75,670 results match your criteria Brain Research[Journal]


Synaptosome as a tool in Alzheimer's disease research.

Brain Res 2020 Jul 10:147009. Epub 2020 Jul 10.

Department of Anatomy, School of Biomedical Sciences, Brain Research New Zealand, University of Otago, Dunedin, New Zealand.

Synapse dysfunction is an integral feature of Alzheimer's disease (AD) pathophysiology. In fact, prodromal manifestation of structural and functional deficits in synapses much prior to appearance of overt pathological hallmarks of the disease indicates that AD might be considered as a degenerative disorder of the synapses. Several research instruments and techniques have allowed us to study synaptic function and plasticity and their alterations in pathological conditions, such as AD. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147009DOI Listing

Prolactin treatment reduces kainic acid-induced gliosis in the hippocampus of ovariectomized female rats.

Brain Res 2020 Jul 9:147014. Epub 2020 Jul 9.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México. Querétaro, Qro., 76230, México. Electronic address:

Neuroinflammation involves a set of responses occurring as a result of brain damage including astro- and microgliosis. In previous studies, we showed that treatment with prolactin (PRL) decreased neuronal loss induced by kainic acid (KA) in the hippocampus of female rats. This effect correlated with a decrease in astrogliosis. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147014DOI Listing

Neuroprotective effects of combination therapy of regional cold perfusion and hemoglobin-based oxygen carrier administration on rat transient cerebral ischemia.

Brain Res 2020 Jul 8:147012. Epub 2020 Jul 8.

Department of Neurosurgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

Regional cold perfusion and hemoglobin-based oxygen carrier administration both exert neuroprotective effects against cerebral ischemia reperfusion injury. We herein investigated whether the combination of these two therapies leads to stronger neuroprotective effects. Combination therapy was performed with the regional perfusion of cold HemoAct, a core-shell structured hemoglobin-albumin cluster, in a rat transient middle cerebral artery occlusion model. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147012DOI Listing

Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.

Brain Res 2020 Jul 8:147013. Epub 2020 Jul 8.

School of Natural Sciences and Health, Tallinn University, Narva Road 29, Astra Building, 10120 Tallinn, Estonia; Division of Neuropsychopharmacology, Department of Psychology, University of Tartu, Ravila 14A Chemicum, 50411 Tartu, Estonia. Electronic address:

Orexins/hypocretins maintain wakefulness, increase appetite and participate in the coordination of stress response. We have recently provided evidence on the role of orexins in aggression, showing the association of the HCRTR1 genotype (rs2271933 G>A; leading to amino acid substitution Ile408Val) with aggressiveness or breach of law in four independent cohorts. Aggressive behaviour can be reward driven and hence we have examined the association of HCRTR1 rs2271933 genotype with different aspects of reward sensitivity in the birth cohort representative Estonian Children Personality Behaviour and Health Study. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147013DOI Listing

Deep Brain Stimulation of the Infralimbic Cortex Attenuates Cocaine Priming-Induced Reinstatement of Drug Seeking.

Brain Res 2020 Jul 8:147011. Epub 2020 Jul 8.

Center for Neurobiology and Behavior, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

Deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of drug craving and addiction. To date, the nucleus accumbens has received the most attention as a potential target region for examining the impact of DBS on cocaine seeking in preclinical models. The present study investigated the effects of DBS in brain regions that send major glutamatergic projections to the nucleus accumbens including the basolateral amygdala (BLA) and ventral hippocampus (vHipp) as well as subregions of the medial prefrontal cortex (mPFC) including the anterior cingulate, infralimbic and prelimbic cortices. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147011DOI Listing

Curcumin-loaded nanoemulsion improves haemorrhagic stroke recovery in wistar rats.

Brain Res 2020 Jul 6:147007. Epub 2020 Jul 6.

Programa de Pós-graduação em Ciências Fisiológicas, Universidade Federal do Rio Grande (FURG), Rio Grande, RS, 96210-900, Brazil; Laboratório de Histologia, FURG, Rio Grande, RS, 96210-900, Brazil; Laboratório de Neurociências, Instituto de Ciências Biológicas, FURG, Rio Grande, RS, 96210-900, Brazil.

Cerebrovascular diseases are currently a major global health problem. Considering the limitations of current therapy, the search for new alternatives for the treatment of these diseases is necessary and, in this context, curcumin, a molecule that has neuroprotective properties already described in the literature. A limiting factor when considering therapies for the nervous tissue is the presence of the blood-brain barrier which stimulates the search for new drug delivery strategies. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147007DOI Listing

Cocaine added to heroin fails to affect heroin-induced brain hypoxia.

Brain Res 2020 Jul 6;1746:147008. Epub 2020 Jul 6.

