408 results match your criteria Brain Imaging in Hemangioblastoma


Distal Outflow-related Anterior Inferior Cerebellar Artery Aneurysm in Hemangioblastoma.

World Neurosurg 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University. Electronic address:

Anterior inferior cerebellar artery (AICA) aneurysm is a rare cerebral entity and its presentation in association with a hyper-vascularized tumor is even more exceptional. In this study, we presented a patient with rare coexistent pathologies in combination of a cerebellar hypervascularized tumor with an outflow related AICA aneurysm. A one-stage procedure to remove both lesions was carried out following meticulous discussion with patient. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.023DOI Listing

Metastatic Renal Cell Carcinoma to the Brain: A Contemporary Clinicopathologic Analysis With Comparison of Immunohistochemical Profiles to Selected Primary Brain Tumors With Clear Cell Features.

Appl Immunohistochem Mol Morphol 2019 Mar 13. Epub 2019 Mar 13.

Departments of Pathology.

Brain metastases from renal cell carcinoma (RCC) are associated with significant morbidity and mortality. However, there are only few large series in the pathology literature specifically analyzing the clinicopathologic and immunohistochemical features in comparison with primary brain tumors with clear cell features. We identified 34 cases of metastatic RCC to the brain from the Urologic Pathology and Neuropathology files of 2 institutions between 2000 and 2018. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000759DOI Listing
March 2019
1 Read

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas.

Pol J Radiol 2018 10;83:e197-e203. Epub 2018 May 10.

Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Purpose: Haemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.

Material And Methods: The study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.75870
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http://dx.doi.org/10.5114/pjr.2018.75870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323599PMC
May 2018
7 Reads

A Rare Complication of Endovascular Embolization: Extruded Onyx on Trigeminal Nerve.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S422-S423. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.

 To demonstrate a rare complication of endovascular tumor embolization with onyx.  Operative video.  Department of neurological surgery in a university hospital. Read More

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http://dx.doi.org/10.1055/s-0038-1669972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240439PMC
December 2018
15 Reads

Retromedullary Hemangioblastoma Mimicking a Posterior Inferior Cerebellar Artery Aneurysm: Case Report and Literature Review.

World Neurosurg 2019 Feb 4;122:165-170. Epub 2018 Nov 4.

Texas A&M College of Medicine, Temple, Texas, USA; Department of Neurosurgery, Baylor Scott and White Health, Temple, Texas, USA. Electronic address:

Background: Hemangioblastomas (HBMs) are benign vascular neoplasms that most commonly arise within the cerebellum. Although other vascular lesions should be considered in the differential diagnosis, HBMs rarely resemble aneurysms on neuroimaging and only 1 case of a cerebellar HBM mimicking a posterior fossa aneurysm has been reported. Here we describe a retromedullary HBM that masqueraded as a distal posterior inferior cerebellar artery (PICA) medullary branch aneurysm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183249
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http://dx.doi.org/10.1016/j.wneu.2018.10.188DOI Listing
February 2019
17 Reads

The Application of FLOW 800 ICG Videoangiography Color Maps for Neurovascular Surgery and Intraoperative Decision Making.

World Neurosurg 2019 Feb 5;122:e186-e197. Epub 2018 Oct 5.

Department of Neurological Surgery, Goodman Campbell Brain and Spine and Indiana University, Indianapolis, Indiana, USA. Electronic address:

Background: Indocyanine green (ICG) videoangiography can assess cerebral blood flow, but results are primarily qualitative. FLOW 800 software measures fluorescence dynamics and creates a semiquantitative color delay map for assessment of relative sequence of blood flow within the vasculature.

Methods: We retrospectively reviewed 23 consecutive patients for whom FLOW 800 ICG videoangiography was used. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.195DOI Listing
February 2019
2 Reads

Meningioma mimicking an intraparenchymal cystic tumor.

Nagoya J Med Sci 2018 Aug;80(3):431-434

Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Meningiomas rarely exhibit cystic lesions with mural nodules, and may be misdiagnosed as intraparenchymal cystic tumors. We herein present a 64-year-old woman with a cystic lesion and enhancing mural nodule in the left temporal lobe accompanied by peritumoral brain edema. Differential diagnoses included low-grade gliomas, hemangioblastoma, and cystic meningioma. Read More

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http://dx.doi.org/10.18999/nagjms.80.3.431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125649PMC
August 2018
4 Reads

Differentiation of Cerebellar Hemisphere Tumors: Combining Apparent Diffusion Coefficient Histogram Analysis and Structural MRI Features.

J Neuroimaging 2018 Nov 1;28(6):656-665. Epub 2018 Aug 1.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA.

