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    Recovery of an injured cingulum concurrent with improvement of short-term memory in a patient with mild traumatic brain injury.
    Brain Inj 2017 Nov 15:1-3. Epub 2017 Nov 15.
    a Department of Physical Medicine and Rehabilitation, College of Medicine , Yeungnam University, Daegu, South Korea.
    Objectives: We reported on a patient with mild traumatic brain injury (TBI) who showed recovery of an injured cingulum concurrent with improvement of short-term memory, which was demonstrated on follow-up diffusion tensor tractography (DTT).

    Methods: A 55-year-old male patient suffered head trauma resulting from falling from approximately 2 m while working at a construction site. The patient showed mild memory impairment (especially short-term memory impairment) at 3 months after onset: Memory Assessment Scale (global memory: 95 (37%ile), short-term memory: 75 (5%ile), verbal memory: 80 (9%ile) and visual memory: 112 (79%ile)). Read More

    Investigating ioflupane I(123) injection and single photon emission tomography as an imaging biomarker for long-term sequelae following mild traumatic brain injury.
    Brain Inj 2017 Nov 13:1-8. Epub 2017 Nov 13.
    a Department of Neurology , NorthShore University HealthSystem , Evanston , IL , USA.
    Objective: To determine whether there were differences in clinical outcomes for ioflupane I(123) injection (DaTscan) and single photon emission tomography consistent with early Parkinson's disease (PD) among individuals with a history of mild traumatic brain injury (mTBI).

    Methods: We performed a case-control study among patients presenting to the Emergency Room (ER) during 2006-2013 with mTBI (cases, n = 34) or without mTBI (controls, n = 33). We performed clinical and imaging measurements in cases and controls at least 1-year post-presentation to the ER (average three years four months). Read More

    Longitudinal trajectories of post-concussive and depressive symptoms in adolescents with prolonged recovery from concussion.
    Brain Inj 2017 Nov 8:1-9. Epub 2017 Nov 8.
    a Center for Child Health, Behavior and Development , Seattle Children's Research Institute , Seattle , WA, USA.
    Primary Objective: To investigate the symptom trajectories of depressive and post-concussive symptoms (PCS) in slow-to-recover adolescents to understand how the two sets of symptoms are related.

    Research Design: We used data from a randomized clinical trial of a collaborative care intervention for post-concussive symptoms to better understand how these two sets of symptoms change in parallel over 6 months.

    Methods And Procedure: PCS and depressive symptom scores for 49 adolescents (ages 11-17) were measured at enrolment and after 1, 3, and 6 months. Read More

    Inter- and intra-tester reliability of the acute brain injury physiotherapy assessment (ABIPA) in patients with acquired brain injury.
    Brain Inj 2017 Nov 8:1-8. Epub 2017 Nov 8.
    b Australian Catholic University, (Brisbane Campus) , Brisbane , QLD , Australia.
    Background: The Acute Brain Injury Physiotherapy Assessment (ABIPA) is a new outcome measure with face validity and sensitivity to change in the early stages of neuromotor recovery after acquired brain injury (ABI). Reliability of physiotherapists using the tool has not been established.

    Objective: Determine inter- and intra-tester reliability of physiotherapists using the ABIPA. Read More

    A summary on the effectiveness of the Amsterdam memory and attention training for children (Amat-c) in children with brain injury.
    Brain Inj 2017 Nov 8:1-11. Epub 2017 Nov 8.
    a Department of Neuropsychology & Psychopharmacology , Maastricht University , Maastricht , the Netherlands.
    Objective: To summarise the current research on the effectiveness of the Amsterdam Memory and Attention Training for Children (Amat-c).

