1,551 results match your criteria Brain Imaging in Cavernous Angiomas


Multiple cerebral cavernous malformations in association with a Dubowitz-like syndrome.

J Cerebrovasc Endovasc Neurosurg 2020 Mar 31;22(1):15-19. Epub 2020 Mar 31.

Department of Neurosurgery, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Trust, Preston, PR2 9HT, UK.

Cerebral cavernous malformations (CCMs) are proliferative sinusoidal vascular lesions and are the most common vascular malformations of the brain. They can occur sporadically or secondary to an underlying genetic predisposition where multiple lesions are commonly seen. Dubowitz syndrome is a clinically-diagnosed rare genetic disorder with an unknown molecular basis. Read More

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http://dx.doi.org/10.7461/jcen.2020.22.1.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307612PMC

Removal of Double Cavernous Angioma of the Frontal Lobe using a Three-Dimensional Printed Model: A Case Report.

J UOEH 2020 ;42(2):217-222

Department of Neurosurgery, School of Medicine, University of Occupational and Environmental Health, Japan.

Cerebral cavernous angiomas are vascular anomalies with dilated spaces. We report the case of rare double cavernous angiomas causing higher brain dysfunction. A 74-year-old man exhibited cognitive dysfunction. Read More

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http://dx.doi.org/10.7888/juoeh.42.217DOI Listing
January 2020

Brain cavernous hemangioma mimicking radiation-induced necrosis in a patient with non-small cell lung cancer.

Thorac Cancer 2020 Jul 29;11(7):2056-2058. Epub 2020 May 29.

Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.

In patients with non-small cell lung cancer (NSCLC), stereotactic radiotherapy (SRT) is one of the standard therapies for those suffering with intracranial metastatic NSCLC. Radiation-induced necrosis (RIN) sometimes occurs as the result of the delayed effects of SRT. The magnetic resonance imaging (MRI) of RIN typically shows hypointense and hyperintense lesions on T1- and T2-weighted images, respectively. Read More

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http://dx.doi.org/10.1111/1759-7714.13494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327904PMC
July 2020
1.126 Impact Factor

Cerebral vascular malformations and their imaging modalities.

Neurol Sci 2020 Apr 25. Epub 2020 Apr 25.

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

Cerebrovascular malformations are uncommon diverse group of dysmorphic vascular communications that may occur sporadically or as part of genetic syndromes. These include non-neoplastic lesions such as arteriovenous malformations (AVM), cavernous malformations (CM), developmental venous anomalies (DVA), and telangiectasias as well as others like arteriovenous fistulas (AVF), vein of Galen malformations (VOGM), and mixed or unclassified angiomas. These lesions often carry a high degree of morbidity and mortality often requiring surgical or endovascular interventions. Read More

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http://dx.doi.org/10.1007/s10072-020-04415-4DOI Listing

Dumbbell shaped craniorbital cavernous hemangioma.

BMC Neurol 2020 Apr 22;20(1):149. Epub 2020 Apr 22.

Department of Neurosurgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, Hubei, China.

Background: Cavernous hemangioma of the orbit is a benign tumor mostly located behind the eye globe, but it rarely spread into the brain, which is called cerebral cavernous malformation as well, the lesion in the brain is irregular and enlarged blood. Here we report one particular case of craniorbital cavernous hemangioma.

Case Presentation: A 53-year-old woman presented with exophthalmos of the right eye and reduced vision. Read More

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http://dx.doi.org/10.1186/s12883-020-01734-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175531PMC

Medical monitoring of patient with cavernous hemangioma of the retina and intracranial involvement.

Am J Ophthalmol Case Rep 2020 Mar 27;17:100602. Epub 2020 Jan 27.

Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil.

Purpose: To describe a case report of Cavernous Hemangioma of the Retina (CHR) and highlight the importance of investigating intracranial system when retinal vascular alterations are present.

Observations: Patient of 26 years old, with right eye fundus alteration since 7 years old, no visual complaint. In the exam, there were sacular lesions with hematic content in the macula, configurating liquid level, associated with whitish lesion suggestive of fibrosis, compatible with cavernous hemangioma; best visual accuity of 20/20 both eyes. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7019121PMC

Too Much on Your "Plate"? Spectrum of Pathologies Involving the Tectal Plate.

