3,701 results match your criteria Brain Injury[Journal]


NFL blood levels are moderated by subconcussive impacts in a cohort of college football players.

Brain Inj 2019 11;33(4):456-462. Epub 2019 Jan 11.

d Department of Neuroscience , Lewis Katz School of Medicine at Temple University , Philadelphia , PA , USA.

Introduction: Repetitive subconcussive head impacts in contact/collision sports such as in US football are believed to contribute to long-term brain changes and chronic symptoms. However, the lack of tools to measure the effects of repeated subconcussion limits our understanding of potential contributions to neuropathological alterations including cellular damage.

Methods: We examined subconcussive head impacts using an accelerometer-embedded mouthguard on changes in blood levels of neurofilament light (NFL) chain in 18 Division I college football players. Read More

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http://dx.doi.org/10.1080/02699052.2019.1565895DOI Listing
January 2019

Autonomic impairment of patients in coma with different Glasgow coma score assessed with heart rate variability.

Brain Inj 2019 12;33(4):496-516. Epub 2019 Feb 12.

g Institute of Basic and Preclinical Sciences, "Victoria de Girón" , Havana , Cuba.

Primary Objective: The objective of this study is to assess the functional state of the autonomic nervous system in healthy individuals and in individuals in coma using measures of heart rate variability (HRV) and to evaluate its efficiency in predicting mortality.

Design And Methods: Retrospective group comparison study of patients in coma classified into two subgroups, according to their Glasgow coma score, with a healthy control group. HRV indices were calculated from 7 min of artefact-free electrocardiograms using the Hilbert-Huang method in the spectral range 0. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553312DOI Listing
February 2019

Safety and feasibility of minocycline in treatment of acute traumatic brain injury.

Brain Inj 2019 Feb 12:1-11. Epub 2019 Feb 12.

a Department of Physical Medicine and Rehabilitation-Oakwood, School of Medicine , Wayne State University , Taylor , MI , USA.

Background: Minocycline is a pleomorphic neuroprotective agent well studied in animal models of traumatic brain injury (TBI) and brain ischemia.

Methods: To test the hypothesis that administration of minocycline in moderate to severe TBI (Glasgow Coma Score 3-12). Fifteen patients were enrolled in a two-dose escalation study of minocycline to evaluate the safety of twice the recommended antibiotic dosage; tier 1 n = 7 at a loading dose of 800 mg followed by 200 mg twice a day (BID) for 7 days; tier 2 n = 8 at a loading dose of 800 mg followed by 400 mg BID for 7 days. Read More

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http://dx.doi.org/10.1080/02699052.2019.1566968DOI Listing
February 2019

An examination of financial capacity and neuropsychological performance in chronic acquired brain injury (CABI).

Brain Inj 2019 Feb 3:1-12. Epub 2019 Feb 3.

c Psychology Department , Drexel University , Philadelphia , Pennsylvania , USA.

Primary Objective: Financial Capacity (FC) is known to be impaired in the acute and subacute stages of brain injury. The current study sought to examine FC in the context of chronic, moderate to severe acquired brain injury (CABI).

Research Design: The Financial Competence Assessment Inventory (FCAI), developed in Australia, was adapted to examine the integrity of FC in an American sample. Read More

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http://dx.doi.org/10.1080/02699052.2019.1570340DOI Listing
February 2019

Exploratory study of sport-related concussion effects on peripheral micro-RNA expression.

Brain Inj 2019 31;33(4):1-7. Epub 2019 Jan 31.

d Department of Community Health and Family Medicine , University of Florida , Gainesville , FL , USA.

Objective: Explore changes in micro-RNA (miRNA) expression in blood after sport-related concussion (SRC) in collegiate athletes.

Methods: Twenty-seven collegiate athletes (~41% male, ~75% white, age 18.8 ± 0. Read More

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http://dx.doi.org/10.1080/02699052.2019.1573379DOI Listing
January 2019
1 Read

Collegiate student-athlete sex, years of sport eligibility completed, and sport contact level influence on concussion reporting intentions and behaviours.

Brain Inj 2019 Jan 31:1-6. Epub 2019 Jan 31.

a Department of Kinesiology, Concussion Research Laboratory , University of Georgia , Athens , GA , USA.

Primary Objective: The objective of this study was to determine whether sex, years of sport eligibility completed, and sport contact level influenced student-athletes' concussion reporting intentions and behaviours.

Research Design: Cross-sectional.

