75,013 results match your criteria Brain Research[Journal]


Inhibitory Control of Emotional Interference in Children with Learning Disorders: Evidence from Event-related Potentials and Event-related Spectral Perturbation Analysis.

Brain Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Health Promotion, Education, and Behavior, University of South Carolina, United States.

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http://dx.doi.org/10.1016/j.brainres.2019.04.016DOI Listing

Subtle differences in synaptic transmission in medial nucleus of trapezoid body neurons between wild-type and Fmr1 knockout mice.

Authors:
Yong Lu

Brain Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Anatomy and Neurobiology, College of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA. Electronic address:

In animal models for fragile X syndrome where the gene for fragile X mental retardation protein is knocked out (Fmr1 KO), neurotransmission in multiple brain regions shifts excitation/inhibition balance, resulting in hyperexcitability in neural circuits. Here, using whole-cell recordings from brainstem slices, we investigated synaptic transmission at the medial nucleus of trapezoid body (MNTB, a critical nucleus in the brainstem sound localization circuit), in Fmr1 KO and wild-type (WT) mice 2-3 weeks of age in both sexes. Surprisingly, neither synaptic excitation nor inhibition in KO neurons was significantly changed. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.006DOI Listing

The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Brain Health Institute, Rutgers University, Piscataway, NJ, USA.

There is considerable clinical interest in the neuropeptide orexin/hypocretin for its ability to regulate motivation and reward as well as arousal and wakefulness. For instance, antagonists for the orexin-1 receptor (OxR1) are thought to hold great promise for treating drug addiction and disorders associated with overeating, as these compounds repeatedly have been found to suppress seeking of various drugs of abuse as well as highly palatable foods in preclinical models. Given the hypothesized role of OxR1 signaling in cue-driven motivation, an outstanding question is whether pharmacologically blocking this receptor affects cognitive functioning. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.017DOI Listing

Motor cortex metabolite alterations in Amyotrophic Lateral Sclerosis assessed in vivo using edited and non-edited magnetic resonance spectroscopy.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Biomedical MRI unit/ MoSAIC, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium. Electronic address:

Previous MRI and proton spectroscopy (H-MRS) studies have revealed impaired neuronal integrity and altered neurometabolite concentrations in the motor cortex of patients with amyotrophic lateral sclerosis (ALS). Here, we aim to use MRI with conventional and novel MRS sequences to further investigate neurometabolic changes in the motor cortex of ALS patients and their relation to clinical parameters. We utilized the novel HERMES (Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy) MRS sequence to simultaneously quantify the inhibitory neurotransmitter GABA and antioxidant glutathione in ALS patients (n=7) and healthy controls (n=7). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.018DOI Listing

Morin post-treatment confers neuroprotection in a novel rat model of mild repetitive traumatic brain injury by targeting dementia markers, APOE, autophagy and Wnt/β-catenin signaling pathway.

Brain Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Pharmacology & Toxicology, Cairo University, Cairo, Egypt. Electronic address:

Exposure to repetitive brain trauma has gained attention for its similarity to sport-related trauma. The traumatic brain injury (TBI) is strongly associated with neurodegenerative pathology that affects cognition, memory and behavior. The current study developed a novel mild repetitive traumatic brain injury (mRTBI) model to highlight some of the possible molecular pathological mechanisms compared to those of single trauma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193018
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http://dx.doi.org/10.1016/j.brainres.2019.04.003DOI Listing
April 2019
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Untangling Narcolepsy and Diabetes: Pathomechanisms with Eyes on Therapeutic Options.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Student's Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran; NeuroImaging Network (NIN), Universal Scientific Education and Research Network (USERN), Tehran, Iran. Electronic address:

Narcolepsy (NA) is a primary sleep disorder characterized by loss of hypocretinergic/orexinergic neurons. NA is associated with an increased risk for metabolic disorders such as diabetes mellitus (DM). Proposed mechanisms for this association are alterations in food intake, disruption of energy balance, glucose tolerance, and insulin sensitivity, as well as inflammation and genetic factors. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.013DOI Listing

Cell based therapy reduces secondary damage and increases extent of microglial activation following cortical injury.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy & Neurobiology, 72 E. Concord Street, L-1004, Boston University School of Medicine, Boston, MA 02118 USA; Department of Neurology, 72 E. Concord Street, C3, Boston University School of Medicine, Boston, MA 02118 USA.

