1,583 results match your criteria Brain and behavior[Journal]


Diagnostic accuracy of cognitive screening tools under different neuropsychological definitions for poststroke cognitive impairment.

Brain Behav 2020 Jul 3:e01671. Epub 2020 Jul 3.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Objectives: The accuracy of cognitive screening tools to detect poststroke cognitive impairment (PSCI) was investigated using various neuropsychological definitions.

Methods: Hospital-based stroke patients underwent a comprehensive neuropsychological assessment. The rate of PSCI was estimated using thresholds of 1, 1. Read More

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http://dx.doi.org/10.1002/brb3.1671DOI Listing

Transient effects of multi-infusion ketamine augmentation on treatment-resistant depressive symptoms in patients with treatment-resistant bipolar depression - An open-label three-week pilot study.

Brain Behav 2020 Jul 3:e01674. Epub 2020 Jul 3.

Department of Psychiatry Wenzhou Seventh People's Hospital, Wenzhou, China.

Introduction: While the psychiatric benefits of ketamine have been verified through clinical trials, there is limited information about ketamine augmentation in patients with treatment-resistant bipolar depression (TRBPD). Hence, in the present study, we investigate the therapeutic efficacy and functional brain alterations associated with multi-infusion ketamine augmentation in patients with TRBPD.

Methods: The present three-week study included 38 patients with TRBPD, all of whom received a series of nine ketamine injections over the study period. Read More

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http://dx.doi.org/10.1002/brb3.1674DOI Listing

Reproducibility of graph measures at the subject level using resting-state fMRI.

Brain Behav 2020 Jul 2:e01705. Epub 2020 Jul 2.

Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Leuven, Belgium.

Introduction: Graph metrics have been proposed as potential biomarkers for diagnosis in clinical work. However, before it can be applied in a clinical setting, their reproducibility should be evaluated.

Methods: This study systematically investigated the effect of two denoising pipelines and different whole-brain network constructions on reproducibility of subject-specific graph measures. Read More

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http://dx.doi.org/10.1002/brb3.1705DOI Listing

Fetal eye movements in response to a visual stimulus.

Brain Behav 2020 Jul 1:e01676. Epub 2020 Jul 1.

Department of Psychology, Lancaster University, Lancaster, UK.

Introduction: In 2D ultrasound, the lens of the fetal eye can be distinguished as white circles within the hypoechoic eyeball, and eye movements can be visualized from about 15 weeks' gestation. It has been shown that from 31 weeks gestational age the fetal sensory system is capable of directed vision if enough light is available.

Methods: We have developed a light source for delivering visual stimuli to be seen by the fetal eye, using laser dot diodes emitting at 650 nm. Read More

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http://dx.doi.org/10.1002/brb3.1676DOI Listing

Effects of mirror neuron system-based training on rehabilitation of stroke patients.

Brain Behav 2020 Jul 1:e01729. Epub 2020 Jul 1.

School of Rehabilitation Science and Institute of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Objective: To investigate the clinical effects of the mirror neuron system (MNS)-based training on upper extremity motor function and cognitive function in stroke patients.

Methods: Sixty stroke patients (time from stroke onset 3-9 months) with upper extremity paresis (Brunnstrom stage II-IV) and cognitive impairment (MoCA score ≥ 15) were enrolled in this study. Patients were randomly allocated into MNS treatment group (N = 30) and control group (N = 30). Read More

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http://dx.doi.org/10.1002/brb3.1729DOI Listing

Effects of environmental tobacco smoke exposure on brain functioning in never-smoking adolescents.

Brain Behav 2020 Jul 1:e01619. Epub 2020 Jul 1.

Behavioural Science Institute, Radboud University, Nijmegen, The Netherlands.

Introduction: Brain functioning, as indexed by event-related potentials (ERPs) representing smoking cue reactivity, inhibitory control, and reward processing, has been found to be compromised in smokers. However, whether environmental tobacco smoke (ETS) exposure in never smokers results in similar brain changes is unknown. This question is particularly relevant during adolescence, given ongoing brain maturation and a high risk of smoking initiation. Read More

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http://dx.doi.org/10.1002/brb3.1619DOI Listing

Identifying interactive biological pathways associated with reading disability.

Brain Behav 2020 Jun 28:e01735. Epub 2020 Jun 28.

School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA.