Background And Purpose: We aimed to develop a diagnostic algorithm for differentiation of cerebellar hemisphere tumors, combining Apparent Diffusion Coefficient (ADC) histogram analysis and structural imaging features.

Methods: Pretreatment MRI of patients with pathologically proven cerebellar hemisphere neoplasms were reviewed. Voxel-wise volumetric ADC histograms of tumor solid components were determined. Read More

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http://dx.doi.org/10.1111/jon.12550DOI Listing
November 2018
5 Reads

Suprasellar Hemangioblastoma with Reversible Edema-Like Change Along the Optic Tract: A Case Report and Literature Review.

World Neurosurg 2018 Jun 23;114:187-193. Epub 2018 Mar 23.

Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan.

Background: Hemangioblastomas usually occur in the cerebellum and are often a component of von Hippel-Lindau disease. Edema-like changes along the optic tract are commonly observed in association with tumors in the sellar and suprasellar regions, such as craniopharyngiomas and pituitary adenomas. Here, we describe a case of sporadic suprasellar hemangioblastoma with edema-like changes along the optic tract that completely resolved after surgery. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.03.114DOI Listing
June 2018
9 Reads

Characteristics of time-activity curves obtained from dynamic C-methionine PET in common primary brain tumors.

J Neurooncol 2018 Jul 21;138(3):649-658. Epub 2018 Mar 21.

Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan.

Purpose: The aim of this study was to assess whether dynamic PET with C-methionine (MET) (MET-PET) is useful in the diagnosis of brain tumors.

Methods: One hundred sixty patients with brain tumors (139 gliomas, 9 meningiomas, 4 hemangioblastomas and 8 primary central nervous system lymphomas [PCNSL]) underwent dynamic MET-PET with a 3-dimensional acquisition mode, and the maximum tumor MET-standardized uptake value (MET-SUV) was measured consecutively to construct a time-activity curve (TAC). Furthermore, receiver operating characteristic (ROC) curves were generated from the time-to-peak (TTP) and the slope of the curve in the late phase (SLOPE). Read More

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http://dx.doi.org/10.1007/s11060-018-2834-4DOI Listing
July 2018
7 Reads

Automatic intraoperative estimation of blood flow direction during neurosurgical interventions.

Int J Comput Assist Radiol Surg 2018 May 13;13(5):693-701. Epub 2018 Mar 13.

Department of Medical Technology, SINTEF Health, Trondheim, Norway.

Purpose: In neurosurgery, reliable information about blood vessel anatomy and flow direction is important to identify, characterize, and avoid damage to the vasculature. Due to ultrasound Doppler angle dependencies and the complexity of the vascular architecture, clinically valuable 3-D flow direction information is currently not available. In this paper, we aim to clinically validate and demonstrate the intraoperative use of a fully automatic method for estimation of 3-D blood flow direction from freehand 2-D Doppler ultrasound. Read More

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http://dx.doi.org/10.1007/s11548-018-1711-0DOI Listing
May 2018
3 Reads

Presentation of a Hemangioblastoma in cavernous sinus: An extremely rare case report.

Int J Surg Case Rep 2018 17;44:54-56. Epub 2018 Feb 17.

Neurosurgery, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: Hemangioblastoma (HB) is a benign vascular tumor that accounts for about 2% of intracranial neoplasms. HB of the cavernous sinus (CS) is extremely rare. Only one report was found in the literature. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5927805PMC
February 2018
1 Read

Usefulness of 18F-fluorodeoxyglucose-Positron Emission Tomography in Comparison with Methionine-Positron Emission Tomography in Differentiating Solid Hemangioblastoma from Adult Cerebellar Tumors.

World Neurosurg 2018 Feb 21;110:e648-e652. Epub 2017 Nov 21.

Department of Neurosurgery, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Background And Purpose: Among adults with posterior fossa tumors, an intraaxial location of the tumor is less common than an extraaxial location. Moreover, the differential diagnosis of a single cerebellar tumor in adults is sometimes difficult by conventional magnetic resonance imaging. We aimed to report the findings of positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) and methionine in adult patients with intraaxial and solitary metastatic brain tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.11.054DOI Listing
February 2018
7 Reads

Von Hippel-Lindau Disease With Multi-Organ Involvement: A Case Report and 8-Year Clinical Course With Follow-Up.

Am J Case Rep 2017 Nov 17;18:1220-1224. Epub 2017 Nov 17.

