1,693 results match your criteria Brain Imaging in Cavernous Angiomas

Histological quantification of cerebral cavernous malformations in the murine brain.

STAR Protoc 2022 Jun 9;3(2):101448. Epub 2022 Jun 9.

Vascular Biology Unit, The FIRC Institute of Molecular Oncology Foundation, Milan 20139, Italy.

In the study of cerebral cavernous malformations (CCMs), the quantification of lesion burden is the main parameter for evaluation of disease severity and efficacy of drugs. We describe a reliable and cost-effective protocol to evaluate the number and the size of vascular malformations in the murine brain. This approach is based on histology and confocal imaging and can be performed with standard laboratory equipment. Read More

View Article and Full-Text PDF

Long-Term Management of Seizures after Surgical Treatment of Supratentorial Cavernous Malformations : A Retrospective Single Centre Study.

J Korean Neurosurg Soc 2022 May 29;65(3):415-421. Epub 2022 Apr 29.

Department of Neurosurgery, Medical University of Warsaw, Warszawa, Poland.

Objective: Seizure recurrence after the first-ever seizure in patients with a supratentorial cerebral cavernous malformation (CCM) is almost certain, so the diagnosis and treatment of epilepsy is justified. The optimal method of management of these patients is still a matter of debate. The aim of our study was to identify factors associated with postoperative seizure control and assess the surgical morbidity rate. Read More

View Article and Full-Text PDF

A Chinese Family With Cerebral Cavernous Malformation Caused by a Frameshift Mutation of the Gene: A Case Report and Review of the Literature.

Front Neurol 2022 4;13:795514. Epub 2022 Apr 4.

Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.

Background: Familial cerebral cavernous malformation (FCCM) is a vascular malformation disease closely linked to three identified genes: and . Over the past decade, a few cases of cerebral cavernous malformation (CCM) caused by different gene mutations have been reported in Chinese families. Herein, we introduce a Chinese family affected by FCCM due to a kind of frameshift mutation. Read More

View Article and Full-Text PDF

Propranolol as therapy for cerebral cavernous malformations: a cautionary note.

J Transl Med 2022 04 5;20(1):160. Epub 2022 Apr 5.

Department of Neurological Surgery, University of Chicago Medicine and Biological Sciences, 5841 S. Maryland, MC 3026, Chicago, IL, 60637, USA.

View Article and Full-Text PDF

Thirteen-and-a-half Syndrome Secondary to the Brainstem Cavernoma.

Neurol India 2022 Jan-Feb;70(1):355-358

Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, Uttar Pradesh, India.

Background: "Thirteen-and-a-half" is a newly described clinical syndrome characterized by the combination of the one-and-a-half syndrome with fifth and seventh cranial nerve nuclei involvement (1 + 5 + 7 = 13). To the authors' knowledge, this is the first report of the thirteen-and-a-half syndrome secondary to pontine cavernoma and, overall, only the second reported case of this syndrome in the literature till date.

Case Report: A 20-year-old man presented with the clinical features suggestive of the thirteen-and-a-half syndrome, explained radiologically by pontine cavernoma. Read More

View Article and Full-Text PDF

Resection of Brainstem Cavernous Malformations: Pearls and Pitfalls for Minimizing Complications.

World Neurosurg 2022 Mar;159:390-401

The Neurosurgical Atlas, Carmel, Indiana, USA; Department of Neurological Surgery, Indiana University, Indianapolis, Indiana, USA. Electronic address:

Background: Surgical management of brainstem cavernous malformations (CMs) is a controversial topic in the field of neurosurgery. These lesions have a propensity to hemorrhage, thereby disrupting surrounding brainstem eloquence.

Methods: This article provides the personal reflections of the senior author and a narrative literature review on resection of brainstem CMs. Read More

View Article and Full-Text PDF

Acceleration of Brain Susceptibility-Weighted Imaging with Compressed Sensitivity Encoding: A Prospective Multicenter Study.

AJNR Am J Neuroradiol 2022 03 3;43(3):402-409. Epub 2022 Mar 3.