Can Assoc Radiol J 2020 May 27;71(2):186-194. Epub 2020 Jan 27.

Department of Radiology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

The tectal plate comprises the posterior portion of the midbrain, borders the quadrigeminal cistern, and includes the superior and inferior colliculi. Benign and malignant pathologies occurring in this location may lead to aqueductal stenosis, obstructive hydrocephalus, and Parinaud syndrome. Both computed tomography and magnetic resonance imaging can be used to further characterize lesions involving the tectal plate. Read More

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http://dx.doi.org/10.1177/0846537119888410DOI Listing

Prevalence, risk factors and pregnancy outcomes of women with vascular brain lesions in pregnancy.

Arch Gynecol Obstet 2020 03 14;301(3):665-670. Epub 2020 Feb 14.

Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada.

Background: Vascular brain lesions (VBL) occur in up to 4.0% of the general population. With the increasing availability and use of sophisticated imaging techniques, there are more patients being diagnosed with asymptomatic intracranial AVMs and cavernous hemangiomas. Read More

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http://dx.doi.org/10.1007/s00404-020-05451-3DOI Listing

Rare case of giant pediatric cavernous angioma of the temporal lobe: A case report and review of the literature.

Surg Neurol Int 2020 10;11. Epub 2020 Jan 10.

Department of Neurosurgery, Cheikh Zaid International University Hospital, Abulcasis International University of Health Sciences, Rabat, Morocco.

Background: Giant cavernous malformations of the central nervous system are quite rare. They are more common in children and may be misdiagnosed as other intracranial neoplasms. Here, we presented a very rare giant cavernous angioma mimicking a neoplastic temporal lobe lesion in an 18-month-old male. Read More

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http://dx.doi.org/10.25259/SNI_468_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969371PMC
January 2020

Cerebrofacial venous metameric syndrome-spectrum of imaging findings.

Neuroradiology 2020 Apr 14;62(4):417-425. Epub 2020 Jan 14.

Division of Neuroradiology, Joint Department of Medical Imaging, Toronto Western Hospital, UHN, University of Toronto, Toronto, Ontario, Canada.

Cerebrofacial venous metameric syndrome (CVMS) is a complex craniofacial vascular malformation disorder in which patients have a constellation of venous vascular malformations affecting soft tissues, bone, dura, and neural structures including the eye and brain. It is hypothesized that a somatic mutation responsible for the venous abnormalities occurred prior to migration of the neural crest cells, and because of this, facial, osseous, and cerebral involvement typically follows a segmental or "metameric" distribution. The most commonly recognized form of CVMS is Sturge-Weber syndrome. Read More

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http://dx.doi.org/10.1007/s00234-020-02362-7DOI Listing

Sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage - case report.

BMC Ophthalmol 2019 Dec 16;19(1):259. Epub 2019 Dec 16.

Department of Ophthalmology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita-ku, Sapporo, 060-8638, Japan.

Background: We report a rare case of sudden bilateral vision loss due to third ventricular cavernous angioma with intratumoral hemorrhage.

Case Presentation: A 45-year-old woman presented decreased visual acuity in both eyes. Her best corrected visual acuity was 0. Read More

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http://dx.doi.org/10.1186/s12886-019-1252-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6916187PMC
December 2019

Vertebral Intraosseous Vascular Malformations in a Familial Cerebral Cavernous Malformation Population: Prevalence, Histologic Features, and Associations With CNS Disease.

AJR Am J Roentgenol 2020 02 11;214(2):428-436. Epub 2019 Dec 11.

Department of Radiology, University of New Mexico Health Sciences Center, 1 University of New Mexico, MSC 10 5530, Albuquerque, NM 87131.

The purpose of this study was to investigate whether MRI-typical and MRI-atypical intraosseous vascular malformations are associated with familial cerebral cavernous malformation (FCCM). In a retrospective matched case-control study, two radiologists reviewed the spinal imaging, both CT and MRI, of 22 patients with FCCM seen between 2006 and 2017 and of age- and sex-matched control subjects for MRI-typical and MRI-atypical intraosseous vascular malformations. Quantitative analysis of lesions identified included vertebral level, size, and number of lesions. Read More

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http://dx.doi.org/10.2214/AJR.19.21492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299190PMC
February 2020

Anterior Petrosectomy for Resection of Brainstem Cavernous Malformation.