Introduction: Past research has suggested that reading disability is a complex disorder involving genetic and environment contributions, as well as gene-gene and gene-environment interaction, but to date little is known about the underlying mechanisms.

Method: Using the Avon Longitudinal Study of Parents and Children, we assessed the contributions of genetic, demographic, and environmental variables on case-control status using machine learning. We investigated the functional interactions between genes using pathway and network analysis. Read More

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http://dx.doi.org/10.1002/brb3.1735DOI Listing

High-frequency transcranial magnetic stimulation protects APP/PS1 mice against Alzheimer's disease progress by reducing APOE and enhancing autophagy.

Brain Behav 2020 Jun 26:e01740. Epub 2020 Jun 26.

Department of Neurology, Laboratory of Neurological Diseases, Reproductive Medicine Centre, Changzhou No. 2 People's Hospital, The Affiliated Hospital of Nanjing Medical University, Changzhou, China.

Introduction: The repetitive transcranial magnetic stimulation (rTMS) has clinically wide application prospect of psychiatry and neuroscience, for its painless, noninvasive, and high efficiency. So far, rTMS has been used in the treatment of Alzheimer's disease (AD) but the underlying mechanism is not clear.

Methods And Results: The APP/PS1 mice at 3-month-old were treated by 5 Hz high-frequency (HF) rTMS for two weeks. Read More

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http://dx.doi.org/10.1002/brb3.1740DOI Listing

Robot-assisted therapy for upper-limb rehabilitation in subacute stroke patients: A systematic review and meta-analysis.

Brain Behav 2020 Jun 26:e01742. Epub 2020 Jun 26.

The Nethersole School of Nursing, The Chinese University of Hong Kond, New Territories, Hong Kong.

Background: Stroke survivors often experience upper-limb motor deficits and achieve limited motor recovery within six months after the onset of stroke. We aimed to systematically review the effects of robot-assisted therapy (RT) in comparison to usual care on the functional and health outcomes of subacute stroke survivors.

Methods: Randomized controlled trials (RCTs) published between January 1, 2000 and December 31, 2019 were identified from six electronic databases. Read More

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http://dx.doi.org/10.1002/brb3.1742DOI Listing

Relationship between insecure attachment and physical symptom severity is mediated by sensory sensitivity.

Brain Behav 2020 Jun 26:e01717. Epub 2020 Jun 26.

Department of Psychiatry, Mount Sinai Hospital, Toronto, ON, Canada.

Objective: Various models have been used to explain somatization, including attachment theory, which describes how formative experiences influence perceptions of vulnerability and threat. Although attachment insecurity is associated with greater physical symptoms, the mechanisms by which attachment insecurity influences the experience of physical symptoms are not clear. Sensory processing sensitivity (SPS) describes a low threshold to responding to stimuli and high emotional reactivity. Read More

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http://dx.doi.org/10.1002/brb3.1717DOI Listing

A qualitative exploration of the sociology of poststroke visual impairments and the associated health inequalities.

Brain Behav 2020 Jun 26:e01738. Epub 2020 Jun 26.

Department of Health Services Research, University of Liverpool, Liverpool, UK.

Introduction: Inequalities have been found to exist within the visually impaired stroke population on an individual level, in relation to demographic differences, unequal access to vision services, transport, employment, and financial repercussions. The long-term impact of living with poststroke visual impairments must be explored, in order to identify complications accessing NHS services and to inform possible changes to service planning and delivery in order to tackle such complications.

Aim: To explore the extent of health inequalities within visually impaired stroke survivors in the northwest of England and discuss potential solutions to these. Read More

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http://dx.doi.org/10.1002/brb3.1738DOI Listing

Memory deficits in Sprague Dawley rats with spontaneous ventriculomegaly.

Brain Behav 2020 Jun 25:e01711. Epub 2020 Jun 25.

Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus UNAM-Juriquilla, Queretaro, Mexico.

Introduction: Spontaneous ventriculomegaly has been observed in rats that were presumed normal. Because the external phenotype of these animals is unremarkable, they can be inadvertently included in behavioral experiments, despite the considerable enlargement of the ventricular system, reduced cortical thickness, and hippocampal atrophy upon imaging. Given the role of such structures in memory consolidation, we evaluated long-term memory retention while decision making in rats with spontaneous ventriculomegaly. Read More

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http://dx.doi.org/10.1002/brb3.1711DOI Listing

Investigating the relationship between interleukin-6 serum levels and outcome in acute ischemic CVA.

