8,670 results match your criteria Brain Research Bulletin[Journal]


Therapeutic Efficacy of Glial Cell-Derived Neurotrophic Factor Loaded Collagen Scaffolds in ex vivo organotypic brain slice Parkinson's Disease Models.

Brain Res Bull 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Psychiatry and Experimental Alzheimer's Research, Medical University of Innsbruck, Austria. Electronic address:

Glial cell line-derived neurotrophic factor (GDNF) is a potent trophic factor that supports the survival of dopaminergic neurons of the substantia nigra (SN), which degenerate in Parkinson's disease (PD). The application of GDNF to the brain is challenging but biomaterials such as collagen can present novel strategies to target therapeutics to the brain. In this study, we assess the efficacy of collagen scaffolds loaded with GDNF on dopaminergic neuronal survival in organotypic ex vivo slices: axotomy, rotenone, and 6-hydroxydopamine (6-OHDA) models. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.012DOI Listing
April 2019
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miR-124 upregulates astrocytic glutamate transporter-1 via the Akt and mTOR signaling pathway post ischemic stroke.

Brain Res Bull 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Wuxi People's Hospital of Nanjing Medical University, 299 Qingyang Road, Wuxi, 214023, People's Republic of China. Electronic address:

High-concentration glutamic acid (Glu) induced by ischemic stroke can be inhibited by glutamate transporter-1 (GLT-1), which is the main mechanism for preventing excessive extracellular glutamate accumulation in the central nervous system. Upregulation of miR-124 could reduce the infarct area and promote the recovery of neurological function after ischemic stroke. A previous study investigated whether miR-124 could regulate GLT-1 expression in normal culture conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183060
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.013DOI Listing
April 2019
1 Read

Proconvulsant effects of sildenafil citrate on pilocarpine-induced seizures: involvement of cholinergic, nitrergic and pro-oxidant mechanisms.

Brain Res Bull 2019 Apr 17. Epub 2019 Apr 17.

Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Department of Physiology and Pharmacology, Universidade Federal do Ceará, Fortaleza, CE, Brazil; Pharmacy Department, Faculty of Dentistry, Nursing and Pharmacy, Universidade Federal do Ceará, Fortaleza, CE, Brazil. Electronic address:

Sildenafil is a phosphodiesterase 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. Proconvulsant effect is a serious adverse event associated with sildenafil use. Here, we investigated the possible proconvulsant effects of sildenafil in pilocarpine (PILO)-induced seizures model, which mimics some aspects of temporal lobe epilepsy. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.008DOI Listing

XPro1595 ameliorates bone cancer pain in rats via inhibiting p38-mediated glial cell activation and neuroinflammation in the spinal dorsal horn.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, Preclinical School of Medicine, The Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:

Bone cancer pain (BCP) profoundly compromises the life quality of patients with bone metastases. Severe side effects of the drugs which were widely used and effective in the various stages of this condition results in a huge challenge for BCP treatment. Here, we investigated the antinociceptive effects of XPro1595, a soluble tumor necrosis factor (solTNF) inhibitor with considerable immunoregulatory efficacy, on BCP, as well as the underlying mechanisms within the spinal dorsal horn (SDH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183053
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.009DOI Listing
April 2019
2 Reads

Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-00 Criciúma, SC, Brazil. Electronic address:

In the central nervous system, glial cells protect the brain against neuronal stress by inducing inflammatory responses; namely, intracellular signaling and cytokine production. However, chronic inflammation is often associated with degenerative diseases that can damage hormone signaling and mitochondrial function. Lipopolysaccharide (LPS) induces neuroinflammation by stimulating the production of interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α); moreover, it generates oxidative stress and impairs cognitive functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183094
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.011DOI Listing
April 2019
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RTN1-C is involved in high glucose-aggravated neuronal cell subjected to oxygen-glucose deprivation and reoxygenation injury via endoplasmic reticulum stress.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230032, China. Electronic address:

Background: Patients suffering from diabetes mellitus experience poor outcomes after ischemic stroke. RTN1-C, ER-associated proteins localized in endoplasmic reticulum (ER) membrane, plays an important role in ER stress-induced apoptosis and regulates cellular susceptibility to different apoptosis pathways. Overexpression of RTN1-C can aggravate cerebral ischemia/reperfusion injury (IRI). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.010DOI Listing

