3,507 results match your criteria Brain Imaging in Lymphoma


Diagnostic Yield and Complication of Frameless Stereotactic Brain Biopsy.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):78-84

Department of Surgery, Division of Neurosurgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.

Background: With the advancement of neuronavigation technologies, frameless stereotactic brain biopsy has been developed. Previous studies proved that frameless stereotactic brain biopsy was as effective and safe as frame-based stereotactic brain biopsy. The authors aimed to find the factors associated with diagnostic yield and complication rate of frameless intracranial biopsy. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_166_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337997PMC
February 2019

Intravascular large B-cell lymphoma presenting with hearing loss and dizziness: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14470

Department of Neurology.

Rationale: Intravascular large B-cell lymphoma (IVLBCL) is a type of malignant lymphoma in which neoplastic B cells proliferate selectively within the lumina of small- and medium-sized vessels. Patients with IVLBCL frequently develop neurological manifestations during their disease course. Patients are known to often develop various neurological manifestations, but there are only a few reports of IVLBCL whose initial symptoms are deafness and/or disequilibrium. Read More

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http://dx.doi.org/10.1097/MD.0000000000014470DOI Listing
February 2019

Relapsing Long-Lasting Garcin Syndrome Revealing Skull Base Diffuse B Cell Lymphoma: The Diagnosis through the "Hartel's Route".

J Neurol Surg B Skull Base 2019 Feb 8;80(1):105-108. Epub 2018 Jun 8.

Department of NESMOS (Neurosciences Mental Health and Sensory Organs), School of Medicine and Psychology, "Sant'Andrea" Hospital, "Sapienza" University of Rome, Rome, Italy.

The Garcin syndrome is a rare condition characterized by multiple unilateral cranial nerve palsy, without neither long-tract involvement nor intracranial hypertension. Non-Hodgkin lymphoma is a systemic malignant disease that localizes in a minority of cases in the central nervous system. We report a case of Garcin syndrome that revealed a diffuse large B cell lymphoma (DLBCL) located in the skull base and in the right kidney. Read More

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http://dx.doi.org/10.1055/s-0038-1657794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365233PMC
February 2019
1 Read

Diffuse large B-cell lymphoma of the central nervous system presenting as "lymphomatosis cerebri" and dementia in elderly man: Case report and review of the literature.

Medicine (Baltimore) 2019 Feb;98(6):e14367

Department of Hematology, Hospital Israelita Albert Einstein.

Rationale: Lymphomatosis cerebri is a rare form of PCNSL, characterized by diffuse infiltration of lymphoma cells in cerebral parenchyma, without mass-formation and mild or no contrast enhancement on magnetic resonance (MR) imaging. There are less than 50 cases described in the literature under the term Lymphomatosis cerebri.

Patient Concerns: A 74-year-old man presented to our service with progressive dementia for 12 months and accelerated cognitive decline within the last two months. Read More

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http://dx.doi.org/10.1097/MD.0000000000014367DOI Listing
February 2019
1 Read

A Rare Case of Primary Central Nervous System Lymphoma in an Adolescent Female Treated with High-Dose Methotrexate and Rituximab-Based Chemoimmunotherapy and Consolidation Whole Brain Radiotherapy.

Pediatr Neurosurg 2019 Jan 22:1-9. Epub 2019 Jan 22.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Primary central nervous system lymphoma (PCNSL) is a rare pediatric brain tumor. A 16-year-old female patient presented to the clinic with complaints of multiple episodes of generalized tonic clonic seizures, nystagmus, and weakness on the left side of the body for 3 weeks. She had similar symptoms, waxing and waning for the last 2 years, responding to corticosteroids. Read More

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http://dx.doi.org/10.1159/000495789DOI Listing
January 2019
3 Reads

Demyelinating lesions behaving like aggressive tumours on advanced MRI techniques.

Neuroradiol J 2019 Jan 22:1971400919826394. Epub 2019 Jan 22.

4 Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, USA.

Tumefactive demyelinating lesions are a rare disorder in which inflammatory demyelination manifests as solitary or multiple focal brain lesions (greater than 2 cm in size), which can be mistaken for glioma, lymphoma, metastasis and in some cases even brain abscess. The symptomatology of tumefactive demyelinating lesions depends on the white matter area involved and includes quickly progressing neurological deterioration of motor, sensory and visual function, praxis, language and mood impairment, as well as seizures. Recognising the key imaging features in a patient with a prior history of demyelination may expedite appropriate management. Read More

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http://dx.doi.org/10.1177/1971400919826394DOI Listing
January 2019
3 Reads

Fluorodeoxyglucose Detected Changes in Brain Metabolism After Chemotherapy in Pediatric Non-Hodgkin Lymphoma.

Pediatr Neurol 2018 Nov 22. Epub 2018 Nov 22.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Nuclear Medicine, Chaim Sheba Medical Center, Tel Hashomer, Israel.

