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    3434 results match your criteria Brain Injury[Journal]

    1 OF 69

    'It's nothing you could ever prepare anyone for': the experiences of young people and their families following parental stroke.
    Brain Inj 2018 Jan 18:1-13. Epub 2018 Jan 18.
    a School of Life and Medical Sciences, University of Hertfordshire , Hatfield , UK.
    Aims: This study sought to explore the experiences of young people (aged 8-16) and their families following parental acquired brain injury (ABI), with the aim of developing an understanding of the ways in which members of a family make sense of events post-injury, and to consider the implications of different perspectives on adjustment and coping.

    Design: The study applied a qualitative approach using a thematic analysis methodology.

    Procedure: Individual semi-structured interviews were conducted with 10 individuals from three families affected by parental stroke. Read More

    Platelet transfusion does not improve outcomes in patients with brain injury on antiplatelet therapy.
    Brain Inj 2018 Jan 17:1-6. Epub 2018 Jan 17.
    a Center for Trauma and Critical Care, Department of Surgery , George Washington University , Washington , DC, USA.
    Introduction: Platelet dysfunction following traumatic brain injury (TBI) is associated with worse outcomes. The efficacy of platelet transfusion to reverse antiplatelet medication (APM) remains unknown. Thrombelastography platelet mapping (TEG-PM) assesses platelet function. Read More

    Unscheduled adolescents return to the emergency department following acute concussion.
    Brain Inj 2018 Jan 17:1-4. Epub 2018 Jan 17.
    d Emergency Department , Ruth Children's Hospital, Rambam Health Care Campus , Haifa , Israel.
    Objective: Emergency department (ED) visits due to concussion have increased over recent years. We aimed to identify variables associated with unscheduled adolescents return to the ED.

    Methods: A retrospective cohort study was conducted. Read More

    Anaemia worsens early functional outcome after traumatic brain injury: a preliminary study.
    Brain Inj 2018 Jan 15:1-8. Epub 2018 Jan 15.
    b Department of Pathology and Anatomical Sciences , University of Missouri School of Medicine , Columbia , MO , USA.
    Objective: To determine early effects on outcome from traumatic brain injury (TBI) induced by controlled cortical impact (CCI) associated with anaemia in mice.

    Hypothesis: Outcome from TBI with concomitant anaemia would be worse than TBI without anaemia.

    Methods: CCI was induced with electromagnetic impaction in four groups of C57BL/6J mice: sham, sham+anaemia; TBI; and TBI+anaemia. Read More

    A novel method for the rapid detection of post-translationally modified visinin-like protein 1 in rat models of brain injury.
    Brain Inj 2017 Dec 28:1-18. Epub 2017 Dec 28.
    f Sanders-Brown Center on Aging & Department of Chemistry , University of Kentucky , Lexington , KY , USA.
    Background: Although elevated serum levels of visinin-like protein 1 (VILIP-1), a neuron-specific calcium sensor protein, are associated with ischaemic stroke, only a single study has evaluated VILIP-1 as a biomarker of traumatic brain injury (TBI). The current proof-of-concept study was designed to determine whether serum VILIP-1 levels increase post-injury in a well-characterized rat unilateral cortical contusion model.

    Methods: Lateral flow devices (LFDs) rapidly (< 20 min) detected trace serum levels (pg/mL) of VILIP-1 in a small input sample volume (10 µL). Read More

    Hypopituitarism 3 and 12 months after traumatic brain injury and subarachnoid haemorrhage.
    Brain Inj 2017 Dec 28:1-8. Epub 2017 Dec 28.
    a Department of Endocrinology , Landspitali University Hospital , Reykjavik , Iceland.
    Objective: High prevalence of hypopituitarism (HP) has been reported after traumatic brain injury (TBI) and subarachnoid haemorrhage (SAH). The aim of the study was to prospectively evaluate the prevalence and progression of HP in patients after TBI and SAH in Icelandic population.

