5,043 results match your criteria Brain Metastasis Imaging


Natural Language Processing for Automated Quantification of Brain Metastases Reported in Free-Text Radiology Reports.

JCO Clin Cancer Inform 2019 Apr(3):1-9

1 Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Purpose: Although the bulk of patient-generated health data are increasing exponentially, their use is impeded because most data come in unstructured format, namely as free-text clinical reports. A variety of natural language processing (NLP) methods have emerged to automate the processing of free text ranging from statistical to deep learning-based models; however, the optimal approach for medical text analysis remains to be determined. The aim of this study was to provide a head-to-head comparison of novel NLP techniques and inform future studies about their utility for automated medical text analysis. Read More

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http://dx.doi.org/10.1200/CCI.18.00138DOI Listing

Brain Metastasis in Papillary Serous Adenocarcinoma of the Endometrium.

Rev Bras Ginecol Obstet 2019 Apr 16. Epub 2019 Apr 16.

Department of Specialized Medicine, Universidade Federal do Piauí, Teresina, PI, Brazil.

Background:  Most endometrial cancers (75%) are diagnosed in early stages (stages I and II), in which abnormal uterine bleeding is the most frequent clinical sign. When the diagnosis is performed in stage IV, the most common sites of metastasis are the lungs, liver and bones. Central nervous system (CNS) metastasis is a rare condition. Read More

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http://dx.doi.org/10.1055/s-0039-1683353DOI Listing
April 2019
4 Reads

A vascular-task response dependency and its application in functional imaging of brain tumors.

J Neurosci Methods 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA; Functional MRI Laboratory, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Neuroscience, Weill-Cornell Graduate School of the Medical Sciences, New York, NY, USA.

Purpose: Preoperative functional MRI (fMRI) is limited by a muted BOLD response caused by abnormal vasoreactivity and resultant neurovascular uncoupling adjacent to malignant brain tumors. We propose to overcome this limitation and more accurately identify eloquent areas adjacent to brain tumors by independently assessing vasoreactivity using breath-holding and incorporating these data into the fMRI analysis.

Methods: Local vasoreactivity using a breath-holding paradigm with the same timing as the functional motor and language tasks was determined in 16 patients (9 glioblastomas, 1 anaplastic astrocytoma, 5 low grade astrocytomas, and 1 metastasis) and 6 healthy control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650270193011
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http://dx.doi.org/10.1016/j.jneumeth.2019.04.004DOI Listing
April 2019
3 Reads

Vascular white matter lesions negatively correlate with brain metastases in malignant melanoma-Results from a retrospective comparative analysis.

Clin Neurol Neurosurg 2019 May 19;180:117-121. Epub 2019 Mar 19.

Klinik für Radioonkologie und Strahlentherapie, Universitätsklinikum Leipzig, Stephanstraße 9 a, 04103, Leipzig, Germany. Electronic address:

Objectives: Brain metastasis (BM) is a major complication of different cancers. There is increasing evidence for influence of vascular factors on BM in patients with non-small cell lung cancer (NSCLC). It is not known if the same is true for other tumors that might rely on different forms of vasculogenesis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.03.016DOI Listing
May 2019
1 Read

Metastatic Cutaneous Melanoma Presenting with Choroidal Metastasis Simulating Primary Uveal Melanoma.

Ocul Oncol Pathol 2019 Feb 8;5(2):135-138. Epub 2018 Aug 8.

Department of Ophthalmology, University of California, San Francisco, California, USA.

Purpose: To report a case of metastatic cutaneous melanoma presenting with choroidal metastasis simulating primary uveal melanoma.

Design: Case report.

Method: Presentation of clinical, radiographic, histopathologic, and tumor genetic findings in a patient with cutaneous melanoma with choroidal metastasis. Read More

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https://www.karger.com/Article/FullText/488708
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http://dx.doi.org/10.1159/000488708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422132PMC
February 2019
4 Reads

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis.

Acta Neuropathol Commun 2019 Apr 10;7(1):55. Epub 2019 Apr 10.

Kristian Gerhard Jebsen Brain Tumour Research Centre, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway.

Melanoma patients carry a high risk of developing brain metastases, and improvements in survival are still measured in weeks or months. Durable disease control within the brain is impeded by poor drug penetration across the blood-brain barrier, as well as intrinsic and acquired drug resistance. Augmented mitochondrial respiration is a key resistance mechanism in BRAF-mutant melanomas but, as we show in this study, this dependence on mitochondrial respiration may also be exploited therapeutically. Read More

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http://dx.doi.org/10.1186/s40478-019-0712-8DOI Listing
April 2019
5 Reads

Low grade intracranial meningioma presenting with pulmonary metastasis: Case report and literature review.

