3,544 results match your criteria Brain Imaging in Lymphoma


Prognostic significance of locally invaded sites and tissue types in patients with nasal extranodal natural-killer/T-cell lymphoma: a single-center, retrospective analysis.

Chin Med J (Engl) 2019 Jan 10. Epub 2019 Jan 10.

Key Laboratory of Head and Neck Molecular Pathological Diagnosis, Capital Medical University, Beijing 100730, China.

Background: Extranodal natural-killer/T-cell lymphoma (ENKTL), nasal-type, is an aggressive entity within the World Health Organization (WHO) classification of lymphoid tumors. The International Prognostic Index (IPI) is reported to be prognostically meaningful for ENKTL, but lacks discriminatory power for stage I/II ENKTL with extensive local invasion. This study aimed to evaluate the prognostic effects of local invasion by site and tissue type in patients with ENKTL. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000263DOI Listing
January 2019

Meningeal enhancement depicted by magnetic resonance imaging in tumor patients: neoplastic meningitis or therapy-related enhancement?

Neuroradiology 2019 Apr 18. Epub 2019 Apr 18.

Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Purpose: To assess the prevalence of false-positive meningeal contrast enhancement in patients with solid tumors who were undergoing chemotherapy.

Methods: A total of 2572 magnetic resonance imaging (MRI) examinations of the brain were retrospectively evaluated by two readers for the presence of pathological meningeal contrast enhancement conspicuous for neoplastic meningitis. These patients either had malignant melanoma, breast or lung cancer, or lymphoma. Read More

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http://link.springer.com/10.1007/s00234-019-02215-y
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http://dx.doi.org/10.1007/s00234-019-02215-yDOI Listing
April 2019
1 Read

A Case of Reversible Cerebral Vasoconstriction Syndrome Triggered by High-Dose Methotrexate in a Boy With Lymphoma.

Headache 2019 Apr 15. Epub 2019 Apr 15.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by thunderclap headaches and transient segmental cerebral arterial vasoconstriction. Many drugs have been identified as triggers of RCVS. However, RCVS induced by methotrexate (MTX), an antimetabolite agent, has never been reported. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/head.13526
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http://dx.doi.org/10.1111/head.13526DOI Listing
April 2019
6 Reads

The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats.

Front Cell Neurosci 2019 29;13:123. Epub 2019 Mar 29.

Department of Endocrinology, Jinshan Hospital, Fudan University, Shanghai, China.

Cognitive dysfunction is one of the serious complications induced by status epilepticus (SE), which has a significant negative impact on patients' quality of life. Previous studies demonstrated that the pathophysiological changes after SE such as oxidative stress, inflammatory reaction contribute to neuronal damage. A recent study indicated that preventive astaxanthin (AST) alleviated epilepsy-induced oxidative stress and neuronal apoptosis in the brain. Read More

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https://www.frontiersin.org/article/10.3389/fncel.2019.00123
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http://dx.doi.org/10.3389/fncel.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449650PMC
March 2019
2 Reads

Application of MR morphologic, diffusion tensor, and perfusion imaging in the classification of brain tumors using machine learning scheme.

Neuroradiology 2019 Apr 4. Epub 2019 Apr 4.

Department of Diagnostic Imaging, Sheba Medical Center, Ramat-Gan, Israel, 2 Sheba Rd, 52621, Ramat Gan, Israel.

Purpose: While MRI is the modality of choice for the assessment of patients with brain tumors, differentiation between various tumors based on their imaging characteristics might be challenging due to overlapping imaging features. The purpose of this study was to apply a machine learning scheme using basic and advanced MR sequences for distinguishing different types of brain tumors.

Methods: The study cohort included 141 patients (41 glioblastoma, 38 metastasis, 50 meningioma, and 12 primary central nervous system lymphoma). Read More

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http://dx.doi.org/10.1007/s00234-019-02195-zDOI Listing
April 2019
3 Reads

Venture in 101 Cranial Punctures: A Comparative Study between Frame-based versus Frameless Biopsy of 101 Intracranial Space Occupying Lesion.

Asian J Neurosurg 2019 Jan-Mar;14(1):175-180

Department of Neurosurgery, National Institute of Neurological and Allied Sciences, Kathmandu, Nepal.

Background: Presumptive diagnosis based solely on the clinical picture and imaging is not sufficient to provide appropriate treatment with certainty and hence histopathological confirmation of intracranial space occupying lesion (ICSOL) is essential. Needle biopsy via stereotactic frame-based or frameless neuronavigation technique is efficient procedure. The objective of this study is to compare their accuracy and efficacy and safety. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_137_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417303PMC
April 2019
1 Read

Magnetic Resonance Imaging-guided Stereotactic Biopsy: A Review of 83 Cases with Outcomes.

