3,993 results match your criteria Brain Imaging in Lymphoma


Spontaneous anterior cervicothoracic spinal epidural hematoma extending to clivus in SARS-CoV-2 infection.

Surg Neurol Int 2021 26;12:181. Epub 2021 Apr 26.

Department of Neurosurgery, Highly Specialized Hospital and of National Importance "Garibaldi", Catania, Italy.

Background: The treatment of spontaneous spinal epidural hematomas (SSEHs), depending on the lesion size and myeloradicular involvement, can be surgical or conservative. Here, we present a 55-year-old patient who sustained a SSEH several months following a systemic SARS-CoV-2 infection.

Case Description: A 55-year-old immunocompromised female (i. Read More

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Monitoring and Managing Lorlatinib Adverse Events in the Portuguese Clinical Setting: A Position Paper.

Drug Saf 2021 Jun 3. Epub 2021 Jun 3.

Centro Hospitalar Universitário de São João, Porto, Portugal.

Rearrangements in the anaplastic lymphoma kinase (ALK) and proto-oncogene tyrosine-protein kinase ROS (ROS1) genes characterise two distinct molecular subsets of non-small cell lung cancer (NSCLC) tumours. Lorlatinib is a third-generation ALK/ROS1 tyrosine kinase inhibitor (TKI) shown to have systemic and intracranial activity in treatment-naive patients and in those who progressed on first- and second-generation TKIs. Despite being generally well tolerated, lorlatinib has a unique and challenging safety profile that includes hyperlipidaemia and central and peripheral nervous system adverse events (AEs). Read More

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Successful Management of a Patient with Refractory Primary Central Nervous System Lymphoma by Zanubrutinib.

Onco Targets Ther 2021 24;14:3367-3372. Epub 2021 May 24.

Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, People's Republic of China.

Primary central nervous system lymphoma (PCNSL) is a rare subtype of extranodal non-Hodgkin lymphoma, and the most frequent histological type is diffuse large B-cell lymphoma (DLBCL). Bruton's tyrosine kinase inhibitor (BTKi) has shown clinical activity in DLBCL. We herein report a 53-year-old man who presented with binocular diplopia, gait instability, dizziness and bucking. Read More

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Primary vitreoretinal lymphoma: A diagnostic and management challenge.

Blood 2021 May 25. Epub 2021 May 25.

Université de Paris, UMR 144 CNRS, France.

Primary vitreoretinal lymphoma (PVRL) is a rare form of primary central nervous system lymphoma (PCNSL) arising in the intraocular compartment without brain involvement. Despite its apparent indolent clinical course, PVRL can cause permanent vision loss and CNS relapse, the major cause of death in PVRL patients. The pathophysiology of PVRL is unknown. Read More

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Primary hypothalamic lymphoma with clinical findings mimicking pituitary apoplexy: a case report.

J Med Case Rep 2021 May 25;15(1):293. Epub 2021 May 25.

Department of Endocrinology and Metabolism, Kocaeli University College of Medicine, Kocaeli, 41000, Turkey.

Background: Primary central nervous system lymphoma (PCNSL) is a rare but well-known extra-nodal lymphoma, which usually presents with non-Hodgkin B-cell lymphomas. PCNSL is generally located around the ventricle and is often detected as multiple lesions. It is rarely seen in the area of the hypothalamus. Read More

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Primary intramedullary spinal-cord lymphoma (PISCL): a rare entity with a challenging diagnosis.

BMJ Case Rep 2021 May 19;14(5). Epub 2021 May 19.

Neurology, Centro Hospitalar e Universitário de Coimbra EPE, Coimbra, Coimbra, Portugal.

Primary intramedullary spinal-cord lymphoma (PISCL) is a rare cause of myelopathy and constitutes only 1% of central nervous system lymphomas. Delay to diagnosis is common due to its rarity, its similarity to other causes of myelopathy and the difficulties in obtaining pathological diagnosis. We report a case of PISCL and discuss the challenges faced on diagnosis, namely the impact of corticosteroids on histological findings, the usefulness of MRI, positron-emission tomography/CT (PET/CT) and repeated lumbar punctures. Read More

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An atypical case of neurotoxoplasmosis in immunocompetent patient.

