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    1 OF 71

    The effects of amantadine on traumatic brain injury outcome: a double-blind, randomized, controlled, clinical trial.
    Brain Inj 2018 May 23:1-6. Epub 2018 May 23.
    e Medical doctor, Resident of neurosurgery, Department of Neurosurgery , Iran University of Medical Sciences , Tehran , Iran.
    Introduction: Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI).

    Methods: We performed this study as a double-blind, randomized, controlled clinical trial with target population including all patients with TBI who scored nine or lower on the Glasgow Coma Scale (GCS), admitted to our hospital between January 2013 and April 2014. The protocol included administration of the drug (placebo or amantadine) for 6 weeks and patient evaluation using the GCS and FOUR score on the first, third and seventh days after the drug was started. Read More

    Evaluation of management and guideline adherence in children with mild traumatic brain injury.
    Brain Inj 2018 May 18:1-12. Epub 2018 May 18.
    a Department of Paediatric Neurology , Erasmus University Hospital - Sophia Children's Hospital , Rotterdam , The Netherlands.
    Aim: To evaluate the management and guideline adherence in children with mild traumatic brain injury (MTBI) in emergency departments (ED) in the Netherlands.

    Methods: A multicentre cohort study was conducted, including children younger than 18 years with MTBI who presented within 24 hours after trauma in the ED of hospitals in the southwest region of the Netherlands, in 2014. Primary outcome measures for management were percentages of performed computed tomography (CT) scans and hospital admissions. Read More

    A scoping review of the nature and outcomes of extended rehabilitation programmes after very severe brain injury.
    Brain Inj 2018 May 14:1-11. Epub 2018 May 14.
    a Living with Disability Research Centre , La Trobe University , Bundoora , Victoria , Australia.
    Primary Objective: Many adults with very severe acquired brain injury (ABI) do not receive adequate rehabilitation, limiting their recovery and leading to admission to inappropriate living environments. The aim of this scoping review was to map the existing literature relating to the nature and outcomes of rehabilitation programmes for adults experiencing prolonged recovery after very severe ABI.

    Design: A comprehensive scoping of the literature was undertaken, including systematic searching of databases, grey literature, and hand searching. Read More

    Frequency and prognostic factors of olfactory dysfunction after traumatic brain injury.
    Brain Inj 2018 May 9:1-7. Epub 2018 May 9.
    a Department of Otorhinolaryngology , St. Olavs University Hospital , Trondheim , Norway.
    Objective: To assess the frequency and factors associated with posttraumatic olfactory dysfunction, including anosmia, in a follow-up of patients with moderate and severe traumatic brain injury (TBI).

    Methods: The setting was a cross-sectional study of patients that were consecutively included in the Trondheim TBI database, comprising injury-related variables. Eligible participants 18-65 years were contacted 9-104 months post trauma and asked olfactory-related questions. Read More

    Functional outcomes following post-acute rehabilitation for moderate-to-severe traumatic brain injury.
    Brain Inj 2018 May 8:1-8. Epub 2018 May 8.
    a Traumatic Brain Injury Rehabilitation Department , Park Terrace Care Center , Rego Park , NY , USA.
    Objective: The objective of this study was to examine the benefits of long-term inpatient rehabilitation for individuals with moderate-to-severe traumatic brain injuries (TBIs).

    Methods: Retrospective database review of 67 individuals with moderate-to-severe TBI admitted to a specialised inpatient TBI program. Outcome measures are as follows: (1) functional independence measure + functional assessment measure (FIM+FAM; admission, discharge, change scores); (2) discharge designation (community vs. Read More

    Methylphenidate-mediated motor control network enhancement in patients with traumatic brain injury.
    Brain Inj 2018 May 8:1-10. Epub 2018 May 8.
    a School of Clinical Medicine, Addenbrooke's Hospital, Division of Anaesthesia , University of Cambridge , Cambridge , UK.
    Primary Objective: To investigate functional improvement late (>6 months) after traumatic brain injury (TBI). To this end, we conducted a double-blind, placebo-controlled experimental medicine study to test the hypothesis that a widely used cognitive enhancer would benefit patients with TBI.

