4,968 results match your criteria Brain Metastasis Imaging


Early postoperative MRI after resection of brain metastases-complete tumour resection associated with prolonged survival.

Acta Neurochir (Wien) 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark.

Background: This study aimed to investigate the incidence of residual tumour after resection of brain metastases using early postoperative magnetic resonance imaging (MRI) and the influence of residual tumour on overall patient survival.

Methods: Data from 72 consecutive adult patients undergoing surgery for cerebral metastases over an 18-month study period were retrospectively collected. Early postoperative MRI was used to determine the presence of postoperative residual tumour. Read More

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http://dx.doi.org/10.1007/s00701-019-03829-0DOI Listing
February 2019

Cellular MRI Reveals Altered Brain Arrest of Genetically Engineered Metastatic Breast Cancer Cells.

Contrast Media Mol Imaging 2019 8;2019:6501231. Epub 2019 Jan 8.

Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada.

Purpose: The combined use of anatomical magnetic resonance imaging (MRI), cellular MRI, and bioluminescence imaging (BLI) allows for sensitive and improved monitoring of brain metastasis in preclinical cancer models. By using these complementary technologies, we can acquire measurements of viable single cell arrest in the brain after systemic administration, the clearance and/or retention of these cells thereafter, the growth into overt tumours, and quantification of tumour volume and relative cancer cell viability over time. While BLI is very useful in measuring cell viability, some considerations have been reported using cells engineered with luciferase such as increased tumour volume variation, changes in pattern of metastatic disease, and inhibition of tumour growth. Read More

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http://dx.doi.org/10.1155/2019/6501231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348811PMC
January 2019

Alpha particle Radium 223 dichloride in high-risk osteosarcoma: a phase I dose escalation trial.

Clin Cancer Res 2019 Feb 7. Epub 2019 Feb 7.

Radiology, Baylor College of Medicine.

Purpose: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (RaCl) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers.

Experimental Design: A 3+3 phase I, dose-escalation trial of RaCl (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3964DOI Listing
February 2019
1 Read

The RANO Leptomeningeal Metastasis Group proposal to assess response to treatment: lack of feasibility and clinical utility, and a revised proposal.

Neuro Oncol 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurology & Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.

Background: A scorecard to evaluate magnetic resonance imaging (MRI) findings during the course of leptomeningeal metastases (LM) has been proposed by the Response Assessment in Neuro-Oncology (RANO) group.

Methods: To explore the feasibility of the LANO scorecard, cerebrospinal MRI of 22 patients with LM from solid tumors were scored by 10 neuro-oncologists and 9 neuroradiologists at baseline and at follow-up after treatment. Raters were blinded for clinical data including treatment. Read More

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http://dx.doi.org/10.1093/neuonc/noz024DOI Listing
January 2019
1 Read

Abscess Formation in Metastatic Brain Tumor with History of Immune Checkpoint Inhibitor: A Case Report.

NMC Case Rep J 2019 Jan 18;6(1):11-15. Epub 2018 Dec 18.

Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan.

We present the case of a 68-year-old man with brain metastasis from lung cancer and a history of immune checkpoint inhibitor administration, with overlapping abscess within the metastatic lesion. He initially received antibiotic treatment under a diagnosis of brain abscess because of a hyper-intense area on diffusion-weighted imaging inside the gadolinium-enhanced wall. The size of the enhanced lesion did not change much, but the extent of perifocal edema decreased after antibiotic treatment. Read More

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http://dx.doi.org/10.2176/nmccrj.cr.2018-0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350031PMC
January 2019
1 Read

M1b Disease in the 8th Edition of TNM Staging of Lung Cancer: Pattern of Single Extrathoracic Metastasis and Clinical Outcome.

Oncologist 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Background: The 8th edition of TNM staging of non-small cell lung cancer (NSCLC) has revised M classification and defined M1b disease with single extrathoracic metastasis, which is distinguished from M1c with multiple extrathoracic metastases. We investigated the prevalence, characteristics, and overall survival (OS) of M1b disease in patients with stage IV NSCLC.

Methods: The study reviewed the medical records and imaging studies of 567 patients with stage IV NSCLC to determine M stage using the 8th edition of TNM staging. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0596DOI Listing
January 2019

The genomic imprint of cancer therapies helps timing the formation of metastases.

Int J Cancer 2019 Jan 29. Epub 2019 Jan 29.

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.

A retrospective determination of the time of metastasis formation is essential for a better understanding of the evolution of oligometastatic cancer. This study was based on the hypothesis that genomic alterations induced by cancer therapies could be used to determine the temporal order of the treatment and the formation of metastases. We analysed the whole genome sequence of a primary tumour sample and three metastatic sites derived from autopsy samples from a young never-smoker lung adenocarcinoma patient with an activating EGFR mutation. Read More

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http://doi.wiley.com/10.1002/ijc.32159
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http://dx.doi.org/10.1002/ijc.32159DOI Listing
January 2019
4 Reads

[Leptomeningeal metastasis of EGFR (+) lung adenocarcinoma: a case report].

Tuberk Toraks 2018 Dec;66(4):340-344

Division of Chest Diseases, University of Health Sciences, Dr. Suat Seren Chest Diseases and Chest Surgery Training and Research Hospital, Izmir, Turkey.