Protective Effects of Mesenchymal Stem Cells Overexpressing Extracellular Regulating Kinase 1/2 Against Stroke in Rats.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Neurology, Shanghai Tongji hospital, Tongji University School of Medicine, Shanghai, 200065, China. Electronic address:

Objective: Although transplantation of bone marrow-derived mesenchymal stem cells (MSCs) has shown beneficial effects on stroke, lower survival of MSCs limits effects. Extracellular regulating kinase 1/2 signaling (ERK1/2) is crucial for cell survival, differentiation, and proliferation. This study was designed to explore whether MSCs modified by over-expressing ERK1/2 may reinforce beneficial effects on stroke in rats. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183021
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.006DOI Listing
April 2019
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Ca-PKCα-ERK1/2 signaling pathway is involved in the suppressive effect of propofol on proliferation of neural stem cells from the neonatal rat hippocampus.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, PR China. Electronic address:

Neonatal exposure to propofol induces persistent behavioral abnormalities in adulthood. In addition to triggering the apoptosis of neurons in the developing brain, anesthetics may contribute to the development of cognitive deficits by interfering neurogenesis. Given the importance of neural stem cell (NSC) proliferation in neurogenesis, the effect of propofol on NSC proliferation and the mechanisms underlying this effect were investigated. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.005DOI Listing

Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.

Brain Res Bull 2019 Apr 9. Epub 2019 Apr 9.

Unidad de Investigación Médica en Enfermedades Neurológicas, Hospital de Especialidades, "Dr. Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, IMSS, Ciudad de México, México. Electronic address:

During critical periods of neurodevelopment, the immature brain is susceptible to neuronal hyperexcitability, alterations such as hyperthermia, hypoxia, brain trauma or a preexisting neuroinflammatory condition can trigger, promote and prolong epileptiform activity and facilitate the development of epilepsy. The goal of the present study was to evaluate the long-term neuroprotective effects Magnolia officinalis extract, on a model of recurrent status epilepticus (SE) in immature rats. Sprague-Dawley rats were treated with kainic acid (KA) (3 mg/kg, dissolved in saline solution) beginning at day 10 P N every 24 hrs for five days (10 P N-14PN). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.003DOI Listing
April 2019
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The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress.

Brain Res Bull 2019 Apr 4;149:1-10. Epub 2019 Apr 4.

Department of Histology and Embryology, Chongqing Medical University, Chongqing, 400016, PR China; Laboratory of Stem Cells and Tissue Engineering, Chongqing Medical University, Chongqing, 400016, PR China. Electronic address:

Running exercise has been shown to be associated with decreased symptoms of depression. However, the mechanisms underlying these antidepressant effects of running exercise remain relatively unclear. In the current study, we investigated the relationship between depressive symptoms in chronic unpredictable stress (CUS) model rats treated with running exercise and changes in oligodendrocytes in the hippocampus. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.001DOI Listing
April 2019
5 Reads
2.718 Impact Factor

Establishment of a novel mesial temporal lobe epilepsy rhesus monkey model via intra-hippocampal and intra-amygdala kainic acid injection assisted by neurosurgical robot system.

Brain Res Bull 2019 Apr 4. Epub 2019 Apr 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China; Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100070, China; Beijing Key Laboratory of Neurostimulation, Beijing, 100070, China. Electronic address:

Background: Mesial temporal lobe epilepsy (mTLE) is the most common type of refractory epilepsy, and non-human primate (NHP) models are important to investigate its mechanism and therapy. However, previous mTLE-NHP models have some defects.

Methods: Thirteen rhesus monkeys were randomly assigned to a control group and epilepsy group. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.002DOI Listing
April 2019
2 Reads

Concerted suppression of I and activation of I by ivabradine, an HCN-channel inhibitor, in pituitary cells and hippocampal neurons.

Brain Res Bull 2019 Apr 3;149:11-20. Epub 2019 Apr 3.

Institute of Basic Medical Sciences, National Cheng Kung University Medical College, Tainan City, Taiwan; Department of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan. Electronic address:

Ivabradine (IVA), a heart-rate reducing agent, is recognized as an inhibitor of hyperpolarization-activated cation current (I) and also reported to ameliorate inflammatory or neuropathic pain. However, to what extent this agent can perturb another types of membrane ion currents in neurons or endocrine cells remains to be largely unknown. Therefore, the I or other types of ionic currents in pituitary tumor (GH) cells and in hippocampal mHippoE-14 neurons was studied with or without the presence of IVA or other related compounds. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.016DOI Listing
April 2019
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2.718 Impact Factor

miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.