    Design: A 12 month prospective single-centre study. Read More

    The therapeutic value of cranioplasty in individuals with brain injury.
    Brain Inj 2017 Dec 28:1-7. Epub 2017 Dec 28.
    b Department of Physical Medicine and Rehabilitation New Jersey Medical School Rutgers,The State University of New Jersey , NJ , USA.
    Primary Objective: To examine the effect of cranioplasty on recovery.

    Research Design: Retrospective cohort study.

    Method And Procedures: Retrospective chart review conducted in 2011 and 2012 on adult inpatients with craniectomy who completed a continuous episode of inpatient rehabilitation before and after receiving their cranioplasty. Read More

    Virtual peer-delivered memory intervention: a single-case experimental design in an adolescent with chronic memory impairment.
    Brain Inj 2017 Dec 28:1-13. Epub 2017 Dec 28.
    d Psychology Service, Royal Childrens Hospital , Melbourne , Australia.
    Background: Children and adolescents with chronic memory impairment may develop coping strategies that enable functioning, yet these often remain undetectable using traditional psychometric measures. Personalized intervention studies that promote the use of such strategies designed specifically for use by this young cohort are scarce.

    Objective: To investigate the effect of a novel virtual reality peer-delivered memory intervention on the everyday functioning and well-being of SE, a 17-year-old female with a history of chronic verbal memory issues, impaired autobiographical event recall and elevated mood symptoms. Read More

    Procedural discourse performance in adults with severe traumatic brain injury at 3 and 6 months post injury.
    Brain Inj 2018 ;32(2):167-181
    b Discipline of Speech Pathology , The University of Sydney , Sydney , Australia.
    Background: There is limited research on communicative recovery during the early stages after a severe traumatic brain injury (TBI) in adults.

    Methods And Procedures: In the current study 43 people with severe TBI described a simple procedure at 3 and 6 months post injury and this was compared to the description provided by 37 healthy speakers. Linguistic productivity and the presence of macrostructural discourse elements were analysed. Read More

    Time since injury limits but does not prevent improvement and maintenance of gains in balance in chronic stroke.
    Brain Inj 2017 Dec 26:1-7. Epub 2017 Dec 26.
    c Rivers Lab, Department of Movement and Rehabilitation Sciences , Rutgers University-School of Professions , Newark , USA.
    Objective: To determine the influence of time since injury on the efficacy and maintenance of gains of rehabilitation of balance after stroke.

    Method: Forty-seven participants were assigned to a least (6-12 months), a moderate (12-24 months), or a most chronic (>24 months) group. Participants trained for 20 one-hour sessions, administered three to five times a week, combining conventional physical therapy and visual feedback-based exercises that trained the ankle and hip strategies. Read More

    Vegetative state outcomes improved over the last two decades.
    Brain Inj 2017 Dec 21:1-6. Epub 2017 Dec 21.
    a Loewenstein Rehabilitation Hospital , Raanana , Israel.
    Objective: To describe late outcomes in patients with prolonged unawareness, and factors affecting them.

    Design: A retrospective study of 154 patients with traumatic brain injury (TBI) and 52 with non-traumatic brain injury (NTBI), admitted for intensive care and consciousness rehabilitation (ICCR), in a vegetative state (VS) lasting over 1 month.

    Results: Survival rate (67% total) was higher than in past studies carried out at the same facility (p < 0. Read More

    Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice.
    Brain Inj 2018 11;32(2):257-268. Epub 2017 Dec 11.
    a Department of Physiology, Anatomy and Microbiology , School of Life Sciences, La Trobe University , Melbourne , VIC , Australia.
    Objectives: There is evidence that treatment with nerve growth factor (NGF) may reduce neuroinflammation and apoptosis after a traumatic brain injury (TBI). NGF is thought to exert its effects via binding to either TrkA or p75 neurotrophin receptors. This study aimed to investigate the effects of a selective TrkA agonist, gambogic amide (GA), on TBI pathology and outcomes in mice following lateral fluid percussion injury. Read More

    Hashtag #TBI: A content and network data analysis of tweets about Traumatic Brain Injury.
    Brain Inj 2018 ;32(1):49-63
    e Dean's Office, Faculty of Science, Engineering & Built Environment , Deakin University , Geelong , Australia.
    Objective: The aims of this study were to: (a) determine how Twitter is used by people with traumatic brain injury (TBI) and TBI organisations, (b) analyse the Twitter networks and content of tweets tagged with TBI-related hashtags, and (c) identify any challenges people with TBI encounter in using Twitter.