Radiol Case Rep 2021 Jul 1;16(7):1766-1769. Epub 2021 May 1.

Hospital Beneficência Portuguesa de São Paulo, Department of Neurology, rua Mestro Cradim, 769, 01323001 São Paulo, SP, Brazil.

Toxoplasmosis is an infection caused by , an intracellular protozoan that is often associated with immunocompromised patients and is rare in immunocompetent. A 60-year-old man was admitted with a history of 2 days of headache and right-sided weakness. There was no history of fever, surgeries, or any other comorbid illness. Read More

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The role of surgical resection in primary central nervous system lymphoma: a single-center retrospective analysis of 70 patients.

BMC Neurol 2021 May 11;21(1):190. Epub 2021 May 11.

Department of Neurosurgery, Tongji hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Jiefang Avenue, Wuhan, 430030, Hubei, China.

Background: The aim of this study was to evaluate the effect of surgical resection and stereotactic biopsy on the complication rate, progression-free survival (PFS) and overall survival (OS) of 70 patients diagnosed at a single institution with primary central nervous system lymphoma (PCNSL) and to explore the predictors of selection for resection and the prognostic factors of PCNSL.

Methods: A retrospective analysis was performed of 70 patients with PCNSL that was diagnosed by surgical resection or stereotactic brain biopsy in our department from January 2013 to May 2019. We divided the patients into two groups: a resection group (n = 28) and a stereotactic biopsy group (n = 42). Read More

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Natural killer T-cell lymphoma causing bilateral recurrent recalcitrant dacryocystitis.

Orbit 2021 May 11:1-5. Epub 2021 May 11.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

A 35-year-old female with a history of chronic extensive rhinosinusitis, previously treated twice with functional endoscopic sinus surgery, presented with recurrent dacryocystitis despite prior dacryocystorhinostomy. Histopathological specimens taken at the most recent sinus surgery demonstrated a lymphocytic inflammatory reaction without evidence of angiodestruction or necrosis. Flow cytometry was normal. Read More

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Reduction of immunosuppression combined with whole-brain radiotherapy and concurrent systemic rituximab is an effective yet toxic treatment of primary central nervous system post-transplant lymphoproliferative disorder (pCNS-PTLD): 14 cases from the prospective German PTLD registry.

Ann Hematol 2021 May 11. Epub 2021 May 11.

Department of Haematology and Oncology, DIAKO Ev. Diakonie-Krankenhaus Bremen, Gröpelinger Heerstr. 406-408, 28239, Bremen, Germany.

Post-transplant lymphoproliferative disorders (PTLD) exclusively affecting the central nervous system-primary CNS-PTLD (pCNS-PTLD)-are rare. There is no standard therapy, and previous case series have included heterogeneous treatment approaches. We performed a retrospective, multi-centre analysis of 14 patients with pCNS-PTLD after solid organ transplantation (SOT) treated in the prospective German PTLD registry with reduction of immunosuppression (RI), whole-brain radiotherapy (WBRT), and concurrent systemic rituximab between 2001 and 2018. Read More

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Primary diffuse large B-cell lymphoma of the CNS, with a "Lymphomatosis cerebri" pattern.

Autops Case Rep 2021 Apr 20;11:e2021250. Epub 2021 Apr 20.

Post Graduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India.

We describe an unusual case of lymphomatosis cerebri in a middle-aged lady presenting with rapid-onset dementia. The lymphomatous infiltrate, instead of forming mass lesions, percolated throughout the brain parenchyma, which is often missed on a stereotactic biopsy and hence warrants caution and awareness about this entity. The nonspecific symptoms at presentation and a variable picture at imaging make this entity diagnostically challenging. Read More

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Prognostic value of [F]FDG PET/CT in patients with CNS lymphoma receiving ibrutinib-based therapies.

Eur J Nucl Med Mol Imaging 2021 May 8. Epub 2021 May 8.

Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: Current clinical and imaging tools remain suboptimal for predicting treatment response and prognosis in CNS lymphomas. We investigated the prognostic value of baseline [F]FDG PET in patients with CNS lymphoma receiving ibrutinib-based treatments.