    Methods: A literature search was conducted to find articles published about the Amat-c, using PubMed, psychINFO, and PsychBITE databases. Relevant search terms included Amat-c, attention and memory, and childhood ABI. Read More

    Baseline King-Devick scores for adults are not generalizable; however, age and education influence scores.
    Brain Inj 2017 Nov 8:1-7. Epub 2017 Nov 8.
    a Division of Nursing and Health Sciences, Physical Therapy Department , Neumann University , Aston , PA , USA.
    Objective: To establish normative values for the King-Devick (K-D) test to be used as a reference for determining impairment related to concussion when individual baseline scores are lacking.

    Method: Baseline K-D scores were collected for 243 participants aged 18-86.

    Results: The mean age of subjects was 40. Read More

    Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls: a cross sectional study.
    Brain Inj 2017 Nov 2:1-8. Epub 2017 Nov 2.
    a Dept of Clinical Medicine, Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University , Hammel , Denmark.
    Primary Objectives: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms.

    Research Design: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group.

    Methods And Procedures: Diffusion MRI was obtained in 25 patients with extensive PCS and in 25 patients with minimal PCS as measured by the Rivermead Post-concussion Symptoms Questionnaire. Read More

    The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis.
    Brain Inj 2017 Oct 31:1-17. Epub 2017 Oct 31.
    d Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine and Psychiatry , McKnight Brain Institute, University of Florida , Gainesville, Florida, USA.
    Traumatic brain injury (TBI) is a major health concern. The purpose of this study is to identify the diagnostic accuracy of ubiquitin C-terminal hydrolase-L1 (UCH-L1)-a protein biomarker-in comparison with CT-scan findings post-TBI. Accordingly, we conducted a systematic review of eligible studies and assessed the risk of bias according to the QUADAS-2 checklist. Read More

    A novel tool for naturalistic assessment of behavioural dysregulation after traumatic brain injury: A pilot study.
    Brain Inj 2017 Oct 24:1-10. Epub 2017 Oct 24.
    a Department of Rehabilitation Science & Technology , University of Pittsburgh , Pittsburgh , PA , USA.
    Objective: This study aimed to develop a novel tool for measuring behavioural dysregulation in adults with traumatic brain injury (TBI) using objective data sources and real-world application and provide preliminary evidence for its psychometric properties.

    Research Design: Fourteen adults with TBI receiving services at a local brain injury rehabilitation programme completed multiple assessments of behaviour and followed by a series of challenging problem-solving tasks while being video recorded. Trained clinicians completed post-hoc behavioural assessments using the behavioural dysregulation ratings scale, and behavioural event data were then extracted for comparison with self-report measures. Read More

    The effects of tackle height on inertial loading of the head and neck in Rugby Union: A multibody model analysis.
    Brain Inj 2017 Oct 24:1-7. Epub 2017 Oct 24.
    a Trinity Centre for Bioengineering , Trinity College Dublin , Dublin, Ireland.
    Objective: There is evidence of chronic injury to the head-and-neck region of Rugby Union players. The aim of this study was to use multibody simulations to examine the effects of tackle height on both Tackler and Ball Carrier head kinematics and neck dynamics.

    Research Design: Quantitative Exploratory Study Methods and procedures: 45 front-on shoulder tackles with no direct contact to the head/neck were simulated with the MADYMO pedestrian model and used to assess differences between upper body tackles and lower body tackles. Read More

    Introducing the model of cognitive-communication competence: A model to guide evidence-based communication interventions after brain injury.
    Brain Inj 2017 Oct 24:1-21. Epub 2017 Oct 24.
    a Adjunct Lecturer, Department of Speech-Language Pathology , University of Toronto , Toronto , Ontario , Canada.
    Primary Objective: Communication impairments associated with acquired brain injury (ABI) are devastating in their impact on family, community, social, academic, and vocational participation. Despite international evidence-based guidelines for communication interventions, evidence practice gaps include under identification of communication deficits, infrequent referrals, and inadequate treatment to realize functional communication outcomes. Evidence-informed communication intervention requires synthesis of abundant interdisciplinary research. Read More

    Interdisciplinary eHealth for the care of people living with traumatic brain injury: A systematic review.
    Brain Inj 2017 Oct 24:1-10. Epub 2017 Oct 24.
    a Faculty of Health Sciences , The University of Sydney , Lidcombe , NSW , Australia.
    Objective: To identify literature which discusses the barriers and enablers of eHealth technology and which evaluates its role in facilitating interdisciplinary team work for the care of people with a traumatic brain injury (TBI).

