumor Res Treat 2020 Apr;8(1):20-28

Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.

Background: The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted the nationwide questionnaire survey for diverse queries facing to treat patients with brain tumor. As part III of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with brain metastasis and primary central nervous system lymphoma (PCNSL).

Methods: A web-based survey was sent to all members of the KSNO by email. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221464PMC

A National Consensus Survey for Current Practice in Brain Tumor Management II: Diffuse Midline Glioma and Meningioma.

Brain Tumor Res Treat 2020 04;8(1):11-19

Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.

Background: The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted a nationwide questionnaire survey for diverse queries faced in the treatment of brain tumors. As part II of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with diffuse midline glioma and meningioma.

Methods: A web-based survey was sent to all members of the KSNO by email. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221470PMC

A National Consensus Survey for Current Practice in Brain Tumor Management I: Antiepileptic Drug and Steroid Usage.

Brain Tumor Res Treat 2020 Apr;8(1):1-10

Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.

Background: The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted a nationwide questionnaire survey for diverse queries faced in the treatment of brain tumors. As part I of the survey, the aim of this study is to evaluate national patterns of clinical practice about antiepileptic drug (AED) and steroid usage for management of brain tumors.

Methods: A web-based survey was sent to all members of the KSNO by email. Read More

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http://dx.doi.org/10.14791/btrt.2020.8.e5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221462PMC

A Case of Primary Central Nervous System Vasculitis That Worsened Despite Early Corticosteroid Therapy.

Brain Tumor Res Treat 2019 Oct;7(2):164-167

Department of Pathology, Kyungpook National University School of Medicine, Kyungpook National University Chilgok Hospital, Daegu, Korea.

Primary central nervous system vasculitis (PCNSV) is rare, and the diagnosis is difficult to make because of its variable radiologic expressions. Early corticosteroid therapy often is effective. Herein we report the case of a 56-year-old man who had a well-enhanced cystic mass with severe edema in the right frontal lobe, which was initially felt to be a malignancy. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e37DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829087PMC
October 2019
1 Read

Intratumoral Hemorrhage of the Cervical Spinal Schwannoma Presenting: Acute Quadriparesis.

Brain Tumor Res Treat 2019 Oct;7(2):160-163

Department of Neurosurgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Schwannomas are the most common extramedullary spinal tumors, with chronic progressive symptoms being the most common presenting features. The acute hemorrhagic onset of a spinal schwannoma is a rare occurrence. Here, we report the case of a 37-year-old male who presented with complaint of neck pain and an acute onset of quadriparesis. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829079PMC
October 2019

Angioleiomyoma in the Orbital Apex: A Case Report.

Brain Tumor Res Treat 2019 Oct;7(2):156-159

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

A 56-year woman presented eyeball pain and blurred vision. MRI revealed a small well-delineated solid tumor in the apex of right orbit with optic nerve compression. Intraoperatively, the tumor was found very fibrous, hypervascular and adhesive to surrounding structures. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829078PMC
October 2019

Lateral Ventricular Meningioma Presenting with Intraventricular Hemorrhage.

Brain Tumor Res Treat 2019 Oct;7(2):151-155

Department of Neurosurgery, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

A 35-year-old female visited emergency department for a sudden onset of headache with vomiting after management for abortion at local department. Neurological examination revealed drowsy mentality without focal neurological deficits. CT showed 3. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e41DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829083PMC
October 2019

A Case of Sporadic Suprasellar Hemangioblastoma Mimicking Meningioma.

Brain Tumor Res Treat 2019 Oct;7(2):147-150

Department of Neurosurgery, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.

Hemangioblastoma (HBL) in the suprasellar region is very rare and a few cases have been reported. Suprasellar HBL without von Hippel-Lindau disease is much rarer. A 76-year old male patient presented progressively deteriorating visual disturbance. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829077PMC
October 2019

Found at Old Age and Continuously Growing WHO Grade II Fourth Ventricle Ependymoma: A Case Report.

Brain Tumor Res Treat 2019 Oct;7(2):141-146

Department of Cancer Control, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, Korea.

A 74-year-old woman presented with a month-long nausea and vomiting, then she could not take a meal. She had found an asymptomatic 4th ventricular mass 6 year ago as a preoperative work-up for ovarian cancer. And during the yearly follow-up, the mass had grown continuously over 6 years, and caused symptoms in the seventh year. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829090PMC
October 2019
1 Read

Discordance of Epidermal Growth Factor Receptor Mutation between Brain Metastasis and Primary Non-Small Cell Lung Cancer.

