3,788 results match your criteria Brain Imaging in Lymphoma


Stratifying Brain Tumour Histological Sub-Types: The Application of ATR-FTIR Serum Spectroscopy in Secondary Care.

Cancers (Basel) 2020 Jun 27;12(7). Epub 2020 Jun 27.

WestCHEM, Department of Pure and Applied Chemistry, Technology and Innovation Centre, University of Strathclyde, 99 George St, Glasgow G1 1RD, UK.

Patients living with brain tumours have the highest average years of life lost of any cancer, ultimately reducing average life expectancy by 20 years. Diagnosis depends on brain imaging and most often confirmatory tissue biopsy for histology. The majority of patients experience non-specific symptoms, such as headache, and may be reviewed in primary care on multiple occasions before diagnosis is made. Read More

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http://dx.doi.org/10.3390/cancers12071710DOI Listing

A Surviving Case of Acanthamoeba Granulomatous Amebic Encephalitis in a Hematopoietic Stem Cell Transplant Recipient.

Am J Case Rep 2020 Jun 30;21:e923219. Epub 2020 Jun 30.

Department of Hematology, St. James's Hospital, Dublin, Ireland.

BACKGROUND Acanthamoeba are free-living amoebae with potential to infect immunocompromised hosts. The mortality rate of granulomatous amebic encephalitis (GAE) due to Acanthamoeba exceeds 90% and there are currently no reports of survival of this infection in recipients of hematopoietic stem cell transplant. CASE REPORT We report herein the case of a 32-year-old man presenting to our service with abrupt neurological deterioration and seizures 5 months after allogeneic stem cell transplantation for Hodgkin lymphoma. Read More

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http://dx.doi.org/10.12659/AJCR.923219DOI Listing

Preoperative factors associated with adverse events during awake craniotomy: analysis of 609 consecutive cases.

J Neurosurg 2020 Jun 26:1-9. Epub 2020 Jun 26.

Objective: Awake surgery is becoming more standard and widely practiced for neurosurgical cases, including but not limited to brain tumors. The optimal selection of patients who can tolerate awake surgery remains a challenge. The authors performed an updated cohort study, with particular attention to preoperative clinical and imaging characteristics that may have an impact on the viability of awake craniotomy in individual patients. Read More

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http://dx.doi.org/10.3171/2020.4.JNS20378DOI Listing

Exploiting Cancer's Tactics to Make Cancer a Manageable Chronic Disease.

Cancers (Basel) 2020 Jun 22;12(6). Epub 2020 Jun 22.

Brain Tumor Research Laboratory, Department of Neurological Surgery, University of California, Irvine, CA 92617, USA.

The history of modern oncology started around eighty years ago with the introduction of cytotoxic agents such as nitrogen mustard into the clinic, followed by multi-agent chemotherapy protocols. Early success in radiation therapy in Hodgkin lymphoma gave birth to the introduction of radiation therapy into different cancer treatment protocols. Along with better understanding of cancer biology, we developed drugs targeting cancer-related cellular and genetic aberrancies. Read More

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http://dx.doi.org/10.3390/cancers12061649DOI Listing

Conventional MR and DW imaging findings of cerebellar primary CNS lymphoma: comparison with high-grade glioma.

Sci Rep 2020 Jun 19;10(1):10007. Epub 2020 Jun 19.

Department of Radiology, Shanxi Provincial People's Hospital, Affiliated People's Hospital of Shanxi Medical University, Taiyuan, 030012, China.

Primary central nervous system lymphomas (PCNSLs) and high-grade gliomas (HGGs) arising in the cerebellum is extremely low, making the differential diagnosis difficult or even impossible. The purpose of this study was to define the MR features of cerebellar PCNSL in immunocompetent patients, and to determine whether a combination of conventional MR and DW imaging can assist in the differentiation of PCNSLs and HGGs. Twelve PCNSLs and 15 HGGs confirmed by pathological analysis were retrospectively identified. Read More

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http://dx.doi.org/10.1038/s41598-020-67080-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305207PMC

Sex-Specific Differences in Primary CNS Lymphoma.

Cancers (Basel) 2020 Jun 16;12(6). Epub 2020 Jun 16.

Division of Neuropathology & Neurochemistry, Department of Neurology, Medical University of Vienna, 1090 Vienna, Austria.

