61,338 results match your criteria Brain Metastasis Imaging


Risk Factors for Brain Metastases in Patients With Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.

Front Oncol 2022 10;12:889161. Epub 2022 Jun 10.

Department of Pulmonary Diseases, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center+, Maastricht, Netherlands.

The use of prophylactic cranial irradiation (PCI) for small cell lung cancer (SCLC) patients is controversial. Risk factors for brain metastasis (BM) development are largely lacking, hampering personalized treatment strategies. This study aimed to identify the possible risk factors for BM in SCLC. Read More

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Metastasis to the Bladder: A Rare Site of Recurrence of Renal Cell Carcinoma.

Case Rep Urol 2022 17;2022:4339270. Epub 2022 Jun 17.

The James Buchanan Brady Urologic Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Renal cell carcinoma (RCC) is considered to be the deadliest urologic cancer with high rates of metastasis and recurrence after nephrectomy. RCC can metastasize to nearly any organ but most commonly metastasizes to the liver, lung, brain, and bone. To date, there are only about 40 reported cases of RCC with solitary bladder metastasis. Read More

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Incidence and survival of patients with oligometastatic esophagogastric cancer: a multicenter cohort study.

Radiother Oncol 2022 Jun 23. Epub 2022 Jun 23.

Department of Radiation Oncology, University Hospital Zurich, University Zurich, Switzerland. Electronic address:

Purpose /objective: This multicenter study assessed the incidence and survival of patients with esophagogastric cancer and oligometastatic disease (OMD) in two tertiary referral cancer centers in The Netherlands and Switzerland.

Materials /methods: Between 2010-2021, patients with metastatic esophagogastric cancer were identified. Patients with de-novo OMD were included (first-time diagnosis of ≤5 distant metastases on F-FDG-PET/CT). Read More

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Neurofibromatosis from Head to Toe: What the Radiologist Needs to Know.

Radiographics 2022 Jun 24:210235. Epub 2022 Jun 24.

From the Department of Radiology (M.X.W., C.T.J., K.M.E.) and Department of Lymphoma and Myeloma (S.K.), University of Texas MD Anderson Cancer Center, Pickens Academic Tower, 1400 Pressler St, Houston, TX 77030-4009; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio (J.R.D.); Department of Radiology, Stanford University, Stanford, Calif (J.G.); Department of Radiology (A.H.) and Faculty of Medicine (M.M.), Alexandria University, Alexandria, Egypt; and Department of Radiology, Mayo Clinic Arizona, Phoenix/Scottsdale, Ariz (P.M.P.).

Neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2) are autosomal dominant inherited neurocutaneous disorders or phakomatoses secondary to mutations in the and tumor suppressor genes, respectively. Although they share a common name, NF1 and NF2 are distinct disorders with a wide range of multisystem manifestations that include benign and malignant tumors. Imaging plays an essential role in diagnosis, surveillance, and management of individuals with NF1 and NF2. Read More

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Pembrolizumab-induced aseptic meningitis in a patient with non-small cell lung cancer: A case report and literature review of aseptic meningitis as an immune-related adverse event.

Mol Clin Oncol 2022 Jul 1;17(1):120. Epub 2022 Jun 1.

Department of Multidisciplinary Internal Medicine, Division of Respiratory Medicine and Rheumatology, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan.

Aseptic meningitis is a rare immune-related adverse event (irAE), which occurs during treatment with immune checkpoint inhibitors (ICIs). This condition has non-specific symptoms and exhibits no clear signs on magnetic resonance imaging (MRI). There are only a few reports of aseptic meningitis caused by pembrolizumab treatment for non-small cell lung cancer (NSCLC). Read More

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The Value of FET PET/CT in Recurrent Glioma with a Different IDH Mutation Status: The Relationship between Imaging and Molecular Biomarkers.

Int J Mol Sci 2022 Jun 17;23(12). Epub 2022 Jun 17.

Experimental Particle Physics Department, Jožef Stefan Institute, 1000 Ljubljana, Slovenia.

