462 results match your criteria Brain Imaging in Hemangioblastoma

Differentiation of hemangioblastoma from brain metastasis using MR amide proton transfer imaging.

J Neuroimaging 2022 Jun 22. Epub 2022 Jun 22.

Department of Radiology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background And Purpose: Differentiation between hemangioblastoma and brain metastasis remains a challenge in neuroradiology using conventional MRI. Amide proton transfer (APT) imaging can provide unique molecular information. This study aimed to evaluate the usefulness of APT imaging in differentiating hemangioblastomas from brain metastases and compare APT imaging with diffusion-weighted imaging and dynamic susceptibility contrast perfusion-weighted imaging. Read More

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Favorable management of symptomatic cerebellar hemangioblastoma presenting with obstructive hydrocephalus during pregnancy: A case report and literature review.

Surg Neurol Int 2022 29;13:174. Epub 2022 Apr 29.

Department of Neurosurgery, Fukuoka University, Fukuoka, Japan.

Background: Cerebellar hemangioblastoma is a highly vascular benign tumor and the growth rate of hemangioblastomas is believed to often accelerate during pregnancy; however, the reason for this rapid increase in size remains poorly understood. There are several case reports of symptomatic hemangioblastoma during pregnancy; however, the favorable management strategy has not been well established.

Case Description: A 35-year-old woman, gravida 2 para 1, with no significant medical history presented with vertigo and difficulty walking at around 11 weeks of pregnancy and was referred to our institute at 30 weeks of gestation because of worsening symptoms. Read More

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Intramedullary Spinal Cord Lesions: A Single-Center Experience.

Neurospine 2022 Mar 31;19(1):108-117. Epub 2022 Mar 31.

Department of Neurosurgery, University Hospital of Bordeaux, Bordeaux, France.

Objective: Spinal cord tumors constitute a small part of spinal surgery owing to their rarity. This retrospective study describes their current management.

Methods: Forty-eight patients were treated for an intramedullary tumor between 2014 and 2020 at a single institution. Read More

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Suprasellar paraganglioma in a clinical setting of von Hippel-Lindau syndrome.

BMJ Case Rep 2022 Mar 23;15(3). Epub 2022 Mar 23.

Smt Kanuri Santhamma Centre for Vitreo-Retinal Diseases, LV Prasad Eye Institute, Hyderabad, Telangana, India

A man in his 20s presented to the neurosurgery department 2 years ago with headache and blurred vision. He was diagnosed to have a suprasellar mass on neuroimaging. Best-corrected visual acuity in the right eye was 6/36 and that in the left eye was 6/60. Read More

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Branch-like enhancement on contrast enhanced MRI is a specific finding of cerebellar lymphoma compared with other pathologies.

Sci Rep 2022 03 4;12(1):3591. Epub 2022 Mar 4.

Department of Diagnostic Radiology, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Branch-like enhancement (BLE) on contrast-enhanced (CE) magnetic resonance imaging (MRI) was found to be effective in differentiating primary central nervous system lymphoma (PCNSL) from high-grade glioma (HGG) in the cerebellum. However, whether it can be applied to assessments of secondary central nervous system lymphoma (SCNSL), or other cerebellar lesions is unknown. Hence, we retrospectively reviewed cerebellar masses to investigate the use of BLE in differentiating cerebellar lymphoma (CL), both primary and secondary, from other lesions. Read More

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A Challenge in Diagnosis of Cerebellar Hemangioblastoma.

Cureus 2022 Jan 29;14(1):e21713. Epub 2022 Jan 29.

Neurology Department, Hospital Pêro da Covilhã, Covilhã, PRT.

Hemangioblastomas are benign neoplasms, which are highly vascularized and have a slow-growing rate that typically affect the central nervous system; they account for about 1-2.5% of all intracranial tumors and for approximately 2-3% of all intramedullary neoplasms. We present a clinical case of cerebellar hemangioblastoma with six years of evolution, which illustrates the diagnostic difficulties that often arise, especially when the clinical and imaging characteristics escape those usually described and when other clinical findings appear as confounding factors. Read More

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January 2022

Metastasis of Renal Cell Carcinoma to Spinal Hemangioblastoma in a Patient with von Hippel-Lindau Disease: A Case Report.

NMC Case Rep J 2021 5;8(1):129-135. Epub 2021 Jun 5.

Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Chiba, Japan.

von Hippel-Lindau (VHL) disease is characterized by neoplastic and cystic lesions, such as central nervous system (CNS) hemangioblastoma and clear cell renal cell carcinoma (RCC), arising in multiple organs. Here, we report a case of an RCC that metastasized to a spinal hemangioblastoma in a patient diagnosed with VHL disease. This is a unique case study because visceral neoplasms rarely metastasize to the CNS. Read More

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Neuroimaging Features of Optic Nerve Hemangioblastoma Identified by Conventional and Advanced Magnetic Resonance Techniques: A Case Report and Literature Review.

Front Oncol 2021 12;11:763696. Epub 2021 Nov 12.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Optic nerve hemangioblastoma is a very rare benign tumor with only 39 reported cases by now. It appears to be hyperintense on T2-weighted images with a significant enhancement on contrast scans, which are similar to glioma and meningioma. Due to the lack of specificity in MRI manifestations, optic nerve hemangioblastoma is often misdiagnosed. Read More

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November 2021

En-bloc Resection of A Giant Solid Hemangioblastoma of The Vermis.

Neurol India 2021 Sep-Oct;69(5):1200-1203

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Hemangioblastomas (HMB) are extensively vascularized and benign neoplasms that are diagnosed predominantly in adults. The solid type of HMB is technically challenging to operate. The piecemeal resection of the tumor has been shown to have devastating intraoperative complications. Read More

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November 2021

Treatment Strategy for Giant Solid Hemangioblastomas in the Posterior Fossa: A Retrospective Review of 13 Consecutive Cases.

World Neurosurg 2021 Oct 30. Epub 2021 Oct 30.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Objective: To analyze radiologic characteristics, treatment strategy, and treatment outcomes of posterior fossa giant solid hemangioblastomas (GSHBs; ≥4 cm in maximum diameter).

Methods: We performed a retrospective study of 13 consecutive patients (9 male and 4 female patients; mean age, 57.5 ± 13. Read More

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October 2021

Hemangioblastoma diagnosis and surveillance in von Hippel-Lindau disease: a consensus statement.

J Neurosurg 2021 Oct 1:1-6. Epub 2021 Oct 1.

2Department of Neurological Surgery, University of Virginia Health System, Charlottesville, Virginia.

Objective: Hemangioblastomas are a frequent underlying cause of neurological morbidity and death in patients with von Hippel-Lindau disease (VHL). Although these benign tumors can cause significant neurological debility when undetected and untreated, unified evidence-based surveillance recommendations for VHL patients have not been established. To develop consensus recommendations, the VHL Alliance established an expert committee, named the International VHL Surveillance Guidelines Consortium, to define surveillance recommendations. Read More

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October 2021

Investigation and Management of Apparently Sporadic Central Nervous System Haemangioblastoma for Evidence of Von Hippel-Lindau Disease.

Genes (Basel) 2021 09 15;12(9). Epub 2021 Sep 15.

Department of Medical Genetics, University of Cambridge, Cambridge CB2 0QQ, UK.

Haemangioblastomas are rare, highly vascularised tumours that typically occur in the cerebellum, brain stem and spinal cord. Up to a third of individuals with a haemangioblastoma will have von Hippel-Lindau (VHL) disease. Individuals with haemangioblastoma and underlying VHL disease present, on average, at a younger age and frequently have a personal or family history of VHL disease-related tumours (e. Read More

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September 2021

[Consistency analysis between 3D arterial spin labeling and dynamic susceptibility contrast perfusion magnetic resonance imaging in perfusion imaging of brain tumor].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Aug;41(8):1283-1286

Department of Radiology, Hainan Cancer Hospital, Haikou 570300, China.

Objective: To analyze the consistency between cerebral blood flow (CBF) of 3D arterial spin labeling (3D ASL) and dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-PWI) in the measurement of brain tumors.

Methods: Nineteen patients with pathologically confirmed brain tumors were enrolled in this study.The brain tumors included glioma (=9), meningioma (=5), hemangioblastoma (=2), cerebral metastasis (=2) and cavernous hemangioma (=1). Read More

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Commentary: Resection of a Medulla Oblongata Hemangioblastoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 10;21(5):E436-E437

Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA.

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October 2021

Role of MRI in Differentiating Various Posterior Cranial Fossa Space-Occupying Lesions Using Sensitivity and Specificity: A Prospective Study.