Behavioral Neuroscience Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, DHHS, 251 Bayview Boulevard, Baltimore, MD 21224-6825, USA. Electronic address:

Heroin and cocaine are both highly addictive drugs that cause unique physiological and behavioral effects. These drugs are often co-administered and cocaine has been found in ~20% of cases of opioid overdose death. Respiratory depression followed by brain hypoxia is the most dangerous effect of high-dose opioids that could result in coma and even death. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147008DOI Listing

Cholecystokinin and bombesin activate neuronatin neurons in the nucleus of the solitary tract.

Brain Res 2020 Jul 3;1746:147006. Epub 2020 Jul 3.

Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Medical University in Berlin, Corporate Member of Freie Universität Berlin, Humboldt-University in Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Neuronatin (Nnat) is involved in the regulation of cellular molecular signaling and appears to be also linked to metabolic processes. The gastrointestinal peptides cholecystokinin (CCK) and bombesin (BN) have an effect on the short-term inhibition of food intake and induce neuronal activation in different brain nuclei, prominently in the nucleus of the solitary tract (NTS) involved in the modulation of food intake. The aim of the study was to examine if Nnat immunoreactivity is detectable in the NTS, and whether peripheral CCK-8S or BN cause c-Fos activation of Nnat neurons. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147006DOI Listing

Endothelial progenitor cell transplantation restores vascular injury in mice after whole-brain irradiation.

Brain Res 2020 Jul 2;1746:147005. Epub 2020 Jul 2.

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou 510080, China. Electronic address:

Vascular damage plays an important role in the pathogenesis of radiation-induced brain injury (RBI). Endothelial progenitor cells (EPCs) are responsible for maintaining and repairing endothelial function, and have become a promising method for the treatment of cerebrovascular diseases. However, whether EPC transplantation plays a protective role in RBI has not been fully elucidated. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147005DOI Listing

Alternating dual-task inference between visual words and faces.

Brain Res 2020 Jun 29;1746:147004. Epub 2020 Jun 29.

Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, Vancouver, Canada. Electronic address:

The many-to-many hypothesis proposes that face and visual word recognition share and even compete for high-level perceptual resources in both hemispheres. However, it is still not clear whether the processing performed by the two hemispheres on faces and visual words is equivalent or complementary. We performed an alternating dual-task experiment to determine if the processing of visual words and faces interfered with each other, and if such interference depended upon the stimulus attribute being processed. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147004DOI Listing

iTRAQ-based quantitative proteomic analysis of the therapeutic effects of 2% hydrogen gas inhalation on brain injury in septic mice.

Brain Res 2020 Jun 27;1746:147003. Epub 2020 Jun 27.

Department of Anesthesia, Tianjin Medical University General Hospital, Tianjin, China. Electronic address:

Sepsis encephalopathy (SAE) has a high incidence and mortality rate in patients with sepsis; however, there is currently no effective treatment. Our previous studies have reported that 2% hydrogen (H) gas inhalation had a protective effect on sepsis and SAE; however, the specific mechanism have not been fully elucidated. In the current study, male Institute of Cancer Research mice were either used to create the cecal ligation and puncture (CLP) model or for sham surgery, followed by 2% H gas inhalation for 60 min beginning at 1 and 6 h following sham or CLP surgeries. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147003DOI Listing

Effects of Toxoplasma gondii infection on the function and integrity of human cerebrovascular endothelial cells and the influence of Verapamil treatment in vitro.

Brain Res 2020 Jun 24:147002. Epub 2020 Jun 24.

Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire, LE12 5RD, UK. Electronic address:

Toxoplasma gondii can cause parasitic encephalitis, a life-threatening infection predominately occurs in immunocompromised individuals. T. gondii has the ability to invade the brain, but the mechanisms by which this parasite crosses the blood-brain-barrier (BBB) to cause brain damage remain incompletely understood. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147002DOI Listing

Comparison between midline and lateral fluid percussion injury in mice reveals prolonged but divergent cortical neuroinflammation.

Brain Res 2020 Jun 24;1746:146987. Epub 2020 Jun 24.

Department of Neuroscience, The Ohio State University, 333 W 10(th) Ave, Columbus, OH 43210, USA; Center for Brain and Spinal Cord Repair, The Ohio State University, 460 W 12(th) Ave, Columbus, OH 43210, USA; Institute for Behavioral Medicine Research, The Ohio State University, 460 Medical Center Dr, Columbus, OH 43210, USA. Electronic address:

Animal models are critical for determining the mechanisms mediating traumatic brain injury-induced (TBI) neuropathology. Fluid percussion injury (FPI) is a widely used model of brain injury typically applied either midline or parasagittally (lateral). Midline FPI induces a diffuse TBI, while lateral FPI induces both focal cortical injury (ipsilateral hemisphere) and diffuse injury (contralateral hemisphere). Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146987DOI Listing

Multiple doses of umbilical cord blood cells improve long-term brain injury in the neonatal rat.

