1,179 results match your criteria Brain and behavior[Journal]


Emotion sensitivity and self-reported symptoms of generalized anxiety disorder across the lifespan: A population-based sample approach.

Brain Behav 2019 Apr 16:e01282. Epub 2019 Apr 16.

Institute for Technology in Psychiatry, McLean Hospital, Belmont, Massachusetts.

Background: Individuals with generalized anxiety disorder (GAD) symptoms show deficits in emotion processing, but results of prior studies have been conflicting, and little is known about developmental trajectories of emotion processing over time. We examined the association between GAD symptoms and sensitivity to recognizing emotional facial expressions (emotion sensitivity: ES) for three emotions (happiness, anger, fear) in a large, diverse, population-based sample. We hypothesized that higher anxiety scores would be associated with poorer performance, and expected that ES performance and anxiety scores would decline across the lifespan. Read More

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http://dx.doi.org/10.1002/brb3.1282DOI Listing

Interrupted transport by the emergency medical service in stroke/transitory ischemic attack: A consequence of changed treatment routines in prehospital emergency care.

Brain Behav 2019 Apr 13:e01266. Epub 2019 Apr 13.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Background: The discovery that not all patients who call for the emergency medical service (EMS) require transport to hospital has changed the structure of prehospital emergency care. Today, the EMS clinician at the scene already distinguishes patients with a time-critical condition such as stroke/transitory ischemic attack (TIA) from patients without. This highlights the importance of the early identification of stroke/TIA. Read More

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http://dx.doi.org/10.1002/brb3.1266DOI Listing

A clinical case-control comparison of epidermal innervation density in Rett syndrome.

Brain Behav 2019 Apr 13:e01285. Epub 2019 Apr 13.

Department of Neurology, Peripheral Nerve Laboratory, University of Minnesota, Minneapolis, MN.

Introduction: Rett syndrome (RTT), a rare neurodevelopmental disorder occurring primarily in females (1:10-15,000 female live births), is most often caused by loss-of-function mutations in the X-linked methyl-CpG-binding protein 2 gene (MECP2). Clinical observations and preclinical findings indicate apparent abnormal sensory and nociceptive function. There have been no direct investigations of epidermal sensory innervation in patients with RTT. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1285
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http://dx.doi.org/10.1002/brb3.1285DOI Listing
April 2019
3 Reads

Inferior parietal lobule and early visual areas support elicitation of individualized meanings during narrative listening.

Brain Behav 2019 Apr 11:e01288. Epub 2019 Apr 11.

Department of Psychology and Logopedics, Medical Faculty, University of Helsinki, Helsinki, Finland.

Introduction: When listening to a narrative, the verbal expressions translate into meanings and flow of mental imagery. However, the same narrative can be heard quite differently based on differences in listeners' previous experiences and knowledge. We capitalized on such differences to disclose brain regions that support transformation of narrative into individualized propositional meanings and associated mental imagery by analyzing brain activity associated with behaviorally assessed individual meanings elicited by a narrative. Read More

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http://dx.doi.org/10.1002/brb3.1288DOI Listing

Disruption of sleep architecture in Prevotella enterotype of patients with obstructive sleep apnea-hypopnea syndrome.

Brain Behav 2019 Apr 8:e01287. Epub 2019 Apr 8.

Department of Pulmonary and Critical Care Medicine, the Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Introduction: Intermittent hypoxia and sleep fragmentation are critical pathophysiological processes involved in obstructive sleep apnea-hypopnea syndrome (OSAHS). Those manifestations independently affect similar brain regions and contribute to OSAHS-related comorbidities that are known to be related to the host gut alteration microbiota. We hypothesized that gut microbiota disruption may cross talk the brain function via the microbiota-gut-brain axis. Read More

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http://dx.doi.org/10.1002/brb3.1287DOI Listing
April 2019
1 Read

A multidisciplinary approach to assess recovery of consciousness in a patient with moyamoya disease.

Brain Behav 2019 Apr 5:e01241. Epub 2019 Apr 5.

Neuroimaging Laboratory, IRCCS Centro Neurolesi "Bonino Pulejo", Messina, Italy.

Introduction: Moyamoya disease (MMD) meaning "hazy puff of smoke" in Japanese is a rare chronic cerebrovascular syndrome characterized by progressive stenosis and occlusion of the internal carotid arteries (ICAs) anterior cerebral arteries (ACAs), and middle cerebral arteries (MCAs).

Methods: Our moyamoya patient with severely impaired cognitive and motor functions underwent a specific motor and neuropsychological rehabilitative treatments to assess the recovery of consciousness.