Brain Res Bull 2019 Apr 1. Epub 2019 Apr 1.

Department of Neurosurgery and Pituitary Tumor Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Prolactinoma is a common subtype of pituitary tumors. Dopamine receptor agonists are the preferred treatment for prolactinoma; however, with this therapy, drug resistance often occurs. In our previous work, we found that partial resistant prolactinomas showed increased fibrosis and that the transforming growth factor (TGF)-β1/Smad3 signaling pathway mediated fibrosis and was involved in drug resistance. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.013DOI Listing
April 2019
4 Reads

Role of toll-like receptor 4 in the regulation of the cell death pathway and neuroinflammation.

Brain Res Bull 2019 Mar 30;148:79-90. Epub 2019 Mar 30.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth, Defects of Ministry of Education, Sichuan University, Chengdu 610041, China. Electronic address:

Septic brain injury is a severe disease of the central nervous system and involves alteration of the cell death pathway due to sepsis. Increasing evidence indicates that Toll-like receptor 4 (TLR4) plays a key role in the development of sepsis. Cell death is also thought to contribute to septic brain injury. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.015DOI Listing
March 2019
3 Reads
2.718 Impact Factor

Harpagide inhibits neuronal apoptosis and promotes axonal regeneration after spinal cord injury in rats by activating the Wnt/β-catenin signaling pathway.

Brain Res Bull 2019 Mar 30;148:91-99. Epub 2019 Mar 30.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Nanjing Medical University, China. Electronic address:

The neuronal apoptosis program associated with spinal cord injury (SCI) has a severe impact on spinal cord function, which leads to further secondary and permanent neuronal damage that may cause irreparable damage to the central nervous system. Activation of the Wnt/β-catenin signaling pathway is effective in reducing apoptosis and preventing SCI. Harpagide is one of the main active constituents of the iridoid class of molecules, which have neuroprotective effects after SCI. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.014DOI Listing

The single intravenous administration of mitochondria-targeted antioxidant SkQR1 after traumatic brain injury attenuates neurological deficit in rats.

Brain Res Bull 2019 Mar 29;148:100-108. Epub 2019 Mar 29.

Research Center of Neurology, Volokolamskoe Shosse 80, 125367, Moscow, Russia; M.V. Lomonosov Moscow State University, A.N. Belozersky Institute of Physico-Chemical Biology, 119991, Moscow, Russia; M.V. Lomonosov Moscow State University, Biological Faculty, 119234, Moscow, Russia. Electronic address:

The protective effect of SkQR1, a mitochondria-targeted antioxidant, was investigated on the model of focal one-sided traumatic brain injury (TBI) of the sensorimotor cortex region from 1 to 7 days after the injury. TBI caused a reliable disruption of the functions of the limbs contralateral to injury focus. The intravenous single injection of SkQR1 (250 nmol/kg) but not C12R1 (a SkQR1 homologue devoid of the antioxidant group) 30 min after TBI reduced the impairment of the motor functions of the limbs. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.011DOI Listing
March 2019
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The protection of New Interacting Motif E shot (NIMoEsh) in mice with collagenase-induced acute stage of intracerebral hemorrhage.

Brain Res Bull 2019 Mar 30;148:70-78. Epub 2019 Mar 30.

Department of Pathology, First Clinical Hospital, Harbin Medical University, Harbin, 150001, China. Electronic address:

Aberrant c-Jun N terminal kinase (JNK) activation is broadly involved in the pathogenesis of several acute and chronic neurological diseases. However, the mechanism of JNK activation leading to aggravation of injury after ICH remains unclear. In this study, we confirmed that using NIMoEsh to inhibit JNK activation effectively reduced the level of brain injury following ICH. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.012DOI Listing
March 2019
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Pharmacology of P2Y receptors.

Brain Res Bull 2019 Mar 25. Epub 2019 Mar 25.

Department of Pharmacology and Toxicology, Pharma Center, University of Bonn, D-53127, Bonn, Germany. Electronic address:

P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups (P2Y, P2Y, P2Y, P2Y, and P2Y) and (P2Y, P2Y, and P2Y). The P2Y receptors are expressed in various cell types and play important roles in physiology and pathophysiology including inflammatory responses and neuropathic pain. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.010DOI Listing
March 2019
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Neuroprotective effect of astaxanthin on newborn rats exposed to prenatal maternal seizures.