From the Department of Radiology (J.D., Y.D., Z.Z., L.G., F.Z., R.C., Y.L.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Background And Purpose: While three-dimensional susceptibility-weighted imaging has been widely suggested for intracranial vessel imaging, hemorrhage detection, and other neuro-diseases, its relatively long scan time has necessitated the clinical verification of recent progresses of fast imaging techniques. Our aim was to evaluate the effectiveness of brain SWI accelerated by compressed sensitivity encoding to identify the optimal acceleration factors for clinical practice.

Materials And Methods: Ninety-nine subjects, prospectively enrolled from 5 centers, underwent 8 brain SWI sequences: 5 different folds of compressed sensitivity encoding acceleration (CS2, CS4, CS6, CS8, and CS10), 2 different folds of sensitivity encoding acceleration (SF2 and SF4), and 1 without acceleration. Read More

View Article and Full-Text PDF

Hypothalamic Cavernous Malformation: Surgical Technique and Literature Review.

Cureus 2022 Jan 23;14(1):e21511. Epub 2022 Jan 23.

Neurosurgery, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MEX.

Hypothalamic cavernous malformation (HCM) is rare, and to our knowledge, there are only 28 cases reported in the literature. An 18-year-old male presented two years ago with a severe headache followed by right eye blindness. Following imaging studies, a bleeding hypothalamic cavernoma was discovered together with another incidental cavernoma in the brain. Read More

View Article and Full-Text PDF
January 2022

Evidences of PIEZO1 involvement in cerebral cavernous malformation pathogenesis.

Microvasc Res 2022 05 14;141:104342. Epub 2022 Feb 14.

Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, via Consolare Valeria 1, 98125 Messina, Italy; Department of Biomolecular Strategies, Genetics, Cutting-edge Therapies, I.E.ME.S.T., via Michele Miraglia 20, Palermo 90139, Italy.

View Article and Full-Text PDF

Cavernous malformations.

Jeremy C Ganz

Prog Brain Res 2022 6;268(1):115-132. Epub 2022 Jan 6.

Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway. Electronic address:

Cavernous malformations are relatively common intracerebral malformations of which we only became properly aware after the introduction of MRI. They may be sporadic or familial. Familial CMs may be multiple and new lesions appear over time requiring intermittent MR control. Read More

View Article and Full-Text PDF

Intraventricular Choroid Plexus Cavernoma Resection Using Tubular Retractor System and Exoscope Visualization: A Technical Case Report.

Oper Neurosurg (Hagerstown) 2022 03;22(3):e134-e137

Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, New York, USA.

Background And Importance: Cavernous malformations (CMs) account for approximately 5% to 10% of all CNS vascular malformations, and intraventricular CMs (IVCMs) are a rare subtype, accounting for 2.5% to 10.8% of all intracranial CMs. Read More

View Article and Full-Text PDF

Supracerebellar Transtentorial Approach for Posterior Temporomesial Cavernoma: 3-Dimensional Operative Video.

World Neurosurg 2022 Mar 1;159:109. Epub 2022 Jan 1.

Laboratory of Microsurgical Neuroanatomy, School of Medicine, University of Buenos Aires, Buenos Aires City, Argentina. Electronic address:

The temporomesial region is a frequent site of neurosurgical lesions such as tumors, cavernomas, or arteriovenous malformations. This region has been divided into 3 regions: anterior, middle, and posterior. The objective of Video 1 is to present the case of a posterior temporomesial cavernoma resection through a supracerebellar transtentorial approach, highlighting the surgical technique. Read More

View Article and Full-Text PDF

Giant Frontotemporal Cavernous Malformation in a 2-Month-Old Infant: A Case Report and Review of the Literature.

Pediatr Neurosurg 2022 8;57(1):56-62. Epub 2021 Nov 8.

Department of Neurosurgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Introduction: Cavernous malformations in the pediatric population are exceedingly rare, especially in infants. Giant cavernous malformations (GCM) are even more rare and have a diameter >4 cm. The onset of symptoms predominantly occurs in adulthood, but the rate of hemorrhage is significantly higher in the pediatric population. Read More

View Article and Full-Text PDF
February 2022

Cerebral proliferative angiopathy accompanied by cerebral cavernous malformation: A case report.

Clin Neurol Neurosurg 2021 11 28;210:107011. Epub 2021 Oct 28.