Asian J Neurosurg 2019 Jan-Mar;14(1):90-95

Department of Neurosurgery, Kent Hospital, Izmir, Turkey.

Background: The purpose of this study was to determine the relationship between the radiological and histopathological distribution of the cerebral lesions diagnosed with stereotactic biopsy (STB) procedure and its outcomes.

Materials And Methods: In the current study, a retrospective analysis of 83 patients that underwent the STB in our clinic from January 2011 to December 2015 was made. T1-weighted contrast-enhanced cranial magnetic resonance imaging examinations were performed on patients on whom Leksell stereotactic frame system was installed. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_81_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417362PMC
April 2019
1 Read

Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient.

Rev Assoc Med Bras (1992) 2019 Feb;65(2):136-140

Department of Radiology, Faculty of Medical Sciences, University of Campinas, Campinas, São Paulo, SP, Brasil.

We describe the case of a female patient, 52 years old, with dizziness and left motor incoordination for 2 weeks. Brain MRI magnetic resonance imaging) revealed a hyperintense lesion on T2-weighted images, without restricted diffusion, in the left middle cerebellar peduncle. Spectroscopy demonstrated peak of lipids and perfusion did not show any elevation in relative cerebral blood volume (rCBV). Read More

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http://dx.doi.org/10.1590/1806-9282.65.2.136DOI Listing
February 2019
1 Read
0.915 Impact Factor

Neurological toxicities associated with chimeric antigen receptor T-cell therapy.

Brain 2019 Mar 19. Epub 2019 Mar 19.

Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Chimeric antigen receptor T cell therapy has become an important tool in the treatment of relapsed and refractory malignancy; however, it is associated with significant neurological toxicity. We characterized the neurological toxicity associated with chimeric antigen receptor T-cell therapy in a consecutive series of 100 patients up to 2 months post transfusion, 28 of whom were obtained from chart review and the others by prospective observation. The underlying neoplasms were lymphoma (74%), myeloma (14%), leukaemia (10%), and sarcoma (2%). Read More

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http://dx.doi.org/10.1093/brain/awz053DOI Listing
March 2019
3 Reads
9.196 Impact Factor

Primary central nervous system lymphoma in patients with and without HIV infection: a multicenter study and comparison with U.S national data.

Cancer Causes Control 2019 May 19;30(5):477-488. Epub 2019 Mar 19.

Department of Radiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.

Purpose: Primary central nervous system lymphoma (PCNSL) in patients living with HIV (PLWH) is a distinct entity; however, the management is adopted from patients without HIV. The study aims to examine the differences in presentation, treatment, and outcomes of PCNSL patients with or without HIV.

Methods: We retrospectively compared the characteristics of 144 patients with PCNSL with and without HIV, and analyzed factors associated with overall and progression-free survival. Read More

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http://dx.doi.org/10.1007/s10552-019-01144-8DOI Listing
May 2019
1 Read

Recurrent Epstein-Barr Virus-positive (EBV+) Primary Central Nervous System Lymphoma (PCNSL) in a Patient with Clinical Features of Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS).

Intern Med 2019 15;58(6):849-854. Epub 2019 Mar 15.

Department of Neurology, Kyoto University Graduate School of Medicine, Japan.

Primary central nervous system lymphoma (PCNSL) and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) can share clinical features and may be indistinguishable, even after brain biopsy. We encountered a case of Epstein-Barr virus-positive (EBV+) PCNSL recurrence in a patient with clinical features of CLIPPERS, and repeat brain biopsy was required to reach the correct diagnosis. Four years after the initial diagnosis and treatment of PCNSL, "peppering" punctate enhanced lesions with transient steroid responsiveness were detected during brain magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.2169/internalmedicine.1246-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465023PMC

[A Patient with Progressive Multifocal Leukoencephalopathy Who Developed Bálint Syndrome Improved by Combination Therapy Using Mefloquine and Mirtazapine].

Brain Nerve 2019 Mar;71(3):281-286

Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine.

We describe a 62-year-old man who developed subacute visual loss after cord blood stem cell transplantation for malignant lymphoma. Brain magnetic resonance imaging (MRI) showed bilateral hyperintense lesions in the occipital and parietal lobes. A diagnosis of progressive multifocal encephalopathy (PML) was established following brain biopsy and detection of JC virus (JCV) deoxyribonucleic acid (DNA) in the cerebrospinal fluid (CSF). Read More

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http://dx.doi.org/10.11477/mf.1416201256DOI Listing
March 2019
2 Reads

Intracranial cell lymphomas that mimic meningiomas: a case report to understand complex genetic, radiological and histopathological entities.