Brain Res Bull 2019 Mar 22;148:63-69. Epub 2019 Mar 22.

Key Laboratory of Neurology of Hebei Province, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. Electronic address:

Maternal epilepsy during pregnancy is associated with an increased incidence of brain damage and cognitive deficits in offspring. Oxidative stress is believed to play a critical role in this process. Astaxanthin, a natural carotenoid and dietary supplement, possesses potent antioxidant properties. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.009DOI Listing
March 2019
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Alteration level of hippocampus BDNF expression and long-term potentiation upon microinjection of BRL15572 hydrochloride in a rat model of methamphetamine relapse.

Brain Res Bull 2019 Mar 20;148:18-24. Epub 2019 Mar 20.

Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Methamphetamine (METH) relapse affects the function of the serotonergic system, which this system important for synaptic plasticity and brain-derived neurotrophic factor (BDNF) level. While there is a clear distribution of serotonin receptors in the reward and memory areas but the function of 5-HT receptor isn't known. This article assessed effects of BRL15572 hydrochloride (5-HT receptor antagonist) on behavior, long-term potentiation (LTP), and BDNF level in reinstated METH-rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.008DOI Listing
March 2019
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2.718 Impact Factor

Olfactory deficit is associated with mitral cell dysfunction in the olfactory bulb of P301S tau transgenic mice.

Brain Res Bull 2019 Mar 19;148:34-45. Epub 2019 Mar 19.

Institute of Neuroscience and Anatomy, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:

Neurofibrillary tangles consisting of hyperphosphorylated tau (P-tau) are the neuropathological hallmark of Alzheimer's disease (AD), and olfaction disorder is an early symptom of AD. However, the link between P-tau aggregation and olfaction disorder remains unclear. In this study, the expression of P-tau in the olfactory bulb (OB), particularly in the mitral cell layer (MCL), external plexiform layer (EPL), and granule cell layer (GCL), of AD patients was found to be significantly higher than that in the OB of normal aging subjects, which suggested that these layers in the OB were susceptible to P-tau. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.006DOI Listing
March 2019
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2.718 Impact Factor

Intrahippocampal 5-HT receptor antagonist inhibits the improving effect of low-frequency stimulation on memory impairment in kindled rats.

Brain Res Bull 2019 Mar 19;148:109-117. Epub 2019 Mar 19.

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran; Institute for Brain Sciences and Cognition, Tarbiat Modares University, Tehran, Iran. Electronic address:

In addition to its anticonvulsant effect, low frequency stimulation (LFS) improves learning and memory in kindled animals. In the present study, the role of 5-HT receptors in mediating LFS' improving effect on spatial learning and memory was investigated in amygdala-kindled rats. Amygdala kindling was conducted in a semi-rapid kindling stimulations (12 stimulations per day) in male Wistar rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.007DOI Listing
March 2019
2.718 Impact Factor

A hyaluronan/methylcellulose-based hydrogel for local cell and biomolecule delivery to the central nervous system.

Brain Res Bull 2019 Mar 18;148:46-54. Epub 2019 Mar 18.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada; Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, Canada; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Canada; Department of Chemistry, University of Toronto, Toronto, Canada. Electronic address:

Regenerative medicine strategies rely on exogenous cell transplantation and/or endogenous cell stimulation. Biomaterials can help to increase the regenerative potential of cells and biomolecules by controlling transplanted cell fate and provide a local, sustained release of biomolecules. In this review, we describe the use of a hyaluronan/methylcellulose (HAMC)-based hydrogel as a delivery vehicle to the brain, spinal cord, and retina to promote cellular survival and tissue repair. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.005DOI Listing
March 2019
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The influence of microenvironment and extracellular matrix molecules in driving neural stem cell fate within biomaterials.

Brain Res Bull 2019 Mar 18;148:25-33. Epub 2019 Mar 18.

Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas, 78712, USA. Electronic address:

Transplantation of stem cells is a promising potential therapy for central nervous system disease and injury. The capacity for self-renewal, proliferation of progenitor cells, and multi-lineage potential underscores the need for controlling stem cell fate. Furthermore, transplantation within a hostile environment can lead to significant cell death and limited therapeutic potential. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.004DOI Listing
March 2019
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Modeling gut-brain interactions in zebrafish.