Sex-specific differences have been increasingly recognized in many human diseases including brain cancer, namely glioblastoma. Primary CNS lymphoma (PCNSL) is an exceedingly rare type of brain cancer that tends to have a higher incidence and worse outcomes in male patients. Yet, relatively little is known about the reasons that contribute to these observed sex-specific differences. Read More

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http://dx.doi.org/10.3390/cancers12061593DOI Listing

Intravascular Lymphoma with Progressive CNS Hemorrhage and Multiple Dissections.

Case Rep Neurol Med 2020 10;2020:6134830. Epub 2020 Jan 10.

Department of Neurology, University of Utah, 175 N Medical Dr., Salt Lake City, UT 84132, USA.

Introduction: Intravascular lymphoma (IVL) is an uncommon and often fatal disease characterized by intraluminal proliferation of lymphomatous cells within blood vessels. Because of a heterogeneous clinical presentation and lack of sensitive diagnostic protocols, diagnosis of IVL is most often made at autopsy. However, with early diagnosis and appropriate chemotherapy, the prognosis is greatly improved and complete remission is possible. Read More

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http://dx.doi.org/10.1155/2020/6134830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201472PMC
January 2020

Expression of hypoxia-inducible factor 1α, glucose transporter 1, and hexokinase 2 in primary central nervous system lymphoma and the correlation with the biological behaviors.

Brain Behav 2020 Jun 12:e01718. Epub 2020 Jun 12.

Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: It has been indicated that abnormal glucose metabolism mediated by hypoxia-inducible factor 1α (HIF-1α) played an essential role in the development of solid tumor. However, there were rare studies about the role of them in primary central nervous system lymphoma (PCNSL).

Objective: To investigate the protein levels of HIF-1α, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) in PCNSL and whether their levels are associated with prognostic factors. Read More

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http://dx.doi.org/10.1002/brb3.1718DOI Listing

On Point in Primary CNS Lymphoma.

Hematol Oncol 2020 Jun 8. Epub 2020 Jun 8.

Hematology/Oncology, University of California, San Francisco.

Primary CNS lymphoma (PCNSL) is an aggressive brain tumor that represents a significant challenge both to elucidate its biological pathogenesis as well as to develop definitive precision medicines with minimal collateral toxicity. We highlight the key issues in diagnosis and treatment and focus on emerging technologies, current options among consolidation strategies, and biological agents. We anticipate that further development of molecular diagnostics and molecular imaging approaches that elucidate minimal residual disease in brain parenchyma, leptomeninges, intraocular compartments and even bone marrow will greatly impact the delivery and timing of cytotoxic and biological therapies. Read More

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http://dx.doi.org/10.1002/hon.2761DOI Listing
June 2020
3.084 Impact Factor

Post-mortem diagnosis of intravascular large B-cell lymphoma.

J Int Med Res 2020 Jun;48(6):300060520924262

Department of Anatomical, Histological, Forensic and Orthopedic Sciences, Sapienza University of Rome, Rome, Italy.

Intravascular large B-cell lymphoma (IVLBCL) is a rare (<1%), typically aggressive extranodal variant of mature non-Hodgkin B-cell lymphoma. IVLBCL is characterized by malignant lymphoid cells lodged within blood vessels, particularly capillary channels. Herein, we present a case of a 50-year-old man with a history of myeloradiculitis (∼1 year) and paraparesis requiring hospitalization. Read More

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http://dx.doi.org/10.1177/0300060520924262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273565PMC

Maculopathy Associated With Osmotic Blood- Brain Barrier Disruption and Chemotherapy in Patients With Primary CNS Lymphoma.

Ophthalmic Surg Lasers Imaging Retina 2020 05;51(5):S5-S12

Background And Objective: To describe the incidence, characteristics, and risk factors of a pigmentary maculopathy in patients with primary central nervous system (CNS) lymphoma treated with blood-brain barrier disruption (BBBD) therapy.

Patients And Methods: This retrospective chart review included patients with biopsy-proven primary CNS lymphoma treated with or without BBBD therapy who underwent an ophthalmic examination after starting systemic treatment. Clinical data and all available retinal imaging were analyzed. Read More

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http://dx.doi.org/10.3928/23258160-20200108-01DOI Listing

Brain cavernous hemangioma mimicking radiation-induced necrosis in a patient with non-small cell lung cancer.

Thorac Cancer 2020 Jul 29;11(7):2056-2058. Epub 2020 May 29.

Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

In patients with non-small cell lung cancer (NSCLC), stereotactic radiotherapy (SRT) is one of the standard therapies for those suffering with intracranial metastatic NSCLC. Radiation-induced necrosis (RIN) sometimes occurs as the result of the delayed effects of SRT. The magnetic resonance imaging (MRI) of RIN typically shows hypointense and hyperintense lesions on T1- and T2-weighted images, respectively. Read More

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http://dx.doi.org/10.1111/1759-7714.13494DOI Listing
July 2020
1.126 Impact Factor

A diagnostic challenge of primary Central nervous system lymphoma: from the eyes to the brain.

Int J Neurosci 2020 Jun 1:1-7. Epub 2020 Jun 1.

Department of Neurology, the First Medical Center, Chinese PLA General Hospital, Beijing, China.

Being a subtype of primary central nervous system lymphoma (PCNSL), primary vitreoretinal lymphoma (PVRL) is a rare and fatal intraocular malignancy manifesting as blurred vision and floaters, and is usually combined with, or eventually progresses to, central nervous system lesions. The diagnosis of PVRL/PCNSL remains challenging because of the nonspecific clinical features and diagnostic dependency on biopsy. In this paper, we present the clinical, imaging, laboratory, brain biopsy, and vitreous biopsy findings of a 56-year-old immunocompetent woman who presented with blurred vision of the left eye, but which rapidly evolved into lesions of the central nervous system. Read More

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http://dx.doi.org/10.1080/00207454.2020.1773822DOI Listing

Clinicopathological characteristics of primary central nervous system lymphoma with low 18F-fludeoxyglucose uptake on brain positron emission tomography.

Medicine (Baltimore) 2020 May;99(20):e20140

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Primary central nervous system lymphoma (PCNSL) typically shows a strong uptake of F-fludeoxyglucose (FDG) imaged by positron emission tomography (PET). Uncommonly, PCNSL demonstrates a low uptake on FDG PET. We investigated the clinicopathological characteristics of the unusual cases of PCNSL with low FDG uptake. Read More

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http://dx.doi.org/10.1097/MD.0000000000020140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254841PMC

Nasal-Type Extranodal Natural Killer/T Cell Lymphoma with Meningeal Involvement: A Case Report and Literature Review.

Indian J Hematol Blood Transfus 2020 Apr 30;36(2):381-383. Epub 2019 Nov 30.

Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, No. 37, Guoxue Xiang, Wuhou District, Chengdu, 610041 China.

Objectives: We report a case of a 26-year-old man diagnosed with nasal-type extranodal natural killer/T cell lymphoma (ENKTL) extending beyond the nasal cavity. Complete response was achieved after therapy, followed by rapid metastasis to the meningeal nerve fibres. The overall survival (OS) of the patient was 15 months. Read More

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http://dx.doi.org/10.1007/s12288-019-01234-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229061PMC

Orbital Magnetic Resonance Imaging May Contribute to the Diagnosis of Optic Nerve Lymphoma.

Front Neurol 2020 28;11:301. Epub 2020 Apr 28.

Department of Ophthalmology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

Optic nerve lymphoma can present a diagnostic challenge because of its confusing clinical features and the difficulty of obtaining lesion tissue for biopsy. The objective of this study was to find some flags of lymphomatous infiltration of optic nerves. We report two cases of optic nerve lymphoma and conduct a literature review to determine whether a common diagnostic characteristic can be identified. Read More

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http://dx.doi.org/10.3389/fneur.2020.00301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198801PMC

Use of FDG-PET/CT for systemic assessment of suspected primary central nervous system lymphoma: a LOC study.

J Neurooncol 2020 Jun 13;148(2):343-352. Epub 2020 May 13.

Médecine Nucléaire, Sorbonne Université, AP-HP, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France.

Introduction: Primary Central Nervous System Lymphoma (PCNSL) is a rare disease with different therapeutic implications than systemic lymphoma. In this study, we evaluated whole-body FDG-PET/CT for pre-chemotherapy imaging of suspected PCNSL.

Methods: One hundred and thirty consecutive immunocompetent patients were retrospectively included. Read More

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http://dx.doi.org/10.1007/s11060-020-03525-5DOI Listing

Precision of preoperative diagnosis in patients with brain tumor - A prospective study based on "top three list" of differential diagnosis for 1061 patients.

Surg Neurol Int 2020 28;11:55. Epub 2020 Mar 28.

