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    3699 results match your criteria Brain and Language [Journal]

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    Captive gorillas' manual laterality: The impact of gestures, manipulators and interaction specificity.
    Brain Lang 2017 Dec 13;175:130-145. Epub 2017 Nov 13.
    Max Planck Institute for Evolutionary Anthropology, Department of Primatology, Deutscher Platz 6, 04103 Leipzig, Germany. Electronic address:
    Relationships between humans' manual laterality in non-communicative and communicative functions are still poorly understood. Recently, studies showed that chimpanzees' manual laterality is influenced by functional, interactional and individual factors and their mutual intertwinement. However, what about manual laterality in species living in stable social groups? We tackled this question by studying three groups of captive gorillas (N=35) and analysed their most frequent manual signals: three manipulators and 16 gesture types. Read More

    Brain white matter structure and language ability in preschool-aged children.
    Brain Lang 2017 Nov 10;176:19-25. Epub 2017 Nov 10.
    Child & Adolescent Imaging Research (CAIR) Program, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Owerko Centre, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Department of Radiology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. Electronic address:
    Brain alterations are associated with reading and language difficulties in older children, but little research has investigated relationships between early language skills and brain white matter structure during the preschool period. We studied 68 children aged 3.0-5. Read More

    Neural correlates of quantity processing of Chinese numeral classifiers.
    Brain Lang 2017 Nov 8;176:11-18. Epub 2017 Nov 8.
    Research Center for Mind, Brain, and Learning, National Chengchi University, Taipei, Taiwan; Department of Psychology, National Chengchi University, Taipei, Taiwan. Electronic address:
    Linguistic analysis suggests that numeral classifiers carry quantity information. However, previous neuroimaging studies have shown that classifiers did not elicit higher activation in the intraparietal sulcus (IPS), associated with representation of numerical magnitude, than tool nouns did. This study aimed to control the semantic attributes of classifiers and reexamine the underlying neural correlates. Read More

    Stopping and slowing manual and spoken responses: Similar oscillatory signatures recorded from the subthalamic nucleus.
    Brain Lang 2017 Nov 7;176:1-10. Epub 2017 Nov 7.
    Krembil Research Institute, Toronto, ON, Canada; Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:
    Response control in the forms of stopping and slowing responses is thought to be implemented by a frontal-subcortical network, which includes the subthalamic nucleus (STN). For manual control, stopping is linked to STN beta (13-30 Hz) and slowing responses are linked to lower frequencies (<12 Hz). Whether similar STN oscillatory activities are associated with the control of spoken responses is not clear. Read More

    Neural correlates for naming disadvantage of the dominant language in bilingual word production.
    Brain Lang 2017 Dec 2;175:123-129. Epub 2017 Nov 2.
    State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, China. Electronic address:
    The present study investigated the neural correlates of naming disadvantage of the dominant language under the mixed language context. Twenty one unbalanced Chinese-English bilinguals completed a cued picture naming task while being scanned with functional magnetic resonance imaging (fMRI). Behavioral results showed that naming pictures in the second lanuage (L2) was significantly slower than naming pictures in the first language (L1) under a single language context. Read More

    Representation and processing of multi-word expressions in the brain.
    Brain Lang 2017 Dec 2;175:111-122. Epub 2017 Nov 2.
    School of Psychology, University of Nottingham, United Kingdom.
    Language comprehension is sensitive to the predictability of the upcoming information. Prediction allows for smooth, expedient and successful communication. While general discourse-based constraints have been investigated in detail, more specific phrase-level prediction has received little attention. Read More

    Neural oscillatory mechanisms during novel grammar learning underlying language analytical abilities.
    Brain Lang 2017 Dec 21;175:99-110. Epub 2017 Oct 21.
    Leiden University Centre for Linguistics, Postbus 9515, 2300 RA Leiden, The Netherlands; Leiden Institute for Brain and Cognition, c/o LUMC, Postzone C2-S, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
    The goal of the present study was to investigate the initial phases of novel grammar learning on a neural level, concentrating on mechanisms responsible for individual variability between learners. Two groups of participants, one with high and one with average language analytical abilities, performed an Artificial Grammar Learning (AGL) task consisting of learning and test phases. During the task, EEG signals from 32 cap-mounted electrodes were recorded and epochs corresponding to the learning phases were analysed. Read More

