1,955 results match your criteria Brain Pathology[Journal]


Commentary to "A 44-year old female with familial Mediterranean fever, cardiomyopathy, and end stage renal disease" by Magaki et al.

Brain Pathol 2019 Feb 1. Epub 2019 Feb 1.

Pathology, Tenon Hospital, Paris, France.

We would like to comment on the "Case of the Month" by Magaki et al, entitled "A 44-year old female with familial Mediterranean fever, cardiomyopathy, and end stage renal disease" (3). In this case report, the authors describe the autopsy findings in a patient with systemic AA amyloidosis secondary to familial Mediterranean fever. The patient also had cardiomyopathy with severely reduced left ventricular ejection and death due to cardiac arrest; however, no details about cardiovascular risk factors, cardiac pre-mortem explorations, and heart gross examination were provided. Read More

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http://dx.doi.org/10.1111/bpa.12712DOI Listing
February 2019
1 Read

Dimethyl fumarate impairs differentiated B cells and fosters central nervous system integrity in treatment of multiple sclerosis.

Brain Pathol 2019 Jan 31. Epub 2019 Jan 31.

Institute of Neuropathology, University Medical Center, Göttingen, Germany.

In multiple sclerosis (MS), the effect of dimethyl fumarate (DMF) treatment is primarily attributed to its capacity to dampen pathogenic T cells. Here, we tested whether DMF also modulates B cells, which are newly recognized key players in MS, and to which extent DMF restricts ongoing loss of oligodendrocytes and axons in the central nervous system (CNS). Therefore, blood samples and brain tissue from DMF-treated MS patients were analyzed by flow cytometry or histopathological examination, respectively. Read More

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http://dx.doi.org/10.1111/bpa.12711DOI Listing
January 2019
1 Read

Oncogenic KRAS hotspot mutations are rare in IDH-mutant gliomas.

Brain Pathol 2019 Jan 24. Epub 2019 Jan 24.

Center for CNS Tumors, Comprehensive Cancer Center Tuebingen-Stuttgart, University Hospital of Tuebingen, Eberhard Karls University of Tuebingen, Tuebingen, Germany.

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http://doi.wiley.com/10.1111/bpa.12709
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http://dx.doi.org/10.1111/bpa.12709DOI Listing
January 2019
3 Reads

Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment.

Brain Pathol 2019 Jan 22. Epub 2019 Jan 22.

Neurolipid Biology, Instituto de Investigação e Inovação em Saúde - i3S, Instituto de Biologia Molecular e Celular - IBMC e Universidade do Porto, Porto, Portugal.

Plasmalogens are the most abundant form of ether-phospholipids in myelin and their deficiency causes Rhizomelic Chondrodysplasia Punctata (RCDP), a severe developmental disorder. Using the Gnpat knockout (KO) mouse as a model of RCDP, we determined the consequences of a plasmalogen deficiency during myelination and myelin homeostasis in the central nervous system (CNS). We unraveled that the lack of plasmalogens causes a generalized hypomyelination in several CNS regions including optic nerve, corpus callosum and spinal cord. Read More

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http://dx.doi.org/10.1111/bpa.12710DOI Listing
January 2019
1 Read

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice.

Brain Pathol 2019 Jan 20. Epub 2019 Jan 20.

Trinity College Institute for Neuroscience, Trinity College, Dublin 2, Ireland.

Among the changes that typify Alzheimer's disease (AD) are neuroinflammation and microglial activation, amyloid deposition perhaps resulting from compromised microglial function and iron accumulation. Data from Genome Wide Association Studies (GWAS) identified a number of gene variants that endow a significant risk of developing AD and several of these encode proteins expressed in microglia and proteins that are implicated in the immune response. This suggests that neuroinflammation and the accompanying microglial activation are likely to contribute to the pathogenesis of the disease. Read More

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http://doi.wiley.com/10.1111/bpa.12704
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http://dx.doi.org/10.1111/bpa.12704DOI Listing
January 2019
15 Reads

Axonal swelling and spheroids in Taenia solium neurocysticercosis.