Brain Res 2020 Jul 2;1746:147001. Epub 2020 Jul 2.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia. Electronic address:

Background: Hypoxic ischemic (HI) insults during pregnancy and birth can result in neurodevelopmental disorders, such as cerebral palsy. We have previously shown that a single dose of umbilical cord blood (UCB) cells is effective at reducing short-term neuroinflammation and improves short and long-term behavioural outcomes in rat pups. A single dose of UCB was not able to modulate long-term neuroinflammation or brain tissue loss. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147001DOI Listing

The contribution of stem cell factor and granulocyte colony-stimulating factor in reducing neurodegeneration and promoting neurostructure network reorganization after traumatic brain injury.

Brain Res 2020 Jun 21;1746:147000. Epub 2020 Jun 21.

Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. Electronic address:

Traumatic brain injury (TBI) is a major cause of death and disability in young adults worldwide. TBI-induced long-term cognitive deficits represent a growing clinical problem. Stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) are involved in neuroprotection and neuronal plasticity. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147000DOI Listing

A Src family kinase maintains latent sensitization in rats, a model of inflammatory and neuropathic pain.

Brain Res 2020 Jun 21;1746:146999. Epub 2020 Jun 21.

Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States; Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, United States. Electronic address:

Latent sensitization is a long-term model of chronic pain in which hyperalgesia is continuously suppressed by opioid receptors, as demonstrated by the induction of mechanical allodynia by opioid antagonists. Different intracellular signals may mediate the initiation, maintenance and expression of latent sensitization. Our criterion for the involvement of a signal in the maintenance of latent sensitization is that inhibitors should permanently eliminate the allodynia produced by an opioid antagonist. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146999DOI Listing

Neurophysiological markers of cognitive deficits and recovery in concussed adolescents.

Brain Res 2020 Jun 20;1746:146998. Epub 2020 Jun 20.

McMaster University - ARiEAL Research Centre, L.R. Wilson Hall, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4M2, Canada; McMaster University - Department of Linguistics and Languages, Canada; McMaster University - School of Biomedical Engineering, McMaster University, ETB-406, 1280 Main St., West, Hamilton, ON L8S 4K1, Canada; McMaster University - Department of Psychology, Neuroscience and Behaviour, Canada; MaRS Centre - Vector Institute, Canada. Electronic address:

Objective: The present study sought to determine: 1) whether concussed adolescents exhibited deficits in neurocognitive functioning as reflected by neurophysiological alterations; 2) if neurophysiological alterations could be linked to supplementary data such as the number of previous concussions and days since injury; and 3) if deficits in psychological health and behavioural tests increased during diagnosis duration.

Methods: Twenty-six concussed adolescents were compared to twenty-eight healthy controls with no prior concussions. Self-report inventories evaluated depressive and concussive symptomatology, while behavioral tests evaluated cognitive ability qualitatively. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146998DOI Listing

Subanesthetic ketamine exerts antidepressant-like effects in adult rats exposed to juvenile stress.

Brain Res 2020 Jun 13;1746:146980. Epub 2020 Jun 13.

Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, Sapporo 060-8638, Japan. Electronic address:

Juvenile stress, like that caused by childhood maltreatment, is a significant risk factor for psychiatric disorders such as depression later in life. Recently, the antidepressant effect of ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, has been widely investigated. However, little is known regarding its efficacy against depressive-like alterations caused by juvenile stress, which is clinically relevant in human depression. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146980DOI Listing

Dynamic changes of brain networks during feedback-related processing of reinforcement learning in schizophrenia.

Brain Res 2020 Jun 13;1746:146979. Epub 2020 Jun 13.

School of Medical Engineering, Xinxiang Medical University, Xinxiang 453003, PR China; Engineering Technology Research Center of Neurosense and Control of Xinxiang City, Xinxiang 453003, PR China; Xinxiang Key Laboratory of Biomedical Information Research, Henan Engineering Laboratory of Combinatorial Technique for Clinical and Biomedical Big Data, Xinxiang 453003, PR China. Electronic address:

Previous studies have reported that schizophrenia (SZ) patients showed selective reinforcement learning deficits and abnormal feedback-related event-related potential (ERP) components. However, how the brain networks and their topological properties evolve over time during transient feedback-related cognition processing in SZ patients has not been investigated so far. In this paper, using publicly available feedback-related ERP data which were recorded from SZ patients and healthy controls (HC) when they performed a reinforcement learning task, we carried out an event-related network analysis where topology of brain functional networks was characterized with some graph measures including clustering coefficient (C), global efficiency (E) and local efficiency (E) on a millisecond timescale. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146979DOI Listing

A proportionally suppressed and prolonged LPP acts as a neurophysiological correlate of face identity aftereffect.

