437 results match your criteria Brain Imaging in Hemangioblastoma


Pregnancy Promotes the Recurrence of Cerebellar Hemangioblastoma?

J Craniofac Surg 2021 Apr 15. Epub 2021 Apr 15.

Department of Neurosurgery of Wuhan Third Hospital Department of Surgery and Anesthesia, Taikang Tongji (Wuhan) Hospital, Wuhan Department of Neurosurgery of Shenzhen People's Hospital, Shenzhen, China.

Abstract: Cerebellar hemangioblastomas with pregnancy is rare, but coexistence of pregnancy and recurrent cerebellar hemangioblastomas is rather rare. And coexistence of other diseases during pregnancy usually leads to misdiagnosis because of pregnancy reaction. A 29-year-old woman, at the 8th week of pregnancy, complained of nausea, vomiting, and episodic posterior occipital pain and was misdiagnosed pregnancy reaction without any special treatment during her several visits to local hospital. Read More

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Second-Window Indocyanine Green for Visualization of Hemangioblastoma: A Case Report With Two-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Feb;20(3):E229-E233

Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

Background And Importance: The proper differentiation of neoplastic tissue from adjacent brain parenchyma can pose a great challenge, especially in eloquent areas of the brain. With the novel technique, "Second-Window Indocyanine Green," injection of a near-infrared fluorophore (ICG) allows for intraoperative visualization of tumors by taking advantage of the compromised vasculature surrounding the tumor. Thus, such a technique may demonstrate utility for hemangioblastomas, which are hypervascular tumors of the central nervous system. Read More

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February 2021

Sporadic Solid/Cystic Hemangioblastomas in the Cerebellum: Retrospective Study of More Than Ten Years of Experience in a Single Center.

World Neurosurg 2020 12 25;144:e908-e915. Epub 2020 Sep 25.

Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Solid/cystic hemangioblastomas are rare, and they lack a systematic description. We clarify the epidemiology, clinical features, imaging characteristics, and surgical outcomes of sporadic solid/cystic hemangioblastomas in the cerebellum.

Methods: A total of 75 patients with sporadic hemangioblastomas from 2006 to 2018 were enrolled in this retrospective study and divided into solid (26/75), cystic (40/75), and solid/cystic (9/75) groups according to the imaging findings. Read More

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December 2020

Diffuse Cerebral Vasospasm After Removal of a Posterior Fossa Hemangioblastoma in a 62-Year-Old Woman.

World Neurosurg 2020 11 27;143:97-101. Epub 2020 Jul 27.

Department of Neurosurgery, Nakamura Memorial Hospital, Sapporo, Japan.

Background: The development of diffuse cerebral vasospasm after the removal of a brain tumor is extremely rare. We report a case of cerebral vasospasm after the removal of a posterior fossa hemangioblastoma.

Case Description: A 62-year-old woman presented with a 1-month history of vertigo and nausea. Read More

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November 2020

Neurosurgical intraoperative ultrasonography using contrast enhanced superb microvascular imaging -vessel density and appearance time of the contrast agent.

Br J Neurosurg 2020 Jul 10:1-10. Epub 2020 Jul 10.

Department of Orthopedics, Edogawa Hospital, Tokyo, Japan.

Ultrasonography (US) provides real-time information on structures within the skull during neurosurgical operations. Superb microvascular imaging (SMI) is the latest imaging technique for detecting very low-velocity flow with minimal motion artifacts, and we have reported on this technique for intraoperative US monitoring. We combined SMI with administration of contrast agent to obtain detailed information during neurosurgical operations. Read More

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Cerebellar hemangioblastoma during pregnancy: Management options and review of literature.

Surg Neurol Int 2020 23;11:123. Epub 2020 May 23.

Department of Neurosurgery, All India Institute of Medical Science, Raipur, Chhattisgarh, India.

Background: Symptomatic cerebellar hemangioblastomas are extremely rare in pregnant women and the ideal management is not well established. In the present article, we aimed to report a case of large cerebellar hemangioblastoma complicated by pregnancy and managed successfully by surgical resection. In addition, we also discuss management options and review of the current literature pertaining to this pathology. Read More

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Pearls and Pitfalls in Interpretation of 68Ga-DOTATOC PET Imaging.

Clin Nucl Med 2020 Jun;45(6):e279-e280

From the Departments of Clinical Physiology, Nuclear Medicine, and PET.