    Research Design: Mixed methods in a Twitter hashtag study.

    Methods: Mixed methods in a Twitter hashtag study. Read More

    Feasibility and effectiveness of a parenting programme for Mexican parents of children with acquired brain injury-Case report.
    Brain Inj 2018 7;32(2):276-285. Epub 2017 Dec 7.
    a Murdoch Childrens Research Institute , Melbourne, Victoria , Australia.
    Background: Acquired brain injury (ABI) during childhood typically causes behaviour problems in the child and high levels of stress in the family.

    Objectives: (1) To investigate the feasibility and effectiveness of a parenting programme to: improve behaviour and self-regulation (SR) in Mexican children with ABI, enhance parenting skills, and decrease parental stress in parents of children with ABI; (2) to explore the impact of parent SR on child.

    Methods: Case study design with four participants post-ABI, aged 7-12 years, recruited in Mexico City. Read More

    Validity of low-resolution eye-tracking to assess eye movements during a rapid number naming task: performance of the eyetribe eye tracker.
    Brain Inj 2018 6;32(2):200-208. Epub 2017 Dec 6.
    a Department of Neurology , NYU School of Medicine , New York , NY , USA.
    Objective: To evaluate the performance of the EyeTribe compared to the EyeLink for eye movement recordings during a rapid number naming test in healthy control participants.

    Background: With the increasing accessibility of portable, economical, video-based eye trackers such as the EyeTribe, there is growing interest in these devices for eye movement recordings, particularly in the domain of sports-related concussion. However, prior to implementation there is a primary need to establish the validity of these devices. Read More

    Physical activity: perceptions of people with severe traumatic brain injury living in the community.
    Brain Inj 2018 6;32(2):209-217. Epub 2017 Dec 6.
    a Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences , Monash University , Melbourne , Australia.
    Primary Objective: Increasing physical activity (PA) among people with severe traumatic brain injury (TBI) represents an important long-term rehabilitation goal. To design effective interventions to promote PA, the factors associated with PA engagement post-TBI need to be understood.

    Research Design: A qualitative study design was employed to investigate the factors influencing PA engagement in people with severe TBI living in the community. Read More

    Efficacy of an intervention programme for rehabilitation of awareness of deficit after acquired brain injury: A pilot study.
    Brain Inj 2018 5;32(2):158-166. Epub 2017 Dec 5.
    a Department of Psychology, Faculty of Health Sciences , Camilo José Cela University , Madrid , Spain.
    Background: Impaired Awareness of Deficit (AD) is a frequent symptom after suffering acquired brain injury (ABI) that severely influences patients' daily lives.

    Primary Objective: Pilot study to assess the effectiveness of a structured intervention programme which was developed from a biopsychosocial approach, and relied on common therapeutic strategies of proven effectiveness.

    Methods: We assessed the effectiveness of our intervention on a sample of 60 patients with ABI, 30 of whom received the specific AD intervention programme, while the other 30 followed an equivalent rehabilitation approach where they received no specific intervention on AD. Read More

    Survival and mortality following TBI.
    Brain Inj 2018 4;32(2):149-157. Epub 2017 Dec 4.
    a TBI Research Unit, Loewenstein Rehabilitation Hospital, Raanana, Clalit Health Services, and Sackler Faculty of Medicine , Tel-Aviv University , Israel.
    Objectives: Evaluation of life expectancy (LE) post traumatic brain injury (TBI) is important for planning services for patients and for dealing with medico-legal aspects. We hypothesized that LE for patients who survived 2 years post injury is equal to that of the general population (GP).