Brain Res 2020 Jun 11;1746:146969. Epub 2020 Jun 11.

Faculty of Psychology, Southwest University, Chongqing 400715, China. Electronic address:

The recognition of facial identity is fundamentally important in daily life and social interactions. Here, we asked how the perception of facial identity is influenced by the set of preceding faces that observers are exposed to. We morphed the faces of Adam and Bob to generate a continuum of face images, and asked subjects to judge the identity of those face images to be Adam or Bob after they were exposed to a face image within the continuum. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146969DOI Listing

The ansa peduncularis in the human brain: A tractography and fiber dissection study.

Brain Res 2020 Jun 11;1746:146978. Epub 2020 Jun 11.

Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China. Electronic address:

Introduction: The ansa peduncularis is a composite of white matter fiber bundles closely packed together that sweeps around the cerebral peduncle. The exact components of the ansa peduncularis and their anatomical trajectories are still not established firmly in the literature.

Objective: The aim of this study was to examine the topographical anatomy of the ansa peduncularis and its subcomponents using the fiber dissection and tractography techniques. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146978DOI Listing

Locomotor mal-performance and gait adaptability deficits in sickle cell mice are associated with vascular and white matter abnormalities and oxidative stress in cerebellum.

Brain Res 2020 Jun 10;1746:146968. Epub 2020 Jun 10.

Department of Perioperative Medicine, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:

Patients with sickle cell disease (SCD) can develop strokes and as a result, present neurologic and neurocognitive deficits. However, recent studies show that even without detectable cerebral parenchymal abnormalities on imaging studies, SCD patients can have significant cognitive and motor dysfunction, which can present as early as during infancy. As the cerebellum plays a pivotal role in motor and non-motor functions including sensorimotor processing and learning, we examined cerebellar behavior in humanized SCD mice using the Erasmus ladder. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146968DOI Listing
June 2020
2.843 Impact Factor

Orexin cell transplant reduces behavioral arrest severity in narcoleptic mice.

Brain Res 2020 Oct 9;1745:146951. Epub 2020 Jun 9.

Departamento de Neuropatología Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, Coyoacán, Ciudad de México 04510, Mexico.

Narcolepsy is a sleep disorder that has been associated with the loss of orexinergic neurons from the lateral hypothalamic area. This loss leads to dysregulated sleep and cataplexy attacks. Therapeutic options are currently limited to symptom management with pharmacotherapy and nonpharmacological approaches. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146951DOI Listing
October 2020

L-lactate preconditioning promotes plasticity-related proteins expression and reduces neurological deficits by potentiating GPR81 signaling in rat traumatic brain injury model.

Brain Res 2020 Jun 9;1746:146945. Epub 2020 Jun 9.

Department of Anesthesiology, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China. Electronic address:

Currently, there is no efficacious pharmacological treatment for traumatic brain injury (TBI). Previous studies revealed that L-lactate preconditioning has shown rich neuroprotective effects against cerebral ischemia, and therefore has the potential to improve neurological outcomes after TBI. L-lactate played a neuroprotective role by activating GPR81 in diseases of the central nervous system (CNS) such as TBI and cerebral ischemia. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146945DOI Listing
June 2020
2.843 Impact Factor

Early but not late conformational changes of tau in association with ubiquitination of neurofibrillary pathology in Alzheimer's disease brains.

Brain Res 2020 Oct 8;1744:146953. Epub 2020 Jun 8.

Department of Cell Biology, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico. Electronic address:

In Alzheimer's disease, tau protein undergoes post-translational modifications including hyperphosphorylation and truncation, which promotes two major conformational changes associated with progressive N-terminal folding. Along with the development of the disease, tau ubiquitination was previously shown to emerge in the early and intermediate stages of the disease, which is closely associated with early tau truncation at aspartic acid 421, but not with a subsequently truncated tau molecule at glutamic acid 391. In the same group of cases, using multiple immunolabeling and confocal microscopy, a possible relationship between the ubiquitin-targeting of tau and the progression of conformational changes adopted by the N-terminus of this molecule was further studied. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146953DOI Listing
October 2020
2.843 Impact Factor

Prenatal exposure to lipopolysaccharide induces changes in the circadian clock in the SCN and AA-NAT activity in the pineal gland.

Brain Res 2020 Sep 8;1743:146952. Epub 2020 Jun 8.

