8,637 results match your criteria Brain Research Bulletin[Journal]


Effects of long non-coding RNA uc.48+ on pain transmission in trigeminal neuralgia.

Brain Res Bull 2019 Feb 14. Epub 2019 Feb 14.

Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China. Electronic address:

Trigeminal neuralgia (TN) is the most common neuropathic pain in the facial area, for which the effective therapy is unavailable. Long non-coding RNA (lncRNA) such as lncRNA uc.48+ is involved in diabetic neuropathic pain and may affect purinergic signaling in ganglia of diabetic rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.009DOI Listing
February 2019

Effects of sodium nitroprusside in the acute dizocilpine (MK-801) animal model of schizophrenia.

Brain Res Bull 2019 Feb 14. Epub 2019 Feb 14.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, No.388, Jianshe Middle Road, Xinxiang, 453002, Henan, People's Republic of China; Henan Key Lab of Biological Psychiatry of Xinxiang Medical University, Xinxiang, People's Republic of China; International Joint Research Laboratory for Psychiatry and Neuroscience of Henan, Xinxiang, People's Republic of China. Electronic address:

Schizophrenia treatment remains a major challenge, especially the associated cognitive impairments, as these are not consistently alleviated by conventional antipsychotics. Recent animal and clinical studies suggest that the nitric oxide (NO) donor sodium nitroprusside (SNP) reduces the psychiatric symptoms and cognitive deficits of schizophrenia.The present study was designed to investigate the efficacy of SNP against schizophrenia-like behavioral and cognitive deficits in the dizocilpine (MK-801) rat model. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.008DOI Listing
February 2019
2 Reads

Cumulative multiple early life hits- a potent threat leading to neurological disorders.

Brain Res Bull 2019 Feb 13;147:58-68. Epub 2019 Feb 13.

School of Studies in Neuroscience, Jiwaji University, Gwalior, India; School of Studies in Zoology, Jiwaji University, Gwalior, India. Electronic address:

Early life Stress is a worldwide concern linked with development of later life neurological disorders. Early developmental age is sensitive to many prominent environmental insults like malnourishment, immune inflammation, abuse, maternal separation, alcohol and drugs. Hence, an individual during an early age encounters more than one simultaneous stressor that leads to impairment of cognitive and behavioral abilities, a symptom common to most of the neurological disorders. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.005DOI Listing
February 2019
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Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with Adenosine A receptor agonist.

Brain Res Bull 2019 Feb 13;147:47-57. Epub 2019 Feb 13.

Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Delhi, India. Electronic address:

Hearing loss and cognitive decline are commonly associated with aging and morbidity. Present clinical interest lies in whether peripheral hearing loss promotes cognitive decline and if prophylaxis with selective adenosine receptor agonist CGS21680 effectively mitigates the adverse effects. In the current study, male Sprague Dawley rats weighing 200-250 g m were randomly allocated into three groups: Group 1) rats exposed to 100 dB SPL white noise, 2 h a day for 15 consecutive days, 2) rats supplemented with an adenosine receptor agonist, CGS21680 at 100 μg/kg/day prior to noise exposure and 3) unexposed control rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.006DOI Listing
February 2019

Corrigendum to "Driven to decay: Excitability and synaptic abnormalities in amyotrophic lateral sclerosis" [Brain Research Bulletin 140 (2018) 318-333].

Brain Res Bull 2019 Mar;146:327

Department of Physiology and biomedical engineering,Mayo Clinic, Rochester, MN,USA; School of Biomedical sciences, The University of Queensland,St Lucia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.007DOI Listing
March 2019
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Paternal exposure to morphine during adolescence induces reward-resistance phenotype to morphine in male offspring.

Brain Res Bull 2019 Feb 12. Epub 2019 Feb 12.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The developing brain is extremely sensitive to drugs during adolescence. The devastating impacts of opioid abuse in this critical period not only do involve individuals but also are witnessed in the subsequent generations. Therefore, what is recognized as the population susceptible to the effects of opioid abuse could be much greater in number. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.004DOI Listing
February 2019
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BRAINSTEM REFLEX EXCITABILITY AFTER HIGH-FREQUENCY REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION IN HEALTHY AND SPINAL CORD INJURY SUBJECTS.

Brain Res Bull 2019 Feb 12. Epub 2019 Feb 12.

Institut Guttmann, Institut Universitari de Neurorehabilitació adscrit a la UAB, 089M6 Badalona, Barcelona, Spain; Univ Autonoma de Barcelona, 08M93 Bellaterra (Cerdanyola del Vallès), Spain; Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Badalona, Barcelona, Spain.