    Design: Systematic review.

    Data Sources: Studies were identified by searching CINAHL, Embase, Medline, PsycINFO, Scopus, and Web of Science. Read More

    Evaluation of an active rehabilitation program for concussion management in children and adolescents.
    Brain Inj 2017 Oct 23:1-7. Epub 2017 Oct 23.
    d School of Physical and Occupational Therapy, Montreal Children's Hospital, Montreal University Health Centre, McGill University , Montreal , QC , Canada.
    Objective: To estimate the extent to which post-concussion symptoms were influenced by participation in an Active Rehabilitation (AR) program (aerobic exercise, coordination drills, visualization and education) for children and adolescents who are slow to recover from concussion. A secondary exploratory objective included examining the influence of sex on symptom evolution.

    Methods: Analysis of prospectively collected data was performed on 277 youth who initiated an AR program, between three and four weeks post-injury at a Concussion Clinic in a tertiary care paediatric teaching hospital. Read More

    The occurrence of early impaired self-awareness after traumatic brain injury and its relationship with emotional distress and psychosocial functioning.
    Brain Inj 2017 Oct 23:1-8. Epub 2017 Oct 23.
    c School of Applied Psychology and Menzies Health Institute Queensland , Griffith University , Mt Gravatt , Australia.
    Objective: To describe the occurrence of impaired self-awareness (ISA) after traumatic brain injury (TBI) and its association with emotional distress and psychosocial functioning following discharge.

    Design: Prospective cohort design with data collection at discharge and 1-, 3- and 6-month follow-up.

    Participants: 81 adults with TBI. Read More

    Outcome of traumatic brain injury in patients on antiplatelet agents: a retrospective 20-year observational study in a single neurosurgery unit.
    Brain Inj 2017 9;31(11):1445-1454. Epub 2017 Oct 9.
    a Division of Neurosurgery , National Hospital Organization Disaster Medical Center , Tachikawa , Tokyo , Japan.
    Objective: To evaluate the outcomes after Traumatic Brain Injury (TBI) in patients taking Antiplatelet Agents (APAs).

    Methods: We reviewed the clinical records of 934 patients with TBI between 1995 and 2014. Multivariate analysis was performed to correlate patient outcome with various factors, including pre-injury APA intake. Read More

    Hearing complaints among veterans following traumatic brain injury.
    Brain Inj 2017 ;31(9):1183-1187
    a VA RR&D National Center for Rehabilitative Auditory Research, VA Portland Health Care System , Portland , OR , USA.
    It has been shown that there is an increased risk for impaired auditory function following traumatic brain injury (TBI) in Veterans. Evidence is strongest in the area of self-report, but behavioural and electrophysiological data have been obtained that are consistent with these complaints. Peripheral and central dysfunction have both been observed. Read More

    Traumatic brain injury clinical practice guidelines and best practices from the VA state of the art conference.
    Brain Inj 2017 ;31(9):1246-1251
    c Neurology Department and Uniformed Services University of the Health Sciences , Bethesda , MD , USA.
    Management of symptoms following traumatic brain injury (TBI) can be complex and remains a high priority for Department of Defense (DoD) and Department of Veteran Affairs (VA). Concurrently, awareness of TBI in the public has increased. VA convened a State of the Art (SOTA) Conference to identify priorities for future research and promote best practices for TBI care. Read More

    Neuroimaging of deployment-associated traumatic brain injury (TBI) with a focus on mild TBI (mTBI) since 2009.
    Brain Inj 2017 ;31(9):1204-1219
    c Translational Research Center for TBI and Stress Disorders (TRACTS) , VA Boston Healthcare System , Boston , MA , USA.
    Objectives: A substantial body of recent research has aimed to better understand the clinical sequelae of military trauma through the application of advanced brain imaging procedures in Veteran populations. The primary objective of this review was to highlight a portion of these recent studies to demonstrate how imaging tools can be used to understand military-associated brain injury.