Methods And Procedures: Student-athletes (n = 828) reported their sex, years of sport eligibility completed, sport, and completed concussion reporting intentions and behaviours surveys. Read More

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http://dx.doi.org/10.1080/02699052.2019.1568573DOI Listing
January 2019
1 Read

Vocabulary skills of school-age children with acquired brain injury: an exploration of tiered word knowledge and naming errors.

Brain Inj 2019 Jan 31:1-13. Epub 2019 Jan 31.

a Discipline of Speech Pathology, Faculty of Health Sciences , University of Sydney , Lidcombe , Australia.

Background: Vocabulary deficits are the most frequently documented communication difficulty following childhood acquired brain injury (ABI). Given the adverse consequences of limited vocabulary on academic success, it is critical to identify the presence and nature of vocabulary impairments to provide effective intervention for children with ABI.

Method: Eleven children (7;6-11;11) with moderate/severe ABI (>12 months post-injury) and individually matched typically developing (TD) controls completed an Australian adaptation of a vocabulary assessment based on a three-tiered framework: tier 1 (basic words), tier 2 (high-frequency, cross-curricular words), and tier 3 (curriculum-based words). Read More

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http://dx.doi.org/10.1080/02699052.2019.1567939DOI Listing
January 2019

Long-term factor structure of the Rivermead Post-Concussion Symptom Questionnaire in mild traumatic brain injury and normative sample.

Brain Inj 2019 Jan 30:1-5. Epub 2019 Jan 30.

b National Institute for Stroke and Applied Neuroscience, School of Public health & Psychosocial Studies , Auckland University of Technology , Auckland , New Zealand.

Background: Previous studies of the Rivermead Post-Concussive Questionnaire(RPQ)'s factor structure were conducted within 1 year post-injury. Post-concussive symptoms may persist, and are common in the general population, so determining if the factor structure in mild-TBI and controls differ is important. This study examined factor structure of the RPQ in adults 4 years post-mild-TBI and in age-/gender-matched controls. Read More

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http://dx.doi.org/10.1080/02699052.2019.1570339DOI Listing
January 2019
1 Read

Opioids and cerebral physiology in the acute management of traumatic brain injury: a systematic review.

Brain Inj 2019 Jan 29:1-8. Epub 2019 Jan 29.

a Parkwood Institute Research , Lawson Health Research Institute,Parkwood Institute , London , Ontario , Canada.

Background: Following traumatic brain injury (TBI), optimization of cerebral physiology is recommended to promote more favourable patient outcomes. Accompanying pain and agitation are commonly treated with sedative and analgesic agents, such as opioids. However, the impact of opioids on certain aspects of cerebral physiology is not well established. Read More

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http://dx.doi.org/10.1080/02699052.2019.1574328DOI Listing
January 2019

Agitated behavior scale in pediatric traumatic brain injury.

Brain Inj 2019 Jan 29:1-6. Epub 2019 Jan 29.

f Department of Critical Care Medicine , Hospital for Sick Children , Toronto , ON , Canada.

Agitation following TBI commonly occurs during the acute recovery phase. The ABS is a valid measure of agitation in adults following TBI. The objective of the study was to determine if ABS scores accurately measure acute agitation in pediatric patients recovering from TBI. Read More

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http://dx.doi.org/10.1080/02699052.2019.1565893DOI Listing
January 2019

Overview of pharmacological interventions after traumatic brain injuries: impact on selected outcomes.

Brain Inj 2019 29;33(4):442-455. Epub 2019 Jan 29.

l Department of Physical Medicine and Rehabilitation , University of Colorado Anschutz Medical Campus , Aurora , Colorado , USA.

The purpose of this study was to conduct an overview of systematic reviews (SRs) to appraise the published evidence related to pharmacological interventions after traumatic brain injury (TBI). Searches were conducted with Medline, Embase, PsycINFO, Web of Science, PubMed. 780 retrieved SRs underwent a two-level screening to determine inclusion. Read More

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http://dx.doi.org/10.1080/02699052.2019.1565896DOI Listing
January 2019
1.861 Impact Factor

Screening questionnaires for substance abuse post brain injury: a review.

Brain Inj 2019 Jan 26:1-8. Epub 2019 Jan 26.

a Lawson Health Research Institute , London , ON , Canada.

Objective: To assess the psychometric properties of the available assessment questionnaires for substance abuse studied within a brain injury population.

Methods: A literature search was conducted on MEDLINE, PsycINFO, CINAHL, and Embase databases. Articles published in English from inception through March 2018 on the screening questionnaires used to identify substance abuse post brain injury were reviewed. Read More

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http://dx.doi.org/10.1080/02699052.2019.1567938DOI Listing
January 2019

Self-awareness following a traumatic brain injury in childhood: a developmental perspective.