Department of Neurosurgery, Kagoshima University, Sakuragaoka, Kagoshima, Japan.

Background: Accurate diagnosis of brain tumor is crucial for adequate surgical strategy. Our institution follows a comprehensive preoperative evaluation based on clinical and imaging information.

Methods: To assess the precision of preoperative diagnosis, we compared the "top three list" of differential diagnosis (the first, second, and third diagnoses according to the WHO 2007 classification including grading) of 1061 brain tumors, prospectively and consecutively registered in preoperative case conferences from 2010 to the end of 2017, with postoperative pathology reports. Read More

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http://dx.doi.org/10.25259/SNI_5_2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193216PMC

Case Report of Immuno-Oncotherapy (IO) Provoked Encephalitis Mimicking Brain Metastasis in a Patient with History of Traumatic Brain Injury.

World Neurosurg 2020 Apr 30;139:483-487. Epub 2020 Apr 30.

Neuroscience Institute, Geisinger Medical Center, Danville, Pennsylvania, USA; Cancer Institute, Geisinger Medical Center, Danville, Pennsylvania, USA. Electronic address:

Background: Immuno-oncotherapy (IO) has revolutionized systemic cancer care but remains experimental in brain tumors. IO treatment risks multiorgan autoimmune inflammatory responses that limit its use. The central nervous system (CNS) is an immune-specialized compartment with restricted cellular access, thus fewer cases are reported for immune-mediated encephalitis. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.177DOI Listing

Chidamide based combination regimen for treatment of monomorphic epitheliotropic intestinal T cell lymphoma following radical operation: Two case reports.

World J Clin Cases 2020 Apr;8(7):1278-1286

Department of Hematology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510655, Guangdong Province, China.

Background: Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) is a rare extra-nodal T-cell lymphoma that has uniformly aggressive features with a poor prognosis. No standardized treatment protocols have been established. Previous experience has demonstrated favorable outcomes with combination chemotherapy followed by autologous hematopoietic stem cell transplant. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i7.1278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176621PMC

CXCR4-targeted positron emission tomography imaging of central nervous system B-cell lymphoma.

J Nucl Med 2020 Apr 24. Epub 2020 Apr 24.

Hematology, Oncology, and Tumor Immunology (Campus Benjamin Franklin), Charite - Universitaetsmedizin Berlin, Berlin, Germany.

C-X-C chemokine receptor 4 is a transmembrane chemokine receptor involved in growth, survival, and dissemination of cancer, including aggressive B-cell lymphoma. Magnetic resonance imaging (MRI) is the standard imaging technology for central nervous system involvement of B-cell lymphoma and provides high sensitivity but moderate specificity. Therefore, novel molecular and functional imaging strategies are urgently required. Read More

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http://dx.doi.org/10.2967/jnumed.120.241703DOI Listing

Maintenance of multi-domain neurocognitive functions in patients with newly-diagnosed primary CNS lymphoma after primary cranial radiotherapy combined with methotrexate-based chemotherapy: A preliminary case-series study.

Appl Neuropsychol Adult 2020 Apr 17:1-10. Epub 2020 Apr 17.

Department of Psychology, National Chengchi University, Taipei, Taiwan.

Conventional treatment for treating primary central nervous system lymphoma (PCNSL) has consisted of either whole-brain radiotherapy (WBRT) or methotrexate (MTX)-based combined modality therapy. However, delayed cognitive sequelae have emerged as a significant debilitating complication in PCNSL patients. A prospective observational case-series study with prospective assessments of neurocognitive functions (NCFs), neuroimaging, and activities of daily living in newly-diagnosed PCNSL patients was undertaken. Read More

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http://dx.doi.org/10.1080/23279095.2020.1749630DOI Listing

Parkinsonism as a late presentation of lymphomatosis cerebri following high-dose chemotherapy with autologous stem cell transplantation for primary central nervous system lymphoma.

J Neurol 2020 Apr 15. Epub 2020 Apr 15.

Department of Medicine, Division of Hematology and Oncology, Mayo Clinic, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA.