Pathol Res Pract 2019 Mar 19. Epub 2019 Mar 19.

Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, 96813, United States; Department of Pathology, Queen's Medical Center, Honolulu, HI, 96813, United States. Electronic address:

Meningioma is a common neoplasm in the central nervous system. Even though most meningiomas tend to have a benign, indolent clinical course, metastasis can occur. We describe a case of a 59-year-old woman who presented with an incidental finding of multiple lung masses. Read More

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http://dx.doi.org/10.1016/j.prp.2019.03.018DOI Listing
March 2019
1 Read

Do renal cell carcinoma patients with brain metastases still need nephrectomy?

Int Urol Nephrol 2019 Apr 5. Epub 2019 Apr 5.

Department of Urology, The Second Affiliated Hospital of Fujian Medical University, Licheng District Zhongshan North Road, Quanzhou, 362000, Fujian, China.

Purpose: To evaluate the value of nephrectomy for survival prognosis in renal cell carcinoma (RCC) patients with brain metastases (BM).

Methods: There were 933 RCC patients diagnosed with BM in SEER database from 2010 to 2014. Kaplan-Meier method and Cox regression model were used to analyze the survival prognosis. Read More

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http://dx.doi.org/10.1007/s11255-019-02139-9DOI Listing
April 2019
2 Reads

Solitary cerebellum metastasis from gastric adenocarcinoma. A rare case report.

Int J Surg Case Rep 2019 Mar 18;57:110-112. Epub 2019 Mar 18.

University of Athens, Department of Anatomy and Surgical Anatomy, Medical School, National and Kapodestrian University of Athens, Greece.

Introduction: The present study reports a case of signet-ring gastric adenocarcinoma with isolated cerebellum metastasis 2 years after gastrectomy.

Presentation Of A Case: Brain metastases originating from gastric cancer are rare accounting for 2.1-3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612193011
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http://dx.doi.org/10.1016/j.ijscr.2019.02.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446051PMC
March 2019
1 Read

Application of MR morphologic, diffusion tensor, and perfusion imaging in the classification of brain tumors using machine learning scheme.

Neuroradiology 2019 Apr 4. Epub 2019 Apr 4.

Department of Diagnostic Imaging, Sheba Medical Center, Ramat-Gan, Israel, 2 Sheba Rd, 52621, Ramat Gan, Israel.

Purpose: While MRI is the modality of choice for the assessment of patients with brain tumors, differentiation between various tumors based on their imaging characteristics might be challenging due to overlapping imaging features. The purpose of this study was to apply a machine learning scheme using basic and advanced MR sequences for distinguishing different types of brain tumors.

Methods: The study cohort included 141 patients (41 glioblastoma, 38 metastasis, 50 meningioma, and 12 primary central nervous system lymphoma). Read More

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http://dx.doi.org/10.1007/s00234-019-02195-zDOI Listing
April 2019
2 Reads

The Role of F-FDG PET/CT in Detecting Ovarian Cancer Recurrence in Patients with Elevated CA-125 Levels

Mol Imaging Radionucl Ther 2019 Mar;28(1):8-14

Aydın Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey

Objectives: To investigate the role of F-FDG positron emission tomography/computed tomography (PET/CT) in detection of recurrence in ovarian cancer patients with increased CA-125 levels.

Methods: Fifty-two patients (30-80 years old, mean: 58.5±10. Read More

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http://dx.doi.org/10.4274/mirt.galenos.2018.00710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455098PMC
March 2019
2 Reads

Clinicopathological Characteristics of Meningiomas: Experience from a Tertiary Care Hospital in the Kashmir Valley.

Asian J Neurosurg 2019 Jan-Mar;14(1):41-46

Department of Neurosurgery, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.

Background: Meningiomas comprise 15%-20% of all primary intracranial tumors. They are generally benign tumors, and most patients are cured after surgery and remain free of recurrence. However, some tumors behave in an aggressive manner, and patients develop local recurrence or metastasis. Read More

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http://www.asianjns.org/text.asp?2019/14/1/41/252596
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http://dx.doi.org/10.4103/ajns.AJNS_228_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417349PMC
April 2019
3 Reads

Differentiating glioblastomas from solitary brain metastasis using arterial spin labeling perfusion and diffusion tensor imaging derived metrics.

World Neurosurg 2019 Mar 27. Epub 2019 Mar 27.

Aim Of Work: to differentiate glioblastomas from solitary brain metastasis using arterial spin labeling perfusion (ASL) and diffusion tensor imaging (DTI) derived metrics.