Brain Pathol 2019 Jan 13. Epub 2019 Jan 13.

School of Medicine, Universidad Espíritu Santo - Ecuador, Samborondón, Ecuador.

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http://dx.doi.org/10.1111/bpa.12701DOI Listing
January 2019
2 Reads

Letter in response to Del Brutto, axonal swelling and spheroids in Taenia solium neurocysticercosis.

Brain Pathol 2019 Jan 13. Epub 2019 Jan 13.

Infectious Diseases Laboratory Research-LID, Faculty of Science and Philosophy, Alberto Cazorla Talleri, Universidad Peruana Cayetano Heredia, Lima, Perú.

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http://dx.doi.org/10.1111/bpa.12700DOI Listing
January 2019
3 Reads

Brain-derived and circulating vesicle profiles indicate neurovascular unit dysfunction in early Alzheimer's disease.

Brain Pathol 2019 Jan 10. Epub 2019 Jan 10.

School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.

Vascular factors that reduce blood flow to the brain are involved in apparition and progression of dementia. We hypothesized that cerebral hypoperfusion (CH) might alter the molecular compositions of brain intercellular communication mechanisms while affecting the neurovascular unit in preclinical and clinical human dementias. To test that hypothesis, mice were subjected to bilateral common carotid stenosis (BCAS) and the molecular compositions of brain-derived and circulating extracellular vesicles (EVs) were assessed. Read More

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http://dx.doi.org/10.1111/bpa.12699DOI Listing
January 2019
11 Reads

An Infratentorial Tumor in a 44-Year-Old Female Patient.

Brain Pathol 2019 01;29(1):145-146

Department of Neuropathology, University Hospital of Zurich.

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http://dx.doi.org/10.1111/bpa.12684DOI Listing
January 2019
1 Read

A 33-Year-Old Male with Five Years of Neck Pain.

Brain Pathol 2019 01;29(1):141-142

Department of Neurosurgery, University Hospital Essen, Germany.

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http://dx.doi.org/10.1111/bpa.12681DOI Listing
January 2019
1 Read

Two Male Infants each with a Cerebellar Mass.

Brain Pathol 2019 01;29(1):143-144

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul, Korea.

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http://dx.doi.org/10.1111/bpa.12683DOI Listing
January 2019
1 Read

Prion neurotoxicity.

Brain Pathol 2018 Dec 26. Epub 2018 Dec 26.

Department of Biochemistry, Boston University School of Medicine, Boston, MA.

Although the mechanisms underlying prion propagation and infectivity are now well established, the processes accounting for prion toxicity and pathogenesis have remained mysterious. These processes are of enormous clinical relevance as they hold the key to identification of new molecular targets for therapeutic intervention. In this review, we will discuss two broad areas of investigation relevant to understanding prion neurotoxicity. Read More

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http://dx.doi.org/10.1111/bpa.12694DOI Listing
December 2018
2 Reads

Recent advances in the histo-molecular pathology of human prion disease.

Brain Pathol 2018 Dec 26. Epub 2018 Dec 26.

IRCCS, Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Prion diseases are progressive neurodegenerative disorders affecting humans and other mammalian species. The term prion, originally put forward to propose the concept that a protein could be infectious, refers to PrP , a misfolded isoform of the cellular prion protein (PrP ) that represents the pathogenetic hallmark of these disorders. The discovery that other proteins characterized by misfolding and seeded aggregation can spread from cell to cell, similarly to PrP , has increased interest in prion diseases. Read More

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http://doi.wiley.com/10.1111/bpa.12695
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http://dx.doi.org/10.1111/bpa.12695DOI Listing
December 2018
8 Reads

Animal prion diseases: the risks to human health.

Brain Pathol 2018 Dec 26. Epub 2018 Dec 26.