Brain Res Bull 2019 Mar 16;148:55-62. Epub 2019 Mar 16.

School of Pharmacy, Southwest University, Chongqing, China; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Ural Federal University, Ekaterinburg, Russia; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia; Granov Russian National Research Center of Radiology and Surgical Technologies, Ministry of Healthcare of Russian Federation, St. Petersburg, Russia. Electronic address:

Mounting clinical and experimental evidence suggests the gut-brain interplay as a novel important paradigm in translational neuroscience, including the critical role for gut microbiota in modulating brain development and behavior, as well as neuroimmune and neuroendocrine responses. Animal models are an indispensable tool in studying the central nervous system (CNS) disorders and their mechanisms. Recently, the zebrafish (Danio rerio) has become a powerful new model organism in neuroscience, including studying the gut-brain axis. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.003DOI Listing
March 2019
2 Reads

Inhibitory effects of peripheral administration of exendin-4 on food intake are attenuated by lesions of the central nucleus of amygdala.

Brain Res Bull 2019 Mar 9. Epub 2019 Mar 9.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, 98 XiWu Road, Xi'an, 710004, Shaanxi, PR China; Department of Orthodontics, Xi'an Jiaotong University School of Stomatology, 98# Xiwu Road, Xi'an, Shaanxi 710000, PR China. Electronic address:

The long-acting glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 suppresses food intake and decreases body weight. However, the mediating site(s) of action of the anorectic effects induced by peripheral administration of GLP-1R agonists are not well known. The present study investigated the effects of bilateral lesions of the central nucleus of the amygdala (CeA) on the suppression of chow and high-sucrose food intake by exendin-4 in rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.002DOI Listing
March 2019
4 Reads

Transcranial magnetic stimulation in subjects with phantom pain and non-painful phantom sensations: A systematic review.

Brain Res Bull 2019 Mar 9;148:1-9. Epub 2019 Mar 9.

Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, Salzburg, Austria; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Germany.

Several studies have applied transcranial magnetic stimulation (TMS) in the attempt to further explore the pathophysiological mechanisms of phantom-limb pain (PLP) and non-painful phantom sensations (PS). We performed a systematic review of available evidence of this emerging technology in this indication. We identified studies which report a reduced intracortical inhibition and increased intracortical facilitation in the hemisphere contralateral to the PLP. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.03.001DOI Listing
March 2019
1 Read
2.718 Impact Factor

Conductive polymers to modulate the post-stroke neural environment.

Brain Res Bull 2019 Mar 6;148:10-17. Epub 2019 Mar 6.

Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address:

Despite the prevalence of stroke, therapies to augment recovery remain limited. Here we focus on the use of conductive polymers for cell delivery, drug release, and electrical stimulation to optimize the post-stroke environment for neural recovery. Conductive polymers and their interactions with in vitro and in vivo neural systems are explored. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.015DOI Listing
March 2019
9 Reads

Ceasing exercise induces depression-like, anxiety-like, and impaired cognitive-like behaviours and altered hippocampal gene expression.

Brain Res Bull 2019 Feb 28. Epub 2019 Feb 28.

The University of Adelaide, School of Medicine, Discipline of Psychiatry, Adelaide, South Australia, Australia. Electronic address:

Background: Regular exercise can reduce depression-, anxiety-, and impaired cognitive-like behaviours, and upregulate hippocampal genes associated with neuroplasticity. However, the effects of ceasing exercise on depression-, anxiety-, and cognitive-like behaviours, and hippocampal gene expression remain unknown.

Methods: 12-week-old C57BL/6 mice (n = 12-16/group) were randomised to six months of exercise (exercise (EXC)), four months of exercise then two months of no exercise (exercise-cessation (EC)), or no-exercise control (CONT) until aged nine months. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.014DOI Listing
February 2019
2 Reads

SUMOylation participates in induction of ischemic tolerance in mice.

Brain Res Bull 2019 Apr 23;147:159-164. Epub 2019 Feb 23.

Department of Neurology, Tong Ren Hospital Shanghai Jiaotong University School of Medicine, Shanghai, 200336, China.