Brain Inj 2019 Jan 25:1-10. Epub 2019 Jan 25.

b University of Warwick , Coventry.

Impaired self-awareness is a common consequence following a brain injury that affects engagement in rehabilitation and results in poor long term functional outcomes. Literature regarding self-awareness following a brain injury in childhood is lacking. The aim of this research study was to understand the self-awareness of deficits from a developmental perspective. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1566838DOI Listing
January 2019
1 Read

Development of the family needs questionnaire - pediatric version [FNQ-P] - phase I.

Brain Inj 2019 Jan 24:1-10. Epub 2019 Jan 24.

a Bloorview Research Institute , Toronto , Ontario , Canada.

Objective: To adapt the well-validated 37-item adult Family Needs Questionnaire to make it suitable for families of children and youth with acquired brain injury (ABI).

Methods: Measurement construction employed a modified Delphi technique to identify the most relevant content items for the pediatric Family Needs Questionnaire (FNQ-P). The Delphi process involved a panel of 11 ABI-team clinicians and seven family caregivers of children/youth with an ABI and four rounds of anonymous voting on each item's importance. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1566836DOI Listing
January 2019
4 Reads

Care coordination experiences of people with traumatic brain injury and their family members in the 4-years after injury: a qualitative analysis.

Brain Inj 2019 Jan 23:1-10. Epub 2019 Jan 23.

a Department of Epidemiology and Preventive Medicine , Monash University , Melbourne , Australia.

Title: Care coordination experiences of people with traumatic brain injury and their family members 4-years after injury: A qualitative analysis.

Aim: To explore experiences of care coordination in the first 4-years after severe traumatic brain injury (TBI).

Methods: A qualitative study nested within a population-based longitudinal cohort study. Read More

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http://dx.doi.org/10.1080/02699052.2019.1566835DOI Listing
January 2019
1 Read

The long-term effects of childhood traumatic brain injury on adulthood relationship quality.

Brain Inj 2019 Jan 21:1-8. Epub 2019 Jan 21.

b School of Psychological Sciences , University of Melbourne , Melbourne , Australia.

Primary Objective: To investigated the long-term effect of childhood Traumatic Brain Injury (TBI) on adulthood Relationship Quality (RQ), examining injury severity, age of injury, and markers of prefrontal cortex (PFC) functioning, apathy, disinhibition, and executive dysfunction.

Research Design: Longitudinal, between-subjects, cross-sectional design using retrospective and current data.

Methods And Procedures: Participants (N = 169; 61 mild TBI (mTBI); 65 moderate to severe TBI (MSTBI); 43 orthopaedic injury (OI); Injury age: 1-17 years; Testing age: 18-31 years) completed a structured interview regarding their injury, demographic characteristics and RQ, the National Adults Reading Test, and Frontal Systems Behaviour Scale. Read More

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http://dx.doi.org/10.1080/02699052.2019.1567936DOI Listing
January 2019
1 Read

Prediction of discharge destination after traumatic brain injury in children using the head abbreviated injury scale.

Brain Inj 2019 Jan 19:1-6. Epub 2019 Jan 19.

a Department of Neurosurgery , University of Minnesota , Minneapolis , Minnesota , USA.

Introduction: Traumatic brain injury (TBI) is a major public health problem, particularly in children. Prognostication of injury severity at the time of presentation is difficult. The Abbreviated Injury Scale (AIS) is a commonly used anatomical-based coding system created to classify and describe injury severity after initial presentation, once test results are able to better define the anatomical characteristics of the injury. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1566966DOI Listing
January 2019
4 Reads

Physiological and pathological covariates of persistent concussion-related fatigue: results from two regression methodologies.

Brain Inj 2019 20;33(4):463-479. Epub 2019 Jan 20.

a Rehabilitation Sciences Institute, Faculty of Medicine , University of Toronto , Canada , Ontario , Canada.

Background: Fatigue severity in persons with mild traumatic brain injury (mTBI) has received little research attention, despite its typically positively skewed nature. Investigation of covariates across a range of fatigue severity may provide insight into important contributors.

Objective: To assess the relative significance of a priori-hypothesized covariates of physiological and pathological (mental and physical) fatigue in persons with mTBI/concussion, applying ordinary least squares (OLS) and quantile regression (QR) approaches. Read More

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http://dx.doi.org/10.1080/02699052.2019.1566833DOI Listing
January 2019
2 Reads

Validation of the Chinese version of the Coma Recovery Scale-Revised (CRS-R).