    Methods: A cohort of 279 patients was assembled during a 5-year period and was followed for 22-27 years. Read More

    Changes in working memory performance in youth following concussion.
    Brain Inj 2018 30;32(2):182-190. Epub 2017 Nov 30.
    e Toronto Rehab Institute , University Health Network and Occupational Science and Occupational Therapy and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada.
    Objective: The purpose of this study was to compare the working memory (WM) performance pre- and post-concussion, and investigate the relationships between performance changes and characteristics such as self-reported symptom scores, number of days post-injury and age at injury in 10-14-year-old youth.

    Methods: Twenty-one youth (17 males) aged 10-14 years recruited from the community completed verbal and non-verbal WM tasks pre- and post-concussion. Performance was measured using accuracy and performance errors (false alarms and misses). Read More

    Cognitive function and participation in children and youth with mild traumatic brain injury two years after injury.
    Brain Inj 2018 30;32(2):230-241. Epub 2017 Nov 30.
    g Department of Pediatric Neurology Erasmus MC University Medical Centre, Rotterdam , The Netherlands.
    Background: 10-20% of children and youth with mild traumatic brain injury (mTBI) suffer from long-term cognitive impairments with, supposedly, a negative impact on most domains of functioning.

    Objectives: To describe cognitive functioning and participation in children and youth two-years post-mTBI and to determine associated risk factors.

    Methods: Cross-sectional study among 73 patients (aged 6-22 years), hospital diagnosed with mTBI. Read More

    Intravenous saline administration in patients with severe acquired brain injury and orthostatic intolerance for tilt-table mobilization.
    Brain Inj 2018 30;32(2):252-256. Epub 2017 Nov 30.
    a Research Unit on Brain Injury Rehabilitation , Department of Neurorehabilitation/TBI Unit , Rigshospitalet, Copenhagen , Denmark.
    Primary Objective: This study aimed to investigate the effect of intravenous saline administration on orthostatic hypotension (OH) during head up tilt (HUT) and the change in the renin-angiotensin-aldosterone system before and after HUT in patients with severe acquired brain injury (ABI).

    Research Design: The study is designed as an observational study.

    Methods And Procedures: Fourteen patients with ABI, low level of consciousness and OH were monitored before, during and after HUT with non-invasive beat-to-beat blood pressure measurement, and transcranial Doppler determination of middle cerebral artery blood flow velocity. Read More

    When normal scores don't equate to independence: Recalibrating ratings of neurobehavioural disability from the 'St Andrew's - Swansea Neurobehavioural Outcome Scale' to reflect context-dependent support.
    Brain Inj 2018 30;32(2):218-229. Epub 2017 Nov 30.
    c Neuropsychology Clinic, College of Medicine, Swansea University , Swansea , UK.
    Primary Objective: Context is critical to the interpretation of measurement instruments that capture acquired brain injury (ABI) outcomes. Ratings reflect behaviours and abilities observed in a particular setting; it cannot be assumed that results are generalizable beyond these. This study explored the utility of a method to convey the impact of context-dependent support given on ratings of neurobehavioural disability (NBD) using the St Andrews-Swansea Neurobehavioural Outcome Scale (SASNOS). Read More

    Prevalence of depression after TBI in a prospective cohort: The SHEFBIT study.
    Brain Inj 2018 30;32(1):84-90. Epub 2017 Nov 30.
    c Institute of Work Psychology , Sheffield University Management School , Sheffield , UK.
    Objective: The objective is to measure the prevalence of depression after traumatic brain injury (TBI) and the features associated with increased risk in a cohort that reflects clinical practice.

    Methods: Prospective TBI admissions to a large Teaching Hospital Emergency Department were recruited over a 2-year period. Assessments for depression and other psychosocial and global outcomes were completed at 3 months post-injury. Read More

    A validation of the Polish version of the Coma Recovery Scale-Revised (CRSR).
    Brain Inj 2018 28;32(2):242-246. Epub 2017 Nov 28.
    a Psychophysiology Laboratory, Institute of Psychology , Jagiellonian University , Kraków , Poland.
    Primary Objective: The aim of this study was to determine the validity of the Polish version of the Coma Recovery Scale-Revised (CRS-R).