Cureus 2021 Jul 12;13(7):e16336. Epub 2021 Jul 12.

Radiodiagnosis, Assam Medical College and Hospital, Dibrugarh, IND.

Background: Any abnormal space-occupying posterior fossa lesion may directly involve the vital structures like the brain stem, cranial nerves, cerebellum, vertebrobasilar artery, and venous sinuses, which makes the surgical approach and total excision very difficult. Hence for these reasons, precise evaluation of posterior fossa lesion with MRI is a must to visualize the vital structures, which helps in planning and safe surgery.  Objective: This study aimed to evaluate the added value of diffusion-weighted imaging and magnetic resonance spectroscopy in the localization, extension, characterization, differentiation of various posterior fossa space-occupying lesions, and correlating with the histopathological result. Read More

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Resection of a Medulla Oblongata Hemangioblastoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 10;21(5):E435

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Hemangioblastomas are benign vascular tumors that can be sporadic or multiple, as part of Von Hippel-Lindau disease. They develop at any level of the central nervous system, with a predilection for the dorsal medulla among brainstem locations. Radical resection of the solid portion of the tumor is the best treatment option. Read More

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October 2021

Surgical management of sporadic hemangioblastomas located in the posterior fossa of brain.

Arch Ital Biol 2021 Jun;159(2):51-63

Department of Neurosurgery, Faculty of Medicine, University of Dicle, 21280, Diyarbakır, Turkey - Email:

Purpose: Hemangioblastomas (HBs) are highly vascular tumors, constituting 2%-3% of central nervous system (CNS) tumors. Surgery is a treatment option for HBs. The purpose of this study was to evaluate the demographic, clinical, and radiological findings of patients with HBs who were operated on via microsurgical technique at our clinic and to determine the findings specific to HBs and evaluate their pathological findings and confirmation. Read More

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Clinical and Laboratory Characteristics of a Large Iranian Kindred Afflicted with Von Hippel Lindau Disease.

Int J Endocrinol Metab 2021 Apr 16;19(2):e105189. Epub 2021 Mar 16.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Von Hippel Lindau (VHL) disease is a hereditary disorder characterized by the development of benign or malignant tumors in the brain, spinal cord, eyes, adrenal medulla, kidney, pancreas, and many other organs. Advances in molecular diagnosis have led to the identification of the affected members of families at earlier stages. We present the clinical, laboratory, and genetic characteristics of five generations of a large Iranian kindred with VHL. Read More

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Pineal Region Hemangioblastoma Resection Through Paramedian Supracerebellar Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 06;21(1):E34-E35

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Pineal region tumors remain challenging lesions to safely resect because of their central location.1 Patients frequently present with symptoms associated with hydrocephalus and brainstem compression.2 Local anatomy, primarily the tentorium angle and venous anatomy, plays a central role in the selection of the approach. Read More

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Pregnancy Promotes the Recurrence of Cerebellar Hemangioblastoma?

J Craniofac Surg 2021 Nov-Dec 01;32(8):e830-e833

Department of Neurosurgery of Shenzhen People's Hospital, Shenzhen, China.

Abstract: Cerebellar hemangioblastomas with pregnancy is rare, but coexistence of pregnancy and recurrent cerebellar hemangioblastomas is rather rare. And coexistence of other diseases during pregnancy usually leads to misdiagnosis because of pregnancy reaction. A 29-year-old woman, at the 8th week of pregnancy, complained of nausea, vomiting, and episodic posterior occipital pain and was misdiagnosed pregnancy reaction without any special treatment during her several visits to local hospital. Read More

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November 2021

Second-Window Indocyanine Green for Visualization of Hemangioblastoma: A Case Report With Two-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 02;20(3):E229-E233

Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Background And Importance: The proper differentiation of neoplastic tissue from adjacent brain parenchyma can pose a great challenge, especially in eloquent areas of the brain. With the novel technique, "Second-Window Indocyanine Green," injection of a near-infrared fluorophore (ICG) allows for intraoperative visualization of tumors by taking advantage of the compromised vasculature surrounding the tumor. Thus, such a technique may demonstrate utility for hemangioblastomas, which are hypervascular tumors of the central nervous system. Read More

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February 2021

Masked malignant phenotype with a benign appearance: beat-up copy number profile may be the key for hemangioblastoma dissemination.