    Research Design: We focused on motor control function using a sequential finger opposition fMRI paradigm in both patients and age-matched controls. Read More

    Psychiatric diagnoses of children affected by their parents' traumatic brain injury: the 1987 Finnish Birth Cohort study.
    Brain Inj 2018 May 8:1-8. Epub 2018 May 8.
    d Department of Psychiatry , Oulu University Hospital , Oulu , Finland.
    Objective: To investigate whether parental TBI increases the overall risk for psychiatric disorders and the risk for specific psychiatric diagnoses in the children affected by parental TBI.

    Methods: The 1987 Finnish Birth Cohort (n = 59 476) were followed up through national registers from birth to the end of 2008. The diagnoses of cohort members and their parents were obtained from the Care Register of Health Care, provided by the National Institute of Health and Welfare. Read More

    Psychological and behavioural difficulties following severe TBI in adolescence: a comparison with a sample of peers with brain lesions of other origin and with a control group.
    Brain Inj 2018 May 8:1-10. Epub 2018 May 8.
    a Neurophysiatric Department , 'Eugenio Medea' Scientific Institute , Lecco , Bosisio Parini , Italy.
    Objective: To describe behavioural and adjustment problems in a group of 57 adolescents with severe traumatic brain injury (TBI) and compare them with a clinical group of peers with brain lesions of other origin (N = 33) and a control group of healthy adolescents (N = 48).

    Methods: All subjects received an age-appropriate assessment, including the child behaviour checklist (CBCL) 4/18, the strengths and difficulties questionnaire (SDQ) and the vineland adaptive behaviour scales (VABS).

    Results: Compared with healthy peers, adolescents with TBI presented with more marked behavioural problems on most CBCL scales (Internalization and Externalization domains were both affected) and on the SDQ Hyperactivity and Peer problems scales. Read More

    The effect of donepezil on the cognitive ability early in the course of recovery from traumatic brain injury.
    Brain Inj 2018 May 8:1-8. Epub 2018 May 8.
    c Department of Physical Medicine and Rehabilitation , University of Alabama at Birmingham.
    Objective: To investigate the effect of donepezil on cognitive ability in patients who have sustained a traumatic brain injury (TBI). We hypothesized that donepezil, an acetylcholinesterase inhibitor, would enhance cognitive recovery beyond that of usual care in an acute rehabilitation facility.

    Methods: This retrospective, longitudinal analysis included 55 patients who were non-randomly prescribed donepezil during acute care and compared them to 74 patients who received usual rehabilitation treatment. Read More

    Financial hardship after traumatic brain injury: a brief scale for family caregivers.
    Brain Inj 2018 May 2:1-7. Epub 2018 May 2.
    a Department of Counseling, School, and Educational Psychology , University at Buffalo , Buffalo , NY , USA.
    Objective: Financial hardship is frequently posited as a significant factor influencing family health and adjustment after brain injury, though traditional methods of measurement have shown limited usefulness. The purpose of this study was to adapt and test the utility of a brief scale of financial hardship (BSFH-BI) for use with family caregivers after TBI.

    Methods: The researchers constructed the BSFH-BI using financial well-being items adapted from three survey instruments. Read More

    Extra practice outside therapy sessions to maximize training opportunity during inpatient rehabilitation after traumatic brain injury.
    Brain Inj 2018 May 2:1-11. Epub 2018 May 2.
    a Department Brain Injury Unit , Royal Rehab , Sydney , Australia.
    Objective: To determine if extra practice outside therapy sessions can be conducted for patients with traumatic brain injury and identify factors that influence their participation.

    Methods: A purpose-designed survey was conducted on consecutive eligible patients with traumatic brain injury and their relatives on discharge from inpatient rehabilitation.