A group of proteins, small ubiquitin-like modifier (SUMO) proteins, has been shown to play a major role in rodent cerebral ischemia. Here, we proved that transient global cerebral ischemia induces a marked increase in protein sumo2/3 conjugation levels, we also find that global sumo2/3 conjugation is involved in ischemic tolerance in mice. Mice preconditioned by sublethal ischemia were less vulnerable to severe ischemia than non-preconditioned mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230173079
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http://dx.doi.org/10.1016/j.brainresbull.2019.02.012DOI Listing
April 2019
7 Reads

Co-exposure of metals and high fat diet causes aging like neuropathological changes in non-aged mice brain.

Brain Res Bull 2019 Apr 23;147:148-158. Epub 2019 Feb 23.

Neurobiology Laboratory, Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Sector H-12, Islamabad, 44000, Pakistan. Electronic address:

In recent decades, humans' exposure to metals have increased due to industrialization and socioeconomic trends have caused increased high fat diet (HFD) consumption. Concurrently, metals and HFD are risk factors for health, and in particular, the cognitive impairment. The aim of this study was to evaluate the effect of metals and HFD treatment on neuropathological changes in young mice brain, and compare with untreated young mice (8-11 weeks = 2-3 months) and aged mice (12 months). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.013DOI Listing

The role of adenosine and P2Y receptors expressed by multiple cell types in pain transmission.

Brain Res Bull 2019 Feb 21. Epub 2019 Feb 21.

Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission, Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti, 9, 20133, Milan, Italy. Electronic address:

The role of extracellular nucleotides and nucleosides as signaling molecules in cell-to-cell communication has now been clearly established. This is particularly true in the central and peripheral nervous system, where purines and pyrimidines are involved in both physiological and pathological interactions between neurons and surrounding glial cells. It can be thus foreseen that the purinergic system could represent a new potential target for the development of effective analgesics, also through the normalization of neuronal functions and the inhibition of glial cell activation. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.011DOI Listing
February 2019
2 Reads

GABAergic mediation of hippocampal theta rhythm induced by stimulation of the vagal nerve.

Brain Res Bull 2019 Apr 20;147:110-123. Epub 2019 Feb 20.

Department of Neurobiology, Faculty of Biology and Environmental Protection, The University of Lodz, Pomorska St. No 141/143, 90-236, Lodz, Poland. Electronic address:

The key question to be answered in the present study was whether the medial septal GABAergic receptors are engaged in the pharmacological profile of the hippocampal formation (HPC) theta rhythm induced by vagal nerve stimulation (VNS). It was demonstrated that the medial septal microinfusion of GABA and GABA agonists (muscimol and baclofen) resulted in a progressive reduction of the power of VNS-induced theta. The medial septal microinfusion of GABA and GABA antagonists (bicuculline and 2-OH saclofen) resulted in the generation of VNS-induced theta with increased power. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.010DOI Listing
April 2019
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Effects of long non-coding RNA uc.48+ on pain transmission in trigeminal neuralgia.

Brain Res Bull 2019 Apr 14;147:92-100. Epub 2019 Feb 14.

Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China. Electronic address:

Trigeminal neuralgia (TN) is the most common neuropathic pain in the facial area, for which the effective therapy is unavailable. Long non-coding RNA (lncRNA) such as lncRNA uc.48+ is involved in diabetic neuropathic pain and may affect purinergic signaling in ganglia of diabetic rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.009DOI Listing
April 2019
3 Reads

Effects of sodium nitroprusside in the acute dizocilpine (MK-801) animal model of schizophrenia.

Brain Res Bull 2019 Apr 14;147:140-147. Epub 2019 Feb 14.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No.388, Jianshe Middle Road, Xinxiang, 453002, Henan, People's Republic of China; Henan Key Lab of Biological Psychiatry of Xinxiang Medical University, Xinxiang, People's Republic of China; International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, People's Republic of China. Electronic address:

Schizophrenia treatment remains a major challenge, especially the associated cognitive impairments, as these are not consistently alleviated by conventional antipsychotics. Recent animal and clinical studies suggest that the nitric oxide (NO) donor sodium nitroprusside (SNP) reduces the psychiatric symptoms and cognitive deficits of schizophrenia. The present study was designed to investigate the efficacy of SNP against schizophrenia-like behavioral and cognitive deficits in the dizocilpine (MK-801) rat model. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.008DOI Listing
April 2019
3 Reads

Cumulative multiple early life hits- a potent threat leading to neurological disorders.