Background: The excitability of brainstem interneuronal circuits is partly under control from descending inputs. Since high frequency repetitive transcranial magnetic stimulation (rTMS) modulates cortical output, we hypothesized that it will also modulate brainstem functions. Such modulation may be different in healthy subjects than in subjects with spinal cord injury (SCI), submitted to an altered integration of body afferent inputs. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.002DOI Listing
February 2019

Benefits of Fenofibrate in prenatal valproic acid-induced autism spectrum disorder related phenotype in rats.

Brain Res Bull 2019 Feb 12;147:36-46. Epub 2019 Feb 12.

Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, India; CNS Pharmacology, Conscience Research, Delhi, India. Electronic address:

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder with two major behavioral symptoms i.e. repetitive behavior and social-communication impairment. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.003DOI Listing
February 2019
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Similarity and dissimilarity in antinociceptive effects of dipeptidyl-peptidase 4 inhibitors, Diprotin A and vildagliptin in rat inflammatory pain models following spinal administration.

Brain Res Bull 2019 Feb 7. Epub 2019 Feb 7.

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, P.O. Box 370, H-1445 Budapest, Hungary. Electronic address:

Dipeptidyl-peptidase 4 (DPP4) enzyme is involved in the degradation of many biologically active peptides including opioids. Its role in pain transmission is poorly elucidated. Recently we reported on the spinal antihyperalgesic effects of DPP4 inhibitors, Ile-Pro-Ile (Diprotin A) and vildagliptin in carrageenan-evoked acute inflammatory pain in rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.001DOI Listing
February 2019

Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice.

Brain Res Bull 2019 Feb 6. Epub 2019 Feb 6.

Iranian Centre of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

The role of endoplasmic reticulum (ER) stress has been proposed in several neurodegenerative and autoimmune diseases and may contribute to neural apoptosis. The complex role of ER stress-mediated apoptosis introduces a novel angle on multiple sclerosis (MS) research. Nevertheless, the mechanisms through which ER stress intermediates apoptosis are not entirely understood. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.020DOI Listing
February 2019
1 Read

Agomelatine alleviates neuronal loss through BDNF signaling in the post-status epilepticus model induced by kainic acid in rat.

Brain Res Bull 2019 Feb 7;147:22-35. Epub 2019 Feb 7.

Institute of Information and Communication Technologies, BAS, Sofia, Bulgaria.

Recently, we have reported that while agomelatine (Ago) is unable to prevent development of epilepsy it exerts a strong neuroprotective and anti-inflammatory response in the KA post-status epilepticus (SE) rat model. In the present study, we aimed to explore whether the brain-derived neurotrophic factor (BDNF) in the hippocampus is involved in the neuroprotective effect of Ago against the KA-induced SE and epileptiform activity four months later in rats. Lacosamide (LCM) was used as a positive control. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.017DOI Listing
February 2019
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The mechanism of GLT-1 mediating cerebral ischemic injury depends on the activation of p38 MAPK.

Brain Res Bull 2019 Feb 4;147:1-13. Epub 2019 Feb 4.

Department of Pathophysiology, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, People's Republic of China. Electronic address:

The previous studies have shown that glial glutamate transporter-1 (GLT-1) participates in cerebral ischemic injury in rats. However, the mechanism involved remains to be elucidated. This study was undertaken to investigate whether p38 MAPK was involved in regulating GLT-1 in the process. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.028DOI Listing
February 2019
2.718 Impact Factor

Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders.

Brain Res Bull 2019 Feb 2. Epub 2019 Feb 2.

Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary. Electronic address:

The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2 × 1, 2, 3, 4, 6, and 7, and P2Y, , , , and ) regulate neuronal/neuroglial developmental processes, such as proliferation, differentiation, migration of neuronal precursors, and neurite outgrowth. However, only a few of these subtypes (P2 × 2, P2 × 3, P2 × 4, P2 × 7, P2Y, and P2Y) have been investigated in the context of neurodevelopmental psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.030DOI Listing
February 2019
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Nucleotides regulate the common molecular mechanisms that underlie neurodegenerative diseases; Therapeutic implications.

Brain Res Bull 2019 Feb 2. Epub 2019 Feb 2.