Department of Radiation Oncology, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

BACKGROUND Von Hippel-Lindau (VHL) disease is a rare autosomal dominant syndrome manifested by a spectrum of benign and malignant tumors.  CASE REPORT The patient presented here was a 31-year-old female with unremarkable family history who presented initially complaining of intermittent abdominal pain. Abdominal CT scan revealed an inhomogeneous solid mass (13×9×7 cm) originating from the tail of the pancreas with splenic and gastric invasion as well as several pancreatic cysts. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701459PMC
November 2017
9 Reads

Microsphere Embolization of Hypervascular Posterior Fossa Tumors.

World Neurosurg 2018 Jan 3;109:182-187. Epub 2017 Oct 3.

Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Background: Preoperative embolization of highly vascular tumors of the posterior fossa can decrease morbidity and operative blood loss. No clear consensus exists for the embolization agent of choice for optimal devascularization of these tumors. The purpose of this study was to assess effectiveness of microsphere embolization in reducing tumor hypervascularity before surgical resection. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.09.147DOI Listing
January 2018
11 Reads

Cystic supratentorial mass in a middle-aged patient: MR imaging findings with histopathologic correlation.

Acta Neurol Belg 2017 12 25;117(4):909-913. Epub 2017 Sep 25.

Department of Medical Imaging, University Hospital (UZ) Gent, Gent, Belgium.

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http://link.springer.com/10.1007/s13760-017-0841-4
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http://dx.doi.org/10.1007/s13760-017-0841-4DOI Listing
December 2017
7 Reads

Radiologic Features and Surgical Strategy of Hemangioblastomas with Enhanced Cyst Wall.

World Neurosurg 2017 Dec 1;108:143-150. Epub 2017 Sep 1.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objective: Hemangioblastomas with enhanced cyst walls represent a rare radiologic presentation of hemangioblastomas with poor understandings. We aimed to summarize the clinical and radiologic features, important differential diagnosis, surgical strategy, and clinical outcome of this rare entity.

Methods: From June 2008 to March 2017, 12 patients with cystic hemangioblastomas presenting with enhanced wall thickness on MRI were treated in our department. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.08.155DOI Listing
December 2017
2 Reads

Differential diagnosis of posterior fossa brain tumors: Multiple discriminant analysis of Tl-SPECT and FDG-PET.

Medicine (Baltimore) 2017 Aug;96(33):e7767

aDepartment of Diagnostic Imaging and Nuclear Medicine bDepartment of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

This study investigated the combined capability of thallium-201 (Tl)-SPECT and fluorine-18-fluoro-deoxy-glucose (FDG)-PET for differential diagnosis of posterior fossa brain tumors using multiple discriminant analysis.This retrospective study was conducted under approval of the institutional review board. In the hospital information system, 27 patients with posterior fossa intra-axial tumor between January 2009 and June 2015 were enrolled and grouped as the following 7 entities: low grade glioma (LGG) 6, anaplastic astrocytoma (AA) 2, glioblastoma (GBM) 3, medulloblastoma (MB) 3, hemangioblastoma (HB) 6, metastatic tumor (Mets) 3, and malignant lymphoma (ML) 4. Read More

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http://dx.doi.org/10.1097/MD.0000000000007767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5571693PMC
August 2017
13 Reads

Pediatric central nervous system hemangioblastomas: different from adult forms? A retrospective series of 25 cases.

Acta Neurochir (Wien) 2017 09 27;159(9):1603-1611. Epub 2017 Jul 27.

Department of Neurosurgery West China Hospital, Sichuan University, 37 Guo Xue Xiang, Wu Hou District, Chengdu, 610041, Sichuan, People's Republic of China.

Background: Pediatric hemangioblastomas are rare, and the clinical features, timing of surgical intervention, optimal treatment, and clinical outcomes are still unclear.

Methods: We performed a retrospective study of all patients with CNS hemangioblastomas who were treated at West China Hospital from January 2003 to March 2015. Patients under the age of 16 years were included in the study. Read More

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http://dx.doi.org/10.1007/s00701-017-3275-0DOI Listing
September 2017
5 Reads

[Preoperative Embolization for Solid Cerebellar Hemangioblastoma on the Day of Surgery:Two Case Reports].

No Shinkei Geka 2017 Jul;45(7):615-622

Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.

Surgical resection of solid cerebellar hemangioblastomas can be challenging because of the profuse blood supply and tight space. We report two cases of solid cerebellar hemangioblastomas treated via surgical resection with the aid of preoperative endovascular embolization on the day of surgery. Case 1: A 36-year-old woman presented with a two-month history of headache and vomiting. Read More

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http://dx.doi.org/10.11477/mf.1436203560DOI Listing
July 2017
2 Reads

Recurrent or symptomatic residual posterior fossa hemangioblastomas: how are they different from their primary counterparts?