    Results: In total, 68 of the 69 of patients who took part in the survey reported that they participated in extra practice outside therapy sessions. Read More

    Therapy influences goal attainment following botulinum neurotoxin injection for focal spasticity in adults with neurological conditions.
    Brain Inj 2018 May 2:1-9. Epub 2018 May 2.
    a Physiotherapy Department , Epworth HealthCare , Melbourne , Australia.
    Objective: To determine whether therapy influenced goal attainment following botulinum toxin (BoNT-A) injection for focal spasticity in adults with neurological conditions.

    Methods: A prospective observational cohort study conducted in a large metropolitan spasticity clinic on adults with focal spasticity of any origin. Participants were provided with a therapy programme, designed to maximise therapeutic outcome. Read More

    Prevalence and predictors of tobacco smoking in veterans and service members following traumatic brain injury rehabilitation: a VA TBIMS study.
    Brain Inj 2018 Apr 30:1-6. Epub 2018 Apr 30.
    a Mental Health and Behavioral Sciences Section (MHBSS) , James A. Haley Veterans' Hospital , Tampa , FL , USA.
    Objective: To identify prevalence and predictors of tobacco smoking among veterans and military service members (V/SM) with traumatic brain injury (TBI) admitted for rehabilitation.

    Methods: Participants were drawn from the VA TBI Model Systems multicentre longitudinal research study. Tobacco smoking was assessed both preinjury and at 1- or 2-year post-TBI follow-up for 336 participants. Read More

    Psychological well-being in individuals living in the community with traumatic brain injury.
    Brain Inj 2018 Apr 30:1-6. Epub 2018 Apr 30.
    d Psychology Department , University of Utah , Salt Lake City , UT , USA.
    Background: Well-being and quality of life issues remain a long-term problem for many individuals with traumatic brain injury (TBI). Meaningful activity is key to developing life satisfaction and a sense of contribution to society, yet individuals with TBI are often unable to return to competitive employment.

    Objective: To describe the self-reported psychological well-being of a cohort of unemployed individuals living in the community at least 1 year post TBI with low life satisfaction. Read More

    Outcomes of protocolised analgesia and sedation in a neurocritical care unit.
    Brain Inj 2018 Apr 30:1-7. Epub 2018 Apr 30.
    f Neurologist, Division of Neurocritical Care, Departments of Neurology and Neurosurgery , Rhode Island Hospital , Providence , RI , USA.
    Objectives: Providing analgesia and sedation while allowing for neurological assessment is important in the neurocritical care unit (NCCU), yet data are limited about the effects of protocolised analgesia and sedation. We developed an analgesia-based sedation protocol and evaluated its effect on medication utilisation and costs in the NCCU.

    Methods: We conducted a retrospective cohort study of patients who are mechanically ventilated and admitted to a 12-bed NCCU over four years. Read More

    Intracranial pressure changes after mild traumatic brain injury: a systematic review.
    Brain Inj 2018 Apr 27:1-7. Epub 2018 Apr 27.
    f Department of Psychiatry , State University of New York , Buffalo , USA.
    Objective: Intracranial pressure (ICP) after mild traumatic brain injury (mTBI) is poorly studied due to lack of sensitive non-invasive methods. The purpose of this review was to summarize the existing knowledge of changes in ICP after mTBI. Literature selection: PubMed, Embase, CINAHL, and Scopus were searched by three reviewers independently up to December 2016. Read More

    Change in body mass index within the first-year post-injury: a VA Traumatic Brain Injury (TBI) model systems study.
    Brain Inj 2018 Apr 27:1-8. Epub 2018 Apr 27.
    a Center of Innovation for Disability and Rehabilitation Research , James A. Haley Veterans Hospital , Tampa , FL , USA.
    Objective: To describe change in body mass index (BMI) and weight classification 1-year post- traumatic brain injury (TBI) among Veterans and service members.

    Design: Prospective observational cohort study.