DOTA-D-Phe-Tyr-octreotide labeled with Ga (Ga-DOTATOC) is the commonly used PET tracer for imaging meningioma because of its high affinity to somatostatin receptor subtype 2 (SSTR2) and an established imaging modality for planning radiation and radionuclide therapy. However, SSTR2 is not an exclusive marker for meningioma, and not all meningiomas express high levels of SSTR2. The SSTR2 expression has been reported in other intracranial tumors, for example, glioma, pituitary adenoma, medullablastoma, primitive neuroectodermal tumors, and hemangioblastoma leading to a significant risk of misinterpretation of PET/CT findings. Read More

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Diagnostic challenges of posterior fossa hemangioblastomas: Refining current radiological classification scheme.

Sci Rep 2020 04 14;10(1):6267. Epub 2020 Apr 14.

Department of Neurosurgery, Brain Tumor Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

Hemangioblastomas (HBMs) are known to exhibit very typical radiological features and thus classified by well-established radiological classification scheme. We reviewed our series of posterior fossa HBMs in order not only to evaluate the relevance of current classification scheme, but also to possibly refine it. Also, we added descriptions on several cases with unusual radiological magnetic resonance imaging (MRI) findings in which differential diagnosis was challenging. Read More

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Machine Learning Decision Tree Models for Differentiation of Posterior Fossa Tumors Using Diffusion Histogram Analysis and Structural MRI Findings.

Front Oncol 2020 7;10:71. Epub 2020 Feb 7.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States.

We applied machine learning algorithms for differentiation of posterior fossa tumors using apparent diffusion coefficient (ADC) histogram analysis and structural MRI findings. A total of 256 patients with intra-axial posterior fossa tumors were identified, of whom 248 were included in machine learning analysis, with at least 6 representative subjects per each tumor pathology. The ADC histograms of solid components of tumors, structural MRI findings, and patients' age were applied to construct decision models using Classification and Regression Tree analysis. Read More

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February 2020

A Large Solitary Hemangioblastoma of the Lateral Ventricles: A Case Report and Literature Review.

Iran J Med Sci 2020 Jan;45(1):67-72

Department of Neurosurgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Hemangioblastoma (HB) in the supratentorial region of the brain is rare and only a few cases are reported on intraventricular HB. HB of the lateral ventricles is even rarer. We present a case of a 30-year-old man with generalized tonic clonic seizures. Read More

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January 2020

A novel neuroimaging assessment of predictive risk factors associated with intraoperative massive hemorrhage in intracranial solid hemangioblastoma.

Quant Imaging Med Surg 2019 Nov;9(11):1781-1791

Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Background: A solid hemangioblastoma (SH) is a benign and highly vascularized tumor. Microsurgical treatment of SH is still challenging due to excessive intraoperative bleeding.

Methods: Sixty-six consecutive patients with SH were retrospectively analyzed. Read More

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November 2019

Central nervous system hemangioblastomas in the elderly (over 65 years): Clinical characteristics and outcome analysis.

Clin Neurol Neurosurg 2020 02 25;189:105622. Epub 2019 Nov 25.

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address:

Objectives: Hemangioblastomas (HBs) in the elderly are very uncommon and have rarely been studied. This retrospective study aimed to identify clinical features, optimal treatment, surgical outcomes and long-term prognostic factors in these rare lesions.

Patients And Methods: We performed a retrospective analysis of HBs patients over 65 years old who underwent surgery from 2008 to 2018 at our department. Read More

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February 2020

Hemangioblastoma arising from duramater: Case report.

Medicine (Baltimore) 2019 Nov;98(47):e18076

Department of Radiology, First Hospital of Jilin University.

Rationale: Hemangioblastoma (HB) is a benign tumor that is typically located in the subtentorial region of the brain. HB that originates from dura mater is extremely rare.

Patient Concerns: Herein, we reported a single case of a patient who presented with dizziness and headache lasting for 1 year that progressively aggravated within 1 month. Read More

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November 2019

Application of 3D-Printed Craniocerebral Model in Simulated Surgery for Complex Intracranial Lesions.

World Neurosurg 2020 Feb 8;134:e761-e770. Epub 2019 Nov 8.

Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, P. R. China.

Objective: To demonstrate the use of 3-dimensional (3D)-printed intracranial lesion models for complex neurosurgery to increase the success rate of clinical surgeries via practice in simulated surgeries.

Methods: We collected computed tomographic, magnetic resonance (MR), and computed tomographic images from patients with intracranial tumor or aneurysm, conducted multimodal image reconstruction, and then constructed a 3D-printed model with the skull base, cerebral arteries, and brain tumor or aneurysm. Forty-nine simulated surgeries were carried out on the model under a microscope, and actual surgery was carried out after validation and accumulation of experience. Read More

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February 2020

The Diagnostic Value of MRI-Based Texture Analysis in Discrimination of Tumors Located in Posterior Fossa: A Preliminary Study.

