1,472 results match your criteria Brain Imaging in Cavernous Angiomas


Endoscopic Endonasal Surgery for the Resection of a Cavernous Hemangioma with a Sellar Extension.

Cureus 2018 Nov 30;10(11):e3663. Epub 2018 Nov 30.

Neurological Surgery, University of Louisville School of Medicine, Louisville, USA.

Cavernous hemangiomas with an intrasellar extension are very rare, generally benign lesions that manifest by the compression of nearby structures. The presenting symptoms usually range from visual disturbances to an endocrine imbalance. Occasional extension into the cavernous sinus has been reported, which can cause cranial nerve compression. Read More

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http://dx.doi.org/10.7759/cureus.3663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355302PMC
November 2018
1 Read

Clinical Features, Intradural Transcavernous Surgical Management, and Outcomes of Giant Cavernous Sinus Hemangiomas: A Single-Institution Experience.

World Neurosurg 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

Background: Cavernous sinus hemangiomas (CSHs) are rare vascular tumors. Stereotactic radiosurgery is an effective treatment for small CSHs. The optimal treatment for giant CSHs is controversial. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.165DOI Listing
February 2019
3 Reads
2.417 Impact Factor

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
14 Reads

Surgical treatment of an asymptomatic giant supratentorial cavernous hemangioma. Case report.

J Clin Neurosci 2019 Apr 4;62:231-234. Epub 2019 Jan 4.

LINT, Facultad de Medicina, Universidad Nacional de Tucumán, Tucumán, Argentina; Chief of Department of Neurological Surgery, Hospital Padilla, Tucumán, Argentina.

A case is reported of a 19-year old patient with a supratentorial giant cavernous malformation (GCM). This was an incidental finding in the context of acute head trauma. Brain computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed a giant supratentorial right mass. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183205
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http://dx.doi.org/10.1016/j.jocn.2018.12.032DOI Listing
April 2019
2 Reads

Vis-à-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis.

Neurol Sci 2019 Feb 6;40(2):243-251. Epub 2018 Dec 6.

Department of Biomedical and Dental Science and Morphological and Functional Images, University of Messina, Consolare Valeria street 1, 98125, Messina, Italy.

Cerebrovascular malformations include a wide range of blood vessel disorders affecting brain vasculature. Neuroimaging differential diagnosis can result unspecific due to similar phenotypes of lesions and their deep localization. Next-generation sequencing (NGS) platforms simultaneously analyze several hundreds of genes and can be applied for molecular distinction of different phenotypes within the same disorder's macro-area. Read More

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http://dx.doi.org/10.1007/s10072-018-3674-xDOI Listing
February 2019
2 Reads

Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.

Neurosurgery 2018 Nov 26. Epub 2018 Nov 26.

Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago Medicine and Biological Sciences, Chicago, Illinois.

Background: More than a million Americans harbor a cerebral cavernous angioma (CA), and those who suffer a prior symptomatic hemorrhage have an exceptionally high rebleeding risk. Preclinical studies show that atorvastatin blunts CA lesion development and hemorrhage through inhibiting RhoA kinase (ROCK), suggesting it may confer a therapeutic benefit.

Objective: To evaluate whether atorvastatin produces a difference compared to placebo in lesional iron deposition as assessed by quantitative susceptibility mapping (QSM) on magnetic resonance imaging in CAs that have demonstrated a symptomatic hemorrhage in the prior year. Read More

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http://dx.doi.org/10.1093/neuros/nyy539DOI Listing
November 2018
5 Reads

Hemichorea associated with cavernous angioma and a small errhysis: A case report and literature review.

Medicine (Baltimore) 2018 Oct;97(43):e12889

Departments of Neurosurgery.

Rationale: Chorea is a movement disorder characterized by randomly appearing involuntary movements of the face, neck, limbs, or trunk. Hemichorea is unilateral, involving one side of the body. Hemichorea is commonly caused by non-ketotic hyperglycemia and/or cerebrovascular injury to the contralateral basal ganglia. Read More

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http://dx.doi.org/10.1097/MD.0000000000012889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221695PMC
October 2018
1 Read

Pediatric Congenital Cerebrovascular Anomalies.

