1,396 results match your criteria Brain Stimulation [Journal]


Acute and subsequent continuation electroconvulsive therapy elevates serum BDNF levels in patients with major depression.

Brain Stimul 2019 Feb 26. Epub 2019 Feb 26.

Department of Psychiatry and Psychotherapy, Medical University of Vienna, 1090, Vienna, Waehringerstr 18-20, Austria. Electronic address:

Introduction: The induction of brain-derived neurotrophic factor (BDNF) release and subsequent restoration of neuroplastic homeostasis may underlie the effects of electroconvulsive therapy (ECT).

Objectives: We aimed to assess serum and plasma BDNF levels during the course of acute ECT, as well as before and after subsequent continuation ECT, in patients with depression.

Methods: We included 24 patients with major depressive disorder (mean age ± SD: 54. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.015DOI Listing
February 2019

Cerebellar transcranial direct current stimulation modulates the fMRI signal in the cerebellar nuclei in a simple motor task.

Brain Stimul 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.

Background: In a seminal paper, Galea et al. (Modulation of cerebellar excitability by polarity-specific noninvasive direct current stimulation. 2009. Read More

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http://dx.doi.org/10.1016/j.brs.2019.04.002DOI Listing

Two cases of beneficial side effects from chronic electrical stimulation for treatment of focal epilepsy.

Brain Stimul 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.077DOI Listing

Comment on the letter to editor: Closed loop stimulation for tremor was invented in 1980.

Brain Stimul 2019 Apr 4. Epub 2019 Apr 4.

Medical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom.

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http://dx.doi.org/10.1016/j.brs.2019.04.001DOI Listing

Sacral nerve stimulation improves gait in Parkinson's disease.

Brain Stimul 2019 Apr 1. Epub 2019 Apr 1.

Department of Functional Neurosurgery, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.074DOI Listing
April 2019
6 Reads

Closed loop stimulation for tremor was invented in 1980.

Brain Stimul 2019 Apr 1. Epub 2019 Apr 1.

Department of Clinical Neuroscience, Umeå University, Umeå, Sweden; Unit of Functional Neurosurgery, UCL Institute of Neurology, Queen Square, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.075DOI Listing

Distilling the essence of TMS-evoked EEG potentials (TEPs): A call for securing mechanistic specificity and experimental rigor.

Brain Stimul 2019 Apr 2. Epub 2019 Apr 2.

Deutsches Resilienz Zentrum (DRZ), Johannes Gutenberg University Medical Center, Mainz, Germany; Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, Eberhard Karls University of Tübingen, Tübingen, Germany; Institute for Medical Psychology and Behavioral Neurobiology, Eberhard Karls University of Tübingen, Tübingen, Germany.

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http://dx.doi.org/10.1016/j.brs.2019.03.076DOI Listing

Analytical bias accounts for some of the reported effects of tACS on auditory perception.

Brain Stimul 2019 Mar 15. Epub 2019 Mar 15.

Exp ORL, Department of Neurosciences, The Leuven Brain Institute, KU Leuven, B-3000, Leuven, Belgium. Electronic address:

Background: Transcranial alternating current stimulation (tACS) has been shown to modulate auditory, visual, cognitive and motor function. However, tACS effects can often be small and difficult to reproduce. Thus, the establishment of robust experimental and analysis procedures is of high importance. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.011DOI Listing

Towards precise brain stimulation: Is electric field simulation related to neuromodulation?

Brain Stimul 2019 Mar 22. Epub 2019 Mar 22.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, And Berlin Institute of Health, Department of Neurology, NeuroCure Clinical Research Center, Charitéplatz 1, 10117, Berlin, Germany; Department of Neurology, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Straße, 17475, Greifswald, Germany; German Centre for Neurodegenerative Diseases (DZNE) Standort Greifswald, Greifswald, Germany. Electronic address:

Background: Recent research on neural and behavioral consequences of transcranial direct current stimulation (tDCS) has highlighted the impact of individual factors, such as brain anatomy which determines current field distribution and may thus significantly impact stimulation effects. Computational modeling approaches may significantly advance our understanding of such factors, but the association of simulation-based tDCS-induced fields and neurophysiological outcomes has not been investigated.