World Neurosurg 2020 03 29;135. Epub 2019 Nov 29.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Brainstem cavernous malformations are uncommon vascular lesions that require complex surgical approaches. The case described in this video involved a 23-year-old male who presented with repeated, symptomatic episodes of bleeding of pontomedullary cavernous malformation, which was resected. The anterior petrosectomy approach is detailed in Video 1, highlighting middle fossa triangles and their boundaries, as well as important safety techniques. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.11.138DOI Listing

Application of 3D-Printed Craniocerebral Model in Simulated Surgery for Complex Intracranial Lesions.

World Neurosurg 2020 Feb 8;134:e761-e770. Epub 2019 Nov 8.

Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Beijing, P. R. China.

Objective: To demonstrate the use of 3-dimensional (3D)-printed intracranial lesion models for complex neurosurgery to increase the success rate of clinical surgeries via practice in simulated surgeries.

Methods: We collected computed tomographic, magnetic resonance (MR), and computed tomographic images from patients with intracranial tumor or aneurysm, conducted multimodal image reconstruction, and then constructed a 3D-printed model with the skull base, cerebral arteries, and brain tumor or aneurysm. Forty-nine simulated surgeries were carried out on the model under a microscope, and actual surgery was carried out after validation and accumulation of experience. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.191DOI Listing
February 2020
5 Reads

Improving the Accuracy of Neuronavigation in Cerebral Cavernous Malformation: A Technical Note on 68 Cases.

Surg Technol Int 2019 11;35:447-454

Institute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, Rome, Italy, Department of Neurosurgery, Mater Olbia Hospital, Olbia, Italy.

Cavernous malformations (CM) are benign, low-flow vascular lesions that account for 5% - 13% of all cerebrovascular malformations. Surgery remains the most important treatment strategy, and many different approaches have been developed. We present here our institutional experience with 68 cases using a transcortical neuronavigation approach with some technical nuances to improve navigation accuracy during resection. Read More

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November 2019

Microsurgical Resection of Recurrent Cavernous Sinus Hemangioma by Superior and Lateral Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2019 Nov 5. Epub 2019 Nov 5.

Department of Neurosurgery, University of Washington, Seattle, Washington.

This video shows the technical nuances of microsurgical resection of recurrent cavernous sinus (CS) hemangioma by superior and lateral approach.  A 77-yr-old woman presented with headache and difficulty in vision in right eye for 6 mo. She had previously undergone attempted resection of a right CS tumor in another hospital with partial removal, and the tumor had grown significantly. Read More

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http://dx.doi.org/10.1093/ons/opz313DOI Listing
November 2019

Nontraumatic Pediatric Intracerebral Hemorrhage.

Stroke 2019 12 22;50(12):3654-3661. Epub 2019 Oct 22.

From the Pediatric Radiology Department, Necker Enfants Malades (NEM), INSERM UMR1266, Sainte-Anne (G.B., J.F.H., O.N.).

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http://dx.doi.org/10.1161/STROKEAHA.119.025783DOI Listing
December 2019
1 Read

Predictors of Initial Presentation with Hemorrhage in Patients with Cavernous Malformations.

World Neurosurg 2020 Jan 9;133:e767-e773. Epub 2019 Oct 9.

Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA.

Background: Cavernous malformations (CMs) are low-flow vascular malformations of the central nervous system which are incidental or present with hemorrhage, seizures, or focal neurologic deficit (FND). Little is known about the time course of symptoms and the predictors of initial hemorrhagic presentation.

Methods: Beginning in 2015, consecutive patients with radiologically confirmed CMs were recruited and completed a structured interview and written survey at baseline. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.09.161DOI Listing
January 2020
1 Read

Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations.

Circ Res 2019 10 9;125(10):e43-e54. Epub 2019 Sep 9.

From the Department for Animal Physiology, Institute of Biochemistry and Biology, Potsdam University, Germany (C.J.R., C.O., S.D., M.L., D.F., A.P., S.A.-S.).

Rationale: Pathological biomechanical signaling induces vascular anomalies including cerebral cavernous malformations (CCM), which are caused by a clonal loss of CCM1/KRIT1 (Krev interaction trapped protein 1), CCM2/MGC4607, or CCM3/PDCD10. Why patients typically experience lesions only in lowly perfused venous capillaries of the cerebrovasculature is completely unknown.