Acta Neurochir (Wien) 2017 08 11;159(8):1497-1510. Epub 2017 Jun 11.

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, India.

Background: Posterior fossa hemangioblastomas are WHO grade I benign lesions with a surprisingly high recurrence rate. This study determines the factors responsible for recurrence and the clinico-radiological and histopathological differences between primary (group A; n = 60) and recurrent/symptomatic residual (group B; n = 24) tumors.

Methods: Radiologically, tumors were differentiated into cystic, cystic with a mural nodule, solid-cystic/microcystic and solid. Read More

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http://dx.doi.org/10.1007/s00701-017-3225-xDOI Listing
August 2017
20 Reads

Status Epilepticus Secondary to Pseudonodular Hemorragic Occipital Lesion with Edema: "Non Semper Ea Sunt, Quae Videntur, Decipit Frons Prima Multos" (Things Are Not Always What They Seem; The First Appearance Deceives Many).

World Neurosurg 2017 Aug 27;104:1044.e1-1044.e3. Epub 2017 May 27.

Department of Neurosurgery, Institute for Scientific and Care Research, Main Hospital of Santa Maria Nuova, Reggio Emilia, Italy; Neurosurgery-Neurotraumatology Unit, University Hospital of Parma, Parma, Italy.

We report a case in which common radiologic images masked a rare case of supratentorial hemangioblastoma (HBL). Other peculiarities of this case are the clinical presentation with status epilepticus and the occurrence of a supratentorial HBL unrelated to von Hippel-Lindau syndrome. Based on clinical and radiologic findings, including massive cerebral edema and hemorrhagic presentation, our preoperative diagnosis was a cerebral metastasis. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.05.114DOI Listing
August 2017
13 Reads

Operative simulation of anterior clinoidectomy using a rapid prototyping model molded by a three-dimensional printer.

Acta Neurochir (Wien) 2017 Sep 15;159(9):1619-1626. Epub 2017 May 15.

Department of Neurosurgery (Omori), Toho University Graduate School of Medicine, 6-11-1, Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan.

Background: As the anatomical three-dimensional (3D) positional relationship around the anterior clinoid process (ACP) is complex, experience of many surgeries is necessary to understand anterior clinoidectomy (AC). We prepared a 3D synthetic image from computed tomographic angiography (CTA) and magnetic resonance imaging (MRI) data and a rapid prototyping (RP) model from the imaging data using a 3D printer. The objective of this study was to evaluate anatomical reproduction of the 3D synthetic image and intraosseous region after AC in the RP model. Read More

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http://dx.doi.org/10.1007/s00701-017-3202-4DOI Listing
September 2017
5 Reads

Prevalence of Abnormal Magnetic Resonance Imaging Findings in Children with Persistent Symptoms after Pediatric Sports-Related Concussion.

J Neurotrauma 2017 10 19;34(19):2706-2712. Epub 2017 Jul 19.

1 Harborview Injury Prevention Research Center, Harborview Medical Center, University of Washington , Seattle, Washington.

A subset of patients experience persistent symptoms after pediatric concussion, and magnetic resonance imaging (MRI) is commonly used to evaluate for pathology. The utility of this practice is unclear. We conducted a retrospective cohort study to describe the MRI findings in children with concussion. Read More

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http://dx.doi.org/10.1089/neu.2017.4970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824661PMC
October 2017
15 Reads

Rapid, label-free identification of cerebellar structures using multiphoton microscopy.

J Biophotonics 2017 Dec 2;10(12):1617-1626. Epub 2017 May 2.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory of Photonics Technology, Fujian Normal University, Fuzhou, 350007, P. R. China.

The cerebellum is the prominent laminar structure of the mammalian brain that has been implicated in various psychiatric and neurological diseases. Although clinical brain imaging techniques have provided precise anatomic images of cerebellar structures, a definitive diagnosis still requires adequate resolution to identify individual layers in cerebellar cortex, the extent of tumor, even requires the histological tissue examination during surgical procedures. In this study, multiphoton microscopy (MPM), based on second harmonic generation (SHG) and two-photon excited fluorescence (TPEF), was perform on the rat cerebellar structures and pathology with the combination of image analysis methods. Read More

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http://dx.doi.org/10.1002/jbio.201600297DOI Listing
December 2017
22 Reads

Cerebellar ependymoma with overlapping features of clear-cell and tanycytic variants mimicking hemangioblastoma: a case report and literature review.

Diagn Pathol 2017 Mar 20;12(1):28. Epub 2017 Mar 20.

Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, 110001, China.

Background: Imaging and histology of clear-cell ependymoma and cerebellum-based hemangioblastoma are similar; distinguishing between them is a diagnostic challenge.