Brain Inj 2019 19;33(4):529-533. Epub 2019 Jan 19.

a International Vegetative State and Consciousness Science Institute, Hangzhou Normal University , Hangzhou , Zhejiang , China.

Primary Objective: This study aims to validate the Chinese version of the Coma Recovery Scale-Revised (CRS-R).

Methods: One hundred sixty-nine patients were assessed with both the CRS-R and the Glasgow Coma Scale (GCS), diagnosed as being in unresponsive wakefulness syndrome (UWS, formerly known as vegetative state), minimally conscious state (MCS), or emergence from MCS (EMCS). A subgroup of 50 patients has been assessed twice by the same rater, within 24 h. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1566832DOI Listing
January 2019
6 Reads

Impaired ankle joint mechanics during running can be resolved in people with traumatic brain injury.

Brain Inj 2019 Jan 20:1-9. Epub 2019 Jan 20.

c La Trobe Sport and Exercise Medicine Research Centre , La Trobe University , Bundoora , Victoria , Australia.

Objectives: 1) To compare lower-limb joint mechanics during running for people with traumatic brain injury (TBI) to equivalent data obtained from a group of healthy controls (HCs); and 2) To determine if deficits identified in biomechanical variables during running for people with TBI responded to a six-month period of rehabilitation.

Methods: Running biomechanics data were recorded from 12 people with TBI who were attending a large metropolitan rehabilitation hospital for mobility limitations, and a comparative sample of 10 HCs at baseline and six-month follow-up.

Main Measures: Average power absorbed and generated at the hip, knee and ankle joints during stance. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1567940DOI Listing
January 2019
4 Reads

Predictive utility of an adapted Marshall head CT classification scheme after traumatic brain injury.

Brain Inj 2019 Jan 19:1-8. Epub 2019 Jan 19.

i Department of Physical Medicine and Rehabilitation , Spaulding Rehabilitation Hospital , Charlestown , Massachusetts , USA.

Objective: To study the predictive relationship among persons with traumatic brain injury (TBI) between an objective indicator of injury severity (the adapted Marshall computed tomography [CT] classification scheme) and clinical indicators of injury severity in the acute phase, functional outcomes at inpatient rehabilitation discharge, and functional and participation outcomes at 1 year after injury, including death.

Participants: The sample involved 4895 individuals who received inpatient rehabilitation following acute hospitalization for TBI and were enrolled in the Traumatic Brain Injury Model Systems National Database between 1989 and 2014.

Design: Head CT variables for each person were fit into adapted Marshall CT classification categories I through IV. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1566970DOI Listing
January 2019
3 Reads

Psychometric evaluation of the Self-Awareness in Daily Life-3 Scale (SADL-3) for the assessment of self-awareness after acquired brain injury.

Brain Inj 2019 Jan 19:1-12. Epub 2019 Jan 19.

b Limburg Brain Injury Center , Maastricht University , Maastricht , The Netherlands.

Objective: The Self-Awareness in Daily Life-3 Scale (SADL-3) was designed to assess self-awareness in the chronic phase after acquired brain injury (ABI). The main objective was to evaluate its feasibility and usability for clinical practice, reliability and validity.

Methods: Participants were 89 patients with ABI. Read More

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http://dx.doi.org/10.1080/02699052.2019.1566969DOI Listing
January 2019
1 Read

Comparison of early and late depression after TBI; (the SHEFBIT study).

Brain Inj 2019 Jan 19:1-8. Epub 2019 Jan 19.

c Institute of Work Psychology , Sheffield University Management School , Sheffield , UK.

Objective: Evaluate the prevalence and risk factors for depression at 1 year after traumatic brain injury (TBI) and contrast against those at 10 weeks.

Methods: Prospective TBI admissions over 2 years to an emergency department were recruited to form a representative TBI population. Depression was recorded at 10 weeks and 1 year by HADS (Hospital Anxiety and Depression Scale) with score>8. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1566837DOI Listing
January 2019
9 Reads

Experiences of challenges and support among family members of people with acquired brain injury: a qualitative study in the UK.

Brain Inj 2019 19;33(4):401-411. Epub 2019 Jan 19.

a Head First , Kent , UK.

Primary Objective: Family members (FM) are affected by the impact of an Acquired Brain Injury (ABI) upon their relatives and play an important role in rehabilitation and long-term support. This study explores how families are affected and integrates their views on the formal/informal support received as a consequence of ABI.