Front Neurosci 2019 23;13:1113. Epub 2019 Oct 23.

Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Objectives: To investigate the diagnostic value of MRI-based texture analysis in discriminating common posterior fossa tumors, including medulloblastoma, brain metastatic tumor, and hemangioblastoma.

Methods: A total number of 185 patients were enrolled in the current study: 63 of them were diagnosed with medulloblastoma, 56 were diagnosed with brain metastatic tumor, and 66 were diagnosed with hemangioblastoma. Texture features were extracted from contrast-enhanced T1-weighted (T1C) images and fluid-attenuation inversion recovery (FLAIR) images within two matrixes. Read More

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October 2019

Microsurgical Resection of Intraspinal Benign Tumors Using Non-Expansile Tubular Access.

World Neurosurg 2020 Jan 7;133:e97-e104. Epub 2019 Sep 7.

Spine Clinic, The American-British Cowdray Medical Center I.A.P. Campus Santa Fe, Mexico City, Mexico; National Autonomous University of Mexico, Mexico City, Mexico; Regional General Hospital #25 of the National Institute of Social Security, Mexico City, Mexico; Department of Neurology, Medicine School, University of Sonora, Obregon City, Mexico. Electronic address:

Background: Intraspinal tumors are 10 to 15 times less common than brain tumors. The midline approach with extensive laminectomies represents the current gold-standard for resection, causing instability, muscle damage, and kyphosis among other well-known complications. Minimally invasive series reported their results using retractor-based systems. Read More

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January 2020

Navigated 3-Dimensional Intraoperative Ultrasound for Spine Surgery.

World Neurosurg 2019 Nov 31;131:e155-e169. Epub 2019 Jul 31.

Department of Neurosurgery, University Marburg, Marburg, Germany.

Objective: To integrate 3-dimensional (3D) intraoperative ultrasound (iUS) data in spinal navigation.

Methods: In 11 patients with intradural spinal tumors, 3D-iUS was performed before and after tumor resection. Intraoperative computed tomography (iCT) was used for automatic patient registration for spinal navigation; fiducial-based registration was performed in 1 case. Read More

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November 2019

Augmented reality in intradural spinal tumor surgery.

Acta Neurochir (Wien) 2019 10 12;161(10):2181-2193. Epub 2019 Jul 12.

Department of Neurosurgery, University Marburg, Baldingerstrasse, 35033, Marburg, Germany.

Background: Microscope-based augmented reality (AR) is commonly used in cranial surgery; however, until recently, this technique was not implemented for spinal surgery. We prospectively investigated, how AR can be applied for intradural spinal tumor surgery.

Methods: For ten patients with intradural spinal tumors (ependymoma, glioma, hemangioblastoma, meningioma, and metastasis), AR was provided by head-up displays (HUDs) of operating microscopes. Read More

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October 2019

Unilateral Occipital Transtentorial Approach with Multimodal Assistance for Resection of Large Supracerebellar Hemangioblastomas: Preliminary Experience of 2 Cases.

World Neurosurg 2019 Sep 13;129:e733-e740. Epub 2019 Jun 13.

Department of Neurological Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: The surgical resection of large supracerebellar hemangioblastomas (SHBs) is exceptionally challenging due to their vascularity and deep anatomic location and is associated with a high risk of postoperative complications and mortality. Access to the posterior incisural space can be achieved by either an infratentorial supracerebellar approach or occipital transtentorial approach (OTA). However, the optimal surgical strategy has not yet been established. Read More

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September 2019

Contrast-Enhanced Ultrasonography and Color Doppler: Guided Intraoperative Embolization of Intracranial Highly Vascularized Tumors.

World Neurosurg 2019 Aug 25;128:547-555. Epub 2019 May 25.

Institute of Neurosurgery, Catholic University of Rome, Rome, Italy; Neurosurgical Unit, Mater Olbia Hospital, Olbia, Italy. Electronic address:

Background: Preoperative embolization is often considered mandatory in highly vascularized brain tumors to contain blood loss. However, not all lesions are amenable to endovascular preoperative embolization. In the literature, cases of preoperative and intraoperative embolization are described only by arterial catheterization, whereas experiences of tumor embolization through direct puncture of the lesion are anecdotal; furthermore these cases lack an intraoperative control method to assess the effects of the embolizing procedure itself. Read More

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Cerebellar Metastasis of Unknown Primary Neuroendocrine Carcinoma: Report of Case Mimicking Hemangioblastoma.

World Neurosurg 2019 Aug 21;128:320-323. Epub 2019 May 21.