The evaluation of treatment response remains a challenge in glioma cases because the neuro oncological therapy can lead to the development of treatment-related changes (TRC) that mimic true progression (TP). Positron emission tomography (PET) using O-(2-[F] fluoroethyl-)-L-tyrosine (F-FET) has been shown to be a useful tool for detecting TRC and TP. We assessed the diagnostic performance of different F-FET PET segmentation approaches and different imaging biomarkers for differentiation between late TRC and TP in glioma patients. Read More

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High Myoinositol on Proton MR Spectroscopy Could Be a Potential Signature of Papillary Tumors of the Pineal Region-Case Report of Two Patients.

Brain Sci 2022 Jun 19;12(6). Epub 2022 Jun 19.

Institut de Diagnóstic per la Imatge (IDI), Department of Radiology, Hospital de Bellvitge, 08908 L'Hospitalet de Llobregat, Barcelona, Spain.

Papillary tumor of the pineal region (PTPR) is an uncommon entity in which a presurgical suspicion may be crucial for patient management. Maximal safe neurosurgical resection is of choice when PTPR is suspected, whereas non-surgical approaches can be considered in other tumors of the pineal region, such as pineocytoma or concrete subtypes of germ-cell tumors. In general terms, imaging features of tumors of the pineal region have been reported to be unspecific. Read More

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Pineal region teratoma with metastases in uncommon locations: a case report.

J Med Case Rep 2022 Jun 23;16(1):261. Epub 2022 Jun 23.

Department of Neurology, Al Assad Damascus University Hospital, Damascus, Syria.

Background: We report a rare case in medical literature of a patient with pineal gland teratoma and uncommon metastases. Usually, metastases of this kind of tumor are located in several organs such as lung and breast, but here we found metastases to the spinal cord and vertebrae.

Case Presentation: A 35-year-old Asian white man presented with diplopia and acute neural symptoms in the lower limbs such as numbness, tingling, and paralysis. Read More

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Atypical Cognitive Impairment and Recovery in Two Colorectal Cancer Patients.

Tomography 2022 Jun 9;8(3):1503-1508. Epub 2022 Jun 9.

Department of Neurology, Jeonbuk National University Medical School and Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea.

Cognitive impairment in cancer patients can be caused by various factors; in approximately 30% of cancer patients, the symptoms appear before starting treatment. Paraneoplastic limbic encephalitis (PLE) is a rare disease associated with an autoimmune response, and is characterized by memory loss, depression, and personality changes; it is one of the potential causes of cognitive dysfunction in cancer patients. Two patients were previously diagnosed with mild cognitive impairment and maintained clinical stability; after suffering a rapid change in personality and sudden cognitive decline, colorectal cancer was diagnosed within a few months. Read More

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Temporal Horn Enlargements Predict Secondary Hydrocephalus Diagnosis Earlier than Evans' Index.

Tomography 2022 May 25;8(3):1429-1436. Epub 2022 May 25.

Academic Neurology Unit, Department of Medical-Surgical Sciences and Biotechnologies, Ospedale A. Fiorini, "Sapienza" University of Rome, 04019 Terracina, Italy.

The aim of this study was to identify early radiological signs of secondary hydrocephalus. We retrieved neuroradiological data from scans performed at various times in patients who underwent surgery for secondary hydrocephalus due to severe traumatic brain injury (TBI), subarachnoid haemorrhage (SAH), or brain tumour (BT). Baseline measurements, performed on the earliest images acquired after the neurological event (T0), included Evans' index, the distance between frontal horns, and the widths of both temporal horns. Read More

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Radiomic Signatures for Predicting Receptor Status in Breast Cancer Brain Metastases.

Front Oncol 2022 6;12:878388. Epub 2022 Jun 6.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.