Department of Physiology, Faculty of Science, Charles University in Prague, Czech Republic; National Institute of Mental Health, Klecany, Czech Republic. Electronic address:

The mammalian circadian pacemaker in the suprachiasmatic nucleus (SCN) regulates behavioral and physiological processes in a 24-h cycle. During its development, the SCN can be sensitive to external stimuli which may change the circadian phenotypes in adulthood. Here, we investigated the effects of prenatal exposure to endotoxin lipopolysaccharide (LPS) on the developing rhythms in expression of Per1, Per2, Nr1d1 and Rasd1 along the rostrocaudal axis of the SCN, and on the rhythm of the rate-limiting enzyme in melatonin synthesis, pineal alkylamine N-acetyltransferase (AA-NAT). Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146952DOI Listing
September 2020

Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats.

Brain Res 2020 Oct 8;1745:146948. Epub 2020 Jun 8.

Department of Pathology Chongqing Medical University, Yixueyuan Road 1, 400016 Chongqing, China. Electronic address:

Aims: The lack of effective treatments for ischemic stroke is concerning. Here, we aimed to examine the protective effects of sestrin2 in ischemic stroke and determine the mechanism by which sestrin2 attenuates cerebral injuries.

Main Methods: Ischemic stroke was induced in Sprague-Dawley rats using a photothrombotic ischemia (PTI) model. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146948DOI Listing
October 2020

CD44 expression in the cuprizone model.

Brain Res 2020 Oct 7;1745:146950. Epub 2020 Jun 7.

Department of Anatomy II, Ludwig-Maximilians-University of Munich, Pettenkoferstr. 11, 80336 Munich, Germany. Electronic address:

Numerous studies report that changes in extracellular matrix components and receptors, such as CD44, contribute to immune cell recruitment and thus lesion formation in multiple sclerosis (MS). In the present study, we used the cuprizone model to elucidate the expression pattern of CD44 in a toxin-induced MS model. Therefore, tissues of cuprizone-intoxicated mice were analyzed by real-time qRT-PCR and immunohistochemical staining against CD44. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146950DOI Listing
October 2020

MS275 reduces seizure-induced brain damage in developing rats by regulating p38 MAPK signaling pathways and epigenetic modification.

Brain Res 2020 Oct 6;1745:146932. Epub 2020 Jun 6.

Department of Pediatrics, The Second Hospital, University of South China, Hengyang, Hunan 421001, China.

Seizure is a common acute and severe disease in infants and children. Recurrent seizures or persistent seizures may cause irreversible brain damage. Mitogen activated protein kinase (MAPK) signaling pathway is associated with an inflammatory response, however it's involvement in the pathological process of seizures is not clear. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146932DOI Listing
October 2020

Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β.

Brain Res 2020 Oct 6;1745:146946. Epub 2020 Jun 6.

Department of Anesthesiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China. Electronic address:

Glutaredoxin 2 (GRX2) is an antioxidative protein that exerts a key role in various pathological processes. However, whether GRX2 participates in modulating the oxidative stress during cerebral ischemia/reperfusion, injury is undermined. This study aimed to determine the potential role of GRX2 in regulating oxidative stress in cultured neurons induced by oxygen-glucose deprivation/reoxygenation (OGD/R), a cellular model for study of cerebral ischemia/reperfusion injury in vitro. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146946DOI Listing
October 2020

LncRNA double homeobox A pseudogene 8 (DUXAP8) facilitates the progression of neuroblastoma and activates Wnt/β-catenin pathway via microRNA-29/nucleolar protein 4 like (NOL4L) axis.

Brain Res 2020 Jun 6;1746:146947. Epub 2020 Jun 6.

Second Department of Pediatrics, The First Affiliated Hospital of Jiamusi University In Jiamusi, Heilongjiang, China.

The potential mechanism of neuroblastoma (NB) progression remains elusive. We intended to uncover the role and network of long noncoding RNA (lncRNA) double homeobox A pseudogene 8 (DUXAP8) in NB. Quantitative real time polymerase chain reaction (qRT-PCR) was performed to detect the levels of DUXAP8, microRNA-29 (miR-29) and nucleolar protein 4 like (NOL4L). Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146947DOI Listing

Blockade of adenosine A1 receptor in nucleus tractus solitarius attenuates baroreflex sensitivity response to dexmedetomidine in rats.

Brain Res 2020 Sep 6;1743:146949. Epub 2020 Jun 6.

Department of Anesthesiology, Affiliated Hospital of Guizhou Medical University, Guiyang, China. Electronic address:

The α-adrenergic receptor (α-AR) agonist dexmedetomidine increases baroreflex sensitivity (BRS). In the current study, we examined the potential role of adenosine A1 receptor (A1R) within the nucleus tractus solitaries (NTS) in such a response. Briefly, adult male Sprague-Dawley rats were anesthetized and randomly received microinjection of selective A1R antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX; 0. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146949DOI Listing
September 2020

Neonatal handling increases neurogenesis, BDNF and GR in the hippocampus favoring memory acquisition in rats.

Brain Res 2020 Oct 4;1745:146921. Epub 2020 Jun 4.