    Methods And Design: Two trained raters, A and B, administered CRS-R on a group of 20 patients with severe brain injury (median age ± SD, 38.0 ± 14. Read More

    Prevalence and association of oral candidiasis with dysphagia in individuals with acquired brain injury.
    Brain Inj 2018 28;32(2):247-251. Epub 2017 Nov 28.
    a Research Unit, Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University , Hammel , Denmark.
    Objective: To describe the prevalence of oral candidiasis (OC) in individuals with acquired brain injury (ABI) and to evaluate the association of OC with improvement in dysphagia.

    Design: Longitudinal observational study.

    Methods: Individuals with ABI admitted to rehabilitation were recruited over a one-year period (n = 206 (59% with dysphagia)). Read More

    Early changes in cerebral autoregulation among youth hospitalized after sports-related traumatic brain injury.
    Brain Inj 2018 28;32(2):269-275. Epub 2017 Nov 28.
    d Department of Anesthesiology , University of Pennsylvania , Philadelphia , PA, USA.
    Objective: To examine early cerebral haemodynamic changes among youth hospitalized with sports-related traumatic brain injury (TBI).

    Study Design: Youth 0-18 years admitted to a level one trauma centre with sports-related TBI were enrolled. Daily measures included clinical symptoms and Glasgow Coma Scale (GCS) score. Read More

    Modulation of working memory load distinguishes individuals with and without balance impairments following mild traumatic brain injury.
    Brain Inj 2018 28;32(2):191-199. Epub 2017 Nov 28.
    a Department of Physical Therapy and Rehabilitation Science , University of Maryland School of Medicine , Baltimore , MD , USA.
    Objectives: Balance and gait deficits can persist after mild traumatic brain injury (TBI), yet an understanding of the underlying neural mechanism remains limited. The purpose of this study was to investigate differences in attention network modulation in patients with and without balance impairments 2-8 weeks following mild TBI.

    Methods: Using functional magnetic resonance imaging, we compared activity and functional connectivity of cognitive brain regions of the default mode, central-executive and salience networks during a 2-back working memory task in participants with mild TBI and balance impairments (n = 7, age 47 ± 15 years) or no balance impairments (n = 7, age 47 ± 15 years). Read More

    Validation of 'reported concussion' within a national health survey.
    Brain Inj 2018 27;32(1):41-48. Epub 2017 Nov 27.
    b Perinatal Epidemiology Research Unit, Department of Pediatrics and Department of Obstetrics and Gynaecology , Dalhousie University , Halifax , NS , Canada.
    Setting: The Canadian Community Health Survey (CCHS) is a national cross-sectional health survey, which has collected information on injuries serious enough to limit normal activity.

    Objective: To assess the construct and discriminant validity of reporting 'concussion or other brain injury' in the CCHS as the respondents' most serious injury.

    Methods: Construct validity was assessed by describing the injury profile. Read More

    Temporal profile of care following mild traumatic brain injury: predictors of hospital admission, follow-up referral and six-month outcome.
    Brain Inj 2017 ;31(13-14):1820-1829
    a Department of Neurological Surgery , University of California, San Francisco , San Francisco , CA , USA.
    Objective: To investigate the clinical management and medical follow-up of patients with mild traumatic brain injury (mTBI) presenting to emergency departments (EDs).

    Methods: Overall, 168 adult patients with mTBI from the prospective, multicentre Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) Pilot study with Glasgow Coma Scale (GCS) 13-15, no polytrauma and alive at six months were included. Predictors for hospital admission, three-month follow-up referral and six-month functional disability (Glasgow Outcome Scale-Extended (GOSE) ≤ 6) were analysed using multivariable regression. Read More

    Comprehensive assessment of shockwave intensity: Transcriptomic biomarker discovery for primary blast-induced mild traumatic brain injury using the mammalian hair follicle.
    Brain Inj 2018 20;32(1):123-134. Epub 2017 Nov 20.
    a Chemistry and Chemical Engineering Department , Royal Military College of Canada , Kingston , ON , Canada.
    Objective: Primary blast-induced mild traumatic brain injury (mTBI) is an injury experienced during modern warfare due to exposure to the pressure waves produced by the detonation of explosives. With virtually no apparent physical damage or symptoms presented, there is a need for more objective and accessible mTBI biomarkers posing minimal invasiveness risk.