Patients And Methods: Prospective study was done on 36 patients with provisional diagnosis of glioblastomas versus brain metastasis that underwent ASL and DTI of the brain. The tumor blood flow (TBF), and DTI metrics (FA and MD) of the enhancing tumoral and peritumoral parts were measured. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.213DOI Listing
March 2019
3 Reads

Distribution and Activity of Lenvatinib in Brain Tumor Models of Human Anaplastic Thyroid Cancer Cells in Severe Combined Immune Deficient Mice.

Mol Cancer Ther 2019 Mar 29. Epub 2019 Mar 29.

Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

Anaplastic thyroid carcinoma (ATC) is a rare but aggressive undifferentiated tumor that frequently metastasizes to the brain. The multiple kinase inhibitor lenvatinib and sorafenib have been approved to treat unresectable differentiated thyroid cancer, and lenvatinib has been approved in Japan to treat ATC. This study compared the effects of lenvatinib and sorafenib in mouse models of central nervous system metastases of ATC. Read More

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http://dx.doi.org/10.1158/1535-7163.MCT-18-0695DOI Listing
March 2019
4 Reads

Signal intensity increases in dentate nucleus/globus pallidus/pulvinar on unenhanced T1WI MR images after multiple examinations with gadodiamide.

Neuroradiol J 2019 Mar 29:1971400919839646. Epub 2019 Mar 29.

1 Katsuta Hospital Mito GammaHouse, Hitachinaka, Japan.

Background And Purpose: Elevated signal intensity (SI) in the dentate nucleus (DN), globus pallidus (GP) and pulvinar (PUL) was reportedly observed on unenhanced T1-weighted (T1WI) magnetic resonance (MR) images in patients receiving multiple enhanced MR examinations. We aimed to clarify whether this phenomenon influences the long-term neurological status of patients.

Materials And Methods: We studied 196 radiosurgically treated patients undergoing ≥10 MR examinations using a single dose of gadodiamide and the same 1. Read More

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http://journals.sagepub.com/doi/10.1177/1971400919839646
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http://dx.doi.org/10.1177/1971400919839646DOI Listing
March 2019
3 Reads

Prophylactic TLR9 stimulation reduces brain metastasis through microglia activation.

PLoS Biol 2019 Mar 28;17(3):e2006859. Epub 2019 Mar 28.

Neurobiology Department, Tel Aviv University, Tel Aviv, Israel.

Brain metastases are prevalent in various types of cancer and are often terminal, given the low efficacy of available therapies. Therefore, preventing them is of utmost clinical relevance, and prophylactic treatments are perhaps the most efficient strategy. Here, we show that systemic prophylactic administration of a toll-like receptor (TLR) 9 agonist, CpG-C, is effective against brain metastases. Read More

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http://dx.doi.org/10.1371/journal.pbio.2006859DOI Listing
March 2019
1 Read

[A Case of Breast Cancer with Parenchymal and Meningeal Central Nervous System Metastases Treated with Multimodality Therapy].

Gan To Kagaku Ryoho 2019 Mar;46(3):463-465

Dept. of Breast Surgery, Saiseikai Kyoto Hospital.

A 64-year-old woman who received neo-adjuvant chemotherapy and human epidermal growth factor receptor 2(HER2)- targeted therapy underwent modified radical mastectomy and axillary lymph node resection for HER2-positiveright breast cancer. After the surgery, chemotherapy, post-mastectomy radiation therapy, and HER2-targeted therapy were administered as adjuvant therapies. Two years and 6 months postoperatively, she complained of headaches and nausea. Read More

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March 2019
1 Read

Testicular mixed germ cell tumor presenting with seizure as the initial symptom: a case report and literature review.

Int Braz J Urol 2019 Mar 22;45. Epub 2019 Mar 22.

Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei City, Taiwan.

Most patients with testicular germ cell tumor present with a painless scrotal mass. We report a 19-year-old patient who presented with neurological complains. Rapid clinical progression to coma was noted during the staging work up. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0523DOI Listing
March 2019
1 Read

The Utility of Whole Body Imaging in the Evaluation of Solitary Brain Tumors.

World Neurosurg 2019 Mar 15. Epub 2019 Mar 15.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Electronic address:

Background: Solitary brain tumors can propose a diagnostic dilemma owing to the difficulty in differentiating between primary brain tumors and metastatic disease. The similar radiologic appearance on routine magnetic resonance imaging will necessitate the need for additional noninvasive testing. We sought to determine the clinical utility of preoperative whole body screening with computed tomography (CT) to detect metastatic disease in patients with solitary brain tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.228DOI Listing
March 2019
4 Reads

Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors.