Interventional Neuroradiology Section, Radiology Department, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.

Cerebral Proliferative Angiopathy (CPA) is a rare vascular malformation that is distinguished from classical brain arteriovenous malformations (AVM) in its imaging findings and clinical progression but more importantly in its pathophysiology. Here we report the case of a 37-year-old male patient with CPA accompanied by Cerebral Cavernous Malformation (CCM) in hopes to expand the inquiry into the pathophysiology of this rare lesion. A patient with progressive headache, right-sided weakness, and impaired speech were evaluated at our medical center. Read More

View Article and Full-Text PDF
November 2021

Natural Course of Cerebral Cavernous Malformations in Children: A Five-Year Follow-Up Study.

Stroke 2022 03 28;53(3):817-824. Epub 2021 Oct 28.

Department of Neurosurgery and Spine Surgery (A.N.S., L.R., D.S., B.C., A.H., T.F.D., R.J., K.H.W., U.S., P.D.), University Hospital Essen, Germany.

Background And Purpose: The purpose of this study was to investigate the natural course of cerebral cavernous malformations (CCM) in the pediatric population, with special emphasis on the risk of first and recurrent bleeding over a 5-year period.

Methods: Our institutional database was screened for patients with CCM treated between 2003 and 2020. Patients ≤18 years of age with complete magnetic resonance imaging data set, clinical baseline characteristics, and ≥1 follow-up examination were included. Read More

View Article and Full-Text PDF

Natural History of Brainstem Cavernous Malformations: On the Variation in Hemorrhage Rates.

World Neurosurg 2022 01 14;157:e342-e350. Epub 2021 Oct 14.

Department of Neurosurgery, Kantonsspital St. Gallen, Rorschacher St. Gallen, Switzerland.

Background: Hemorrhage rates of conservatively managed brainstem cavernous malformations (BSCMs) vary widely in the literature. We aimed to elucidate the reason for the variation and to add the results of our experience of BSCMs management over the past decade.

Methods: We performed a review of consecutive patients with BSCMs referred to our department in the period 2006-2018. Read More

View Article and Full-Text PDF
January 2022

The benefit and outcome prediction of acute surgery for hemorrhagic brainstem cavernous malformation with impending respiratory failure.

J Clin Neurosci 2021 Nov 24;93:213-220. Epub 2021 Sep 24.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China; National Center for Neuological Disorders, Shanghai 200040, China; Neurosurgical Institute of Fudan University, Shanghai 200040, China; Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai 200040, China; Research Units of New Technologies of Micro-Endoscopy Combination in Skull Base Surgery (2018RU008), Chinese Academy of Medical Sciences (CAMS), Shanghai 200040, China.

Objectives: Impending respiratory failure is catastrophic neurological deterioration caused by repeated c of a brainstem cavernous malformation (BSCM). The benefit and outcome prediction of acute surgery for this fatal condition is rarely reported. In this study, the authors reported a case series of acute surgical treatment (≤3 weeks after the last hemorrhagic episode) for the BSCM with impending respiratory failure and reviewed literature over the past 20 years. Read More

View Article and Full-Text PDF
November 2021

A Rare Case of Cavernous Hemangioma of the Mitral Valve Presenting As Multifocal Embolic Brain Infarcts.

Cureus 2021 Sep 4;13(9):e17721. Epub 2021 Sep 4.

Internal Medicine, Chicago Medical School Internal Medicine Residency Program at Northwestern McHenry Hospital, McHenry, USA.

Primary cardiac tumors (PCTs) are rare and represent a heterogeneous group of tumors, potentially arising from various parts of the heart. The majority of these tumors are benign (90%), with myxoma being the most common subtype. Cardiac hemangiomas are rare vascular tumors that constitute 1-2% of all benign heart neoplasms. Read More

View Article and Full-Text PDF
September 2021

Impacting the Treatment of Highly Eloquent Supratentorial Cerebral Cavernous Malformations by Noninvasive Functional Mapping-An Observational Cohort Study.

Oper Neurosurg (Hagerstown) 2021 11;21(6):467-477

Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Germany.