Department of Biochemistry and Molecular Biology, Veterinary School, Complutense University of Madrid, Avda. Puerta de Hierro S/N, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, IdISSC, Madrid, Spain. Electronic address:

Neurodegenerative diseases (ND) are a heterogeneous group of neurological disorders characterized by a progressive loss of neuronal function which results in neuronal death. Although a specific toxic factor has been identified for each ND, all of them share common pathological molecular mechanisms favouring the disease development. In the final stages of ND, patients become unable to take care of themselves and decline to a total functional incapacitation that leads to their death. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.031DOI Listing
February 2019

Chronic insulinopenia/hyperglycemia decrease cannabinoid CB receptor density and impair glucose uptake in the mouse forebrain.

Brain Res Bull 2019 Feb 2. Epub 2019 Feb 2.

CNC, Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, 3004-504, Coimbra, Portugal; Institute for Interdisciplinary Research, University of Coimbra, 3030-789, Coimbra, Portugal. Electronic address:

Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis via convergent signaling pathways that are impacted by diabetes. Here we asked how glucose metabolism and important facets of insulin signaling are affected in the forebrain of cannabinoid CB receptor knockout mice (CBR-KO) and their wild-type (WT) littermates, seven weeks after the induction of insulinopenia/hyperglycemia (diabetes) with intraperitoneal streptozotocin injection. Sham-injected animals served as control. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.024DOI Listing
February 2019

Purinergic signaling in the organ of Corti: potential therapeutic targets of sensorineural hearing losses.

Brain Res Bull 2019 Feb 2. Epub 2019 Feb 2.

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary. Electronic address:

Purinergic signaling is deeply involved in the development, functions and protective mechanisms of the cochlea. Release of ATP and activation of purinergic receptors on sensory and supporting/epithelial cells play a substantial role in cochlear (patho)physiology. Both the ionotropic P2X and the metabotropic P2Y receptors are widely distributed on the inner and outer hair cells as well as on the different supporting cells in the organ of Corti and on other epithelial cells in the scala media. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.029DOI Listing
February 2019
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Investigation of protective effects of coenzyme Q10 on impaired synaptic plasticity in a male rat model of Alzheimer's disease.

Brain Res Bull 2019 Feb 2;147:14-21. Epub 2019 Feb 2.

Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Oxidative stress plays a key role in contributing to β-amyloid (Aβ) deposition in Alzheimer's disease (AD). Coenzyme Q10 (Q10) is a powerful antioxidant that buffers the potential adverse consequences of free radicals. In this study, we investigated the neuroprotective effects of Q10 on Aβ-induced impairment in hippocampal long-term potentiation (LTP), a widely researched model of synaptic plasticity, which occurs during learning and memory, in a rat model of AD. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.025DOI Listing
February 2019
3 Reads

MCC950 attenuated early brain injury by suppressing NLRP3 inflammasome after experimental SAH in rats.

Brain Res Bull 2019 Mar 1;146:320-326. Epub 2019 Feb 1.

Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Electronic address:

Nucleotide oligomerization domain(NOD)-like receptor protein-3(NLRP3) inflammasome is a multiprotein complex, which results in the inflammatory response in early brain injury(EBI) after subarachnoid hemorrhage(SAH). MCC950, a specific NLRP3 inhibitor, plays neuroprotective effects in several central nervous system diseases. However, the role of MCC950 in SAH remains elusive. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.027DOI Listing
March 2019
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Acid sphingomyelinase controls dopamine activity and responses to appetitive stimuli in mice.

Brain Res Bull 2019 Mar 1;146:310-319. Epub 2019 Feb 1.

Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany. Electronic address:

Alcohol use disorder and depression show a high comorbidity at clinical level with no treatment available selectively for this condition. A hyperfunction of acid sphingomyelinase (ASM) and resulting ceramide overload were recently identified as one pathway into this comorbidity. Here we analyzed the involvement of ASM, one of the main enzymes involved in ceramide synthesis, in the molecular control of monoaminergic systems in their basal activity and in response to pharmacological and natural reinforcers. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.026DOI Listing
March 2019
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α-Methyl-prednisolone normalizes the PKC mediated brain angiogenesis in dystrophic mdx mice.

Brain Res Bull 2019 Jan 31;147:69-77. Epub 2019 Jan 31.