Primary central nervous system lymphoma is an aggressive form of non-Hodgkin lymphoma arising in the eyes, meninges, spinal cord, or brain. Treatment of primary CNS lymphoma with a combination of high-dose chemotherapy and autologous stem cell transplantation has been shown to have high rates of remission which is frequently sustained for multiple years. Recurrence of primary CNS lymphoma generally presents with one or multiple contrast enhancing lesions on MRI. Read More

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http://dx.doi.org/10.1007/s00415-020-09819-yDOI Listing

Subclinical Cardiac Dysfunction in Childhood Cancer Survivors on 10-Years Follow-Up Correlates With Cumulative Anthracycline Dose and Is Best Detected by Cardiopulmonary Exercise Testing, Circulating Serum Biomarker, Speckle Tracking Echocardiography, and Tissue Doppler Imaging.

Front Pediatr 2020 31;8:123. Epub 2020 Mar 31.

Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Center Munich, Technical University Munich, Munich, Germany.

Survivors of childhood cancer are at risk for anthracycline- and/or radiotherapy-induced cardiotoxicity. The aim of this study was to assess clinical, laboratory, and imaging parameters of subclinical cardiovascular disease in childhood cancer survivors. Patients underwent cardiopulmonary exercise test (CPET), laboratory testing, transthoracic echocardiography (TTE) with tissue doppler imaging (TDI) and speckle tracking. Read More

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http://dx.doi.org/10.3389/fped.2020.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136405PMC

Is there a need for pediatric PET/CT camera?

Authors:
Ismet Sarikaya

J Nucl Med Technol 2020 Apr 10. Epub 2020 Apr 10.

Kuwait University, Faculty of Medicine, Mubarak Al-Kabeer Hospital, Kuwait.

Positron emission tomography (PET) imaging is commonly used in adult patients. Its use in pediatric patients is limited but indicated in certain cancers such as lymphoma, sarcoma, neuroblastoma and central nervous system tumors (1). The main limitation of PET imaging is its relatively limited spatial resolution in detecting small lesions which is mainly due to non-collinearity of the 511 keV annihilation photons, positron range, detector scatter, and parallax error (2-5). Read More

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http://dx.doi.org/10.2967/jnmt.119.240713DOI Listing

Multiple Cerebral Hemorrhages With Microbleeds in Intravascular Large B-Cell Lymphoma.

J Stroke Cerebrovasc Dis 2020 Jun 2;29(6):104798. Epub 2020 Apr 2.

Kobe City Medical Center General Hospital, Department of Neurology, Kobe, Hyogo, Japan.

This is an extremely rare reported case of intravascular large B-cell lymphoma (IVLBCL) presenting with acute hemorrhages and numerous microbleeds. An 80-year-old man presented with consciousness disturbances after convulsion. Computed tomography revealed multiple hemorrhages, and susceptibility-weighted imaging (SWI) demonstrated numerous microbleeds. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2020.104798DOI Listing

Primary Central Nervous System Lymphoma in a Patient on Adalimumab Therapy for Chronic Plaque Psoriasis.

World Neurosurg 2020 Apr 2;139:260-263. Epub 2020 Apr 2.

Neurosurgery Department, American Hospital, Dubai, United Arab Emirates. Electronic address:

Background: Adalimumab (Humira) is a recombinant human monoclonal antibody against tumor necrosis factor alpha, which works by blocking the interaction of tumor necrosis factor alpha with its cell-surface receptors, thereby limiting the progression of inflammatory pathways. Its use is approved for several autoimmune conditions, including chronic plaque psoriasis, for which it has been prescribed as a first-line biologic treatment. Increased risks of malignancy, particularly nonmelanoma skin cancer and non-central nervous system lymphomas, have been reported with use of this drug; however, there have been no reports of central nervous system lymphomas. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.03.155DOI Listing

Missing the Target.

N Engl J Med 2020 04;382(14):1353-1359

From the Departments of Medicine (C.I., F.M.M., A.L.M., J.L.) and Neurology (H.V.), Brigham and Women's Hospital, and the Departments of Medicine (C.I., F.M.M., A.L.M., J.L.) and Neurology (H.V.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcps1901669DOI Listing

An Autopsy Case of Varicella Zoster Virus Encephalitis with Multiple Brain Lesions.

Intern Med 2020 Apr 2. Epub 2020 Apr 2.

Department of Neurology, International University of Health and Welfare Hospital, Japan.

VZV encephalitis in the absence of vasculopathy may rarely occur in association with herpes zoster. We herein report the case of a 67-year-old woman with non-Hodgkin' s lymphoma undergoing chemotherapy who presented with an acute alteration in consciousness. Magnetic resonance imaging of the brain revealed multiple and nonspecific lesions of hyperintensity with mild edema in the cortex and subcortex. Read More

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http://dx.doi.org/10.2169/internalmedicine.3417-19DOI Listing

Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study.