Brain Behav 2020 Jun 25:e01668. Epub 2020 Jun 25.

Urmia University of Medical Sciences, Urmia, Iran.

Introduction: Interleukin-6 (IL-6) is among the inflammatory mediators exhibiting elevated levels in ischemic stroke (IS) patients. The present study set out to evaluate the relationship between serum levels of interleukin-6 with long-term and at-hospital outcomes of acute ischemic stroke in patients hospitalized at Imam Khomeini Hospital, Urmia, Iran, from 2017 to 2018.

Method And Materials: This cross-sectional descriptive study enrolled 29 and 31 acute stroke patients for long-term and at-hospital observation, respectively. Read More

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http://dx.doi.org/10.1002/brb3.1668DOI Listing

Neuro-Sjögren: Uncommon or underestimated problem?

Brain Behav 2020 Jun 25:e01665. Epub 2020 Jun 25.

Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland.

Objectives: Sjögren's syndrome (SS) is a chronic inflammatory disease with an autoimmune background with possible complications from peripheral (PNS) and central nervous system (CNS). The aim of this study was to assess the prevalence and to describe the phenotype of peripheral neuropathies in patients with SS.

Materials & Methods: We studied fifty patients with primary Sjögren's syndrome for peripheral nervous system involvement. Read More

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http://dx.doi.org/10.1002/brb3.1665DOI Listing

Altered somatosensory evoked potentials associated with improved reaction time in a simple sensorimotor response task following repetitive practice.

Brain Behav 2020 Jun 25:e01624. Epub 2020 Jun 25.

Department of Physical Therapy, School of Health Science, Sapporo Medical University, Sapporo, Japan.

Introduction: Repetitive practice of sensorimotor tasks is widely used for neurorehabilitation; however, it is unknown how practice alters sensory processing (e.g., recognition, discrimination, and attentional allocation) and associated cognitive processing, such as decision-making. Read More

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http://dx.doi.org/10.1002/brb3.1624DOI Listing

Differences of connectivity between ESRD patients with PD and HD.

Brain Behav 2020 Jun 24:e01708. Epub 2020 Jun 24.

Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.

Objectives: The aim of this study was to investigate alterations in structural and functional brain connectivity between patients with end-stage renal disease (ESRD) who were undergoing peritoneal dialysis (PD) and hemodialysis (HD).

Methods: We enrolled 40 patients with ESRD who were undergoing PD (20 patients) and HD (20 patients). We also enrolled healthy participants as a control group. Read More

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http://dx.doi.org/10.1002/brb3.1708DOI Listing

Mental health status of the general population, healthcare professionals, and university students during 2019 coronavirus disease outbreak in Jordan: A cross-sectional study.

Brain Behav 2020 Jun 24:e01730. Epub 2020 Jun 24.

Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Saudi Arabia.

Background: The emergence of COVID-19 global pandemic coupled with high transmission rate and mortality has created an unprecedented state of emergency worldwide. This global situation may have a negative impact on the psychological well-being of individuals which in turn impacts individuals' performance. This study aims to explore the prevalence of depression and anxiety among the GP, HCPs, and USs during COVID-19 outbreak, and to identify key population(s) who might need psychological intervention. Read More

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http://dx.doi.org/10.1002/brb3.1730DOI Listing

The maturation of the P1m component in response to voice from infancy to 3 years of age: A longitudinal study in young children.

Brain Behav 2020 Jun 23:e01706. Epub 2020 Jun 23.

Research Center for Child Mental Development, Kanazawa University, Kanazawa, Japan.

Introduction: In the early development of human infants and toddlers, remarkable changes in brain cortical function for auditory processing have been reported. Knowing the maturational trajectory of auditory cortex responses to human voice in typically developing young children is crucial for identifying voice processing abnormalities in children at risk for neurodevelopmental disorders and language impairment. An early prominent positive component in the cerebral auditory response in newborns has been reported in previous electroencephalography and magnetoencephalography (MEG) studies. Read More

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http://dx.doi.org/10.1002/brb3.1706DOI Listing

Proteins of the Lectin Pathway of complement activation at the site of injury in subarachnoid hemorrhage compared with peripheral blood.