    Spread the word: MMN brain response reveals whole-form access of discontinuous particle verbs.
    Brain Lang 2017 Dec 20;175:86-98. Epub 2017 Oct 20.
    Brain Language Laboratory, Department of Philosophy and Humanities, Freie Universität, Berlin, Germany; Berlin School of Mind and Brain, Humboldt Universität zu Berlin, Berlin, Germany.
    The status of particle verbs such as rise (…) up as either lexically stored or combinatorially assembled is an issue which so far has not been settled decisively. In this study, we use the mismatch negativity (MMN) brain response to observe neurophysiological responses to discontinuous particle verbs. The MMN can be used to distinguish between whole-form storage and combinatorial processes, as it is enhanced to stored words compared to unknown pseudowords, whereas combinatorially legal strings elicit a reduced MMN relative to ungrammatical ones. Read More

    Commonalities and differences in the neural representations of English, Portuguese, and Mandarin sentences: When knowledge of the brain-language mappings for two languages is better than one.
    Brain Lang 2017 Dec 15;175:77-85. Epub 2017 Oct 15.
    Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA. Electronic address:
    This study extended cross-language semantic decoding (based on a concept's fMRI signature) to the decoding of sentences across three different languages (English, Portuguese and Mandarin). A classifier was trained on either the mapping between words and activation patterns in one language or the mappings in two languages (using an equivalent amount of training data), and then tested on its ability to decode the semantic content of a third language. The model trained on two languages was reliably more accurate than a classifier trained on one language for all three pairs of languages. Read More

    Intracerebral stimulation of left and right ventral temporal cortex during object naming.
    Brain Lang 2017 Dec 10;175:71-76. Epub 2017 Oct 10.
    Service de Neurologie, Centre Hospitalier Universitaire de Nancy, Nancy, France; CRAN, UMR 7039, CNRS et Université de Lorraine, Nancy, France. Electronic address:
    While object naming is traditionally considered asa left hemisphere function, neuroimaging studies have reported activations related to naming in the ventral temporal cortex (VTC) bilaterally. Our aim was to use intracerebral electrical stimulation to specifically compare left and right VTC in naming. In twenty-three epileptic patients tested for visual object naming during stimulation, the proportion of naming impairments was significantly higher in the left than in the right VTC (31. Read More

    Neural correlates of the lexicality effect in children.
    Brain Lang 2017 Dec 8;175:64-70. Epub 2017 Oct 8.
    Department of Psychology and Human Development, Vanderbilt University, Nashville, TN 37203, USA.
    The comparison of words and pseudowords has been extensively used in adult neuroimaging studies to inform neurocognitive models of reading but has rarely been used to inform models of reading acquisition. Using a rhyming judgment task, the current study examined age-related differences in the spelling to sound mapping mechanisms involved in word and pseudoword reading. We hypothesized a developmental increase in specialization of the brain mechanisms engaged for word and pseudoword processing. Read More

    Anterior cingulate cortex sulcation and its differential effects on conflict monitoring in bilinguals and monolinguals.
    Brain Lang 2017 Dec 7;175:57-63. Epub 2017 Oct 7.
    Centre for Neurolinguistics and Psycholinguistics, University Vita-Salute San Raffaele and Scientific Institute San Raffaele, Milano, Italy. Electronic address:
    The role of the anterior cingulate cortex (ACC) in modulating the effect of bilingual experience on cognitive control has been reported at both functional and structural neural levels. Individual differences in the ACC sulcal patterns have been recently correlated with cognitive control efficiency in monolinguals. We aimed to investigate whether differences of ACC sulcation mediate the effect of bilingualism on cognitive control efficiency. Read More

    Sex steroid hormones and sex hormone binding globulin levels, CYP17 MSP AI (-34T:C) and CYP19 codon 39 (Trp:Arg) variants in children with developmental stuttering.
    Brain Lang 2017 Dec 6;175:47-56. Epub 2017 Oct 6.
    Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
    Developmental stuttering is known to be a sexually dimorphic and male-biased speech motor control disorder. In the present case-control study, we investigated the relationship between developmental stuttering and steroid hormones. Serum levels of testosterone, dihydrotestosterone (DHT), dehydroepiandrosterone (DHEA), oestradiol, progesterone, cortisol, and sex hormone binding globulin (SHBG), as well as the 2nd/4th digit ratio (2D:4D), an indicator of prenatal testosterone level, were compared between children who stutter (CWS) and children who do not stutter (CWNS). Read More