Objective: In contrast, animal models with a complete loss of CCM proteins lack a functional heart and blood flow and exhibit vascular anomalies within major blood vessels as well. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.119.315076DOI Listing
October 2019
1 Read

Intraoperative Resting-State Functional Connectivity and Resting-State Networks in Patients with Intracerebral Lesions: Detectability and Variations Between Sessions.

World Neurosurg 2020 Jan 3;133:e197-e204. Epub 2019 Sep 3.

International Neuroscience Institute, Department of Neurosurgery, Hannover, Germany; Leibniz Institute for Neurobiology, Magdeburg, Germany.

Objective: To evaluate the functional connectivity (FC) and resting-state networks (RSNs) in patients under anesthesia operated for resection of intracerebral lesions.

Methods: We performed intraoperative resting-state functional magnetic resonance imaging (irs-fMRI) in 24 patients under anesthesia before and after lesion resection. Correlation matrices were established for each session (a total 48 of sessions). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.188DOI Listing
January 2020

Intraaxial and Extraaxial Cavernous Malformation with Venous Linkage: Immune Cellular Inflammation Associated with Aggressiveness.

World Neurosurg 2019 Nov 26;131:87-89. Epub 2019 Jul 26.

Department of Pathology, Federal University of Rio de Janeiro, HUCFF, and Graduate Program of Pathology, Rio de Janeiro, Brazil; Neurodegeneration and Repair Laboratory, UFRJ, Rio de Janeiro, Brazil.

Background: Intraorbital and intracerebral cavernous malformation (CM) lesions are considered independent entities. Purely cerebral CMs have variable biology with recent evidence depicting inflammation as an important player and a risk factor for aggressiveness. We describe a case of concomitant left intraaxial and extraaxial CMs, linked by the ipsilateral basal vein, where the extraaxial component has developed an aggressive behavior. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.145DOI Listing
November 2019

Intramedullary Cavernous Hemangioma with Calcification of Spinal Cord.

World Neurosurg 2019 Oct 12;130:298-303. Epub 2019 Jul 12.

Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background: A 61-year-old man was admitted complaining of myelopathy and back pain for 3 months.

Case Description: A 15-mm hemangioma with calcification was noted on magnetic resonance imaging and computed tomography. Intraoperatively, the mass was hard with ill-defined demarcation. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.07.061DOI Listing
October 2019
6 Reads

Repeat Resection of a Cavernous Malformation of the Optic Nerve/Chiasm via a Frontotemporal Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 May;18(5):E169-E170

Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.

Cavernous malformations are benign vascular lesions that can arise throughout the central nervous system. The occurrence of a cavernous malformation within the optic nerve or chiasm, however, is extremely uncommon. The case described in this video involved a 36-yr-old woman who presented 3 mo after undergoing a left frontotemporal craniotomy for resection of an optic nerve cavernous malformation. Read More

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http://dx.doi.org/10.1093/ons/opz183DOI Listing
May 2020
2 Reads

Left atrial cavernous haemangioma presenting with cardiac tamponade in a patient with Cowden syndrome.

BMJ Case Rep 2019 Jul 8;12(7). Epub 2019 Jul 8.

Department of Anaesthesia, Austin Health, Heidelberg, Victoria, Australia.

Cowden syndrome (CS) is a rare disorder characterised by multiple non-cancerous, tumour-like growths called hamartomas. The syndrome is associated with the development of cancer of the breast, endometrium, kidneys, skin and rarely the brain. We report a rare case of symptomatic cardiac haemangioma in a patient with CS. Read More

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http://dx.doi.org/10.1136/bcr-2019-229741DOI Listing
July 2019
1 Read

Cavernous angiomas: deconstructing a neurosurgical disease.

J Neurosurg 2019 Jul;131(1):1-13

Cavernous angioma (CA) is also known as cavernoma, cavernous hemangioma, and cerebral cavernous malformation (CCM) (National Library of Medicine Medical Subject heading unique ID D006392). In its sporadic form, CA occurs as a solitary hemorrhagic vascular lesion or as clustered lesions associated with a developmental venous anomaly. In its autosomal dominant familial form (Online Mendelian Inheritance in Man #116860), CA is caused by a heterozygous germline loss-of-function mutation in one of three genes-CCM1/KRIT1, CCM2/Malcavernin, and CCM3/PDCD10-causing multifocal lesions throughout the brain and spinal cord. Read More

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https://thejns.org/view/journals/j-neurosurg/131/1/article-p
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http://dx.doi.org/10.3171/2019.3.JNS181724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778695PMC
July 2019
5 Reads

Cerebral Small Vessel Disease Biomarkers Detection on MRI-Sensor-Based Image and Deep Learning.