Cancer Imaging 2019 Mar 18;19(1):14. Epub 2019 Mar 18.

UCLA Brain Tumor Imaging Laboratory (BTIL), Center for Computer Vision and Imaging Biomarkers, University of California, Los Angeles, Los Angeles, CA, USA.

Purpose: To identify clinically relevant magnetic resonance imaging (MRI) features of different types of metastatic brain lesions, including standard anatomical, diffusion weighted imaging (DWI) and dynamic susceptibility contrast (DSC) perfusion MRI.

Methods: MRI imaging was retrospectively assessed on one hundred and fourteen (N = 114) brain metastases including breast (n = 27), non-small cell lung cancer (NSCLC, n = 43) and 'other' primary tumors (n = 44). Based on 114 patient's MRI scans, a total of 346 individual contrast enhancing tumors were manually segmented. Read More

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http://dx.doi.org/10.1186/s40644-019-0201-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423873PMC
March 2019
1 Read

Brain metastasis from nasopharyngeal carcinoma treated with stereotactic radiosurgery.

World Neurosurg 2019 Mar 12. Epub 2019 Mar 12.

Department of Neurosurgery, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, and is associated with high recurrence and low survival rates; however, distant brain metastasis from NPC is rare. The authors report 3 cases of brain metastasis from NPC treated with stereotactic radiosurgery (SRS). A 49-year-old woman presented was diagnosed with brain metastasis from NPC, which occurred 53 months after initial diagnosis of NPC. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.029DOI Listing
March 2019
7 Reads

Rapidly progressive miliary brain metastasis of lung cancer after EGFR tyrosine kinase inhibitor discontinuation: An autopsy report.

Neuropathology 2019 Apr 13;39(2):147-155. Epub 2019 Mar 13.

Department of Pathology, Mitsui Memorial Hospital, Tokyo, Japan.

Miliary brain metastasis is a rare type of brain metastasis, in which carcinoma cells disseminate to numerous foci confined to Virchow-Robin/subpial spaces. Symptoms usually progress within several months, and magnetic resonance imaging (MRI) shows multiple small contrast-enhancing lesions. We report an autopsy case of a patient who rapidly deteriorated within a week due to miliary brain metastasis after epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) discontinuation, without contrast-enhancing lesions on MRI. Read More

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http://dx.doi.org/10.1111/neup.12542DOI Listing
April 2019
2 Reads

Bilateral Internal Auditory Canal Metastasis of Colon Carcinoma Mimicking Neurofibromatosis Type II: A Case Report and Literature Review.

World Neurosurg 2019 Mar 9. Epub 2019 Mar 9.

Department of Neurosurgery, The First Hospital of Jilin University, Changchun, Jilin, 130021, P.R. China. Electronic address:

Background: The vast majority of cerebellopontine angle tumors are benign with a favorable prognosis. Metastatic tumors occurring in the cerebellopontine angle are extremely rare. Herein, we report a case of colon carcinoma metastasis to the bilateral internal auditory canals. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.166DOI Listing
March 2019
1 Read

Role of Whole-Body F-FDG PET/CT in Screening for Metastases in Newly Diagnosed Sinonasal Malignancies.

AJR Am J Roentgenol 2019 Mar 12:1-8. Epub 2019 Mar 12.

1 Department of Radiology, University of Minnesota Medical Center, Fairview, 420 Delaware St SE, B-226 Mayo Memorial Bldg, MMC 292, Minneapolis, MN 55455.

Objective: The aim of this study is to assess the utility of pretreatment whole-body F-FDG PET/CT in screening for distant metastasis (DM) and regional lymphatic metastasis (LM).

Materials And Methods: Eighty-nine consecutive patients with untreated sinonasal malignant lesions (32 women and 57 men; mean age, 62 years) underwent whole-body FDG PET/CT between January 2009 and August 2017. A retrospective analysis was performed to determine the presence of DM and LM. Read More

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http://dx.doi.org/10.2214/AJR.18.20311DOI Listing
March 2019
2 Reads

Granulomatous CNS inflammation associated with seminoma.

J Neurol 2019 Mar 11. Epub 2019 Mar 11.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK.

Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment. Read More

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http://dx.doi.org/10.1007/s00415-019-09270-8DOI Listing
March 2019
1 Read

Loss of Neogenin1 in human colorectal carcinoma cells causes a partial EMT and wound-healing response.

Sci Rep 2019 Mar 11;9(1):4110. Epub 2019 Mar 11.