J Neuroimaging 2019 Mar 31;29(2):165-181. Epub 2018 Oct 31.

Department of Interventional Radiology, Sanford Aberdeen Clinic, Aberdeen, SD.

Congenital cerebrovascular anomalies in the pediatric age group are myriad with diverse etiologies. The purpose of this paper is to provide an imaging overview of congenital vascular malformations and vascular tumors, as these conditions are varied and the characteristic vascular abnormality may even suggest the underlying systemic condition in helping to guide further management. For example, the identification of an arterial anomaly such as agenesis/hypoplasia/duplication may warrant further evaluation for an associated syndrome. Read More

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http://doi.wiley.com/10.1111/jon.12575
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http://dx.doi.org/10.1111/jon.12575DOI Listing
March 2019
23 Reads

Whole-Brain Network Connectivity Underlying the Human Speech Articulation as Emerged Integrating Direct Electric Stimulation, Resting State fMRI and Tractography.

Front Hum Neurosci 2018 11;12:405. Epub 2018 Oct 11.

Division of Neurosurgery, "S. Chiara" Hospital, Azienda Provinciale per i Servizi Sanitari, Trento, Italy.

Production of fluent speech in humans is based on a precise and coordinated articulation of sounds. A speech articulation network (SAN) has been observed in multiple brain studies typically using either neuroimaging or direct electrical stimulation (DES), thus giving limited knowledge about the whole brain structural and functional organization of this network. In this study, seven right-handed patients underwent awake surgery resection of low-grade gliomas (4) and cavernous angiomas. Read More

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https://www.frontiersin.org/article/10.3389/fnhum.2018.00405
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http://dx.doi.org/10.3389/fnhum.2018.00405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193478PMC
October 2018
10 Reads

Adrenal medullary hyperplasia with coexistent cerebral angiomas.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):587-589

Department of Surgery, Maulana Azad Medical College, New Delhi, India.

Sporadic adrenal medullary hyperplasia (AMH) is a rare entity and mimics pheochromocytoma clinically as well as pharmacologically. It is characterized by increase in adrenal medullary cells with the expansion of cells into areas normally not seen. A 59-year-old male presented with chronic hypertension and raised 24-h urinary normetanephrine levels. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_707_17DOI Listing
February 2019
2 Reads

Giant Extra-Axial Cavernous Angioma of the Falx: Case Report.

Neurosurgery 2019 Mar;84(3):E211-E214

Department of Neurosurgery, Cantonal Hospital of Fribourg, Fribourg, Switzerland.

Background And Importance: Cavernous angiomas or cavernomas are vascular malformations usually located in the brain parenchyma. However, they rarely present as extra-axial lesions, attached to the dura, and may mimic meningiomas. Most reported cases concern the cavernous sinus region and other locations are very uncommon. Read More

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https://academic.oup.com/neurosurgery/advance-article/doi/10
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http://dx.doi.org/10.1093/neuros/nyy080DOI Listing
March 2019
16 Reads

Multiple Cavernous Malformations of Brain, Chest, and Skin: A Rare Case of an Infant and Literature Review.

World Neurosurg 2018 Dec 29;120:177-180. Epub 2018 Aug 29.

Department of Neurosurgery, Guangzhou Women and Children's Medical Center, Guangzhou, China. Electronic address:

Background: Cerebral cavernous malformations (CCMs) are vascular malformations that account for 5%-15% of all central nervous system vascular malformations. However, multiple CCMs, which can be sporadic or familial, are rare, with a prevalence of 0.1%-0. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.152DOI Listing
December 2018
5 Reads

The Real Impact of an Intraoperative Magnetic Resonance Imaging-Equipped Operative Theatre in Neurovascular Surgery: The Sapienza University Experience.

World Neurosurg 2018 Dec 27;120:190-199. Epub 2018 Aug 27.