    Epilepsy, language, and social skills.
    Brain Lang 2017 Oct 4. Epub 2017 Oct 4.
    UCLA David Geffen School of Medicine, Department of Psychiatry, United States. Electronic address:
    Language and social skills are essential for intrapersonal and interpersonal functioning and quality of life. Since epilepsy impacts these important domains of individuals' functioning, understanding the psychosocial and biological factors involved in the relationship among epilepsy, language, and social skills has important theoretical and clinical implications. This review first describes the psychosocial and biological factors involved in the association between language and social behavior in children and in adults and their relevance for epilepsy. Read More

    Alpha band event-related desynchronization underlying social situational context processing during irony comprehension: A magnetoencephalography source localization study.
    Brain Lang 2017 Dec 30;175:42-46. Epub 2017 Sep 30.
    Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashicho, Kodaira, Tokyo 187-8553, Japan.
    Irony comprehension requires integration of social contextual information. Previous studies have investigated temporal aspects of irony processing and its neural substrates using psychological/electroencephalogram or functional magnetic resonance imaging methods, but have not clarified the temporospatial neural mechanisms of irony comprehension. Therefore, we used magnetoencephalography to investigate the neural generators of alpha-band (8-13Hz) event-related desynchronization (ERD) occurring from 600 to 900ms following the onset of a critical sentence at which social situational contexts activated ironic representation. Read More

    Dissociable intrinsic functional networks support noun-object and verb-action processing.
    Brain Lang 2017 Dec 18;175:29-41. Epub 2017 Sep 18.
    National Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China. Electronic address:
    The processing mechanism of verbs-actions and nouns-objects is a central topic of language research, with robust evidence for behavioral dissociation. The neural basis for these two major word and/or conceptual classes, however, remains controversial. Two experiments were conducted to study this question from the network perspective. Read More

    Cerebellar induced differential polyglot aphasia: A neurolinguistic and fMRI study.
    Brain Lang 2017 Dec 14;175:18-28. Epub 2017 Sep 14.
    Centre for Neurolinguistics and Psycholinguistics, University Vita-Salute San Raffaele, Milan, Italy.
    Research has shown that linguistic functions in the bilingual brain are subserved by similar neural circuits as in monolinguals, but with extra-activity associated with cognitive and attentional control. Although a role for the right cerebellum in multilingual language processing has recently been acknowledged, a potential role of the left cerebellum remains largely unexplored. This paper reports the clinical and fMRI findings in a strongly right-handed (late) multilingual patient who developed differential polyglot aphasia, ataxic dysarthria and a selective decrease in executive function due to an ischemic stroke in the left cerebellum. Read More

    Relationship between neuronal network architecture and naming performance in temporal lobe epilepsy: A connectome based approach using machine learning.
    Brain Lang 2017 Sep 9. Epub 2017 Sep 9.
    Medical University of South Carolina, Department of Neurology, Charleston, SC, USA.
    Impaired confrontation naming is a common symptom of temporal lobe epilepsy (TLE). The neurobiological mechanisms underlying this impairment are poorly understood but may indicate a structural disorganization of broadly distributed neuronal networks that support naming ability. Importantly, naming is frequently impaired in other neurological disorders and by contrasting the neuronal structures supporting naming in TLE with other diseases, it will become possible to elucidate the common systems supporting naming. Read More

    Changes in intrinsic local connectivity after reading intervention in children with autism.
    Brain Lang 2017 Dec 3;175:11-17. Epub 2017 Sep 3.
    University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:
    Most of the existing behavioral and cognitive intervention programs in autism spectrum disorders (ASD) have not been tested at the neurobiological level, thus falling short of finding quantifiable neurobiological changes underlying behavioral improvement. The current study takes a translational neuroimaging approach to test the impact of a structured visual imagery-based reading intervention on improving reading comprehension and assessing its underlying local neural circuitry. Behavioral and resting state functional MRI (rs-fMRI) data were collected from children with ASD who were randomly assigned to an Experimental group (ASD-EXP; n=14) and a Wait-list control group (ASD-WLC; n=14). Read More