Front Psychiatry 2020 11;11:201. Epub 2020 Mar 11.

Toulouse NeuroImaging Center, Université de Toulouse, Inserm, UPS, Toulouse, France.

The cancer experience may be marked by repeat stressors and/or traumas. The aim of our study was to assess traumatic events in a group of patients diagnosed with lymphoma and to determine which of these contribute to the development of Post-Traumatic Stress Disorder/PTSD. Two weeks after receiving a diagnosis of lymphoma, patients were referred for an assessment of peritraumatic distress (using the Peritraumatic Distress Inventory/PDI) and peritraumatic dissociation (using the Peritraumatic Dissociative Experiences Questionnaire/PDEQ). Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078238PMC

Primary Central Nervous System Lymphoma Presenting As Chronic Subdural Hematoma: Case Report and Review of the Literature.

Cureus 2020 Feb 19;12(2):e7043. Epub 2020 Feb 19.

Neurological Surgery, University of Miami Miller School of Medicine, Miami, USA.

Primary central nervous system lymphoma (PCNSL) rarely manifests in immunocompetent patients. In such cases, these lesions may mimic more common intracranial bleeding or tumors. We present the case of an elderly patient who presented with a presumed chronic subdural hematoma (SDH); upon surgical intervention, an occult mass was discovered with no evidence of associated hematoma. Read More

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http://dx.doi.org/10.7759/cureus.7043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083252PMC
February 2020

Spectrum of Posttransplant Lymphoproliferations in NSG Mice and Their Association With EBV Infection After Engraftment of Pediatric Solid Tumors.

Vet Pathol 2020 05 23;57(3):445-456. Epub 2020 Mar 23.

Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Pediatric patients receiving solid organ transplants may develop lymphoproliferative diseases, including graft-versus-host disease (GvHD) and posttransplant lymphoproliferative diseases (PTLDs). We characterized lesions in 11 clinically ill NOD.Cg-/SzJ (NSG) mice that received pediatric-patient-derived solid tumors (PDXs) and developed immunodeficiency-associated lymphoproliferations comparable to GvHD and PTLDs over a period of 46 to 283 days after implantation. Read More

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http://dx.doi.org/10.1177/0300985820913265DOI Listing

A case of primary central nervous system lymphoma presenting as a shunt complication.

Br J Neurosurg 2020 Mar 12:1-4. Epub 2020 Mar 12.

Department of Neurological Surgery, University of Miami Miller School of Medicine, Lois Pope Life Center, Miami, FL, USA.

The authors describe an 82-year-old female with a right frontal ventriculoperitoneal (VP) shunt for long-standing normal pressure hydrocephalus (NPH) who presented with worsening incontinence and gait instability. She was found to have right lateral ventricle collapse around the shunt catheter and subsequently underwent shunt revision, which failed to improve her symptoms. Magnetic resonance imaging (MRI) was obtained on postoperative day two, which demonstrated a ventricular lesion. Read More

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http://dx.doi.org/10.1080/02688697.2020.1735300DOI Listing

[A Case of Primary Central Nervous System Lymphoma that Developed during the Treatment of Castration-Resistant Prostate Cancer].

Hinyokika Kiyo 2020 Feb;66(2):49-52

The Department of Urology, Osaka International Cancer Institute.

A 64-year-old man was diagnosed with metastatic prostate cancer (cT3bN0M1b) and treated with combined androgen blockade. After two years and three months, he developed castration-resistant prostate cancer. Multiple lung metastases appeared after the administration of five courses of docetaxel and four courses of cabazitaxel therapy. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_2_49DOI Listing
February 2020

Early Detection of Secondary Central Nervous System Lymphoma on PET/CT.

Clin Nucl Med 2020 May;45(5):e254-e257

Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, Singapore.

We present a case of secondary central nervous system relapse of lymphoma detected initially on PET/CT without corresponding findings on MRI. A 60-year-old lymphoma patient demonstrated an FDG-avid focus in left cerebellar hemisphere on restaging PET/CT. MRI brain showed no corresponding abnormality, and expectant management ensued. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002991DOI Listing

[Primary leptomeningeal lymphoma with oculomotor paralysis as the initial presentation].