    Methods: We measured the transcriptomic sensitivity of the hair follicles in relation to the severity of primary blast-derived TBI. Read More

    Prognostic value of neuron-specific enolase (NSE) for prediction of post-concussion symptoms following a mild traumatic brain injury: a systematic review.
    Brain Inj 2018 20;32(1):29-40. Epub 2017 Nov 20.
    a Département de Médecine Familiale et Médecine d'Urgence, Faculté de Médecine , Université Laval , Québec , Canada.
    Background: This systematic review aimed to determine the prognostic value of neuron-specific enolase (NSE) to predict post-concussion symptoms following mild traumatic brain injury (TBI).

    Methods: Seven databases were searched for studies evaluating the association between NSE levels and post-concussion symptoms assessed ≥ 3 months (persistent) or ≥ 7 days < 3 months (early) after mild TBI. Two researchers independently screened studies for inclusion, extracted data and appraised quality using the Quality in Prognostic Studies (QUIPS) tool. Read More

    Pre-injury psychosocial and demographic predictors of long-term functional outcomes post-TBI.
    Brain Inj 2018 20;32(1):78-83. Epub 2017 Nov 20.
    b Departments of Physical Medicine and Rehabilitation and Emergency Medicine , Wayne State University School of Medicine , Detroit , MI , USA.
    Objective: To determine whether pre-injury psychosocial and demographic factors differentially influence long-term functional outcomes post-TBI.

    Setting: Urban rehabilitation hospital.

    Participants: 149 individuals, ages 16-75, who sustained a mild complicated, moderate or severe TBI, were enrolled in a TBI Model System (TBIMS), and had functional outcome data five-15 years post-injury. Read More

    Risk factors for intracranial lesions and mortality in older patients with mild traumatic brain injuries.
    Brain Inj 2018 20;32(1):99-104. Epub 2017 Nov 20.
    a Emergency Unit , Complejo Hospitalario Universitario de Granada , Granada , Spain.
    Primary Objective: To identify risk factors for intracerebral lesion (ICL) in older adults with mild traumatic brain injury (MTBI) and evaluate the influence of comorbidities on outcomes.

    Research Design: Prospective cohort study.

    Methods And Procedures: Information was gathered on clinical history/examination, cranial computed tomography, admission Glasgow Coma Scale (GCS) score, analytical and coagulation findings, and mortality at 1 week post-discharge. Read More

    Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice.
    Brain Inj 2018 20;32(1):113-122. Epub 2017 Nov 20.
    a Beth K and Stuart C. Yudofsky Division of Neuropsychiatry , Baylor College of Medicine , Houston , TX , USA.
    Primary Objective: Repeated traumatic brain injuries (rmTBI) are frequently associated with debilitating neuropsychiatric conditions such as cognitive impairment, mood disorders, and post-traumatic stress disorder. We tested the hypothesis that repeated mild traumatic brain injury impairs spatial memory and enhances anxiety-like behaviour.

    Research Design: We used a between groups design using single (smTBI) or repeated (rmTBI) controlled cranial closed skull impacts to mice, compared to a control group. Read More

    Psychological outcome after severe traumatic brain injury in adolescents and young adults: The chronic phase.
    Brain Inj 2018 20;32(1):64-71. Epub 2017 Nov 20.
    e Department of Neurology, National Study of Young Brain Injury Survivors , Rigshospitalet, Copenhagen University Hospital , Glostrup , Denmark.
    Objectives: Young individuals surviving severe traumatic brain injury (TBI) frequently experience a wide range of cognitive, emotional and behavioural consequences. This cross-sectional follow-up study investigated psychological outcome of young survivors in the chronic phase, and whether psychological outcome was associated with improvement of functional abilities during sub-acute admission.