Research Design: A qualitative research design was employed to capture the lived experience of FM of people with ABI. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1566967DOI Listing
January 2019
6 Reads

International survey on diagnostic and prognostic procedures in pediatric disorders of consciousness.

Brain Inj 2019 19;33(4):517-528. Epub 2019 Jan 19.

h DOC Research Laboratory and Neurorehabilitation Unit for DOC patients , Maugeri Clinical Scientific Institutes, IRCCS , Telese Terme , Italy.

Aims: 1. to investigate diagnostic and prognostic procedures routinely used by international professionals to assess children with disorders of consciousness (DoC); 2. to explore use and availability of internal and national guidelines for pediatric DoC; 3. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1565899DOI Listing
January 2019
6 Reads

Sex-dependent and chronic alterations in behavior and mitochondrial function in a rat model of pediatric mild traumatic brain injury.

Brain Inj 2019 19;33(4):534-542. Epub 2019 Jan 19.

b Alberta Children's Hospital Research Institute , University of Calgary , Calgary , Alberta , Canada.

Objective: To determine if chronic changes in mitochondrial function occur following a mild traumatic brain injury in young rats.

Research Design: Closed-head, weight drop model was used to cause mTBI by applying rotational forces to the brain without surgery. Behavioral battery was used to assess multiple dimensions of impairment across time. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2019.1
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http://dx.doi.org/10.1080/02699052.2019.1565898DOI Listing
January 2019
6 Reads

The effect of impact location on brain strain.

Brain Inj 2019 19;33(4):427-434. Epub 2019 Jan 19.

a Department of Mechanical Engineering , Technological University Dublin , Tallaght, Dublin , Ireland.

Objective: To determine the effect of impact direction on strains within the brain.

Research Design: Laboratory drop tests of hybrid III head-form and finite element simulation of impacts.

Methods And Procedures: A head-form instrumented with accelerometers and gyroscopes was dropped from 10 different heights in four orientations: front, rear, left and right-hand side. Read More

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http://dx.doi.org/10.1080/02699052.2019.1566834DOI Listing
January 2019
2 Reads

Balance in chronic traumatic brain injury: correlations between clinical measures and a self-report measure.

Brain Inj 2019 14;33(4):435-441. Epub 2019 Jan 14.

b Research Department , Craig Hospital , Englewood , CO , USA.

Objective: To assess associations among commonly used self-report and clinical measures of balance in chronic TBI.

Design: Cross-sectional analysis of balance in a convenience sample of individuals at least one year post TBI.

Main Outcome Measures: Activities-Specific Balance Confidence Scale (ABC) (self-reported balance impairment), Community Balance and Mobility Scale (CB&M) (clinical measure validated in TBI), and Balance Evaluation Systems Test (BESTest) (clinical measure not validated in TBI). Read More

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http://dx.doi.org/10.1080/02699052.2019.1565900DOI Listing
January 2019
1 Read

Bilateral M1 anodal transcranial direct current stimulation in post traumatic chronic minimally conscious state: a pilot EEG-tDCS study.

Brain Inj 2019 11;33(4):490-495. Epub 2019 Jan 11.

a Neuroscience and Rehabilitation Department , Ferrara University Hospital , Ferrara , Italy.

Objective: We tested the preliminary effects of bilateral anodal transcranial direct current stimulation (tDCS) in patients with disorders of consciousness.

Design: Open label pilot study.

Subjects: Ten chronic (greater than 12 months) patients in a minimally conscious state (MCS) following severe traumatic brain injury. Read More

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http://dx.doi.org/10.1080/02699052.2019.1565894DOI Listing
January 2019
1 Read

Predictors of post-concussion symptom severity in a university-based concussion clinic.

Brain Inj 2019 9;33(4):480-489. Epub 2019 Jan 9.

c Department of Community Health and Family Medicine , University of Florida , Gainesville , FL , USA.

Objective: To investigate potential predictors of acute post-concussion symptom severity in a university population.

Methods: Data were obtained from the University of Florida Student Health Care Center Concussion Databank. Symptom severity, measured by the Sport Concussion Assessment Tool - third edition Symptom Evaluation (S3SE), was analyzed at 0-3 (n = 99) and 7-14 days (n = 56) post-concussion. Read More

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http://dx.doi.org/10.1080/02699052.2019.1565897DOI Listing
January 2019
2 Reads

Traumatic brain injury in patients screened for blood alcohol concentration based on the mechanism of injury.

Brain Inj 2019 5;33(4):419-426. Epub 2019 Jan 5.

f Department of Surgery, Trauma Surgery , Hamad General Hospital , Doha , Qatar.