Objectives: To provide empirical evidence for the relationship between tDCS-induced neurophysiological outcomes and individually induced electric fields. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.072DOI Listing
March 2019
2 Reads

Individual differences in TMS sensitivity influence the efficacy of tDCS in facilitating sensorimotor adaptation.

Brain Stimul 2019 Mar 13. Epub 2019 Mar 13.

Department of Psychology, University of California, 94704, Berkeley, CA, USA; Helen Wills Neuroscience Institute, University of California, 94704, Berkeley, CA, USA.

Background: Transcranial direct current stimulation (tDCS) can enhance cognitive function in healthy individuals, with promising applications as a therapeutic intervention. Despite this potential, variability in the efficacy of tDCS has been a considerable concern.

Objective: /Hypothesis: Given that tDCS is always applied at a set intensity, we examined whether individual differences in sensitivity to brain stimulation might be one variable that modulates the efficacy of tDCS in a motor learning task. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.008DOI Listing
March 2019
3 Reads

Transcranial direct current stimulation for unipolar depression and risk of treatment emergent mania: An updated meta-analysis.

Brain Stimul 2019 Mar 18. Epub 2019 Mar 18.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, USA; VA RR&D Center for Neurorestoration and Neurotechnology, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.025DOI Listing

Significant improvement in treatment resistant auditory verbal hallucinations after 5 days of double-blind, randomized, sham controlled, fronto-temporal, transcranial direct current stimulation (tDCS): A replication/extension study.

Brain Stimul 2019 Mar 5. Epub 2019 Mar 5.

Schizophrenia Research Center, Nathan Kline Institute, Orangeburg, NY, 10962, USA; Division of Experimental Therapeutics, Department of Psychiatry, Columbia University, USA; Division of Experimental Therapeutics, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, 10032, USA.

Background: Transcranial direct current stimulation (tDCS) is a potentially novel treatment for antipsychotic-resistant auditory verbal hallucinations (AVH) in schizophrenia. Nevertheless, results have been mixed across studies.

Methods: 89 schizophrenia/schizoaffective subjects (active: 47; Sham: 42) were randomized to five days of twice-daily 20-min active tDCS vs. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.003DOI Listing
March 2019
1 Read

cTBS over contralesional homologue areas deteriorates speech output in isolated apraxia of speech after stroke.

Brain Stimul 2019 Mar 18. Epub 2019 Mar 18.

Perception and Eye Movement Laboratory, Department of Neurology, University of Bern, Switzerland; Neurocenter, Luzerner Kantonsspital, Switzerland; Gerontechnology and Rehabilitation Group, ARTORG Center for Biomedical Engineering Research University of Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.024DOI Listing

d-cycloserine blunts motor cortex facilitation after intermittent theta burst transcranial magnetic stimulation: A double-blind randomized placebo-controlled crossover study.

Brain Stimul 2019 Mar 21. Epub 2019 Mar 21.

Non-Invasive Neurostimulation Network, University of Calgary, Calgary, Alberta, Canada; Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada; The Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.026DOI Listing

Transcranial direct current stimulation in inflammatory bowel disease patients modifies resting-state functional connectivity: A RCT.

Brain Stimul 2019 Mar 5. Epub 2019 Mar 5.

Medizinische Klinik M. S. Gastroenterologie, Infektiologie und Rheumatologie, Charité -Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany; Berlin Institute of Health, 10178, Berlin, Germany. Electronic address:

Background: Chronic pain is known to be associated with functional and structural changes in the brain. Inflammatory bowel disease (IBD) presents with chronic abdominal pain in almost 35% of all patients. This study investigates structural and functional changes in magnetic resonance imaging (MRI) after transcranial direct current stimulation (tDCS) applied to ameliorate pain in IBD. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.001DOI Listing

Consistent linear and non-linear responses to invasive electrical brain stimulation across individuals and primate species with implanted electrodes.