World Neurosurg 2019 Feb 21. Epub 2019 Feb 21.

Department of Neurosurgery, La Pitié-Salpétrière Hospital, Paris, France. Electronic address:

We describe a patient affected by a T-cell primary central nervous system lymphoma (PCNSL) with highly aberrant specific B-cell markers (CD79a and CD20). An unusual imaging presentation leads us to misdiagnose this lesion for a meningioma and perform surgical resection. We think that this infrequent anatomical presentation might be due to the aberrant specific B-cell markers (CD79a and CD20) genotype expression. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.298DOI Listing
February 2019
2 Reads

Magnetic resonance texture analysis utility in differentiating intraparenchymal neurosarcoidosis from primary central nervous system lymphoma: a preliminary analysis.

Neuroradiol J 2019 Feb 21:1971400919830173. Epub 2019 Feb 21.

4 Institute of Nuclear Medicine, University College London, Institute of Nuclear Medicine, UK.

Purpose: Neurosarcoidosis and primary central nervous system lymphomas, although distinct disease entities, can both have overlapping neuroimaging findings. The purpose of our preliminary study was to assess if magnetic resonance texture analysis can differentiate parenchymal mass-like neurosarcoidosis granulomas from primary central nervous system lymphomas.

Methods: A total of nine patients was evaluated, four with parenchymal neurosarcoidosis granulomas and five with primary central nervous system lymphomas. Read More

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http://journals.sagepub.com/doi/10.1177/1971400919830173
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http://dx.doi.org/10.1177/1971400919830173DOI Listing
February 2019
5 Reads

Adult Burkitt lymphoma- an Island between lymphomas and leukemias.

J Community Hosp Intern Med Perspect 2019 11;9(1):25-28. Epub 2019 Feb 11.

Department of Internal Medicine, Hackensack Meridian Health- Ocean Medical Centre, Brick, NJ, USA.

: Burkitt lymphoma is a rare, aggressive and rapidly fatal, B-cell non-Hodgkin's lymphoma. It has an incidence of 0.4/100,000 age-adjusted to the USA standard population. Read More

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https://www.tandfonline.com/doi/full/10.1080/20009666.2019.1
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http://dx.doi.org/10.1080/20009666.2019.1574545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374956PMC
February 2019
4 Reads

Differentiation of primary central nervous system lymphoma from high-grade glioma and brain metastasis using arterial spin labeling and dynamic contrast-enhanced magnetic resonance imaging.

Eur J Radiol 2019 Mar 8;112:59-64. Epub 2019 Jan 8.

Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Background And Purpose: Conventional magnetic resonance imaging (MRI) is sometimes difficult to distinguish primary central nervous system lymphoma (PCNSL) from other malignant brain tumors effectively. The study aimed to evaluate the diagnostic performance of arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE)-derived permeability parameters to differentiate PCNSL from high-grade glioma (HGG) and brain metastasis.

Materials And Methods: Eight patients with PCNSL, twenty one patients with HGG and six brain metastasis underwent preoperative 3. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X193000
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http://dx.doi.org/10.1016/j.ejrad.2019.01.008DOI Listing
March 2019
7 Reads

Diagnostic Yield and Complication of Frameless Stereotactic Brain Biopsy.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):78-84

Department of Surgery, Division of Neurosurgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

Background: With the advancement of neuronavigation technologies, frameless stereotactic brain biopsy has been developed. Previous studies proved that frameless stereotactic brain biopsy was as effective and safe as frame-based stereotactic brain biopsy. The authors aimed to find the factors associated with diagnostic yield and complication rate of frameless intracranial biopsy. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_166_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337997PMC
February 2019

Intravascular large B-cell lymphoma presenting with hearing loss and dizziness: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14470

Department of Neurology.

Rationale: Intravascular large B-cell lymphoma (IVLBCL) is a type of malignant lymphoma in which neoplastic B cells proliferate selectively within the lumina of small- and medium-sized vessels. Patients with IVLBCL frequently develop neurological manifestations during their disease course. Patients are known to often develop various neurological manifestations, but there are only a few reports of IVLBCL whose initial symptoms are deafness and/or disequilibrium. Read More

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http://dx.doi.org/10.1097/MD.0000000000014470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407998PMC
February 2019
2 Reads

Relapsing Long-Lasting Garcin Syndrome Revealing Skull Base Diffuse B Cell Lymphoma: The Diagnosis through the "Hartel's Route".

J Neurol Surg B Skull Base 2019 Feb 8;80(1):105-108. Epub 2018 Jun 8.

Department of NESMOS (Neurosciences Mental Health and Sensory Organs), School of Medicine and Psychology, "Sant'Andrea" Hospital, "Sapienza" University of Rome, Rome, Italy.