Cortical injury elicits long-term cytotoxic and cytoprotective mechanisms within the brain and the balance of these pathways can determine the functional outcome for the individual. Cytotoxicity is exacerbated by production of reactive oxygen species, accumulation of iron, and peroxidation of cell membranes and myelin. There are currently no neurorestorative treatments to aid in balancing the cytotoxic and cytoprotective mechanisms following cortical injury. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.015DOI Listing

Impaired dynamic cerebral autoregulation in patients with cerebral amyloid angiopathy.

Brain Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Neuroradiology, University Medical Center Freiburg, Germany.

Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 age-matched controls were examined with transcranial Doppler. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193020
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http://dx.doi.org/10.1016/j.brainres.2019.04.014DOI Listing
April 2019
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Changes to Gamma-Aminobutyric Acid Levels during Short-Term Epileptiform Activity in a Kainic Acid-Induced Rat Model of Status Epilepticus: A Chemical Exchange Saturation Transfer Imaging Study.

Brain Res 2019 Apr 13. Epub 2019 Apr 13.

MR Core Laboratory, Asan Medical Center, Asan Institute for Life Sciences, Seoul, Republic of Korea; Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: To evaluate temporal changes in gamma-aminobutyric acid (GABA) signals in the hippocampus during epileptiform activity induced by kainic acid (KA) in a rat model of status epilepticus using chemical exchange saturation transfer (CEST) imaging technique.

Methods: CEST imaging and H magnetic resonance spectroscopy (H MRS) were applied to a systemic KA-induced rat model to compare GABA signals. All data acquisition and analytical procedures were performed at three different time points (before KA injection, and 1 and 3 hours after injection). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.010DOI Listing

Maternal consumption of piceatannol: a nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates.

Brain Res 2019 Apr 13. Epub 2019 Apr 13.

CRMSB, UMR 5536, CNRS/University of Bordeaux, 146 Rue Léo Saignat, 33076 Bordeaux Cedex, France. Electronic address:

Hypoxia-ischemia (HI) remains a major cause of perinatal mortality and chronic disability in newborns worldwide (1-6 for 1,000 births) with a high risk of future motor, behavioral and neurological deficits. Keeping newborns under moderate hypothermia is the unique therapeutic approach but is not sufficiently successful as nearly 50% of infants do not respond to it. In a 7-day post-natal rat model of HI, we used pregnant and breastfeeding female nutritional supplementation with piceatannol (PIC), a polyphenol naturally found in berries, grapes and passion fruit, as a neuroprotective strategy. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.012DOI Listing
April 2019
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The influence of task complexity and information value on feedback processing in younger and older adults: no evidence for a positivity bias during feedback-induced learning in older adults.

Brain Res 2019 Apr 13. Epub 2019 Apr 13.

Department of Psychology, Saarland University, Saarbrücken, Germany. Electronic address:

Humans flexibly adapt their behavior using feedback from their environment. This ability is impaired in old age, but recent research suggests this mainly concerns processing of negative feedback and that positive feedback might be spared. The aim of this study was to test this idea of an age-related positivity bias against the possibility of a strategic focus on relevant feedback due to limited processing resources in old age. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.011DOI Listing

Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

School of Life Sciences, Guangzhou University, Guangzhou, 510006, China. Electronic address:

Citalopram (CTM), a selective serotonin reuptake inhibitor (SSRI), has been widely used to treat panic disorders, such as depression which is one of the most disabling, yet common, psychiatric disorders. Although prenatal antidepressant exposure has a major impact on the neurobehavioral development of the offspring, such as anxiety, depression- and autism-like behaviors, the brain alterations of SSRI influence remained largely unknown. We show here, using electrophysiological recordings, that CTM exposure during the last 7 d of gestation can alter theta- and gamma-band oscillation and synchronization in the corticostriatal loop of 2-3 month-old mouse offspring. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.008DOI Listing
April 2019
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Exosome-shuttled miR-92b-3p from ischemic preconditioned astrocytes protects neurons against oxygen and glucose deprivation.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province, China.