Leptomeningeal metastasis is a very rare complication of infiltration of leptomeninges and subarachnoid space with malignant cells. It is an indicator of poor prognosis. Its incidence is 3. Read More

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http://dx.doi.org/10.5578/tt.67609DOI Listing
December 2018
3 Reads

Brain metastasis in pancreatic cancer: Two case reports.

Medicine (Baltimore) 2019 Jan;98(4):e14227

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo.

Rationale: Brain metastases are extremely rare for patients with pancreatic adenocarcinoma due to the poor prognoses. In the present study, we reported 2 cases of pancreatic adenocarcinoma with brain metastases.

Patient Concerns: The 1st patient was diagnosed asymptomatic brain metastasis by a follow-up brain magnetic resonance imaging (MRI) due to a medical history of subarachnoid hemorrhage. Read More

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http://dx.doi.org/10.1097/MD.0000000000014227DOI Listing
January 2019

Tumour pH and protein concentration contribute to the signal of amide proton transfer magnetic resonance imaging.

Cancer Res 2019 Jan 24. Epub 2019 Jan 24.

ONCOLOGY, University of Oxford

Abnormal pH is a common feature of malignant tumours and has been associated clinically with sub-optimal outcomes. Amide proton transfer magnetic resonance imaging (APT MRI) holds promise as a means to non-invasively measure tumour pH, yet multiple factors collectively make quantification of tumour pH from APT MRI data challenging. The purpose of this study was to improve our understanding of the biophysical sources of altered APT MRI signals in tumours. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2168DOI Listing
January 2019

Detecting recurrent ovarian cancer: revisit the values of whole-body CT and serum CA 125 levels.

Acta Radiol 2019 Jan 24:284185118822649. Epub 2019 Jan 24.

1 Department of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan, Taiwan.

Background: Computed tomography (CT) has served as the first-line imaging modality but its role for detecting recurrent ovarian cancer should be revisited in the era of whole-body CT.

Purpose: To study anatomical distributions and imaging patterns of recurrent ovarian epithelial cancer through whole-body CT and their associations with serum cancer antigen 125 (CA 125) levels.

Material And Methods: This retrospective study approved by the institutional review board comprised a cohort of 497 patients with ovarian cancer. Read More

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http://dx.doi.org/10.1177/0284185118822649DOI Listing
January 2019
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Distribution of metastasis in the brain in relation to the hippocampus: a retrospective single-center analysis of 565 metastases in 116 patients.

Cancer Imaging 2019 Jan 22;19(1). Epub 2019 Jan 22.

Department of Radiation Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233004, China.

Objective: To examine the distribution of brain metastases (BM) in relation to the hippocampus, so as to determine the risk of metastasis in the hippocampus, and thus provide experimental evidence for the hippocampal avoidance (HA) in patients with BM during radiotherapy.

Methods: (1) For the retrospective analysis of 116 patients diagnosed with malignancies, confirmed as BM, from December 2014 to December 2016 at the First Affiliated Hospital of Bengbu Medical College. We obtained the T1-weighted, postcontrast axial, sagittal, and coronal Magnetic Resonance imaging (MRI) images f the patients, in supine position, using the head restraints and head thermoplastic masks to adjust the positioning, with computed tomography (CT) positioning scan ranging from the head to the mandible (layer thickness: 3 mm). Read More

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http://dx.doi.org/10.1186/s40644-019-0188-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341547PMC
January 2019
1 Read
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Demyelinating lesions behaving like aggressive tumours on advanced MRI techniques.

Neuroradiol J 2019 Jan 22:1971400919826394. Epub 2019 Jan 22.

4 Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, USA.

Tumefactive demyelinating lesions are a rare disorder in which inflammatory demyelination manifests as solitary or multiple focal brain lesions (greater than 2 cm in size), which can be mistaken for glioma, lymphoma, metastasis and in some cases even brain abscess. The symptomatology of tumefactive demyelinating lesions depends on the white matter area involved and includes quickly progressing neurological deterioration of motor, sensory and visual function, praxis, language and mood impairment, as well as seizures. Recognising the key imaging features in a patient with a prior history of demyelination may expedite appropriate management. Read More

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http://dx.doi.org/10.1177/1971400919826394DOI Listing
January 2019
3 Reads

Prophylactic cranial irradiation in small cell lung cancer: a systematic review and meta-analysis.

BMC Cancer 2019 Jan 21;19(1):95. Epub 2019 Jan 21.

Department of Radiation Oncology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, People's Republic of China.

Background: The efficacy of prophylactic cranial irradiation (PCI) in treating patients with small cell lung cancer (SCLC) has not been clear, and recent randomized studies have demonstrated conflicting results from previously published findings. The purpose of this study was to reevaluate the efficacy of PCI in patients with SCLC and to assess factors associated with its efficacy.

Methods: We conducted a quantitative meta-analysis to explore the efficacy of PCI in patients with SCLC. Read More

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http://dx.doi.org/10.1186/s12885-018-5251-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341615PMC
January 2019

Nanoliposome targeting in breast cancer is influenced by the tumor microenvironment.

Nanomedicine 2019 Jan 14;17:71-81. Epub 2019 Jan 14.