    Methods: We focus here on the phenomenon of mild traumatic brain injury (mTBI) given its high prevalence in the Veteran population and current recognition of the need to better understand the clinical implications of this trauma. Read More

    The need for VA leadership in advancing traumatic brain injury care.
    Brain Inj 2017 ;31(9):1252-1255
    a Professor of Neurology , Division of Neurocritical Care The Johns Hopkins Hospital 600 N. Wolfe St., Phipps 455 Baltimore , MD 21287.
    Traumatic brain injury (TBI) afflicts veterans, active duty service members and the civilian community. An estimated 5.3 million US men, women, and children live with a permanent TBI-related disability. Read More

    Injury cascades in TBI-related neurodegeneration.
    Brain Inj 2017 ;31(9):1177-1182
    b Department of Clinical and Health Psychology, Neuropsychology , College of Public Health and Health Professions, University of Florida , Gainesville FL , USA.
    Traumatic brain injury (TBI) is a widely recognized risk factor for neurodegenerative disease. The purpose of this review is to provide an update on the state of the science related to injury cascades in TBI-related neurodegeneration. Acute and chronic pathological outcomes of TBI are similar to those seen in several neurodegenerative conditions, suggesting common linking pathways. Read More

    Impact of TBI on caregivers of veterans with TBI: Burden and interventions.
    Brain Inj 2017 ;31(9):1235-1245
    h Miami Shores , FL , USA.
    Objectives: Describe State-of-the-Art in practice and research in caregiving with individuals, specifically, Veterans with traumatic brain injury (TBI) and the implications for current practice and future research.

    Sources: Professional literature and personal experience of review panel.

    Main Outcomes: Unpaid caregiving for individuals with TBI is most often provided by a spouse, parent or other blood relative; the majority of caregivers are women. Read More

    Health services and rehabilitation for active duty service members and veterans with mild TBI.
    Brain Inj 2017 ;31(9):1220-1234
    g South Texas Veterans Healthcare System , San Antonio , Texas , USA.
    Objective: We review health services and reintegration practices that contribute to the rehabilitation of US active duty service members (ADSMs) and Veterans who experienced traumatic brain injury (TBI), especially mild TBI (mTBI), as discussed at the 2015 Department of Veterans Affairs (VA) TBI State-of-the-Art (SOTA) Conference.

    Methodology: We reviewed the state-of-the-art at the time of the previous 2008 TBI SOTA Conference, advances in the field since then, and future directions to address gaps in knowledge.

    Main Results: We reviewed: (1) mTBI and its comorbid conditions documented in ADSMs and Veterans, and recognized the need for additional healthcare utilization, health cost and quality of care studies; (2) VA vocational rehabilitation programmes and the effectiveness of supported employment for helping those with workplace difficulties; (3) the application of technology to assist in TBI rehabilitation, including mobile device applications for self-management, videoconferencing with providers, and virtual reality to help with behavioural and cognitive challenges, and (4) Department of Defense (DoD)-VA partnerships on identification, evaluation and dissemination of TBI best practices. Read More

    Biofluid biomarkers of traumatic brain injury.
    Brain Inj 2017 ;31(9):1195-1203
    c VA Northwest Network Mental Illness Research, Education, and Clinical Center , Veterans Affairs Puget Sound Health Care System , Seattle , WA , USA.
    Primary Objective: The purpose of this paper is to review the clinical and research utility and applications of blood, cerebrospinal fluid (CSF), and cerebral microdialysis biomarkers in traumatic brain injury (TBI).

    Research Design: Not applicable.