Results: Results obtained showed an improvement of clinical and neuropsychological examination. Read More

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http://dx.doi.org/10.1002/brb3.1241DOI Listing
April 2019
1 Read

Effect of individual food preferences on oscillatory brain activity.

Brain Behav 2019 Apr 4:e01262. Epub 2019 Apr 4.

Department of Neurosurgery, Graduate School of Medicine, Oita University, Oita, Japan.

Objectives: During the anticipatory stage of swallowing, sensory stimuli related to food play an important role in the behavioral and neurophysiological aspects of swallowing. However, few studies have focused on the relationship between food preferences and oscillatory brain activity during the anticipatory stage of swallowing. Therefore, to clarify the effect of individual food preferences on oscillatory brain activity, we investigated the relationship between food preferences and oscillatory brain activity during the observation of food images. Read More

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http://dx.doi.org/10.1002/brb3.1262DOI Listing
April 2019
4 Reads

Endovascular stenting for idiopathic intracranial hypertension with venous sinus stenosis.

Brain Behav 2019 Apr 4:e01279. Epub 2019 Apr 4.

Department of Neurology, Chinese PLA General Hospital, Beijing, China.

Objectives: Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure of unknown etiology and venous sinus stenting may be an optional treatment. We aimed to evaluate the effects of venous sinus stenting on visual function, intracranial pressure, and trans-stenotic pressure gradient of the patients with IIH and to determine effects of baseline BMI or weight changes on subjective vision outcome and intracranial pressure.

Methods: From July 2009 to Aug 2016, 88 eligible patients with IIH and venous sinus stenosis who underwent stenting were retrospectively studied. Read More

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http://dx.doi.org/10.1002/brb3.1279DOI Listing

A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale.

Brain Behav 2019 Apr 2:e01283. Epub 2019 Apr 2.

Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: In recent years, increasing attention has been paid to cryptogenic stroke (CS) caused by the patent foramen ovale (PFO). This study aims to compare contrast transthoracic echocardiography (cTTE) and contrast transcranial Doppler (cTCD) to determine whether cTTE is more suitable and reliable than cTCD for clinical use.

Methods: From March 2017 to May 2018, patients who suffered from migraines, stroke, hypomnesis, or asymptomatic stroke found casually were included in our study. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1283
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http://dx.doi.org/10.1002/brb3.1283DOI Listing
April 2019
8 Reads

POLG R964C and GBA L444P mutations in familial Parkinson's disease: Case report and literature review.

Brain Behav 2019 Apr 2:e01281. Epub 2019 Apr 2.

Department of Neurology, Chang Gung Memorial Hospital at Linkou Medical Center, Taoyuan, Taiwan.

Polymerase gamma (POLG) is an enzyme responsible for the replication and repair of mitochondrial DNA. Mutations in POLG may cause variable clinical manifestations, including parkinsonism, epilepsy, cerebellar ataxia, neuropathy, and progressive external ophthalmoplegia. However, mutations of this gene are rare in patients with typical Parkinson's disease (PD). Read More

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http://dx.doi.org/10.1002/brb3.1281DOI Listing
April 2019
2 Reads

Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder.

Brain Behav 2019 Apr 2:e01275. Epub 2019 Apr 2.

Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California.

Background: Repetitive Transcranial Magnetic Stimulation (rTMS) is commonly administered to Major Depressive Disorder (MDD) patients taking psychotropic medications, yet the effects on treatment outcomes remain unknown. We explored how concomitant medication use relates to clinical response to a standard course of rTMS.

Methods: Medications were tabulated for 181 MDD patients who underwent a six-week rTMS treatment course. Read More

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http://dx.doi.org/10.1002/brb3.1275DOI Listing
April 2019
1 Read

Associated factors for cognitive impairment in the rural highly elderly.

Brain Behav 2019 Apr 1:e01203. Epub 2019 Apr 1.

Department of Preventive Medicine & Public Health, Catholic Kwandong University College of Medicine, Gangneung, Korea.

Background: Among the symptoms commonly faced by an increasingly aged population, dementia, preceded by cognitive impairment, most threatens their quality of life. Dementia is a well-recognized burden, not only for individuals who face the disease and for their families, but also for entire nation.

Aims: The purpose of this study was to identify associated factors for cognitive impairment in a very elderly population via a screening study design in Sokcho, a rural area in South Korea. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1203
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http://dx.doi.org/10.1002/brb3.1203DOI Listing
April 2019
2 Reads

Epilepsy and genetic in Rett syndrome: A review.

Brain Behav 2019 Mar 30:e01250. Epub 2019 Mar 30.