Brain Behav 2020 Jun 21:e01728. Epub 2020 Jun 21.

Department of Biomedicine, Aarhus University, Aarhus, Denmark.

Background: A subarachnoid hemorrhage (SAH) is a debilitating stroke. Activation of the lectin pathway (LP) of the complement system in SAH patients could worsen the prognosis; however, conflicting results have been reported. This potentially reflects that pathological changes at the site of injury are not reflected in peripheral blood. Read More

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http://dx.doi.org/10.1002/brb3.1728DOI Listing

The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography.

Brain Behav 2020 Jun 20:e01646. Epub 2020 Jun 20.

Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY, USA.

Introduction: Novel environment stimulation is thought to have an important role in cognitive development and has been shown to encourage exploratory behavior in rats. However, psychopathology or perceived danger or stress can impede this exploratory drive. The balance between brain circuits controlling the exploratory drive elicited by a novel environment, and the avoidance response to stressors, is not well understood. Read More

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http://dx.doi.org/10.1002/brb3.1646DOI Listing

Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study.

Brain Behav 2020 Jun 18:e01725. Epub 2020 Jun 18.

Department of MRI, Shaanxi Provincial People's Hospital, Xi'an, China.

Objective: To explore the neural mechanisms of brain impairment in type 2 diabetes mellitus (T2DM), abnormal changes to the functional connections between brain regions in the resting state were investigated based on a meta-analysis.

Methods: Resting-state functional magnetic resonance imaging (fMRI) and neuropsychological assessment were performed on 38 patients with T2DM and 33 healthy controls (HCs). Functional connectivity between regions based on a meta-analysis and other voxels in the brain was calculated and compared between the two groups using a two-sample t test. Read More

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http://dx.doi.org/10.1002/brb3.1725DOI Listing

Neural substrates underlying progressive micrographia in Parkinson's disease.

Brain Behav 2020 Jun 18:e01669. Epub 2020 Jun 18.

Department of Behavioural Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

Introduction: The neural substrates associated with the development of micrographia remain unknown. We aimed to elucidate the neural substrates underlying micrographia in Parkinson's disease (PD) patients.

Methods: Forty PD patients and 20 healthy controls underwent handwriting tests that involved free writing and copying. Read More

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http://dx.doi.org/10.1002/brb3.1669DOI Listing

Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract-based spatial statistics study.

Brain Behav 2020 Jun 17:e01720. Epub 2020 Jun 17.

Department of Ophthalmology, Jiangxi Province Clinical Ophthalmology Institute, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Background: Visual deprivation can lead to abnormal and plastic changes in the brain's visual system and other systems. Although the secondary changes of gray matter in patients have been well studied, the study of white matter is rare. In fact, subtle changes in white matter may be revealed by diffusion tensor imaging, and tract-based spatial statistics can be used to analyze DTI image data. Read More

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http://dx.doi.org/10.1002/brb3.1720DOI Listing

Functional network activity during errorless and trial-and-error color-name association learning.

Brain Behav 2020 Jun 18:e01723. Epub 2020 Jun 18.

Department of Rehabilitation Science, Graduate School of Health Sciences Discipline, Life and Medical Sciences Area, Kobe University, Kobe, Japan.

Introduction: In cognitive rehabilitation, errorless (EL) and trial-and-error (T&E) learning are well-known methods, but their neural mechanisms are not well known. In this study, we investigated functional magnetic resonance imaging data for healthy adults during EL and T&E learning.

Methods: Participants memorized color-name associations in both methods using Japanese traditional colors which were unfamiliar to study participants. Read More

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http://dx.doi.org/10.1002/brb3.1723DOI Listing

The effect of pentadecapeptide BPC 157 on hippocampal ischemia/reperfusion injuries in rats.

Brain Behav 2020 Jun 18:e01726. Epub 2020 Jun 18.

Department of Pharmacology, Medical School, University of Zagreb, Zagreb, Croatia.

Background And Purpose: We focused on the, yet undescribed, therapy effect of the stable gastric pentadecapeptide BPC 157 in hippocampal ischemia/reperfusion injuries, after bilateral clamping of the common carotid arteries in rats. The background is the proven therapy effect of BPC 157 in ischemia/reperfusion injuries in different tissues. Furthermore, there is the subsequent oxidative stress counteraction, particularly when given during reperfusion. Read More

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http://dx.doi.org/10.1002/brb3.1726DOI Listing

Performance of healthy persons under pain in different cognitive load tasks: An event-related potential study on experimental pain individuals.