UMR INRA ENVT 1225- IHAP, École Nationale Vétérinaire de Toulouse, Toulouse, France.

Transmissible spongiform encephalopathies (TSEs) or prion diseases of animals notably include scrapie in small ruminants, chronic wasting disease (CWD) in cervids and classical bovine spongiform encephalopathy (C-BSE). As the transmission barrier phenomenon naturally limits the propagation of prions from one species to another, and the lack of epidemiological evidence for an association with human prion diseases, the zoonotic potential of these diseases was for a long time considered negligible. However, in 1996, C-BSE was recognized as the cause of a new human prion disease, variant Creutzfeldt-Jakob disease (vCJD), which triggered an unprecedented public health crisis in Europe. Read More

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http://dx.doi.org/10.1111/bpa.12696DOI Listing
December 2018
1 Read

Recent advances on the molecular pathogenesis of prion diseases.

Brain Pathol 2018 Dec 26. Epub 2018 Dec 26.

Institute of Neuropathology, University Medical Center Hamburg-Eppendorf (UKE), 20246, Hamburg, Germany.

Prion diseases continue to fascinate scientists from different disciplines since the discovery that a misfolded prion protein can act as an infectious agent. Infectious prions have caused epidemics, including kuru in humans, cervid chronic wasting disease, bovine spongiform encephalopathy (BSE) or "mad cow disease", and most recently, camel prion disease, which was identified in 2018 (1). In Kuru, spread of the disease occurred from the ingestion of prion-infected, dead relatives as part of mourning practices, whereas in chronic wasting disease, prions may be transmitted not only through ingesting prion-contaminated food, but also by exposure to a prion-contaminated environment(8, 9). Read More

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http://dx.doi.org/10.1111/bpa.12693DOI Listing
December 2018
1 Read

Degeneration of dopaminergic circuitry influences depressive symptoms in Lewy body disorders.

Brain Pathol 2018 Dec 24. Epub 2018 Dec 24.

NIHR Biomedical Research Centre Newcastle, Biomedical Research Building, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK.

Aims: Depression is commonly observed even in prodromal stages of Lewy body disorders (LBD), and is associated with cognitive impairment and a faster rate of cognitive decline. Given the role of dopamine in the development of movement disorders, but also in motivation and reward, we investigated neurodegenerative pathology in dopaminergic circuitry in Parkinson's disease (PD), PD with dementia (PDD) and dementia with Lewy bodies (DLB) patients in relation to depressive symptoms.

Methods: α-synuclein, hyperphosphorylated tau and amyloid-beta pathology was assessed in 17 DLB, 14 PDD and 8 PD cases within striatal and midbrain subregions, with neuronal cell density assessed in substantia nigra and ventral tegmental area. Read More

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http://dx.doi.org/10.1111/bpa.12697DOI Listing
December 2018
2 Reads

27-hydroxycholesterol promotes Aβ accumulation via altering Aβ metabolism in mild cognitive impairment patients and APP/PS1 mice.

Brain Pathol 2018 Dec 23. Epub 2018 Dec 23.

School of Public Health, Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, China.

The oxysterol 27-hydroxycholesterol (27-OHC) has been considered to play a key role in the pathogenesis of Alzheimer's disease (AD). Because β-amyloid peptide (Aβ) is the pathological hallmark of AD, the aim of this study is to verify whether 27-OHC could lead to cognitive impairment through modulating Aβ accumulation and deposition. Regulation of Aβ metabolism was explored as the pathogenic mechanism of 27-OHC. Read More

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http://dx.doi.org/10.1111/bpa.12698DOI Listing
December 2018
2 Reads

A 39-year-old female with cerebellar tumor and visual disturbance.

Brain Pathol 2018 11;28(6):1027-1028

Department of Neurosurgery, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

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http://dx.doi.org/10.1111/bpa.12668DOI Listing
November 2018
2 Reads

Dear Reader: another changing of the guard.