Methods: Fifty-three patients enrolled in a prospective clinical trial and underwent brain PET before receiving single-agent ibrutinib or ibrutinib in combination with methotrexate with or without rituximab. Read More

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Gastrointestinal and oncologic outcomes of pediatric gastrointestinal lymphoma following upfront resection or biopsy of bowel masses.

Pediatr Surg Int 2021 May 8. Epub 2021 May 8.

Department of Paediatric Surgery, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore, 229899, Singapore.

Purpose: Complete upfront resection of pediatric gastrointestinal lymphomas is recommended over biopsy whenever feasible, but either approach may have adverse sequelae. We sought to compare gastrointestinal and oncological outcomes of pediatric gastrointestinal lymphomas who underwent attempted upfront resection or biopsy of the presenting bowel mass.

Methods: We retrospectively reviewed charts of children with gastrointestinal lymphomas treated on LMB89 and LMB96 protocols from 2000 to 2019 who underwent upfront gastrointestinal surgery, and compared resection and biopsy groups. Read More

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Characteristics of central nervous system progression in non-small cell lung cancer treated with crizotinib or alectinib.

Cancer Rep (Hoboken) 2021 May 7:e1414. Epub 2021 May 7.

Department of Thoracic Medical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: Most patients treated with anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors for ALK-positive non-small cell lung cancer (NSCLC) develop resistance, leading to metastasis, with progression to the central nervous system (CNS) being a primary concern. Although alectinib has better CNS penetration than crizotinib, patients treated with alectinib also develop CNS progression. CNS metastases more likely occurs during crizotinib treatment due to less blood-brain barrier (BBB) penetration capability than alectinib. Read More

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Central nervous system intravascular lymphoma leading to rapidly progressive dementia.

Proc (Bayl Univ Med Cent) 2021 Jan 11;34(3):373-375. Epub 2021 Jan 11.

Department of Medicine, Baylor College of Medicine, Houston, Texas.

Intravascular lymphoma is an uncommon subtype of B-cell lymphoma with neoplastic cells limited to the lumen of small blood vessels. We report a case of a 52-year-old man who presented with constitutional symptoms and rapidly progressive dementia. He was found to have diffuse leptomeningeal and faint parenchymal enhancement on magnetic resonance imaging and was subsequently diagnosed with intravascular lymphoma following a brain biopsy. Read More

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January 2021

Diagnostic Performance of Pretreatment 18F-Fluorodeoxyglucose Positron Emission Tomography With or Without Computed Tomography in Patients With Primary Central Nervous System Lymphoma: Updated Systematic Review and Diagnostic Test Accuracy Meta-analyses.

Clin Lymphoma Myeloma Leuk 2021 Apr 3. Epub 2021 Apr 3.

Department of Nuclear Medicine & Molecular Imaging, ACTREC/TMH, Tata Memorial Centre, Homi Bhabha National Institute (HBNI), Mumbai, India.

This review aimed to assess diagnostic performance of 18F-flouro-deoxy-glucose positron emission tomography (FDG-PET) with or without computed tomography (CT) scan in primary central nervous system lymphoma (PCNSL). Eligible studies reporting diagnostic accuracy of pretreatment FDG-PET(CT) scan in immunocompetent adults with PCNSL were identified through systematic literature search. Data on diagnostic performance from individual studies was summarized in a 2 × 2 table classifying patients as true positives, true negatives, false positives, and false negatives using histopathologic diagnosis as reference standard. Read More

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Lymphoma involving the brain and adrenals: A chicken and egg situation.

J Pak Med Assoc 2021 Feb;71(2(B)):778

Department of Nuclear Medicine, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan.

Primary cerebellar diffuse large B-cell lymphoma (DLBCL) is a rare entity, which manifests with neurological symptoms. It is aggressive in nature with high rate of recurrence and short survival period. It commonly presents with local invasion and rarely spreads outside the central nervous system. Read More

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February 2021

Clinical Applications of Magnetic Resonance Spectroscopy in Brain Tumors: From Diagnosis to Treatment.

Radiol Clin North Am 2021 May 23;59(3):349-362. Epub 2021 Mar 23.

Radiology and Imaging Sciences, Emory University, 1364 Clifton Road Northeast BG20, Atlanta, GA 30322, USA.