Background: Cerebral cavernous malformations (CCM) may cause cavernoma-related epilepsy (CRE) and intracranial hemorrhage (ICH). Functional mapping has shown its usefulness during the resection of eloquent lesions including the treatment of brain arteriovenous malformations.

Objective: To evaluate the impact of noninvasive functional mapping on decision-making and resection of eloquently located CCM. Read More

View Article and Full-Text PDF
November 2021

An Unusual Presentation of Retrobulbar Cavernous Hemangioma in a Young Woman.

Cureus 2021 Aug 27;13(8):e17508. Epub 2021 Aug 27.

Cardiology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.

A 38-year-old woman presented with sudden-onset painful lid swelling, proptosis and external ophthalmoplegia on the right side for 20 days, associated with loss of vision for nine days. On contrast-enhanced computed tomography (CECT), a retrobulbar mass was noted involving intraconal and extraconal spaces, extending up to the orbital foramina with enhancement and thickening of meninges. CT arteriography further revealed multiple feeding vessels from the maxillary artery. Read More

View Article and Full-Text PDF

The trajectory of the medial longitudinal fasciculus in the human brain: A diffusion imaging-based tractography study.

Hum Brain Mapp 2021 12 1;42(18):6070-6086. Epub 2021 Oct 1.

Department of Neurosurgery, Capital Medical University Xuanwu Hospital, Beijing, China.

The aim of this study is to investigate the trajectory of medial longitudinal fasciculus (MLF) and explore its anatomical relationship with the oculomotor nerve using tractography technique. The MLF and oculomotor nerve were reconstructed at the same time with preset three region of interests (ROIs): one set at the area of rostral midbrain, one placed on the MLF area at the upper pons, and one placed at the cisternal part of the oculomotor nerve. This mapping protocol was tested in an HCP-1065 template, 35 health subjects from Massachusetts General Hospital (MGH), 20 healthy adults and 6 brainstem cavernous malformation (BCM) patients with generalized q-sampling imaging (GQI)-based tractography. Read More

View Article and Full-Text PDF
December 2021

Editorial for "Perfusion and Permeability Magnetic Resonance Imaging (MRI) Predicts Future Cavernous Angioma Hemorrhage and Growth".

David Hasan

J Magn Reson Imaging 2022 05 29;55(5):1450-1451. Epub 2021 Sep 29.

Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

View Article and Full-Text PDF

Fetal Familial Cerebral Cavernous Malformation With a Novel Heterozygous Variation.

Neurology 2021 11 23;97(21):986-988. Epub 2021 Sep 23.

From the Departments of Radiology (D.C., Y.L.), and Obstetrics (X.S., W.G.), Beijing Tiantan Hospital, Capital Medical University, China; UCL Institutes of Neurology and Healthcare Engineering (F.B.), London, United Kingdom; and Department of Radiology and Nuclear Medicine (F.B.), Amsterdam University Medical Centers, the Netherlands.

Background And Objectives: To identify fetal familial cerebral cavernous malformation (CCM) and a novel variation.

Methods: A 37-year-old pregnant woman (G4P0) presented with right-handed numbness since 2 weeks at 31 weeks of gestation. Evaluation with brain MRI revealed multiple CCMs. Read More

View Article and Full-Text PDF
November 2021

[Consistency analysis between 3D arterial spin labeling and dynamic susceptibility contrast perfusion magnetic resonance imaging in perfusion imaging of brain tumor].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Aug;41(8):1283-1286

Department of Radiology, Hainan Cancer Hospital, Haikou 570300, China.

Objective: To analyze the consistency between cerebral blood flow (CBF) of 3D arterial spin labeling (3D ASL) and dynamic susceptibility contrast perfusion magnetic resonance imaging (DSC-PWI) in the measurement of brain tumors.

Methods: Nineteen patients with pathologically confirmed brain tumors were enrolled in this study.The brain tumors included glioma (=9), meningioma (=5), hemangioblastoma (=2), cerebral metastasis (=2) and cavernous hemangioma (=1). Read More

View Article and Full-Text PDF

Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project.

Stroke 2021 12 16;52(12):3829-3838. Epub 2021 Sep 16.

Department of Neurosurgery (A. Stadnik, K.P., N.H., A. Shkoukani, J.C.-P., I.A.), University of Chicago, IL.