Case Presentation: A 62-year-old Chinese woman presented with an intermittent headache of 8 years' duration. Computed tomography and magnetic resonance imaging revealed a mass in the cerebellum. Read More

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http://dx.doi.org/10.1186/s13000-017-0619-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359883PMC
March 2017
8 Reads

5ALA in pediatric brain tumors is not routinely beneficial.

Childs Nerv Syst 2017 May 14;33(5):787-792. Epub 2017 Mar 14.

Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel Aviv Medical Center, Tel Aviv University, 6 Weizman Street, 64239, Tel Aviv, Israel.

Purpose: Over recent years, 5-aminoluvolinic acid (5ALA) has been increasingly used for resection guidance in adult high-grade gliomas. However, amongst pediatric patients, publication of intraoperative fluorescence has been limited, with inconsistent outcomes. We describe our experience and intraoperative finding amongst children with various brain tumors that were given 5ALA prior to tumor resection. Read More

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http://dx.doi.org/10.1007/s00381-017-3371-8DOI Listing
May 2017
11 Reads

Advantage of High b Value Diffusion-Weighted Imaging for Differentiation of Hemangioblastoma from Brain Metastases in Posterior Fossa.

World Neurosurg 2017 May 4;101:643-650. Epub 2017 Feb 4.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Minami-ku, Hiroshima-city, Hiroshima, Japan. Electronic address:

Objective: It is sometimes difficult to make a differential diagnosis between brain metastases and hemangioblastomas in the posterior fossa. We assessed whether high b value diffusion-weighted image (DWI) at b = 4000 could differentiate these tumors.

Methods: We acquired DWI at 3-T magnetic resonance imaging with b = 1000 and b = 4000 seconds/mm in histologically confirmed 12 patients of hemangioblastoma without von Hippel-Lindau disease and 16 patients with brain metastases originating at the posterior fossa. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.01.100DOI Listing
May 2017
9 Reads
2.420 Impact Factor

Central positional nystagmus associated with cerebellar tumors: Clinical and topographical analysis.

J Neurol Sci 2017 Feb 27;373:147-151. Epub 2016 Dec 27.

Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju, Republic of Korea. Electronic address:

Purpose: Positional nystagmus is usually caused by peripheral vestibular disorder, mostly benign paroxysmal positional vertigo (BPPV). However, positional nystagmus is also encountered in central lesions. We aimed to determine clinical characteristics of the structures responsible for central positional nystagmus (CPN) associated with brain tumors. Read More

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http://dx.doi.org/10.1016/j.jns.2016.12.050DOI Listing
February 2017
28 Reads

Hypervascular Lesions of the Cerebellopontine Angle: The Relevance of Angiography as a Diagnostic and Therapeutic Tool and the Role of Stereotactic Radiosurgery in Management. A Comprehensive Review.

World Neurosurg 2017 Apr 31;100:100-117. Epub 2016 Dec 31.

Division of Neurosurgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: The cerebellopontine angle (CPA) is a narrowed skull base area containing important cranial nerves and vessels and bordering with eloquent areas of the posterior fossa. Tumors of the CPA are a heterogeneous group and can have extradural, intradural/extra-axial, or intra-axial origins. Their vascular supply changes depending on their anatomic origin. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.12.091DOI Listing
April 2017
2 Reads

Ruptured Massa Intermedia Secondary to Hydrocephalus.

World Neurosurg 2017 Jan 4;97:749.e7-749.e10. Epub 2016 Nov 4.

Department of Neurosurgery, University Medicine Greifswald, Greifswald, Germany.

Background: We report a case of ruptured massa intermedia (MI) as a sequela of hydrocephalus.

Case Description: A single case report is presented describing the sequelae of tumor bed hematoma after a posterior fossa hemangioblastoma resection in which the patient bled 3 days after surgery, resulting in secondary hydrocephalus and subsequently dilatation of the third ventricle, which resulted in rupture of the MI. The patient was managed on emergency basis with an external ventricular drain then endoscopically with a third ventriculostomy and clot extraction. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.10.131DOI Listing
January 2017
5 Reads
2.420 Impact Factor

Bulbar dysfunction and aspiration pneumonia due to a brainstem haemangioblastoma: an unusual complication of von Hippel-Lindau disease.

BMJ Case Rep 2016 Oct 13;2016. Epub 2016 Oct 13.

Department of Medical Genetics, University of Cambridge School of Clinical Medicine, Cambridge, UK.