Brain Tumor Res Treat 2019 Oct;7(2):137-140

Neuro-Oncology Clinic, National Cancer Center Hospital, Goyang, Korea.

Background: The aim of this study was to compare epidermal growth factor receptor (EGFR) mutations between non-small cell lung cancer (NSCLC) and corresponding brain metastases (BMs) in Korea society.

Methods: From 2011 to 2016, a total of 74 patients underwent surgical resection of a metastatic brain tumor from NSCLC. Among them, we performed retrospective analysis for 46 patients who underwent EGFR sequencing of primary NSCLC tissues. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e44DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829080PMC
October 2019
1 Read

The Effect of Pain Reduction during Headframe Fixation for Stereotactic Radiosurgery by the Preceded Local Anesthesia under the Needle Cap Guidance.

Brain Tumor Res Treat 2019 Oct;7(2):132-136

Department of Neurosurgery & Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.

Background: Gamma knife radiosurgery (GKRS) has become a major alternative in the neurosurgical field. However, many patients complained of considerable discomfort during the fixation of rigid headframe. This study investigated whether our modified procedure could reduce fixation-related pain. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829085PMC
October 2019

Racial Differences in Hospital Stays among Patients Undergoing Craniotomy for Tumour Resection at a Single Academic Hospital.

Brain Tumor Res Treat 2019 Oct;7(2):122-131

Department of Neurosurgery, Ronald Reagan UCLA Medical Center of the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.

Background: Racial differences in American patients undergoing brain tumour surgery remain poorly characterized within urban medical centres. Our objective was to assess racial differences in operative brain tumour patients at a single academic hospital in Los Angeles, California.

Methods: We reviewed medical records of adult patients undergoing craniotomy for tumour resection from March 2013 to January 2017 at UCLA Medical Centre. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829091PMC
October 2019
1 Read

Demographic and Socioeconomic Factors for Renouncing Further Active Therapy for Patients with Brain Metastasis of Non-Small Cell Lung Cancer.

Brain Tumor Res Treat 2019 Oct;7(2):112-121

Division of Neuro-Oncology and Department of Neurosurgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Background: As patients with brain metastasis (BM) of non-small cell lung cancer (NSCLC) have dismal prognosis, some of them decide to discontinue further treatment for BM. The objective of this study was to determine factors for renouncing further active therapy in patients with BM of NSCLC, focusing on their demographic and socioeconomic status.

Methods: Medical records of 105 patients with radiological diagnosis of BM of NSCLC for the recent 11 years at authors' institution were retrospectively reviewed. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829092PMC
October 2019

Experience Profiling of Fluorescence-Guided Surgery II: Non-Glioma Pathologies.

Brain Tumor Res Treat 2019 Oct;7(2):105-111

Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

Background: Only sporadic reports of fluorescence-guided surgery (FGS) have been published for non-glioma conditions. In this study, we focus on epidemiological data of fluorescence patterns and report the diverse experiences of FGS in non-gliomas.

Methods: During 8. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829089PMC
October 2019
1 Read

Experience Profiling of Fluorescence-Guided Surgery I: Gliomas.

Brain Tumor Res Treat 2019 Oct;7(2):98-104

Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.

Background: Numerous studies reported a usefulness of 5-aminolevulinic acid (5-ALA) fluorescence-guided surgery (FGS) in high grade gliomas. However, fluorescence patterns and intensities are variable among gliomas. In this study, we report our extensive experience with FGS in various gliomas, focusing on epidemiological data of fluorescence patterns. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829086PMC
October 2019

Survival and Prognosis of Patients with Pilocytic Astrocytoma: A Single-Center Study.

Brain Tumor Res Treat 2019 Oct;7(2):92-97

Department of Pediatrics, Keimyung University School of Medicine, Keimyung University Dongsan Medical Center, Daegu, Korea.

Background: Pilocytic astrocytoma (PA) is a brain tumor that is relatively more common in children and young adults.

Methods: We retrospectively reviewed the medical records of patients with PA treated at a single center between 1988 and 2018.

Results: We included 31 subjects with PA. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829088PMC
October 2019

Efficacy of Slow Rate Ventriculolumbar Perfusion Chemotherapy for Leptomeningeal Carcinomatosis: Interim Result of a Phase II Study.

Brain Tumor Res Treat 2019 Oct;7(2):85-91

Neuro-Oncology Clinic, National Cancer Center, Goyang, Korea.

Background: To evaluate the efficacy of modified ventriculolumbar perfusion (VLP) chemotherapy with methotrexate on leptomeningeal carcinomatosis in terms of symptomatic response and side effects.