The Garcin syndrome is a rare condition characterized by multiple unilateral cranial nerve palsy, without neither long-tract involvement nor intracranial hypertension. Non-Hodgkin lymphoma is a systemic malignant disease that localizes in a minority of cases in the central nervous system. We report a case of Garcin syndrome that revealed a diffuse large B cell lymphoma (DLBCL) located in the skull base and in the right kidney. Read More

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http://dx.doi.org/10.1055/s-0038-1657794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365233PMC
February 2019
2 Reads

Diffuse large B-cell lymphoma of the central nervous system presenting as "lymphomatosis cerebri" and dementia in elderly man: Case report and review of the literature.

Medicine (Baltimore) 2019 Feb;98(6):e14367

Department of Hematology, Hospital Israelita Albert Einstein.

Rationale: Lymphomatosis cerebri is a rare form of PCNSL, characterized by diffuse infiltration of lymphoma cells in cerebral parenchyma, without mass-formation and mild or no contrast enhancement on magnetic resonance (MR) imaging. There are less than 50 cases described in the literature under the term Lymphomatosis cerebri.

Patient Concerns: A 74-year-old man presented to our service with progressive dementia for 12 months and accelerated cognitive decline within the last two months. Read More

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http://dx.doi.org/10.1097/MD.0000000000014367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380721PMC
February 2019
3 Reads

A Rare Case of Primary Central Nervous System Lymphoma in an Adolescent Female Treated with High-Dose Methotrexate and Rituximab-Based Chemoimmunotherapy and Consolidation Whole Brain Radiotherapy.

Pediatr Neurosurg 2019 22;54(1):57-65. Epub 2019 Jan 22.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Primary central nervous system lymphoma (PCNSL) is a rare pediatric brain tumor. A 16-year-old female patient presented to the clinic with complaints of multiple episodes of generalized tonic clonic seizures, nystagmus, and weakness on the left side of the body for 3 weeks. She had similar symptoms, waxing and waning for the last 2 years, responding to corticosteroids. Read More

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http://dx.doi.org/10.1159/000495789DOI Listing
January 2019
5 Reads

Demyelinating lesions behaving like aggressive tumours on advanced MRI techniques.

Neuroradiol J 2019 Apr 22;32(2):103-107. Epub 2019 Jan 22.

4 Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, USA.

Tumefactive demyelinating lesions are a rare disorder in which inflammatory demyelination manifests as solitary or multiple focal brain lesions (greater than 2 cm in size), which can be mistaken for glioma, lymphoma, metastasis and in some cases even brain abscess. The symptomatology of tumefactive demyelinating lesions depends on the white matter area involved and includes quickly progressing neurological deterioration of motor, sensory and visual function, praxis, language and mood impairment, as well as seizures. Recognising the key imaging features in a patient with a prior history of demyelination may expedite appropriate management. Read More

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http://dx.doi.org/10.1177/1971400919826394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410458PMC
April 2019
5 Reads

Fluorodeoxyglucose Detected Changes in Brain Metabolism After Chemotherapy in Pediatric Non-Hodgkin Lymphoma.

Pediatr Neurol 2019 Mar 22;92:37-42. Epub 2018 Nov 22.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Nuclear Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Background: Potential neurocognitive dysfunction after chemotherapy is a worrisome long-term outcome. Our objective was to evaluate the effect on brain metabolism in pediatric patients with non-central nervous system cancer treated with chemotherapy by analyzing brain data from serial whole-body fluorodeoxyglucose positron emission tomography/computed-tomography (FDG-PET/CT) scans taken before and sequentially after therapy.

Methods: Fourteen pediatric patients diagnosed with lymphoma and treated with systemic and prophylactic intrathecal chemotherapy were included. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.019DOI Listing
March 2019
4 Reads

Central Nervous System Peripheral T Cell Lymphoma Manifesting as Lymphomatosis Cerebri That Was Misdiagnosed as Neuro-Behçet's Disease: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):806-813. Epub 2018 Nov 29.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Background: Lymphomatosis cerebri (LC) is a unique form of primary central nerves lymphoma (PCNSL), which presents as diffuse infiltration of lymphoma cells characteristically in the white matter rather than tumor formation. However, the involvement of central nervous system (CNS) is unclear because of the lack of contrast enhancement.

Case Presentation: We treated a 53-year-old woman with LC and brain lesions resembling neuro-Behcet's disease. Read More

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http://dx.doi.org/10.1159/000495033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323408PMC
November 2018
14 Reads

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in limited cutaneous sclerosis: a rare disease combination.

