4,223 results match your criteria Brain Imaging in Lymphoma


Atypical Posterior Reversible Encephalopathy Syndrome in Intraorbital Lymphoma after Tumor Biopsy: An Illustrative Case.

J Neurol Surg Rep 2022 Apr 24;83(2):e50-e53. Epub 2022 Jun 24.

Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

 A 63-year-old male presented with visual loss and left eye proptosis. Magnetic resonance imaging revealed a left orbital tumor, measuring 1.4 cm × 0. Read More

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Neurofibromatosis from Head to Toe: What the Radiologist Needs to Know.

Radiographics 2022 Jun 24:210235. Epub 2022 Jun 24.

From the Department of Radiology (M.X.W., C.T.J., K.M.E.) and Department of Lymphoma and Myeloma (S.K.), University of Texas MD Anderson Cancer Center, Pickens Academic Tower, 1400 Pressler St, Houston, TX 77030-4009; Department of Radiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio (J.R.D.); Department of Radiology, Stanford University, Stanford, Calif (J.G.); Department of Radiology (A.H.) and Faculty of Medicine (M.M.), Alexandria University, Alexandria, Egypt; and Department of Radiology, Mayo Clinic Arizona, Phoenix/Scottsdale, Ariz (P.M.P.).

Neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2) are autosomal dominant inherited neurocutaneous disorders or phakomatoses secondary to mutations in the and tumor suppressor genes, respectively. Although they share a common name, NF1 and NF2 are distinct disorders with a wide range of multisystem manifestations that include benign and malignant tumors. Imaging plays an essential role in diagnosis, surveillance, and management of individuals with NF1 and NF2. Read More

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Clinical Features, Diagnosis, and Treatment of Primary Intraventricular Lymphoma: Insights From a Monocentric Case Series.

Front Neurol 2022 6;13:920505. Epub 2022 Jun 6.

Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: Primary ventricular lymphoma (PVL) is an extremely rare and commonly misdiagnosed disease. Previous studies were predominantly case reports, and literature regarding the diagnosis and treatment of PVL is limited. Therefore, this study aimed to evaluate the characteristics of patients with PVL. Read More

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Durable remission with Bruton's tyrosine kinase inhibitor therapy in a patient with leptomeningeal disease secondary to relapsed mantle cell lymphoma.

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Hematology and Oncology, The University of Texas McGovern Medical School, Houston, Texas, USA.

Mantle cell lymphoma (MCL) is an incurable B cell non-Hodgkin's lymphoma with a variable clinical course. Central nervous system (CNS) involvement is a rare and dreaded complication in MCL. We report a case of leptomeningeal relapse of MCL that was successfully treated with a single-agent Bruton's tyrosine kinase inhibitor. Read More

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Posterior Reversible Encephalopathy Syndrome Secondary to R-CHOP Chemotherapy Regimen.

Cureus 2022 May 14;14(5):e24988. Epub 2022 May 14.

Clinical Hematology, Mohammed V Military Teaching Hospital, Mohammed V University, Rabat, MAR.

Chemotherapy-induced posterior reversible encephalopathy (PRES) syndrome is a rare event. Its recurrence after reusing the incriminated molecules remains unpredictable. We report the case of a 58-year-old female patient being followed for a diffuse large B-cell lymphoma treated with rituximab, cyclophosphamide, hydroxydaunorubicin hydrochloride (doxorubicin hydrochloride), vincristine (Oncovin), and prednisone (R-CHOP) regimen. Read More

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The forgotten appearance of metastatic melanoma in the small bowel.

Cancer Imaging 2022 Jun 14;22(1):27. Epub 2022 Jun 14.

Department of Radiology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Background: Melanoma is the most aggressive form of skin cancer, with a tendency to metastasise to any organ of the human body. While the most common body organs affected include liver, lungs, brain and soft tissues, spread to the gastrointestinal tract is not uncommon. In the bowel, it can present with a multitude of imaging appearances, more rarely as an aneurysmal dilatation. Read More

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Intracranial extraosseous dural-based Ewing's sarcoma with fluid-haematocrit levels: imaging findings of a rare tumour.