Department of Basic Medical Sciences, Neurosciences and Sensory Organs, Section of Human Anatomy and Histology, University of Bari Medical School Bari, University of Bari, Italy. Electronic address:

A fraction of patients affected by Duchenne Muscular Dystrophy (DMD) shows mental disability as a consequence of neuronal and metabolic alteration. In this study, we evaluated the effect of α-methyl-prednisolone (PDN) on the expression of the angiogenic marker HIF1α, VEGFA and VEGFR-2 (FLK1) in correlation with PKC expression in the brain of mdx mouse, an experimental model of DMD. We demonstrated that HIF1α, VEGFA and FLK1 are overexpressed in the brain of dystrophic mdx mice in parallel with an increase of PKC expression and reduction of the tight junctions Occludin leading to altered angiogenesis. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.023DOI Listing
January 2019

Ro41-5253, a selective antagonist of retinoic acid receptor α, ameliorates chronic unpredictable mild stress-induced depressive-like behaviors in rats: Involvement of regulating HPA axis and improving hippocampal neuronal deficits.

Brain Res Bull 2019 Mar 31;146:302-309. Epub 2019 Jan 31.

School of Pharmacy, Anhui Medical University, Hefei, 230032, Anhui, China.

Accumulating reports have highlighted an association between excess retinoids and depression development. Retinoic acid receptor α (RARα) is implicated in the activation of hypothalamus-pituitary-adrenal (HPA) axis and closely involved in the etiology of depression, suggesting it might be a novel target of antidepressant. This study investigated the antidepressant potential of Ro41-5253 (a selective RARα antagonist) and related mechanisms using a depression rat model imitated by social isolation and chronic unpredicted mild stress (CUMS). Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.022DOI Listing

Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice.

Brain Res Bull 2019 Mar 25;146:279-286. Epub 2019 Jan 25.

Laboratório de Fisiologia, Departamento de Ciências Básicas em Saúde, Faculdade de Medicina, Universidade Federal de Mato Grosso, Boa Esperança, 78060900, Cuiabá, MT, Brazil. Electronic address:

Clinical and pre-clinical evidences indicate an association between inflammation and depression since increased levels of pro-inflammatory cytokines are associated with depression-related symptoms. Atorvastatin is a cholesterol-lowering statin that possesses pleiotropic effects including neuroprotective and antidepressant actions. However, the putative neuroprotective effect of atorvastatin treatment in the acute inflammation mice model of depressive-like behaviour has not been investigated. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.018DOI Listing

Neuroprotection by urate on the mutant hSOD1-related cellular and Drosophila models of amyotrophic lateral sclerosis: Implication for GSH synthesis via activating Akt/GSK3β/Nrf2/GCLC pathways.

Brain Res Bull 2019 Mar 26;146:287-301. Epub 2019 Jan 26.

Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, 150001, PR China. Electronic address:

Oxidative stress has been considered as a principal mechanism of motor neuron death in amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease which could be caused by dominant mutations in an antioxidant enzyme superoxide dismutase-1 (SOD1). The aim of the present study was to investigate the potential neuroprotective effects and mechanisms of urate, an important endogenous antioxidant and a biomarker of favorable ALS progression rates, in the mutant human SOD1-related cellular and Drosophila models of ALS. Our results showed that urate treatment provided neuroprotective effects as confirmed by enhanced survival, attenuated motor impairments, reduced oxidative damage and increased antioxidant defense in hSOD1-G85R-expressing Drosophila models of ALS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183060
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.019DOI Listing
March 2019
2 Reads

Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms.

Brain Res Bull 2019 Jan 18. Epub 2019 Jan 18.

Department of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Hungary and János Szentágothai Research Centre, Centre for Neuroscience, University of Pécs, Hungary. Electronic address:

The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates the tachykinin NK1 receptor, but with binding site and signaling pathways different from Substance P (SP). NK1 receptor is involved in nociception, but our earlier data showed that it has no role in chronic neuropathic hyperalgesia, similarly to SP. Furthermore, NK1 antagonists failed in clinical trials as analgesics due to still unknown reasons. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.015DOI Listing
January 2019
1 Read

Cannabinoid receptor as a potential therapeutic target for Parkinson's Disease.

Brain Res Bull 2019 Mar 18;146:244-252. Epub 2019 Jan 18.

Cellular and Molecular Therapeutics Laboratory, Centre for Biomaterials, Cellular and Molecular Theranostics, Vellore Institute of Technology (VIT), Vellore, 632014, Tamil Nadu, India. Electronic address:

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, characterized by the loss of dopaminergic neurons from substantia nigra pars compacta of basal ganglia caused due to gene mutation, misfolded protein aggregation, reactive oxygen species generation and inflammatory stress. Degeneration of dopaminergic neurons results in muscle stiffness, uncoordinated body movements, sleep disturbance, fatigue, amnesia and impaired voice. Currently, levodopa (L-DOPA) administration is the most widely used therapy for PD. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.016DOI Listing
March 2019
5 Reads

Effects of maternal exposure to nonylphenol on learning and memory in offspring involve inhibition of BDNF-PI3K/Akt signaling.