Methods: Previous infusion rate of 20 mL/h was reduced to 15 mL/h for the purpose of decreasing constitutional side effects of VLP such as nausea/vomiting, insomnia and confusion. The primary outcome was the response rate of increased intracranial pressure (ICP), and the secondary outcome was the occurrence of side effects compared to previous 20 mL/h trial. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e33DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829082PMC
October 2019
1 Read

The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade II Cerebral Gliomas in Adults: Version 2019.01.

Brain Tumor Res Treat 2019 Oct;7(2):74-84

Department of Neurosurgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.

Background: There was no practical guideline for the management of patients with central nervous system tumor in Korea for many years. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, has developed the guideline for glioblastoma. Subsequently, the KSNO guideline for World Health Organization (WHO) grade II cerebral glioma in adults is established. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829081PMC
October 2019

The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade III Cerebral Gliomas in Adults: Version 2019.01.

Brain Tumor Res Treat 2019 Oct;7(2):63-73

Department of Neurosurgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.

Background: There was no practical guideline for the management of patients with central nervous system tumor in Korea in the past. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, developed the guideline for glioblastoma successfully and published it in , the official journal of KSNO, in April 2019. Recently, the KSNO guideline for World Health Organization (WHO) grade III cerebral glioma in adults has been established. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829084PMC
October 2019

Idiopathic Granulomatous Hypophysitis with Rapid Onset: A Case Report.

Brain Tumor Res Treat 2019 Apr;7(1):57-61

Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.

Idiopathic granulomatous hypophysitis (IGH), a rare disease, requires differentiation from more common mass lesions of the sella such as pituitary adenoma, craniopharyngioma, Rathke's cleft cyst, or pituitary tuberculoma. IGH usually presents with an insidious onset of visual defects and headaches. On the other hand, rapid onset of neurologic and visual symptoms in an IGH patient is exceptionally rare. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504759PMC
April 2019
14 Reads

Primary Intraparenchymal Central Nervous System Solitary Fibrous Tumor/Hemangiopericytoma Presenting with Intracerebral Hemorrhage: A Case Report.

Brain Tumor Res Treat 2019 Apr;7(1):53-56

Department of Pathology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Hwasun, Korea.

A 53-year old man who had a left hemiparesis from head injury of traffic accident 20 years ago visited an emergency room with suddenly developed semi-comatose mental status. Brain CT showed 8.6-cm sized solid and cystic mass on right temporal lobe that was associated with hemorrhage. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504755PMC
April 2019
7 Reads

Choroid Plexus Carcinoma in Adults: Two Case Reports.

Brain Tumor Res Treat 2019 Apr;7(1):48-52

Deaprtment of Cancer Control, National Cancer Center, Graduate School of Cancer Science and Policy, Goyang, Korea.

Choroid plexus tumors are uncommon brain tumors that primarily occur in children. Most of these tumors originate from the intraventricular area, and the most common clinicalpresentation is increased intracranial pressure. Dissemination through the cerebrospinal fluid space is the inevitable natural course of the disease. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504752PMC
April 2019
4 Reads

A Case of Recurrent Supratentorial Extraventricular Anaplastic Ependymoma in Adult.

Brain Tumor Res Treat 2019 Apr;7(1):44-47

Department of Neurosurgery, Daegu Fatima Hospital, Daegu, Korea.

Supratentorial extraventricular anaplastic ependymoma (SEAE) in adults is a relatively rare intracranial tumor. Because of the very low prevalence, only a few cases have been reported. According to a recent study, SEAE is associated with a poor prognosis and there is no definite consensus on optimal treatment. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2019.
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http://dx.doi.org/10.14791/btrt.2019.7.e26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504761PMC
April 2019
22 Reads

Extensive Pachymeningeal Dissemination of Glioblastoma Mimicking Chronic Subdural Hematoma: A Case Report.

Brain Tumor Res Treat 2019 Apr;7(1):39-43

Division of Neurooncology and Department of Neurosurgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.

Meningeal dissemination (MDS) of glioblastoma is rare, although its incidence might have been underestimated. MDS of glioblastoma has a fatal course. Thus, rapid and precise diagnosis of MDS is important for further palliative treatment. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504760PMC
April 2019
5 Reads

von Willebrand Factor Gene Expression in Primary Lower Grade Glioma: Mutually Co-Occurring Mutations in von Willebrand Factor, ATRX, and TP53.