BMJ Case Rep 2022 Jun 14;15(6). Epub 2022 Jun 14.

Radiodiagnosis, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India.

Extraosseous dural-based primary Ewing's sarcoma of the central nervous system is a rare tumour posing a diagnostic challenge. On cross-sectional radiological imaging, the lesion has an extra-axial location with heterogeneous appearance. These lesions are usually multicystic with internal haemorrhage causing fluid-haematocrit levels. Read More

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Cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma undergoing standard chemotherapy: a longitudinal feasibility study.

Support Care Cancer 2022 Jun 14. Epub 2022 Jun 14.

Department of Nursing, Faculty of Medicine, Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.

Purpose: Cancer-related cognitive impairment (CRCI) is a recognised adverse consequence of cancer and its treatment. This study assessed the feasibility of collecting longitudinal data on cognition in patients with newly diagnosed, aggressive lymphoma undergoing standard therapy with curative intent via self-report, neuropsychological assessment, peripheral markers of inflammation, and neuroimaging. An exploration and description of patterns of cancer-related cognitive impairment over the course of treatment and recovery was also undertaken and will be reported separately. Read More

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A Systematic Review of the Current Status and Quality of Radiomics for Glioma Differential Diagnosis.

Cancers (Basel) 2022 May 31;14(11). Epub 2022 May 31.

IRCCS Synlab SDN, 80143 Naples, Italy.

Radiomics is a promising tool that may increase the value of imaging in differential diagnosis (DDx) of glioma. However, implementation in clinical practice is still distant and concerns have been raised regarding the methodological quality of radiomic studies. Therefore, we aimed to systematically review the current status of radiomic studies concerning glioma DDx, also using the radiomics quality score (RQS) to assess the quality of the methodology used in each study. Read More

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PET-CT in Clinical Adult Oncology-V. Head and Neck and Neuro Oncology.

Cancers (Basel) 2022 May 31;14(11). Epub 2022 May 31.

Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT 84132, USA.

PET-CT is an advanced imaging modality with many oncologic applications, including staging, assessment of response to therapy, restaging, and longitudinal surveillance for recurrence. The goal of this series of six review articles is to provide practical information to providers and imaging professionals regarding the best use of PET-CT for specific oncologic indications, and the potential pitfalls and nuances that characterize these applications. In addition, key tumor-specific clinical information and representative PET-CT images are provided to outline the role that PET-CT plays in the management of oncology patients. Read More

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Editorial for "Radiomic-Based MRI for Classification of Solitary Brain Metastasis Subtypes From Primary Lymphoma of the Central Nervous System".

J Magn Reson Imaging 2022 Jun 3. Epub 2022 Jun 3.

Department of Radiological Sciences, University of California, Irvine, California, USA.

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Radiomic-Based MRI for Classification of Solitary Brain Metastases Subtypes From Primary Lymphoma of the Central Nervous System.

J Magn Reson Imaging 2022 Jun 2. Epub 2022 Jun 2.

Department of Radiology, Xiangya Hospital, Central South University, Changsha, China.

Background: Differential diagnosis of brain metastases subtype and primary central nervous system lymphoma (PCNSL) is necessary for treatment decisions. The application of machine learning facilitates the classification of brain tumors, but prior investigations into primary lymphoma and brain metastases subtype classification have been limited.

Purpose: To develop a machine-learning model to classify PCNSL, brain metastases with primary lung and non-lung origin. Read More

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Methotrexate-induced Leukoencephalopathy: A Rare but Life-threatening Toxicity.

J Coll Physicians Surg Pak 2022 Apr;32(4):S44-S46

Clinical Haematology, Armed Forces Bone Marrow Transplant Centre (AFBMTC), Rawalpindi, Pakistan.