Ischemic preconditioning (IPC) exerts protective effects against ischemic cerebral injury. In the present study, an in vitro model of cerebral ischemia (oxygen and glucose deprivation, OGD) was established to investigate the neuroprotective mechanism of IPC. We found that conditioned medium (C. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.009DOI Listing

Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurology, The first affiliated hospital, China Medical University, Shenyang, Liaoning, PR China.

Remyelination has been widely noticed as an important repair mechanism triggered after a stroke-induced white matter injury, but it often fails due to the lack of recruitment of the oligodendrocyte progenitor cells (OPCs) to the demyelinated area and the inadequate differentiation of OPCs. Racemic dl-3-n-butylphthalide (dl-NBP) has been reported to improve the functional recovery in animal models of vascular dementia, Alzheimer's disease (AD) and ischemic stroke. Dl-NBP (70 mg/kg) by oral gavage for two weeks from day 7 after a stroke was administered in the study, the treatment promoted differentiation and maturation of OPCs in perilesional white matter and enhanced the length of crossing corticospinal tract (CST) fibers into the denervated hemispheres. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.017DOI Listing
April 2019
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High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

Mini-invasive Neurosurgery and Translational Medical Center, Xi'an Central Hospital, Xi'an Jiaotong University, West 5(th) Road, Xincheng District, Xi'an, 710003, PR China. Electronic address:

It has been generally accepted that inflammatory responses induced by status epilepticus (SE) in the brain are associated with microglial activation. One important regulator of microglial activation is high mobility group box-1 (HMGB1) protein. HMGB1 exerts its influence on microglia via various pathways including Toll-like receptor (TLR) subtypes 2 and 4. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193020
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http://dx.doi.org/10.1016/j.brainres.2019.04.007DOI Listing
April 2019
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2.843 Impact Factor

Sex differences in insular functional connectivity in response to noxious visceral stimulation in rats.

Brain Res 2019 Apr 8. Epub 2019 Apr 8.

Department of Psychiatry & Behavioral Sciences, University of Southern California, Los Angeles, CA 90089, USA; Departments of Neurology, Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.

Insular cortex (INS) plays a critical role in pain processing and shows sex differences in functional activation during noxious visceral stimulation. Less is known regarding functional interactions within the INS and between this structure and other parts of the brain. Cerebral blood flow mapping was performed using [C]-iodoantipyrine perfusion autoradiography in male and female rats during colorectal distension (CRD) or no distension (controls). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.005DOI Listing

Preface.

Prog Brain Res 2019 ;245:xiii-xvi

Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1016/S0079-6123(19)30076-7DOI Listing
January 2019

Nanowired delivery of DL-3-n-butylphthalide induces superior neuroprotection in concussive head injury.

Prog Brain Res 2019 2;245:89-118. Epub 2019 Apr 2.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Concussive head injury (CHI) is quite prevalent in military personnel leading to lifetime disability in more than 85% of cases. Other reasons of CHI include motor vehicle accident, fall or blunt trauma under various conditions. In United States of America (USA) alone more than 150k cases of head injury are added every year for which no suitable therapeutic strategies are still available. Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.008DOI Listing

Nanomedicine in Alzheimer's disease: Amyloid beta targeting strategy.

Prog Brain Res 2019 2;245:57-88. Epub 2019 Apr 2.

Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy. Electronic address:

The treatment of Alzheimer's disease (AD) is up to today one of the most unsuccessful examples of biomedical science. Despite the high number of literature evidences detailing the multifactorial and complex etiopathology of AD, no cure is yet present on the market and the available treatments are only symptomatic. The reasons could be ascribed on two main factors: (i) lack of ability of the majority of drugs to cross the blood-brain barrier (BBB), thus excluding the brain for any successful therapy; (ii) lack of selectivity and specificity of drugs, decreasing the efficacy of even potent anti-AD drugs. Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.001DOI Listing
April 2019
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Nanoparticles and neurotoxicity: Dual response of glutamatergic receptors.