Authors:

Brain Pathol 2018 11;28(6):789

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http://dx.doi.org/10.1111/bpa.12671DOI Listing
November 2018
1 Read

43 Year Old Woman with Left Arm Paralysis.

Brain Pathol 2018 11;28(6):1021-1022

Department of Neurology, Peking University People's Hospital, Beijing, China.

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http://dx.doi.org/10.1111/bpa.12665DOI Listing
November 2018
1 Read

A 72-year old female with multiple supra- and infratentorial dural masses.

Brain Pathol 2018 11;28(6):1023-1024

Institute of Neuropathology, University Hospital Zurich, Zurich, Switzerland.

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http://dx.doi.org/10.1111/bpa.12666DOI Listing
November 2018
1 Read
3.840 Impact Factor

An 83 year-old man with fever and speech difficulties.

Brain Pathol 2018 11;28(6):1025-1026

Division of Infectious Diseases, University of Colorado Denver, USA.

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http://dx.doi.org/10.1111/bpa.12667DOI Listing
November 2018
1 Read

Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas.

Brain Pathol 2018 Dec 3. Epub 2018 Dec 3.

Edinger Institute, Institute of Neurology, Goethe University Frankfurt, Frankfurt am Main, Germany.

While the central nervous system is considered an immunoprivileged site and brain tumors display immunosuppressive features, both innate and adaptive immune responses affect glioblastoma (GBM) growth and treatment resistance. However, the impact of the major immune cell population in gliomas, represented by glioma-associated microglia/macrophages (GAMs), on patients' clinical course is still unclear. Thus, we aimed at assessing the immunohistochemical expression of selected microglia and macrophage markers in 344 gliomas (including gliomas from WHO grade I-IV). Read More

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http://doi.wiley.com/10.1111/bpa.12690
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http://dx.doi.org/10.1111/bpa.12690DOI Listing
December 2018
14 Reads

Aberrant accrual of BIN1 near Alzheimer's disease amyloid deposits in transgenic models.

Brain Pathol 2018 Nov 30. Epub 2018 Nov 30.

Department of Neurobiology, The University of Chicago, Chicago, IL.

Bridging integrator 1 (BIN1) is the most significant late-onset Alzheimer's disease (AD) susceptibility locus identified via genome-wide association studies. BIN1 is an adaptor protein that regulates membrane dynamics in the context of endocytosis and membrane remodeling. An increase in BIN1 expression and changes in the relative levels of alternatively spliced BIN1 isoforms have been reported in the brains of patients with AD. Read More

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http://dx.doi.org/10.1111/bpa.12687DOI Listing
November 2018
6 Reads
3.840 Impact Factor

The sterol regulatory element-binding protein 2 is dysregulated by tau alterations in Alzheimer disease.

Brain Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Case Western Reserve University, Cleveland, OH.

Disturbed neuronal cholesterol homeostasis has been observed in Alzheimer disease (AD) and contributes to the pathogenesis of AD. As the master switch of cholesterol biosynthesis, the sterol regulatory element-binding protein 2 (SREBP-2) translocates to the nucleus after cleavage/activation, but its expression and activation have not been studied in AD which is the focus of the current study. We found both a significant decrease in the nuclear translocation of N-terminal SREBP-2 accompanied by a significant accumulation of C-terminal SREBP-2 in NFT-containing pyramidal neurons in AD. Read More

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http://dx.doi.org/10.1111/bpa.12691DOI Listing
December 2018
2 Reads

Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease.

Brain Pathol 2018 Dec 3. Epub 2018 Dec 3.

Department of Neurobiology and, Department of Neurology of the Second Affiliated Hospital, NHC and CAMS Key Laboratory of Medical Neurobiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310058, P.R. China.