Child and Adolescent Neuropsychiatry, Medical School, University of Salerno, Fisciano, Italy.

Introduction: Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder that primarily affects girls, with an incidence of 1:10,000-20,000. The diagnosis is based on clinical features: an initial period of apparently normal development (ages 6-12 months) followed by a rapid decline with regression of acquired motor skills, loss of spoken language and purposeful hand use, onset of hand stereotypes, abnormal gait, and growth failure. The course of the disease, in its classical form, is characterized by four stages. Read More

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http://dx.doi.org/10.1002/brb3.1250DOI Listing
March 2019
4 Reads

Reduced cortical thickness related to single nucleotide polymorphisms in the major histocompatibility complex region in antipsychotic-naive schizophrenia.

Brain Behav 2019 Mar 28:e01253. Epub 2019 Mar 28.

Department of Radiology, Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China.

Instructions: The aim of this study was to explore the relationships between changes in cortical thickness and single nucleotide polymorphisms (SNPs) in the major histocompatibility complex (MHC) region in a group of antipsychotic-naive schizophrenia (AN-SCZ) patients. Methods Twenty-five AN-SCZ patients and 51 healthy controls (HCs) participated in this study. General linear models were used to identify associations between the average cortical thicknesses of each brain region (N = 68) and each of the 11 SNPs in the MHC region in the AN-SCZ patients and HCs. Read More

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http://dx.doi.org/10.1002/brb3.1253DOI Listing
March 2019
1 Read

Intracerebral transplantation of erythropoietin-producing fibroblasts facilitates neurogenesis and functional recovery in an ischemic stroke model.

Brain Behav 2019 Mar 28:e01274. Epub 2019 Mar 28.

Graduate Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Introduction: Erythropoietin (EPO) can enhance neurogenesis and fibroblasts can secrete growth factors; together, they may benefit ischemic stroke. We transplanted EPO-producing fibroblasts into the rodent infarcted brain to test their effect on neurogenesis and functional recovery.

Methods: A total of 10 cells of EPO-producing NIH/3T3 fibroblasts (EPO/EGFP/3T3) or enhanced green fluorescence protein (EGFP)-expressing fibroblasts (EGFP/3T3) were stereotaxically injected into the infarcted striatum of adult rats that received transient middle cerebral artery occlusion (MCAO) surgery 1 day poststroke. Read More

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http://dx.doi.org/10.1002/brb3.1274DOI Listing
March 2019
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Brain structural changes after multi-strategic metamemory training in older adults with subjective memory complaints: A randomized controlled trial.

Brain Behav 2019 Mar 27:e01278. Epub 2019 Mar 27.

Department of Psychiatry, Seoul National University & SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.

Background: Metamemory is the process of monitoring and controlling one's memory. Improving metamemory may reduce the memory problem in old age. We hypothesized that metamemory training (MMT) would improve cognition in older adults with subjective memory complaints and change the brain region related to metacognition. Read More

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http://dx.doi.org/10.1002/brb3.1278DOI Listing

Age-dependent sexual dimorphism in hippocampal cornu ammonis-1 perineuronal net expression in rats.

Brain Behav 2019 Mar 25:e01265. Epub 2019 Mar 25.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California.

Introduction: Perineuronal nets (PNNs) are extracellular matrices that encompass parvalbumin-expressing parvalbumin positive (PVALB+) fast-spiking inhibitory interneurons where they protect and stabilize afferent synapses. Recent observations that gonadal hormones influence PVALB+ neuron development suggest that PNN regulation may be sexually dimorphic. Sex differences in PNN abundance and complexity have been reported in sexually dimorphic nuclei in zebra finch brains; however, corresponding differences in mammalian brains have not been investigated. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1265
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http://dx.doi.org/10.1002/brb3.1265DOI Listing
March 2019
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Diagnostic and prognostic benefit of arterial spin labeling in subacute stroke.

Brain Behav 2019 Mar 25:e01271. Epub 2019 Mar 25.

Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Background And Purpose: Brain perfusion measurement in the subacute phase of stroke may support therapeutic decisions. We evaluated whether arterial spin labeling (ASL), a noninvasive perfusion imaging technique based on magnetic resonance imaging (MRI), adds diagnostic and prognostic benefit to diffusion-weighted imaging (DWI) in subacute stroke.

Methods: In a single-center imaging study, patients with DWI lesion(s) in the middle cerebral artery (MCA) territory were included. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1271
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http://dx.doi.org/10.1002/brb3.1271DOI Listing
March 2019
3 Reads

Test-retest reliability of EEG network characteristics in infants.