Prog Brain Res 2019 2;245:281-303. Epub 2019 Apr 2.

Department of General Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey.

Although the use of nanoparticles for neuro-diagnostic and neurotherapeutic purposes provides superior benefits than the conventional approaches, it may be potentially toxic in central nervous system. In this respect, nanotechnological research focuses on nanoneurotoxicity-nanoneurosafety concepts. Despite these efforts, nanoparticles (NPs) may cause neurotoxicity, neuroinflammation, and neurodegeneration by penetrating the brain-olfactory route and blood-brain barrier (BBB). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00796123193003
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http://dx.doi.org/10.1016/bs.pbr.2019.03.005DOI Listing
April 2019
5 Reads

Nanodelivery of therapeutic agents in Parkinson's disease.

Prog Brain Res 2019 2;245:263-279. Epub 2019 Apr 2.

Neuropharmacology Group, University of the Basque Country (UPV-EHU), Leioa, Spain.

Parkinson's disease (PD) as a motor disorder is pathologically featured by the loss of dopaminergic neurons of the substantia nigra compacta (SNc) and the consequent depletion of dopamine in the striatum. However, motor signs are detectable when the loss of dopaminergic striatal terminals exceeds to the dopaminergic neuronal degeneration in SN. Hence, recent evidences about the topological organization of the nigrostriatal system could provide novel insights about the progression of the neurodegenerative process as well as the correct application of the novel therapeutic strategies. Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.004DOI Listing
April 2019
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Tellurium epigenetic transgenerational effects on behavioral expression of coping behavior in rats.

Prog Brain Res 2019 2;245:247-261. Epub 2019 Apr 2.

Laboratorio de Neuropsicofarmacología Experimental, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina. Electronic address:

An increasing interest has been developed in the past 15 years in the relationship between trace elements and cell functioning. In the present work the possibility of transgenerational effects of Te was investigated in rats. F generation exposed to KTeO (1. Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.003DOI Listing

Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease.

Prog Brain Res 2019 2;245:201-246. Epub 2019 Apr 2.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Parkinson's disease (PD) is affecting >10 million people worldwide for which no suitable cure has been developed so far. Roughly, about two people per thousand populations are affected with PD like symptoms especially over the age of 50. About 1% of the populations above 60 years suffer from PD-like disease. Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.014DOI Listing
April 2019
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Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease.

Prog Brain Res 2019 2;245:145-200. Epub 2019 Apr 2.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden.

Alzheimer's disease (AD) is estimated to be afflicting over 55 millions of individual worldwide in 2018-19 for which no suitable clinical therapeutic measures have been developed so far. Thus, there is an urgent need to explore novel therapeutic strategies using nanodelivery of drugs and agents either alone or in combination for superior neuroprotection in AD and enhanced quality of life of the affected individuals. There are reports that AD is often associated with diminished neurotrophic factors and neprilysin together with enhancement of phosphorylated Tau (p-Tau) within the brain and in the cerebrospinal fluid (CSF). Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.009DOI Listing
April 2019
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Oligodendrocyte precursor cells as a therapeutic target for demyelinating diseases.

Authors:
Stephen D Skaper

Prog Brain Res 2019 2;245:119-144. Epub 2019 Apr 2.

Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy. Electronic address:

The mechanisms regulating differentiation of multipotent oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes (OLs) are critical to our understanding of myelination and remyelination. Following acute demyelination in the central nervous system, adult OPCs migrate to the injury site, differentiate into OLs and generate new myelin sheaths. A common feature of regenerative processes is the fact that remyelination efficiency declines with aging and, accounts for the observation that chronic demyelinating diseases like multiple sclerosis (MS) are characterized by an ineffective remyelination. Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.013DOI Listing
April 2019
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Sleep deprivation exacerbates concussive head injury induced brain pathology: Neuroprotective effects of nanowired delivery of cerebrolysin with α-melanocyte-stimulating hormone.

Prog Brain Res 2019 2;245:1-55. Epub 2019 Apr 2.