Merrimack Pharmaceuticals, Inc., Cambridge, MA, USA. Electronic address:

MM-302 is an anti-HER2 antibody-targeted pegylated liposomal doxorubicin designed to deliver doxorubicin specifically to HER2-expressing solid tumors. The delivery and activity of MM-302 were evaluated in orthotopic, transgenic, and intravenous breast cancer models expressing varying levels of HER2 that metastasize to some of the most common sites of dissemination for breast cancer, namely, lung, liver, and brain. Metastatic burden was quantified by gross evaluation, immunohistochemistry (IHC), and bioluminescent imaging. Read More

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http://dx.doi.org/10.1016/j.nano.2018.12.010DOI Listing
January 2019
2 Reads

Brain metastasis from ovarian clear cell carcinoma: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14020

Department of Oncology, Xiang Ya Hospital, Central South University, China.

Rationale: Epithelial ovarian carcinoma (EOC) is the most common type of ovarian carcinoma, and the leading cause of female genital tract cancer-related deaths. However, brain metastasis (BM) of EOC is rare, with an incidence of only 1% to 2%. Ovarian clear cell carcinoma (OCCC), accounting for 5% to 25% of all EOC cases, has a poor prognosis compared with other epithelial cell type carcinomas. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901180-0002
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http://dx.doi.org/10.1097/MD.0000000000014020DOI Listing
January 2019
3 Reads

Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis.

Oncogene 2019 Jan 16. Epub 2019 Jan 16.

Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.

Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experiments, we determined invadopodia contain receptors involved in chemotaxis, namely GABA receptor and EGFR. These chemotaxis capabilities are mediated in part by PAK1 which controls invadopodia responsiveness to ligands such as GABA and EGF via assembly, stability, and turnover of invadopodia in vivo. Read More

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http://dx.doi.org/10.1038/s41388-018-0667-4DOI Listing
January 2019

Incidence of Hippocampal Metastases: Laterality and Implications for Unilateral Hippocampal Avoiding Whole Brain Radiotherapy.

Biomed Res Int 2018 13;2018:2459608. Epub 2018 Dec 13.

Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic.

Introduction: Hippocampi sparing whole brain radiotherapy (WBRT) is an evolving approach in the treatment of patients with multiple brain metastases, pursuing mitigation of verbal memory decline as a consequence of hippocampal radiation injury. Accumulating data are showing different postradiotherapy changes in the left and right hippocampus with a theoretical proposal of only unilateral (dominant, left) hippocampal sparing during WBRT.

Method: The aim of this retrospective study is to describe spatial distribution of brain metastases on MRI in a cohort of 260 patients (2595 metastases) and to evaluate distribution separately in the left and right hippocampus and in respective hippocampal avoiding zones (HAZ, region with subtherapeutic radiation dose), including evaluation of location of metastatic mass centre. Read More

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http://dx.doi.org/10.1155/2018/2459608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311293PMC
December 2018

Synchronous cerebral arteriovenous malformation and lung adenocarcinoma carcinoma brain metastases: A case study and literature review.

Neurochirurgie 2019 Jan 9. Epub 2019 Jan 9.

Department of Surgery, Division of Neurosurgery, University of Connecticut Health, Farmington, Connecticut, 06032, USA. Electronic address:

Introduction: While there are numerous published cases of arteriovenous malformations (AVMs) developing in the setting of malignancy, it is extremely rare to find them concurrently associated in the brain.

Clinical Case: This is the case of a 55-year-old male who presented to the emergency department complaining of headaches, memory and visual changes. Neuro-imaging revealed a right temporal parietal AVM and an adjoining hyperenhancing occipitotemporal lobe lesion with concern for a possible evolving stroke. Read More

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http://dx.doi.org/10.1016/j.neuchi.2018.07.003DOI Listing
January 2019
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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.