BMJ Case Rep 2019 Jan 7;12(1). Epub 2019 Jan 7.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

A 26-year-old patient of limited cutaneous sclerosis presented to us with insidious-onset posterior fossa symptoms of headache, vomiting, vertigo and gait imbalance, progressing over a period of 3 weeks. A diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids was made by combining the clinical features with radiological evidence showing punctate infiltration of the pons, brainstem and cerebellum. Relevant differentials in the form of neurosarcoid, infections, central nervous system (CNS) lymphoma and Neuro-Behcet's disease were ruled out by history and investigations. Read More

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http://dx.doi.org/10.1136/bcr-2018-226259DOI Listing
January 2019
5 Reads

The Radiological Imaging Features of Easily Misdiagnosed Epithelioid Glioblastoma in Seven Patients.

World Neurosurg 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology, Nanjing Medical University Affiliated Nanjing Brain Hospital, Nanjing, China.

Objective: We review the radiological imaging features and report histopathological findings of 7 adult patients with epithelioid glioblastoma (eGBM), which was a newly revised subtype of glioblastoma.

Methods: Seven adult patients with a diagnosis of eGBM on a brain tissue specimen were retrospectively confirmed by pathology. The tumor magnetic resonance imaging characteristics such as location, number, edema, necrosis, hemorrhage, enhancement, diffusion-weighted image, apparent diffusion coefficient, magnetic resonance spectroscopy, dynamic susceptibility contrast-perfusion-weighted imaging, and histopathological findings were documented. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.128DOI Listing
January 2019
3 Reads

Cultured Cells Isolated from CNS Indolent B-Cell Lymphoma Have Characteristics of Mesenchymal Stem Cells: A Clinical Case and Scientific Research.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):169-174

Laboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria.

The case report presented here describes the culturing and characterization of mesenchymal stem cells (MSCs) isolated from a primary indolent B-cell lymphoma, located in the CNS of an immunocompetent patient. The presence of such cells in the tumor mass can further elucidate the pathogenesis of the disease and reveal possible future approaches for its treatment. We present a case report of a 61-year-old immunocompetent woman who had an episode of confusion with numbness in the right leg and the right arm, slurred and dysarthric speech and urine incontinence. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305270PMC
July 2018
4 Reads

Imaging features (CT, MRI, MRS, and PET/CT) of primary central nervous system lymphoma in immunocompetent patients.

Neurol Sci 2019 Mar 22;40(3):535-542. Epub 2018 Dec 22.

Institute of Neurosurgery, Navy General Hospital, Beijing, 100048, China.

Background: Because of the low incidence of primary central nervous system lymphoma (PCNSL) in non-HIV individuals and because of the lack of specific clinical manifestations and auxiliary examinations, the disease is easily missed or misdiagnosed.

Objective: To analyze the imaging features of PCNSL in non-HIV patients.

Methods: This was a retrospective study of patients with PCNSL treated between January 2001 and December 2011 at the Naval General Hospital (Beijing, China). Read More

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http://dx.doi.org/10.1007/s10072-018-3669-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433804PMC
March 2019
2 Reads

Solitary Primary Central Nervous System Lymphoma Mimicking Third Ventricular Colloid Cyst-Case Report and Review of Literature.

World Neurosurg 2019 Mar 19;123:286-294. Epub 2018 Dec 19.

Hamad Medical Corporate, Neurosurgery, Doha, Qatar.

Background: Primary central nervous system lymphoma is a rare malignant tumor of the central nervous system. It is associated with poor prognosis and accounts for 0.7%-0. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.026DOI Listing
March 2019
2 Reads

Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign".

Intern Med 2019 Apr 18;58(8):1157-1162. Epub 2018 Dec 18.

Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

We herein report the case of a 60-year-old man with a "target sign" in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis. F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. Read More

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http://dx.doi.org/10.2169/internalmedicine.1156-18DOI Listing
April 2019
2 Reads

Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.

Neurol Clin Pract 2018 Oct;8(5):379-388

Departments of Neurology (DI, RE, KM, Sucipto, DO, DNL), Microbiology (DCL, A. Karuniawati), Radiology (REY, RM), Internal Medicine (EY, THK), Clinical Pathology (IST, DW), and Parasitology (RW, RA, A. Kurniawan), Cipto Mangunkusumo Hospital-Faculty of Medicine Universitas Indonesia; Eijkman Institute for Molecular Biology (UAJ, DS, KSAM); Eijkman-Oxford Clinical Research Unit (UAJ), Jakarta, Indonesia; Department of Internal Medicine and Radboud Center for Infectious Diseases (AvL, RvC), Radboud University Medical Center, Nijmegen, the Netherlands; TB/HIV Research Center (BA, SD, LC, ARG), Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; and Centre for Tropical Medicine and Global Health (RvC), Nuffield Department of Medicine, University of Oxford, UK.