Background: Potential neurocognitive dysfunction after chemotherapy is a worrisome long-term outcome. Our objective was to evaluate the effect on brain metabolism in pediatric patients with non-central nervous system cancer treated with chemotherapy by analyzing brain data from serial whole-body fluorodeoxyglucose positron emission tomography/computed-tomography (FDG-PET/CT) scans taken before and sequentially after therapy.

Methods: Fourteen pediatric patients diagnosed with lymphoma and treated with systemic and prophylactic intrathecal chemotherapy were included. Read More

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http://dx.doi.org/10.1016/j.pediatrneurol.2018.10.019DOI Listing
November 2018
1 Read

Central Nervous System Peripheral T Cell Lymphoma Manifesting as Lymphomatosis Cerebri That Was Misdiagnosed as Neuro-Behçet's Disease: A Case Report.

Case Rep Oncol 2018 Sep-Dec;11(3):806-813. Epub 2018 Nov 29.

Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.

Background: Lymphomatosis cerebri (LC) is a unique form of primary central nerves lymphoma (PCNSL), which presents as diffuse infiltration of lymphoma cells characteristically in the white matter rather than tumor formation. However, the involvement of central nervous system (CNS) is unclear because of the lack of contrast enhancement.

Case Presentation: We treated a 53-year-old woman with LC and brain lesions resembling neuro-Behcet's disease. Read More

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http://dx.doi.org/10.1159/000495033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323408PMC
November 2018
5 Reads

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in limited cutaneous sclerosis: a rare disease combination.

BMJ Case Rep 2019 Jan 7;12(1). Epub 2019 Jan 7.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

A 26-year-old patient of limited cutaneous sclerosis presented to us with insidious-onset posterior fossa symptoms of headache, vomiting, vertigo and gait imbalance, progressing over a period of 3 weeks. A diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids was made by combining the clinical features with radiological evidence showing punctate infiltration of the pons, brainstem and cerebellum. Relevant differentials in the form of neurosarcoid, infections, central nervous system (CNS) lymphoma and Neuro-Behcet's disease were ruled out by history and investigations. Read More

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http://dx.doi.org/10.1136/bcr-2018-226259DOI Listing
January 2019
1 Read

The Radiological Imaging Features of Easily Misdiagnosed Epithelioid Glioblastoma in Seven Patients.

World Neurosurg 2019 Jan 4. Epub 2019 Jan 4.

Department of Pathology, Nanjing Medical University Affiliated Nanjing Brain Hospital, Nanjing, China.

Objective: We review the radiological imaging features and report histopathological findings of 7 adult patients with epithelioid glioblastoma (eGBM), which was a newly revised subtype of glioblastoma.

Methods: Seven adult patients with a diagnosis of eGBM on a brain tissue specimen were retrospectively confirmed by pathology. The tumor magnetic resonance imaging characteristics such as location, number, edema, necrosis, hemorrhage, enhancement, diffusion-weighted image, apparent diffusion coefficient, magnetic resonance spectroscopy, dynamic susceptibility contrast-perfusion-weighted imaging, and histopathological findings were documented. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.128DOI Listing
January 2019
2 Reads

Cultured Cells Isolated from CNS Indolent B-Cell Lymphoma Have Characteristics of Mesenchymal Stem Cells: A Clinical Case and Scientific Research.

Int J Hematol Oncol Stem Cell Res 2018 Jul;12(3):169-174

Laboratory of Clinical Immunology, University Hospital "St. Ivan Rilski", Department of Clinical Laboratory and Clinical Immunology, Medical University of Sofia, Sofia, Bulgaria.

The case report presented here describes the culturing and characterization of mesenchymal stem cells (MSCs) isolated from a primary indolent B-cell lymphoma, located in the CNS of an immunocompetent patient. The presence of such cells in the tumor mass can further elucidate the pathogenesis of the disease and reveal possible future approaches for its treatment. We present a case report of a 61-year-old immunocompetent woman who had an episode of confusion with numbness in the right leg and the right arm, slurred and dysarthric speech and urine incontinence. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305270PMC
July 2018
3 Reads

Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign".

Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.

We herein report the case of a 60-year-old man with a "target sign" in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis. F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. Read More

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http://dx.doi.org/10.2169/internalmedicine.1156-18DOI Listing
December 2018
1 Read

Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.

Neurol Clin Pract 2018 Oct;8(5):379-388

Departments of Neurology (DI, RE, KM, Sucipto, DO, DNL), Microbiology (DCL, A. Karuniawati), Radiology (REY, RM), Internal Medicine (EY, THK), Clinical Pathology (IST, DW), and Parasitology (RW, RA, A. Kurniawan), Cipto Mangunkusumo Hospital-Faculty of Medicine Universitas Indonesia; Eijkman Institute for Molecular Biology (UAJ, DS, KSAM); Eijkman-Oxford Clinical Research Unit (UAJ), Jakarta, Indonesia; Department of Internal Medicine and Radboud Center for Infectious Diseases (AvL, RvC), Radboud University Medical Center, Nijmegen, the Netherlands; TB/HIV Research Center (BA, SD, LC, ARG), Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; and Centre for Tropical Medicine and Global Health (RvC), Nuffield Department of Medicine, University of Oxford, UK.