A 44-year-old woman with a history of von Hippel-Lindau (VHL) disease, a rare inherited neoplasia syndrome, presented acutely to hospital with a productive cough, symptoms of respiratory tract infection and odynophagia (painful swallowing). A chest X-ray confirmed right-sided pneumonia. Investigation of the persistent odynophagia using barium swallow revealed aspiration of the contrast into the lungs and suggested a neurological cause for her chest infection. Read More

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http://dx.doi.org/10.1136/bcr-2016-217076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073630PMC
October 2016
6 Reads

Unusual case of recurrent SMART (stroke-like migraine attacks after radiation therapy) syndrome.

Ann Indian Acad Neurol 2016 Jul-Sep;19(3):399-401

Associate Professor of Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, United States.

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare delayed complication of cerebral radiation therapy. A 53-year-old female initially presented with headache, confusion and left homonymous hemianopia. Her medical history was notable for cerebellar hemangioblastoma, which was treated with radiation in 1987. Read More

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http://dx.doi.org/10.4103/0972-2327.168634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980969PMC
August 2016
38 Reads
3 Citations
0.514 Impact Factor

Intraoperative fluorescein staining for benign brain tumors.

Clin Neurol Neurosurg 2016 Oct 11;149:22-6. Epub 2016 Jul 11.

Department of Neurosurgery, University Hospital "Saint Ivan Rilski", Sofia, Bulgaria.

Objective: Successful use of high-dose fluorescein-sodium (20mg/kg) with a standard light microscope for resection of high-grade gliomas, meningiomas, hemangioblastoma and metastases was reported. The principle of brain tumor staining by fluorescein-sodium (Fl-Na) consists in the accumulation of fluorescein in brain tumors with impaired blood-brain barrier. The aim of our study was to investigate for the first time the usefulness of high-dose fluorescein in patients operated on for benign neuroepithelial brain tumors (grade I WHO tumors) with contrast enhancement on magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.clineuro.2016.07.016DOI Listing
October 2016
9 Reads

Genotype-phenotype analysis of von Hippel-Lindau syndrome in Korean families: HIF-α binding site missense mutations elevate age-specific risk for CNS hemangioblastoma.

BMC Med Genet 2016 07 20;17(1):48. Epub 2016 Jul 20.

Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

Background: von Hippel-Lindau (VHL) disease is a rare hereditary tumor syndrome caused by VHL gene mutations that is characterized by heterogeneous phenotypes such as benign/malignant tumors of the central nervous system, retina, kidney, adrenal gland, and pancreas. The genotype-phenotype correlation has not been well characterized in the Korean population so far. Therefore, this study aimed to evaluate the VHL mutation spectrum and genotype-phenotype correlations in Korean VHL patients. Read More

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http://dx.doi.org/10.1186/s12881-016-0306-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955248PMC
July 2016
39 Reads

Neuroimaging of spine tumors.

Handb Clin Neurol 2016 ;136:689-706

Dent Neurologic Institute, Amherst, NY, USA. Electronic address:

Intramedullary, intradural/extramedullary, and extradural spine tumors comprise a wide range of neoplasms with an even wider range of clinical symptoms and prognostic features. Magnetic resonance imaging (MRI), commonly used to evaluate the spine in patients presenting with pain, can further characterize lesions that may be encountered on other imaging studies, such as bone scintigraphy or computed tomography (CT). The advantage of the MRI is its multiplane capabilities, superior contrast agent resolution, and flexible protocols that play an important role in assessing tumor location, extent in directing biopsy, in planning proper therapy, and in evaluating therapeutic results. Read More

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http://dx.doi.org/10.1016/B978-0-444-53486-6.00033-8DOI Listing
February 2017
10 Reads

The significance of incidental brain uptake on 68Ga-DOTATATE PET-CT in neuroendocrine tumour patients.

Nucl Med Commun 2016 Nov;37(11):1197-205

Departments of aNuclear Medicine bRadiology, Royal Free London NHS Foundation Trust, London, UK cMelbourne Brain Centre Imaging Unit, Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Australia.

Objective: Radiolabelled somatostatin analogues detect neuroendocrine tumours (NETs), but may reveal other tumour types. We examined the prevalence of possible meningioma in patients with known or suspected NETs imaged with Ga-DOTATATE PET-computed tomography (CT) on the basis of central nervous system uptake and compared with findings on magnetic resonance and contrast-enhanced CT imaging.

Methods: Retrospective imaging reports from 313 patients who had undergone Ga-DOTATATE PET imaging for primary or repeat NET staging were searched to identify suspected meningiomas on PET. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000571DOI Listing
November 2016
10 Reads

Metastatic cerebellar tumor of papillary thyroid carcinoma mimicking cerebellar hemangioblastoma.

Springerplus 2016 29;5(1):916. Epub 2016 Jun 29.