Brain Tumor Pathol 2021 Jan 18;38(1):71-77. Epub 2020 Oct 18.

Department of Neurosurgery, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.

Dissemination of histologically benign hemangioblastoma is rare; approximately 30 cases have previously been reported, and all cases occurred several months to years after surgical resection. Herein, we report a case of hemangioblastoma in which leptomeningeal dissemination occurred 2 years after hypofractionated radiation therapy (39 Gy/13 fractions). The tumor was treated primarily with radiation without surgical resection. Read More

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January 2021

Sporadic Solid/Cystic Hemangioblastomas in the Cerebellum: Retrospective Study of More Than Ten Years of Experience in a Single Center.

World Neurosurg 2020 12 25;144:e908-e915. Epub 2020 Sep 25.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Solid/cystic hemangioblastomas are rare, and they lack a systematic description. We clarify the epidemiology, clinical features, imaging characteristics, and surgical outcomes of sporadic solid/cystic hemangioblastomas in the cerebellum.

Methods: A total of 75 patients with sporadic hemangioblastomas from 2006 to 2018 were enrolled in this retrospective study and divided into solid (26/75), cystic (40/75), and solid/cystic (9/75) groups according to the imaging findings. Read More

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December 2020

Diffuse Cerebral Vasospasm After Removal of a Posterior Fossa Hemangioblastoma in a 62-Year-Old Woman.

World Neurosurg 2020 11 27;143:97-101. Epub 2020 Jul 27.

Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan.

Background: The development of diffuse cerebral vasospasm after the removal of a brain tumor is extremely rare. We report a case of cerebral vasospasm after the removal of a posterior fossa hemangioblastoma.

Case Description: A 62-year-old woman presented with a 1-month history of vertigo and nausea. Read More

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November 2020

Surgical management and outcome of adult posterior cranial fossa and spinal hemangioblastoma: a 6-case series and literature review.

Neurol Res 2020 Dec 22;42(12):1010-1017. Epub 2020 Jul 22.

Department of Neurosurgery, University of Tennessee Health Science Center , Memphis, TN, USA.

Objective: Hemangioblastomas of the posterior cranial fossa and spinal cord in adults are excessively vascularized, well-differentiated, and scarce tumors with no metastatic potential. This paper discusses its surgical management and outcome, pointing out their morphological, radiological, and histopathological aspects. This report based on a personal series of six patients and on a literature review. Read More

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December 2020

Neurosurgical intraoperative ultrasonography using contrast enhanced superb microvascular imaging -vessel density and appearance time of the contrast agent.

Br J Neurosurg 2020 Jul 10:1-10. Epub 2020 Jul 10.

Department of Orthopedics, Edogawa Hospital, Tokyo, Japan.

Ultrasonography (US) provides real-time information on structures within the skull during neurosurgical operations. Superb microvascular imaging (SMI) is the latest imaging technique for detecting very low-velocity flow with minimal motion artifacts, and we have reported on this technique for intraoperative US monitoring. We combined SMI with administration of contrast agent to obtain detailed information during neurosurgical operations. Read More

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Hemangioblastoma and von Hippel-Lindau disease: genetic background, spectrum of disease, and neurosurgical treatment.

Childs Nerv Syst 2020 10 7;36(10):2537-2552. Epub 2020 Jun 7.

Department of Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.

Introduction: Hemangioblastomas are rare, histologically benign, highly vascularized tumors of the brain, the spinal cord, and the retina, occurring sporadically or associated with the autosomal dominant inherited von Hippel-Lindau (VHL) disease. Children or adults with VHL disease have one of > 300 known germline mutations of the VHL gene located on chromosome 3. They are prone to develop hemangioblastomas, extremely rarely starting at age 6, rarely at age 12-18, and, typically and almost all, as adults. Read More

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October 2020

Cerebellar hemangioblastoma during pregnancy: Management options and review of literature.

Surg Neurol Int 2020 23;11:123. Epub 2020 May 23.

Department of Neurosurgery, All India Institute of Medical Science, Raipur, Chhattisgarh, India.

Background: Symptomatic cerebellar hemangioblastomas are extremely rare in pregnant women and the ideal management is not well established. In the present article, we aimed to report a case of large cerebellar hemangioblastoma complicated by pregnancy and managed successfully by surgical resection. In addition, we also discuss management options and review of the current literature pertaining to this pathology. Read More

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