Background: Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, in low-resource settings.

Methods: From January 2015 to April 2016, we prospectively included all adults with suspected CNS infection in a referral hospital in Jakarta, Indonesia. Systematic screening included HIV testing, CSF examination, and neuroimaging. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276332PMC
October 2018
4 Reads

Incidental Detection of Plasma Cell Neoplasm on 18F-Choline PET/CT Imaging.

Clin Nucl Med 2019 Feb;44(2):140-141

From the Departments of Nuclear Medicine, and.

F-Fluorocholine is a relatively new, extremely versatile radiotracer for detecting proliferative or mitogenic activity. Its diagnostic potential has been explored in cancers of the prostate, liver, esophagus, breast, brain, and lung, as well as lymphoma, sarcoma, melanoma, and parathyroid adenomas. The authors present a case where fluorocholine PET/CT performed for characterizing a space-occupying lesion in the brain revealed intensely tracer-avid skull lesions with intracranial soft tissue component and multiple other skeletal lesions. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9731
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http://dx.doi.org/10.1097/RLU.0000000000002415DOI Listing
February 2019
6 Reads

Myoclonus and hypercalcemia in a dog with poorly differentiated lymphoproliferative neoplasia.

J Vet Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Queen's Veterinary School Hospital, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.

A 1-year, 8-month-old Rhodesian Ridgeback was presented with obtundation, ambulatory tetraparesis, and myoclonus. Initial clinical findings included ionized hypercalcemia with an apparent marked increase in parathyroid hormone, thrombocytopenia, and nonregenerative anemia. Low numbers of circulating atypical cells were noted on blood film evaluation. Read More

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http://dx.doi.org/10.1111/jvim.15398DOI Listing
December 2018
2 Reads

Peripheral nervous system involvement in lymphomas.

J Peripher Nerv Syst 2018 Dec 16. Epub 2018 Dec 16.

Hematology and Clinical Immunology Unit, Department of Medicine, University of Padova, Padova, Italy.

The peripheral nervous system may be involved at any stage in the course of lymphoproliferative diseases. The different underlying mechanisms include neurotoxicity secondary to chemotherapy, direct nerve infiltration (neurolymphomatosis), infections, immune-mediated, paraneoplastic or metabolic processes and nutritional deficiencies. Accordingly, the clinical features are heterogeneous and depend on the localization of the damage (ganglia, roots, plexi, and peripheral nerves) and on the involved structures (myelin, axon, and cell body). Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jns.12295
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http://dx.doi.org/10.1111/jns.12295DOI Listing
December 2018
5 Reads
2.758 Impact Factor

Gadolinium-enhanced imaging of pediatric thoracic lymphoma: is intravenous contrast really necessary?

Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.

Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt/Main, Germany.

Objectives: Increasing awareness of potential side effects from gadolinium-based contrast agents has underlined the need for contrast-free magnetic resonance imaging (MRI). Numerous recent articles evaluated the risk of potential brain deposits, with the result that research is putting the focus more on alternative unenhanced imaging techniques. The aim of this study was to determine the need for contrast media for chest MRI in primary staging and follow-up care of lymphoma. Read More

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http://link.springer.com/10.1007/s00330-018-5859-3
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http://dx.doi.org/10.1007/s00330-018-5859-3DOI Listing
December 2018
10 Reads

[Magnetic resonance imaging features for primary brain lymphoma].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Oct;43(10):1118-1122

Department of Diagnostic Radiology, Hunan Cancer Hospital, Changsha 410013, China.

Objective: To investigate the magnetic resonance imaging (MRI) features for primary brain lymphoma and improve its diagnosis and differential diagnosis.
 Methods: The clinical and MRI data from 14 patients with primary brain lymphoma were retrospectively reviewed.
 Results: Fourteen patients, including 5 males and 9 females, were (55±8) years old. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.10.012DOI Listing
October 2018
1 Read

Prospective phase II clinical trial of autologous haematopoietic stem cell transplant for treatment refractory multiple sclerosis.

J Neurol Neurosurg Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Department of Haematology, St. Vincent's Hospital, Darlinghurst, New South Wales, Australia.

Background: Autologous haematopoietic stem cell transplantation (AHSCT) has been explored as a therapeutic intervention in multiple sclerosis (MS) over the last two decades; however, prospective clinical trials of the most common myeloablative conditioning regimen, BEAM, are limited. Furthermore, patient selection, optimal chemotherapeutic regimen and immunological changes associated with disease response require ongoing exploration. We present the outcomes, safety and immune reconstitution (IR) of patients with active, treatment refractory MS. Read More

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http://dx.doi.org/10.1136/jnnp-2018-319446DOI Listing
December 2018

Ischemic Optic Neuropathy Secondary to Intravascular Lymphoma.

J Neuroophthalmol 2018 Oct 23. Epub 2018 Oct 23.

Departments of Ophthalmology (MD, JW, CO), Neurology (MD, AEM), and Pathology (EL), Weill Cornell Medical College, New York, New York.