Magnetic resonance spectroscopy (MRS) is a valuable tool for imaging brain tumors, primarily as an adjunct to conventional imaging and clinical presentation. MRS is useful in initial diagnosis of brain tumors, helping differentiate tumors from possible mimics such as metastatic disease, lymphoma, demyelination, and infection, as well as in the subsequent follow-up of patients after resection and chemoradiation. Unfortunately, the spectroscopic appearance of many pathologies can overlap, and ultimately follow-up or biopsy may be required to make a definitive diagnosis. Read More

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Age- and Intravenous Methotrexate-Associated Leukoencephalopathy and Its Neurological Impact in Pediatric Patients with Lymphoblastic Leukemia.

Cancers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Department of Pediatric Oncology, KU Leuven, 3000 Leuven, Belgium.

Methotrexate (MTX) is associated with leukoencephalopathy (LE) in children treated for lymphoblastic leukemia/lymphoma (ALL/LBL). However, large-scale studies with systematic MR acquisition and quantitative volumetric lesion information remain limited. Hence, the prevalence of lesion burdens and the potential risk factors of LE in this population are still inconclusive. Read More

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Histological verification of the treatment effect of tirabrutinib for relapsed/refractory primary central nervous system lymphoma.

Exp Hematol Oncol 2021 Apr 26;10(1):29. Epub 2021 Apr 26.

Department of Neurosurgery, Osaka International Cancer Institute, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Tirabrutinib (ONO/GS-4059; Ono Pharmaceutical) is a newly developed drug that selectively and irreversibly inhibits Bruton's tyrosine kinase (BTK) and has been approved in Japan for treating relapsed/refractory primary central nervous system lymphoma (PCNSL). However, its therapeutic effect is yet to be verified at the pathological level in human patients. A 64-year-old patient with recurrent PCNSL enrolled in the phase I/II clinical trial of tirabrutinib, a second-generation BTK inhibitor designed for treating relapsed/refractory PCNSL. Read More

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Assessment of Brain Metastasis at Diagnosis in Non-Small-Cell Lung Cancer: A Prospective Observational Study From North India.

JCO Glob Oncol 2021 Apr;7:593-601

Department of Radiation Oncology, Dr B.R.A.I.R.C.H., All India Institute of Medical Sciences, New Delhi, India.

Purpose: The incidence of symptomatic brain metastasis at diagnosis in non-small-cell lung cancer (NSCLC) is 5%-10%, and up to 40% develop during the disease course. There is a paucity of data supporting the role of brain imaging at diagnosis in asymptomatic cases particularly from resource-constraint settings. Here, we present our experience of mandatory baseline brain imaging with contrast-enhanced computed tomography (CECT) scans of all patients with NSCLC. Read More

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Immune checkpoint inhibition in classical hodgkin lymphoma.

Expert Rev Anticancer Ther 2021 Apr 27:1-14. Epub 2021 Apr 27.

Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

: Hodgkin lymphoma (HL) accounts for 10% of lymphoma cases every year. HL is often curable by conventional chemotherapy and radiotherapy. However, in case of relapsed or refractory HL (r/r HL) after autologous hematopoietic stem cell transplantation (ASCT), few treatment options are currently available. Read More

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Clinical and radiological aspects of bilateral temporal abnormalities: pictorial essay.

Radiol Bras 2021 Mar-Apr;54(2):115-122

Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brazil.

The temporal lobes are vulnerable to several diseases, including infectious, immune-mediated, degenerative, vascular, metabolic, and neoplastic processes. Therefore, lesions in the temporal lobes can pose a diagnostic challenge for the radiologist. The temporal lobes are connected by structures such as the anterior commissure, corpus callosum, and hippocampal commissure. Read More

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Posterior reversible encephalopathy syndrome in a patient with Richter's syndrome on combination DA-R-EPOCH chemotherapy regimen: a case report.

J Med Case Rep 2021 Apr 12;15(1):161. Epub 2021 Apr 12.

Department of Internal Medicine, AMITA Health Saint Francis Hospital, 355 Ridge Ave, Evanston, IL, 60202, USA.

Background: Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiologic entity characterized by headaches, altered mental status, seizures, visual loss, and a characteristic imaging pattern in brain magnetic resonance images. The exact etiology and pathogenesis of this condition are not yet fully elucidated.