Brain Res Bull 2019 Apr 13;147:58-68. Epub 2019 Feb 13.

School of Studies in Neuroscience, Jiwaji University, Gwalior, India; School of Studies in Zoology, Jiwaji University, Gwalior, India. Electronic address:

Early life Stress is a worldwide concern linked with development of later life neurological disorders. Early developmental age is sensitive to many prominent environmental insults like malnourishment, immune inflammation, abuse, maternal separation, alcohol and drugs. Hence, an individual during an early age encounters more than one simultaneous stressor that leads to impairment of cognitive and behavioral abilities, a symptom common to most of the neurological disorders. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.005DOI Listing
April 2019
2 Reads

Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with Adenosine A receptor agonist.

Brain Res Bull 2019 Apr 13;147:47-57. Epub 2019 Feb 13.

Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Delhi, India. Electronic address:

Hearing loss and cognitive decline are commonly associated with aging and morbidity. Present clinical interest lies in whether peripheral hearing loss promotes cognitive decline and if prophylaxis with selective adenosine receptor agonist CGS21680 effectively mitigates the adverse effects. In the current study, male Sprague Dawley rats weighing 200-250 g m were randomly allocated into three groups: Group 1) rats exposed to 100 dB SPL white noise, 2 h a day for 15 consecutive days, 2) rats supplemented with an adenosine receptor agonist, CGS21680 at 100 μg/kg/day prior to noise exposure and 3) unexposed control rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.006DOI Listing
April 2019
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Corrigendum to "Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis" [Brain Research Bulletin 140 (2018) 318-333].

Brain Res Bull 2019 Mar;146:327

Department of Physiology and biomedical engineering,Mayo Clinic, Rochester, MN,USA; School of Biomedical sciences, The University of Queensland,St Lucia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.007DOI Listing
March 2019
2 Reads

Paternal exposure to morphine during adolescence induces reward-resistant phenotype to morphine in male offspring.

Brain Res Bull 2019 Apr 12;147:124-132. Epub 2019 Feb 12.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The developing brain is extremely sensitive to drugs during adolescence. The devastating impacts of opioid abuse in this critical period not only do involve individuals but also are witnessed in the subsequent generations. Therefore, what is recognized as the population susceptible to the effects of opioid abuse could be much greater in number. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.004DOI Listing
April 2019
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Brainstem reflex excitability after high-frequency repetitive transcranial magnetic stimulation in healthy and spinal cord injury subjects.

Brain Res Bull 2019 Apr 12;147:86-91. Epub 2019 Feb 12.

Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, 089M6, Badalona, Barcelona, Spain; Univ Autonoma de Barcelona, 08M93, Bellaterra, Cerdanyola del Vallès, Spain; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.

Background: The excitability of brainstem interneuronal circuits is partly under control from descending inputs. Since high frequency repetitive transcranial magnetic stimulation (rTMS) modulates cortical output, we hypothesized that it will also modulate brainstem functions. Such modulation may be different in healthy subjects than in subjects with spinal cord injury (SCI), submitted to an altered integration of body afferent inputs. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.002DOI Listing
April 2019
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Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.

Brain Res Bull 2019 Apr 12;147:36-46. Epub 2019 Feb 12.

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, India; CNS Pharmacology, Conscience Research, Delhi, India. Electronic address:

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with two major behavioral symptoms i.e. repetitive behavior and social-communication impairment. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.003DOI Listing
April 2019
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2.718 Impact Factor

Similarity and dissimilarity in antinociceptive effects of dipeptidyl-peptidase 4 inhibitors, Diprotin A and vildagliptin in rat inflammatory pain models following spinal administration.

Brain Res Bull 2019 Apr 7;147:78-85. Epub 2019 Feb 7.

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, P.O. Box 370, H-1445, Budapest, Hungary. Electronic address:

Dipeptidyl-peptidase 4 (DPP4) enzyme is involved in the degradation of many biologically active peptides including opioids. Its role in pain transmission is poorly elucidated. Recently we reported on the spinal antihyperalgesic effects of DPP4 inhibitors, Ile-Pro-Ile (Diprotin A) and vildagliptin in carrageenan-evoked acute inflammatory pain in rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.001DOI Listing

Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice.

Brain Res Bull 2019 Apr 6;147:174-182. Epub 2019 Feb 6.