Background: To describe a case of optic neuropathy associated with intravascular lymphoma (IVL).

Methods: Case report and review of the literature.

Results: A case of asymmetric binocular vision loss is described, preceded by transient vision loss. Read More

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http://Insights.ovid.com/crossref?an=00041327-900000000-9920
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http://dx.doi.org/10.1097/WNO.0000000000000722DOI Listing
October 2018
11 Reads

Differentiation of Primary Central Nervous System Lymphoma From Glioblastoma: Quantitative Analysis Using Arterial Spin Labeling and Diffusion Tensor Imaging.

World Neurosurg 2018 Nov 29. Epub 2018 Nov 29.

Department of Diagnostic Radiology, Kafr Elsheak Faculty of Medicine, Kafr Elsheak, Egypt.

Objective: Differentiation of primary central nervous system lymphoma (PCNSL) from glioblastoma using arterial spin labeling perfusion and diffusion tensor imaging (DTI).

Methods: We performed a prospective study of 31 patients with a provisional diagnosis of PCNSL and glioblastoma who underwent conventional magnetic resonance imaging, DTI, and arterial spin labeling of the brain. The tumor blood flow (TBF), mean diffusivity (MD) plus fractional anisotropy (FA) of the mass were measured. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183271
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http://dx.doi.org/10.1016/j.wneu.2018.11.155DOI Listing
November 2018
2 Reads
2.417 Impact Factor

Bilateral Proptosis in a Child: A Rare Presentation of Acute Lymphoblastic Leukemia.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):511-513

Division of Pediatric Hematogy/Oncology, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Purpose: Acute lymphoblastic leukemia (ALL), a common hematological malignancy observed in children, typically presents with fever, pallor, easy bruising, hepatosplenomegaly and lymphadenopathy. However, when ALL manifests with unusual signs and the blood counts and peripheral smears are normal, it causes a diagnostic dilemma.

Case Report: We report a 5-year-old boy who presented with bilateral proptosis as the initial manifestation of ALL. Read More

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http://dx.doi.org/10.4103/jovr.jovr_2_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210864PMC
November 2018
2 Reads

Brain invasion by chronic lymphocytic leukemia.

Neuropathology 2019 Feb 25;39(1):54-57. Epub 2018 Nov 25.

Department of Neurosurgery, Dokkyo Medical University, Mibu-machi, Japan.

Brain invasion by chronic lymphocytic leukemia (CLL) is very rare, and only a handful of cases have been reported. We here report a case of 61-year-old woman who had been treated for CLL for 14 years presenting with a progressive mental disturbance. Magnetic resonance imaging (MRI) showed discontinuous ring-enhancing lesions compatible with the "open ring" sign, which was considered a demyelinating disorder, in both the frontal lobes. Read More

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http://dx.doi.org/10.1111/neup.12525DOI Listing
February 2019
1 Read

Comparison between cytospin and liquid-based cytology in cerebrospinal fluid diagnosis of neoplastic diseases: A single institution experience.

Cytopathology 2018 Nov 23. Epub 2018 Nov 23.

Division of Anatomic Pathology and Histology, Foundation "A. Gemelli" University Hospital, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: The current tools available for detecting malignant neoplasms in the cerebrospinal fluid (CSF) are neurological examination, followed by neuroimaging, cytology and molecular techniques. To highlight the role of cytology the diagnosis of metastatic tumours in CSF samples, we present our experience using cytospin and ThinPrep liquid-based cytology.

Methods: A retrospective analysis was conducted using the pathological records of 8181 cytological specimens of CSF, which were diagnosed over a 17-year period. Read More

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http://doi.wiley.com/10.1111/cyt.12659
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http://dx.doi.org/10.1111/cyt.12659DOI Listing
November 2018
9 Reads

Assessment of Primary Brain Lymphoma Using Multimodal Magnetic Resonance Imaging and Proton Magnetic Resonance Spectroscopy.

Asian J Neurosurg 2018 Oct-Dec;13(4):1205-1208

Department of Biophysics, Clinical Neuroscience Laboratory, Faculty of Medicine and Pharmacy, University of Fez, Fez, Morocco.

Objectives: The primary lymphoma of the central nervous system is a cancer rare. The diagnosis of this tumoral entity must be considered as an emergency considering the therapeutical involved. Therefore, we report this entity while reporting diagnostic challenges. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_137_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208237PMC
November 2018
18 Reads

Machine learning applications for the differentiation of primary central nervous system lymphoma from glioblastoma on imaging: a systematic review and meta-analysis.

Neurosurg Focus 2018 Nov;45(5):E5

3Department of Neurosurgery, The University of Texas Medical Branch, Galveston, Texas.