    Setting: VA Polytrauma Rehabilitation Centers. Read More

    Family Forward: a social work clinical trial promoting family adaptation following paediatric acquired brain injury.
    Brain Inj 2018 Apr 25:1-12. Epub 2018 Apr 25.
    a The Royal Children's Hospital, University of Melbourne , Melbourne , Australia.
    Objective: To test the efficacy of a family intervention Family Forward in promoting early adaptation following a child's acquired brain injury (ABI).

    Research Design: Prospective, sequential comparison group design.

    Methods And Procedures: Families of children (n = 47) diagnosed with ABI received Family Forward (n = 25): two family counselling sessions plus optional multi-family group session per week or Usual Care (n = 22) during their child's inpatient rehabilitation admission. Read More

    Validation of the QOLIBRI - Quality of Life after Brain Injury questionnaire in patients after TBI in Israel.
    Brain Inj 2018 Apr 24:1-10. Epub 2018 Apr 24.
    c Department of Medical Psychology -and Medical Sociology , Georg-August University , Göttingen , Germany.
    Background: The QOLIBRI - Quality of Life after Brain Injury questionnaire was developed by the QOLIBRI Task Force (QTF). Our goal was to investigate the applicability, validity and reliability of the QOLIBRI in Israel.

    Methods: Validation of the Hebrew questionnaire was performed after it had been administered to 128 adults with traumatic brain injury (TBI), who were between 3 months' and 15 years' post-discharge from rehabilitation. Read More

    Effect of distance caregiver coaching on functional skills of a child with traumatic brain injury.
    Brain Inj 2018 Apr 24:1-6. Epub 2018 Apr 24.
    d Communication Sciences & Disorders, James Madison University , Harrisonburg , Virginia , USA.
    Objective: To assess the effect of distance caregiver coaching on skill acquisition of a child with traumatic brain injury. Interactions between caregivers and persons with brain injury may play a critical role in the rehabilitation process, and coaching caregivers is one method that may foster more positive functional outcomes for the individual as caregiver skills may generalize across domains.

    Method: This study utilised a single-subject, multiple baseline across behaviours design to examine the effects of caregiver behaviours on skill acquisition by a child with a traumatic brain injury. Read More

    Six-year review of traumatic brain injury in a regional trauma unit: demographics, contributing factors and service provision in Ireland.
    Brain Inj 2018 Apr 23:1-7. Epub 2018 Apr 23.
    a Department of Surgery , University Hospital Galway , Galway , Ireland.
    Background: Traumatic brain injury (TBI) represents a significant burden of care for acute surgical services, particularly in the absence of on-site neurosurgical cover or sufficient post-acute rehabilitation facilities. We examine factors contributing to TBI, prolonged lengths of stay (LoS) and implications for hospital resources. Long-term outcomes are assessed. Read More

    Healthcare providers' attitudes and behaviours related to paediatric mild traumatic brain injury: results from the 2014 DocStyles survey.
    Brain Inj 2018 Apr 23:1-5. Epub 2018 Apr 23.
    b Social marketing, ICF , Rockville , MD.
    Objective: Explore healthcare providers' experiences managing mTBI and better understand their use of mTBI assessment tools and guidelines. Cross-sectional Methods: A random sample of 1,760 healthcare providers responded to the web-based DocStyles survey between June 18 and 30, 2014. The sample included family/general practitioners, internists, pediatricians, and nurse practitioners who reported seeing pediatric patients. Read More

    Cognitive profiles of older adults with a prior traumatic brain injury versus healthy controls: A meta-analysis.
    Brain Inj 2018 Apr 20:1-11. Epub 2018 Apr 20.
    a Department of Psychology , University of Windsor , Windsor , ON , Canada.
    Objective: To determine cognitive outcomes in older adults (≥ 50 years old) having sustained a traumatic brain injury (TBI) using meta-analysis.