Brain Behav 2019 Mar 25:e01269. Epub 2019 Mar 25.

Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands.

Introduction: Functional Electroencephalography (EEG) networks in infants have been proposed as useful biomarkers for developmental brain disorders. However, the reliability of these networks and their characteristics has not been established. We evaluated the reliability of these networks and their characteristics in 10-month-old infants. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1269
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http://dx.doi.org/10.1002/brb3.1269DOI Listing
March 2019
2 Reads

Neurobiological correlates of violence perception in martial artists.

Brain Behav 2019 Mar 24:e01276. Epub 2019 Mar 24.

Department of Psychiatry and Psychotherapy, Otto-von-Guericke University, Magdeburg, Germany.

Objectives: The direct exertion as well as the visual perception of violence can have a hedonistic effect and elicit positive arousal in predisposed individuals. This appetitive aspect of aggression in healthy subjects has been neglected in psychiatric research so far.

Methods: Using functional magnetic resonance imaging, we tested whether subjects trained in sports with a violent component (martial arts) show altered brain responses in reward-associated brain areas when compared to controls. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1276
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http://dx.doi.org/10.1002/brb3.1276DOI Listing
March 2019
6 Reads

Quality of life and depression 3 months after intracerebral hemorrhage.

Brain Behav 2019 Mar 24:e01270. Epub 2019 Mar 24.

Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Objectives: Quality of life (QoL) after intracerebral hemorrhage (ICH) is poorly known. This study investigated factors affecting QoL and depression after spontaneous ICH.

Materials And Methods: This prospective study included patients admitted to Helsinki University Hospital between May 2014 and December 2016. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1270
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http://dx.doi.org/10.1002/brb3.1270DOI Listing
March 2019
9 Reads

Exonic variants of genes related to the vitamin D signaling pathway in the families of familial multiple sclerosis using whole-exome next generation sequencing.

Brain Behav 2019 Apr 21;9(4):e01272. Epub 2019 Mar 21.

Department of Neurology, Institute of Neurosciences, IdISSC, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Madrid, Spain.

Introduction: Vitamin D (VD) deficiency has been associated with multiple sclerosis (MS) and other autoimmune diseases (AIDs). However, the effect of the genetics of VD on the risk of MS is subject to debate. This study focuses on genes linked to the VD signaling pathway in families with MS. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/brb3.1272
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http://dx.doi.org/10.1002/brb3.1272DOI Listing
April 2019
4 Reads

Quantitative study of the capillaries within the white matter of the Tg2576 mouse model of Alzheimer's disease.

Brain Behav 2019 Apr 21;9(4):e01268. Epub 2019 Mar 21.

Department of Histology and Embryology, Chongqing Medical University, Chongqing, China.

Introduction: To quantitatively investigate the capillaries within the white matter of Tg2576 Alzheimer's disease (AD) transgenic mice during the early stage.

Methods: In the current study, 10-month-old male Tg2576 AD mice were used as the early-stage AD group and age-matched nontransgenic littermate mice were used as the wild-type group. Then, the Morris water maze was used to examine the spatial learning and memory abilities of the mice in both groups, and unbiased stereological methods were used to accurately quantify the volume of white matter and the parameters of the capillaries within the white matter, such as the total length, total volume, and total surface area of capillaries. Read More

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http://dx.doi.org/10.1002/brb3.1268DOI Listing
April 2019
1 Read

The potential role of auditory prediction error in decompensated tinnitus: An auditory mismatch negativity study.

Brain Behav 2019 Apr 20;9(4):e01242. Epub 2019 Mar 20.

ENT and Head & Neck Research Center and Department, The Five Senses Institute, Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Some tinnitus subjects habituate to their tinnitus but some others do not and complain of its annoyance tremendously. Normal sensory memory and change detection processes are needed for detecting the tinnitus signal as a prediction error and habituation to tinnitus. The purpose of this study was to compare auditory mismatch negativity as the index of sensory memory and change detection among the studied groups to search for the factors involving in the perception of tinnitus and preventing habituation in decompensated tinnitus subjects. Read More

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http://dx.doi.org/10.1002/brb3.1242DOI Listing

Long-term exposure to high altitude attenuates verbal and spatial working memory: Evidence from an event-related potential study.

Brain Behav 2019 Apr 20;9(4):e01256. Epub 2019 Mar 20.

Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.

Introduction: This study aimed to determine the neurocognitive basis underlying the effects of long-term high-altitude (HA) exposure on working memory (WM).