Rinsho Ketsueki 2020 ;61(2):116-121

Department of Diagnostic Pathology, Asahi General Hospital.

An 85-year-old man presented with right eye ptosis and visual abnormalities. Due to a lack of abnormal findings on plain magnetic resonance imaging (MRI) and laboratory examination, prednisolone therapy was initiated, and ocular myasthenia gravis and ocular symptoms subjectively improved. However, anorexia and conscious disorder appeared during the same period, and he was hospitalized for scrutiny. Read More

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http://dx.doi.org/10.11406/rinketsu.61.116DOI Listing

18F-FDG PET/CT demonstrated symmetric FDG uptake in internal capsule in a diffuse large B cell lymphoma patient with false interpretation on multiparametric brain MRI.

Eur J Nucl Med Mol Imaging 2020 Mar 4. Epub 2020 Mar 4.

Department of Nuclear Medicine, Beijing Friendship Hospital Affiliated to Capital Medical University, China No. 95, Yong-An Road, Xi Cheng District, Beijing, 100050, People's Republic of China.

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http://dx.doi.org/10.1007/s00259-020-04737-7DOI Listing
March 2020
5.383 Impact Factor

[Case of isolated neurosarcoidosis requiring differentiation from tuberculous meningitis].

Rinsho Shinkeigaku 2020 Mar 26;60(3):213-218. Epub 2020 Feb 26.

Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center.

A 62-year-old woman was transported to our hospital for management of generalized clonic seizures. Cerebrospinal fluid examination showed an increased monocyte-dominant cell count, high protein concentration, and low glucose concentration that was 17% of the plasma glucose concentration. Contrast-enhanced cranial magnetic resonance imaging revealed diffuse leptomeningeal enhancement with multiple nodular lesions. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001387DOI Listing

[Intravascular large B-cell lymphoma with multiple intracranial hemorrhages diagnosed by brain biopsy].

Rinsho Shinkeigaku 2020 Mar 26;60(3):206-212. Epub 2020 Feb 26.

Department of Neurology, National Hospital Organization, Sendai Medical Center.

Central nervous system intravascular lymphoma sometimes includes multiple lesions mimicking cerebral infarction. Herein, we report our experience with a case of intravascular large B-cell lymphoma (IVLBCL) with multiple hemorrhages. A 53-year-old woman was admitted to our hospital with clonic convulsions of the left upper limb. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001373DOI Listing

Hidden disseminated extracutaneous AIDS-related Kaposi sarcoma.

IDCases 2020 10;19:e00716. Epub 2020 Feb 10.

Center for Infectious Diseases and Infection Control, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

A 68-year-old man with past medical history of multiple cerebral infarctions presented to our hospital with subacute paresis. His vital signs on presentation were normal, and his physical examination, other than his neurological findings, was unremarkable. Neurological examinations suggested cerebellar ataxia. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7030992PMC
February 2020

Man With Double Vision and a Swollen Testicle.

Ann Emerg Med 2020 03;75(3):369-399

Department of Emergency Medicine, University of Iowa, Iowa City, IA.

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http://dx.doi.org/10.1016/j.annemergmed.2019.09.011DOI Listing

Lymphoma, a great imitator in neurology.

J Clin Neurosci 2020 Mar 18;73:308-310. Epub 2020 Feb 18.

Department of Neurology, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy VIC 3065, Australia.

The title "great imitator" refers to conditions which can cause varied manifestations and mimic many diseases. Lymphoma is worthy of this title. We describe three cases of lymphoma in which lymphoma mimicked other diseases causing neurological dysfunction, specifically sarcoidosis, vasculitis and infection respectively. Read More

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http://dx.doi.org/10.1016/j.jocn.2020.02.001DOI Listing

Atypical radiological findings of primary central nervous system lymphoma.

Neuroradiology 2020 Jun 20;62(6):669-676. Epub 2020 Feb 20.

Department of Neuroradiology, National Neuroscience Institute, Singapore, Singapore.

Purpose: Primary central nervous system lymphoma (PCNSL) presenting with atypical radiological findings often leads to delayed diagnosis. We aim to characterize the radiological features and apparent diffusion coefficient (ADC) values of PCNSL with atypical neuroimaging presentation in our local population.

Methods: We retrospectively reviewed all patients with histological diagnosis of CNS lymphoma at our tertiary center from 2005 to 2016. Read More

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http://dx.doi.org/10.1007/s00234-020-02377-0DOI Listing

Volume de-escalation in radiation therapy: state of the art and new perspectives.