Our previous studies showed that the transcription factor early growth response-1 (EGR1) may play a role in keeping the brain cholinergic function intact in the preclinical stages of Alzheimer's disease (AD). In order to elucidate the mechanisms involved, we first performed data mining on our previous microarray study on postmortem human prefrontal cortex (PFC) for the changes in the expression of EGR1 and acetylcholinesterase (AChE) and the relationship between them during the course of AD. The study contained 49 patients, ranging from non-demented controls (Braak stage 0) to late AD patients (Braak stage VI). Read More

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http://dx.doi.org/10.1111/bpa.12688DOI Listing
December 2018
2 Reads
3.840 Impact Factor

Extravascular fibrinogen in the white matter of Alzheimer's disease and normal aged brains: implications for fibrinogen as a biomarker for Alzheimer's disease.

Brain Pathol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.

The blood-brain barrier (BBB) regulates cerebrovascular permeability and leakage of blood-derived fibrinogen. Dysfunction of the BBB has been associated with cerebral arteriolosclerosis small vessel disease (SVD) and white matter lesions (WML). Furthermore, BBB dysfunction is associated with the pathogenesis of Alzheimer's disease (AD) with the presence of CSF plasma proteins suggested to be a potential biomarker of AD. Read More

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http://dx.doi.org/10.1111/bpa.12685DOI Listing
November 2018
5 Reads

Genotype-phenotype correlations in focal malformations of cortical development: a pathway to integrated pathological diagnosis in epilepsy surgery.

Brain Pathol 2018 Nov 28. Epub 2018 Nov 28.

Developmental Biology and Cancer Programme, UCL GOS Institute of Child Health, London, UK.

Malformations of cortical development (MCD) comprise a broad spectrum of developmental brain abnormalities. Patients presenting with MCDs often suffer from drug-resistant focal epilepsy, and some become candidates for epilepsy surgery. Their likelihood of achieving freedom from seizures, however, remains uncertain, and depends in a major part on the underlying pathology. Read More

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http://doi.wiley.com/10.1111/bpa.12686
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http://dx.doi.org/10.1111/bpa.12686DOI Listing
November 2018
6 Reads

Dysregulation of TDP-43 intracellular localization and early onset ALS are associated with a TARDBP S375G variant.

Brain Pathol 2018 Nov 21. Epub 2018 Nov 21.

International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy.

We investigated the Central Nervous System (CNS) and skeletal muscle tissue from A woman was clinically diagnosed with amyotrophic lateral sclerosis (ALS) at the age of 22. Neuropathologic evaluation showed upper and lower motor neuron loss, corticospinal tract degeneration and skeletal muscle denervation. Analysis of the patient's Deoxyribonucleic acid (DNA) revealed a AGT>GGT change resulting in an S375G substitution in the C-terminal region of TDP-43. Read More

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http://dx.doi.org/10.1111/bpa.12680DOI Listing
November 2018
9 Reads

Genome-wide identification of microRNAs regulating the human prion protein.

Brain Pathol 2018 Nov 19. Epub 2018 Nov 19.

Institute of Neuropathology, University of Zürich, Zürich, Switzerland.

The cellular prion protein (PrP ) is best known for its misfolded disease-causing conformer, PrP . Because the availability of PrP is often limiting for prion propagation, understanding its regulation may point to possible therapeutic targets. We sought to determine to what extent the human microRNAome is involved in modulating PrP levels through direct or indirect pathways. Read More

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http://doi.wiley.com/10.1111/bpa.12679
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http://dx.doi.org/10.1111/bpa.12679DOI Listing
November 2018
8 Reads

Clarity reveals a more protracted temporal course of axon swelling and disconnection than previously described following traumatic brain injury.

Brain Pathol 2018 Nov 16. Epub 2018 Nov 16.