Methods: Using event-related potentials (ERPs), we compared the performance of an HA group (individuals who had lived at HA for 3 years but were born and raised at low altitude [LA]) to that of an LA group (individuals who had only lived at LA) on verbal and spatial n-back tasks (i.e. Read More

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http://dx.doi.org/10.1002/brb3.1256DOI Listing
April 2019
1 Read

The roles of alpha oscillation in working memory retention.

Brain Behav 2019 Apr 19;9(4):e01263. Epub 2019 Mar 19.

Rotman Research Institute, Baycrest Centre, Toronto, Ontario, Canada.

Introduction: Brain processes of working memory involve oscillatory activities at multiple frequencies in local and long-range neural networks. The current study addressed the specific roles of alpha oscillations during memory encoding and retention, supporting the hypothesis that multiple functional mechanisms of alpha oscillations exist in parallel.

Method: We recorded magnetoencephalography (MEG) in 25 healthy young adults, who performed a variant of a Sternberg working memory task. Read More

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http://dx.doi.org/10.1002/brb3.1263DOI Listing
April 2019
1 Read

Impairment and restrictions in possibly benign multiple sclerosis.

Brain Behav 2019 Apr 18;9(4):e01259. Epub 2019 Mar 18.

Institute of Neuroimmunology and Multiple Sclerosis, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.

Objective: The aim was to describe a broad range of health dimensions in possibly benign multiple sclerosis (MS) hypothesizing that despite some limitations there is a high adaptation to the disease.

Methods: All patients from an outpatient university clinic data registry with an Expanded Disability Status Scale (EDSS) ≤3.5 and disease duration ≥15 years were addressed in a cross-sectional study. Read More

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http://dx.doi.org/10.1002/brb3.1259DOI Listing
April 2019
1 Read

Self-reported navigation ability is associated with optic flow-sensitive regions' functional connectivity patterns during visual path integration.

Brain Behav 2019 Apr 18;9(4):e01236. Epub 2019 Mar 18.

Department of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts.

Introduction: Spatial navigation is a complex cognitive skill that varies between individuals, and the mechanisms underlying this variability are not clear. Studying simpler components of spatial navigation may help illuminate factors that contribute to variation in this complex skill; path integration is one such component. Optic flow provides self-motion information while moving through an environment and is sufficient for path integration. Read More

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http://dx.doi.org/10.1002/brb3.1236DOI Listing
April 2019
2 Reads

Assessment of dynamic functional connectivity in resting-state fMRI using the sliding window technique.

Brain Behav 2019 Apr 18;9(4):e01255. Epub 2019 Mar 18.

School of Electrical and Computer Engineering, National Technical University of Athens, Athens, Greece.

Introduction: Recent studies related to assessing functional connectivity (FC) in resting-state functional magnetic resonance imaging have revealed that the resulting connectivity patterns exhibit considerable fluctuations (dynamic FC [dFC]). A widely applied method for quantifying dFC is the sliding window technique. According to this method, the data are divided into segments with the same length (window size) and a correlation metric is employed to assess the connectivity within these segments, whereby the window size is often empirically chosen. Read More

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http://dx.doi.org/10.1002/brb3.1255DOI Listing

Motor learning enhanced by combined motor imagery and noninvasive brain stimulation is associated with reduced short-interval intracortical inhibition.

Brain Behav 2019 Apr 18;9(4):e01252. Epub 2019 Mar 18.

Shanghai Punan Hospital of Pudong New District, Shanghai, China.

Background: Motor imagery (MI) improves motor skill learning, which is further enhanced when MI is paired with primary motor cortex transcranial brain stimulation or with electrical stimulation of the peripheral median nerve. Applying both stimulation types (here with 25 ms intervals) is called paired associative stimulation (PAS25). The final primary motor cortex output is determined by combined excitatory and intracortical inhibitory circuits, and reducing the latter is associated with enhanced synaptic transmission and efficacy. Read More

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http://dx.doi.org/10.1002/brb3.1252DOI Listing

Coping strategies as moderating factors to compassion fatigue among critical care nurses.

Brain Behav 2019 Apr 18;9(4):e01264. Epub 2019 Mar 18.

Faculty of Nursing, Nursing Department, Alzaytoonah University of Jordan (ZUJ), Amman, Jordan.

Purpose: This study measured levels of compassion fatigue, burnout and satisfaction among critical care and emergency nurses. It investigated coping strategies as moderating factors and as predictors to levels of compassion fatigue.

Methods: Using a cross-sectional design, this study was conducted on 228 (84. Read More

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http://dx.doi.org/10.1002/brb3.1264DOI Listing
April 2019
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Serum soluble fibrinogen-like protein 2 concentration predicts delirium after acute pancreatitis.