Brain Stimul 2019 Mar 11. Epub 2019 Mar 11.

Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.

Background: Electrical neuromodulation via implanted electrodes is used in treating numerous neurological disorders, yet our knowledge of how different brain regions respond to varying stimulation parameters is sparse.

Objective/hypothesis: We hypothesized that the neural response to electrical stimulation is both region-specific and non-linearly related to amplitude and frequency.

Methods: We examined evoked neural responses following 400 ms trains of 10-400 Hz electrical stimulation ranging from 0. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.007DOI Listing

Deep transcranial magnetic stimulation (dTMS) for treatment of major depressive disorder (MDD) status post-surgical removal of medulloblastoma: A case report of safety.

Brain Stimul 2019 Mar 12. Epub 2019 Mar 12.

Keystone Rural Health Center, Keystone Behavioral Health, 110 Chambers Hill Dr, Chambersburg, PA, 17201, United States.

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http://dx.doi.org/10.1016/j.brs.2019.03.010DOI Listing
March 2019
2 Reads

Combined endogenous and exogenous disinhibition of intracortical circuits augments plasticity induction in the human motor cortex.

Brain Stimul 2019 Mar 12. Epub 2019 Mar 12.

Division of Functional and Restorative Neurosurgery, Tuebingen NeuroCampus, Eberhard Karls University Tuebingen, Tuebingen, Germany. Electronic address:

Background: Motor imagery (MI) engages cortical areas in the human brain similar to motor practice. Corticospinal excitability (CSE) is facilitated during but not after MI practice. We hypothesized that lasting CSE changes could be achieved by associatively pairing this endogenous modulation with exogenous stimulation of the same intracortical circuits. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.009DOI Listing

Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation.

Brain Stimul 2019 Mar 6. Epub 2019 Mar 6.

Department of Radiology, Stanford University, Stanford, CA, USA; Department of Bioengineering, Stanford University, Stanford, CA, USA; Department of Electrical Engineering, Stanford University, Stanford, CA, USA.

Background: Recent studies in a variety of animal models including rodents, monkeys, and humans suggest that transcranial focused ultrasound (tFUS) has considerable promise for non-invasively modulating neural activity with the ability to target deep brain structures. However, concerns have been raised that motor responses evoked by tFUS may be due to indirect activation of the auditory pathway rather than direct activation of motor circuits.

Objective: In this study, we sought to examine the involvement of peripheral auditory system activation from tFUS stimulation applied to elicit motor responses. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.005DOI Listing

Bony encapsulation of a NeuroPace subdural electrode.

Brain Stimul 2019 Mar 4. Epub 2019 Mar 4.

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, UT, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.02.025DOI Listing

Robust clinical benefit of multi-target deep brain stimulation for treatment of Gilles de la Tourette syndrome and its comorbidities.

Brain Stimul 2019 Mar 4. Epub 2019 Mar 4.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.02.026DOI Listing
March 2019
1 Read

Decreasing battery life in subthalamic deep brain stimulation for Parkinson's disease with repeated replacements: Just a matter of energy delivered?

Brain Stimul 2019 Feb 22. Epub 2019 Feb 22.

Movement Disorders Institute and Department of Neurology, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel.

Background: People with Parkinson's disease (PD) treated with deep brain stimulation (DBS) with non-rechargeable implantable pulse generators (IPGs) require elective IPG replacement operations involving surgical and anesthesiologic risk. Life expectancy and the number of replacements per patient with DBS are increasing.