    The supramarginal and angular gyri underlie orthographic competence in Spanish language.
    Brain Lang 2017 Dec 31;175:1-10. Epub 2017 Aug 31.
    CINDFA. Grupo RIO, Guadalajara, Mexico.
    Orthographic competence allows automatic word recognition and reading fluency. To elucidate how the orthographic competence in Spanish-speaking adults might affect the neurofunctional mechanisms of visual word recognition, 32 young adults equally divided in two groups (HSS: High Spelling Skills, and LSS: Low Spelling Skills) were evaluated using fMRI methods, while they performed an orthographic recognition task involving pseudohomophones. HSS achieved significantly more correct responses and lower reaction times than LSS. Read More

    Tone-grammar association within words: Concurrent ERP and fMRI show rapid neural pre-activation and involvement of left inferior frontal gyrus in pseudoword processing.
    Brain Lang 2017 Nov;174:119-126
    Department of Linguistics, Centre for Languages and Literature, Lund University, Box 201, 221 00 Lund, Sweden. Electronic address:
    Using a concurrent ERP/fMRI paradigm, we investigated how listeners take advantage of morphologically relevant tonal information at the beginning of words to predict and pre-activate likely word endings. More predictive, low tone word stems gave rise to a 'pre-activation negativity' (PrAN) in the ERPs, a brain potential which has previously been found to increase along with the degree of predictive certainty as regards how a word is going to end. It is suggested that more predictive, low tone stems lead to rapid access to word endings with processing subserved by the left primary auditory cortex as well as the supramarginal gyrus, while high tone stems - which are less predictive - decrease predictive certainty, leading to increased competition between activated word endings, which needs to be resolved by the left inferior frontal gyrus. Read More

    Insensitivity to response-contingent feedback in adolescents with developmental language disorder (DLD).
    Brain Lang 2017 Nov;174:112-118
    Department of Communication Sciences and Disorders, University of Iowa, Iowa City 52242, USA. Electronic address:
    The aim of the study was to investigate the efficiency of the use of response-contingent feedback in adolescents with and without developmental language disorder (DLD) by using the balloon analogue risk task (BART). The BIS/BAS scales were also used to evaluate a participant's responses to reward- or punishment-related events in everyday situations. The results showed that adolescents with DLD performed on the BART at a suboptimal level due to inefficient use of response-contingent feedback. Read More

    White matter microstructure integrity in relation to reading proficiency☆.
    Brain Lang 2017 Nov 14;174:103-111. Epub 2017 Aug 14.
    Texas Institute for Measurement, Evaluation and Statistics (TIMES), and Department of Psychology, University of Houston, 4849 Calhoun Rd., Houston, TX 77204, USA.
    Components of reading proficiency such asaccuracy, fluency, and comprehension require the successful coordination of numerous, yet distinct, cortical regions. Underlying white matter tracts allow for communication among these regions. This study utilized unique residualized tract - based spatial statistics methodology to identify the relations of white matter microstructure integrity to three components of reading proficiency in 49 school - aged children with typically developing phonological decoding skills and 27 readers with poor decoders. Read More

    Resting state functional connectivity of the anterior striatum and prefrontal cortex predicts reading performance in school-age children.
    Brain Lang 2017 Nov 12;174:94-102. Epub 2017 Aug 12.
    Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
    The current study investigated the neural basis of reading performance in 60 school-age Spanish-speaking children, aged 6 to 9years. By using a data-driven approach and an automated matching procedure, we identified a left-lateralized resting state network that included typical language regions (Wernicke's and Broca's regions), prefrontal cortex, pre- and post-central gyri, superior and middle temporal gyri, cerebellum, and subcortical regions, and explored its relevance for reading performance (accuracy, comprehension and speed). Functional connectivity of the left frontal and temporal cortices and subcortical regions predicted reading speed. Read More