Brain Behav 2019 Apr 18;9(4):e01261. Epub 2019 Mar 18.

Department of Anorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Objective: Inflammation can cause delirium. Soluble fibrinogen-like protein 2 (sFGL2) is a modulator of the immune response and more recently found to be a biomarker for brain injury. This study was designed to discover the predictive capability of serum sFGL2 concentrations for delirium after acute pancreatitis (AP). Read More

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http://dx.doi.org/10.1002/brb3.1261DOI Listing
April 2019
1 Read

Hemisphere-specific effects of prefrontal theta-burst stimulation on visual recognition memory accuracy and awareness.

Brain Behav 2019 Apr 14;9(4):e01228. Epub 2019 Mar 14.

Department of Psychology, University of North Texas, Denton, Texas.

Background: The prefrontal cortex has been implicated in episodic memory and the awareness of memory. Few studies have probed the nature and necessity of its role via brain stimulation. There are uncertainties regarding whether the hemisphere of stimulation predicts effects on memory and whether effects of stimulation are format-specific, with most previous studies utilizing verbal/semantic stimuli. Read More

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http://dx.doi.org/10.1002/brb3.1228DOI Listing

Glibenclamide ameliorates the disrupted blood-brain barrier in experimental intracerebral hemorrhage by inhibiting the activation of NLRP3 inflammasome.

Brain Behav 2019 Apr 11;9(4):e01254. Epub 2019 Mar 11.

Department of Neurosurgery, Minhang District Central hospital, Shanghai, China.

Background: Glibenclamide is a widely used sulfonylurea drug prescribed to treat type II diabetes mellitus. Previous studies have demonstrated that glibenclamide has neuroprotective effects in central nervous system injury. However, the exact mechanism by which glibenclamide acts on the blood-brain barrier (BBB) after intracerebral hemorrhage (ICH) remains unclear. Read More

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http://dx.doi.org/10.1002/brb3.1254DOI Listing

Clinical characteristics and risk score for poor clinical outcome of acute ischemic stroke patients treated with intravenous thrombolysis therapy.

Brain Behav 2019 Apr 11;9(4):e01251. Epub 2019 Mar 11.

Department of General Medicine, Yangpu Hospital Tongji University School of Medicine, Shanghai, Shanghai, China.

Background: Tissue plasminogen activator (t-PA) is an effective therapy for acute ischemic stroke, but some patients still have poor clinical outcome. In this study, we investigated clinical characteristics of stroke patients and determined predictors for poor clinical outcome in response to t-PA treatment.

Methods: Clinical data from 247 patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.1002/brb3.1251DOI Listing
April 2019
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A 5-gene prognostic nomogram predicting survival probability of glioblastoma patients.

Brain Behav 2019 Apr 11;9(4):e01258. Epub 2019 Mar 11.

Department of Biostatistics and Epidemiology, School of Public Health, Nanchang University, Nanchang, China.

Background: Glioblastoma (GBM) remains the most biologically aggressive subtype of gliomas with an average survival of 10 to 12 months. Considering that the overall survival (OS) of each GBM patient is a key factor in the treatment of individuals, it is meaningful to predict the survival probability for GBM patients newly diagnosed in clinical practice.

Material And Methods: Using the TCGA dataset and two independent GEO datasets, we identified genes that are associated with the OS and differentially expressed between GBM tissues and the adjacent normal tissues. Read More

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http://doi.wiley.com/10.1002/brb3.1258
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http://dx.doi.org/10.1002/brb3.1258DOI Listing
April 2019
3 Reads

Clinical features of freezing of gait in Parkinson's disease patients.

Brain Behav 2019 Apr 9;9(4):e01244. Epub 2019 Mar 9.

National Hospital Organization Matsue Medical Center, Matue, Japan.

Objective: To clarify the clinical features of freezing of gait (FOG) in Parkinson's disease (PD) patients by classification into two groups: Clinically observed FOG (CFOG) and self-reported FOG (SFOG).

Methods: Two hundred twenty-nine PD patients were medically examined in an examination room as well as subjected to a New Freezing of Gait Questionnaire (NFOG-Q) and analysis of nonmotor symptoms including sleep, cognition, depression, and fatigue.

Results: The prevalence of CFOG was 17. Read More

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http://dx.doi.org/10.1002/brb3.1244DOI Listing
April 2019
9 Reads

The effect of ketogenic diet on behaviors and synaptic functions of naive mice.

Brain Behav 2019 Apr 7;9(4):e01246. Epub 2019 Mar 7.

Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, School of Basic Medical Sciences, Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Introduction: Beyond its application as an epilepsy therapy, the ketogenic diet (KD) has been considered a potential treatment for a variety of other neurological and metabolic disorders. However, whether KD promotes functional restoration by reducing the pathological processes underlying individual diseases or through some independent mechanisms is not clear.

Methods: In this study, we evaluated the effect of KD on a series of behaviors and synaptic functions of young adult naive mice. Read More

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http://doi.wiley.com/10.1002/brb3.1246
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http://dx.doi.org/10.1002/brb3.1246DOI Listing
April 2019
7 Reads

Oral Lactobacillus reuteri LR06 or Bifidobacterium BL5b supplement do not produce analgesic effects on neuropathic and inflammatory pain in rats.

Brain Behav 2019 Apr 6;9(4):e01260. Epub 2019 Mar 6.

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.

Background: Previous studies have reported that certain bacteria exert visceral antinociceptive activity in visceral pain and may also help to relieve neuropathic and inflammatory pain.

Objective: The aim of this study was to explore the analgesic effect of Lactobacillus reuteri LR06 (LR06) or Bifidobacterium BL5b (BL5b) in chronic pain in vivo.

Design: Rats were randomly assigned into four groups: sham, Chronic Constriction Injury (CCI)/Complete Freund's Adjuvant (CFA) + control, CCI/CFA + LR06, and CCI/CFA + BL5b. Read More

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http://dx.doi.org/10.1002/brb3.1260DOI Listing

Mild hypothermia reduces endoplasmic reticulum stress-induced apoptosis and improves neuronal functions after severe traumatic brain injury.

Brain Behav 2019 Apr 4;9(4):e01248. Epub 2019 Mar 4.

Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.

Background: Mild hypothermia is wildly used in clinical treatment of traumatic brain injury (TBI). However, the effect of mild hypothermia on endoplasmic reticulum (ER) stress-induced apoptosis after severe TBI is still unknown.

Methods: In the present study, we used BALB/c mice to investigate the efficacy of posttraumatic mild hypothermia in reducing ER stress. Read More

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http://dx.doi.org/10.1002/brb3.1248DOI Listing
April 2019
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Muscle power, contraction velocity and functional performance after stroke.

Brain Behav 2019 Apr 28;9(4):e01243. Epub 2019 Feb 28.

Department of Physical Medicine, Medical University of Lodz, Lodz, Poland.

Objective: The goal of this study was to describe muscle function deficit in patients after stroke as well as to define the relationship between maximal muscle power (P ) and optimal shortening velocity (υ ) with functional efficiency in stroke survivors.

Material And Methods: A total of 134 participants were enrolled in the study, including 67 patients after a stroke and 67 volunteers, matched for age and sex (controls). Functional performance was measured with the timed Up and Go test (TUG) and additionally with Rivermead Motor Assessment (RMA) and Barthel Index (BI) in stroke survivors. Read More

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http://dx.doi.org/10.1002/brb3.1243DOI Listing

BIS-guided deep anesthesia decreases short-term postoperative cognitive dysfunction and peripheral inflammation in elderly patients undergoing abdominal surgery.

Brain Behav 2019 Apr 27;9(4):e01238. Epub 2019 Feb 27.

Department of Anesthesia, the Third Xiangya Hospital of Central South University, Changsha, China.

Objectives: Postoperative cognitive dysfunction (POCD) is a common clinical complication, with an underlying pathophysiology linked to heightened levels of neuroinflammation. However, it requires clarification as to whether the depth of anesthesia modulates postoperative cognitive dysfunction. This study investigated the association between depth of anesthesia and POCD in elderly patients undergoing abdominal surgery. Read More

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http://dx.doi.org/10.1002/brb3.1238DOI Listing
April 2019
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Exploring the association between Cerebral small-vessel diseases and motor symptoms in Parkinson's disease.

Brain Behav 2019 Apr 27;9(4):e01219. Epub 2019 Feb 27.

Department of Neurology, Xinhua Hospital, Affiliated to Shanghai JiaoTong University, School of Medicine, Shanghai, China.

Objectives: to explore the association between cerebral small-vessel diseases (CSVDs) and motor symptoms in Parkinson's disease (PD).

Methods: 137 PD patients were recruited into the study. Detailed motor symptoms, including tremor, rigidity, bradykinesia, and axial impairment, were evaluated using Unified Parkinson's disease Rating Scale (UPDRS). Read More

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http://dx.doi.org/10.1002/brb3.1219DOI Listing
April 2019
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Understanding cognitive functioning in glioma patients: The relevance of IDH-mutation status and functional connectivity.

Brain Behav 2019 Apr 26;9(4):e01204. Epub 2019 Feb 26.

Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands.

Introduction: Cognitive deficits occur frequently in diffuse glioma patients, but are limitedly understood. An important marker for survival in these patients is isocitrate dehydrogenase (IDH) mutation (IDH-mut). Patients with IDH-mut glioma have a better prognosis but more often suffer from epilepsy than patients with IDH-wildtype (IDH-wt) glioma, who are generally older and more often have cognitive deficits. Read More

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http://dx.doi.org/10.1002/brb3.1204DOI Listing
April 2019
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A resting-state study of volumetric and functional connectivity of the habenular nucleus in treatment-resistant depression patients.

Brain Behav 2019 Apr 25;9(4):e01229. Epub 2019 Feb 25.

Department of Mental Health, The First Hospital of Jilin University, Changchun, China.

Objective: To investigate the volumetric and functional connectivity of the habenular nucleus in treatment-resistant depression (TRD) patients using the resting-state functional magnetic resonance imaging (rs-fMRI) approach.

Methods: A total of 15 TRD patients, who visited the Mental Health Institute of the First Hospital Affiliated with Jilin University between August 2014 and March 2015, along with 15 normal subjects, were enrolled into this study for structural and functional imaging. Functional connectivity analysis was performed using bilateral habenular nuclei as the region of interest in contrast to whole-brain voxels. Read More

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http://dx.doi.org/10.1002/brb3.1229DOI Listing

Visual requirement for Chinese reading with normal vision.

Brain Behav 2019 Apr 21;9(4):e01216. Epub 2019 Feb 21.

School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Objectives: Reading performance has been considered as an effective functional endpoint for low vision. Contrary to many extensive studies for reading performance in English, there are few systematic studies for Chinese reading.

Methods: In the present study, the reading performance of 30 normally sighted Chinese college students was systematically investigated. Read More

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http://dx.doi.org/10.1002/brb3.1216DOI Listing

The knowing-doing gap in acute stroke-Does stroke knowledge translate into action?

Brain Behav 2019 Mar 20;9(3):e01245. Epub 2019 Feb 20.

Department of Neurology, Akershus University Hospital, Lørenskog, Norway.

In this study, we suggest that there is a substantial knowing-doing gap in acute stroke, as increased stroke knowledge was not associated with earlier hospital admission. Read More

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http://dx.doi.org/10.1002/brb3.1245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422823PMC

Success and failure of controlling the real-time functional magnetic resonance imaging neurofeedback signal are reflected in the striatum.

Brain Behav 2019 Mar 20;9(3):e01240. Epub 2019 Feb 20.

Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands.

Introduction: Over the last decades, neurofeedback has been applied in variety of research contexts and therapeutic interventions. Despite this extensive use, its neural mechanisms are still under debate. Several scientific advances have suggested that different networks become jointly active during neurofeedback, including regions generally involved in self-regulation, regions related to the specific mental task driving the neurofeedback and regions generally involved in feedback learning (Sitaram et al. Read More

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http://dx.doi.org/10.1002/brb3.1240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422826PMC
March 2019
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Beta oscillations in the sensorimotor cortex correlate with disease and remission in benign epilepsy with centrotemporal spikes.

Brain Behav 2019 Mar 20;9(3):e01237. Epub 2019 Feb 20.

Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts.

Introduction: Benign epilepsy with centrotemporal spikes (BECTS) is a common form of childhood epilepsy with the majority of those afflicted remitting during their early teenage years. Seizures arise from the lower half of the sensorimotor cortex of the brain (e.g. Read More

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http://doi.wiley.com/10.1002/brb3.1237
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http://dx.doi.org/10.1002/brb3.1237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422718PMC
March 2019
6 Reads

Divergent effects of repeated cocaine and novel environment exposure on locus coeruleus c-fos expression and brain catecholamine concentrations in rats.

Brain Behav 2019 Mar 20;9(3):e01222. Epub 2019 Feb 20.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan.

Introduction: Chronic administration of cocaine causes a disinhibited, hyperexploratory response to novel environments. As the norepinephrine (NE) system regulates exploration and is dysregulated following cocaine exposure, we hypothesized that this cocaine-mediated hyperexploratory response is associated with increased locus coeruleus (LC) reactivity.

Methods: To test this hypothesis, we used dual fluorescent in situ hybridization immunofluorescence to analyze novelty-induced c-fos and tyrosine hydroxylase expression in the LC and high-pressure liquid chromatography to measure dopamine (DA) and NE concentrations in key catecholamine projection regions following exposure to cocaine. Read More

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http://dx.doi.org/10.1002/brb3.1222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422811PMC