School of Biosciences, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

Neogenin1 (NEO1) is a receptor of the Deleted in Colorectal Carcinoma (DCC)/Frazzled/UNC-40 family, which regulates axon guidance but can also stabilize epithelial adherens junctions. NEO1 and DCC are also tumor suppressors that can inhibit metastasis by acting as dependence receptors. Given the role of NEO1 in maintaining adherens junctions we tested whether loss of NEO1 also promoted metastasis via an epithelial mesenchymal transition (EMT). Read More

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http://dx.doi.org/10.1038/s41598-019-40886-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411945PMC
March 2019
1 Read

Newly Diagnosed Metastatic Intracranial Ependymoma in Children: Frequency, Molecular Characteristics, Treatment, and Outcome in the Prospective HIT Series.

Oncologist 2019 Mar 8. Epub 2019 Mar 8.

Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Background: Data on frequency, clinical presentation, and outcome of primary metastatic intracranial ependymoma in children are scarce.

Patients And Methods: Prospective data on patients younger than 21 years with metastatic intracranial ependymoma at first diagnosis, registered from 2001 to 2014 in the HIT-2000 trial and the HIT-2000 Interim Registry, were analyzed.

Results: Of 453 registered patients with intracranial ependymoma and central neuropathology review, initial staging included spinal magnetic resonance imaging in all patients and lumbar cerebrospinal fluid (CSF) analysis in 402 patients. Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2018-0489DOI Listing
March 2019
13 Reads

Potential Impact of the Interval Between Imaging and Whole-brain Radiotherapy in Patients With Relatively Favorable Survival Prognoses.

Anticancer Res 2019 Mar;39(3):1343-1346

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany

Background/aim: The interval between diagnostic imaging and whole-brain radiotherapy (WBRT) had no significant impact on survival in our previous study of WBRT for brain metastases. Since median survival time was only 2 months, a potentially negative impact by delaying treatment could have been missed. Therefore, we performed an additional analysis of patients surviving at least 4 months following irradiation. Read More

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http://dx.doi.org/10.21873/anticanres.13247DOI Listing
March 2019
1 Read

A 3D quantitative imaging biomarker in pre-treatment MRI predicts overall survival after stereotactic radiation therapy of patients with a singular brain metastasis.

Acta Radiol 2019 Mar 6:284185119831692. Epub 2019 Mar 6.

4 Department of Radiation Oncology, Charité - University Medicine, Berlin, Germany.

Background: Brain metastases (BM) are the most frequent intracranial malignant tumor. Various prognostic factors facilitate the prediction of survival; however, few have become tools for clinical use.

Purpose: To investigate the role of three-dimensional (3D) quantitative tissue enhancement in pre-treatment cranial magnetic resonance imaging (MRI) as a radiomic biomarker for survival (OS) in patients with singular BM treated with stereotactic radiation therapy (SRT). Read More

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http://dx.doi.org/10.1177/0284185119831692DOI Listing
March 2019
1 Read

Focal radiation therapy for limited brain metastases is associated with high rates of local control and low subsequent whole brain radiation therapy.

ANZ J Surg 2019 Apr 5;89(4):418-422. Epub 2019 Mar 5.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Background: Assess clinical outcomes of focal radiotherapy (RT) in patients with limited brain metastasis (LBM) with whole brain RT (WBRT) avoidance.

Methods: Patients diagnosed with LBM were entered into a database between January 2010 and February 2017. Patients were recommended WBRT avoidance with focal therapy and three-monthly magnetic resonance imaging. Read More

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http://dx.doi.org/10.1111/ans.15040DOI Listing
April 2019
5 Reads

Lung Adenocarcinoma Metastasis to the Prostate: A Case Report.

Pract Radiat Oncol 2019 03;9(2):77-80

Department of Radiation Oncology, CHUV, Lausanne, Switzerland.

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http://dx.doi.org/10.1016/j.prro.2018.11.010DOI Listing

68Ga-DOTATOC PET/CT Differentiates Meningioma From Dural Metastases.

Clin Nucl Med 2019 May;44(5):412-413

Radiation Oncology, and.

A 77-year-old woman with history of breast cancer presented with 2 unclear dural contrast-enhancing lesions on MRI; differential diagnoses were breast cancer metastases and meningiomas. On Ga-DOTATOC PET/CT, the temporal lesion showed high uptake and was classified as meningioma, whereas the lesion at the falx showed barely any Ga-DOTATOC uptake uncharacteristic for meningioma and suggestive for a brain metastasis. After resection, histological specimens from the temporal lesion showed meningioma tissue with distinct SSTR2A expression, whereas the falx lesion revealed a breast cancer metastasis without significant SSTR2A expression. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002513DOI Listing
May 2019
10 Reads

Minimally Invasive Surgery-Based Multidisciplinary Clinical Management of Reninoma: A Single-Center Study.