Backgrounds: A significant proportion of breast cancer patients showed receptor discordance between primary cancers and breast cancer brain metastases (BCBM), which significantly affected therapeutic decision-making. But it was not always feasible to obtain BCBM tissues. The aim of the present study was to analyze the receptor status of primary breast cancer and matched brain metastases and establish radiomic signatures to predict the receptor status of BCBM. Read More

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Use of virtual magnetic resonance imaging to compensate for brain shift during image-guided surgery: illustrative case.

J Neurosurg Case Lessons 2022 Jun 13;3(24):CASE21683. Epub 2022 Jun 13.

Department of Neurosurgery, University of South Florida, Tampa, Florida; and.

Background: Maximal safe resection is the paramount objective in the surgical management of malignant brain tumors. It is facilitated through use of image-guided neuronavigation. Intraoperative image guidance systems use preoperative magnetic resonance imaging (MRI) as the navigational map. Read More

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Ellipsoid calculations versus manual tumor delineations for glioblastoma tumor volume evaluation.

Sci Rep 2022 Jun 22;12(1):10502. Epub 2022 Jun 22.

Department of Radiotherapy, ICANS, Institut Cancérologie Strasbourg Europe, 17 Rue Albert Calmette, 67200, Strasbourg Cedex, France.

In glioblastoma, the response to treatment assessment is essentially based on the 2D tumor size evolution but remains disputable. Volumetric approaches were evaluated for a more accurate estimation of tumor size. This study included 57 patients and compared two volume measurement methods to determine the size of different glioblastoma regions of interest: the contrast-enhancing area, the necrotic area, the gross target volume and the volume of the edema area. Read More

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Differentiation of hemangioblastoma from brain metastasis using MR amide proton transfer imaging.

J Neuroimaging 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background And Purpose: Differentiation between hemangioblastoma and brain metastasis remains a challenge in neuroradiology using conventional MRI. Amide proton transfer (APT) imaging can provide unique molecular information. This study aimed to evaluate the usefulness of APT imaging in differentiating hemangioblastomas from brain metastases and compare APT imaging with diffusion-weighted imaging and dynamic susceptibility contrast perfusion-weighted imaging. Read More

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Letter to the Editor: Depression As The First Symptom Of Frontal Lobe Grade 2 Malignant Glioma.

Turk Psikiyatri Derg 2022 ;33(2):143-145

Dear Editor, Next to focal neurological symptoms, epileptic seizures and head aches, brain tumors can less frequently bring about cognitive changes, slowed speech, difficulty sustaining mental functioning and psychiatric symptoms of personality changes and. loss of interest in daily activities, these symptoms may be evaluated as anxiety or depression. Depression is known to be a complication of brain tumours and may sometimes be seen after the presentation of neurological symptoms linked to brain tumours, and sometimes after tumor treatment (Oğuz et al. Read More

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Predicting the outcome of radiotherapy in brain metastasis by integrating the clinical and MRI-based deep learning features.

Med Phys 2022 Jun 21. Epub 2022 Jun 21.

Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON, Canada.

Background: A considerable proportion of metastatic brain tumours progress locally despite stereotactic radiation treatment, and it can take months before such local progression is evident on follow-up imaging. Prediction of radiotherapy outcome in terms of tumour local failure is crucial for these patients and can facilitate treatment adjustments or allow for early salvage therapies.

Purpose: In this work, a novel deep learning architecture is introduced to predict the outcome of local control/failure in brain metastasis treated with stereotactic radiation therapy (SRT) using treatment-planning MRI and standard clinical attributes. Read More

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Endoscopic Transpterygoid Transcavernous Approach for Resection of a Petroclival Chondrosarcoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e60-e61. Epub 2022 Apr 20.

Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, USA.

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Subtemporal Transcollateral Sulcus Approach for Temporal Horn Tumors: 2-Dimensional Operative Video and Description of the Technique.

Oper Neurosurg (Hagerstown) 2022 Jul 20;23(1):e10-e15. Epub 2022 Apr 20.

Department of Neurosurgery, The University of Arizona College of Medicine, Phoenix, Arizona, USA.