Sensors (Basel) 2019 Jun 6;19(11). Epub 2019 Jun 6.

Department of Medical Imaging, Taipei Medical University Hospital, Taipei City 110, Taiwan.

Magnetic resonance imaging (MRI) offers the most detailed brain structure image available today; it can identify tiny lesions or cerebral cortical abnormalities. The primary purpose of the procedure is to confirm whether there is structural variation that causes epilepsy, such as hippocampal sclerotherapy, local cerebral cortical dysplasia, and cavernous hemangioma. Cerebrovascular disease, the second most common factor of death in the world, is also the fourth leading cause of death in Taiwan, with cerebrovascular disease having the highest rate of stroke. Read More

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http://dx.doi.org/10.3390/s19112573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6603587PMC
June 2019
4 Reads

CCM1/KRIT1 mutation in monozygotic twins of a polyzygotic triplet birth: genetic, clinical and radiological characteristics.

Neurosurg Rev 2019 Sep 6;42(3):765-768. Epub 2019 Jun 6.

Department of Neurosurgery, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.

Cerebral cavernous malformations are focal vascular lesions of the brain, occurring sporadically or as an autosomal dominant familial form. The genetic background influences not only the clinical course but also patients' consultation and the indication to treat. We here present the rare case of monozygotic male twins of a polyzygotic triplet birth, carrying a CCM1 mutation, inherited from the mother. Read More

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http://dx.doi.org/10.1007/s10143-019-01124-1DOI Listing
September 2019
1 Read

Visual Diagnosis: Acute-Onset Headache, Vertigo, and Torsional Nystagmus in a 13-year-old Boy.

Pediatr Rev 2019 Jun;40(6):e22-e24

Department of Neurology, Children's Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, MI.

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http://dx.doi.org/10.1542/pir.2017-0164DOI Listing
June 2019
6 Reads

Ipsilateral brain cavernoma under scleroderma plaque: a case report.

Pan Afr Med J 2019 8;32:13. Epub 2019 Jan 8.

Neurosurgery Department St Michael's Hospital, Toronto, Ontario, Canada.

Scleroderma is a rare disease of unknown etiology, which is characterized by thickening and hardening of skin due to an increased collagen production. A 44-year-old female patient with a scleroderma on the scalp known by our department, also presented an ipsilateral brain lesion since 2015, which was showing growth without any clinical symptomatology and the patient wanted the lesion to be removed. This atypical lesion underneath the scleroderma shows that diagnosis can be missed without brain imaging and biopsy. Read More

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http://dx.doi.org/10.11604/pamj.2019.32.13.15288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522175PMC
June 2019
28 Reads

Leksell Stereotactic Radiosurgery for Cavernous Malformations.

Prog Neurol Surg 2019 16;34:260-266. Epub 2019 May 16.

Departments of Neurosurgery and Radiation Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Cavernous malformations (CM) represent a distinct subgroup of brain vascular malformations that are characterized by small sinusoidal vascular channels with hyaline degeneration and old blood pigments. Because of the increasing availability of magnetic resonance imaging (MRI) they are detected much more frequently in the present era. CM may be solitary or found in the context of a familial variant that results in an increasing number of CM developing as the patient ages. Read More

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https://www.karger.com/Article/FullText/493072
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http://dx.doi.org/10.1159/000493072DOI Listing
December 2019
21 Reads

Neurovascular Lesions in Pediatric Epilepsy.

J Child Neurol 2019 09 8;34(10):549-555. Epub 2019 May 8.

1 Division of Pediatric Neurology, University of Alberta, Edmonton, Alberta, Canada.

Introduction: Neurovascular lesions are rare and understudied in the pediatric population. Their initial presentation can range from seizures to focal neurologic deficits, as well as headaches. The goal of this study was to examine the clinical presentation and natural history of neurovascular lesions in children with epilepsy. Read More

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http://dx.doi.org/10.1177/0883073819838445DOI Listing
September 2019
17 Reads

Pontine cavernoma haemorrhage at 24 weeks of pregnancy that resulted in eight-and-a-half syndrome.