Authors:
Clotilde Théry Kenneth W Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K Atkin-Smith D Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N Bauer Amy A Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E Borràs Steffi Bosch Chantal M Boulanger Xandra Breakefield Andrew M Breglio Meadhbh Á Brennan David R Brigstock Alain Brisson Marike Ld Broekman Jacqueline F Bromberg Paulina Bryl-Górecka Shilpa Buch Amy H Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I Buzás James Bryan Byrd Giovanni Camussi David Rf Carter Sarah Caruso Lawrence W Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R Chin Aled Clayton Stefano P Clerici Alex Cocks Emanuele Cocucci Robert J Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank Aw Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D'Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de Candia Eliezer F De Santana Olivier De Wever Hernando A Del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R Dourado Tom Ap Driedonks Filipe V Duarte Heather M Duncan Ramon M Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M Falcón-Pérez Farah Fatima Jason E Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah Ci Goberdhan André Görgens Sharon M Gorski David W Greening Julia Christina Gross Alice Gualerzi Gopal N Gupta Dakota Gustafson Aase Handberg Reka A Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F Hill Fred H Hochberg Karl F Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M Inal Mustafa Isin Alena Ivanova Hannah K Jackson Soren Jacobsen Steven M Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M Johnson Jennifer C Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-Ichi Kano Sukhbir Kaur Yumi Kawamura Evan T Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J Klinke Miroslaw Kornek Maja M Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V Kurochkin Gina D Kusuma Sören Kuypers Saara Laitinen Scott M Langevin Lucia R Languino Joanne Lannigan Cecilia Lässer Louise C Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S Lemos Metka Lenassi Aleksandra Leszczynska Isaac Ts Li Ke Liao Sten F Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine A Lombard Magdalena J Lorenowicz Ákos M Lörincz Jan Lötvall Jason Lovett Michelle C Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral R Lunavat Sybren Ln Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S Martens-Uzunova Lorena Martin-Jaular M Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K McGinnis Mark J McVey David G Meckes Katie L Meehan Inge Mertens Valentina R Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C Muth Kathryn H Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P Nolan Esther Nm Nolte-'t Hoen Nicole Noren Hooten Lorraine O'Driscoll Tina O'Grady Ana O'Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park D Michiel Pegtel Hector Peinado Francesca Perut Michael W Pfaffl Donald G Phinney Bartijn Ch Pieters Ryan C Pink David S Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan Kh Poon Bonita H Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L Raffai Stefania Raimondo Janusz Rak Marcel I Ramirez Graça Raposo Morsi S Rayyan Neta Regev-Rudzki Franz L Ricklefs Paul D Robbins David D Roberts Silvia C Rodrigues Eva Rohde Sophie Rome Kasper Ma Rouschop Aurelia Rughetti Ashley E Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A Saugstad Meike J Saul Raymond M Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K Shetty Kiyotaka Shiba Pia R-M Siljander Andreia M Silva Agata Skowronek Orman L Snyder Rodrigo Pedro Soares Barbara W Sódar Carolina Soekmadji Javier Sotillo Philip D Stahl Willem Stoorvogel Shannon L Stott Erwin F Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bas Wm van Balkom Susanne G van der Grein Jan Van Deun Martijn Jc van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E van Royen Andre J van Wijnen M Helena Vasconcelos Ivan J Vechetti Tiago D Veit Laura J Vella Émilie Velot Frederik J Verweij Beate Vestad Jose L Viñas Tamás Visnovitz Krisztina V Vukman Jessica Wahlgren Dionysios C Watson Marca Hm Wauben Alissa Weaver Jason P Webber Viktoria Weber Ann M Wehman Daniel J Weiss Joshua A Welsh Sebastian Wendt Asa M Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-Ye Zhang Zezhou Zhao Lei Zheng Alexander R Zheutlin Antje M Zickler Pascale Zimmermann Angela M Zivkovic Davide Zocco Ewa K Zuba-Surma

J Extracell Vesicles 2018 23;7(1):1535750. Epub 2018 Nov 23.

Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Department of Cell Biology, Kraków, Poland.

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles ("MISEV") guidelines for the field in 2014. Read More

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https://www.tandfonline.com/doi/full/10.1080/20013078.2018.1
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http://dx.doi.org/10.1080/20013078.2018.1535750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322352PMC
November 2018
27 Reads

Differentiation between glioblastoma, brain metastasis and subtypes using radiomics analysis.

J Magn Reson Imaging 2019 Jan 11. Epub 2019 Jan 11.

Sagol Brain Institute, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Differentiation between glioblastoma and brain metastasis is highly important due to differing medical treatment strategies. While MRI is the modality of choice for the assessment of patients with brain tumors, differentiation between glioblastoma and solitary brain metastasis may be challenging due to their similar appearance on MRI.

Purpose: To differentiate between glioblastoma and brain metastasis subtypes using radiomics analysis based on conventional post-contrast T -weighted (T W) MRI. Read More

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http://dx.doi.org/10.1002/jmri.26643DOI Listing
January 2019
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Prospective comparison of (4S)-4-(3-F-fluoropropyl)-L-glutamate versus F-fluorodeoxyglucose PET/CT for detecting metastases from pancreatic ductal adenocarcinoma: a proof-of-concept study.

Eur J Nucl Med Mol Imaging 2019 Jan 11. Epub 2019 Jan 11.

Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, 7 Chung-Shan South Rd., Taipei, 10002, Taiwan, Republic of China.

Purpose: (4S)-4-(3-F-Fluoropropyl)-L-glutamate (FSPG) positron emission tomography (PET) reflects system x transporter (xCT) expression. FSPG PET has been used to detect brain, lung, breast and liver cancer with only modest success. There is no report on the use of FSPG PET in pancreatic ductal adenocarcinoma (PDAC), presumably because of normal xCT expression in the pancreas. Read More

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http://dx.doi.org/10.1007/s00259-018-4251-5DOI Listing
January 2019
1 Read

Tissue-type mapping of gliomas.

Neuroimage Clin 2018 Dec 25:101648. Epub 2018 Dec 25.

Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address:

Purpose: To develop a statistical method of combining multimodal MRI (mMRI) of adult glial brain tumours to generate tissue heterogeneity maps that indicate tumour grade and infiltration margins.

Materials And Methods: We performed a retrospective analysis of mMRI from patients with histological diagnosis of glioma (n = 25). H Magnetic Resonance Spectroscopic Imaging (MRSI) was used to label regions of "pure" low- or high-grade tumour across image types. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.101648DOI Listing
December 2018
1 Read

Solitary CNS Metastasis on Initial Presentation of High Grade Serous Carcinoma of the Fallopian Tube.

Case Rep Obstet Gynecol 2018 5;2018:6930986. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

A 68-year-old woman presented with a three-week history of confusion and anomic aphasia. Imaging of her head demonstrated a single large left frontal mass. Pathology revealed metastatic adenocarcinoma of Müllerian origin. Read More

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http://dx.doi.org/10.1155/2018/6930986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304521PMC
December 2018
1 Read

Long-term characterization of activated microglia/macrophages facilitating the development of experimental brain metastasis through intravital microscopic imaging.