Objective: To determine whether IPG longevity is influenced by stimulation parameters alone or whether there is an independent effect of the number of battery replacements and IPG model. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.008DOI Listing
February 2019
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Is awake physiological confirmation necessary for DBS treatment of Parkinson's disease today? A comparison of intraoperative imaging, physiology, and physiology imaging-guided DBS in the past decade.

Brain Stimul 2019 Mar 7. Epub 2019 Mar 7.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, PR China. Electronic address:

Background: Deep brain stimulation (DBS) is a well-established surgical therapy for Parkinson's disease (PD). Intraoperative imaging (IMG), intraoperative physiology (PHY) and their combination (COMB) are the three mainstream DBS guidance methods.

Objective: To comprehensively compare the use of IMG-DBS, PHY-DBS and COMB-DBS in treating PD. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.006DOI Listing
March 2019
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Supplementary motor area plays a causal role in automatic inhibition of motor responses.

Brain Stimul 2019 Mar 6. Epub 2019 Mar 6.

Department of Neurology, Division of Neuroscience, Graduate School of Medicine, The University of Tokyo. 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan; Department of Cell Physiology, Kyorin University 6-20-2 Shinkawa, Mitaka-shi, Tokyo, 181-8611, Japan.

Background: The masked-priming paradigm is used to test unconscious inhibitory processes of the brain. A tendency towards responses that are incompatible with the prime, designated as negative compatibility effect (NCE), emerges when the perception of a priming visual stimulus is "masked" afterwards. This effect presumably stems from a subliminal inhibitory process against the masked-prime. Read More

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http://dx.doi.org/10.1016/j.brs.2019.03.002DOI Listing

Transcutaneous auricular vagus nerve stimulation in treating post-stroke insomnia monitored by resting-state fMRI: The first case report.

Brain Stimul 2019 Feb 21. Epub 2019 Feb 21.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.02.016DOI Listing
February 2019
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Blinding success of sham-controlled motor cortex intermittent theta burst stimulation based on participant perceptions.

Brain Stimul 2019 Mar 6. Epub 2019 Mar 6.

Department of Human Sciences, The Ohio State University, Columbus, OH, 43210, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.03.004DOI Listing

Letter to the editor: Thalamic deep brain stimulation may relieve breathlessness in COPD.

Brain Stimul 2019 Mar 2. Epub 2019 Mar 2.

Cardiorespiratory Research Group, Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.02.019DOI Listing

Increased dopamine transporter levels following nucleus accumbens deep brain stimulation in methamphetamine use disorder: A case report.

Brain Stimul 2019 Mar 1. Epub 2019 Mar 1.

Department of Functional Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.02.023DOI Listing

Efficacy and safety of multiple sessions of quadripulse stimulation in patients with stroke: A report of two cases.

Brain Stimul 2019 Feb 23. Epub 2019 Feb 23.

Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.brs.2019.02.017DOI Listing
February 2019

TMS-EEG approach unveils brain mechanisms underlying conscious and unconscious face perception.

Brain Stimul 2019 Feb 27. Epub 2019 Feb 27.

Department of Psychology, Università degli Studi di Milano-Bicocca, Milano, 20126, Italy; CeRiN (Centro di Riabilitazione Neurocognitiva), CiMeC, Università degli Studi di Trento, Rovereto, 38068, Italy.

Background: Conscious perception of external stimuli has been related to recurrent activity in distributed cortical networks, although brain mechanisms controlling unconscious processing and stimuli access to conscious report need to be clarified.

Objective: This study aims at investigating modulations in cortical excitability related to conscious perception and unconscious processing of face stimuli with different visibility levels.

Methods: We used TMS-EEG over the right occipital face area (rOFA), or the right premotor cortex (rPMC) as control site, to measure cortical excitability during a backward masking paradigm with individually defined stimuli visibility. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.022DOI Listing
February 2019

Does rTMS treat insomnia?

Brain Stimul 2019 Feb 23. Epub 2019 Feb 23.

Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, 997 St. Sebastian Way, Augusta, GA30912, USA.

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http://dx.doi.org/10.1016/j.brs.2019.02.004DOI Listing
February 2019
1 Read

Somatosensory and transcranial direct current stimulation effects on manual dexterity and motor cortex function: A metaplasticity study.

Brain Stimul 2019 Feb 26. Epub 2019 Feb 26.

Department of Exercise Sciences, University of Auckland, Auckland, New Zealand; Centre for Brain Research, University of Auckland, Auckland, New Zealand. Electronic address:

Background: Non-invasive neuromodulation may provide treatment strategies for neurological deficits affecting movement, such as stroke. For example, weak electrical stimulation applied to the hand by wearing a "mesh glove" (MGS) can transiently increase primary motor cortex (M1) excitability. Conversely, transcranial direct current stimulation with the cathode over M1 (c-tDCS) can decrease corticomotor excitability. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.010DOI Listing
February 2019
2 Reads

Slow oscillatory transcranial direct current stimulation (so-tDCS) during slow wave sleep has no effects on declarative memory in healthy young subjects.

Brain Stimul 2019 Feb 21. Epub 2019 Feb 21.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Competence Center for Sleep Medicine, Germany.

Background: The manipulation of specific brain oscillations by applying transcranial electrical stimulation techniques in order to enhance memory processes during sleep has become an intriguing field of research. A seminal study found a positive effect of slow-oscillatory transcranial direct current stimulation (so-tDCS) on sleep-dependent consolidation of declarative memories. Since then several studies have tried to replicate this result with inconsistent findings. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.012DOI Listing
February 2019

Battery longevity of neurostimulators in Parkinson disease: A historic cohort study.

Brain Stimul 2019 Feb 25. Epub 2019 Feb 25.

Department of Neurology, Grenoble Alpes University Hospital, Grenoble, France; Grenoble Institute of Neurosciences GIN-INSERM U1216/CEA/UGA, Grenoble, France; Grenoble Alpes University, Grenoble, France. Electronic address:

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for motor complications in Parkinson disease (PD). Since 2012, the nonrechargeable dual-channel neurostimulator available in France seems to have shorter battery longevity compared to the same manufacturer's previous model.

Objective: The aim of this study was to evaluate the battery longevity of older and more recent neurostimulators from the same manufacturer and to explore factors associated with battery life variations. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1935861X193005
Publisher Site
http://dx.doi.org/10.1016/j.brs.2019.02.006DOI Listing
February 2019
9 Reads

Pharmacophysiology of TMS-evoked EEG potentials: A mini-review.

Brain Stimul 2019 Feb 25. Epub 2019 Feb 25.

Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.02.021DOI Listing
February 2019
1 Read

Modulatory mechanisms underlying high-frequency transcranial random noise stimulation (hf-tRNS): A combined stochastic resonance and equivalent noise approach.

Brain Stimul 2019 Feb 26. Epub 2019 Feb 26.

University of Lincoln, School of Psychology, Brayford Wharf East, Lincoln, LN5 7AY, United Kingdom.

Background: High-frequency transcranial random noise stimulation (hf-tRNS) is a neuromodulatory technique consisting of the application of alternating current at random intensities and frequencies. hf-tRNS induces random neural activity in the system that may boost the sensitivity of neurons to weak inputs. Stochastic resonance is a nonlinear phenomenon whereby the addition of an optimal amount of noise results in performance enhancement, whereas further noise increments impair signal detection or discrimination. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.018DOI Listing
February 2019
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Dual threshold neural closed loop deep brain stimulation in Parkinson disease patients.

Brain Stimul 2019 Feb 25. Epub 2019 Feb 25.

Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, Stanford, CA, USA; Department of Neurosurgery, School of Medicine, Stanford University, Stanford, CA, USA. Electronic address:

Background: Closed loop deep brain stimulation (clDBS) in Parkinson's disease (PD) using subthalamic (STN) neural feedback has been shown to be efficacious only in the acute post-operative setting, using externalized leads and stimulators.