International Experimental Central Nervous System Injury & Repair (IECNSIR), Department of Surgical Sciences, Anesthesiology & Intensive Care Medicine, Uppsala University Hospital, Uppsala University, Uppsala, Sweden. Electronic address:

Sleep deprivation (SD) is very common in military personnel resulting in mental anomalies and interfering with decision-making capabilities. Moreover during combat operation, these sleep-deprived soldiers often receive blunt head trauma casing concussive head injury (CHI). Recent observations clearly suggest that SD alone induces brain pathology and additional CHI further exacerbates brain damage. Read More

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http://dx.doi.org/10.1016/bs.pbr.2019.03.002DOI Listing

Electrophysiological changes in auditory evoked potentials in rats with salicylate-induced tinnitus.

Brain Res 2019 Apr 5. Epub 2019 Apr 5.

Graduate School of Biotechnology, Kyung Hee University, Republic of Korea; Department of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Global Campus, Gyeonggi, Republic of Korea. Electronic address:

Early-response Auditory Evoked Potentials (AEPs) in humans are significantly altered in tinnitus. These changes are closely related to that seen in animals, leading to new approaches to study tinnitus based on objective parameters. The purpose of this study was to characterize the AEPs in animals with tinnitus, by assessing early to late latency responses. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.004DOI Listing

Lithium counteracts depressive behavior and augments the treatment effect of selective serotonin reuptake inhibitor in treatment-resistant depressed rats.

Brain Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1, Shikata-cho, Kita-ku, Okayama-shi, Okayama 700-8558, Japan.

Wistar Kyoto (WKY) rats are a useful animal model of treatment-resistant depression. Lithium is effective for treating recurrent mood disorders or treatment-resistant depression, and lithium augmentation treatment is also useful for treatment-resistant depression. However, the treatment effect of lithium on the depressive behavior of WKY rats remains poorly understood, and whether lithium augments the treatment effect of antidepressants in WKY rats is also unknown. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.001DOI Listing
April 2019
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Melatonin Pretreatment Attenuates Acute Methamphetamine-induced Aggression in Male ICR Mice.

Brain Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Epidemiology & Health Statistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, 13 Hangkong Road, Wuhan 430030, China. Electronic address:

Aggression is one of the symptoms of methamphetamine (MA) use and withdrawal, which can exacerbate MA addiction and relapse. Many studies have demonstrated that poor sleep is significantly associated with aggression. Melatonin has been indicated to be effective in treating sleep disorders induced by MA, and it can also protect neuronal cells against MA-induced neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.04.002DOI Listing
April 2019
2 Reads

HCN channel antagonist ZD7288 ameliorates neuropathic pain and associated depression.

Brain Res 2019 Mar 30. Epub 2019 Mar 30.

Beijing Institute of Pharmacology and Toxicology, 27 Tai-Ping St, Beijing 100850, China. Electronic address:

Chronic neuropathic pain has demonstrated that coexisting psychiatric disorders are associated with disability and poorer treatment outcomes. Hyperpolarization-activated cyclic nucleotide-gated (HCN, Ih) channels play a major role in pain via hyperexcitability and facilitation of ectopic firing in neurons. Neuronal hyperexcitability contributes to pain maintenance and anxiety/depression. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.036DOI Listing
March 2019
1 Read
2.843 Impact Factor

GOLM1 silencing inhibits the proliferation and motility of human glioblastoma cells via the Wnt/β-catenin signaling pathway.

Brain Res 2019 Mar 29. Epub 2019 Mar 29.

Department of Neurosurgery, Renmin Hospital of Wuhan University, Hubei 430060, China; Brain Tumor Clinical Center of Wuhan, Hubei 430060, China. Electronic address:

Golgi membrane protein 1 (GOLM1) is a type II transmembrane protein located in the cis- and medial-Golgi. Due to its function as an oncogene and proprotein convertase (PC) consensus site, GOLM1 will play a vital role in gene-targeted therapies and serve as a candidate tumor biomarker. However, few studies have explored its correlation with glioblastoma (GBM) progression. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.035DOI Listing
March 2019
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Environmental enrichment as an experience-dependent modulator of social plasticity and cognition.