Introduction: Purely temporal intraventricular tumors are uncommon. Given their deep location, access to these brain tumors can be challenging in terms of preserving brain tissue. The subtemporal approach spares the lateral temporal cortex and is a less traumatic corridor to reach intraventricular temporal tumors. Read More

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A rare central nervous system tumor of childhood with spongiform appearance on brain magnetic resonance imaging; primary diffuse leptomeningeal oligodendrogliomatosis.

Neurocirugia (Astur : Engl Ed) 2022 Jul-Aug;33(4):190-194

Ege University, Faculty of Medicine, Department of Neurosurgery, İzmir, Turkey.

Primary diffuse leptomeningeal oligodendrogliomatosis is a rare fatal tumor of childhood. Symptoms usually occur when the tumor causes hydrocephalus. Brain magnetic resonance imaging (MRI) may be nearly normal in the early stages of the disease, while hydrocephalus and multiple leptomeningeal cysts with spongiform appearance may appear later on. Read More

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Case Report: Acquired Generalized Anhidrosis Caused by Brain Tumor: Review of the Literature.

Front Endocrinol (Lausanne) 2022 26;13:877715. Epub 2022 May 26.

Department of Pediatrics, Aichi Medical University School of Medicine, Nagakute, Japan.

Purpose: There has been limited focus on sweating failure in patients with brain tumor. We report two patients with generalized anhidrosis caused by germinoma. We also review previous reports of generalized anhidrosis due to brain tumor. Read More

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Facts and Fictions About [F]FDG versus Other Tracers in Managing Patients with Brain Tumors: It Is Time to Rectify the Ongoing Misconceptions.

PET Clin 2022 Jul;17(3):327-342

Division of Nuclear Medicine and Oncological Imaging, Department of Medical Physics, CHU of Liege, Quartier Hopital, Avenue de l'hopital, 1, Liege 1 4000, Belgium; GIGA-CRC in vivo imaging, University of Liege, GIGA CHU - B34 Quartier Hôpital Avenue de l'Hôpital,11, 4000 Liège, Belgium.

MRI is the first-choice imaging technique for brain tumors. Positron emission tomography can be combined together with multiparametric MRI to increase diagnostic confidence. Radiolabeled amino acids have gained wide clinical acceptance. Read More

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Reliability of dynamic susceptibility contrast perfusion metrics in pre- and post-treatment glioma.

Cancer Imaging 2022 Jun 17;22(1):28. Epub 2022 Jun 17.

Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 EZ, Nijmegen, The Netherlands.

Background: In neuro-oncology, dynamic susceptibility contrast magnetic resonance (DSC-MR) perfusion imaging emerged as a tool to aid in the diagnostic work-up and to surveil effectiveness of treatment. However, it is believed that a significant variability exists with regard to the measured in DSC-MR perfusion parameters. The aim of this study was to assess the observer variability in measured DSC-MR perfusion parameters in patients before and after treatment. Read More

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Diffuse midline glioma with H3-K27M mutation: A rare case with GFAP-positive anucleate whorled patterns.

Medicine (Baltimore) 2022 Jun 17;101(24):e29448. Epub 2022 Jun 17.

Department of Pathology, The First Affiliated Hospital of China Medical University, Shenyang, P.R. China.

Introduction: Diffuse midline glioma with H3-K27M mutation is an infiltrative high-grade glioma, with predominantly astrocytic differentiation.

Patient Concerns: A 54-year-old Chinese woman presented with memory loss for a month and walking instability for 15 days.

Diagnosis: Magnetic resonance imaging showed a mass shadow of isometric T1 and slightly longer T2 with mild mixed signals in the third ventricle of the suprasellar region. Read More

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Validity of magnetic resonance imaging (MRI) in the primary spinal cord tumors in routine clinical setting.

Sci Rep 2022 Jun 16;12(1):10151. Epub 2022 Jun 16.

Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.