Introduction: We aimed to investigate in-hospital outcomes of traumatic brain injury (TBI) based on blood alcohol concentration (BAC) and mechanism of injury (MOI).

Methods: We conducted a retrospective study for patients admitted with TBI between 2010 and 2014. Based on BAC, patients were classified into [negative (-BAC) and positive (+BAC) group]. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553065DOI Listing
January 2019
4 Reads
1.861 Impact Factor

The relation between cognitive dysfunction and diffusion tensor imaging parameters in traumatic brain injury.

Brain Inj 2019 19;33(3):355-363. Epub 2018 Dec 19.

c Department of Radiology , Wayne State University School of Medicine , Detroit , MI , USA.

Purpose Of The Study: To investigate the association among global and regional white matter fractional anisotropy (FA) values following traumatic brain injury (TBI) and cognitive functioning.

Materials And Methods: This research was conducted in an urban rehabilitation hospital. Participants included adults who were healthy controls (n = 18) or who had a TBI (n = 27). Read More

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http://dx.doi.org/10.1080/02699052.2018.1553073DOI Listing
December 2018
1 Read
1.861 Impact Factor

Targeting mast cell as a neuroprotective strategy.

Brain Inj 2018 Dec 17:1-11. Epub 2018 Dec 17.

a Department of Basic Sciences, Division of Physiology , Loma Linda University School of Medicine , Loma Linda , CA , USA.

Background: Mast cells (MCs) are perivascularly located immune cells of haematopoietic origin. Emerging evidences suggest that the activation of MCs play important roles in the pathogenesis of blood brain barrier disruption, neuroinflammation, and neurodegeneration.

Objectives: In this review, we aimed to discuss the detrimental effects of MCs in response to various types of brain injury, as well as the therapeutic potential and neuroprotective effects of targeting the activation and degranulation of MCs, particularly in the management of the acute phase. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2018.1
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http://dx.doi.org/10.1080/02699052.2018.1556807DOI Listing
December 2018
11 Reads

Physiotherapy practice patterns in gait rehabilitation for adults with acquired brain injury.

Brain Inj 2019 12;33(3):333-348. Epub 2018 Dec 12.

a Department of Physical Therapy , University of Toronto , Toronto , Canada.

Objective: Gait dysfunction is common following acquired brain injury (ABI). Clinical practice guidelines can improve patient outcomes; however, information regarding ABI-specific management of gait dysfunction is limited. This study aimed to describe practice patterns of Canadian physiotherapists regarding gait rehabilitation in adults post-ABI. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553067DOI Listing
December 2018
4 Reads

Facial emotion recognition of older adults with traumatic brain injury.

Brain Inj 2019 9;33(3):322-332. Epub 2018 Dec 9.

b Department of Communication Sciences and Disorders , University of Wisconsin-Madison , Madison , WI , USA.

Objectives: The objective of this study was to examine the effects of traumatic brain injury (TBI) and age on facial emotion recognition abilities in adults. Age and TBI were expected to have negative effects on emotion recognition and a TBI by age interaction was hypothesized such that older adults with TBI would have the lowest emotion recognition scores.

Methods: A prospective cohort study was conducted. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553066DOI Listing
December 2018
1 Read

Suspiciously slow: timed digit span as an embedded performance validity measure in a sample of veterans with mTBI.

Brain Inj 2019 8;33(3):377-382. Epub 2018 Dec 8.

e Department of Neuropsychology , University of Michigan Health System , Ann Arbor , USA.

Objective: To explore the utility of Timed Digit Span (TDS) as an embedded performance validity test (PVT) in a sample of veterans with mild traumatic brain injury (mTBI). We hypothesize that TDS will predict PVT failure on an established stand-alone measure (Trial 1 of the Test of Memory Malingering; TOMM).

Methods: TDS was compared to Digit Span accuracy (DS), using TOMM as a criterion measure, in a sample of 99 veterans with mTBI. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553311DOI Listing
December 2018
2 Reads

EEG of patients in coma after traumatic brain injury reflects physical parameters of auditory stimulation but not its emotional content.

Brain Inj 2019 6;33(3):370-376. Epub 2018 Dec 6.

a Human Higher Nervous Activity Lab Moscow , Institute of Higher Nervous Activity and Neurophysiology of RAS , Moscow , Russia.

Primary Objective: We aimed to investigate the origin of EEG response of patients in coma and after moderate TBI to emotional stimulation, whether they distinguish emotional content or only react to the physical features of an audio signal.