Brain Res 2019 Mar 28. Epub 2019 Mar 28.

Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, Victoria, Australia; Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Social plasticity is the ability to adaptively change the expression of social behaviour according to experience, allowing animals to optimize their social relationships in the context of previous experience and the complexities of social environments. Environmental enrichment (EE) mimics a stimulating lifestyle at the laboratory level and has demonstrated beneficial effects on various aspects of brain structure, function, behaviour and cognition. EE has also been shown to induce neuroprotection and functional compensation that is therapeutic in a range of different brain disorders. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.033DOI Listing
March 2019
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Intracerebroventricular injection of phoenixin alters feeding behavior and activates nesfatin-1 immunoreactive neurons in rats.

Brain Res 2019 Mar 28. Epub 2019 Mar 28.

Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charite - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany. Electronic address:

Phoenixin is a novel neuropeptide initially associated with reproductive functions, but subsequently also with feeding behavior. Nesfatin-1 is also involved in the regulation of food intake and has been shown to largely colocalize with phoenixin in the rat brain; however, a functional link is missing so far. The current study investigated whether phoenixin activates nesfatin-1 immunoreactive nuclei in the rat brain. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.034DOI Listing

Serotoninergic projection from dorsal raphe nucleus to insular cortex is involved in acute itch sensation processing in mice.

Brain Res 2019 Mar 27. Epub 2019 Mar 27.

Department of Human Anatomy, Histology and Embryology, Fujian Medical University, Fuzhou 350108, China; Department of Anatomy, Histology and Embryology & K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an 710032, China; Joint Laboratory of Neuroscience at Hainan Medical University and The Fourth Military Medical University, Hainan Medical University, Haikou 571199, China. Electronic address:

Previous studies have demonstrated that both dorsal raphe nucleus (DR) and insular cortex(IC) are critical for somatic sensory information transmission and regulation, especially for pain, and neurons in the DR send projection fibers to the IC. However, whether these ascending connections are involved in the processing of itch sensation remains unknown. In order to provide evidence for that, fluoro-gold (FG) retrograde tracing combined with immunofluorescent histochemical staining was performed for revealing the chemical nature of the projection neurons and the FOS expression induced by acute itch stimulation via intradermal histamine or chloroquine injection in the mouse. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.031DOI Listing
March 2019
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Longitudinal assessment of the neuroanatomical consequences of deep brain stimulation: Application of fornical DBS in an Alzheimer's mouse model.

Brain Res 2019 Mar 26. Epub 2019 Mar 26.

Cerebral Imaging Center, Douglas Mental Health University Institute, Montreal, Canada; Department of Psychiatry, McGill University, Montreal, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2019.03.030DOI Listing

Apelin-13 protects dopaminergic neurons in MPTP-induced Parkinson's disease model mice through inhibiting endoplasmic reticulum stress and promoting autophagy.

Brain Res 2019 Mar 23. Epub 2019 Mar 23.

Neurobiology Institute, Jining Medical University, 272067 Jining, China. Electronic address:

The dopaminergic neurodegeneration in the substantia nigrapars compacta (SNpc) and striatum of the midbrain is the important pathological feature of Parkinson's disease(PD). It has been shown that autophagy and endoplasmic reticulum stress (ERS) are involved in the occurrence and development of PD. The neuropeptide Apelin-13 is neuroprotective in the neurological diseases such as PD, Alzheimer's disease and cerebral ischemic stroke. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.027DOI Listing

The Effect of Cilostazol on Hippocampal Memory and Oxidative Stress Biomarkers in Rat Model of Diabetes Mellitus.

Brain Res 2019 Mar 23. Epub 2019 Mar 23.

Department of Clinical Pharmacy, College of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.

Diabetes is a global public health crisis worldwide, particularly in developing countries. Diabetes is characterized by a consistent elevation in blood glucose level which leads to several complications including cognitive impairment. Hippocampus, a brain structure responsible for memory, is vulnerable to damage caused by hyperglycemia-induced oxidative stress. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.025DOI Listing

Effects of methyl-beta-cyclodextrin on blood-brain barrier permeability in angiotensin II-induced hypertensive rats.