Med Sci Monit 2019 Mar 1;25:1600-1610. Epub 2019 Mar 1.

Department of Urology, State Key Laboratory of Kidney Diseases, Chinese People's Liberation Army (PLA) General Hospital/Chinese PLA Medical Academy, Beijing, China (mainland).

BACKGROUND This article presents our experience in managing a rare kidney tumor - reninoma - by analyzing a relatively large series of cases from a single center. MATERIAL AND METHODS Nine cases of reninoma were reviewed. Clinical manifestations, imaging examinations, laboratory examinations, perioperative data, and pathological findings were summarized. Read More

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https://www.medscimonit.com/abstract/index/idArt/913826
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http://dx.doi.org/10.12659/MSM.913826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407327PMC
March 2019
5 Reads

Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.

Epigenomics 2018 Dec;10(12):1619-1630

Jiangsu Key Laboratory of Molecule Imaging & Functional Imaging, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu, PR China.

Aim: To explore the circular RNA (circRNA) profile of breast cancer brain metastasis (BCBM).

Materials & Methods: RNA-seq was performed to identify the circRNA expression profile of brain metastatic breast cancer cell line 231-BR, in comparison with its parental nonspecific metastatic cell line MDA-MB-231.

Results: A total of 215 upregulated and 191 downregulated circRNAs were identified. Read More

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http://dx.doi.org/10.2217/epi-2018-0090DOI Listing
December 2018

Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice.

Transl Oncol 2019 Apr 23;12(4):640-645. Epub 2019 Feb 23.

AntiCancer, Inc., San Diego, CA, USA; Department of Surgery, University of California, San Diego, CA, USA. Electronic address:

The goal of the present study was to determine the efficacy of osimertinib (AZD9291), a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor for the treatment of aggressive EGFR-mutant non-small cell lung cancer (NSCLC), compared to cisplatinum (CDDP) + pemetrexed (PEM). The NSCLC cell line PC-9 expressing green fluorescence protein (PC-9-GFP) was implanted in the brain of nude mice and was treated with CDDP + PEM or AZD9291. Tumors were observed by non-invasive fluorescence imaging. Read More

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http://dx.doi.org/10.1016/j.tranon.2019.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393699PMC
April 2019
1 Read

Targeting CAIX with [Cu]XYIMSR-06 Small Molecular Radiotracer Enables Noninvasive PET Imaging of Malignant Glioma in U87 MG Tumor Cell Xenograft Mice.

Mol Pharm 2019 Apr 12;16(4):1532-1540. Epub 2019 Mar 12.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine , Peking University Cancer Hospital & Institute , Beijing 100142 , China.

Carbonic anhydrase IX (CAIX) plays an important role in glioma cell proliferation, invasion, metastasis, and resistance to radiotherapy and chemotherapy. An effective and noninvasive PET molecular imaging agent targeting CAIX would help its diagnosis and treatment but is not currently available. Recently, a low-molecular-weight (LMW) CAIX targeting agent, [Cu]XYIMSR-06, was reported to have significantly improved properties for targeting clear cell renal cell carcinoma (ccRCC). Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01210DOI Listing
April 2019
2 Reads

The Dual PI3K/mTOR Pathway Inhibitor GDC-0084 Achieves Antitumor Activity in -Mutant Breast Cancer Brain Metastases.

Clin Cancer Res 2019 Feb 22. Epub 2019 Feb 22.

Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Previous studies have shown that the PI3K/Akt/mTOR pathway is activated in up to 70% of breast cancer brain metastases, but there are no approved agents for affected patients. GDC-0084 is a brain penetrant, dual PI3K/mTOR inhibitor that has shown promising activity in a preclinical model of glioblastoma. The aim of this study was to analyze the efficacy of PI3K/mTOR blockade in breast cancer brain metastases models. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3049DOI Listing
February 2019
2 Reads

Susceptibility-weighted imaging in malignant melanoma brain metastasis.

J Magn Reson Imaging 2019 Feb 21. Epub 2019 Feb 21.

Department of Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany.

Background: The value of cerebral susceptibility-weighted imaging (SWI) in malignant melanoma (MM) patients remains controversial and the effect of melanin on SWI is not well understood.

Purpose: To systematically analyze the spectrum of intracerebral findings in MM brain metastases (BM) on SWI and to determine the diagnostic value of SWI.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.26692DOI Listing
February 2019
2 Reads

Estimation of Gadolinium-based Contrast Agent Concentration Using Quantitative Synthetic MRI and Its Application to Brain Metastases: A Feasibility Study.

Magn Reson Med Sci 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, Juntendo University School of Medicine.