Acta Neurol Belg 2019 Sep 29;119(3):471-474. Epub 2019 Apr 29.

Department of Neurosurgery, University of Medicine and Pharmacy Targu Mures, Targu Mures, Romania.

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http://dx.doi.org/10.1007/s13760-019-01147-xDOI Listing
September 2019
4 Reads

Atypical Presentation of Parietal Convexity Dural-Based Cavernous Hemangioma: A Case Report and Review of Literature.

World Neurosurg 2019 Aug 19;128:403-407. Epub 2019 Apr 19.

Neurosurgery Department, Saint Joseph Hospital, Beirut, and Faculty of Medicine-Saint Joseph University, Achrafieh, Lebanon. Electronic address:

Background: Dural presentation of a cavernous hemangioma is a rare occurrence. Classically an intraparenchymal lesion with varying symptomatology including mostly headaches, seizures, and neurologic deficits depending on its location, a few cases have been reported along the convexity of the brain, even less eroding the calvaria, with none occasioning abnormal movements as the initial presentation.

Case Description: This is a case of a 67-year-old male who presented to the clinic for atypical progressive choreiform movements of the right side of his body and a soft subgaleal mass. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.119DOI Listing
August 2019
4 Reads

Surgical resection of cavernous angioma located within eloquent brain areas: International survey of the practical management among 19 specialized centers.

Seizure 2019 Jul 28;69:31-40. Epub 2019 Mar 28.

Department of Neurosurgery, Sainte-Anne Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France; UMR 1266 INSERM, IMA-BRAIN, Institute of Psychiatry and Neurosciences of Paris, Paris, France. Electronic address:

Purpose: The practical management of cavernous angioma located within eloquent brain area before, during and after surgical resection is poorly documented. We assessed the practical pre-operative, intra-operative, and post-operative management of cavernous angioma located within eloquent brain area.

Method: An online survey composed of 61 items was sent to 26 centers to establish a multicenter international retrospective cohort of adult patients who underwent a surgical resection as the first-line treatment of a supratentorial cavernous angioma located within or close to eloquent brain area. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.03.022DOI Listing
July 2019
18 Reads

Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas.

Neurosurgery 2019 10;85(4):E702-E713

Department of Neurosurgery, Sainte-Anne Hospital, Paris, France.

Background: The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area.

Objective: To assess the predictors of preoperative seizure control, postoperative seizure control, and postoperative ability to work, and the safety of the surgery.

Methods: Multicenter international retrospective cohort analysis of adult patients benefitting from a functional-based surgical resection with intraoperative functional brain mapping for a supratentorial CA within or close to eloquent brain areas. Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyz063DOI Listing
October 2019
33 Reads

Familial Cerebral Cavernous Malformations.

Stroke 2019 05;50(5):1294-1301

From the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.

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http://dx.doi.org/10.1161/STROKEAHA.118.022314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924279PMC
May 2019
7 Reads
5.723 Impact Factor

Klippel-Trenaunay-Weber Syndrome with Atypical Presentation of Cerebral Cavernous Angioma: A Case Report and Literature Review.

World Neurosurg 2019 Jun 21;126:354-358. Epub 2019 Mar 21.

Department of Radiology, Mayo Clinic, Jacksonville, Florida, USA; Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA.

Background: Klippel-Trenaunay-Weber syndrome (KTWS) is a rare syndrome characterized by the triad of cutaneous hemangiomas, venous varicosities, and osseous-soft tissue hypertrophy of the affected limb. Clinical manifestations, genetic testing, and radiologic imaging are the key steps in diagnosing this syndrome.

Case Description: An 18-month-old boy was brought for follow-up brain magnetic resonance imaging (MRI) with a history of right lower limb hypertrophy, cutaneous varicosities, and hemangiomas diagnosed at birth. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.03.132DOI Listing
June 2019
15 Reads

Infratentorial Developmental Venous Abnormalities and Inflammation Increase Odds of Sporadic Cavernous Malformation.

J Stroke Cerebrovasc Dis 2019 Jun 14;28(6):1662-1667. Epub 2019 Mar 14.