    Methods: MedLine and PsycInfo databases were searched to identify studies comparing neuropsychological profiles in older adults with and without a history of TBI across various injury severities and times post-injury. Ten studies (n = 717) meeting inclusion criteria were identified. Read More

    Living and ageing with stroke: an exploration of conditions influencing participation in social and leisure activities over 15 years.
    Brain Inj 2018 Apr 19:1-9. Epub 2018 Apr 19.
    a Department of Health Sciences , Lund University , Lund , Sweden.
    Objective: To explore conditions influencing long-term participation in social and leisure activities among people who have had a stroke.

    Methods: This study had a qualitative design, using a grounded theory methodology. Data collection was based on in-depth interviews performed 15 years after a first-ever stroke with 10 persons recruited from a population-based stroke cohort in Sweden. Read More

    Time use and physical activity in a specialised brain injury rehabilitation unit: an observational study.
    Brain Inj 2018 Apr 18:1-8. Epub 2018 Apr 18.
    b School of Public Health, The University of Sydney , Sydney , Australia.
    Objectives: To determine what is the use of time and physical activity in people undertaking inpatient rehabilitation in a specialised brain injury unit. To determine participants' level of independence related to the use of time and physical activity.

    Methods: Design: Cross-sectional observation study. Read More

    'Reported concussion' time trends within two national health surveys over two decades.
    Brain Inj 2018 Apr 13:1-7. Epub 2018 Apr 13.
    b Perinatal Epidemiology Research Unit, Department of Pediatrics, Department of Obstetrics and Gynaecology , Dalhousie University , Halifax , Nova Scotia , Canada.
    Background: An 'epidemic' of concussions has been widely reported. We examined the annual incidence of reported concussion or other brain injury, over 20 years within Canada in order to explore the magnitude of this reported epidemic.

    Methods: Two Canadian nationally representative health surveys have serially collected injury data associated with disability. Read More

    A systematic review of neuroimaging findings in children and adolescents with sports-related concussion.
    Brain Inj 2018 Apr 12:1-16. Epub 2018 Apr 12.
    a Department of Psychiatry, Geisel School of Medicine at Dartmouth , Dartmouth-Hitchcock Medical Center , Lebanon , NH , USA.
    Background: Sport-related concussion (SRC) generally does not result in structural anomalies revealed through clinical imaging techniques such as MRI and CT. While advanced neuroimaging techniques offer another avenue to investigate the subtle alterations following SRC, the current pediatric literature in this area has yet to be reviewed. The aim of this review is to systematically explore the literature on magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), functional magnetic resonance imaging (fMRI), and cortical thickness following SRC in children and adolescents. Read More

    Searching for effective components of cognitive rehabilitation for children and adolescents with acquired brain injury: A systematic review.
    Brain Inj 2018 5;32(6):679-692. Epub 2018 Apr 5.
    a Department of Neuropsychology and Psychopharmacology, Faculty of Psychology and Neuroscience , Maastricht University , Maastricht , The Netherlands.
    Aim: Cognitive rehabilitation is of interest after paediatric acquired brain injury (ABI). The present systematic review examined studies investigating cognitive rehabilitation interventions for children with ABI, while focusing on identifying effective components. Components were categorized as (1) metacognition and/or strategy use, (2) (computerized) drill-based exercises, and (3) external aids. Read More

    Treadmill associated head injuries on the rise: an 18 year review of U.S. emergency room visits.
    Brain Inj 2018 30;32(6):800-803. Epub 2018 Mar 30.
    b Department of Surgery , University of Nevada Las Vegas School of Medicine , Las Vegas , NV , USA.
    Objective: The treadmill is the most commonly used aerobic exercise equipment with studies showing many gym-related injuries are attributed to treadmills. The purpose of this study is to examine the incidence of treadmill-associated head injuries within the US.

    Methods: Retrospective data from 1997 to 2014 was collected via the National Electronic Injury Surveillance System, which provides annual es7timates of injuries associated with consumer products. Read More

    Vestibular and oculomotor findings in neurologically-normal, non-concussed children.
    Brain Inj 2018 27;32(6):794-799. Epub 2018 Mar 27.
    a Division of Emergency Medicine , The Children's Hospital of Philadelphia , Philadelphia , PA , USA.
    Objective: To determine the proportion of non-concussed, neurologically normal children with failures on a vestibular and oculomotor examination for concussion performed in an acute setting.