Research Design: We registered EEG during continuous pleasant and unpleasant non-verbal stimulation and in rest. A total of 69 subjects participated in our study: healthy adults, conscious patients after moderate TBI and patients in coma after severe TBI. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553310DOI Listing
December 2018
3 Reads

Response to letter to the editor: The effects of amantadine on traumatic brain injury outcome: a double-blind, randomized, controlled, clinical trial.

Brain Inj 2019 3;33(3):399-400. Epub 2018 Dec 3.

a Department of Neurosurgery , Iran University of Medical Sciences , Tehran , Iran.

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http://dx.doi.org/10.1080/02699052.2018.1553072DOI Listing
December 2018
4 Reads
1.861 Impact Factor

Metal chaperones: a novel therapeutic strategy for brain injury?

Brain Inj 2019 3;33(3):305-312. Epub 2018 Dec 3.

a The Florey Institute of Neuroscience and Mental Health, Dementia Theme , Parkville, Victoria , Australia.

Objective: This study sought to assess the potential efficacy of a novel class of metal chaperone on the outcomes in an animal model of a controlled cortical impact. This work was predicated on previous observations that this class of compound has exhibited neuroprotective potential in other models of aging and neurodegeneration.

Research Design: The study employed a controlled cortical impact traumatic brain injury in three month old mice with subsequent behavioral and cellular assessments to determine therapeutic efficacy. Read More

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http://dx.doi.org/10.1080/02699052.2018.1552988DOI Listing
December 2018
2 Reads

The King-Devick test in mixed martial arts: the immediate consequences of knock-outs, technical knock-outs, and chokes on brain functions.

Brain Inj 2019 3;33(3):349-354. Epub 2018 Dec 3.

e Department of Neurology, and Health Science Research , Mayo Clinic , Rochester , MN , USA.

The aim of this prospective cohort study was to determine the effect of an 'event,' defined as a knock-out (KO), technical knock-out (TKO), choke, or submission, on King-Devick (K-D) test times in mixed martial arts (MMA) athletes. MMA athletes (28.3 ± 6. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553068DOI Listing
December 2018
3 Reads

Risk factors for inpatient violence and self-harm in forensic psychiatry: the role of head injury, schizophrenia and substance misuse.

Brain Inj 2019 3;33(3):313-321. Epub 2018 Dec 3.

a Clinical Psychology , University of Edinburgh , Edinburgh , UK.

Objective: To investigate factors relevant to violence and self-harm in forensic psychiatric inpatients the cross-sectional association between four potential contributory factors; head injury, schizophrenia, drug and alcohol misuse, and self-harm or violence-related outcomes was examined.

Methodology: Data were extracted from an existing dataset of routinely collected data on all patients under the care of Scotland's Forensic Mental Health Managed Care Network, of whom (n = 432) met inclusion criteria. A Factorial MANOVA and Pearson's chi-square tests were conducted to assess the relationship between potential contributory factors and self-harm and violence. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553064DOI Listing
December 2018
5 Reads

Evaluating task-based brain network activity in pediatric subjects with an mTBI: mechanisms of functional compensation are symptom-level dependent.

Brain Inj 2019 3;33(3):383-393. Epub 2018 Dec 3.

a Cognitive Neurosciences Unit , McGill University , Montreal , Canada.

The diagnosis of a mild traumatic brain injury (mTBI) places large emphasis on patient-reported symptoms which has restricted our ability to evaluate patients. Task-based functional magnetic resonance imaging has the potential to act as an objective measurement of abnormal brain activity and inform clinical decision-making; however, there is little research evaluating pediatric subjects as a function of mTBI-related symptoms. The objective of this study was to evaluate the extent to which brain activity during a spatial navigation task is different between children with mTBI and a group of healthy controls (HCs) based on symptom reporting. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2018.1
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http://dx.doi.org/10.1080/02699052.2018.1552023DOI Listing
December 2018
4 Reads

Review of 'Modulation of working memory load distinguishes individuals with and without balance impairments following mild traumatic brain injury'.

Brain Inj 2019 2;33(3):394-395. Epub 2018 Dec 2.

b Department of Health and Exercise Science , Colorado State University , Fort Collins , CO , USA.

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http://dx.doi.org/10.1080/02699052.2018.1553069DOI Listing
December 2018
3 Reads

Looking toward predicting functional recovery in disorders of consciousness: can sensorimotor integration help us?

Brain Inj 2019 2;33(3):364-369. Epub 2018 Dec 2.

a Behavioral and Robotic Neurorehabilitation Laboratory , IRCCS Centro Neurolesi "Bonino-Pulejo" , Messina , Italy.