Programa de Pós Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil; Programa de Pós Graduação em Farmacologia, UFSM, Santa Maria, RS, Brazil; Departamento de Fisiologia e Farmacologia, UFSM, Santa Maria, RS, Brazil. Electronic address:

Early life is a critical period for the development of the central nervous system (CNS) when the brain undergoes functional organization, neuronal proliferation and migration. This study aimed to evaluate influences and possible interactions of the neonatal handling (NH) on morphologic, biochemical and molecular markers in the hippocampus, as well as on Mu opioid receptors (MOR) immunoreactivity when adolescent rats were exposed to morphine. On postnatal day (PND) 1, male pups were assigned to two experimental groups: unhandled (UH) or neonatal handling (NH), whose procedure was applied from PND2 to PND9. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146921DOI Listing
October 2020

Impaired cerebral blood flow regulation in chronic traumatic brain injury.

Brain Res 2020 Sep 4;1743:146924. Epub 2020 Jun 4.

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX 75390, USA; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, 8200 Walnut Hill Ln, Dallas, TX 75231, USA.

Baroreflex sensitivity (BRS) and cerebral autoregulation (CA) play an important role in maintaining constant cerebral blood flow (CBF) during systemic changes in blood pressure (BP). Impaired BRS and CA have been reported in acute traumatic brain injury (TBI) which may also contribute to secondary injury and poorer recovery after acute TBI; however, their status during chronic stages remains elusive. Thus, the goal of this study is to determine whether cardiac BRS and dynamic CA (dCA) were impaired during the chronic stage in patients with single TBI and persistent neurological symptoms. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146924DOI Listing
September 2020

Pubertal stress decreases sexual motivation and supresses the relation between cerebral theta rhythms and testosterone levels in adult male rats.

Brain Res 2020 Oct 4;1745:146937. Epub 2020 Jun 4.

Psychology Department, Tromsø University, Tromsø, Norway.

This study evaluated the effect of stress during puberty on sexual motivation and the correlation between serum testosterone levels (T) and the absolute power of the theta electroencephalographic rhythms, recorded in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) of adult male rats. Thirty males of the stressed group (SG, housed 1 per cage from days 25-50) and 30 controls (CG, housed 5 per cage), were tested in copulatory interactions at 90 days of age. The above mentioned physiological parameters were obtained during the awake-quiet state in a sub-group without sexual motivation (WSM, n = 15, stimulated with a nonreceptive female) and a sub-group with sexual motivation (SM, n = 15, stimulated with a receptive-female). Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146937DOI Listing
October 2020

Antioxidant nanomedicine with cytoplasmic distribution in neuronal cells shows superior neurovascular protection properties.

Brain Res 2020 Sep 3;1743:146922. Epub 2020 Jun 3.

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, Japan; Department of Neurosurgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tennodai 1-1-1, Tsukuba, Ibaraki, Japan.

This study investigated whether nitroxide radical (4-amino-TEMPOL)-containing nanoparticles (RNPs; antioxidant nanomedicine) can prevent neurovascular unit impairment caused by reactive oxygen species (ROS) after cerebral ischemia-reperfusion. C57BL/6J mice underwent transient middle cerebral artery occlusion (tMCAO). The mice were randomly divided and administered intra-arterial RNPs injection (9 mg/kg, 7 μM/kg), edaravone (3 mg/kg, 17 μM/kg), or phosphate-buffered saline (control group). Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146922DOI Listing
September 2020

Autophagy associated with the efficacy of valproic acid in PTZ-induced epileptic rats.

Brain Res 2020 Oct 3;1745:146923. Epub 2020 Jun 3.

Department of Pharmacy, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai 201102, China. Electronic address:

Valproic acid (VPA) is a widely used antiepileptic drugs. Patients who are non-responsive to VPA often present to the clinic; however, the mechanism of resistance is unclear. In this study, we found that responder and non-responder pentylenetetrazole-induced chronic epileptic rats had no significant differences in VPA concentrations in their plasma and brain tissues. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146923DOI Listing
October 2020

Neuroprotective efficacy of luteolin on a 900-MHz electromagnetic field-induced cerebellar alteration in adult male rat.

Brain Res 2020 Oct 30;1744:146919. Epub 2020 May 30.

Department of Histology and Embryology, Faculty of Medicine, Okan University, Istanbul, Turkey.

The adverse health consequences of exposure to electromagnetic field emitted from cell phone has recently raised public concerns worldwide. Also, the Global System for Mobile Communications (GSM) standard that operates in 900 MHz frequency is the most popular. Therefore, we aimed to investigate the adverse effect of exposure to 900 MHz EMF (1 h/day) on the cerebella of 12-week-old rats. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146919DOI Listing
October 2020

Hippocampal coding of conspecific position.