    Methods And Procedures: A selective review was performed on these biofluid biomarkers in TBI. Read More

    Vestibular consequences of mild traumatic brain injury and blast exposure: a review.
    Brain Inj 2017 ;31(9):1188-1194
    a Vestibular Laboratory, James H. Quillen VA Medical Center , Mountain Home , Tennessee , USA.
    The purpose of this article is to review relevant literature on the effect of mild traumatic brain injury (mTBI) and blast injury on the vestibular system. Dizziness and imbalance are common sequelae associated with mTBI, and in some individuals, these symptoms may last for six months or longer. In war-related injuries, mTBI is often associated with blast exposure. Read More

    Preclinical modelling of militarily relevant traumatic brain injuries: Challenges and recommendations for future directions.
    Brain Inj 2017 ;31(9):1168-1176
    s Branch of Brain Trauma Neuroprotection and Neurorestoration, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research ; Silver Spring , MD , USA.
    As a follow-up to the 2008 state-of-the-art (SOTA) conference on traumatic brain injuries (TBIs), the 2015 event organized by the United States Department of Veterans Affairs (VA) Office of Research and Development (ORD) analysed the knowledge gained over the last 7 years as it relates to basic scientific methods, experimental findings, diagnosis, therapy, and rehabilitation of TBIs and blast-induced neurotraumas (BINTs). The current article summarizes the discussions and recommendations of the scientific panel attending the Preclinical Modeling and Therapeutic Development Workshop of the conference, with special emphasis on factors slowing research progress and recommendations for ways of addressing the most significant pitfalls. Read More

    Mirror efficiency in the assessment of visual pursuit in patients in minimally conscious state.
    Brain Inj 2017 5;31(11):1429-1435. Epub 2017 Oct 5.
    d Psychology and Neuroscience of Cognition Research Unit , University of Liège , Liège , Belgium.
    Objective: Visual pursuit should be tested with a mirror in patients with disorders of consciousness. This stimulus was indeed more efficient than a person or an object, and the auto-referential aspect was supposed to be the key feature. The present study tested the hypothesis that the mirror was more efficient because of its self-aspect. Read More

    Hospitalization in low-level trauma centres after severe traumatic brain injury: review of a population-based emergency department data base.
    Brain Inj 2017 5;31(11):1486-1493. Epub 2017 Oct 5.
    a Trauma Service, Division of General Surgery, Department of Surgery , Medical University of South Carolina , Charleston , SC , USA.
    Objective: To achieve the best possible recovery, individuals with severe TBI should be treated at Level I/II trauma centres (I/II TC). Increased morbidity and mortality can result when injured patients are admitted to facilities that may not have the appropriate resources or expertise to treat the injury. The purpose of this study was to estimate the proportion of severe TBI visits resulting in hospitalization in lower-level trauma centres (OTH) and evaluate the characteristics associated with such hospitalizations. Read More

    Attention-deficit/hyperactivity disorder is associated with baseline child sport concussion assessment tool third edition scores in child hockey players.
    Brain Inj 2017 5;31(11):1479-1485. Epub 2017 Oct 5.
    a Department of Psychiatry , University of British Columbia , Vancouver , Canada.
    Objectives: The objectives of this study were to report baseline, preseason data for the Child-SCAT3, stratified by attention deficit hyperactivity disorder (ADHD) status, and examine group differences in Child-SCAT3 performance between children with and without ADHD.

    Design: Cross-sectional study.

    Methods: Young male hockey players (n = 304), aged 8-12 years, were administered the Child-SCAT3 during pre-season. Read More

    Does the fear avoidance model explain persistent symptoms after traumatic brain injury?
    Brain Inj 2017 5;31(12):1597-1604. Epub 2017 Oct 5.
    a Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience , Maastricht University , Maastricht , the Netherlands.
    Background: A minority of patients with mild traumatic brain injury (mTBI) experience a persistent symptom complex also known as post-concussion syndrome. Explanations for this syndrome are still lacking.