Background: Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, in low-resource settings.

Methods: From January 2015 to April 2016, we prospectively included all adults with suspected CNS infection in a referral hospital in Jakarta, Indonesia. Systematic screening included HIV testing, CSF examination, and neuroimaging. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276332PMC
October 2018
12 Reads

Incidental Detection of Plasma Cell Neoplasm on 18F-Choline PET/CT Imaging.

Clin Nucl Med 2019 Feb;44(2):140-141

From the Departments of Nuclear Medicine, and.

F-Fluorocholine is a relatively new, extremely versatile radiotracer for detecting proliferative or mitogenic activity. Its diagnostic potential has been explored in cancers of the prostate, liver, esophagus, breast, brain, and lung, as well as lymphoma, sarcoma, melanoma, and parathyroid adenomas. The authors present a case where fluorocholine PET/CT performed for characterizing a space-occupying lesion in the brain revealed intensely tracer-avid skull lesions with intracranial soft tissue component and multiple other skeletal lesions. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9731
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http://dx.doi.org/10.1097/RLU.0000000000002415DOI Listing
February 2019
12 Reads

Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia.

J Vet Intern Med 2019 Mar 18;33(2):856-861. Epub 2018 Dec 18.

Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

A 1-year, 8-month-old Rhodesian Ridgeback was presented with obtundation, ambulatory tetraparesis, and myoclonus. Initial clinical findings included ionized hypercalcemia with an apparent marked increase in parathyroid hormone, thrombocytopenia, and nonregenerative anemia. Low numbers of circulating atypical cells were noted on blood film evaluation. Read More

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http://dx.doi.org/10.1111/jvim.15398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430899PMC
March 2019
4 Reads

Peripheral nervous system involvement in lymphomas.

J Peripher Nerv Syst 2019 Mar 8;24(1):5-18. Epub 2019 Jan 8.

Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy.

The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune-mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jns.12295
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http://dx.doi.org/10.1111/jns.12295DOI Listing
March 2019
13 Reads
2.758 Impact Factor

Gadolinium-enhanced imaging of pediatric thoracic lymphoma: is intravenous contrast really necessary?

Eur Radiol 2019 May 13;29(5):2553-2559. Epub 2018 Dec 13.

Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.

Objectives: Increasing awareness of potential side effects from gadolinium-based contrast agents has underlined the need for contrast-free magnetic resonance imaging (MRI). Numerous recent articles evaluated the risk of potential brain deposits, with the result that research is putting the focus more on alternative unenhanced imaging techniques. The aim of this study was to determine the need for contrast media for chest MRI in primary staging and follow-up care of lymphoma. Read More

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http://link.springer.com/10.1007/s00330-018-5859-3
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http://dx.doi.org/10.1007/s00330-018-5859-3DOI Listing
May 2019
19 Reads

[Magnetic resonance imaging features for primary brain lymphoma].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1118-1122

Department of Diagnostic Radiology, Hunan Cancer Hospital, Changsha 410013, China.

Objective: To investigate the magnetic resonance imaging (MRI) features for primary brain lymphoma and improve its diagnosis and differential diagnosis.
 Methods: The clinical and MRI data from 14 patients with primary brain lymphoma were retrospectively reviewed.
 Results: Fourteen patients, including 5 males and 9 females, were (55±8) years old. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.10.012DOI Listing
October 2018
2 Reads

Prospective phase II clinical trial of autologous haematopoietic stem cell transplant for treatment refractory multiple sclerosis.

J Neurol Neurosurg Psychiatry 2019 May 11;90(5):514-521. Epub 2018 Dec 11.

Department of Haematology, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.

Background: Autologous haematopoietic stem cell transplantation (AHSCT) has been explored as a therapeutic intervention in multiple sclerosis (MS) over the last two decades; however, prospective clinical trials of the most common myeloablative conditioning regimen, BEAM, are limited. Furthermore, patient selection, optimal chemotherapeutic regimen and immunological changes associated with disease response require ongoing exploration. We present the outcomes, safety and immune reconstitution (IR) of patients with active, treatment refractory MS. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319446DOI Listing

Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma.

J Neuroophthalmol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Ophthalmology (MD, JW, CO), Neurology (MD, AEM), and Pathology (EL), Weill Cornell Medical College, New York, New York.

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL).

Methods: Case report and review of the literature.

Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000722DOI Listing
October 2018
23 Reads

BK virus nephropathy and multiorgan involvement in a child with heart transplantation
.