J Neuroinflammation 2019 Jan 7;16(1). Epub 2019 Jan 7.

Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Room G304, Wuhan, 430074, Hubei, China.

Background: Microglia/macrophages (M/Ms) with multiple functions derived from distinct activation states are key surveillants maintaining brain homeostasis. However, their activation status and role during the brain metastasis of malignant tumors have been poorly characterized.

Methods: Heterozygous CX3CR1-GFP transgenic mice were used to visualize the dynamic changes of M/Ms during the development of experimental brain metastasis through long-term intravital imaging equipped with redesigned bilateral cranial windows. Read More

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http://dx.doi.org/10.1186/s12974-018-1389-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323850PMC
January 2019
1 Read

PET Imaging in Patients with Brain Metastasis - Report of the RANO/PET Group.

Neuro Oncol 2019 Jan 5. Epub 2019 Jan 5.

Dept. of Neurosurgery, Ludwig Maximilians-University of Munich, Munich, Germany.

Brain metastases (BM) from extracranial cancer are associated with significant morbidity and mortality. Effective local treatment options are stereotactic radiotherapy, including radiosurgery or fractionated external beam radiotherapy, and surgical resection. The use of systemic treatment for intracranial disease control also is improving. Read More

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https://academic.oup.com/neuro-oncology/advance-article/doi/
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http://dx.doi.org/10.1093/neuonc/noz003DOI Listing
January 2019
4 Reads

Prognostic value and impact of cerebral metastases in pancreatic cancer.

Acta Chir Belg 2019 Jan 7:1-5. Epub 2019 Jan 7.

a Department of General and Visceral Surgery , St. Josef-Hospital, Ruhr-University Bochum , Bochum , Germany.

Background: Pancreatic cancer is a fatal disease most often diagnosed at an advanced stage. Most patients already suffer from irresectable tumor or distant metastases being most commonly found in the liver or the lung. However, cerebral metastases occur extremely rare. Read More

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http://dx.doi.org/10.1080/00015458.2018.1549379DOI Listing
January 2019
3 Reads

Ventral Brainstem Anatomy: An Endoscopic Transoral Perspective.

Acta Neurochir Suppl 2019 ;125:45-50

Division of Neurosurgery, Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine and Surgery, Federico II University of Naples, Naples, Italy.

In recent years the use of the endoscope through the transclival route has gained new attention as a minimally invasive operative method to successfully treat numerous clival pathologies such as chordomas, meningiomas, haemangiopericytomas, enterogenous and epidermoid cysts, and metastasis(Cappabianca et al. Neurosurgery 55:933-940, 2004; Cappabianca et al. Childs Nerv Syst 20:796-801, 2004; Cappabianca et al. Read More

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http://dx.doi.org/10.1007/978-3-319-62515-7_7DOI Listing
January 2019

Successful Treatment of Lung Adenocarcinoma with Epidermal Growth Factor Receptor Compound Mutations Involving Exon 19 Deletion and Exon 20 Insertion by Afatinib.

Intern Med 2019 1;58(1):101-104. Epub 2019 Jan 1.

Department of Respiratory Medicine, Matsue Red Cross Hospital, Japan.

A 70-year-old woman was referred to our hospital after a nodular shadow was noted on chest X-ray. Chest computed tomography showed a pulmonary mass in the right upper lobe, and brain magnetic resonance imaging revealed a right-sided frontal lobe tumor. A histological examination of a transbronchial lung biopsy specimen revealed adenocarcinoma with epidermal growth factor receptor mutations involving both exon 19 deletion and exon 20 insertion. Read More

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http://dx.doi.org/10.2169/internalmedicine.0927-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367085PMC
January 2019
2 Reads

Non-Invasive Optical Guided Tumor Metastasis/Vessel Imaging by Using Lanthanide Nanoprobe with Enhanced Down-Shifting Emission Beyond 1500 nm.

ACS Nano 2019 Jan 3. Epub 2019 Jan 3.

Visualization of tumor vessels/metastasis and cerebrovascular architecture is vital important for analyzing pathological states of brain diseases and tumor's abnormal blood vessel to improve cancer diagnosis. In vivo fluorescence imaging using second near infrared emission beyond 1500 nm (NIR-IIb) is emerged as a next generation optical imaging method with significant improvement in imaging sensitivity and spatial resolution. Unfortunately, highly biocompatible probe capable of generating NIR-IIb emission with sufficient brightness and uniformed size is still scarce. Read More

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http://dx.doi.org/10.1021/acsnano.8b05431DOI Listing
January 2019

Predictive value of a nomogram for hepatocellular carcinoma with brain metastasis at initial diagnosis: A population-based study.

PLoS One 2019 2;14(1):e0209293. Epub 2019 Jan 2.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China.

Background: Population-based estimates of the incidence and prognosis of brain metastases at diagnosis of hepatocellular carcinoma (HCC) are lacking. The aim of this study was to characterize the incidence proportion and survival of newly diagnosed hepatocellular carcinoma with brain metastases (HCCBM).