    Objective: To investigate if the fear avoidance model, including catastrophizing thoughts and fear avoidance behaviour, poses a possible biopsychosocial explanation for lingering symptoms and delay in recovery after traumatic brain injury (TBI) with special focus on mTBI. Read More

    Psychometric properties of the awareness questionnaire, patient competency rating scale and Dysexecutive Questionnaire in patients with acquired brain injury.
    Brain Inj 2017 5;31(11):1469-1478. Epub 2017 Oct 5.
    a Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience , Maastricht University Medical Center , Maastricht , the Netherlands.
    Objective: Lack of self-awareness of impairments is common after acquired brain injury (ABI). We evaluated the psychometric properties of three commonly used instruments for measuring self-awareness: Awareness Questionnaire (AQ), Patient Competency Rating Scale (PCRS) and Dysexecutive questionnaire (DEX).

    Method: We recruited 105 patients with ABI and their relatives. Read More

    Dizziness-related disability following mild-moderate traumatic brain injury.
    Brain Inj 2017 3;31(11):1436-1444. Epub 2017 Oct 3.
    a Dept. of Physical Medicine and Rehabilitation , Oslo University Hospital HF , Oslo , Norway.
    Objective: To investigate the associations between dizziness-related disability after mild- moderate Traumatic Brain Injury (TBI) and personal factors, injury-related factors and post-injury functioning using the International Classification of Functioning, Disability and Health (ICF) as a framework.

    Methods: Baseline assessments for a Randomised Controlled Trial (RCT) were obtained for 65 patients (mean age 39.2 years; SD 12. Read More

    Brain-Derived Microparticles in Patients with Severe Isolated TBI.
    Brain Inj 2017 Oct 3:1-7. Epub 2017 Oct 3.
    c Karolinska Institutet , Department of Clinical Sciences, Division of Cardiovascular Medicine, Danderyds Hospital , Stockholm , Sweden.
    Primary Objective: to investigate the presence of circulating microparticles (MPs) of brain tissue origin in the systemic and cerebrovenous blood of patients with severe traumatic brain injury (TBI).

    Research Design: Prospective observational study in 15 consecutive patients with severe isolated TBI.

    Methods And Procedures: We repeatedly measured concentrations of MPs expressing glial fibrillary acidic protein (GFAP), neuron-specific enolase (NSE) and aquaporin-4 (AQP4), in arterial and cerebrovenous blood at admittance to hospital and up to 72 hours after the injury. Read More

    Staying in the game: a pilot study examining the efficacy of protective headgear in an animal model of mild traumatic brain injury (mTBI).
    Brain Inj 2017 3;31(11):1521-1529. Epub 2017 Oct 3.
    a Hotchkiss Brain Institute , University of Calgary , Calgary AB.
    Primary Objective: Rugby is one of the few contact sports that do not mandate protective headgear, possibly because studies have shown poor efficacy for protection related to concussion pathology with existing headguards.

    Research Design: Following innovative material technology utilization to produce headgear believed to have protective capabilities, this study examined the effects of a soft-shell headgear constructed from a novel viscoelastic material, on both behaviour and serum biomarkers after high and average impact force mild traumatic brain injuries (mTBI).

    Methods And Procedures: Seventy-five male Sprague Dawley rats were divided into five groups: control, average - 37G impact, with and without headgear, and high - 106G impact, with and without headgear. Read More

    Intranasal Nerve Growth Factor administration improves cerebral functions in a child with severe traumatic brain injury: A case report.
    Brain Inj 2017 3;31(11):1538-1547. Epub 2017 Oct 3.
    f Pediatric Oncology , Università Cattolica del Sacro Cuore , Rome , Italy.
    Background: Nerve growth factor (NGF) promotes neural recovery after experimental traumatic brain injury (TBI) supporting neuronal growth, differentiation and survival of brain cells and up-regulating the neurogenesis-associated protein Doublecortin (DCX). Only a few studies reported NGF administration in paediatric patients with severe TBI.