Brain Res Bull 2019 Mar 17;146:270-278. Epub 2019 Jan 17.

Department of Occupational and Environmental Health, School of Public Health, China Medical University, PR China. Electronic address:

Nonylphenol (NP), a global environmental pollutant, has been found to result in impairments of neurodevelopment. However, effects of maternal exposure to NP on learning and memory and the potential mechanisms are largely unexplored. Thus, we treated dams with NP during gestation and lactation to study its effect on learning and memory in offspring. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183066
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.014DOI Listing
March 2019
3 Reads

ATP release during seizures - A critical evaluation of the evidence.

Brain Res Bull 2019 Jan 17. Epub 2019 Jan 17.

Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, D02YN77, Dublin, Ireland.

That adenosine 5' triphosphate (ATP) functions as an extracellular signaling molecule has been established since the 1970s. Ubiquitous throughout the body as the principal molecular store of intracellular energy, ATP has a short extracellular half-life and is difficult to measure directly. Extracellular ATP concentrations are dependent both on the rate of cellular release and of enzymatic degradation. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.021DOI Listing
January 2019
2 Reads

Modulation of sphingosine-1-phosphate receptor by FTY720 contributes in improvement of hepatic encephalopathy induced by bile duct ligation.

Brain Res Bull 2019 Mar 17;146:253-269. Epub 2019 Jan 17.

Department of Physiology, The Medical School, Shiraz University of Medical Sciences, Shiraz, 71365-1689, Iran; Histomorphometry and Stereology Research Centre, Shiraz University of Medical Sciences, Shiraz, 71365-1689, Iran. Electronic address:

Hepatic encephalopathy (HE) is a complex neuropsychiatric disorder, which is associated with memory loss and behavioral abnormalities. The cellular and molecular mechanisms that led to hippocampal dysfunction in bile duct ligation (BDL)-induced HE and neuroprotective mechanisms of FTY720 administration were evaluated using whole-cell patch clamp, field-potential recording, western blot, stereology and behavioral experiments. The animals were divided into 4 groups of control (n = 24), sham (n = 21), BDL + V (n = 21) and BDL + FTY720 (n = 20), each having three subgroups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183079
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.012DOI Listing
March 2019
6 Reads
2.718 Impact Factor

P2X3 receptors are transducers of sensory signals.

Authors:
Elsa Fabbretti

Brain Res Bull 2019 Jan 17. Epub 2019 Jan 17.

Department of Life Science, University of Trieste, via Giorgieri 5, 34127, Trieste, Italy. Electronic address:

Peripheral stimuli are transduced by specific receptors expressed by sensory neurons and are further processed in the dorsal horn of spinal cord before to be transmitted to the brain. While relative few receptor subtypes mediate the initial depolarisation of sensory neurons, an impressive number of molecules and ion channels integrate these inputs into coded signals. Soluble mediators and ambient conditions further shape these processes, potentially triggering peripheral and central sensitisation, or sensory downregulation. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.020DOI Listing
January 2019
1 Read

Effect of acute and chronic restraint stress on electrical activity of prefrontal cortex neurons in the reinstatement of extinguished methamphetamine-induced conditioned place preference: An electrophysiological study.

Brain Res Bull 2019 Mar 17;146:237-243. Epub 2019 Jan 17.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, 19615-1178, Tehran, Iran. Electronic address:

Increased vulnerability to drug abuse has been observed after exposure to stress and the prefrontal cortex (PFC) plays a major role in the control of the stress response and reward pathway. The current study was conducted to clarify the effects of acute and chronic restraint stress on PFC neural activity during the reinstatement of methamphetamine (METH)-induced conditioned place preference (CPP) in rats. Following the establishment of CPP (METH 0. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.013DOI Listing
March 2019
2 Reads

Cerebral malaria.

Brain Res Bull 2019 Feb 15;145:53-58. Epub 2019 Jan 15.