Primary Objective: Only a few objective prognostic markers are available for patients with disorders of consciousness (DoC). We assessed whether the magnitude of short-latency afferent inhibition (SAI) might be a useful predictor of responsiveness recovery and functional outcome in patients with DoC.

Research Design: We enrolled 40 patients with prolonged Minimally Conscious State (MCS) and Unresponsive Wakefulness Syndrome (UWS) in a longitudinal, observational study. Read More

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http://dx.doi.org/10.1080/02699052.2018.1553309DOI Listing
December 2018
4 Reads

Traumatic brain injury is highly associated with self-reported childhood trauma within a juvenile offender cohort.

Brain Inj 2019 2;33(4):412-418. Epub 2018 Dec 2.

f Kirby Institute , University of New South Wales , Sydney , Australia.

Primary Objective: To identify correlates of past traumatic brain injury (TBI) in a population of young offenders.

Research Design: Cross-sectional analyses were conducted on available data from a sample derived from the NSW Young People on Community Orders Health Survey.

Procedures: Study participants were administered questionnaires to collect history relating to past TBI, childhood trauma, substance abuse, and psychological/psychiatric symptoms and underwent assessments of intellectual functioning. Read More

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http://dx.doi.org/10.1080/02699052.2018.1552020DOI Listing
December 2018
3 Reads

Reference values for the Balance Error Scoring System as measured by the Tekscan MobileMat™ in a physically active population.

Brain Inj 2019 2;33(3):299-304. Epub 2018 Dec 2.

a John A. Feagin Jr. Sports Medicine Fellowship, Department of Orthopaedic Surgery , Keller Army Community Hospital , West Point , NY , USA.

Objectives: The Balance Error Scoring System (BESS) is commonly used to measure postural stability; however, it has demonstrated inconsistent reliability values when administered by humans. The Tekscan MobileMat™ was developed to automate the assessment of BESS errors and eliminate rater subjectivity. The objective of this study was to report reference values for the BESS, as measured by the MobileMat™, and examine the effect of sex, concussion history, and competitive sport level on BESS performance. Read More

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http://dx.doi.org/10.1080/02699052.2018.1552021DOI Listing
December 2018
2 Reads

Response to letter to the editor.

Authors:
Kelly P Westlake

Brain Inj 2019 5;33(3):396. Epub 2018 Dec 5.

a Department of Physical Therapy & Rehabilitation Science , University of Maryland School of Medicine , Baltimore , MD.

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http://dx.doi.org/10.1080/02699052.2018.1553071DOI Listing
December 2018
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Clinical trial on the effects of amantadine on traumatic brain injury outcome. Is there more than meets the eye?

Authors:
Tze Chao Wee

Brain Inj 2019 5;33(3):397-398. Epub 2018 Dec 5.

a Department of Rehabilitation Medicine , Changi General Hospital , Singapore ,

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http://dx.doi.org/10.1080/02699052.2018.1553070DOI Listing
December 2018
1 Read

Family and TBI: an investigation using the Family Outcome Measure - FOM-40.

Brain Inj 2019 4;33(3):282-290. Epub 2018 Dec 4.

c Brain Injury Rehabilitation Research Group, Ingham Institute of Applied Medical Research , Sydney , Australia.

Introduction: The Family Outcome Measure (FOM-40) captures multidimensional data about well-being and capacity of family member as well as the relative with brain injury. This study aimed to produce a profile (positive and negative) of families supporting relatives with traumatic brain injury (TBI) and high support needs.

Methods: Thirty-eight dyads (family member plus relative with TBI and high daily support needs) participated in this cross-sectional survey-based pilot study. Read More

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https://www.tandfonline.com/doi/full/10.1080/02699052.2018.1
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http://dx.doi.org/10.1080/02699052.2018.1553307DOI Listing
December 2018
2 Reads

Specialized interdisciplinary rehabilitation reduces persistent post-concussive symptoms: a randomized clinical trial.

Brain Inj 2019 30;33(3):266-281. Epub 2018 Nov 30.

c Centre for Rehabilitation of Brain Injury , Copenhagen , Denmark.

Objective: To compare the effectiveness of a specialized, interdisciplinary rehabilitation (S-REHAB) with standard care (STAND) for people with persistent post-concussive symptoms (PPCS > 6 month).

Design: Randomized controlled trial.

Participants: Eighty-nine adults. Read More

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http://dx.doi.org/10.1080/02699052.2018.1552022DOI Listing
November 2018
2 Reads