Neurol Neuroimmunol Neuroinflamm 2022 Jul 14;9(4). Epub 2022 Jun 14.
From the Department of Medicine (N.S.), Surgery and Neuroscience, University of Siena, Siena, Italy; Department of Radiology (F.B.), VU University Medical Center, Amsterdam, The Netherlands; UCL Institute of Neurology (F.B.), London, UK; Department of Neurology-Neuroimmunology (X.M.), Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Hospital Universitario Vall d'Hebron, Universitat Autonoma de Barcelona, Spain; Multiple Sclerosis Center (A.A.), Sheba Academic Medical Center, Ramat Gan, Israel; Department of Neurology (T.D.), University Hospital Basel, Switzerland; Department of Neurology (A.C.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Ingham Institute for Applied Medical Research (S.H.), University of New South Wales Medicine, Sydney, Australia; Department of Neurosciences (A.P.), Université de Montréal, QC, Canada; Experimental Neurophysiology Unit (L.L.), Vita-Salute San Raffaele University, Milan, Italy; The Blizard Institute (K.S.), Centre for Neuroscience, Surgery & Trauma, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, UK and; Clinical Board Medicine (Neuroscience) (K.S.), The Royal London Hospital, Barts Health NHS Trust, UK; Danish MS Center (F.S.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Clinical Medicine (F.S.), University of Copenhagen, Denmark; Univ. Lille (P.V.), Inserm U1172 LilNCog, CHU Lille, FHU Precise, France; Department of Neurology (H.W.), Institute of Translational Neurology, University of Münster, Germany; the healthcare business of Merck KGaA (B.K.), Darmstadt, Germany; and Ares Trading S.A. (S.R.), Eysins, Switzerland (an affiliate of Merck KGaA, Darmstadt, Germany).
Background And Objectives: The onset of action for high-efficacy immunotherapies in multiple sclerosis (MS) is an important parameter. This study (MAGNIFY-MS) evaluates the onset of action of cladribine tablets by observing changes in combined unique active (CUA) MRI lesion counts during the first 6 months of treatment in patients with highly active relapsing MS.
Methods: MRI was performed at screening, baseline, and at months 1, 2, 3, and 6 after initiating treatment with cladribine tablets 3. Read More