Materials And Methods: Data from Surveillance, Epidemiology, and End Results (SEER) program between 2010 and 2014 was evaluated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314620PMC
January 2019
1 Read
3.234 Impact Factor

Multivoxel H-MR Spectroscopy Biometrics for Preoprerative Differentiation Between Brain Tumors.

Tomography 2018 Dec;4(4):172-181

Departments of Clinical Sciences/Division of Radiology.

We investigated multivoxel proton magnetic resonance spectroscopy (H-MRS) biometrics for preoperative differentiation and prognosis of patients with brain metastases (MET), low-grade glioma (LGG) and high-grade glioma (HGG). In total, 33 patients (HGG, 14; LGG, 9; and 10 MET) were included. H-MRS imaging (MRSI) data were assessed and neurochemical profiles for metabolites N-acetyl aspartate (NAA) + NAAG(NAA), Cr + PCr(total creatine, tCr), Glu + Gln(Glx), lactate (Lac), myo-inositol(Ins), GPC + PCho(total choline, tCho), and total lipids, and macromolecule (tMM) signals were estimated. Read More

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http://flipbook.tomography.org/publication/?i=551611&ver
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http://dx.doi.org/10.18383/j.tom.2018.00051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299741PMC
December 2018
7 Reads

Multiple brain metastases from pancreatic adenocarcinoma presenting with simultaneous intratumoral hemorrhages: A case report.

World Neurosurg 2018 Dec 19. Epub 2018 Dec 19.

Departments of Neurosurgery, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukuoka, Japan.

Background: Pancreatic adenocarcinoma rarely metastasizes to the brain, and the clinical features of brain metastasis in such cases remain elusive. To the best of our knowledge, only 21 cases of brain metastasis from pancreatic adenocarcinoma have been previously reported in the English-language literature.

Case Description: One year 4 months before the current admission, a 61-year-old woman was diagnosed with pancreatic adenocarcinoma and began chemotherapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183285
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http://dx.doi.org/10.1016/j.wneu.2018.12.036DOI Listing
December 2018
9 Reads

Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign".

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

We herein report the case of a 60-year-old man with a "target sign" in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis. F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. Read More

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http://dx.doi.org/10.2169/internalmedicine.1156-18DOI Listing
December 2018
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A proposal of imaging classification of intrahepatic mass-forming cholangiocarcinoma into ductal and parenchymal types: clinicopathologic significance.

Eur Radiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-Ro, Seodaemun-gu, Seoul, 03722, South Korea.

Objectives: To investigate the clinicopathologic significance of a subclassification of mass-forming intrahepatic cholangiocarcinoma (MF-iCCA) into ductal and parenchymal types based on magnetic resonance imaging (MRI) METHODS: We enrolled 72 consecutive patients, in whom MF-iCCA was diagnosed on preoperative MRI and surgical resection from January 2000 to March 2013. Two readers independently evaluated MRI findings of adjacent bile duct dilation, periductal tumor spread, and presence of diffuse dilatation or abnormality of the intrahepatic bile duct. MF-iCCAs with none of the aforementioned findings were defined as parenchymal type, and those with one or more findings were defined as ductal type. Read More

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http://dx.doi.org/10.1007/s00330-018-5898-9DOI Listing
December 2018
1 Read

Meningeal carcinomatosis presenting with leukoencephalopathy-like imaging findings.

eNeurologicalSci 2019 Mar 19;14:21-23. Epub 2018 Nov 19.

Department of Neurology, University of Tsukuba, 1-1-1 Tenodai, Tsukuba-city, Japan.

Meningeal carcinomatosis is a unique and rare form of metastasis observed in patients with malignant tumours. Diagnosis is simple when the primary lesion of the malignant tumour is clear, and when multiple miliary lesions are confirmed via cranial contrast MRI; however, many patients exhibit atypical imaging findings. In the present report, we discuss the case of a 72-year-old man who presented with subacute consciousness impairment and MRI findings suggestive of progressive, bilateral leukoencephalopathy-like lesions around the ventricles. Read More

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http://dx.doi.org/10.1016/j.ensci.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275227PMC
March 2019
1 Read

Radiotherapy for oligometastatic cancer: a survey among radiation oncologists of Lombardy (AIRO-Lombardy), Italy.

Radiol Med 2018 Dec 15. Epub 2018 Dec 15.

S. C. Radioterapia, ASST dei Sette Laghi-Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Aims: To evaluate the use of radiotherapy (RT) for oligometastatic cancer (OMC) among radiation oncologists in Lombardy, Italy.

Methods And Study Design: A survey with 12 items regarding data of 2016 was sent to all 34 Lombardy RT centers. The survey included six general items and six specific items regarding patient/disease/treatment characteristics. Read More

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http://dx.doi.org/10.1007/s11547-018-0972-6DOI Listing
December 2018
1 Read

Preoperative stereotactic radiosurgery before planned resection of brain metastases: updated analysis of efficacy and toxicity of a novel treatment paradigm.

J Neurosurg 2018 Dec 14:1-8. Epub 2018 Dec 14.

1Levine Cancer Institute, Atrium Health.