Purpose: Gadolinium-based contrast agents (GBCA) provide valuable information for assessing and differentiating lesions in the body. However, contrast enhancement evaluation on conventional MRI is qualitative because the signal intensity uses an arbitrary scale. An approach that allows more quantitative assessment of tissue enhancement that can be integrated into clinical use is desirable. Read More

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http://dx.doi.org/10.2463/mrms.mp.2018-0119DOI Listing
February 2019
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A rare case of perivascular epithelioid cell tumour metastases to the brain.

SAGE Open Med Case Rep 2019 4;7:2050313X19828539. Epub 2019 Feb 4.

Division of Neurosurgery, Department of Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia.

Perivascular epithelioid cell tumour is a rare mesenchymal tumour with distinct immunohistochemical profile. While it is known to occur in various anatomical sites, the central nervous system had always been a protected site for primary or secondary perivascular epithelioid cell tumours. We describe a 61-year-old lady who presented with symptoms of raised intracranial pressure, 3 months after the resection of duodenal and thoracic tumours which were histologically consistent with perivascular epithelioid cell tumour. Read More

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http://dx.doi.org/10.1177/2050313X19828539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365988PMC
February 2019

Three-Dimensional Mass Spectrometry Imaging Identifies Lipid Markers of Medulloblastoma Metastasis.

Sci Rep 2019 Feb 18;9(1):2205. Epub 2019 Feb 18.

Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Treatment for medulloblastoma (MB) - the most common malignant pediatric brain tumor - includes prophylactic radiation administered to the entire brain and spine due to the high incidence of metastasis to the central nervous system. However, the majority of long-term survivors are left with permanent and debilitating neurocognitive impairments as a result of this therapy, while the remaining 30-40% of patients relapse with terminal metastatic disease. Development of more effective targeted therapies has been hindered by our lack of understanding of the underlying mechanisms regulating the metastatic process in this disease. Read More

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http://dx.doi.org/10.1038/s41598-018-38257-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379434PMC
February 2019
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Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging.

Eur J Radiol 2019 Mar 8;112:59-64. Epub 2019 Jan 8.

Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Background And Purpose: Conventional magnetic resonance imaging (MRI) is sometimes difficult to distinguish primary central nervous system lymphoma (PCNSL) from other malignant brain tumors effectively. The study aimed to evaluate the diagnostic performance of arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE)-derived permeability parameters to differentiate PCNSL from high-grade glioma (HGG) and brain metastasis.

Materials And Methods: Eight patients with PCNSL, twenty one patients with HGG and six brain metastasis underwent preoperative 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193000
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http://dx.doi.org/10.1016/j.ejrad.2019.01.008DOI Listing
March 2019
7 Reads

Small Cell Lung Cancer with Pituitary Metastasis Presenting as Secondary Adrenal Insufficiency: A Case Report and Literature Review.

Am J Case Rep 2019 Feb 17;20:207-211. Epub 2019 Feb 17.

Department of Endocrinology, University of California San Francisco, San Francisco, CA, USA.

BACKGROUND Pituitary gland metastasis is rarely the initial presentation of metastatic cancer. Most cases of pituitary gland metastasis are asymptomatic with diabetes insipidus being the most common symptomatic presentation. It can rarely present with symptoms of hormone underproduction such as secondary adrenal insufficiency. Read More

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http://dx.doi.org/10.12659/AJCR.913388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388645PMC
February 2019
2 Reads

Evaluation of the sensitivity of Rρ MRI to pH and macromolecular density.

Magn Reson Imaging 2019 May 14;58:156-161. Epub 2019 Feb 14.

Department of Radiology, Box 218, University of Cambridge, Cambridge CB2 0QQ, United Kingdom; Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom, CB2 0QQ. Electronic address:

The tumor microenvironment is characteristically acidic and this extracellular acidosis is known to play a role in carcinogenesis and metastasis and can affect tumor chemosensitivity and radiosensitivity. Intracellular pH has been used as a possible biomarker of salvageable tissue in ischemic stroke. A non-invasive MRI-based approach for the determination and imaging of cerebral pH would be a powerful tool in cancer diagnosis and monitoring, as well as stroke treatment planning. Read More

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http://dx.doi.org/10.1016/j.mri.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422633PMC
May 2019
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Discrimination Between Solitary Brain Metastasis and Glioblastoma Multiforme by Using ADC-Based Texture Analysis: A Comparison of Two Different ROI Placements.

Acad Radiol 2019 Feb 12. Epub 2019 Feb 12.