Background And Purpose: Brain cavernous angiomas with symptomatic hemorrhage (CASH) have a high risk of neurological disability from recurrent bleeding. Systematic assessment of baseline features and multisite validation of novel magnetic resonance imaging biomarkers are needed to optimize clinical trial design aimed at novel pharmacotherapies in CASH.

Methods: This prospective, multicenter, observational cohort study included adults with unresected, adjudicated brain CASH within the prior year. Read More

View Article and Full-Text PDF
December 2021

Microsurgical Treatment for Posthemorrhagic Cavernoma of Frontal Lobe Coexisting with Unruptured Ipsilateral Middle Cerebral Artery Aneurysm.

World Neurosurg 2021 12 8;156:27. Epub 2021 Sep 8.

Department of Neurosurgery, Universidade Federal de Sao Paulo, São Paulo-SP, Brazil; Hospital Beneficência Portuguesa de São Paulo, São Paulo-SP, Brazil. Electronic address:

Cerebral cavernous malformations, also known as cavernomas, are vascular abnormalities of the brain that are clinically associated with a variety of neurologic symptoms that may include hemorrhagic strokes. They are the most common vascular abnormality, representing 10%-25% of all vascular malformations. Lesions associated with cavernomas include developmental venous anomalies, capillary telangiectasias, and other vascular malformations but not intracranial aneurysms. Read More

View Article and Full-Text PDF
December 2021

Intraoperative brain mapping during awake surgery in symptomatic supratentorial cavernomas.

Neurocirugia (Astur : Engl Ed) 2021 Sep-Oct;32(5):217-223

Departmento de Psicobiología, Universidad de Valencia, Spain.

Background: Complete resection of symptomatic supratentorial cavernoma (SCA) and removal of the surrounding gliotic area is recommended to minimize the risk of persistent seizures or (re)bleeding. Surgery of SCA located in an eloquent area, can carry out severe postoperative neurological morbidity. We report a study aimed to assess feasibility, extent of resection and outcome after surgical removal of CA by cortico-subcortical intraoperative brain stimulation (ioBS) in the awake patient. Read More

View Article and Full-Text PDF
September 2021

Outcome of intracerebral cavernoma treated by Gamma Knife radiosurgery based on a double-blind assessment of treatment indication.

Radiat Oncol 2021 Aug 28;16(1):164. Epub 2021 Aug 28.

Department of Medical Research and Neurosurgery, Taichung Veterans General Hospital, 1650 Taiwan Boulevard Sec.4, Taichung, 40705, Taiwan.

Background: The benefit and the risk profile of Gamma Knife radiosurgery (GKRS) for intracerebral cavernoma remains incompletely defined in part due to the natural history of low incidence of bleeding and spontaneous regression of this vascular malformation. In this study, we retrieved cases from a prospectively collected database to assess the outcome of intracerebral cavernoma treated with GKRS using a double blinded review process for treatment.

Methods: From 2003 to 2018, there were 94 cases of cavernoma treated by GKRS in the doubly blinded assessments by two experienced neurological and approved for GKRS treatment. Read More

View Article and Full-Text PDF

Electroconvulsive Therapy in a Patient With Known Parietal Cerebral Cavernous Malformation.

J ECT 2021 09;37(3):e24

Department of ECT, Barnet, Enfield, and Haringey Mental Health Trust, Enfield, United Kingdom.

View Article and Full-Text PDF
September 2021

Microsurgical management of midbrain cavernous malformations: does lesion depth influence the outcome?

Acta Neurochir (Wien) 2021 10 20;163(10):2739-2754. Epub 2021 Aug 20.

Department of Neurosurgery, International Neuroscience Institute (INI), Rudolf Pichlmayr-Strasse 4, 30625, Hannover, Germany.

Background: The purpose of this study was to clarify whether the intrinsic depth of midbrain cavernous malformations (MCMs) influenced the surgical outcome.

Methods: The authors conducted a retrospective study of 76 consecutive patients who underwent microsurgical resection of a MCM. The vascular lesions were categorized into 4 distinct groups based on how these lesions had altered the brainstem surface. Read More

View Article and Full-Text PDF
October 2021