Department of Neurosurgery, Penn Center for Brain Injury and Repair, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Diffuse axonal injury (DAI) is an important consequence of traumatic brain injury (TBI). At the moment of trauma, axons rarely disconnect, but undergo cytoskeletal disruption and transport interruption leading to protein accumulation within swellings. The amyloid precursor protein (APP) accumulates rapidly and the standard histological evaluation of axonal pathology relies upon its detection. Read More

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http://doi.wiley.com/10.1111/bpa.12677
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http://dx.doi.org/10.1111/bpa.12677DOI Listing
November 2018
15 Reads

Oligodendroglial α-synucleinopathy-driven neuroinflammation in multiple system atrophy.

Brain Pathol 2018 Nov 16. Epub 2018 Nov 16.

Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Neuroinflammation and oligodendroglial cytoplasmic α-synuclein (α-syn) inclusions (GCIs) are important neuropathological characteristics of multiple system atrophy (MSA). GCIs are known to interfere with oligodendroglial maturation and consequently result in myelin loss. The neuroinflammatory phenotype in the context of MSA, however, remains poorly understood. Read More

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http://doi.wiley.com/10.1111/bpa.12678
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http://dx.doi.org/10.1111/bpa.12678DOI Listing
November 2018
18 Reads

Clinicopathologic features of anaplastic myxopapillary ependymomas.

Brain Pathol 2019 01;29(1):75-84

Department of Pathology, University of California, San Francisco, CA.

Myxopapillary ependymomas (MPE) are considered benign (World Health Organization (WHO) grade I) neoplasms with favorable prognosis. However, malignant behavior occurs in a small subset. To our knowledge, only five anaplastic MPEs have been reported without consensus on diagnostic criteria. Read More

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http://doi.wiley.com/10.1111/bpa.12673
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http://dx.doi.org/10.1111/bpa.12673DOI Listing
January 2019
10 Reads
3.840 Impact Factor

Regulation of glioma cell invasion by 3q26 gene products PIK3CA, SOX2 and OPA1.

Brain Pathol 2018 Nov 7. Epub 2018 Nov 7.

Laboratory of Brain Tumor Biology, Department of Biomedicine, University Hospital and University of Basel, Basel, Switzerland.

Diffuse gliomas progress by invading neighboring brain tissue to promote postoperative relapse. Transcription factor SOX2 is highly expressed in invasive gliomas and maps to chromosome region 3q26 together with the genes for PI3K/AKT signaling activator PIK3CA and effector molecules of mitochondria fusion and cell invasion, MFN1 and OPA1. Gene copy number analysis at 3q26 from 129 glioma patient biopsies revealed mutually exclusive SOX2 amplifications (26%) and OPA1 losses (19%). Read More

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http://doi.wiley.com/10.1111/bpa.12670
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http://dx.doi.org/10.1111/bpa.12670DOI Listing
November 2018
11 Reads

Myelin water imaging to detect demyelination and remyelination and its validation in pathology.

Brain Pathol 2018 09;28(5):750-764

Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Damage to myelin is a key feature of multiple sclerosis (MS) pathology. Magnetic resonance imaging (MRI) has revolutionized our ability to detect and monitor MS pathology in vivo. Proton density, T and T can provide qualitative contrast weightings that yield superb in vivo visualization of central nervous system tissue and have proved invaluable as diagnostic and patient management tools in MS. Read More

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http://doi.wiley.com/10.1111/bpa.12645
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http://dx.doi.org/10.1111/bpa.12645DOI Listing
September 2018
5 Reads

66 Year-Old Woman With Muscle Weakness And Respiratory Failure.

Brain Pathol 2018 09;28(5):775-776

Pathology Department (Neuropathology Division) at Hospital, Universitario Central de Asturias, Oviedo, Spain.

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http://dx.doi.org/10.1111/bpa.12652DOI Listing
September 2018
2 Reads

A 66-year-old woman with progressive dementia.

Brain Pathol 2018 09;28(5):779-781

Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1111/bpa.12654DOI Listing
September 2018
1 Read

Magnetic resonance imaging correlates of neuro-axonal pathology in the MS spinal cord.

Brain Pathol 2018 09;28(5):765-772

Barts Health NHS Trust, Clinical Physics, London, UK.