A.O.U. "Sant'Andrea", Neurosurgery Division, NESMOS Department, Sapienza University, Rome, Italy. Electronic address:

The fundamental role of technological instruments in contemporary Neurosurgery is undisputed, and intraoperative magnetic resonance imaging (MRI) represents one of the best examples. The use of a modern high-field magnet and the possibility to match the MRI with an operative microscope and an integrated neuronavigation system has led to successful results in the surgical treatment of different diseases. At our institute, we have performed surgery routinely with the aid of intraoperative MRI over the last 15 years. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.124DOI Listing
December 2018
1 Read

Cerebral Venous Malformations in a Chinese Population: Clinical Manifestations, Radiological Characteristics, and Long-Term Prognosis.

World Neurosurg 2018 Dec 25;120:e472-e479. Epub 2018 Aug 25.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.

Objective: We elucidated the clinical and radiological characteristics and analyzed the risk factors for hemorrhage and poor outcomes of cerebral venous malformations (CVMs) in a northern Chinese population.

Methods: We included 60 consecutive patients with CVM patients in Beijing Tiantan Hospital from January 2011 to February 2018. The clinical manifestations, radiological characteristics, management, and outcomes were elucidated and analyzed. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.08.106DOI Listing
December 2018
10 Reads

[Surgical treatment of epilepsy in patients with mediobasal temporal cavernous malformations].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(4):45-56

Treatment and rehabilitation center, Moscow, Russia.

Objective: Epilepsy is a frequent clinical manifestation of cavernous malformations (CMs) of the mediobasal temporal region (MBTR). Surgical removal of CMs is an excellent technique for treating associated epilepsy and may range from pure lesionectomy to tailored resection of the temporal lobe.

Purpose: The study purpose was to determine the optimal surgical management for epilepsy in patients with CMs of the MBTR. Read More

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http://dx.doi.org/10.17116/neiro201882445DOI Listing
February 2019
42 Reads

Stereotactic radiosurgery for hypervascular intracranial tumors.

J Neurooncol 2018 Dec 20;140(3):547-558. Epub 2018 Aug 20.

Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, 17F, No. 201, Shih-Pai Road, Sec. 2, Beitou, Taipei, 11217, Taiwan, ROC.

Objective: To evaluate the safety and efficacy of SRS treatment of central neurocytomas (CNCs), cavernous sinus hemangiomas (CSHs), and glomus tumors (GTs); and to compare upfront stereotactic radiosurgery (SRS) and adjuvant SRS in the treatment of these hypervascular tumors.

Methods: This was a retrospective review of consecutive CNCs, CSHs, and GTs treated with SRS between 1993 and 2017. Tumor response was categorized based on volumetric analysis on magnetic resonance imaging: (1) tumor regression [> 10% decrease in tumor volume (TV)]; (2) stable tumor (≤ 10% change in TV); or (3) tumor progression (> 10% increase in TV). Read More

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http://dx.doi.org/10.1007/s11060-018-2980-8DOI Listing
December 2018
3 Reads

Ophthalmic Artery Occlusion Following Facial Sclerosing Therapy.

J Ophthalmic Vis Res 2018 Jul-Sep;13(3):351-354

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To describe a case of ophthalmic artery occlusion and complete ophthalmoplegia after intralesional injection of a sclerosing agent into a subcutaneous hemangioma on the forehead.

Case Report: A 16-year-old girl underwent direct injection of 3 mL of sodium tetradecyl sulfate (Fibrovein) emulsion 1% (10 mg/mL) with a 23-gauge needle into a subcutaneous hemangioma on the forehead. Immediately after the injection, she developed sudden loss of vision and lid swelling of the left eye. Read More

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http://dx.doi.org/10.4103/jovr.jovr_29_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058543PMC
August 2018
4 Reads

Surgical Management and Functional Outcomes of Cavernous Malformations Involving the Medulla Oblongata.

World Neurosurg 2018 Nov 2;119:e643-e652. Epub 2018 Aug 2.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China; China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China. Electronic address:

Objective: The aim of this study was to evaluate the clinical features, surgical complications, and functional outcomes of the surgical treatment of patients with cavernous malformations (CMs) involving the medulla oblongata.