Brain Res 2020 Oct 30;1745:146920. Epub 2020 May 30.

Department of Psychology, University of Otago, Dunedin 9016, New Zealand; Brain Health Research Centre, Division of Sciences, University of Otago, Dunedin 9016, New Zealand. Electronic address:

Many previous studies have shown that hippocampal place cells respond to the spatial position of the animal itself. Several recent studies have shown that place cells in an observer animal can also encode the location of a conspecific. The interpretation of these previous studies is, however, compromised by the fact that the observer animal was required to complete a movement that was either a duplication of the others trajectory, or a modification of it. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146920DOI Listing
October 2020

One physical exercise session promotes recognition learning in rats with cognitive deficits related to amyloid beta neurotoxicity.

Brain Res 2020 Oct 30;1744:146918. Epub 2020 May 30.

Physiology Research Group, Stress, Memory and Behavior Lab, Federal University of Pampa, Uruguaiana, RS, Brazil. Electronic address:

Alzheimer's disease is a progressive neurodegenerative pathological process that causes memory loss and cognitive impairment. One of the pathological characteristics of Alzheimer's disease is the amyloid-β protein aggregation on the brain. The regular practice of physical exercise is a consolidated strategy on the prevention of cognitive deficits; however, little is known about the effects of acute exercise on memory. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146918DOI Listing
October 2020

Restraint stress increases the expression of phoenixin immunoreactivity in rat brain nuclei.

Brain Res 2020 Sep 28;1743:146904. Epub 2020 May 28.

Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charite - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany; Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen, Germany. Electronic address:

Phoenixin is a recently discovered peptide, which has been associated with reproduction, anxiety and food intake. Based on a considerable co-localization it has been linked to nesfatin-1, with a possible antagonistic mode of action. Since nesfatin-1 is known to play a role in anxiety and the response to stress, this study aims to investigate the effects of a well-established psychological stress model, restraint stress, on phoenixin-expressing brain nuclei and phoenixin expression in rats. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146904DOI Listing
September 2020

Repeated psychosocial stress causes glutamic acid decarboxylase isoform-67, oxidative-Nox-2 changes and neuroinflammation in mice: Prevention by treatment with a neuroactive flavonoid, morin.

Brain Res 2020 Oct 28;1744:146917. Epub 2020 May 28.

Inflammatory and Immunopharmacology Unit, Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria.

Psychosocial stress and biological predispositions are linked to mood and personality disorders related to psychiatric behaviors. Targeting neuroinflammation and oxidative stress has been recognized as a potential strategy for the prevention of psychosocial stress-induced psychiatric disorders. Morin, a bioactive compound isolated from mulberry leaf has been shown to produce antiamnesic, antipsychotic and anti-inflammatory effects relative to ginseng, a well-known adaptogen. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146917DOI Listing
October 2020
2.843 Impact Factor

Repeated exposure of naïve and peripheral nerve-injured mice to a snake as an experimental model of post-traumatic stress disorder and its co-morbidity with neuropathic pain.

Brain Res 2020 10 28;1744:146907. Epub 2020 May 28.

Laboratory of Neuroanatomy and Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, 14049-900 São Paulo, Brazil; Ophidiarium LNN-FMRP-USP/INeC, Ribeirão Preto Medical School of the University of São Paulo, Av. Bandeirantes, 3900, Ribeirão Preto, 14049-900 São Paulo, Brazil; Behavioural Neurosciences Institute (INeC), Avenida do Café, 2450, Ribeirão Preto, 14050-220 São Paulo, Brazil; University of São Paulo Neurobiology of Emotions Research Centre (NAP-USP-NuPNE), Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, 14049-900 São Paulo, Brazil. Electronic address:

Confrontation of rodents by natural predators provides a number of advantages as a model for traumatic or stressful experience. Using this approach, one of the aims of this study was to investigate a model for the study of post-traumatic stress disorder (PTSD)-related behaviour in mice. Moreover, because PTSD can facilitate the establishment of chronic pain (CP), and in the same way, patients with CP have an increased tendency to develop PTSD when exposed to a traumatic event, our second aim was to analyse whether this comorbidity can be verified in the new paradigm. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146907DOI Listing
October 2020

Malnourishment during early lactation disrupts the ontogenetic distribution of the CART and α-MSH anorexigenic molecules in the arcuate/paraventricular pathway and lateral hypothalamus in male rats.

Brain Res 2020 Sep 27;1743:146906. Epub 2020 May 27.