In people with multiple sclerosis (MS), the spinal cord is the structure most commonly affected by clinically detectable pathology at presentation, and a key part of the central nervous system involved in chronic disease deterioration. Indices, such as the spinal cord cross-sectional area at the level C have been developed as tools to predict future disability, and-by inference-axonal loss. However, this and other histo-pathological correlates of spinal cord magnetic resonance imaging (MRI) changes in MS remain incompletely understood. Read More

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http://dx.doi.org/10.1111/bpa.12648DOI Listing
September 2018
8 Reads

A 3-Month-Old Boy With Progressive Weakness.

Brain Pathol 2018 09;28(5):773-774

Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Korea.

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http://doi.wiley.com/10.1111/bpa.12651
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http://dx.doi.org/10.1111/bpa.12651DOI Listing
September 2018
7 Reads

Multiple Sclerosis Pathology and its Reflection by Imaging Technologies: Introduction.

Authors:
Hans Lassmann

Brain Pathol 2018 09;28(5):721-722

Center for Brain Research, Medical University of Vienna, Wien, Austria.

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http://dx.doi.org/10.1111/bpa.12649DOI Listing
September 2018
2 Reads

Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis.

Brain Pathol 2018 Oct 28. Epub 2018 Oct 28.

Infectious Diseases Laboratory Research-LID, Faculty of Science and Philosophy, Alberto Cazorla Talleri, Universidad Peruana Cayetano Heredia, Lima, Perú.

Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of Taenia solium and is the leading cause of preventable epilepsy worldwide. However, the pathophysiology and relation to the wide range of clinical features remains poorly understood. Axonal swelling is emerging as an important early pathological finding in multiple neurodegenerative diseases and as a cause of brain injury, but has not been well described in neurocysticercosis. Read More

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http://doi.wiley.com/10.1111/bpa.12669
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http://dx.doi.org/10.1111/bpa.12669DOI Listing
October 2018
32 Reads
3.840 Impact Factor

Subicular hypotrophy in fetuses with Down syndrome and in the Ts65Dn model of Down syndrome.

Brain Pathol 2018 Oct 16. Epub 2018 Oct 16.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Intellectual disability in Down syndrome (DS) has been attributed to neurogenesis impairment during fetal brain development. Consistently with explicit memory alterations observed in children with DS, fetuses with DS exhibit neurogenesis impairment in the hippocampus, a key region involved in memory formation and consolidation. Recent evidence suggests that the subiculum plays a unique role in memory retrieval, a process that is also altered in DS. Read More

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http://doi.wiley.com/10.1111/bpa.12663
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http://dx.doi.org/10.1111/bpa.12663DOI Listing
October 2018
13 Reads

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging.

Brain Pathol 2018 Oct 16. Epub 2018 Oct 16.

Department of Neuropathology, Sainte-Anne Hospital, Paris, France.

Ependymoma with RELA fusion has been defined as a novel entity of the revised World Health Organization 2016 classification of tumors of the central nervous system (CNS), characterized by fusion transcripts of the RELA gene and consequent pathological activation of the NFkB pathway. These tumors represent the majority of supratentorial ependymomas in children. The validation of diagnostic tools to identify this clinically relevant ependymoma entity is essential. Read More

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http://dx.doi.org/10.1111/bpa.12664DOI Listing
October 2018
5 Reads

Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence.

Brain Pathol 2018 Oct 10. Epub 2018 Oct 10.

Department of (Neuro-)Pathology, Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience, Meibergdreef 9, Amsterdam, the Netherlands.