Brain Tumor Res Treat 2019 Apr;7(1):33-38

Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: Venous thromboembolism is a common complication in patients with glioma. The clotting factor von Willebrand factor (VWF) is a highly adhesive procoagulant molecule that mediates platelet adhesion to endothelial and subendothelial surfaces. In the current analysis, we examined The Cancer Genome Atlas (TCGA) data to assess the VWF gene in patients with lower grade gliomas. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504758PMC
April 2019
7 Reads

Bacoside A Induced Sub-G0 Arrest and Early Apoptosis in Human Glioblastoma Cell Line U-87 MG through Notch Signaling Pathway.

Brain Tumor Res Treat 2019 Apr;7(1):25-32

Department of Biotechnology, Dayananda Sagar College of Engineering, Bangalore, India.

Background: Glioblastoma multiforme (GBM) is a highly malignant brain tumor with a worst prognosis of less than one year despite advance treatment facilities. Among various signaling pathway genes displaying genetic modifications, aberrant expression of Notch pathway genes is frequent in GBM offering novel therapeutic targets. Herbal extracts having anticancer properties are used in adjuvant therapy that is safe and affordable as compared to chemotherapeutics. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2019.
Publisher Site
http://dx.doi.org/10.14791/btrt.2019.7.e21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504756PMC
April 2019
16 Reads

Anti-Migration and Anti-Invasion Effects of Curcumin via Suppression of Fascin Expression in Glioblastoma Cells.

Brain Tumor Res Treat 2019 Apr;7(1):16-24

Department of Neurosurgery, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: The natural compound curcumin was known to inhibit migration and invasion of glioblastoma (GBM) cells. Fascin, a kind of actin-binding proteins, is correlated with migration and invasion of GBM cells. The purpose of this study was to investigate anti-migration and anti-invasion effects of curcumin via suppression of fascin expression in GBM cells. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504753PMC
April 2019
2 Reads

Utilization of the Nasoseptal Flap for Repair of Cerebrospinal Fluid Leak after Endoscopic Endonasal Approach for Resection of Pituitary Tumors.

Brain Tumor Res Treat 2019 Apr;7(1):10-15

Department of Neurosurgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: One of the most frequent complications after endoscopic endonasal approach (EEA) for resection of pituitary tumors is cerebrospinal fluid (CSF) leaks. With the introduction of the pedicled nasoseptal flap, the reconstruction of the skull base has improved significantly resulting in a decrease in the occurrence of persistent CSF leaks. We present our experience utilizing the pedicled nasoseptal flap technique after EEA for reconstruction of the skull base in cases where CSF leak was detected. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504757PMC
April 2019
7 Reads

The Korean Society for Neuro-Oncology (KSNO) Guideline for Glioblastomas: Version 2018.01.

Brain Tumor Res Treat 2019 Apr;7(1):1-9

Department of Neurosurgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.

Background: There has been no practical guidelines for the management of patients with central nervous system (CNS) tumors in Korea for many years. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, started to prepare guidelines for CNS tumors from February 2018.

Methods: The Working Group was composed of 35 multidisciplinary medical experts in Korea. Read More

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http://dx.doi.org/10.14791/btrt.2019.7.e25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6504754PMC
April 2019
10 Reads

Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide.

Brain Tumor Res Treat 2018 Oct;6(2):101-104

Department of Neurosurgery, Brain Tumor Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Pheochromocytoma (PCC) is a neuroendocrine tumor that mainly arises from the medulla of the adrenal gland. Some PCCs become malignant and metastasize to other organs. For example, it typically involves skeletal system, liver, lung, and regional lymph nodes. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212688PMC
October 2018
20 Reads

Metaplastic Meningioma Overspreading the Cerebral Convexity.

Brain Tumor Res Treat 2018 Oct;6(2):97-100

Department of Pathology, Ilsan Paik Hospital, College of Medicine, Inje University, Goyang, Korea.

Meningioma is relatively common, benign, and extra-axial tumor accounting for about 20% of primary brain and spinal cord tumors. The World Health Organization (WHO) classified these tumors into Grade I (benign), Grade II (atypical), and Grade III (anaplastic) meningioma. Grade I meningioma which is slowly growing tumor and have some rare subtypes. Read More

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http://dx.doi.org/10.14791/btrt.2018.6.e17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212693PMC
October 2018
17 Reads

Brain Abscess Showing a Lack of Restricted Diffusion and Successfully Treated with Linezolid.

Brain Tumor Res Treat 2018 Oct;6(2):92-96

Department of Neurosurgery, Eulji University, Nowon Eulji Medical Center, Seoul, Korea.