    Data-driven classification of patients with primary progressive aphasia.
    Brain Lang 2017 Nov 10;174:86-93. Epub 2017 Aug 10.
    German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
    Current diagnostic criteria classify primary progressive aphasia into three variants-semantic (sv), nonfluent (nfv) and logopenic (lv) PPA-though the adequacy of this scheme is debated. This study took a data-driven approach, applying k-means clustering to data from 43 PPA patients. The algorithm grouped patients based on similarities in language, semantic and non-linguistic cognitive scores. Read More

    Neural correlates of bilingual language control during interlingual homograph processing in a logogram writing system.
    Brain Lang 2017 Nov 24;174:72-85. Epub 2017 Jul 24.
    Department of Functional Brain Imaging, IDAC, Tohoku University, Sendai, Japan.
    Bilingual studies using alphabetic languages have shown parallel activation of two languages during word recognition. However, little is known about the brain mechanisms of language control during word comprehension with a logogram writing system. We manipulated the types of words (interlingual homographs (IH), cognates, and language-specific words) and the types of participants (Chinese (L1)-Japanese (L2) bilinguals vs. Read More

    Finding features, figuratively.
    Brain Lang 2017 Nov 21;174:61-71. Epub 2017 Jul 21.
    University of Pennsylvania, Department of Psychology, 425 S. University Ave., Philadelphia, PA 19104-6018, United States.
    Object concepts refer to unique clusters of properties that can be selectively activated or inhibited depending on what information is currently relevant. This conceptual "stretching" enables limitless new meanings to be generated, and figurative language provides a useful framework in which to study this conceptual flexibility. Here we probe the cognitive and neural mechanisms underlying the comprehension of novel metaphors as a means of understanding the conceptual flexibility inherent to language processing more generally. Read More

    Common variation in the autism risk gene CNTNAP2, brain structural connectivity and multisensory speech integration.
    Brain Lang 2017 Nov 22;174:50-60. Epub 2017 Jul 22.
    The Sheryl and Daniel R. Tishman Cognitive Neurophysiology Laboratory, Children's Evaluation and Rehabilitation Center (CERC), Department of Pediatrics, Albert Einstein College of Medicine & Montefiore Medical Center, Bronx, NY 10461, USA; Department of Neuroscience, Rose F. Kennedy Intellectual and Developmental Disabilities Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Ernest J. Del Monte Institute for Neuroscience, Department of Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. Electronic address:
    Three lines of evidence motivated this study. 1) CNTNAP2 variation is associated with autism risk and speech-language development. 2) CNTNAP2 variations are associated with differences in white matter (WM) tracts comprising the speech-language circuitry. Read More

    When speaker identity is unavoidable: Neural processing of speaker identity cues in natural speech.
    Brain Lang 2017 Nov 15;174:42-49. Epub 2017 Jul 15.
    MARCS Institute for Brain, Behaviour, & Development, Western Sydney University, Locked Bag 1797, Penrith, NSW 2751, Australia; ARC Centre of Excellence for the Dynamics of Language, Canberra, ACT, Australia. Electronic address:
    Speech sound acoustic properties vary largely across speakers and accents. When perceiving speech, adult listeners normally disregard non-linguistic variation caused by speaker or accent differences, in order to comprehend the linguistic message, e.g. Read More

    Reading network in dyslexia: Similar, yet different.
    Brain Lang 2017 Nov 15;174:29-41. Epub 2017 Jul 15.
    Centre for Brain Research, School of Psychology, The University of Auckland, New Zealand. Electronic address:
    Dyslexia is a developmental disorder characterized by reading and phonological difficulties, yet important questions remain regarding its underlying neural correlates. In this study, we used partial least squares (PLS), a multivariate analytic technique, to investigate the neural networks used by dyslexics while performing a word-rhyming task. Although the overall reading network was largely similar in dyslexics and typical readers, it did not correlate with behavior in the same way in the two groups. Read More