Department of Parasitology, National Institute of Biomedical Research, BP 1187 Kinshasa, Gombe, Democratic Republic of the Congo; Department of Tropical Medicine, School of Medicine, University of Kinshasa, BP 834 Kinshasa XI, Democratic Republic of the Congo. Electronic address:

Malaria remains of significant public health concern under the tropics, causing millions of deaths annually. The disease is caused by protozoans of the Plasmodium genus, of which harbors several distinct species. Human infection occurs during the blood meal of an infected female mosquito belonging to the Anopheles genus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183032
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.010DOI Listing
February 2019
16 Reads

The neural response to deep brain stimulation of the anterior nucleus of the thalamus: a MEMRI and c-Fos study.

Brain Res Bull 2019 Jan 15. Epub 2019 Jan 15.

Department of Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; Epilepsy Center, Neurological Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Background: Deep brain stimulation (DBS) refers to the delivery of electric current to specific deep brain structures through implanted electrodes. Recently approved for use in United States, DBS to the anterior nucleus of thalamus (ANT) is a safe and effective alternative treatment for medically refractory seizures. Despite the anti-seizure effects of ANT DBS, preclinical and clinical studies have failed to demonstrate it actions at a whole brain level. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.011DOI Listing
January 2019
3 Reads

Viral infections of the central nervous system in Africa.

Brain Res Bull 2019 Feb 15;145:2-17. Epub 2019 Jan 15.

Neuroscience, USUHS, Bethesda, MD, 20814, USA. Electronic address:

Viral infections are a major cause of human central nervous system infection, and may be associated with significant mortality, and long-term sequelae. In Africa, the lack of effective therapies, limited diagnostic and human resource facilities are especially in dire need. Most viruses that affect the central nervous system are opportunistic or accidental pathogens. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.019DOI Listing
February 2019
16 Reads

Cognitive and anxiety-like impairments accompanied by serotonergic ultrastructural and immunohistochemical alterations in early stages of parkinsonism.

Brain Res Bull 2019 Mar 11;146:213-223. Epub 2019 Jan 11.

Behavioral and Evolutionary Neurobiology Laboratory, Department of Bioscience, Federal University of Sergipe, Itabaiana, SE, Brazil. Electronic address:

Parkinson's disease (PD) is mostly known as a dopamine deficiency syndrome due the structural and functional changes in striatal projection neurons. However, studies have considered this pathology as a multi-systemic disease in which the neurodegenerative process extends beyond the dopaminergic system. Therefore, the purpose of the present study was to investigate the morphological and immunohistochemical changes associated with behavioral and cognitive alterations in a model of parkinsonism induced by low dose of reserpine. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183079
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.009DOI Listing
March 2019
6 Reads

Functional and pharmacological analysis of agmatine administration in different cerebral ischemia animal models.

Brain Res Bull 2019 Mar 11;146:201-212. Epub 2019 Jan 11.

Faculty of Biology, University of Belgrade, Serbia. Electronic address:

Agmatine (AgM, 100 mg/kg i.p.) effect was tested in parallel at two animal models of cerebral ischemia - rat MCAO model (60'/24 h, 60'/48 h, 90'/24 h, 90'/48 h) and gerbil global ischemia (10') model, administrated 5 min after reperfusion. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.005DOI Listing
March 2019
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Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model.

Brain Res Bull 2019 Mar 9;146:192-200. Epub 2019 Jan 9.

Department of Pain Management, Fujian Key Laboratory of Geriatrics, Fujian Provincial Hospital, Provincial Clinic College of Fujian Medical University, Fuzhou, Fujian, China. Electronic address:

Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG), which produces remarkable analgesia through high-frequency electromagnetic energy, has become a main therapy for chronic neuropathic pain. The chronic neuropathic pain in patients is frequently accompanied by depression. However, the underlying neurophysiological mechanisms of the treatment of PRF on DRG for the neuropathic pain-induced depression remain unclear. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.008DOI Listing
March 2019
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Investigating KYNA production and kynurenergic manipulation on acute mouse brain slice preparations.

Brain Res Bull 2019 Mar 9;146:185-191. Epub 2019 Jan 9.

Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Közép Fasor 52., Szeged, 6726, Hungary. Electronic address:

Manipulation of kynurenic acid (KYNA) level through kynurenine aminotransferase-2 (KAT-2) inhibition with the aim of therapy in neuro-psychiatric diseses has been the subject of extensive recent research. Although mouse models are of particular importance, neither the basic mechanism of KYNA production and release nor the relevance of KAT-2 in the mouse brain has yet been clarified. Using acute mouse brain slice preparations, we investigated the basal and L-kynurenine (L-KYN) induced KYNA production and distribution between the extracellular and intracellular compartments. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183051
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http://dx.doi.org/10.1016/j.brainresbull.2018.12.014DOI Listing
March 2019
6 Reads

A splice site mutation causing exon 6 skipping in SLC20A2 gene in a primary familial brain calcification family.