    Methods: Patients, who acquired a severe TBI during adolescence or early adulthood (n = 36) and received early intensive rehabilitation, were contacted for follow-up assessment concerning psychological outcome and completed the Adult Self Report 18-59 (ASR18-59). Read More

    Survival and consciousness recovery are better in the minimally conscious state than in the vegetative state.
    Brain Inj 2018 20;32(1):72-77. Epub 2017 Nov 20.
    a AP-HP, Groupe hospitalier Pitié-Salpêtrière , Department of Neurology , Paris , France.
    Background: The prognosis value of early clinical diagnosis of consciousness impairment is documented by an extremely limited number of studies, whereas it may convey important information to guide medical decisions.

    Objective: We aimed at determining if patients diagnosed at an early stage (<90 days after brain injury) as being in the minimally conscious state (MCS) have a better prognosis than patients in the vegetative state/Unresponsive Wakefulness syndrome (VS/UWS), independent of care limitations or withdrawal decisions.

    Methods: Patients hospitalized in ICUs of the Pitié-Salpêtrière Hospital (Paris, France) from November 2008 to January 2011 were included and evaluated behaviourally with standardized assessment and with the Coma Recovery Scale-Revised as being either in the VS/UWS or in the MCS. Read More

    High-Definition transcranial direct current stimulation in early onset epileptic encephalopathy: a case study.
    Brain Inj 2018 20;32(1):135-143. Epub 2017 Nov 20.
    d Department of Biomedical Engineering , The City College of the City University of New York , New York , USA.
    Primary Objective: Early onset epileptic encephalopathy is characterized by high daily seizure-frequency, multifocal epileptic discharges, severe psychomotor retardation, and death at infancy. Currently, there are no effective treatments to alleviate seizure frequency and high-voltage epileptic discharges in these catastrophic epilepsy cases. The current study examined the safety and feasibility of High-Definition transcranial direct current stimulation (HD-tDCS) in reducing epileptiform activity in a 30-month-old child suffering from early onset epileptic encephalopathy. Read More

    Recovery of an injured cingulum concurrent with improvement of short-term memory in a patient with mild traumatic brain injury.
    Brain Inj 2018 15;32(1):144-146. Epub 2017 Nov 15.
    a Department of Physical Medicine and Rehabilitation, College of Medicine , Yeungnam University , Daegu , South Korea.
    Objectives: We reported on a patient with mild traumatic brain injury (TBI) who showed recovery of an injured cingulum concurrent with improvement of short-term memory, which was demonstrated on follow-up diffusion tensor tractography (DTT).

    Methods: A 55-year-old male patient suffered head trauma resulting from falling from approximately 2 m while working at a construction site. The patient showed mild memory impairment (especially short-term memory impairment) at 3 months after onset: Memory Assessment Scale (global memory: 95 (37%ile), short-term memory: 75 (5%ile), verbal memory: 80 (9%ile) and visual memory: 112 (79%ile)). Read More

    Investigating ioflupane I123 injection and single photon emission tomography as an imaging biomarker for long-term sequelae following mild traumatic brain injury.
    Brain Inj 2018 13;32(1):105-112. Epub 2017 Nov 13.
    a Department of Neurology , NorthShore University HealthSystem , Evanston , IL , USA.
    Objective: To determine whether there were differences in clinical outcomes for ioflupane I123 injection (DaTscan) and single photon emission tomography consistent with early Parkinson's disease (PD) among individuals with a history of mild traumatic brain injury (mTBI).

    Methods: We performed a case-control study among patients presenting to the Emergency Room (ER) during 2006-2013 with mTBI (cases, n = 34) or without mTBI (controls, n = 33). We performed clinical and imaging measurements in cases and controls at least 1-year post-presentation to the ER (average three years four months). Read More

    Longitudinal trajectories of post-concussive and depressive symptoms in adolescents with prolonged recovery from concussion.
    Brain Inj 2017 8;31(13-14):1736-1744. Epub 2017 Nov 8.
    a Center for Child Health, Behavior and Development , Seattle Children's Research Institute , Seattle , WA, USA.
    Primary Objective: To investigate the symptom trajectories of depressive and post-concussive symptoms (PCS) in slow-to-recover adolescents to understand how the two sets of symptoms are related.