Brain Behav 2020 Jun 18:e01713. Epub 2020 Jun 18.

Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Objective: This study aims to determine how brain activities underlying task with different cognitive load would be modulated by the painful state using electroencephalography.

Methods: The pain state was established by spraying capsaicin on subjects' left inner forearm. A total of 20 experimental pain subjects and 20 matched nonpain controls underwent cognitive tasks with electroencephalogram recording. Read More

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http://dx.doi.org/10.1002/brb3.1713DOI Listing

Prognostic factors in children with head and neck rhabdomyosarcoma: A 12-year retrospective study.

Brain Behav 2020 Jun 16:e01697. Epub 2020 Jun 16.

Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Introduction: To identify possible prognostic factors in children with head and neck rhabdomyosarcoma (RMS).

Methods: A total of 98 patients with head and neck RMS were enrolled in this retrospective study from February 2005 to September 2017. Prognostic factors were evaluated by univariate and multivariate analysis using Cox's proportional hazards model. Read More

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http://dx.doi.org/10.1002/brb3.1697DOI Listing

Effective connectivity during autobiographical memory search.

Brain Behav 2020 Jun 15:e01719. Epub 2020 Jun 15.

Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology (NICT), Osaka, Japan.

Introduction: We used dynamic causal modeling (DCM) to examine effective connectivity during cued autobiographical memory (AM) search in a left-hemispheric network consisting of six major regions within the large network of brain regions recruited during memory retrieval processes.

Methods: Functional MRI data were acquired while participants were shown verbal cues describing common life events and requested to search for a personal memory associated with the cue. We examined directed couplings between the ventromedial (vmPFC), dorsomedial (dmPFC), and dorsolateral prefrontal cortices (dlPFC), hippocampus, angular gyrus, and the posterior midline cortex (RSC/PCC/Prec). Read More

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http://dx.doi.org/10.1002/brb3.1719DOI Listing

Altered gut bacterial-fungal interkingdom networks in patients with current depressive episode.

Brain Behav 2020 Jun 12:e01677. Epub 2020 Jun 12.

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Introduction: Bacterial dysbiosis has been described in patients with current depressive episode (CDE); however, the fungal composition in the gut has not been investigated in these patients.

Methods: Here, we characterized the fungal gut mycobiota in patients with CDE. We systematically characterized the microbiota and mycobiota in fecal samples obtained from 24 patients with CDE and 16 healthy controls (HC) using 16S rRNA gene- and ITS1-based DNA sequencing, respectively. Read More

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http://dx.doi.org/10.1002/brb3.1677DOI Listing

Expression of hypoxia-inducible factor 1α, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors.

Brain Behav 2020 Jun 12:e01718. Epub 2020 Jun 12.

Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: It has been indicated that abnormal glucose metabolism mediated by hypoxia-inducible factor 1α (HIF-1α) played an essential role in the development of solid tumor. However, there were rare studies about the role of them in primary central nervous system lymphoma (PCNSL).

Objective: To investigate the protein levels of HIF-1α, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) in PCNSL and whether their levels are associated with prognostic factors. Read More

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http://dx.doi.org/10.1002/brb3.1718DOI Listing

Effects of oxiracetam combined with ginkgo biloba extract in the treatment of acute intracerebral hemorrhage: A clinical study.

Brain Behav 2020 Jun 12:e01661. Epub 2020 Jun 12.

Department of Neurology, Linyi Central Hospital, Linyi, China.

Purpose: The present clinical study was conducted to investigate the effect of oxiracetam combined with ginkgo biloba extract in treating patients with acute intracerebral hemorrhage.

Methods: Ninety-eight patients with acute cerebral hemorrhage admitted to our hospital were divided into three groups. The differences of brain edema and cerebral hemorrhage were compared between the three groups after 1 and 2 weeks of treatment, and the recovery of neurological function, serum inflammatory factors, AQP-4, MMP-9, cognitive function, activities of daily living, and adverse reactions were compared between the three groups after 2 weeks of treatment. Read More

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http://dx.doi.org/10.1002/brb3.1661DOI Listing

Blood pressure after follow-up in a stroke prevention clinic.