Brain Res Bull 2019 Jan 8. Epub 2019 Jan 8.

Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, Hunan, PR China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410008, Hunan, PR China. Electronic address:

Background: Primary familial brain calcification (PFBC) is a rare degenerative disease characterized by symmetrical bilateral calcinosis in the basal ganglia and other brain regions. It has an autosomal dominant inheritance pattern in most cases and exhibits genetic heterogeneity. Previous studies reported that SLC20A2, PDGFRB, PDGFB, XPR1 and MYORG are associated with PFBC, with SLC20A2 the main culprit. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183054
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.006DOI Listing
January 2019
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RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3ß and JNK signaling pathways in dopaminergic neuron-like cells.

Brain Res Bull 2019 Mar 8;146:228-236. Epub 2019 Jan 8.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica & Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China. Electronic address:

Deletions or some mutations in the gene encoding the multifunctional protein, DJ-1, have been considered to be linked with autosomal recessive early onset Parkinson's disease (PD). Current emerging evidence suggests that DJ-1 is involved in the protection against oxidative stress-induced mitochondrial damage. However, the exact molecular mechanisms underlying this are not completely clear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183038
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.007DOI Listing
March 2019
6 Reads
2.718 Impact Factor

Recent therapeutic strategies targeting beta amyloid and tauopathies in Alzheimer's disease.

Brain Res Bull 2019 Mar 8;146:171-184. Epub 2019 Jan 8.

Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra, 400056, India. Electronic address:

Alzheimer's disease (AD) has been a global concern for years due to its severe implications that affects the quality of life of the patients. The available line of therapy for treating Alzheimer's includes acetylcholinesterase inhibitors, NMDA(N-methyl-D-aspartate) antagonists and their combination which gives only symptomatic relief rather than treating the root cause of AD. Senile plaques and neurofibrillary tangles are the characteristic features underlying Alzheimer's pathology. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.004DOI Listing
March 2019
17 Reads

The antinociceptive effect of anterior pretectal nucleus stimulation is mediated by distinct neurotransmitter mechanisms in descending pain pathways.

Brain Res Bull 2019 Mar 8;146:164-170. Epub 2019 Jan 8.

Universidade de São Paulo, Departamento de Farmacologia, Ribeirão Preto, SP, Brazil; Universidade de São Paulo, Departamento de Psicologia, Ribeirão Preto, SP, Brazil.

Electrical stimulation of the anterior pretectal nucleus (APtN) activates two descending pain inhibitory pathways. One of these pathways relays in the ipsilateral lateral paragigantocellular nucleus (LPGi), whereas the other pathway relays in the contralateral pedunculopontine tegmental nucleus (PPTg). Antinociceptive effect of APtN stimulation has been seen in various pain models in the rodents. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.003DOI Listing
March 2019
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Endoplasmic reticulum stress induced autophagy in 6-OHDA-induced Parkinsonian rats.

Brain Res Bull 2019 Mar 6;146:224-227. Epub 2019 Jan 6.

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Both endoplasmic reticulum (ER) stress and autophagy involve in the pathological process of Parkinson's disease (PD). But the relationship between them is not clear in PD. A 6-OHDA-induced parkinsonian rat is recognized as a standard model for many years, and it can be used in experimental study. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.01.001DOI Listing
March 2019
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Extracellular cardiolipin regulates select immune functions of microglia and microglia-like cells.

Brain Res Bull 2019 Mar 6;146:153-163. Epub 2019 Jan 6.

Department of Biology, University of British Columbia Okanagan Campus, Kelowna, British Columbia, V1V 1V7, Canada. Electronic address:

Cardiolipin is a mitochondrial membrane phospholipid with several well-defined metabolic roles. Cardiolipin can be released extracellularly by damaged cells and has been shown to affect peripheral immune functions. We hypothesized that extracellular cardiolipin can also regulate functions of microglia, the resident immune cells of the central nervous system (CNS). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183068
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http://dx.doi.org/10.1016/j.brainresbull.2019.01.002DOI Listing
March 2019
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Behavioral screening tools for identifying autism in macaques: existing and promising tests.

Brain Res Bull 2019 Mar 31;146:87-93. Epub 2018 Dec 31.

Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, 650223, China. Electronic address:

Autism is a behaviorally defined neurodevelopmental disease characterized by social communication and social interaction deficits, as well as repetitive behaviors and restricted interests. Although the causes of autism are extremely complex, involving genes, environments and gene-environment interactions, genetic mutations are the important risk factors. For this reason, preclinical research is now shifting into focusing on generating transgenic and knockout models, especially using macaques, which are the closest relatives to humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183081
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http://dx.doi.org/10.1016/j.brainresbull.2018.12.018DOI Listing
March 2019
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Natural health products, dietary minerals and over-the-counter medications as add-on therapies to antidepressants in the treatment of major depressive disorder: a review.

Brain Res Bull 2019 Mar 30;146:51-78. Epub 2018 Dec 30.

Department of Psychiatry and Psychotherapy, Semmelweis University, Faculty of Medicine, Budapest, Hungary; Nyiro Gyula National Institute of Psychiatry and Addictions, Budapest, Hungary.

Given the moderate efficacy of the currently available antidepressants (ADs) in the treatment of major depressive disorder (MDD), the identification of agents that are both able to enhance the effectiveness of ADs and have a good safety profile is a reasonable task for current psychopharmacology. In addition to the well-known drugs (second-generation antipsychotics, levothyroxine, dopaminergic agents, etc.) for augmentation, investigations suggest that several nutraceuticals and over-the-counter (OTC) drugs may be effective and safe as adjunct therapeutic agents to conventional ADs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183056
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http://dx.doi.org/10.1016/j.brainresbull.2018.12.015DOI Listing
March 2019
5 Reads

The antinociceptive effects and molecular mechanisms of ghrelin(1-7)-NH at the supraspinal level in acute pain in mice.

Brain Res Bull 2019 Mar 29;146:112-123. Epub 2018 Dec 29.

Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, 330006, China. Electronic address:

Ghrelin(1-7)-NH is the active N-terminal hepta-peptide of ghrelin as an agonist at the ghrelin receptor GHS-R1α. The biological functions of ghrelin(1-7)-NH have not been well investigated. Therefore in this study, we were interested in exploring the effects and molecular mechanisms of ghrelin(1-7)-NH in pain modulation at the supraspinal level using the tail withdrawal test in mice. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.016DOI Listing
March 2019
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Natural compounds acting at P2 receptors alleviate peripheral neuropathy.

Brain Res Bull 2018 Dec 29. Epub 2018 Dec 29.

Neuropharmacological Labratory of Physiology Department, Medical School of Nanchang University, Nanchang, Jiangxi, 330006, Peoples Republic of China; Jiangxi Provincial Key Laboratory of autonomic nervous function and disease, Nanchang, Jiangxi, 330006, People's Republic of China. Electronic address:

Neuropathic pain is generally resistant to currently available treatments, and it is often a consequence of nerve injury due to surgery, diabetes or infection. Myocardial ischemic nociceptive signaling increases the sympathoexcitatory reflex to aggravate myocardial injury. Elucidation of the pathogenetic factors might provide a target for optimal treatment. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.017DOI Listing
December 2018
2 Reads

Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice.

Brain Res Bull 2019 Mar 28;146:79-86. Epub 2018 Dec 28.

Center of Neuroscience Research, Institute of Medical and Health Science of HeBMU, Hebei Medical University, Shijiazhuang, 050017, China; Department of Biochemistry and molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China; Hebei Key Laboratory of Forensic Medicine, Hebei Medicinal University, 050017, China; Collaborative Innovation Center of Forensic Medical Molecular Identification, Hebei Medicinal University, 050017, China. Electronic address:

Depression is the root of various diseases. It is one of the most debilitating conditions globally. Antidepressant drugs are usually the first-line of depression treatment. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.005DOI Listing
March 2019
6 Reads
2.718 Impact Factor

Purinergic receptors in neurogenic processes.

Brain Res Bull 2018 Dec 26. Epub 2018 Dec 26.

Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900, Av. Prof. Lineu Prestes, 748, São Paulo, SP, Brazil. Electronic address:

Neurogenesis is a process of generating functional neurons, which occurs during embryonic and adult stages in mammals. While neurogenesis during development phase is characterized by intensive proliferation activity in all regions of the brain to form the architecture and neural function of the nervous system, adult neurogenesis occurs with less intensity in two brain regions and is involved in the maintenance of neurogenic niches, local repair, memory and cognitive functions in the hippocampus. Taking such differences into account, the understanding of molecular mechanisms involved in cell differentiation in developmental stages and maintenance of the nervous system is an important research target. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2018.12.013DOI Listing
December 2018
1 Read