A 59-year-old patient with a history of hepatocellular carcinoma presented with decreased consciousness and left hemiparesis. A rim-enhanced mass lesion without diffusion restriction was observed in contrast-enhanced MRI including diffusion-weighted imaging. Based on these findings, metastatic brain tumor was suspected. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212685PMC
October 2018
35 Reads

Secondary Aneurysmal Bone Cyst in a Craniofacial Fibrous Dysplasia: Case Report.

Brain Tumor Res Treat 2018 Oct;6(2):86-91

Department of Neurosurgery, Konkuk University Medical Center, Seoul, Korea.

Aneurysmal bone cyst (ABC) is a rare non-neoplastic bone lesion that involves mostly the long bones and vertebrae and may occur very rarely in the craniofacial bones. ABCs may occur as secondary bony pathologies in association with various benign and malignant bone tumors and with fibrous dysplasia (FD). FD is a common non-neoplastic bony pathology mostly affecting craniofacial bones. Read More

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http://dx.doi.org/10.14791/btrt.2018.6.e15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212691PMC
October 2018
9 Reads

Giant Sellar Xanthogranuloma after Surgical Treatment of Symptomatic Rathke's Cleft Cyst.

Brain Tumor Res Treat 2018 Oct;6(2):82-85

Department of Pathology, Kosin University Gospel Hospital, Busan, Korea.

Extremely massive sellar xanthogranuloma (XG) are rare, and the surgical outcome and prognosis are not well known. XG remain unknown whether they are derived from Rathke's cleft cysts (RCCs) or craniopharyngiomas (CPs) following extensive inflammation and metaplasia, to the point that no epithelium is readily identifiable. These lesions usually tend to occur in younger patients (mean 28. Read More

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http://dx.doi.org/10.14791/btrt.2018.6.e10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212686PMC
October 2018
17 Reads

Gliosarcoma of Cerebello-Pontine Angle: A Case Report and Review of the Literature.

Brain Tumor Res Treat 2018 Oct;6(2):78-81

Department of Neurosurgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

Gliosarcoma (GS), known as variant of glioblastoma multiforme, is aggressive and very rare primary central nervous system malignant neoplasm. They are usually located in the supratentorial area with possible direct dural invasion or only reactive dural thickening. However, in this case, GS was located in lateral side of left posterior cranial fossa. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212687PMC
October 2018
2 Reads

Pineal and Suprasellar Germinoma Cooccurence with Vertebra Plana: A Case Report.

Brain Tumor Res Treat 2018 Oct;6(2):73-77

Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.

Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212690PMC
October 2018
15 Reads

Arachnoid Granulations Mimicking Multiple Osteolytic Bone Lesions in the Occipital Bone.

Brain Tumor Res Treat 2018 Oct;6(2):68-72

Department of Neurosurgery, Kyungpook National University School of Medicine, Kyungpook National University Hospital, Daegu, Korea.

We report a rare case of arachnoid granulations mimicking multiple osteolytic bone lesions. A 66-year-old woman was admitted to a local clinic for a regular checkup. Upon admission, brain CT showed multiple osteolytic lesions in the occipital bone. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212694PMC
October 2018
30 Reads

Surgical Outcomes of Thalamic Tumors in Children: The Importance of Diffusion Tensor Imaging, Neuro-Navigation and Intraoperative Neurophysiological Monitoring.

Brain Tumor Res Treat 2018 Oct;6(2):60-67

Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Background: Recently, modern technology such as diffusion tensor imaging (DTI), neuro-navigation and intraoperative neurophysiological monitoring (IOM) have been actively adopted for the treatment of thalamic tumors. We evaluated surgical outcomes and efficacy of the aforementioned technologies for the treatment of pediatric thalamic tumors.

Methods: We retrospectively reviewed clinical data from 37 children with thalamic tumors between 2004 and 2017. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
Publisher Site
http://dx.doi.org/10.14791/btrt.2018.6.e14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212692PMC
October 2018
18 Reads

A Retrospective Analysis of the Clinical Outcomes of Leptomeningeal Metastasis in Patients with Solid Tumors.

Brain Tumor Res Treat 2018 Oct;6(2):54-59

Department of Internal Medicine, Kosin University Gaspel Hospital, Busan, Korea.

Background: Leptomeningeal metastasis (LM) is an uncommon, but devastating complication of advanced cancer and has no standard treatment. Herein, we analyzed the clinical characteristics and outcomes of patients with solid tumors who were diagnosed with LM.

Methods: Between January 2007 and December 2017, we retrospectively analyzed the medical records of patients with solid tumors who were diagnosed with LM. Read More

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http://dx.doi.org/10.14791/btrt.2018.6.e12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212684PMC
October 2018
10 Reads