Brain Behav 2020 Jun 12:e01667. Epub 2020 Jun 12.

Department of Neurology, Rigshospitalet, Copenhagen, Denmark.

Objectives: In Denmark, 25% of hospital admissions with stroke are recurrent strokes. With thrombolytic treatment, more patients survive with only minor disability. This promising development should be followed up by intensive secondary prevention. Read More

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http://dx.doi.org/10.1002/brb3.1667DOI Listing

Functional and cognitive capacity differ in dystonic motor subtypes when compared to choreatic and hypokinetic-rigid motor subtypes in Huntington's disease.

Brain Behav 2020 Jun 12:e01704. Epub 2020 Jun 12.

Department of Neurology, St. Josef-Hospital, Bochum, Germany.

Background: Motor phenotypes in Huntington's disease vary manifold. Phenotype classification is essential to adapt treatment. The aim of this study was to classify a dystonic subtype closer. Read More

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http://dx.doi.org/10.1002/brb3.1704DOI Listing

Sex-dependent alterations of dopamine receptor and glucose transporter density in rat hypothalamus under long-term clozapine and haloperidol medication.

Brain Behav 2020 Jun 11:e01694. Epub 2020 Jun 11.

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

Objective: Sex-dependent disturbances of peripheral glucose metabolism are known complications of antipsychotic drug treatment. The influence of long-term clozapine and haloperidol medication on hypothalamus, maintaining aspects of internal body homeostasis, has not yet been completely clarified.

Methods: After puberty, male and female Sprague Dawley rats were fed orally with ground pellets containing haloperidol (1 mg/kgBW/day) or clozapine (20 mg/kgBW/day) for 12 weeks. Read More

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http://dx.doi.org/10.1002/brb3.1694DOI Listing

bFGF promotes neurological recovery from neonatal hypoxic-ischemic encephalopathy by IL-1β signaling pathway-mediated axon regeneration.

Brain Behav 2020 Jun 11:e01696. Epub 2020 Jun 11.

National Traditional Chinese Medicine Clinical Research Base and Western Medicine Translational Medicine Research Center, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.

Introduction: Neonatal hypoxia-ischemic brain damage (HIBD) can lead to serious neuron damage and dysfunction, causing a significant worldwide health problem. bFGF as a protective reagent promotes neuron repair under hypoxia/ischemia (HI). However, how bFGF and downstream molecules were regulated in HI remains elusive. Read More

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http://dx.doi.org/10.1002/brb3.1696DOI Listing

Parkinson's disease or atypical parkinsonism? The importance of acoustic voice analysis in differential diagnosis of speech disorders.

Brain Behav 2020 Jun 11:e01700. Epub 2020 Jun 11.

Department of Neurology, The Faculty of Health Sciences, Medical University of Warsaw, Warsaw, Poland.

Introduction: Speech disorder is a common clinical manifestation in patients with Parkinson's disease and atypical parkinsonian syndromes and tends to occur before the onset of the axial parkinsonian symptoms. Due to parkinsonian features that overlap those of Parkinson's disease, the differentiation of voice and a speech disorder is a challenge for clinicians primarily in the early stage of the disease.

Methods: Speech samples were obtained from 116 subjects including 30 cases of Parkinson's disease, 30 cases of progressive supranuclear palsy, 30 cases of multiple system atrophy, and control group consisted of 26 subjects. Read More

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http://dx.doi.org/10.1002/brb3.1700DOI Listing

Multi-voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity.

Brain Behav 2020 Jun 11:e01707. Epub 2020 Jun 11.

Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.

Introduction: Resting state functional magnetic resonance imaging (rsfMRI) studies demonstrate that individuals with posttraumatic stress disorder (PTSD) exhibit atypical functional connectivity (FC) between the amygdala, involved in the generation of emotion, and regions responsible for emotional appraisal (e.g., insula, orbitofrontal cortex [OFC]) and regulation (prefrontal cortex [PFC], anterior cingulate cortex). Read More

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http://dx.doi.org/10.1002/brb3.1707DOI Listing

Gepants for abortive treatment of migraine: A network meta-analysis.

Brain Behav 2020 Jun 11:e01701. Epub 2020 Jun 11.

Department of Geriatric Medicine and Neurology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Objectives: To evaluate and compare the efficacy and safety of gepants for abortive treatment of migraine by network meta-analysis.