OBJECTIVEPreoperative stereotactic radiosurgery (SRS) is a feasible alternative to postoperative SRS and may lower the risk of radiation necrosis (RN) and leptomeningeal disease (LMD) recurrence. The study goal was to report the efficacy and toxicity of preoperative SRS in an expanded patient cohort with longer follow-up period relative to prior reports.METHODSThe records for patients with brain metastases treated with preoperative SRS and planned resection were reviewed. Read More

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http://dx.doi.org/10.3171/2018.7.JNS181293DOI Listing
December 2018
2 Reads

Perforation of small intestine secondary to metastatic lung adenocarcinoma: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13469

Department of Emergency Surgery, Union Hospital.

Rationale: About 50% of patients with a diagnosis of nonsmall cell lung carcinoma exhibit metastatic disease at the time of diagnosis. The preferential sites of extrapulmonary spread are the lymph nodes, liver, brain, adrenal glands, and bones; gastrointestinal tract perforation secondary to metastatic lung cancer is extremely rare.

Patient Concerns: A 60-year-old male nonsmoker patient presented with a 20-day history of facial, neck, and right upper limb edema. Read More

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http://dx.doi.org/10.1097/MD.0000000000013469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310494PMC
December 2018

Proceedings of the 2018 next-generation Gamma Knife research meeting.

J Neurosurg 2018 Dec;129(Suppl1):5-9

7Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada.

In order to determine what areas of research are a clinical priority, a small group of young Gamma Knife investigators was invited to attend a workshop discussion at the 19th International Leksell Gamma Knife Society Meeting. Two areas of interest and the need for future radiosurgical research involving multiple institutions were identified by the young investigators working group: 1) the development of additional imaging sequences to guide the understanding, treatment, and outcome tracking of diseases such as tremor, radiation necrosis, and AVM; and 2) trials to clarify the role of hypofractionation versus single-fraction radiosurgery in the treatment of large lesions such as brain metastases, postoperative cavities, and meningiomas. Read More

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http://dx.doi.org/10.3171/2018.7.GKS181206DOI Listing
December 2018

Phase Ib/II single-arm trial evaluating the combination of everolimus, lapatinib and capecitabine for the treatment of HER2-positive breast cancer with brain metastases (TRIO-US B-09).

Ther Adv Med Oncol 2018 9;10:1758835918807339. Epub 2018 Nov 9.

University of California, Los Angeles, Los Angeles, CA, USA.

Background: Improving outcomes for patients with human epidermal growth factor 2-positive (HER2+) central nervous system (CNS) metastases remains an unmet clinical need. This trial evaluated a novel combination of everolimus, lapatinib and capecitabine for this disease.

Methods: Patients with trastuzumab-pretreated, HER2+ breast cancer brain metastasis without prior therapy with a mammalian target of rapamycin (mTOR) inhibitor were eligible. Read More

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http://dx.doi.org/10.1177/1758835918807339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236634PMC
November 2018
3 Reads

Pituitary Metastasis in a Patient with Pulmonary Adenocarcinoma Presenting with a Disturbance of Consciousness.

Klin Onkol 2018 ;31(5):371-375

Background: Brain metastases are one of the main causes of morbidity and mortality of patients with oncological disease. In non-small cell lung carcinoma (NSCLC), the risk of CNS secondary development is 30-50%. An unusual diagnostic and therapeutic problem is the finding of suspicious pituitary lesions. Read More

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http://dx.doi.org/10.14735/amko2018371DOI Listing
January 2018

Species-dependent extracranial manifestations of a brain seeking breast cancer cell line.

PLoS One 2018 10;13(12):e0208340. Epub 2018 Dec 10.

Department of Radiology, Ghent University Hospital, Ghent, Belgium.

Purpose: Metastatic brain tumors pose a severe problem in the treatment of patients with breast carcinoma. Preclinical models have been shown to play an important role in unraveling the underlying mechanisms behind the metastatic process and evaluation of new therapeutic approaches. As the size of the rat brain allows improved in vivo imaging, we attempted to establish a rat model for breast cancer brain metastasis that allows follow-up by 7 tesla (7T) preclinical Magnetic Resonance Imaging (MRI). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208340PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287854PMC
December 2018

New insights into the impact of primary lung adenocarcinoma location on metastatic sites and sequence: A multicenter cohort study.

Lung Cancer 2018 Dec 5;126:139-148. Epub 2018 Nov 5.

National Korányi Institute of Pulmonology, Budapest, Hungary. Electronic address:

Introduction: The presence of organ metastases is a major factor for unfavorable prognosis in lung adenocarcinoma (LADC). However, the influence of primary tumor location on metastatic sites and sequence has not been extensively analyzed.

Methods: We performed a multicenter cohort study, evaluating clinicopathological data of 1126 Caucasian LADC patients, focusing on the distinct location of primary tumors and metastatic sites during disease progression. Read More

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http://dx.doi.org/10.1016/j.lungcan.2018.11.004DOI Listing
December 2018
1 Read

Diffusion Kurtosis Imaging Reflects Glial Fibrillary Acidic Protein (GFAP), Topo IIα, and O⁶-Methylguanine-DNA Methyltransferase (MGMT) Expression in Astrocytomas.

Med Sci Monit 2018 Dec 6;24:8822-8830. Epub 2018 Dec 6.

Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China (mainland).