Iranian Centre of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The role of endoplasmic reticulum (ER) stress has been proposed in several neurodegenerative and autoimmune diseases and may contribute to neural apoptosis. The complex role of ER stress-mediated apoptosis introduces a novel angle on multiple sclerosis (MS) research. Nevertheless, the mechanisms through which ER stress intermediates apoptosis are not entirely understood. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.020DOI Listing
April 2019
5 Reads

Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.

Brain Res Bull 2019 Apr 7;147:22-35. Epub 2019 Feb 7.

Institute of Information and Communication Technologies, BAS, Sofia, Bulgaria.

Recently, we have reported that while agomelatine (Ago) is unable to prevent development of epilepsy it exerts a strong neuroprotective and anti-inflammatory response in the KA post-status epilepticus (SE) rat model. In the present study, we aimed to explore whether the brain-derived neurotrophic factor (BDNF) in the hippocampus is involved in the neuroprotective effect of Ago against the KA-induced SE and epileptiform activity four months later in rats. Lacosamide (LCM) was used as a positive control. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.017DOI Listing
April 2019
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The mechanism of GLT-1 mediating cerebral ischemic injury depends on the activation of p38 MAPK.

Brain Res Bull 2019 Apr 4;147:1-13. Epub 2019 Feb 4.

Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China. Electronic address:

The previous studies have shown that glial glutamate transporter-1 (GLT-1) participates in cerebral ischemic injury in rats. However, the mechanism involved remains to be elucidated. This study was undertaken to investigate whether p38 MAPK was involved in regulating GLT-1 in the process. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.028DOI Listing
April 2019
2 Reads
2.718 Impact Factor

Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders.

Brain Res Bull 2019 Feb 2. Epub 2019 Feb 2.

Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary. Electronic address:

The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y, , , , and ) regulate neuronal/neuroglial developmental processes, such as proliferation, differentiation, migration of neuronal precursors, and neurite outgrowth. However, only a few of these subtypes (P2X2, P2X3, P2X4, P2X7, P2Y, and P2Y) have been investigated in the context of neurodevelopmental psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.030DOI Listing
February 2019
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Nucleotides regulate the common molecular mechanisms that underlie neurodegenerative diseases; Therapeutic implications.

Brain Res Bull 2019 Feb 2. Epub 2019 Feb 2.

Department of Biochemistry and Molecular Biology, Veterinary School, Complutense University of Madrid, Avda. Puerta de Hierro S/N, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, IdISSC, Madrid, Spain. Electronic address:

Neurodegenerative diseases (ND) are a heterogeneous group of neurological disorders characterized by a progressive loss of neuronal function which results in neuronal death. Although a specific toxic factor has been identified for each ND, all of them share common pathological molecular mechanisms favouring the disease development. In the final stages of ND, patients become unable to take care of themselves and decline to a total functional incapacitation that leads to their death. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.031DOI Listing
February 2019
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Chronic insulinopenia/hyperglycemia decreases cannabinoid CB receptor density and impairs glucose uptake in the mouse forebrain.

Brain Res Bull 2019 Apr 2;147:101-109. Epub 2019 Feb 2.

CNC, Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504 Coimbra, Portugal; Institute for Interdisciplinary Research, University of Coimbra, 3030-789 Coimbra, Portugal. Electronic address:

Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis via convergent signaling pathways that are impacted by diabetes. Here we asked how glucose metabolism and important facets of insulin signaling are affected in the forebrain of cannabinoid CB receptor knockout mice (CBR-KO) and their wild-type (WT) littermates, seven weeks after the induction of insulinopenia/hyperglycemia (diabetes) with intraperitoneal streptozotocin injection. Sham-injected animals served as control. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420377PMC

Purinergic signaling in the organ of Corti: Potential therapeutic targets of sensorineural hearing losses.

Brain Res Bull 2019 Feb 2. Epub 2019 Feb 2.

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary; Department of Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary. Electronic address:

Purinergic signaling is deeply involved in the development, functions and protective mechanisms of the cochlea. Release of ATP and activation of purinergic receptors on sensory and supporting/epithelial cells play a substantial role in cochlear (patho)physiology. Both the ionotropic P2X and the metabotropic P2Y receptors are widely distributed on the inner and outer hair cells as well as on the different supporting cells in the organ of Corti and on other epithelial cells in the scala media. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.029DOI Listing
February 2019
2 Reads