OBJECTIVEGlioblastoma (GBM) and primary central nervous system lymphoma (PCNSL) are common intracranial pathologies encountered by neurosurgeons. They often may have similar radiological findings, making diagnosis difficult without surgical biopsy; however, management is quite different between these two entities. Recently, predictive analytics, including machine learning (ML), have garnered attention for their potential to aid in the diagnostic assessment of a variety of pathologies. Read More

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https://thejns.org/view/journals/neurosurg-focus/45/5/articl
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http://dx.doi.org/10.3171/2018.8.FOCUS18325DOI Listing
November 2018
7 Reads

Machine learning based on multi-parametric magnetic resonance imaging to differentiate glioblastoma multiforme from primary cerebral nervous system lymphoma.

Eur J Radiol 2018 Nov 14;108:147-154. Epub 2018 Sep 14.

Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuoku, Kumamoto, 860-8556, Japan. Electronic address:

Purpose: To evaluate the performance of a machine learning method based on texture features in multi-parametric magnetic resonance imaging (MRI) to differentiate a glioblastoma multiforme (GBM) from a primary cerebral nervous system lymphoma (PCNSL).

Materials And Methods: We included 70 patients who underwent contrast enhanced brain MRI at 3 T with brain tumors diagnosed as GBM (n = 45) and PCNSL (n = 25) in this retrospective study. Twelve histograms and texture parameters were assessed on T2-weighted images (T2WIs), apparent diffusion coefficient maps, relative cerebral blood volume (rCBV) map, and contrast-enhanced T1-weighted images (CE-T1WIs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.017DOI Listing
November 2018
12 Reads

Preoperative localization of the sensorimotor cortex and measurement of tumor perfusion in a single acquisition using ASL technique.

J Clin Neurosci 2019 Jan 1;59:367-371. Epub 2018 Nov 1.

Department of Radiology, Masan University, Changwon, Republic of Korea.

Resting state fMRI (rs-fMRI) using arterial spin labelling (ASL) technique was performed for the preoperative localization of the sensorimotor cortex in a patient with lymphoma and the results were compared to those of task-based (tb) and rs-fMRI studies using blood oxygenation level-dependent (BOLD) sequence. Rs-fMRI using ASL showed similar results in the regions of the sensorimotor network to those of tb- and rs-fMRI fMRI using BOLD. ASL technique has a potential in clinical practice because all of brain perfusion imaging, cerebral blood flow measurement, and rs-fMRI study can be performed at a single acquisition. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868173000
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http://dx.doi.org/10.1016/j.jocn.2018.10.098DOI Listing
January 2019
10 Reads
1.320 Impact Factor

IgG4-related intracranial disease.

Neuroradiol J 2019 Feb 15;32(1):29-35. Epub 2018 Oct 15.

1 Department of Medical Imaging, St Michael's Hospital, Toronto, Canada.

IgG4-related disease (IgG4-RD) is a multi-organ chronic inflammatory process caused by infiltration of IgG4-positive plasma cells in one or more organs. Intracranial involvement has only recently become better recognized. Our case series adds to the growing literature on the varying presentations of intracranial IgG4 by describing the clinical and imaging findings of three patients who presented to our institution with intracranial involvement. Read More

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http://dx.doi.org/10.1177/1971400918806323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327361PMC
February 2019
23 Reads

Myriad of MR imaging phenotypes of primary central nervous system lymphoma in a cohort of immunocompetent Indian patient population.

Indian J Radiol Imaging 2018 Jul-Sep;28(3):296-304

Department of Pathology, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

PCNSL (primary central nervous system lymphoma) is a chemosensitive and radiosensitive tumor, and early diagnosis has a significant impact on management. Unlike many other brain tumors, radical surgical excision of PCNSLs is not indicated because these lesions are highly infiltrative and even partial resection leads to a bad prognosis. The goal of this study is to highlight the unusual radiological presentation of PCNSLs and increase the awareness, familiarity, and global database of our observations that pose a challenge on management. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_23_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176660PMC
October 2018

Intravascular large B-cell lymphoma presenting as multiple stroke: A case report.

Medicine (Baltimore) 2018 Oct;97(41):e12793

Department of Pulmonary and Critical Care Medicine, MedStar Franklin Square Medical Center, Baltimore, MD, USA.

Introduction: Intravascular large B-cell lymphoma (IVLBCL) is an uncommon disease with a poor prognosis if not diagnosed early. It can present with central nervous system (CNS) manifestations. The diagnosis of IVCBCL is difficult to make given its varied clinical manifestations and the lack of a specific diagnostic modality. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810120-0008
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http://dx.doi.org/10.1097/MD.0000000000012793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203540PMC
October 2018
10 Reads

Richter's syndrome of the central nervous system diagnosed concurrently with chronic lymphocytic leukaemia: A case report and literature review.

Medicine (Baltimore) 2018 Oct;97(41):e12701

Flow Cytometry Center, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

Rationale: Central nervous system (CNS) infiltration of Richter's syndrome (RS) is rare and only a few cases were discussed. Of these published cases, either they were accompanied with lymph node involvement or with a history of chronic lymphocytic leukemia (CLL). To our knowledge, this is the first published case of RS of the brain and meninges diagnosed concurrently with CLL in the absence of any evidence of lymphoma outside of the CNS. Read More

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http://dx.doi.org/10.1097/MD.0000000000012701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203471PMC
October 2018
10 Reads
5.723 Impact Factor

CT, conventional, and functional MRI features of skull lymphoma: a series of eight cases in a single institution.