Clin Nephrol 2019 Feb;91(2):107-113

BK virus is a known cause of renal failure in kidney transplant recipients, but there is little data regarding its effect on native kidneys in heart transplant patients. Here, we describe the case of a child who underwent heart transplantation and was later diagnosed with BK virus with multiorgan involvement. This patient was diagnosed with dilated cardiomyopathy at 4 months of age and underwent heart transplantation at the age of 5 years. Read More

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http://dx.doi.org/10.5414/CN109520DOI Listing
February 2019
6 Reads

Differentiation of Primary Central Nervous System Lymphoma From Glioblastoma: Quantitative Analysis Using Arterial Spin Labeling and Diffusion Tensor Imaging.

World Neurosurg 2019 Mar 29;123:e303-e309. Epub 2018 Nov 29.

Department of Diagnostic Radiology, Kafr Elsheak Faculty of Medicine, Kafr Elsheak, Egypt.

Objective: Differentiation of primary central nervous system lymphoma (PCNSL) from glioblastoma using arterial spin labeling perfusion and diffusion tensor imaging (DTI).

Methods: We performed a prospective study of 31 patients with a provisional diagnosis of PCNSL and glioblastoma who underwent conventional magnetic resonance imaging, DTI, and arterial spin labeling of the brain. The tumor blood flow (TBF), mean diffusivity (MD) plus fractional anisotropy (FA) of the mass were measured. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183271
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http://dx.doi.org/10.1016/j.wneu.2018.11.155DOI Listing
March 2019
5 Reads
2.417 Impact Factor

Experience with 102 Frameless Stereotactic Biopsies Using the neuromate Robotic Device.

World Neurosurg 2019 Mar 27;123:e450-e456. Epub 2018 Nov 27.

Department of Neurosurgery, Bethel Clinic, Bielefeld, Germany. Electronic address:

Objective: Stereotactic biopsy is a standard procedure in neurosurgery. In addition to or even replacing frame-based stereotaxy, some centers also use frameless imaging-based techniques and more recently robotic systems. Here we report a retrospective analysis of our experience with 102 consecutive biopsies performed in our institution using the neuromate robotic device. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.187DOI Listing
March 2019
5 Reads

New Radiologic Findings of Hypertrophic Olivary Degeneration in 2 Patients with Brainstem Lymphoma.

World Neurosurg 2019 Mar 26;123:464-468.e1. Epub 2018 Nov 26.

Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan.

Background: Hypertrophic olivary degeneration (HOD) is a rare neurological condition of trans-synaptic degeneration caused by disruption of the dentatorubro-olivary pathway. We present new radiologic findings of HOD in 2 cases of brainstem lymphoma.

Case Description: A 35-year-old woman (Case 1) and a 69-year-old man (Case 2) presented with remarkably similar clinical courses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183272
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http://dx.doi.org/10.1016/j.wneu.2018.11.161DOI Listing
March 2019
3 Reads

Bilateral Proptosis in a Child: A Rare Presentation of Acute Lymphoblastic Leukemia.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):511-513

Division of Pediatric Hematogy/Oncology, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Purpose: Acute lymphoblastic leukemia (ALL), a common hematological malignancy observed in children, typically presents with fever, pallor, easy bruising, hepatosplenomegaly and lymphadenopathy. However, when ALL manifests with unusual signs and the blood counts and peripheral smears are normal, it causes a diagnostic dilemma.

Case Report: We report a 5-year-old boy who presented with bilateral proptosis as the initial manifestation of ALL. Read More

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http://dx.doi.org/10.4103/jovr.jovr_2_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210864PMC
November 2018
2 Reads

Brain invasion by chronic lymphocytic leukemia.

Neuropathology 2019 Feb 25;39(1):54-57. Epub 2018 Nov 25.

Department of Neurosurgery, Dokkyo Medical University, Mibu-machi, Japan.

Brain invasion by chronic lymphocytic leukemia (CLL) is very rare, and only a handful of cases have been reported. We here report a case of 61-year-old woman who had been treated for CLL for 14 years presenting with a progressive mental disturbance. Magnetic resonance imaging (MRI) showed discontinuous ring-enhancing lesions compatible with the "open ring" sign, which was considered a demyelinating disorder, in both the frontal lobes. Read More

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http://dx.doi.org/10.1111/neup.12525DOI Listing
February 2019
1 Read

Comparison between cytospin and liquid-based cytology in cerebrospinal fluid diagnosis of neoplastic diseases: A single institution experience.

Cytopathology 2019 Mar 9;30(2):236-240. Epub 2019 Jan 9.

Division of Anatomic Pathology and Histology, Foundation "A. Gemelli" University Hospital, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: The current tools available for detecting malignant neoplasms in the cerebrospinal fluid (CSF) are neurological examination, followed by neuroimaging, cytology and molecular techniques. To highlight the role of cytology the diagnosis of metastatic tumours in CSF samples, we present our experience using cytospin and ThinPrep liquid-based cytology.