Case Presentation: A 72-year-old White man presented with 2 weeks of low-grade fever and chills, night sweats, fatigue, dysphagia, and new-onset rapidly increasing cervical lymphadenopathy. Read More

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[Rapidly progressive dementia associated with leukoencephalopathy: A case report of lymphomatosis cerebri].

Medwave 2021 Mar 26;21(2):e8138. Epub 2021 Mar 26.

Hospital Nacional Edgardo Rebagliati Martins, Essalud, Lima, Perú. ORCID: 0000-0002-6791-1074.

Introduction: Lymphomatosis cerebri is a rare form of primary central nervous system lymphoma characterized by an atypical clinical presentation and neuroimaging, with a poor short-term prognosis.

Case Report: A 51-year-old woman began with clinical manifestations characterized by rapidly progressing cognitive impairment associated with a behavioral disorder, myoclonus, and gait disturbance. The brain magnetic resonance image showed extensive signaling in the bilateral periventricular white matter. Read More

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Relevance of Brain MRI in Patients with Uveitis: Retrospective Cohort on 402 Patients.

Ocul Immunol Inflamm 2021 Apr 7:1-7. Epub 2021 Apr 7.

Department of Internal Medicine, Hôpital de la Croix Rousse, Hospices Civils de Lyon, Lyon, France.

: To assess the diagnostic value of brain magnetic resonance imaging (bMRI) for the etiological diagnosis of uveitis and to establish predictive factors associated with its advantageous use.: Retrospective study on all patients with uveitis who were referred to our tertiary hospital and who underwent a bMRI between 2003 and 2018.: bMRI was contributive in 19 out of 402 cases (5%), among patients with a contributive bMRI, 68% had neurological signs. Read More

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Treatment of secondary central nervous system involvement in systemic aggressive B cell lymphoma using R-MIADD chemotherapy: a single-center study.

Chin Neurosurg J 2021 Apr 2;7(1):20. Epub 2021 Apr 2.

Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Secondary central nervous system lymphoma (SCNSL) is defined as lymphoma involvement within the central nervous system (CNS) that originated elsewhere, or a CNS relapse of systemic lymphoma. Prognosis of SCNSL is poor and the most appropriate treatment is still undetermined.

Methods: We conducted a retrospective study to assess the feasibility of an R-MIADD (rituximab, high-dose methotrexate, ifosfamide, cytarabine, liposomal formulation of doxorubicin, and dexamethasone) regimen for SCNSL patients. Read More

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Primary Central Nervous System Lymphoma Mimicking Longitudinally Extensive Transverse Myelitis.

Neurohospitalist 2021 Apr 16;11(2):170-174. Epub 2020 Oct 16.

Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA.

Primary central nervous system lymphoma (PCNSL) is an uncommon variant of extra-nodal non-Hodgkin's lymphoma. Three regions can be involved in PCNSL: the brain, the spine, or the vitreus and retina. Spinal PCNSL is rare. Read More

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Radiotherapy as Salvage Treatment in Intraocular Lymphoma: A Case Report.

Case Rep Oncol 2021 Jan-Apr;14(1):184-189. Epub 2021 Mar 1.

Radiotherapy Department, Instituto Português de Oncologia Francisco Gentil E.P.E, Lisbon, Portugal.

A 67-year-old previously healthy woman presented with progressive visual impairment including bitemporal hemianopsia. A brain magnetic resonance imaging revealed a contrast-enhancing mass in the optic chiasm, spreading along the left optic tract. The patient underwent a transcranial biopsy of the left optical tract that yielded a diagnosis of diffuse large B-cell lymphoma. Read More

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[Tumefactive demyelinating lesion (TDL)].

No Shinkei Geka 2021 Mar;49(2):376-382

Department of Neurology, Brain Research Institute, Niigata University.

Tumefactive demyelinating lesion(TDL)is defined as a large lesion, size >2 cm, mass effect, perilesional edema and/or ring enhancement. TDL could occur in multiple sclerosis(MS), neuromyelitis optica spectrum disorder(NMOSD), acute disseminated encephalomyelitis(ADEM)or other immunological diseases. Non-invasive methods including MR imaging and assay of several autoantibodies(e. Read More

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