Skeletal Radiol 2018 Oct 11. Epub 2018 Oct 11.

Department of Radiology, First Affiliated Hospital of Fujian Medical University, 20 Cha-Zhong Road, Fuzhou, 350005, Fujian, China.

Objective: With the hypothesis that the combination of CT, conventional, and functional MRI can indicate a possible diagnosis of skull lymphoma, this study aimed to systematically explore CT, conventional, and functional MRI features of this rare entity.

Materials And Methods: This retrospective study included eight patients with pathologically confirmed skull lymphomas. CT and conventional MRI findings, including the location, size, attenuation/signal intensity, cystic/necrosis, hemorrhage, calcification, enhancement, skull change, brain parenchyma edema and adjacent structure invasion, were reviewed. Read More

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http://dx.doi.org/10.1007/s00256-018-3085-3DOI Listing
October 2018
12 Reads

G-Quadruplex-Based Nanoscale Coordination Polymers to Modulate Tumor Hypoxia and Achieve Nuclear-Targeted Drug Delivery for Enhanced Photodynamic Therapy.

Nano Lett 2018 11 10;18(11):6867-6875. Epub 2018 Oct 10.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences , University of Macau , Avenida da Universidade , Taipa , Macau , China.

Photodynamic therapy (PDT) is a light-triggered therapy used to kill cancer cells by producing reactive oxygen species (ROS). Herein, a new kind of DNA nanostructure based on the coordination between calcium ions (Ca) and AS1411 DNA G quadruplexes to form nanoscale coordination polymers (NCPs) is developed via a simple method. Both chlorine e6 (Ce6), a photosensitizer, and hemin, an iron-containing porphyrin, can be inserted into the G-quadruplex structure in the obtained NCPs. Read More

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http://pubs.acs.org/doi/10.1021/acs.nanolett.8b02732
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http://dx.doi.org/10.1021/acs.nanolett.8b02732DOI Listing
November 2018
1 Read
13.592 Impact Factor

Enhanced Anti-lymphoma Activity of CAR19-iNKT Cells Underpinned by Dual CD19 and CD1d Targeting.

Cancer Cell 2018 Oct;34(4):596-610.e11

Centre for Haematology, Department of Medicine, Imperial College London, London, UK. Electronic address:

Chimeric antigen receptor anti-CD19 (CAR19)-T cell immunotherapy-induced clinical remissions in CD19 B cell lymphomas are often short lived. We tested whether CAR19-engineering of the CD1d-restricted invariant natural killer T (iNKT) cells would result in enhanced anti-lymphoma activity. CAR19-iNKT cells co-operatively activated by CD1d- and CAR19-CD19-dependent interactions are more effective than CAR19-T cells against CD1d-expressing lymphomas in vitro and in vivo. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183037
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http://dx.doi.org/10.1016/j.ccell.2018.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6179961PMC
October 2018
9 Reads

Primary Peripheral Gamma Delta T-Cell Lymphoma of the Central Nervous System: Report of a Case Involving the Intramedullary Spinal Cord and Presenting with Myelopathy.

J Pathol Transl Med 2019 Jan 1;53(1):57-61. Epub 2018 Oct 1.

Department of Pathology, Seoul National University Hospital, Seoul, Korea.

Primary central nervous system lymphoma of T-cell origin (T-PCNSL) is rare, and its clinicopathological features remain unclear. Peripheral T-cell lymphoma of γδ T-cell origin is an aggressive lymphoma mainly involving extranodal sites. Here, we report a case of γδ T-PCNSL involving the intramedullary spinal cord and presenting with paraplegia. Read More

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http://www.jpatholtm.org/journal/view.php?doi=10.4132/jptm.2
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http://dx.doi.org/10.4132/jptm.2018.08.21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344803PMC
January 2019
1 Read

A Very Rare Case of Right Insular Lobe Langerhans Cell Histiocytosis (CD1a) Mimicking Glioblastoma Multiforme in a Young Adult.

World Neurosurg 2019 Jan 24;121:4-11. Epub 2018 Sep 24.

Department of Neurosurgery, University General Hospital of Alicante, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Alicante, Spain.

Background: Langerhans cell histiocytosis (LCH) is a multisystemic dendritic cell proliferation that is relatively uncommon in adults. Central nervous system LCH outside the pituitary gland is even more uncommon.

Case Description: We report the case of a 42-year-old man who had complained of right-side hemicranial pain and left arm minor paresis. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.093DOI Listing
January 2019
10 Reads

Random Skin Biopsies Before Brain Biopsy for Intravascular Large B-Cell Lymphoma.

World Neurosurg 2019 Jan 25;121:e364-e369. Epub 2018 Sep 25.

Department of Neurosurgery, University of Tsukuba, Tsukuba, Japan.