BACKGROUND Astrocytomas are the most common primary brain neoplasms. Biological indicators of astrocytomas can reflect its biological characteristics. The aim of this study was to assess the expression of the pathological glial fibrillary acidic protein (GFAP) Topo IIα and O⁶-methylguanine-DNA methyltransferase (MGMT) in astrocytomas using magnetic resonance (MR) diffusion kurtosis imaging (DKI) to evaluate the biological characteristics of astrocytomas. Read More

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https://www.medscimonit.com/abstract/index/idArt/911631
Publisher Site
http://dx.doi.org/10.12659/MSM.911631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292149PMC
December 2018
9 Reads

Developmental venous anomaly in adult patients with diffuse glioma: A clinically relevant coexistence?

Neurology 2019 Jan 30;92(1):e55-e62. Epub 2018 Nov 30.

From the Departments of Neurosurgery (A.R., M.Z., E.D., G.Z.-B., J.P.), Neuroradiology (M.E., S. Porelli, C.O), and Neuropathology (A.T.-E., P.V.), Sainte-Anne Hospital; Paris Descartes University (A.R., M.E., S. Porelli, A.T.-E., M.Z., E.D., G.Z.-B., S. Puget, P.V., C.O., J.P.), Sorbonne Paris Cité; Inserm (A.R., M.E., M.Z., E.D., P.V., C.O., J.P.), U894, IMA-Brain, Centre Psychiatrie et Neurosciences; Departments of Neuro-oncology (M.S.) and Neurosurgery (L.C.), Pitié-Salpêtrière Hospital; and Department of Pediatric Neurosurgery (S. Puget), Necker Hospital, Paris, France.

Objective: To determine the prevalence of developmental venous anomaly in adult patients with diffuse glioma.

Methods: We performed a retrospective cohort study (2010-2016) of consecutive adult patients harboring a supratentorial diffuse glioma in 2 centers: Sainte-Anne Hospital (experimental and control sets) and Pitié-Salpêtrière Hospital (external validation set). We included 219 patients with diffuse glioma (experimental set), 252 patients with brain metastasis (control set), and 200 patients with diffuse glioma (validation set). Read More

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http://www.neurology.org/lookup/doi/10.1212/WNL.000000000000
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http://dx.doi.org/10.1212/WNL.0000000000006690DOI Listing
January 2019
12 Reads

Intraspinal Dissemination and Local Recurrence of an Intracranial Hemangiopericytoma: Case Report.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Background: Hemangiopericytomas (HPCs) are rare vascular tumors that resemble meningiomas on imaging and have a high rate of local recurrence and metastases. There remains a paucity of data to guide management decisions of intraspinal dissemination of HPC in the literature, and none specifically related to anaplastic HPCs.

Case Description: Case report of a 34-year-old female with locally and distantly recurrent anaplastic hemangiopericytoma (HPC) (WHO grade III). Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.173DOI Listing
November 2018
1 Read

Tumour-to-Tumour Metastasis Phenomenon: Metastatic Prostatic Adenocarcinoma within an Anaplastic Oligodendroglioma in the Brain of a Dog.

J Comp Pathol 2018 Nov 29;165:62-66. Epub 2018 Oct 29.

Department of Animal Medicine and Surgery, Veterinary Faculty, Cerdanyola del Vallès, Spain; Networking Research Centre on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain.

A 10-year-old entire male French bulldog was presented following clusters of generalized tonic-clonic epileptic seizures. Neurolocalization was consistent with a lesion in the left forebrain. Magnetic resonance imaging of the brain revealed a large, ill-defined, intra-axial, space-occupying lesion at the level of the left temporal and parietal lobes, causing marked compression of the adjacent parenchyma. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.009DOI Listing
November 2018
1 Read

Subacute Venous Infarct Mimicking Cerebral Metastasis in 18F-FDG PET/CT.

Clin Nucl Med 2019 Feb;44(2):e120-e122

From the Departments of Nuclear Medicine and.

A 68-year-old woman with colon carcinoma was referred to F-FDG PET/CT imaging for staging. In addition to primary tumor involvement, PET/CT demonstrated focal FDG uptake in the right temporal lobe suggestive of primary brain tumor or metastasis. To delineate the lesion, a brain MRI scan showed sigmoid sinus thrombosis and vasogenic edema in the right temporal lobe. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002391DOI Listing
February 2019
12 Reads

MRI Evaluation of the effects of Whole Brain Radiotherapy on Breast Cancer Brain Metastasis.

Int J Radiat Biol 2018 Nov 30:1-27. Epub 2018 Nov 30.

a Department of Biomedical Engineering , Wake Forest School of Medicine.

Purpose: To assess early changes in brain metastasis in response to whole brain radiotherapy (WBRT) by longitudinal Magnetic Resonance Imaging (MRI).

Materials And Methods: Using a 7T system, MRI examination of brain metastases in a breast cancer MDA-MD231-Br mouse model were conducted before and 24 hours after 3 daily fractionations of 4 Gy WBRT. Besides anatomic MRI, diffusion-weighted (DW) MRI and dynamic contrast enhanced (DCE) MRI were applied to study cytotoxic effect and blood-tumor-barrier (BTB) permeability change, respectively. Read More

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https://www.tandfonline.com/doi/full/10.1080/09553002.2019.1
Publisher Site
http://dx.doi.org/10.1080/09553002.2019.1554920DOI Listing
November 2018
13 Reads