Oxidative stress (OS) occurs in brains of patients with epilepsy and coincides with brain inflammation, and both phenomena contribute to seizure generation in animal models. We investigated whether expression of OS and brain inflammation markers co-occurred also in resected brain tissue of patients with epileptogenic cortical malformations: hemimegalencephaly (HME), focal cortical dysplasia (FCD) and cortical tubers in tuberous sclerosis complex (TSC). Moreover, we studied molecular mechanisms linking OS and inflammation in an in vitro model of neuronal function. Read More

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http://doi.wiley.com/10.1111/bpa.12661
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http://dx.doi.org/10.1111/bpa.12661DOI Listing
October 2018
9 Reads

Clusterin contributes to early stage of Alzheimer's disease pathogenesis.

Brain Pathol 2018 Oct 8. Epub 2018 Oct 8.

Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.

While clusterin is reportedly involved in Alzheimer's disease (AD) pathogenesis, how clusterin interacts with amyloid-β (Aß) to cause Aß neurotoxicity remains unclear in vivo. Using 5×FAD transgenic mice, which develop robust AD pathology and memory deficits when very young, we detected interactions between clusterin and Aß in the mouse brains. The two proteins were concurrently upregulated and bound or colocalized with each other in the same complexes or in amyloid plaques. Read More

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http://dx.doi.org/10.1111/bpa.12660DOI Listing
October 2018
4 Reads

Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features.

Brain Pathol 2018 Sep 23. Epub 2018 Sep 23.

Institute of Neuropathology, University of Bonn Medical Center, Bonn, Germany.

Ependymoma with YAP1-MAMLD1 fusion is a rare, recently described supratentorial neoplasm of childhood, with few cases published so far. We report on 15 pediatric patients with ependymomas carrying YAP1-MAMLD1 fusions, with their characteristic histopathology, immunophenotype and molecular/cytogenetic, radiological and clinical features. The YAP1-MAMLD1 fusion was documented by RT-PCR/Sanger sequencing, and tumor genomes were studied by molecular inversion probe (MIP) analysis. Read More

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http://dx.doi.org/10.1111/bpa.12659DOI Listing
September 2018
20 Reads
3.840 Impact Factor

Granular cell astrocytoma: an aggressive IDH-wildtype diffuse glioma with molecular genetic features of primary glioblastoma.

Brain Pathol 2018 Sep 17. Epub 2018 Sep 17.

Department of Pathology, Johns Hopkins University, Baltimore, MD.

Granular cell astrocytoma (GCA) is a rare adult infiltrating glioma subtype. We studied a series of 39 GCAs. Median age of presentation was 57. Read More

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http://doi.wiley.com/10.1111/bpa.12657
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http://dx.doi.org/10.1111/bpa.12657DOI Listing
September 2018
2 Reads

Deep cervical lymph node ligation aggravates AD-like pathology of APP/PS1 mice.

Brain Pathol 2018 Sep 7. Epub 2018 Sep 7.

Jiangsu Province, Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing, Jiangsu, China.

The imbalance between production and clearance of amyloid-beta (Aβ) is a key step in the onset and development of Alzheimer's disease (AD). Therefore, reducing Aβ accumulation in the brain is a promising therapeutic strategy for AD. The recently discovered glymphatic system and meningeal lymphatic vasculature have been shown to be critical for the elimination of interstitial waste products, especially Aβ, from the brain. Read More

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http://doi.wiley.com/10.1111/bpa.12656
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http://dx.doi.org/10.1111/bpa.12656DOI Listing
September 2018
14 Reads

Alternative lengthening of telomeres, ATRX loss and H3-K27M mutations in histologically defined pilocytic astrocytoma with anaplasia.

Brain Pathol 2019 01 17;29(1):126-140. Epub 2018 Oct 17.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Anaplasia may be identified in a subset of tumors with a presumed pilocytic astrocytoma (PA) component or piloid features, which may be associated with aggressive behavior, but the biologic basis of this change remains unclear. Fifty-seven resections from 36 patients (23 M, 13 F, mean age 32 years, range 3-75) were included. A clinical diagnosis of NF1 was present in 8 (22%). Read More

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http://dx.doi.org/10.1111/bpa.12646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314894PMC
January 2019
8 Reads