Objective: To evaluate effectiveness of random skin biopsies for intravascular large B-cell lymphoma (IVLBCL) with or without central nervous system (CNS) involvement.

Methods: Data from 21 patients with suspected IVLBCL (7 with CNS involvement and 14 without CNS involvement) who underwent single (4 patients), double (1 patient), and random (16 patients) skin biopsies were retrospectively analyzed.

Results: IVLBCL was diagnosed in 16 patients (including 6 with CNS involvement). Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.110DOI Listing
January 2019
3 Reads

An unusual case report of primary vitreoretinal lymphoma.

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):223. Epub 2018 Sep 14.

Centre for Ophthalmology and Vision Sciences, Faculty of Medical and Human Sciences, Medicine and Health, University of Manchester, Manchester, UK.

Background: Primary vitreoretinal lymphoma (PVRL) is a rare ocular condition and its diagnosis remains a challenge. The clinical presentation is variable and it can masquerade as chronic intermediate or posterior uveitis. We report an unusual case of primary central nervous system lymphoma (PCNSL) presenting as migrating retinal lesions with unique shapes. Read More

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http://dx.doi.org/10.1186/s12886-018-0860-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156902PMC
September 2018
1 Read

Adrenal relapse of primary central nervous system diffuse large B-cell lymphoma: A case report.

Medicine (Baltimore) 2018 Sep;97(38):e12482

Department of Pathology, Duke University Medical Center, Durham, NC.

Rationale: Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma with a dismal outcome. Most patients relapse in intracranial sites and <5% of patients relapse in extracranial sites. Here, we present the first case of PCNSL with an adrenal relapse. Read More

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http://dx.doi.org/10.1097/MD.0000000000012482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160128PMC
September 2018
4 Reads

Brain Radiation Necrosis: Current Management With a Focus on Non-small Cell Lung Cancer Patients.

Front Oncol 2018 5;8:336. Epub 2018 Sep 5.

Department of Radiation Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

As the prognosis of metastatic non-small cell lung cancer (NSCLC) patients is constantly improving with advances in systemic therapies (immune checkpoint blockers and new generation of targeted molecular compounds), more attention should be paid to the diagnosis and management of treatments-related long-term secondary effects. Brain metastases (BM) occur frequently in the natural history of NSCLC and stereotactic radiation therapy (SRT) is one of the main efficient local non-invasive therapeutic methods. However, SRT may have some disabling side effects. Read More

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http://dx.doi.org/10.3389/fonc.2018.00336DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134016PMC
September 2018
19 Reads

Radiomics features to distinguish glioblastoma from primary central nervous system lymphoma on multi-parametric MRI.

Neuroradiology 2018 Dec 19;60(12):1297-1305. Epub 2018 Sep 19.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: To determine the feasibility of using high dimensional computer-extracted features, known as radiomics features, in differentiating primary central nervous system lymphoma (PCNSL) from glioblastoma on multi-parametric MR imaging including diffusion-weighted imaging.

Methods: Retrospective evaluation of data was approved by the local ethics committee and informed consent was waived. A total of 143 patients (two independent cohorts for discovery [n = 86; glioblastoma = 49, PCNSL = 37] and validation [n = 57; glioblastoma = 29, PCNSL = 28]) with newly diagnosed glioblastoma and PCNSL were subjected to radiomics analysis using the multi-parametric MRI (contrast-enhanced T1-weighted imaging, T2-weighted imaging, and diffusion-weighted imaging). Read More

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http://dx.doi.org/10.1007/s00234-018-2091-4DOI Listing
December 2018
2 Reads

Primary Vitreoretinal Lymphoma Presenting as a Posterior Capsule Plaque.

Ophthalmic Surg Lasers Imaging Retina 2018 Sep;49(9):732-734

Primary vitreoretinal lymphoma (PVRL) can be a diagnostic challenge and commonly presents as a partially steroid-responsive vitritis or as subretinal cream-colored infiltrates. The authors present a patient with PVRL who initially presented with bilateral vitritis; however, after two non-diagnostic vitrectomy specimens and two unremarkable brain MRIs, she was lost to follow-up. She presented 2. Read More

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http://dx.doi.org/10.3928/23258160-20180831-15DOI Listing
September 2018
1 Read

Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study.

Ann Oncol 2018 Nov;29(11):2214-2222

Division of Medical Oncology, University of Colorado, Aurora, USA.

Background: The phase III ALEX study in patients with treatment-naive advanced anaplastic lymphoma kinase mutation-positive (ALK+) non-small-cell lung cancer (NSCLC) met its primary end point of improved progression-free survival (PFS) with alectinib versus crizotinib. Here, we present detailed central nervous system (CNS) efficacy data from ALEX.

Patients And Methods: Overall, 303 patients aged ≥18 years underwent 1:1 randomization to receive twice-daily doses of alectinib 600 mg or crizotinib 250 mg. Read More

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http://dx.doi.org/10.1093/annonc/mdy405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290889PMC
November 2018
8 Reads

[F]Fludarabine-PET as a promising tool for differentiating CNS lymphoma and glioblastoma: Comparative analysis with [F]FDG in human xenograft models.