Department of Neurology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Goal: Sporadic brain cavernous malformations commonly correlate with developmental venous anomalies; however, developmental venous anomalies may exist without cavernous malformations. Infratentorial location and specific angioarchitectural features of the developmental venous anomaly increase the odds of a concomitant malformation. Animal data also suggest chronic inflammatory disease, oxidative stress, and angiogenesis promote cavernous malformation development. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2019.02.025DOI Listing
June 2019
5 Reads

Hemorrhage, Seizures, and Dynamic Changes of Familial versus Nonfamilial Cavernous Malformation: Systematic Review and Meta-analysis.

World Neurosurg 2019 Jun 7;126:241-246. Epub 2019 Mar 7.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre for Biomedical Science, and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. Electronic address:

Background: Cerebral cavernous malformations (CCMs) may be familial or nonfamilial. This systematic review compared the natural history of CCMs in familial compared with nonfamilial cases.

Methods: We searched MEDLINE, Web of Science, and EMBASE for natural history studies on CCMs up to September 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193052
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http://dx.doi.org/10.1016/j.wneu.2019.02.115DOI Listing
June 2019
14 Reads

Cavernous Angioma Mimicking Meningioma.

J Craniofac Surg 2019 May/Jun;30(3):e218-e220

Department of Neurosurgery, Katip Celebi University Ataturk Training and Research Hospital.

The authors present a rare case of cavernous angioma mimicking a meningioma in a 58-year-old man who presented with a headache and dizziness. There were no neurological deficits or other neurological symptoms or signs. An extra-axial mass lesion thought to be associated with diffusely well-enhanced falx in the postcontrast sections was noted in the posterior interhemispheric fissure near the posterior part of the corpus callosum splenium. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005177DOI Listing
July 2019
8 Reads

Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.

Stroke 2019 03;50(3):738-744

From the Section of Neurosurgery (R.S., T.M., R.L., R.G., N.H., S.P.P., J.K., D.Z., S.B.L., Y.C., K.C., L.S., I.A.A.), Biological Sciences Division, University of Chicago, IL.

Background and Purpose- Previously, murine models Krit1 Msh2 and Ccm2 Trp53 showed a reduction or no effect on cerebral cavernous malformation (CCM) burden and favorable effects on lesional hemorrhage by the robust Rock (Rho-associated protein kinase) inhibitor fasudil and by simvastatin (a weak pleiotropic inhibitor of Rock). Herein, we concurrently investigated treatment of the more aggressive Pdcd10/Ccm3 model with fasudil, simvastatin, and higher dose atorvastatin to determined effectiveness of Rock inhibition. Methods- The murine models, Pdcd10 Trp53 and Pdcd10 Msh2 , were contemporaneously treated from weaning to 5 months of age with fasudil (100 mg/kg per day in drinking water, n=9), simvastatin (40 mg/kg per day in chow, n=11), atorvastatin (80 mg/kg per day in chow, n=10), or with placebo (n=16). Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.024058
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http://dx.doi.org/10.1161/STROKEAHA.118.024058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389370PMC
March 2019
17 Reads

Endoscopic Endonasal Surgery for the Resection of a Cavernous Hemangioma with a Sellar Extension.

Cureus 2018 Nov 30;10(11):e3663. Epub 2018 Nov 30.

Neurological Surgery, University of Louisville School of Medicine, Louisville, USA.

Cavernous hemangiomas with an intrasellar extension are very rare, generally benign lesions that manifest by the compression of nearby structures. The presenting symptoms usually range from visual disturbances to an endocrine imbalance. Occasional extension into the cavernous sinus has been reported, which can cause cranial nerve compression. Read More

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http://dx.doi.org/10.7759/cureus.3663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355302PMC
November 2018
7 Reads

Clinical Features, Intradural Transcavernous Surgical Management, and Outcomes of Giant Cavernous Sinus Hemangiomas: A Single-Institution Experience.

World Neurosurg 2019 05 5;125:e754-e763. Epub 2019 Feb 5.

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

Background: Cavernous sinus hemangiomas (CSHs) are rare vascular tumors. Stereotactic radiosurgery is an effective treatment for small CSHs. The optimal treatment for giant CSHs is controversial. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.165DOI Listing
May 2019
12 Reads
2.417 Impact Factor

Rare Pediatric Presentation of a Cavernous Angioma of the Septum Pellucidum.