    Design: This was a cross-sectional study of subjects 6-18 years old presenting to a paediatric emergency department with non-neurologic chief complaints. The examination was administered by a paediatric emergency medicine physician, and includes assessments of dysmetria, nystagmus, smooth pursuits, saccades, gaze stability, near-point of convergence, and gait/balance testing. Read More

    Comparison of intensive versus conventional insulin therapy in traumatic brain injury: a meta-analysis of randomized controlled trials.
    Brain Inj 2018 26;32(6):693-703. Epub 2018 Mar 26.
    b Department of Anesthesiology and Critical Care Medicine , The Johns Hopkins Hospital , Baltimore , Maryland , USA.
    Objective: To compare intensive insulin therapy (IIT) and conventional insulin therapy (CIT) on clinical outcomes of patients with traumatic brain injury (TBI).

    Methods: MEDLINE, EMBASE, Google Scholar, ISI Web of Science, and Cochrane Library were systematically searched for randomized controlled trials (RCTs) comparing IIT to CIT in patients with TBI. Study-level characteristics, intensive care unit (ICU) events, and long-term functional outcomes were extracted from the articles. Read More

    Music interventions in disorders of consciousness (DOC) - a systematic review.
    Brain Inj 2018 22;32(6):704-714. Epub 2018 Mar 22.
    a Department of Music , Carl von Ossietzky University , Oldenburg , Germany.
    Objectives: The effects of music interventions including active and receptive music therapy for people living with neurogenic disorders of consciousness (DOC) have been subject to empirical studies in the past. The aim of this systematic review was to find and analyse the current research about the effects of musical interventions on people with DOC.

    Methods: For this purpose, studies with music interventions and patients with DOC from the year 1900 to 2017 were searched in English, German, and French in different databases. Read More

    An investigation of white matter integrity and attention deficits following traumatic brain injury.
    Brain Inj 2018 22;32(6):776-783. Epub 2018 Mar 22.
    a School of Psychological Sciences , Monash University , Melbourne , Australia.
    Objective: This study aimed to investigate the association between white matter tracts and multiple aspects of attention and working memory deficits in a relatively acute traumatic brain injury (TBI) sample.

    Method: Neuropsychological measures of attention and working memory were administered to 20 participants with complicated mild-to-very severe TBI and 20 control participants. Tract-based spatial statistics was used to assess fractional anisotropy (FA) and mean diffusivity (MD) of white matter tracts for 15 TBI participants and 20 controls. Read More

    Conscious status is associated with the likelihood of trauma centre care and mortality in patients with moderate-to-severe traumatic brain injury.
    Brain Inj 2018 21;32(6):784-793. Epub 2018 Mar 21.
    a Johns Hopkins Surgery Center for Outcomes Research, Department of Surgery , Johns Hopkins School of Medicine , Baltimore , MD , USA.
    Objective: To assess the relationship between The International Classification of Diseases, Ninth Revision, Clinical Modification-derived conscious status and mortality rates in trauma centres (TC) vs. non-trauma centres (NTC).

    Methods: Patients in the 2006-2011 Nationwide Emergency Department Sample meeting, The Centers for Disease Control and Prevention criteria for traumatic brain injury (TBI), with head/neck Abbreviated Injury Scale (AIS) scores ≥3 were included. Read More

    Barriers and strategies for coordinating care among veterans with traumatic brain injury: a mixed methods study of VA polytrauma care team members.
    Brain Inj 2018 14;32(6):755-762. Epub 2018 Mar 14.
    g Center for Healthcare Organization and Implementation Research (CHOIR) , Edith Nourse Rogers Memorial Veterans Hospital , Bedford , MA , USA.
    Background: Veterans who experience traumatic brain injury (TBI) may have long-term needs placing a premium on well-coordinated care. This study aimed to (1) identify barriers to care coordination for Veterans with TBI; and (2) describe strategies used by VA polytrauma care team members to coordinate care for Veterans with TBI.