    Methods: A four-year-old boy in a persistent unresponsive wakefulness syndrome (UWS) was treated with intranasal murine NGF administration 6 months after severe TBI. Read More

    Traumatic axonal injury despite clinical phenotype of mild traumatic brain injury: a case report.
    Brain Inj 2017 28;31(11):1534-1537. Epub 2017 Sep 28.
    a Department of Physical Medicine and Rehabilitation , College of Medicine, Yeungnam University , Taegu , Republic of Korea.
    Objectives: We report on a patient who suffered traumatic axonal injury (TAI) of various neural tracts despite airbag deployment following mild traumatic brain injury (TBI), which was demonstrated by diffusion tensor tractography (DTT).

    Case Description: A 58-year-old female patient suffered from head trauma resulting from an in-car traffic accident. At the time of head trauma, her head and face hit the deployed airbag after flexion-hyperextension-rotation injury. Read More

    Getting clocked: screening for TBI-related cognitive impairment with the clock drawing test.
    Brain Inj 2017 28;31(11):1501-1506. Epub 2017 Sep 28.
    a Department of Psychiatry , Sunnybrook Research Institute , Toronto , ON , Canada.
    Primary Objective: Undetected cognitive impairment resulting from Traumatic Brain Injuries (TBIs), particularly the 75-95% classified as mild (mTBI), poses a significant public health challenge as untreated symptoms, can persist and cause lasting disability. These cognitive deficits are often missed by standard screening tests, creating a need for alternative cognitive screening tools. The Clock Drawing Test (CDT), a popular, brief cognitive screening instrument, was used to evaluate cognition in persons with TBI. Read More

    Effectiveness of central plus peripheral stimulation (CPPS) on post stroke upper limb motor rehabilitation.
    Brain Inj 2017 28;31(11):1494-1500. Epub 2017 Sep 28.
    a Department of Physical Therapy, Faculty of Applied Medical Science , King Abdulaziz University , Jeddah , Saudi Arabia.
    Purpose: This study was to assess the motor-cortex integrity and reaction time of the upper limb in patients early after stroke after CPPS approach with Theta Burst Stimulation (TBS) an repetitive Trans-cranial Magnetic Stimulation (TMS) paradigm and Neuromuscular Electrical Stimulation (NMES).

    Methods: Ten patients and ten age matched controls underwent three experimental sessions in three consecutive weeks. First-week W1 (TBS) with TBS alone, second-week W2 (NMES) with NMES alone and third-week W3 (TBS + NMES) with both TBS and NMES given sequentially. Read More

    Recovery of an injured prefronto-caudate tract in a patient with traumatic brain injury: A diffusion tensor tractography study.
    Brain Inj 2017 28;31(11):1548-1551. Epub 2017 Sep 28.
    a Department of Physical Medicine and Rehabilitation, College of Medicine , Yeungnam University , Namku , Taegu , Republic of Korea.
    Objectives: We report on a patient with improvement of akinetic mutism (AM), who showed recovery of an injured prefronto-caudate tract following traumatic brain injury (TBI), which was demonstrated by follow-up diffusion tensor tractographies (DTTs).

    Case Presentation: A 72-year-old female had suffered from head trauma resulting from falling down the stairs. She was diagnosed as subdural hematoma on the right frontal lobe and subarachnoid haemorrhage. Read More

    Incidence and mortality of acquired brain injury in young Danish adults between 1994 and 2013: a nationwide study.
    Brain Inj 2017 28;31(11):1455-1462. Epub 2017 Sep 28.
    d Research Unit on Brain Injury Rehabilitation Copenhagen (RUBRIC), Department of Neurorehabilitation, TBI Unit, Rigshospitalet , University of Copenhagen , Copenhagen,Denmark.
    Background: We estimated the annually incidence and mortality of acquired brain injury (ABI) in people aged 15-30 years during 1994-2013.