Department of Neurosurgery, Seirei Hamamatsu General Hospital, Nakaku, Hamamatsu, Shizuoka, Japan.

Background: Neuroendocrine carcinoma (NEC) originates with neuroendocrine cells and is mainly found in the pancreas, lungs and gastrointestinal tract. We surgically treated a case of primary unknown NEC with only cerebral metastasis that mimicked hemangioblastoma. Recurrence was seen at the fornix, and no primary lesion had been identified as of 2 years after treatments despite careful examination. Read More

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A 50-Year-Old Male With A Hypothalamic Mass.

Brain Pathol 2019 05;29(3):455-456

Department of Neurosurgery, Military Institute of Medicine, Warsaw, Poland.

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Distal Outflow-Related Anterior Inferior Cerebellar Artery Aneurysm in Hemangioblastoma.

World Neurosurg 2019 Jul 12;127:284-288. Epub 2019 Apr 12.

Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Stroke Center, Sapporo Teishinkai Hospital, Hokkaiido, Japan. Electronic address:

Anterior inferior cerebellar artery (AICA) aneurysm is a rare cerebral entity, and its presentation in association with a hypervascularized tumor is even more exceptional. In this study, we describe a patient with rare coexistent pathologic conditions in combination with a cerebellar hypervascularized tumor with an outflow-related AICA aneurysm. A 1-stage procedure to remove both lesions was carried out after meticulous discussion with patient. Read More

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Metastatic Renal Cell Carcinoma to the Brain: A Contemporary Clinicopathologic Analysis With Comparison of Immunohistochemical Profiles to Selected Primary Brain Tumors With Clear Cell Features.

Appl Immunohistochem Mol Morphol 2020 May/Jun;28(5):395-402

Departments of Pathology.

Brain metastases from renal cell carcinoma (RCC) are associated with significant morbidity and mortality. However, there are only few large series in the pathology literature specifically analyzing the clinicopathologic and immunohistochemical features in comparison with primary brain tumors with clear cell features. We identified 34 cases of metastatic RCC to the brain from the Urologic Pathology and Neuropathology files of 2 institutions between 2000 and 2018. Read More

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Dysphagia: an unusual presentation of Von Hippel-Lindau disease.

Postgrad Med J 2019 Apr 30;95(1122):223. Epub 2019 Jan 30.

Department of Endocrinology, Post Graduate Institute for Medical Education and Research, Chandigarh, India

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The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas.

Pol J Radiol 2018 10;83:e197-e203. Epub 2018 May 10.

Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Purpose: Haemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.

Material And Methods: The study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. Read More

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A Rare Complication of Endovascular Embolization: Extruded Onyx on Trigeminal Nerve.

J Neurol Surg B Skull Base 2018 Dec 25;79(Suppl 5):S422-S423. Epub 2018 Sep 25.

Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States.

 To demonstrate a rare complication of endovascular tumor embolization with onyx.  Operative video.  Department of neurological surgery in a university hospital. Read More

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December 2018

Retromedullary Hemangioblastoma Mimicking a Posterior Inferior Cerebellar Artery Aneurysm: Case Report and Literature Review.

World Neurosurg 2019 Feb 4;122:165-170. Epub 2018 Nov 4.

Texas A&M College of Medicine, Temple, Texas, USA; Department of Neurosurgery, Baylor Scott and White Health, Temple, Texas, USA. Electronic address:

Background: Hemangioblastomas (HBMs) are benign vascular neoplasms that most commonly arise within the cerebellum. Although other vascular lesions should be considered in the differential diagnosis, HBMs rarely resemble aneurysms on neuroimaging and only 1 case of a cerebellar HBM mimicking a posterior fossa aneurysm has been reported. Here we describe a retromedullary HBM that masqueraded as a distal posterior inferior cerebellar artery (PICA) medullary branch aneurysm. Read More

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February 2019

The Application of FLOW 800 ICG Videoangiography Color Maps for Neurovascular Surgery and Intraoperative Decision Making.

World Neurosurg 2019 Feb 5;122:e186-e197. Epub 2018 Oct 5.

Department of Neurological Surgery, Goodman Campbell Brain and Spine and Indiana University, Indianapolis, Indiana, USA. Electronic address:

Background: Indocyanine green (ICG) videoangiography can assess cerebral blood flow, but results are primarily qualitative. FLOW 800 software measures fluorescence dynamics and creates a semiquantitative color delay map for assessment of relative sequence of blood flow within the vasculature.

Methods: We retrospectively reviewed 23 consecutive patients for whom FLOW 800 ICG videoangiography was used. Read More

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February 2019