Brain Res 2019 Mar 23. Epub 2019 Mar 23.

Department of Physiology, Koç University School of Medicine, Istanbul, Turkey. Electronic address:

The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotensin (ANG) II-induced hypertensive rats. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.024DOI Listing

NMDA receptor modulation of the pedunculopontine tegmental nucleus underlies the motivational drive for feeding induced by midbrain dopaminergic neurons.

Brain Res 2019 Mar 23. Epub 2019 Mar 23.

Department of Animal and Human Physiology, University of Gdansk, 59 Wita Stwosza Str, 80-308 Gdansk, Poland.

The mesolimbic system, particularly the somatodendritic ventral tegmental area (VTA), is responsible for the positive reinforcing aspects of various homeostatic stimuli. In turn, the pedunculopontine tegmental nucleus (PPN) is anatomically and functionally connected with the VTA and substantia nigra (SN). In the present study, we investigated the role of glutamate receptors in the PPN in motivated behaviors by using a model of feeding induced by electrical stimulation of the VTA in male Wistar rats (n = 80). Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.028DOI Listing

Projections from lateral habenular to tail of ventral tegmental area contribute to inhibitory effect of stress on morphine-induced conditioned place preference.

Brain Res 2019 Mar 23. Epub 2019 Mar 23.

Department of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. Electronic address:

Physical stress is one of the most important factors affecting morphine-induced conditioned place preference (CPP). Convincing evidences demonstrate that physical stress can activate lateral habenular (LHb) neurons. However, the mechanism by which physical stress regulates morphine-induced CPP through LHb remains unclear. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.026DOI Listing
March 2019
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Antimycin A-induced mitochondrial dysfunction activates vagal sensory neurons via ROS-dependent activation of TRPA1 and ROS-independent activation of TRPV1.

Brain Res 2019 Mar 23. Epub 2019 Mar 23.

Department of Molecular Pharmacology & Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address:

Inflammation causes activation of nociceptive sensory nerves, resulting in debilitating sensations and reflexes. Inflammation also induces mitochondrial dysfunction through multiple mechanisms. Sensory nerve terminals are densely packed with mitochondria, suggesting that mitochondrial signaling may play a role in inflammation-induced nociception. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.029DOI Listing

Altered Functional Connectivity in Patients with Subcortical Ischemic Vascular Disease: A Resting-State fMRI Study.

Brain Res 2019 Mar 22. Epub 2019 Mar 22.

The Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Patients with subcortical ischemic vascular disease (SIVD) may hold a high risk of cognitive impairment (CI) by affecting the functional connectivity (FC) of resting-state networks (RSNs). Current studies have mainly focused on the patients with CI but have ignored the prodromal stage when people suffered subcortical vascular damage, but without CI. Independent component analysis (ICA) of rs-fMRI could detect altered FC in RSNs at the early stage of the disease. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.022DOI Listing

Functional parcellation of the hippocampus from resting-state dynamic functional connectivity.

Brain Res 2019 Mar 22. Epub 2019 Mar 22.

College of Artificial Intelligence, National University of Defense Technology, Changsha, Hunan 410073, China. Electronic address:

The hippocampus consists of functionally and structurally heterogeneous regions that are involved in multiple functions such as learning and memory. Previous studies on connectivity-based functional subdivisions of the hippocampus, however, overlooked the dynamic nature of resting-state functional connectivity (FC). In this study, we selected 50 subjects with the lowest head motion from the Human Connectome Project dataset and performed a two-stage spectral clustering technique to windowed FC correlations for identifying the potential covariant structures during the spontaneous fluctuation of hippocampal-cortical FC. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193016
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http://dx.doi.org/10.1016/j.brainres.2019.03.023DOI Listing
March 2019
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Differential expression of SV2A in hippocampal glutamatergic and GABAergic terminals during postnatal development.

Brain Res 2019 Mar 21. Epub 2019 Mar 21.