MRI is the primary diagnostic modality for spinal cord tumors. However, its validity has never been vigorously scrutinized in daily routine clinical practice, where MRI tissue diagnosis is usually not a single one but multiple ones with several differential diagnoses. Here, we aimed to assess the validity of MRI in terms of predicting the pathology and location of the tumor in routine clinical settings. Read More

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Recent development of contrast agents for magnetic resonance and multimodal imaging of glioblastoma.

J Nanobiotechnology 2022 Jun 16;20(1):284. Epub 2022 Jun 16.

School of Science and Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Harbin Institute of Technology, Shenzhen, 518055, China.

Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high incidence and degree of malignancy as well as poor prognosis. Due to the existence of formidable blood-brain barrier (BBB) and the aggressive growth and infiltrating nature of GBM, timely diagnosis and treatment of GBM is still very challenging. Among different imaging modalities, magnetic resonance imaging (MRI) with merits including high soft tissue resolution, non-invasiveness and non-limited penetration depth has become the preferred tool for GBM diagnosis. Read More

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The 2021 World Health Organization Classification of Tumors of the Central Nervous System: What Neuroradiologists Need to Know.

AJNR Am J Neuroradiol 2022 Jun 16. Epub 2022 Jun 16.

From the Department of Radiology and Imaging Sciences (A.G.O., K.L.S.), University of Utah School of Medicine, Salt Lake City, Utah

Neuroradiologists play a key role in brain tumor diagnosis and management. Staying current with the latest classification systems and diagnostic markers is important to provide optimal patient care. Publication of the 2016 World Health Organization Classification of Tumors of the Central Nervous System introduced a paradigm shift in the diagnosis of CNS neoplasms. Read More

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Local recurrence of uveal melanoma and concomitant brain metastases associated with an activating telomerase promoter mutation seven years after secondary enucleation.

Am J Ophthalmol Case Rep 2022 Sep 1;27:101607. Epub 2022 Jun 1.

Department of Ophthalmology and Visual Science, Yale School of Medicine, 40 Temple Street Suite 3D, New Haven, CT, 06510, USA.

Purpose: To describe a case of local recurrence of uveal melanoma with concomitant brain metastases after secondary enucleation.

Observations: A 73 year-old patient presented with dizziness and gait instability. MRI of the orbits and brain showed an anophthalmic socket with an orbital implant and an associated optic nerve mass as well as multiple mass lesions in the brain. Read More

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September 2022

Progression Patterns in Non-Contrast-Enhancing Gliomas Support Brain Tumor Responsiveness to Surgical Lesions.

Pathol Oncol Res 2022 30;28:1610268. Epub 2022 May 30.

Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.

The overall benefit of surgical treatments for patients with glioma is undisputed. We have shown preclinically that brain tumor cells form a network that is capable of detecting damage to the tumor, and repair itself. The aim of this study was to determine whether a similar mechanism might contribute to local recurrence in the clinical setting. Read More

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Development of a robust radiomic biomarker of progression-free survival in advanced non-small cell lung cancer patients treated with first-line immunotherapy.

Sci Rep 2022 Jun 15;12(1):9993. Epub 2022 Jun 15.

Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.

We aim to determine the feasibility of a novel radiomic biomarker that can integrate with other established clinical prognostic factors to predict progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC) undergoing first-line immunotherapy. Our study includes 107 patients with stage 4 NSCLC treated with pembrolizumab-based therapy (monotherapy: 30%, combination chemotherapy: 70%). The ITK-SNAP software was used for 3D tumor volume segmentation from pre-therapy CT scans. Read More

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A Case of Pituitary Macroadenoma Presenting as Aseptic Meningitis.

S D Med 2022 Feb;75(2):88-90

University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Pituitary adenomas are a common brain tumor that are frequently asymptomatic but may initially present with vision deficits or very rarely as meningitis thought to be due to cerebrospinal fluid leakage. In this case report we discuss the initial presentation of a pituitary macroadenoma as aseptic meningitis, particularly in the absence of an identifiable cerebrospinal fluid leak. We also discuss the workup and diagnostic challenges associated with this atypical presentation, including findings on imaging and pertinent laboratory results. Read More

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February 2022