Objective: To determine feasibility of neural (N)clDBS using the clinical implanted neurostimulator (Activa™ PC + S, FDA IDE approved) and a novel beta dual threshold algorithm in tremor and bradykinesia dominant PD patients on chronic DBS.

Methods: 13 PD subjects (20 STNs), on open loop (ol)DBS for 22 ± 7. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.020DOI Listing
February 2019
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Increased perseverative errors following high-definition transcranial direct current stimulation over the ventrolateral cortex during probabilistic reversal learning.

Brain Stimul 2019 Feb 21. Epub 2019 Feb 21.

Cognitive Neuroscience Unit, School of Psychology, Deakin University, Geelong, Victoria, Australia.

Background: The prefrontal cortex regulates behavioural adaptation in response to feedback. However, the causal role of different prefrontal regions remains unclear, based on indirect evidence derived from functional neuroimaging. Neuroimaging studies show dorsomedial prefrontal activation during feedback monitoring, whereas the ventrolateral prefrontal cortex engages during behavioural adaptation (shifting). Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.013DOI Listing
February 2019
3 Reads

Decoding voluntary movements and postural tremor based on thalamic LFPs as a basis for closed-loop stimulation for essential tremor.

Brain Stimul 2019 Feb 21. Epub 2019 Feb 21.

Medical Research Council Brain Network Dynamics Unit at the University of Oxford, OX1 3TH, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, OX3 9DU, Oxford, United Kingdom. Electronic address:

Background: High frequency Deep brain stimulation (DBS) targeting motor thalamus is an effective therapy for essential tremor (ET). However, conventional continuous stimulation may deliver unnecessary current to the brain since tremor mainly affects voluntary movements and sustained postures in ET.

Objective: We aim to decode both voluntary movements and the presence of postural tremor from the Local field potentials (LFPs) recorded from the electrode implanted in motor thalamus for stimulation, in order to close the loop for DBS so that stimulation could be delivered on demand, without the need for peripheral sensors or additional invasive electrodes. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.011DOI Listing
February 2019

Transcranial electrical stimulation improves phoneme processing in developmental dyslexia.

Brain Stimul 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurology, Otto-von-Guericke University, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany.

Background: About 10% of the western population suffers from a specific disability in the acquisition of reading and writing skills, known as developmental dyslexia (DD). Even though DD starts in childhood it frequently continuous throughout lifetime. Impaired processing of acoustic features at the phonematic scale based on dysfunctional auditory temporal resolution is considered as one core deficit underlying DD. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.007DOI Listing
February 2019
1 Read

Photobiomodulation in Parkinson's disease: A randomized controlled trial.

Brain Stimul 2019 Feb 20. Epub 2019 Feb 20.

European University of Madrid (Faculty of Sport Sciences) and Research Institute Hospital 12 de Octubre ('i+12'), Madrid, Spain.

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http://dx.doi.org/10.1016/j.brs.2019.02.009DOI Listing
February 2019
5 Reads

Efficacy of pre-supplementary motor area transcranial direct current stimulation for treatment resistant obsessive compulsive disorder: A randomized, double blinded, sham controlled trial.

Brain Stimul 2019 Feb 13. Epub 2019 Feb 13.

Obsessive Compulsive Disorder Clinic, Department of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), 560029, India.

Background: A significant proportion of obsessive compulsive disorder (OCD) patients do not respond to specific serotonin reuptake inhibitors (SSRIs). There is a need to evaluate novel treatment options for OCD.

Objective: In this double blinded, randomized, sham controlled study, we investigated the efficacy of add-on transcranial direct current stimulation (tDCS) in reducing the symptoms in SSRI-resistant OCD patients by employing anodal pre-supplementary motor area (pre-SMA) stimulation. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.005DOI Listing
February 2019
1 Read

The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field (7T) fMRI study.