    Onset age of L2 acquisition influences language network in early and late Cantonese-Mandarin bilinguals.
    Brain Lang 2017 Nov 14;174:16-28. Epub 2017 Jul 14.
    Center for the Study of Applied Psychology, Key Laboratory of Mental Health and Cognitive Science of Guangdong Province, School of Psychology, South China Normal University, Guangzhou 510631, PR China. Electronic address:
    Early second language (L2) experience influences the neural organization of L2 in neuro-plastic terms. Previous studies tried to reveal these plastic effects of age of second language acquisition (AoA-L2) and proficiency-level in L2 (PL-L2) on the neural basis of language processing in bilinguals. Although different activation patterns have been observed during language processing in early and late bilinguals by task-fMRI, few studies reported the effect of AoA-L2 and high PL-L2 on language network at resting state. Read More

    Mens inversus in corpore inverso? Language lateralization in a boy with situs inversus totalis.
    Brain Lang 2017 Nov 11;174:9-15. Epub 2017 Jul 11.
    Department of Pediatrics and Adolescent Medicine, Medical University Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address:
    Situs inversus totalis is a rare condition where the visceral organs are organized as a mirror image of default organ position. In this study we picture the co-development between brain and visceral organs in a case of situs inversus totalis from a fetal stage to adolescence and compare our findings to an age-, gender-, and education-matched control with normal position of thoracic and abdominal organs. We show that in this case of situs inversus, functional and structural brain lateralization do not coincide with visceral organ situs. Read More

    Axon guidance pathways served as common targets for human speech/language evolution and related disorders.
    Brain Lang 2017 Nov 8;174:1-8. Epub 2017 Jul 8.
    MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:
    Human and several nonhuman species share the rare ability of modifying acoustic and/or syntactic features of sounds produced, i.e. vocal learning, which is the important neurobiological and behavioral substrate of human speech/language. Read More

    Phonological experience modulates voice discrimination: Evidence from functional brain networks analysis.
    Brain Lang 2017 Oct 27;173:67-75. Epub 2017 Jun 27.
    Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China. Electronic address:
    Numerous behavioral studies have found a modulation effect of phonological experience on voice discrimination. However, the neural substrates underpinning this phenomenon are poorly understood. Here we manipulated language familiarity to test the hypothesis that phonological experience affects voice discrimination via mediating the engagement of multiple perceptual and cognitive resources. Read More

    Atypical perceptual processing of faces in developmental dyslexia.
    Brain Lang 2017 Oct 15;173:41-51. Epub 2017 Jun 15.
    Department of Psychology, Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA.
    Developmental Dyslexia (DD) is often attributed to phonological processing deficits. Recent evidence, however, indicates the need for a more general explanatory framework to account for DD's range of deficits. The current study examined the specificity versus domain generality of DD by comparing the recognition and discrimination of three visual categories (faces and words with cars as control stimuli) in typical and dyslexic readers. Read More

    Segregating polymorphisms of FOXP2 are associated with measures of inner speech, speech fluency and strength of handedness in a healthy population.
    Brain Lang 2017 Oct 10;173:33-40. Epub 2017 Jun 10.
    Department of Psychology and Centre for Neuroscience, University of Alberta, Edmonton T6G 2R3, Canada.
    We genotyped a healthy population for three haplotype-tagging FOXP2 SNPs, and tested for associations of these SNPs with strength of handedness and questionnaire-based metrics of inner speech characteristics (ISP) and speech fluency (FLU), as derived from the Schizotypal Personality Questionnaire-BR. Levels of mixed-handedness were positively correlated with ISP and FLU, supporting prior work on these two domains. Genotype for rs7799109, a SNP previously linked with lateralization of left frontal regions underlying language, was associated with degree of mixed handedness and with scores for ISP and FLU phenotypes. Read More

    Genome-wide association study of language performance in Alzheimer's disease.
    Brain Lang 2017 Sep 31;172:22-29. Epub 2017 May 31.
    Center for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medicine, University of Washington, Seattle, WA, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
    Language impairment is common in prodromal stages of Alzheimer's disease (AD) and progresses over time. However, the genetic architecture underlying language performance is poorly understood. To identify novel genetic variants associated with language performance, we analyzed brain MRI and performed a genome-wide association study (GWAS) using a composite measure of language performance from the Alzheimer's Disease Neuroimaging Initiative (ADNI; n=1560). Read More