Pediatr Neurosurg 2019 7;54(2):147-149. Epub 2019 Feb 7.

Department of Neurosurgery, Albany Medical College, Albany, New York, USA.

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http://dx.doi.org/10.1159/000496394DOI Listing
May 2019
1 Read

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
46 Reads

Analysis of Cavernous Malformations: Experience with 18 Cases.

Turk Neurosurg 2019 ;29(3):340-348

Klinik für Wirbelsaulen Chirurgie und Neurotraumatologie, Zwickau, Germany.

Aim: To analyze the results of stereotactic radiosurgery (SRS) or surgical treatment of 18 cases with cavernous malformation and report 2 cases with unusual localization and size.

Material And Methods: We present 11 and 8 patients who underwent surgery and SRS between 2010 and 2018 respectively. The operated group comprised six men and five women (mean age, 33. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.22645-18.2DOI Listing
October 2019
5 Reads

Surgical treatment of an asymptomatic giant supratentorial cavernous hemangioma. Case report.

J Clin Neurosci 2019 Apr 4;62:231-234. Epub 2019 Jan 4.

LINT, Facultad de Medicina, Universidad Nacional de Tucumán, Tucumán, Argentina; Chief of Department of Neurological Surgery, Hospital Padilla, Tucumán, Argentina.

A case is reported of a 19-year old patient with a supratentorial giant cavernous malformation (GCM). This was an incidental finding in the context of acute head trauma. Brain computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a giant supratentorial right mass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183205
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http://dx.doi.org/10.1016/j.jocn.2018.12.032DOI Listing
April 2019
5 Reads

Unusual etiology of bilateral acute visual impairment: Optochiasmatic cavernoma haemorrhage.

Am J Emerg Med 2019 03 14;37(3):564.e1-564.e4. Epub 2018 Dec 14.

Ophthalmology Department, Military Instruction Hospital Mohammed V, Rabat, Morocco.

Optochiasmatic cavernoma haemorrhage is unusual etiology of bilateral acute visual impairment. This vascular hamartoma is extremely rare with a prevalence rate of 0.4-0. Read More

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http://dx.doi.org/10.1016/j.ajem.2018.12.024DOI Listing
March 2019
3 Reads

Could propranolol be beneficial in adult cerebral cavernous malformations?

Neurosurg Rev 2019 Jun 4;42(2):403-408. Epub 2019 Jan 4.

Hospices Civils de Lyon, Neurology & Neurosurgery Hospital Pierre Wertheimer, Department of Neurosurgery, Lyon, France.

Surgery is the only therapeutic option for cerebral cavernous malformations (CCM) and is proposed, whenever possible, after haemorrhagic events, neurological symptoms, or epilepsy, radiosurgery being a controversial alternative in some cases. However, there is no treatment for non-accessible lesions, such as brainstem CCM, multiple CCM, or those located in functional areas. Propranolol, a non-selective beta-blocker used as first-line treatment for infantile haemangiomas, has proved spectacularly effective in a few cases of adult patients with CCM. Read More

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http://dx.doi.org/10.1007/s10143-018-01074-0DOI Listing
June 2019
2 Reads

Early onset cerebral amyloid angiopathy following childhood exposure to cadaveric dura.

Ann Neurol 2019 02 17;85(2):284-290. Epub 2019 Jan 17.

Stroke Research Centre, Department of Brain Repair and Rehabilitation, University College London Queen Square Institute of Neurology and National Hospital for Neurology and Neurosurgery, London.

Amyloid-β transmission has been described in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little information regarding the clinical impact of this acquired amyloid-β pathology during life. Here, for the first time, we describe in detail the clinical and neuroimaging findings in 3 patients with early onset symptomatic amyloid-β cerebral amyloid angiopathy following childhood exposure to cadaveric dura (by neurosurgical grafting in 2 patients and tumor embolization in a third). Our observations provide further in vivo evidence that cerebral amyloid angiopathy might be caused by transmission of amyloid-β seeds (prions) present in cadaveric dura and have diagnostic relevance for younger patients presenting with suspected cerebral amyloid angiopathy. Read More

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http://doi.wiley.com/10.1002/ana.25407
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http://dx.doi.org/10.1002/ana.25407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492172PMC
February 2019
30 Reads