    Research Design: We used data from a randomized clinical trial of a collaborative care intervention for post-concussive symptoms to better understand how these two sets of symptoms change in parallel over 6 months.

    Methods And Procedure: PCS and depressive symptom scores for 49 adolescents (ages 11-17) were measured at enrolment and after 1, 3, and 6 months. Read More

    Inter- and intra-tester reliability of the acute brain injury physiotherapy assessment (ABIPA) in patients with acquired brain injury.
    Brain Inj 2017 8;31(13-14):1799-1806. Epub 2017 Nov 8.
    b Australian Catholic University, (Brisbane Campus) , Brisbane , QLD , Australia.
    Background: The Acute Brain Injury Physiotherapy Assessment (ABIPA) is a new outcome measure with face validity and sensitivity to change in the early stages of neuromotor recovery after acquired brain injury (ABI). Reliability of physiotherapists using the tool has not been established.

    Objective: Determine inter- and intra-tester reliability of physiotherapists using the ABIPA. Read More

    A summary on the effectiveness of the Amsterdam memory and attention training for children (Amat-c) in children with brain injury.
    Brain Inj 2018 8;32(1):18-28. Epub 2017 Nov 8.
    a Department of Neuropsychology & Psychopharmacology , Maastricht University , Maastricht , the Netherlands.
    Objective: To summarise the current research on the effectiveness of the Amsterdam Memory and Attention Training for Children (Amat-c).

    Methods: A literature search was conducted to find articles published about the Amat-c, using PubMed, psychINFO, and PsychBITE databases. Relevant search terms included Amat-c, attention and memory, and childhood ABI. Read More

    Baseline King-Devick scores for adults are not generalizable; however, age and education influence scores.
    Brain Inj 2017 8;31(13-14):1813-1819. Epub 2017 Nov 8.
    a Division of Nursing and Health Sciences, Physical Therapy Department , Neumann University , Aston , PA , USA.
    Objective: To establish normative values for the King-Devick (K-D) test to be used as a reference for determining impairment related to concussion when individual baseline scores are lacking.

    Method: Baseline K-D scores were collected for 243 participants aged 18-86.

    Results: The mean age of subjects was 40. Read More

    Diffusion MRI findings in patients with extensive and minimal post-concussion symptoms after mTBI and healthy controls: a cross sectional study.
    Brain Inj 2018 2;32(1):91-98. Epub 2017 Nov 2.
    a Dept of Clinical Medicine , Hammel Neurorehabilitation Centre and University Research Clinic, Aarhus University , Hammel , Denmark.
    Primary Objectives: We hypothesized that the microstructure of the corpus callosum, thalamus and hippocampus, as measured with diffusion and Mean of the Kurtosis Tensor (MKT) MRI, differs between healthy subjects and patients with extensive and minimal post-concussion symptoms (PCS) and that MKT measures correlate with PCS severity and self-reported cognitive symptoms.

    Research Design: A cross-sectional study comparing patients with extensive PCS and patients with minimal PCS 2-5 months after mild traumatic brain injury (mTBI) with each other and with an external healthy control group.

    Methods And Procedures: Diffusion MRI was obtained in 25 patients with extensive PCS and in 25 patients with minimal PCS as measured by the Rivermead Post-concussion Symptoms Questionnaire. Read More

    The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis.
    Brain Inj 2018 31;32(1):1-17. Epub 2017 Oct 31.
    d Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine and Psychiatry , McKnight Brain Institute, University of Florida , Gainesville , Florida , USA.
    Traumatic brain injury (TBI) is a major health concern. The purpose of this study is to identify the diagnostic accuracy of ubiquitin C-terminal hydrolase-L1 (UCH-L1)-a protein biomarker-in comparison with CT-scan findings post-TBI. Accordingly, we conducted a systematic review of eligible studies and assessed the risk of bias according to the QUADAS-2 checklist. Read More

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