    Methods: We utilised a mixed method design, including an online survey of VA polytrauma care team members (N = 236) and subsequent semi-structured interviews (N = 25). Read More

    Autonomic cardiac control response to walking and executive cognitive task in adolescents with acquired brain injury and typically developed controls.
    Brain Inj 2018 13;32(6):770-775. Epub 2018 Mar 13.
    a Department of Physical Therapy, School of Health Professions, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel.
    Introduction: Adolescents with acquired brain injury (ABI) present a range of physical and cognitive as well as cardiac autonomic control system (CACS) dysfunctions.

    Aim: To examine the CACS response to an executive task, a physical task and a combined physical and executive task, in adolescents with ABI and typically developed (TD) controls.

    Methods: Included were two groups: The first group consisted of 17 adolescents (11-18 years) with ABI, during the in-patient or out-patient rehabilitation period. Read More

    Difficulty hearing in noise: a sequela of concussion in children.
    Brain Inj 2018 8;32(6):763-769. Epub 2018 Mar 8.
    a Auditory Neuroscience Laboratory , Northwestern University , Evanston , IL , USA.
    Objective: Concussions can result in auditory processing deficits even in the absence of hearing loss. In children and adolescents, the extent to which these impairments have functional consequences for everyday listening, such as the ability to understand speech in noisy environments, is unknown.

    Research Design: Case-control study. Read More

    Decomposition of leg movements during overground walking in individuals with traumatic brain injury.
    Brain Inj 2018 1;32(6):739-746. Epub 2018 Mar 1.
    a Department of Physical Therapy , Central Michigan University , Mt. Pleasant , MI , USA.
    Objective: Walking requires precise coordination of bilateral lower extremity motions at all joints. This ability can be affected by traumatic brain injury (TBI). The study investigated inter-joint coordination of lower extremities during overground walking after TBI. Read More

    "Five-layer gasket seal" watertight closure for reconstruction of the skull base in complex bilateral traumatic intraorbital meningoencephaloceles: a case report and literature review.
    Brain Inj 2018 27;32(6):804-807. Epub 2018 Feb 27.
    a Department of Neurosurgery , The First Hospital of China Medical University , Shenyang , China.
    Purpose: Traumatic meningoencephalocele primarily occurs as a rare but complex complication of cranial base and orbital roof fractures. Traumatic intraorbital meningoencephalocele, which is rare and easily overlooked, can be life-threatening since cephalomeningitis occurs due to cerebrospinal fluid (CSF) leakage. It is obscure for the operative indications or standard surgical methods of traumatic meningoencephaloceles since the combined intricate craniofacial and basal fractures, brain injury, and CSF leak may exist. Read More

    Delayed intracranial hemorrhage in the patient with blunt trauma on anticoagulant or antiplatelet agents: routine repeat head computed tomography is unnecessary.
    Brain Inj 2018 27;32(6):735-738. Epub 2018 Feb 27.
    a Grant Medical Center , Trauma, an OhioHealth Hospital , Columbus , OH , USA.
    Objective: We postulate that in patients with blunt trauma on anticoagulant or antiplatelet agents, incidence and complication rate of delayed intracranial hemorrhage (DICH) after an initially negative head CT is low and routine repeat head CT is not warranted.

    Design: A retrospective, observational study performed from 2008 to 2012.