J Cancer Res Clin Oncol 2020 Apr 18;146(4):909-924. Epub 2020 Feb 18.

Radiotherapy Oncology Department, General Regional Hospital "F. Miulli", Acquaviva delle Fonti, Bari, Italy.

Purpose: New RT techniques and data emerging from follow-up for several tumor sites suggest that treatment volume de-escalation may permit to minimize therapy-related side effects and/or obtain better clinical outcomes. Here, we summarize the main evidence about volume de-escalation in RT.

Method: The relevant literature from PubMed was reviewed in this article. Read More

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http://dx.doi.org/10.1007/s00432-020-03152-7DOI Listing

Cardiac Myxoma with Cerebral Metastases and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: A Case Report and Review.

J Neurol Surg Rep 2020 Jan 11;81(1):e1-e6. Epub 2020 Feb 11.

Department of Neurosurgery, Baptist Health South Florida, Miami, Florida, United States.

 Cardiac myxomas, the most common primary cardiac tumors, are generally benign neoplasms. Primary cardiac lymphoma is a rare cardiac malignancy with a very poor prognosis. Here we present a case of a cardiac myxoma with cerebral metastases and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) arising within the cerebral metastases. Read More

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http://dx.doi.org/10.1055/s-0039-3399570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012640PMC
January 2020

Factors Linked to Prognosis in Patients with Leptomeningeal Metastasis Diagnosed by Spinal Magnetic Resonance Imaging.

Spine Surg Relat Res 2020 1;4(1):64-68. Epub 2019 Nov 1.

Division of Orthopedic Surgery, Chiba Cancer Center, Chiba, Japan.

Introduction: Leptomeningeal metastasis (LM) is known to demonstrate a very poor prognosis. The purpose of this study was to evaluate the prognostic factors in LM cases diagnosed by spinal magnetic resonance imaging (MRI).

Methods: We retrospectively analyzed 19 patients with LM detected by spinal MRI between 2010 and 2017. Read More

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http://dx.doi.org/10.22603/ssrr.2019-0064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002071PMC
November 2019

[A Case of Primary Central Nervous System Lymphomatoid Granulomatosis that was Completely Ameliorated by Corticosteroid Treatment].

Brain Nerve 2020 Feb;72(2):159-165

Department of Neurosurgery, Kindai University School of Medicine.

Lymphomatoid granulomatosis (LYG) is an angiocentric, angiodestructive lymphoreticular proliferative disease that usually affects the lungs but it has been speculated to also effect the central nervous system (CNS). However, unique primary LYG of the CNS has rarely been reported in the literature. Herein, we describe a clinical case of a 37-year-old female patient with grade 1 primary CNS-LYG having a good prognosis owing to corticosteroid treatment. Read More

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http://dx.doi.org/10.11477/mf.1416201496DOI Listing
February 2020

Development of Primary Diffuse Large B-Cell Lymphoma Around an Internal Fixation Implant After Lumbar Fusion Surgery: A Case Report and Review of the Literature.

World Neurosurg 2020 May 5;137:140-145. Epub 2020 Feb 5.

Department of Spinal Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Diffuse large B-cell lymphoma (DLBCL) is the most commonly diagnosed primary non-Hodgkin lymphoma of the spine and can induce spinal compression. Reports of lymphoma arising in bone adjacent to metallic prostheses are increasing. However, to our knowledge, DLBCL arising from a scar after lumbar fusion surgery has not been reported previously. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.227DOI Listing

Episodic Visual Distortions and Stroke-Like Symptoms in a 56-Year-Old Man With Intravascular Lymphoma.

J Neuroophthalmol 2020 Jun;40(2):265-270

Division of Neuro-Ophthalmology (BKC, VPD, KAAD, DMC), Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; and Departments of Neurology (BKC), Pathology (MML), and Radiology (HRK), Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts.

A healthy 56-year-old man presented with vision changes and left upper extremity motor and sensory changes. MRI of the brain without contrast was significant for multifocal areas of restricted diffusion in multiple vascular territories. Neuro-Ophthalmic evaluation revealed an inferonasal visual field defect in the left eye, thickened choroid on optical coherence tomography, and bilateral delayed arteriovenous and choroidal filling on fluorescein angiogram. Read More

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http://dx.doi.org/10.1097/WNO.0000000000000900DOI Listing