Brain Stimul 2019 Feb 10. Epub 2019 Feb 10.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Logan University, Chesterfield, MO, USA.

Background: Brainstem-focused mechanisms supporting transcutaneous auricular VNS (taVNS) effects are not well understood, particularly in humans. We employed ultrahigh field (7T) fMRI and evaluated the influence of respiratory phase for optimal targeting, applying our respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) technique.

Hypothesis: We proposed that targeting of nucleus tractus solitarii (NTS) and cardiovagal modulation in response to taVNS stimuli would be enhanced when stimulation is delivered during a more receptive state, i. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.003DOI Listing
February 2019
1 Read

Neurophysiological effect of transorbital electrical stimulation: Early results in advanced optic atrophy.

Brain Stimul 2019 Feb 7. Epub 2019 Feb 7.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Neurology Institute, Università Cattolica del Sacro Cuore, Rome, Italy.

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http://dx.doi.org/10.1016/j.brs.2019.02.002DOI Listing
February 2019

Evidence for associative plasticity in the human visual cortex.

Brain Stimul 2019 Feb 1. Epub 2019 Feb 1.

Research Unit of Neurology, Neurophysiology and Neurobiology, Università Campus Bio-Medico, Roma, Italy; Fondazione Alberto Sordi-Research Institute for Aging, Roma, Italy.

Background: Repetitive convergent inputs to a single post-synaptic neuron can induce long-term potentiation (LTP) or depression (LTD) of synaptic activity in a spike timing-dependent manner.

Objective: Here we set a protocol of visual paired associative stimulation (vPAS) of the primary visual cortex (V1) in humans to induce persistent changes in the excitatory properties of V1 with a spike timing rule.

Methods: We provided convergent inputs to V1 by coupling transcranial magnetic stimulation (TMS) pulses of the occipital cortex with peripheral visual inputs, at four interstimulus intervals of -50/-25/+25/+50 ms relative to the visual evoked potential (VEP) P1 latency. Read More

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http://dx.doi.org/10.1016/j.brs.2019.01.021DOI Listing
February 2019
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Psychogenic non-epileptic seizures treated with guided transcranial direct current stimulation: A case report.

Brain Stimul 2019 Jan 31. Epub 2019 Jan 31.

CHU Lille, Hôpital Fontan, Department of Psychiatry, F-59000, Lille, France; Univ. Lille, CNRS UMR-9193, SCALab - Sciences Cognitives et Sciences Affectives, France; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Introduction: Psychogenic non-epileptic seizures (PNES) are paroxysms of either altered subjective or objective manifestations that may mimic epileptic seizures (ES), without abnormal neuronal epileptiform activity. In this report, we present the case of a 39-year-old woman with PNES and functional movement disorders, who was successfully treated with neuro-guided transcranial direct current stimulation (tDCS).

Methods: We used a PET-guided tDCS approach, as a hypometabolism of the frontal region was revealed by FDG TEP scan. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1935861X193005
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http://dx.doi.org/10.1016/j.brs.2019.01.019DOI Listing
January 2019
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Chronic brain stimulation rewarding experience ameliorates depression-induced cognitive deficits and restores aberrant plasticity in the prefrontal cortex.

Brain Stimul 2019 Jan 31. Epub 2019 Jan 31.

Department of Neurophysiology, National Institute of Mental Health and Neuro Sciences, Hosur Road, Bengaluru, 560 029, India. Electronic address:

Background: Major depressive disorder (MDD) is a multifactorial disease which often coexists with cognitive deficits. Depression-induced cognitive deficits are known to be associated with aberrant reward processing, neurochemical and structural alterations. Recent studies have shown that chronic electrical stimulation of brain reward areas induces a robust antidepressant effect. Read More

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http://dx.doi.org/10.1016/j.brs.2019.01.020DOI Listing
January 2019