Department of Pathology, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Introduction: Well-differentiated papillary thyroid carcinoma generally (PTC) have a favorable prognosis. This metastasis is rare in the central nervous system. Brain metastasis has a relatively poor prognosis. Read More

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http://dx.doi.org/10.1186/s40064-016-2551-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927557PMC
July 2016
2 Reads

Hemangioblastoma located in the posterior incisural space mimicking a tentorial meningioma: a case report.

J Med Case Rep 2016 Jun 23;10(1):183. Epub 2016 Jun 23.

Institute of Medical Research A Lanari, University of Buenos Aires, Combatiente de Malvinas 3150. 1427, Buenos Aires, Argentina.

Background: The most common type of vascularized tumor located in the posterior incisural space in older patients is the falcotentorial meningioma. Solid hemangioblastomas are rarely found in this particular area of the brain. To the best of our knowledge, the case of only one patient harboring a hemangioblastoma not associated with Von Hippel-Lindau disease has been previously reported in the literature in this anatomic region. Read More

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http://dx.doi.org/10.1186/s13256-016-0962-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918118PMC
June 2016
20 Reads

Differentiating Hemangioblastomas from Brain Metastases Using Diffusion-Weighted Imaging and Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted MR Imaging.

AJNR Am J Neuroradiol 2016 Oct 12;37(10):1844-1850. Epub 2016 May 12.

From the Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.

Background And Purpose: On DWI and DSC-PWI, hemangioblastomas and brain metastases may exhibit different signal intensities depending on their cellularity and angiogenesis. The purpose of this study was to evaluate whether a hemangioblastoma can be differentiated from a single brain metastasis with DWI and DSC-PWI.

Materials And Methods: We retrospectively reviewed DWI, DSC-PWI, and conventional MR imaging of 21 patients with hemangioblastomas and 30 patients with a single brain metastasis. Read More

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http://dx.doi.org/10.3174/ajnr.A4809DOI Listing
October 2016
5 Reads

Suprasellar Hemangioblastoma Unrelated to von Hippel-Lindau Disease Successfully Treated through Extended Transsphenoidal Approach: Diagnostic Value of Von Hippel-Lindau Disease Gene-Derived Protein.

J Neurol Surg A Cent Eur Neurosurg 2017 May 28;78(3):296-301. Epub 2016 Apr 28.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Hemangioblastoma tends to occur in the infratentorial regions and rarely in the supratentorial regions. This tumor is strongly associated with von Hippel-Lindau disease (VHLD), especially in the supratentorial regions, with only 12 cases of suprasellar hemangioblastoma unrelated to VHLD. However, all these cases were diagnosed based on clinical screening and confirmation of family history. Read More

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http://dx.doi.org/10.1055/s-0036-1582016DOI Listing
May 2017
22 Reads

Differentiation of Hemangioblastoma from Metastatic Brain Tumor using Dynamic Contrast-enhanced MR Imaging.

Clin Neuroradiol 2017 Sep 7;27(3):329-334. Epub 2016 Mar 7.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, 135-710, Seoul, Republic of Korea.

Purpose: The aim of this study was to differentiate hemangioblastomas from metastatic brain tumors using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and compare the diagnostic performances with diffusion-weighted imaging (DWI) and dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI).

Methods: We retrospectively reviewed 7 patients with hemangioblastoma and 15 patients with metastatic adenocarcinoma with magnetic resonance imaging (MRI) including DWI, DSC-MRI, and DCE-MRI. Apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), and DCE-MRI parameters (K , k , v , and v ) were compared between the two groups. Read More

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http://dx.doi.org/10.1007/s00062-016-0508-1DOI Listing
September 2017
1 Read

The Trans-Visible Navigator: A See-Through Neuronavigation System Using Augmented Reality.

World Neurosurg 2016 Mar 28;87:399-405. Epub 2015 Dec 28.

Department of Neurosurgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.

Introduction: The neuronavigator has become indispensable for brain surgery and works in the manner of point-to-point navigation. Because the positional information is indicated on a personal computer (PC) monitor, surgeons are required to rotate the dimension of the magnetic resonance imaging/computed tomography scans to match the surgical field. In addition, they must frequently alternate their gaze between the surgical field and the PC monitor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750150170
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http://dx.doi.org/10.1016/j.wneu.2015.11.084DOI Listing
March 2016
4 Reads

Infundibular Hemangioblastoma in a Patient with Neurofibromatosis Type 1: Case Report and Review of the Literature.

World Neurosurg 2016 Apr 25;88:693.e7-12. Epub 2015 Dec 25.

Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; University of Cincinnati Neuroscience Institute, Cincinnati, Ohio, USA; Mayfield Clinic, Cincinnati, Ohio, USA. Electronic address:

Background: Supratentorial hemangioblastomas are rare tumors, most commonly occurring in the sellar/suprasellar region, cerebrum, and ventricle. They are generally found in patients with von Hippel Lindau disease but have infrequently been reported in patients without this syndrome.

Case Description: A 35-year-old woman with a history of neurofibromatosis type 1 presented to our care with visual loss and headaches. Read More

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http://dx.doi.org/10.1016/j.wneu.2015.12.030DOI Listing
April 2016
5 Reads

Neuro-Ophthalmic and Clinical Characteristics of Brain Tumours in a Tertiary Hospital in Ghana.

Ghana Med J 2015 Sep;49(3):181-6

University of Ghana Dental School, College of Health Sciences, Korle-Bu Teaching Hospital, Accra, Ghana.

Background: Anecdotally, increasing number of patients are seen at Korle Bu Teaching Hospital (KBTH) with brain tumour. Neuro-ophthalmic symptoms and signs may help in timely diagnosis and intervention.

Objective: To evaluate the neuro-ophthalmic and clinical characteristics of brain tumour in patients presenting at a tertiary hospital in Ghana. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676598PMC
September 2015
5 Reads

Tuberculous meningitis with dementia as the presenting symptom after intramedullary spinal cord tumor resection.

Nagoya J Med Sci 2015 Nov;77(4):653-7

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Early-stage TB meningitis has no specific symptoms in patients, potentially leading to delayed diagnosis and consequently worsening prognosis. The authors present the fatal case with a delayed diagnosis of tuberculous (TB) meningitis with dementia as the presenting symptom after intramedullary spinal cord tumor resection. The medical records, operative reports, and radiographical imaging studies of a single patient were retrospectively reviewed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664597PMC
November 2015
24 Reads

Biological and clinical impact of hemangioblastoma-associated peritumoral cysts in von Hippel-Lindau disease.

J Neurosurg 2016 Apr 30;124(4):971-6. Epub 2015 Oct 30.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio;

Objective: Peritumoral cysts are frequently associated with CNS hemangioblastomas and often underlie neurological morbidity and mortality. To determine their natural history and clinical impact, the authors prospectively analyzed hemangioblastoma-associated peritumoral cysts in patients with von Hippel-Lindau (VHL) disease.

Methods: Patients with VHL disease who had 2 or more years of follow-up and who were enrolled in a prospective study at the National Institutes of Health were included. Read More

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http://dx.doi.org/10.3171/2015.4.JNS1533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818154PMC
April 2016
12 Reads

Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review.

CNS Oncol 2015 26;4(6):387-92. Epub 2015 Oct 26.

Centre of Oncology, University Hospital of Geneva, Geneva, Switzerland.

Hemangioblastoma is a rare benign neoplasm, accounting for less than 2% of all primitive brain tumors. It may arise sporadically in a solitary form, or associated with Von Hippel-Lindau (VHL) disease with multiple tumors. Surgery is the mainstay treatment, but management is challenging in case of recurrent and/or multiple tumors. Read More

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http://dx.doi.org/10.2217/cns.15.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083944PMC
August 2016
27 Reads
1 Citation

A case of 3p deletion syndrome associated with cerebellar hemangioblastoma.

Brain Dev 2016 Feb 11;38(2):257-60. Epub 2015 Sep 11.

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.

We described clinical course of a 24-year-old woman with 3p deletion syndrome associated with cerebellar hemangioblastoma at the age of 16 years old. She presented dysmorphic facial features, growth retardation and severe psychomotor retardation associated with 3p deletion syndrome. We identified de novo 3p deletion encompassing p25 by using array-based comparative genomic hybridization, where causative gene of von Hippel-Lindau (VHL) disease located. Read More

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http://dx.doi.org/10.1016/j.braindev.2015.07.005DOI Listing
February 2016
18 Reads

Clinical presentation and mutation analysis of VHL disease in a large Chinese family.

J Neurooncol 2015 Nov 4;125(2):369-75. Epub 2015 Sep 4.

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited neoplastic disorder characterized by marked phenotypic variability and age-dependent penetrance. This disease is caused by germline mutations in the VHL tumor suppressor gene. Systematic physical examinations, imaging assessments and molecular genetic tests for the VHL gene were performed in a large Chinese VHL family. Read More

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http://link.springer.com/content/pdf/10.1007/s11060-015-1924
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http://link.springer.com/10.1007/s11060-015-1924-9
Publisher Site
http://dx.doi.org/10.1007/s11060-015-1924-9DOI Listing
November 2015
13 Reads