Methods: A retrospective analysis was conducted using the pathological records of 8181 cytological specimens of CSF, which were diagnosed over a 17-year period. Read More

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http://doi.wiley.com/10.1111/cyt.12659
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http://dx.doi.org/10.1111/cyt.12659DOI Listing
March 2019
9 Reads

Assessment of Primary Brain Lymphoma Using Multimodal Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy.

Asian J Neurosurg 2018 Oct-Dec;13(4):1205-1208

Department of Biophysics, Clinical Neuroscience Laboratory, Faculty of Medicine and Pharmacy, University of Fez, Fez, Morocco.

Objectives: The primary lymphoma of the central nervous system is a cancer rare. The diagnosis of this tumoral entity must be considered as an emergency considering the therapeutical involved. Therefore, we report this entity while reporting diagnostic challenges. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_137_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208237PMC
November 2018
18 Reads

Machine learning applications for the differentiation of primary central nervous system lymphoma from glioblastoma on imaging: a systematic review and meta-analysis.

Neurosurg Focus 2018 Nov;45(5):E5

3Department of Neurosurgery, The University of Texas Medical Branch, Galveston, Texas.

OBJECTIVEGlioblastoma (GBM) and primary central nervous system lymphoma (PCNSL) are common intracranial pathologies encountered by neurosurgeons. They often may have similar radiological findings, making diagnosis difficult without surgical biopsy; however, management is quite different between these two entities. Recently, predictive analytics, including machine learning (ML), have garnered attention for their potential to aid in the diagnostic assessment of a variety of pathologies. Read More

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https://thejns.org/view/journals/neurosurg-focus/45/5/articl
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http://dx.doi.org/10.3171/2018.8.FOCUS18325DOI Listing
November 2018
12 Reads

Cerebellar large B-cell lymphoma: a case report.

J Med Case Rep 2018 Nov 17;12(1):341. Epub 2018 Nov 17.

Minneapolis Veterans Affairs Healthcare System, Section of Hospital Medicine, Minneapolis, MN, USA.

Background: Primary central nervous system lymphoma is a rare, malignant non-Hodgkin lymphoma that can arise in the brain, spinal cord, eye, leptomeninges, or cranial nerves. Primary central nervous system lymphoma is rare, accounting for 2-6% of all primary brain neoplasms and 1-2% of all non-Hodgkin lymphomas, and it usually presents as a solitary lesion. Cerebellar involvement is present in only 9% of cases. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13256-018-1880-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240289PMC
November 2018
16 Reads

Machine learning based on multi-parametric magnetic resonance imaging to differentiate glioblastoma multiforme from primary cerebral nervous system lymphoma.

Eur J Radiol 2018 Nov 14;108:147-154. Epub 2018 Sep 14.

Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuoku, Kumamoto, 860-8556, Japan. Electronic address:

Purpose: To evaluate the performance of a machine learning method based on texture features in multi-parametric magnetic resonance imaging (MRI) to differentiate a glioblastoma multiforme (GBM) from a primary cerebral nervous system lymphoma (PCNSL).

Materials And Methods: We included 70 patients who underwent contrast enhanced brain MRI at 3 T with brain tumors diagnosed as GBM (n = 45) and PCNSL (n = 25) in this retrospective study. Twelve histograms and texture parameters were assessed on T2-weighted images (T2WIs), apparent diffusion coefficient maps, relative cerebral blood volume (rCBV) map, and contrast-enhanced T1-weighted images (CE-T1WIs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.017DOI Listing
November 2018
19 Reads

Preoperative localization of the sensorimotor cortex and measurement of tumor perfusion in a single acquisition using ASL technique.

J Clin Neurosci 2019 Jan 1;59:367-371. Epub 2018 Nov 1.

Department of Radiology, Masan University, Changwon, Republic of Korea.

Resting state fMRI (rs-fMRI) using arterial spin labelling (ASL) technique was performed for the preoperative localization of the sensorimotor cortex in a patient with lymphoma and the results were compared to those of task-based (tb) and rs-fMRI studies using blood oxygenation level-dependent (BOLD) sequence. Rs-fMRI using ASL showed similar results in the regions of the sensorimotor network to those of tb- and rs-fMRI fMRI using BOLD. ASL technique has a potential in clinical practice because all of brain perfusion imaging, cerebral blood flow measurement, and rs-fMRI study can be performed at a single acquisition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868173000
Publisher Site
http://dx.doi.org/10.1016/j.jocn.2018.10.098DOI Listing
January 2019
16 Reads
1.320 Impact Factor