Materials & Methods: Publications, which were randomized controlled trials (RCTs) about gepants for abortive treatment of migraine, were acquired from Pubmed and Cochrane Library. The literatures screening and quality assessment followed the Cochrane handbook. Read More

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http://dx.doi.org/10.1002/brb3.1701DOI Listing

Left ventricular ejection fraction as an independent predictor of poor outcome in acute intracerebral hemorrhage.

Brain Behav 2020 Jun 9:e01643. Epub 2020 Jun 9.

Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Introduction: Few studies of the effect of cardiac abnormalities on acute intracerebral hemorrhage (ICH) outcomes have been published. We sought to determine whether the left ventricular ejection fraction (LVEF) is associated with the functional outcome and mortality of acute ICH patients.

Methods: We conducted a retrospective study on 364 acute ICH patients from January to December 2016. Read More

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http://dx.doi.org/10.1002/brb3.1643DOI Listing

Effectiveness of Natural Frequency Technology on cognition, sleep, and mood of adults with high perceived stress: A randomized, double-blind, placebo-controlled crossover study.

Brain Behav 2020 Jun 8:e01712. Epub 2020 Jun 8.

Center for Health and Human Performance, Jacksonville University, Jacksonville, FL, USA.

Introduction: NexQuest Natural Frequency Technology (NFT ), intended to enhance biological function using naturally occurring frequencies, may be a nonpharmacological intervention to improve stress and health. The study purpose was to determine the effectiveness of NFT for improving stress, sleep quality, mood, and cognition in adults.

Methods: Using a double-blind placebo-controlled crossover design, participants with high perceived stress (N = 42, M age = 43. Read More

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http://dx.doi.org/10.1002/brb3.1712DOI Listing

Altered activation in sensorimotor network after applying rTMS over the primary motor cortex at different frequencies.

Brain Behav 2020 Jun 7:e01670. Epub 2020 Jun 7.

Institute of Psychological Sciences, Hangzhou Normal University, Hangzhou, China.

Introduction: Repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) can modulate brain activity both in the stimulated site and remote brain areas of the sensorimotor network. However, the modulatory effects of rTMS at different frequencies remain unclear. Here, we employed finger-tapping task-based fMRI to investigate alterations in activation of the sensorimotor network after the application of rTMS over the left M1 at different frequencies. Read More

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http://dx.doi.org/10.1002/brb3.1670DOI Listing

"Seat of the soul"? The structure and function of the pineal gland in women with alleged spirit possession-Results of two experimental studies.

Brain Behav 2020 Jun 7:e01693. Epub 2020 Jun 7.

School of Medicine, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Background: Cultural traditions attribute to pineal gland an important role for spiritual experiences. Mediumship and spirit possession are cultural phenomena found worldwide which have been described as having dissociative and psychotic-like characteristics, but with nonpathological aspects. A sympathetic activation pattern in response to spirit possession has been reported in some studies, but empirical data on pineal gland is scarce in this context. Read More

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http://dx.doi.org/10.1002/brb3.1693DOI Listing

Trousseau syndrome with intrahepatic cholangiocarcinoma that could be removed radically after endovascular treatment: Report of a case.

Brain Behav 2020 Jun 7:e01660. Epub 2020 Jun 7.

Department of Neurology, Kumamoto Rosai Hospital, Kumamoto, Japan.

Background: Trousseau syndrome is a poor prognosis. We report a case of Trousseau syndrome treated by radical resection after endovascular treatment.

Case: A 59-year-old woman presented to our department reporting spontaneous dizziness and pain of the upper abdomen. Read More

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http://dx.doi.org/10.1002/brb3.1660DOI Listing

Dynamic visual cortical connectivity analysis based on functional magnetic resonance imaging.

Brain Behav 2020 Jun 7:e01698. Epub 2020 Jun 7.

Laboratory of Digital Image and Intelligent Computation, Shanghai Maritime University, Shanghai, China.

Background: Studies of brain functional connectivity (FC) and effective connectivity (EC) using the functional magnetic resonance imaging (fMRI) have advanced our understanding of functional organization on visual cortex of human brain. The current studies mainly focus on static or dynamic connectivity, while the relationships between them have not been well characterized especially for static EC (sEC) and dynamic EC (dEC), as well as the consistency characteristics of changing trend of dFCs and dECs, which is of great importance to reveal the neural information processing mechanism in visual cortex region.