Laboratório de Neurobiologia do Desenvolvimento, Departamento de Farmacologia e Psicobiologia, Instituto de Biologia Roberto Alcantara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

Developmental malnourishment impacts the energetic metabolism control throughout life. In rat offspring, a 0% protein diet during the first 10 days of lactation results in leptin resistance and in alterations in: feeding behavior, serum leptin and neuropeptide Y (NPY) levels in the hypothalamic arcuate nucleus (ARC)/paraventricular (PVN) pathway. Here, the distributions of alpha-melanocyte stimulating hormone (α-MSH) and cocaine and amphetamine regulated transcript (CART), anorexigenic molecules, were immunohistochemically assessed in the ARC, PVN and lateral hypothalamus (LH) nuclei. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146906DOI Listing
September 2020

The Vps52 subunit of the GARP and EARP complexes is a novel Arf6-interacting protein that negatively regulates neurite outgrowth of hippocampal neurons.

Brain Res 2020 Oct 28;1745:146905. Epub 2020 May 28.

Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan. Electronic address:

ADP ribosylation factor 6 (Arf6) is a small GTP-binding protein implicated in neuronal morphogenesis through endosomal trafficking and actin remodeling. In this study, we identified Vps52, a core subunit of the Golgi-associated retrograde protein (GARP) and endosome-associated recycling protein (EARP) complexes, as a novel Arf6-binding protein by yeast two-hybrid screening. Vps52 interacted specifically with GTP-bound Arf6 among the Arf family. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146905DOI Listing
October 2020

Beneficial effects of physical activity on depressive and OCD-like behaviors in the male offspring of morphine-abstinent rats.

Brain Res 2020 Oct 27;1744:146908. Epub 2020 May 27.

Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran. Electronic address:

The role of parental morphine exposure before gestation on mood disorder in the offspring was well described. Besides, physical activity can improve the symptoms of mood disorders. So, the current study aimed to investigate the role of physical activity on depressive and OCD-like behaviors induced by parental morphine exposure. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146908DOI Listing
October 2020

Evidence that the Kennedy and polyamine pathways are dysregulated in human brain in cases of dementia with Lewy bodies.

Brain Res 2020 Sep 22;1743:146897. Epub 2020 May 22.

Beaumont Research Institute, Royal Oak, MI 48073, USA; Oakland University-William Beaumont School of Medicine, Rochester, MI 48309, USA. Electronic address:

Disruptions of brain metabolism are considered integral to the pathogenesis of dementia, but thus far little is known of how dementia with Lewy bodies (DLB) impacts the brain metabolome. DLB is less well known than other neurodegenerative diseases such as Alzheimer's and Parkinson's disease which is perhaps why it is under-investigated. This exploratory study aimed to address current knowledge gaps in DLB research and search for potentially targetable biochemical pathways for therapeutics. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146897DOI Listing
September 2020

Epimedium flavonoids improve cognitive impairment and white matter lesions induced by chronic cerebral hypoperfusion through inhibiting the Lingo-1/Fyn/ROCK pathway and activating the BDNF/NRG1/PI3K pathway in rats.

Brain Res 2020 Sep 22;1743:146902. Epub 2020 May 22.

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Center for Clinical Medicine of Geriatric Diseases, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing Engineering Research Center for Nerve System Drugs, Beijing Institute for Brain Disorders, Beijing, China. Electronic address:

Chronic cerebral hypoperfusion is a common cause of cerebral small vascular disease (CSVD). White matter (WM) lesions are the typical pathological manifestation of CSVD and contribute to cognitive decline. Epimedium flavonoids (EF) are the main component in Epimedium brevicornu Maxim. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146902DOI Listing
September 2020

Effects of seawater immersion on open traumatic brain injury in rabbit model.

Brain Res 2020 Sep 20;1743:146903. Epub 2020 May 20.

Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Basic Medical Sciences, Key Laboratory of Environment and Genes Related to Diseases of Education Ministry of China, Xi an 710061, China. Electronic address:

We emulated instances of open traumatic brain injuries (TBI) in a maritime disaster. New Zealand rabbit animal models were used to evaluate the pathophysiological changes in open TBI with and without the influence of artificial seawater. New Zealand rabbits were randomly divided into 3 groups. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146903DOI Listing
September 2020

Visualization of cortical cerebral blood flow dynamics during craniotomy in acute subdural hematoma using laser speckle imaging in a rat model.

Brain Res 2020 Sep 20;1742:146901. Epub 2020 May 20.

Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, PR China; Department of Neurosurgery, 900th Hospital, Fuzhou, PR China. Electronic address:

Mass evacuation with decompressive craniotomy is considered a standard intervention for acute subdural hematoma (ASDH). However, hemispheric swelling complicates the intraoperative and postoperative management of ASDH patients, and previous studies have revealed that this approach can damage ischemic/reperfusion (I/R) injury. Few studies have focused on the cerebrovascular response following traumatic brain injury (TBI). Read More

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http://dx.doi.org/10.1016/j.brainres.2020.146901DOI Listing
September 2020