    Aphasia in vascular lesions of the basal ganglia: A comprehensive review.
    Brain Lang 2017 Oct 29;173:20-32. Epub 2017 May 29.
    Department of Physiotherapy, Speech Therapy, and Occupational Therapy, Faculty of Medicine, University of Sao Paulo, Rua Cipotânea, 51, Cidade Universitaria, Sao Paulo, SP 05360-160, Brazil. Electronic address:
    Between 1970 and 1990, the study of aphasia secondary to subcortical lesions (including the basal ganglia - BG) was largely driven by the advent of modern neuroimaging techniques such as MRI and PET. However, attempts to characterize a pattern of language abnormalities in patients with basal ganglia lesions proved unfruitful. We conducted a comprehensive review of language disturbances after vascular lesions in the BG. Read More

    White matter pathways mediate parental effects on children's reading precursors.
    Brain Lang 2017 Oct 27;173:10-19. Epub 2017 May 27.
    Parenting and Special Education Research Unit, Faculty of Psychology and Educational Sciences, KU Leuven, Belgium.
    Previous studies have shown that the link between parental and offspring's reading is mediated by the cognitive system of the offspring, yet information about the mediating role of the neurobiological system is missing. This family study includes cognitive and diffusion MRI (dMRI) data collected in 71 pre-readers as well as parental reading and environmental data. Using sequential path analyses, which take into account the interrelationships between the different components, we observed mediating effects of the neurobiological system. Read More

    Lesion characteristics driving right-hemispheric language reorganization in congenital left-hemispheric brain damage.
    Brain Lang 2017 Oct 23;173:1-9. Epub 2017 May 23.
    University Children's Hospital, Department of Pediatric Neurology and Developmental Medicine, University of Tübingen, Hoppe-Seyler-Str. 1, 72076 Tübingen, Germany; Clinic for Neuropediatrics and Neurorehabilitation, Epilepsy Centre for Children and Adolescents, Schön Klinik Vogtareuth, Krankenhausstr. 20, 83569 Vogtareuth, Germany.
    Pre- or perinatally acquired ("congenital") left-hemispheric brain lesions can be compensated for by reorganizing language into homotopic brain regions in the right hemisphere. Language comprehension may be hemispherically dissociated from language production. We investigated the lesion characteristics driving inter-hemispheric reorganization of language comprehension and language production in 19 patients (7-32years; eight females) with congenital left-hemispheric brain lesions (periventricular lesions [n=11] and middle cerebral artery infarctions [n=8]) by fMRI. Read More

    Comprehensibility and neural substrate of communicative gestures in severe aphasia.
    Brain Lang 2017 Aug 20;171:62-71. Epub 2017 May 20.
    Department of Neurology, Technical University Munich, Munich, Germany.
    Communicative gestures can compensate incomprehensibility of oral speech in severe aphasia, but the brain damage that causes aphasia may also have an impact on the production of gestures. We compared the comprehensibility of gestural communication of persons with severe aphasia and non-aphasic persons and used voxel based lesion symptom mapping (VLSM) to determine lesion sites that are responsible for poor gestural expression in aphasia. On group level, persons with aphasia conveyed more information via gestures than controls indicating a compensatory use of gestures in persons with severe aphasia. Read More

    Effects of contextual relevance on pragmatic inference during conversation: An fMRI study.
    Brain Lang 2017 Aug 17;171:52-61. Epub 2017 May 17.
    Center for Brain and Cognitive Sciences, Peking University, Beijing 100871, China; School of Psychological and Cognitive Sciences, Peking University, Beijing 100871, China; Key Laboratory of Computational Linguistics, Ministry of Education, Peking University, Beijing 100871, China; Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address:
    Contextual relevance, which is vital for understanding conversational implicatures (CI), engages both the frontal-temporal language and theory-of-mind networks. Here we investigate how contextual relevance affects CI processing and regulates the connectivity between CI-processing-related brain regions. Participants listened to dialogues in which the level of contextual relevance to dialogue-final utterance (reply) was manipulated. Read More

    Longitudinal decline in speech production in Parkinson's disease spectrum disorders.
    Brain Lang 2017 Aug 17;171:42-51. Epub 2017 May 17.
    Department of Neurology, Perelman School of Medicine, University of Pennsylvania, United States.
    We examined narrative speech production longitudinally in non-demented (n=15) and mildly demented (n=8) patients with Parkinson's disease spectrum disorder (PDSD), and we related increasing impairment to structural brain changes in specific language and motor regions. Patients provided semi-structured speech samples, describing a standardized picture at two time points (mean±SD interval=38±24months). The recorded speech samples were analyzed for fluency, grammar, and informativeness. Read More