Methotrexate (MTX), an anti-metabolite, is part of various chemotherapy regimens to treat acute lymphoblastic leukemia (ALL) and certain non-Hodgkin's lymphomas (NHLs). It is the major drug used in central nervous system (CNS) prophylaxis. Besides, its common hepatic, pulmonary, and hematologic toxicities, it has been implicated in the development of toxic leukoencephalopathy. Read More

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Radiophysiomics: Brain Tumors Classification by Machine Learning and Physiological MRI Data.

Cancers (Basel) 2022 May 10;14(10). Epub 2022 May 10.

Department of Scientific Computing, Florida State University, 400 Dirac Science Library, Tallahassee, FL 32306-4120, USA.

The precise initial characterization of contrast-enhancing brain tumors has significant consequences for clinical outcomes. Various novel neuroimaging methods have been developed to increase the specificity of conventional magnetic resonance imaging (cMRI) but also the increased complexity of data analysis. Artificial intelligence offers new options to manage this challenge in clinical settings. Read More

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Neurolymphomatosis in follicular lymphoma: an autopsy case report.

Neuropathology 2022 May 23. Epub 2022 May 23.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

Neurolymphomatosis is a neurological manifestation of lymphoma that involves the cranial or spinal peripheral nerves, nerve roots, and plexus with direct invasion of neoplastic cells. Neurolymphomatosis is rare among patients with low-grade lymphoma. We report an autopsied case of neurolymphomatosis that arose from follicular lymphoma. Read More

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Sex-Based Differences in Functional Brain Activity During Working Memory in Survivors of Pediatric Acute Lymphoblastic Leukemia.

JNCI Cancer Spectr 2022 03;6(2)

Department of Epidemiology and Cancer Control, St. Jude's Children's Research Hospital, Memphis, TN, USA.

Background: Long-term survivors of pediatric acute lymphoblastic leukemia are at elevated risk for neurocognitive deficits and corresponding brain dysfunction. This study examined sex-based differences in functional neuroimaging outcomes in acute lymphoblastic leukemia survivors treated with chemotherapy alone.

Methods: Functional magnetic resonance imaging (fMRI) and neurocognitive testing were obtained in 123 survivors (46% male; median [min-max] age = 14. Read More

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Flaccid Brachial Monoplegia As Initial Presentation in a Patient With Progressive Multifocal Leukoencephalopathy.

Cureus 2022 Apr 17;14(4):e24211. Epub 2022 Apr 17.

Neurological Surgery, Norton Neuroscience Institute, Norton Healthcare, Louisville, USA.

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by activation of John Cunningham virus (JCV) replication in the setting of impaired cellular immunity. A positive polymerase chain reaction (PCR) assay for JCV DNA in the cerebrospinal fluid (CSF) in conjunction with clinical findings and neuroimaging are diagnostic of PML. A false negative JCV PCR in the CSF may occur, necessitating PML confirmation by brain biopsy. Read More

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Central nervous system neurotoxicity associated with nelarabine in T-cell acute lymphoblastic leukemia.

J Oncol Pharm Pract 2022 May 20:10781552221102591. Epub 2022 May 20.

Department of Radiology, 63988Cukurova University School of Medicine, Adana, Turkey.

Introduction: Nelarabine, a prodrug of arabinosylguanine has lineage-specific toxicity for T lymphoblasts and is used to treat refractory or relapsed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma patients. The most commonly observed adverse effects associated with nelarabine are mainly hematological, i.e. Read More

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Neuroimaging findings in immune effector cell associated neurotoxicity syndrome after chimeric antigen receptor T-cell therapy.

Leuk Lymphoma 2022 May 14:1-11. Epub 2022 May 14.

Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Australia.

Chimeric antigen receptor T-cell (CAR-T) therapy is a promising immunotherapy approved for hematological malignancies. Despite its effectiveness, clinically significant rates of toxicity, including immune effector cell associated neurotoxicity syndrome (ICANS), limit its widespread use. In certain contexts, ICANS may occur in up to one-third of patients using commercially available CAR-T therapies. Read More

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High intratumoral susceptibility signal grade on susceptibility-weighted imaging: a risk factor for hemorrhage after stereotactic biopsy.