    Patients: A total of 338 patients with blunt trauma with pre-admission history of any anticoagulant use, who had an initially negative head CT, followed by a repeat CT within 48 hours. Read More

    Concussion history is negatively associated with visual-motor force complexity: evidence for persistent effects on visual-motor integration.
    Brain Inj 2018 27;32(6):747-754. Epub 2018 Feb 27.
    b Kinesiology and Health Science , Utah State University , Logan , UT , USA.
    Objectives: Long-term monitoring of concussion recovery requires time- and cost-effective methods. Physiologic complexity may be useful in evaluating visual-motor integration following concussion. The purpose of this study was to quantify the extent to which prior number of concussions influenced visual-motor tracking force complexity. Read More

    Score on Coma Recovery Scale-Revised at admission predicts outcome at discharge in intensive rehabilitation after severe brain injury.
    Brain Inj 2018 26;32(6):730-734. Epub 2018 Feb 26.
    a Intensive Rehabilitation Unit, IRCCS Don Gnocchi Foundation , Florence , Italy.
    Objective: To assess the prognostic utility of the Coma Recovery Scale-Revised (CRS-R) in rehabilitation of patients surviving from severe brain injury.

    Methods: In this prospective cohort study, all patients consecutively admitted to an Italian Intensive Rehabilitation Unit, with a diagnosis of unresponsive wakefulness syndrome (UWS) or minimally conscious state (MCS) due to acquired brain injury, underwent clinical evaluations using the Italian version of the CRS-R. At discharge, patients transitioning from UWS to MCS or emergence from MCS (E-MCS) and from MCS to E-MCS were classified as improved responsiveness (IR). Read More

    Measurement properties of the Chinese version of the Mental Fatigue Scale for patients with traumatic brain injury.
    Brain Inj 2018 20;32(5):652-664. Epub 2018 Feb 20.
    a School of Nursing, College of Nursing , Taipei Medical University , Taipei , Taiwan.
    Objectives: To translate the Mental Fatigue Scale into a Chinese version (CMFS), to develop a more valid and precise CMFS by using an item response theory-based model, and to examine the reliability and validity of the CMFS.

    Methods: One hundred and fifty adults having traumatic brain injury for at least 6 months were included. Each participant completed a battery of questionnaires (i. Read More

    Post-concussive symptoms after a mild traumatic brain injury during childhood and adolescence.
    Brain Inj 2018 15;32(5):617-626. Epub 2018 Feb 15.
    b National Institute for Stroke and Applied Neurosciences , AUT University , Auckland , New Zealand.
    Objective: Mild traumatic brain injury (mTBI) is common injury during childhood and adolescence but the long-term outcomes are poorly understood. This study examined post-concussive symptoms and behavioural outcomes in children and adolescents up to 24 months post-mTBI.

    Method: Parents of children aged 8-15 years with mTBI completed the BASC-2 and Rivermead Post-Concussion Symptoms Questionnaire at baseline, 1-, 6-, 12- and 24 months post-injury. Read More

    Mild traumatic brain injury: evaluation of olfactory dysfunction and clinical-neurological characteristics.
    Brain Inj 2018 15;32(5):550-556. Epub 2018 Feb 15.
    a Department of 'Organi di Senso' , University "Sapienza" , Rome , Italy.
    Objective: To evaluate olfactory function and clinical-neurological characteristics in a group of patients with mild head trauma.

    Methods: A total of 352 patients with MTBI underwent olfactory function evaluation. The site of head trauma, loss of consciousness <20 min, memory loss, subjective presence or absence of olfaction and other clinical, neurological and radiological aspects were evaluated and compared with the olfactory dysfunction. Read More

    Chondroitinase ABC for neurological recovery after acute brain injury: systematic review and meta-analyses of preclinical studies.
    Brain Inj 2018 13;32(6):715-729. Epub 2018 Feb 13.
    b Translational Neurosurgery Unit , Centre for Clinical Brain Sciences, University of Edinburgh , Edinburgh , United Kingdom.
    Objectives: Damage to critical brain regions causes deficits in important neurological functions. Chondroitinase ABC (ChABC) has been shown to promote neuroplasticity and may ameliorate neurological deficits caused by disease or trauma. This systematic review identifies and evaluates preclinical studies of ChABC as a treatment for acute brain injury. Read More

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