    Methods: All Danes with a first-ever hospital diagnosis of ABI, including traumatic brain injury (TBI), encephalopathy, CNS-infection or brain tumour, were identified in the Danish National Patient Register. Incidence rates (IRs) and estimated annual percentage changes (EAPC) were estimated by Poisson regression. Read More

    Dynamics of clinical recovery during the early phase of rehabilitation in patients with severe traumatic and non-traumatic brain injury.
    Brain Inj 2017 28;31(11):1463-1468. Epub 2017 Sep 28.
    a Pôle Anesthésie Réanimation, Hôpital Michallon , CHU Grenoble Alpes , Grenoble , France.
    Purpose: Our aim was to describe the changes in the functional outcome at the early phase of rehabilitation following severe brain injury and to identify the factors associated with faster recovery.

    Methods: This retrospective analysis included 182 patients who were transferred from the intensive care unit (ICU) to a post-ICU neurorehabilitation unit following traumatic brain injury (TBI) (n = 82) or cerebrovascular accident (CVA) (n = 100). Admission, discharge and changes in scores were calculated for the Functional Independent Measurement (FIM) and the Wessex Head Injury Matrix (WHIM). Read More

    Hypereosinophilic syndrome with central nervous system involvement: Two case reports and literature review.
    Brain Inj 2017 25;31(12):1695-1700. Epub 2017 Sep 25.
    a Department of Neurology , The Affiliated Hospital of Xuzhou Medical University , Xuzhou , China.
    Objective: To report two cases of hypereosinophilic syndrome (HES) with central nervous system involvement and explore its possible pathogenesis.

    Methods: We have analysed the clinical data and relevant features of two patients who presented themselves to The Affiliated Hospital of Xuzhou Medical University between 2012 and 2015. We have reviewed the relevant literature, elaborated the possible pathogenesis, and discussed the treatment options. Read More

    Language and cognitive communication disorder during post-traumatic amnesia: Profiles of recovery after TBI from three cases.
    Brain Inj 2017 Sep 25:1-14. Epub 2017 Sep 25.
    b Speech Pathology , The University of Sydney , Sydney , Australia.
    Background: There has been limited empirical speech-language pathology (SLP) study of language and cognitive communication during post-traumatic amnesia (PTA) and the early stages after TBI. The purpose of the current research was to explore the potential means and utility of assessing cognitive communication during PTA and the post-acute recovery period.

    Method: This research used a longitudinal mixed methods design to describe language and cognitive communication assessment and recovery profiles of three patients with TBI. Read More

    'Attending to the wound and the person - patients' experiences and expectations of a newly established traumatic brain injury clinic.
    Brain Inj 2017 Sep 25:1-8. Epub 2017 Sep 25.
    a West London Mental Health NHS Trust , London , UK.
    Primary Objective: This qualitative study aimed to gain a better understanding of how medical and social services in the UK currently support patients with Traumatic Brain Injury (TBI) in the community. Furthermore, we explored patients' wishes and expectations of a newly established TBI clinic.

    Methods And Procedures: We conducted semi-structured interviews with 10 patients with mild-to-severe TBI. Read More

    Impact of extended monitoring-guided intensive care on outcome after severe traumatic brain injury: A prospective multicentre cohort study (PariS-TBI study).
    Brain Inj 2017 19;31(12):1642-1650. Epub 2017 Sep 19.
    h Department of Anesthesiology and Intensive Care , Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, University Paris Sud , Le Kremlin Bicêtre , France.
    Objective: We evaluated whether an integrated monitoring with systemic and specific monitoring affect mortality and disability in adults with severe traumatic brain injury (sTBI).

    Methods: Adults with severeTBI (Glasgow Coma Scale [GCS] ≤ 8) admitted alive in intensive care units (ICUs) were prospectively included. Primary endpoints were in-hospital 30-day mortality and extended Glasgow outcome score (GOSE) at 3 years. Read More

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