J Neurosurg 2022 May 13:1-8. Epub 2022 May 13.

1Department of Neurosurgery, and.

Objective: This study aimed to examine the association of preoperative intratumoral susceptibility signal (ITSS) grade with hemorrhage after stereotactic biopsy (STB).

Methods: The authors retrospectively reviewed 66 patients who underwent STB in their institution. Preoperative factors including age, sex, platelet count, prothrombin time-international normalized ratio, activated thromboplastin time, antiplatelet agent use, history of diabetes mellitus and hypertension, target location, anesthesia type, and ITSS data were recorded. Read More

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Physiological instability is linked to mortality in primary central nervous system lymphoma: A case-control fMRI study.

Hum Brain Mapp 2022 May 11. Epub 2022 May 11.

Oulu Functional Neuroimaging, University of Oulu/Oulu University Hospital, Oulu, Finland.

Primary central nervous system lymphoma (PCNSL) is an aggressive brain disease where lymphocytes invade along perivascular spaces of arteries and veins. The invasion markedly changes (peri)vascular structures but its effect on physiological brain pulsations has not been previously studied. Using physiological magnetic resonance encephalography (MREG ) scanning, this study aims to quantify the extent to which (peri)vascular PCNSL involvement alters the stability of physiological brain pulsations mediated by cerebral vasculature. Read More

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A Rare Presentation of Primary Central Nervous System Lymphoma in an Immunocompetent Patient.

Cureus 2022 Apr 5;14(4):e23858. Epub 2022 Apr 5.

Internal Medicine, Methodist Health System, Dallas, USA.

Primary central nervous system lymphoma (PCNSL) is a rare non-Hodgkin's lymphoma (NHL) that can develop in the brain, spinal cord, leptomeninges, and vitreoretinal space. The majority of cases are diffuse large B-cell lymphomas. Risk factors include immune dysfunction, prior Epstein-Barr viral infection, HIV, and a family history of non-Hodgkin's lymphoma. Read More

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An Update on Neurosurgical Management of Primary CNS Lymphoma in Immunocompetent Patients.

Front Oncol 2022 20;12:884724. Epub 2022 Apr 20.

Department of Neurosurgery, Medical University of Innsbruck, Innsbruck, Austria.

Primary central nervous system lymphomas (PCNSL) are rare CNS tumors that harbor a conspicuously longer diagnostic delay compared to other malignant brain tumors. The gold standard for diagnosis is stereotactic biopsy to acquire tissue for histopathological analysis and therefore neurosurgery plays a central role when reducing the diagnostic period is mandated. However, histopathological diagnosis could be complicated if the patient was preoperatively exposed to corticosteroids. Read More

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Isolated CNS relapse of medullary aggressive high-grade B-cell lymphoma on F-FDG-PET/CT.

Eur J Hybrid Imaging 2022 May 3;6(1). Epub 2022 May 3.

Radiology Department, Mater Misericordiae University Hospital, Eccles Street,, Dublin 7, Ireland.

This is a case of high-risk, aggressive, high-grade medullary B-cell lymphoma presenting with new onset of neurological dysfunction following initial complete response to the standard chemoimmunotherapy. A whole-body re-staging PET using fluorodeoxyglucose (F-FDG) integrated with computed tomography (FDG-PET/CT) performed with clinical suspicion of arachnoiditis, eloquently demonstrated unequivocal multifocal FDG uptake by the spinal cord without evidence of systemic recurrence, leading to a clinical diagnosis of secondary CNS lymphoma, which is a rare complication of DLBCL with ominous prognosis. Four cycles of Modified-MATRIX protocol resulted in a halt in fulminant course of the disease and the patient experienced slight reversal of the neurological deficits, although not deemed clinically fit for a repeat FDG-PET/CT due to his poor general well-being. Read More

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Radiation exposure by medical X-ray applications.