Method: In this study, we explore these relationships among several subareas of human visual cortex (V1-V5) by calculating the connection intensity and information flow among them over time by sliding window method, which are defined by Pearson correlation coefficient and Granger causality analysis, respectively, in each window. Read More

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http://dx.doi.org/10.1002/brb3.1698DOI Listing

Dissociated modulations of multivoxel activation patterns in the ventral and dorsal visual pathways by the temporal dynamics of stimuli.

Brain Behav 2020 Jun 4:e01673. Epub 2020 Jun 4.

School of Psychology, South China Normal University, Guangzhou, China.

Introduction: Previous studies suggested temporal limitations of visual object identification in the ventral pathway. Moreover, multivoxel pattern analyses (MVPA) of fMRI activation have shown reliable encoding of various object categories including faces and tools in the ventral pathway. By contrast, the dorsal pathway is involved in reaching a target and grasping a tool, and quicker in processing the temporal dynamics of stimulus change. Read More

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http://dx.doi.org/10.1002/brb3.1673DOI Listing

Alzheimer's amyloid-β and tau protein accumulation is associated with decreased expression of the LDL receptor-associated protein in human brain tissue.

Brain Behav 2020 Jun 2:e01672. Epub 2020 Jun 2.

Neuroscience Research Australia, Randwick, Sydney, NSW, Australia.

Introduction: One of the major neuropathological features of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) protein in the brain. Evidence suggests that the low-density lipoprotein receptor-associated protein (RAP) binds strongly to Aβ and enhances its cellular uptake and that decreased RAP expression correlates with increased Aβ production in animal models of AD.

Methods: The current study examined whether RAP levels change in AD human brain tissue and whether they are related to the amount of AD pathology. Read More

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http://dx.doi.org/10.1002/brb3.1672DOI Listing

Clinical relevance of serum omentin-1 levels as a biomarker of prognosis in patients with acute cerebral infarction.

Authors:
Jingyi Yang Yan Gao

Brain Behav 2020 Jun 1:e01678. Epub 2020 Jun 1.

Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.

Background And Purpose: Previous studies have shown that adipocytokines are associated with atherosclerosis, diagnosis, and functional prognosis after ischemic stroke. However, few studies have investigated the relationship between omentin-1 and atherosclerotic acute cerebral infarction (ACI).

Methods: In this study, we investigated the association between serum omentin-1 levels at admission and severity, infarction volume, and functional prognosis of patients 90 days after atherosclerotic ACI. Read More

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http://dx.doi.org/10.1002/brb3.1678DOI Listing

Hypoxic preconditioning enhances the differentiation of bone marrow stromal cells into mature oligodendrocytes via the mTOR/HIF-1α/VEGF pathway in traumatic brain injury.

Brain Behav 2020 May 30:e01675. Epub 2020 May 30.

Department of Neurophysiology and Neuropharmacology, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, Nantong, China.

Objective: Traumatic brain injury (TBI) results not only in gray matter damage, but also in severe white matter injury (WMI). Previous findings support hypoxic preconditioning (HP) could augment the efficacy of bone marrow stromal cell (BMSC) transplantation in a TBI mouse model. However, whether HP-treated BMSCs (H-BMSCs) could overcome remyelination failure after WMI is unclear, and the molecular mechanisms remain to be explored. Read More

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http://dx.doi.org/10.1002/brb3.1675DOI Listing

Limb-shaking transient ischemic attack with facial muscles involuntary twitch successfully treated with internal carotid artery stenting.

Brain Behav 2020 May 30:e01679. Epub 2020 May 30.

Department of Neurology, Suqian First Hospital, Suqian, China.

Introduction: Limb-shaking transient ischemic attack (LS-TIA) is a clinical disease with severe carotid stenosis, which is characterized by unilateral rhythmic dance or tremor like involuntary movements of arms and/or legs, but facial muscles are usually unaffected.

Methods: Today, we report a 42-year-old man with transient ischemic attack who suffered from right limb shaking and right facial muscle twitching due to the obvious stenosis of left internal carotid artery (ICA). Written informed consent was obtained from participants according to the Declaration of Helsinki, and a local ethic committee approved the study. Read More

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http://dx.doi.org/10.1002/brb3.1679DOI Listing