Theranostics 2018 10;8(16):4563-4573. Epub 2018 Aug 10.

Normandie Univ, UNICAEN, CEA, CNRS, CHU Caen, ISTCT/LDM-TEP group, GIP Cyceron, Caen, France.

This paper investigated whether positron emission tomography (PET) imaging with [F]fludarabine ([F]FDB) can help to differentiate central nervous system lymphoma (CNSL) from glioblastoma (GBM), which is a crucial issue in the diagnosis and management of patients with these aggressive brain tumors. Multimodal analyses with [F]fluorodeoxyglucose ([F]FDG), magnetic resonance imaging (MRI) and histology have also been considered to address the specificity of [F]FDB for CNSL. Nude rats were implanted with human MC116 lymphoma-cells (n = 9) or U87 glioma-cells (n = 4). Read More

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http://dx.doi.org/10.7150/thno.26754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134939PMC

Primary central nervous system lymphoma with no enhancement initially and no significant progression over a long term: a case report and review of the literature.

Int J Neurosci 2018 Nov 22:1-5. Epub 2018 Nov 22.

b Department of Neurology , the First Affiliated Hospital of Wenzhou Medical University , Wenzhou , China.

Primary central nervous system lymphoma, a rare primary intracranial tumor, is highly malignant and usually associated with poor prognosis. Recent years, owing to the remarkable progress in intervention techniques, survival time reported has been significantly prolonged. Strategies targeting alleviation and remission are primarily depended on the early diagnosis. Read More

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http://dx.doi.org/10.1080/00207454.2018.1523159DOI Listing
November 2018

Multiparametric imaging-based differentiation of lymphoma and glioblastoma: using T1-perfusion, diffusion, and susceptibility-weighted MRI.

Clin Radiol 2018 Nov 7;73(11):986.e7-986.e15. Epub 2018 Sep 7.

Departments of Radiology and Imaging, Fortis Memorial Research Institute, Gurugram, India. Electronic address:

Aim: To compare the diagnostic performance of T1 perfusion magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), and susceptibility-weighted imaging (SWI) for differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM).

Materials And Methods: This retrospective study comprised a cohort of 70 patients with glioblastoma and 30 patients with PCNSL. T1 perfusion MRI-derived rCBV_corr (leakage corrected relative cerebral blood volume), apparent diffusion coefficient (ADC) derived from DWI, and intratumoural susceptibility signals intensity (ITSS) measured on SWI were evaluated in these 100 patients. Read More

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http://dx.doi.org/10.1016/j.crad.2018.07.107DOI Listing
November 2018
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Concomitant subcutaneous intravascular lymphoma lesions in a patient with cardiac diffuse large B-cell lymphoma: is intravascular lymphoma a distinct clinical entity?

Int J Hematol 2018 Dec 8;108(6):637-639. Epub 2018 Sep 8.

Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, 929 Higashi-chou, Kamogawa-shi, Chiba, 296-8602, Japan.

We describe a patient who presented with large cardiac diffuse large B-cell lymphoma (DLBCL) and adrenal masses. The patient also had subcutaneous intravascular lymphoma lesions which were detected by random skin biopsy. Although ambiguous, minimal extravascular location of lymphoma cells is permitted for the diagnosis of intravascular large B-cell lymphoma (IVLBCL) in the WHO definition, a number of rare cases have been reported as having concomitant tumours in other organs, such as the adrenal gland, brain, and penis. Read More

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http://dx.doi.org/10.1007/s12185-018-2532-1DOI Listing
December 2018
3 Reads

Accurate Detection of Tumor Infiltration by C-Methionine Positron Emission Tomography in a Patient with Central Nervous System Intravascular Lymphoma: A Case Report.

Case Rep Oncol 2018 May-Aug;11(2):577-584. Epub 2018 Aug 23.

Jisenkai Brain Imaging Research Center, Aizawa Hospital, Matsumoto, Japan.

Intravascular lymphoma (IVL) is a rare and clinically devastating subtype of extranodal diffuse large B-cell lymphoma with a distinct presentation. Diagnostic difficulty derives from marked variability in clinical presentations and nonspecific laboratory and radiological findings, especially when central nervous system (CNS) symptoms are the only manifestation. Establishing the diagnosis premortem thus remains a major challenge. Read More

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http://dx.doi.org/10.1159/000492465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120372PMC
August 2018
1 Read

Penetrating the evidence of EGFR and ALK tyrosine kinase inhibitors for non-small cell lung cancer brain metastases.

J Oncol Pharm Pract 2018 Sep 4:1078155218796695. Epub 2018 Sep 4.

2 Department of Clinical Health Professions, College of Pharmacy and Health Sciences, St. John's University, New York, USA.

The brain is a common metastatic site in lung cancer. Approximately one-third of patients will develop brain metastases during the course of their disease. Median overall survival has been reported between 3 and 14. Read More

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http://dx.doi.org/10.1177/1078155218796695DOI Listing
September 2018
2 Reads