Ger Med Sci 2022 31;20:Doc06. Epub 2022 Mar 31.

University of Duisburg-Essen, Institute for Health Care Management and Research, Essen, Germany.

Radioactive material and ionising radiation play a central role in medical diagnostics and therapy. The benefit of ionising radiation is opposed by the risk of irreparable damage of the human organism. This risk, especially for developing malign neoplasms, has particularly been investigated in the population surviving the atomic bombing of Hiroshima and Nagasaki, but also increasingly in persons with occupational or medical exposure to ionising radiation. Read More

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Rhombencephalomyelitis due to possible paraneoplastic syndrome associated with Hodgkin's lymphoma.

BMJ Case Rep 2022 Apr 21;15(4). Epub 2022 Apr 21.

Neuroscience, Meitra Hospital, Kozhikode, Kerala, India.

We report a unique case of rhombencephalomyelitis with unclear aetiology, diagnosed with Hodgkin's lymphoma (HL) on follow-up.A woman in her 50s was presented with gait difficulty, dysarthria, left Horner's syndrome and left trigeminal sensory loss. MRI of the brain revealed an enhanced T2 and fluid attenuated inversion recovery hyperintense lesion at the cervico-medullary junction, suggesting rhombencephalomyelitis. Read More

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Primary CNS lymphoma of the corpus callosum: presentation and neurocognitive outcomes.

J Neurooncol 2022 May 21;158(1):99-109. Epub 2022 Apr 21.

Neurologie 2, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, Sorbonne Université, IHU, ICM, Paris, France.

Introduction: The corpus callosum (CC) is frequently involved in primary central nervous system lymphomas (PCNSLs). In this cohort study, we described the neurocognition of patients with PCNSL-CC and its posttherapeutic evolution.

Methods: Immunocompetent patients with PCNSL-CC were identified retrospectively at the Pitié-Salpêtrière Hospital. Read More

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Enhancement pattern of demyelination-mimicking cerebral B-cell lymphoma.

Eur J Neurol 2022 Apr 20. Epub 2022 Apr 20.

Department of Neurosurgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background And Purpose: Central nervous system (CNS) B-cell lymphoma-mimicking demyelinating diseases creates a diagnostic dilemma. This study aimed to determine the specific magnetic resonance imaging (MRI) features of CNS B-cell lymphoma to facilitate the early identification of the disease.

Methods: We retrospectively reviewed the brain MRI of biopsy-confirmed CNS B-cell lymphoma patients. Read More

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PRES-like leukoencephalopathy presenting with status epilepticus associated with Brentuximab Vedotin treatment.

Acta Biomed 2022 03 21;92(S4):e2021416. Epub 2022 Mar 21.

Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Italy.

Posterior Reversible Encephalopathy Syndrome (PRES) is characterized by acute neurological symptoms with typical imaging features, primarily in the territories of the brain supplied by the posterior circulation, probably due to vasogenic edema. Both clinical and imaging features are generally reversible. We report a 13-year-old girl affected by Nodular Sclerosis Classical Hodgkin Lymphoma stage IIIB into complete remission, with a recurrence and autologous bone-marrow transplantation, who has been treated with an anti-CD30 monoclonal antibody, brentuximab-vedotin. Read More

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A CT-based radiomics model to predict subsequent brain metastasis in patients with ALK-rearranged non-small cell lung cancer undergoing crizotinib treatment.

Thorac Cancer 2022 Jun 18;13(11):1558-1569. Epub 2022 Apr 18.

State Key Laboratory of Oncology in South China, Guangzhou, China.

Background: Brain metastasis (BM) comprises the most common reason for crizotinib failure in patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). We hypothesize that its occurrence could be predicted by a computed tomography (CT)-based radiomics model, therefore, allowing for selection of enriched patient populations for prevention therapies.

Methods: A total of 75 eligible patients were enrolled from Sun Yat-sen University Cancer Center between June 2014 and September 2019. Read More

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