    The right hemisphere's contribution to discourse processing: A study in temporal lobe epilepsy.
    Brain Lang 2017 Aug 4;171:31-41. Epub 2017 May 4.
    Epilepsy Center, Ramos Mejía Hospital, Buenos Aires, Argentina; Center for Clinical and Experimental Neuroscience: Epilepsy, Cognition and Behavior, Cell Biology and Neuroscience Institute (IBCN), School of Medicine, UBA - CONICET, Buenos Aires, Argentina; National Neuroscience and Neurosurgery Center, El Cruce Dr. Néstor Kirchner Hospital, Florencio Varela, Buenos Aires, Argentina.
    Objective: Discourse skills - in which the right hemisphere has an important role - enables verbal communication by selecting contextually relevant information and integrating it coherently to infer the correct meaning. However, language research in epilepsy has focused on single word analysis related mainly to left hemisphere processing. The purpose of this study was to investigate discourse abilities in patients with right lateralized medial temporal lobe epilepsy (RTLE) by comparing their performance to that of patients with left temporal lobe epilepsy (LTLE). Read More

    Brain potentials predict language selection before speech onset in bilinguals.
    Brain Lang 2017 Aug 23;171:23-30. Epub 2017 Apr 23.
    School of Psychology, Bangor University, LL57 2AS, UK; Centre for Research on Bilingualism, Bangor University, LL57 2AS, UK. Electronic address:
    Studies of language production in bilinguals have seldom considered the fact that language selection likely involves proactive control. Here, we show that Chinese-English bilinguals actively inhibit the language not-to-be used before the onset of a picture to be named. Depending on the nature of a directive cue, participants named a subsequent picture in their native language, in their second language, or remained silent. Read More

    The relationship between maternal education and the neural substrates of phoneme perception in children: Interactions between socioeconomic status and proficiency level.
    Brain Lang 2017 Aug 21;171:14-22. Epub 2017 Apr 21.
    Department of Neurology, Medical College of Wisconsin, Milwaukee, WI, USA.
    Relationships between maternal education (ME) and both behavioral performances and brain activation during the discrimination of phonemic and nonphonemic sounds were examined using fMRI in children with different levels of phoneme categorization proficiency (CP). Significant relationships were found between ME and intellectual functioning and vocabulary, with a trend for phonological awareness. A significant interaction between CP and ME was seen for nonverbal reasoning abilities. Read More

    How does first language (L1) influence second language (L2) reading in the brain? Evidence from Korean-English and Chinese-English bilinguals.
    Brain Lang 2017 Aug 21;171:1-13. Epub 2017 Apr 21.
    Department of Communicative Sciences and Disorders, Michigan State University, East Lansing, MI, USA. Electronic address:
    To examine how L1 influences L2 reading in the brain, two late bilingual groups, Korean-English (KE) and Chinese-English (CE), performed a visual word rhyming judgment task in their L2 (English) and were compared to L1 control groups (i.e., KK and CC). Read More

    Comprehension of concrete and abstract words in semantic variant primary progressive aphasia and Alzheimer's disease: A behavioral and neuroimaging study.
    Brain Lang 2017 Jul 20;170:93-102. Epub 2017 Apr 20.
    Département de psychologie, Université de Montréal, Montréal, QC, Canada; Centre de recherche Institut universitaire de gériatrie de Montréal (CRIUGM), Montréal, QC, Canada.
    The aim of this study was to investigate the comprehension of concrete, abstract and abstract emotional words in semantic variant primary progressive aphasia (svPPA), Alzheimer's disease (AD), and healthy elderly adults (HE) Three groups of participants (9 svPPA, 12 AD, 11 HE) underwent a general neuropsychological assessment, a similarity judgment task, and structural brain MRI. The three types of words were processed similarly in the group of AD participants. In contrast, patients in the svPPA group were significantly more impaired at processing concrete words than abstract words, while comprehension of abstract emotional words was in between. Read More

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