Department of Radiology, Guangzhou First People's Hospital, Guangzhou Medical University, 1 Panfu Road, Guangzhou, Guangdong 510108, China; Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China. Electronic address:

Rationale And Objectives: To explore the value of texture analysis based on the apparent diffusion coefficient (ADC) value and the effect of region of interest (ROI) placements in distinguishing glioblastoma multiforme (GBM) from solitary brain metastasis (sMET).

Materials And Methods: Sixty-two patients with pathologically confirmed GBM (n = 36) and sMET (n = 26) were retrospectively included. All patients underwent diffusion-weighted imaging with b values of 0 and 1000 s/mm, and the ADC maps were generated automatically. Read More

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http://dx.doi.org/10.1016/j.acra.2019.01.010DOI Listing
February 2019
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Meningeal Metastasis Relapse With Focal Involvement of Cranial Bone Flap: A Case Resolved by 18F-DOPA PET/MRI.

Clin Nucl Med 2019 Apr;44(4):e315-e317

From the SyMPTOm PET/MRI Platform, Nuclear Medicine Department, and.

A 63-year-old woman was referred to our PET/MRI platform to evaluate the possible relapse of a meningeal metastasis, complicating an invasive ductal carcinoma of the left breast. This metastasis was diagnosed on a left hemiparesis and treated by surgery and radiation therapy. One year later, the same symptoms led to another brain MRI examination that found a contrast-enhanced lesion in the operating site. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002492DOI Listing

Early postoperative MRI after resection of brain metastases-complete tumour resection associated with prolonged survival.

Acta Neurochir (Wien) 2019 Mar 13;161(3):555-565. Epub 2019 Feb 13.

Department of Neurosurgery, Odense University Hospital, Sdr. Boulevard 29, 5000, Odense, Denmark.

Background: This study aimed to investigate the incidence of residual tumour after resection of brain metastases using early postoperative magnetic resonance imaging (MRI) and the influence of residual tumour on overall patient survival.

Methods: Data from 72 consecutive adult patients undergoing surgery for cerebral metastases over an 18-month study period were retrospectively collected. Early postoperative MRI was used to determine the presence of postoperative residual tumour. Read More

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http://dx.doi.org/10.1007/s00701-019-03829-0DOI Listing
March 2019
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Stereotactic-Guided Dilatable Endoscopic Port Surgery for Deep-Seated Brain Tumors: Technical Report with Comparative Case Series Analysis.

World Neurosurg 2019 Feb 8. Epub 2019 Feb 8.

Lexington Brain and Spine Institute, Lexington Medical Center, Columbia, South Carolina, USA. Electronic address:

Objective: Deep-seated brain tumors are often best treated by primary surgical excision. Traditional microsurgical techniques can cause retraction injury and require extensive brain dissection. To mitigate this risk, stereotactic-guided tubular retractors were developed; however, the risk of shear injury remains. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.175DOI Listing
February 2019
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Cellular MRI Reveals Altered Brain Arrest of Genetically Engineered Metastatic Breast Cancer Cells.

Contrast Media Mol Imaging 2019 8;2019:6501231. Epub 2019 Jan 8.

Robarts Research Institute, The University of Western Ontario, London, Ontario, Canada.

Purpose: The combined use of anatomical magnetic resonance imaging (MRI), cellular MRI, and bioluminescence imaging (BLI) allows for sensitive and improved monitoring of brain metastasis in preclinical cancer models. By using these complementary technologies, we can acquire measurements of viable single cell arrest in the brain after systemic administration, the clearance and/or retention of these cells thereafter, the growth into overt tumours, and quantification of tumour volume and relative cancer cell viability over time. While BLI is very useful in measuring cell viability, some considerations have been reported using cells engineered with luciferase such as increased tumour volume variation, changes in pattern of metastatic disease, and inhibition of tumour growth. Read More

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http://dx.doi.org/10.1155/2019/6501231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348811PMC
January 2019

Alpha particle Radium 223 dichloride in high-risk osteosarcoma: a phase I dose escalation trial.

Clin Cancer Res 2019 Feb 7. Epub 2019 Feb 7.

Radiology, Baylor College of Medicine.

Purpose: The prognosis of metastatic osteosarcoma continues to be poor. We hypothesized that alpha-emitting, bone-targeting radium 223 dichloride (RaCl) can be safely administered to patients with osteosarcoma and that early signals of response or resistance can be assessed by quantitative and qualitative correlative imaging studies and biomarkers.

Experimental Design: A 3+3 phase I, dose-escalation trial of RaCl (50, 75, and 100 kBq/kg) was designed in recurrent/metastatic osteosarcoma patients aged ≥15 years. Read More

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-3964DOI Listing
February 2019
8 Reads