Department of Pharmacobiology, Centro de Investigación y Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico. Electronic address:

The function of synaptic vesicle protein 2A (SV2A) has not been clearly identified, although it has an essential role in normal neurotransmission. Changes in SV2A expression have been linked to several diseases that could implicate an imbalance between excitation and inhibition, such as epilepsy. Although it is known that SV2A expression is necessary for survival, SV2A expression and its relationship with γ-aminobutyric acid (GABA) and glutamate neurotransmitter systems along development has not been addressed. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.021DOI Listing

Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors.

Brain Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Pharmacology, Biological Science Sector, Federal University of Paraná, Curitiba, Paraná, Brazil; Institute of Neurosciences and Behavior (INeC) and Laboratory of Neuropsychopharmacology of Faculty of Philosophy, Sciences and Letters of University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results in painful conditions. Then, we aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as its involved mechanisms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193015
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http://dx.doi.org/10.1016/j.brainres.2019.03.014DOI Listing
March 2019
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Involvement of presynaptic TRPV1 channels in prostaglandin E-induced facilitation of spontaneous synaptic transmission in the rat spinal trigeminal subnucleus caudalis.

Brain Res 2019 Mar 18. Epub 2019 Mar 18.

Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan. Electronic address:

Prostaglandin E (PGE) synthesized in the central nervous system influences various physiological functions including nociception. Recently, we have demonstrated that PGE facilitates spontaneous synaptic transmission through presynaptic EP1 receptors in the spinal trigeminal subnucleus caudalis (Vc) neurons that receive nociceptive signals from the orofacial area. Increasing evidence suggests that the action of PGE is related to activation of transient receptor potential vanilloid 1 (TRPV1) channels. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.015DOI Listing

Activation of alpha7 acetylcholine receptors reduces neuropathic pain by decreasing dynorphin A release from microglia.

Brain Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Anesthesiology and Pediatric Clinical Pharmacology Laboratory, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Dynorphin A is increased in neuropathic pain models. Activation of α7 n acetylcholine receptor (nAchR) reduces inflammation and pain. Whether activation of α7 nAchR affects dynorphin A release is unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00068993193015
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http://dx.doi.org/10.1016/j.brainres.2019.03.016DOI Listing
March 2019
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Sericin alleviates restraint stress induced depressive- and anxiety-like behaviors via modulation of oxidative stress, neuroinflammation and apoptosis in the prefrontal cortex and hippocampus.

Brain Res 2019 Mar 18. Epub 2019 Mar 18.

Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

This study was aimed to examine the effects of sericin administration on restraint stress induced anxiety- and depressive-like behaviors, oxidative stress, inflammation and apoptosis in the prefrontal cortex (PFC) and hippocampus (HIP) of mice. Animals were subjected to chronic restraint stress (3 h/day for 21 days) to induce a depressive-like model. Sericin was administered at different doses (100, 150, and 200 mg/kg/day, gavage for 21 days) along with immobilization. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.020DOI Listing
March 2019
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The blockade of 5-HT receptors in the ventral tegmental area inhibited morphine/dextromethorphan-induced analgesia in pain rat models.

Brain Res 2019 Mar 18. Epub 2019 Mar 18.

Department of Animal Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran. Electronic address:

The aim of the present study was to determine the involvement of the VTA 5-HT receptors in analgesia induced by the co-administration of morphine and dextromethorphan (DM). Male Wistar rats were bilaterally cannulated in the VTA by the stereotaxic instrument. The tail-flick and formalin tests were performed to assess nociception in the acute and tonic pain conditions respectively. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.018DOI Listing

Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats.

Brain Res 2019 Mar 18. Epub 2019 Mar 18.

Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, 1-25-4 Digakunishi, Gifu 501-1196, Japan. Electronic address:

The mechanisms underlying central post-stroke pain are not well understood and there is no satisfactory treatment. Here, in a rat model of stroke, we measured nociceptive threshold using current stimulation of primary afferent neurons in both hind paws. Male Wistar rats underwent middle cerebral artery occlusion (MCAO) for 50 min. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.019DOI Listing
March 2019
3 Reads