Methods: The charts of 69 patients undergoing surgical treatment of CMs in the medulla oblongata, pontomedullary, and cervicomedullary junctions between 2011 and 2017 were retrospectively reviewed. Patient demographics, lesion characteristics, operative documents, and patient outcomes were examined. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.229DOI Listing
November 2018
5 Reads

Evaluation of sporadic intracranial cavernous malformations for detecting associated developmental venous anomalies: added diagnostic value of C-arm contrast-enhanced cone-beam CT to routine contrast-enhanced MRI.

Eur Radiol 2019 Feb 31;29(2):783-791. Epub 2018 Jul 31.

Department of Radiology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.

Objective: Our purpose was to investigate the added diagnostic value of C-arm contrast-enhanced cone-beam CT (CE-CBCT) to routine contrast-enhanced MRI (CE-MRI) in detecting associated developmental venous anomalies (DVAs) in patients with sporadic intracranial cavernous malformations (ICMs).

Methods: Fifty-six patients (53 with single and three with double ICMs) met the inclusion criteria. All patients had routine CE-MRI scans performed at 1. Read More

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http://link.springer.com/10.1007/s00330-018-5652-3
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http://dx.doi.org/10.1007/s00330-018-5652-3DOI Listing
February 2019
10 Reads

A case of reversible cerebral vasoconstriction syndrome and cavernous hemangioma: just a coincidence?

Neurol Sci 2018 Nov 30;39(11):1989-1990. Epub 2018 Jul 30.

Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.

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http://dx.doi.org/10.1007/s10072-018-3503-2DOI Listing
November 2018

Novel KRIT1/CCM1 heterozygous nonsense mutation (c.715 C>T) associated with cerebral and cerebellar cavernous malformations in a paediatric patient.

BMJ Case Rep 2018 Jul 30;2018. Epub 2018 Jul 30.

Department of Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA.

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http://dx.doi.org/10.1136/bcr-2018-226246DOI Listing
July 2018
1 Read

Surgical Management and Risk Factors of Postoperative Respiratory Dysfunction of Cavernous Malformations Involving the Medulla Oblongata.

World Neurosurg 2018 Oct 20;118:e956-e963. Epub 2018 Jul 20.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China; China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China. Electronic address:

Objective: To evaluate surgical management of cavernous malformations (CMs) involving the medulla oblongata and to predict risk factors of postoperative respiratory dysfunction (RDF).

Methods: Patient data from individuals who underwent surgical treatment for CMs involving the medulla oblongata were retrospectively reviewed. Patients with postoperative RDF and/or deficits of the cough reflex (CR, ≥7 days) were deemed as having bad respiratory statuses. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.109DOI Listing
October 2018
5 Reads

Intraoperative Computed Tomography and Awake Craniotomy: A Useful and Safe Combination in Brain Surgery.

World Neurosurg 2018 Nov 18;119:e159-e166. Epub 2018 Jul 18.

Department of Neurological Surgery, Policlinico "G. Rodolico" University Hospital, Catania, Italy; Interdisciplinary Research Center on Brain Tumor Diagnosis and Treatment, University of Catania, Catania, Italy.

Background: Awake surgery is an effective technique to improve safety in surgical resection of lesions involving eloquent areas of the brain. Intraoperative imaging guidance and neuronavigation are widely applied in neurosurgical procedures. However, data on the application of intraoperative imaging to awake craniotomies are limited. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.078DOI Listing
November 2018
1 Read

Endoscopic Transnasal Transclival Approach to a Pontine Cavernoma with Associated Developmental Venous Anomaly.

World Neurosurg 2018 Oct 18;118:212-218. Epub 2018 Jul 18.

Department of Neurological Surgery, George Washington University, Washington, DC, USA.

Background: Brainstem cavernous malformations represent around 8%-22% of all intracranial cavernous malformations but exhibit a higher annual incidence of hemorrhage (2%-3%) compared with other cavernous angiomas and tend to be more symptomatic given their proximity to critical nuclei and fiber tracts. Recently, endoscopic endonasal techniques have been used for the removal of ventral skull base lesions, with significant improvement in operative morbidity and mortality compared with open approaches. Here we demonstrate the utility and feasibility of the endoscopic transclival approach for ventrally located pontine cavernomas in carefully selected patients. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.084DOI Listing
October 2018
13 Reads

Detection of cavernous malformations after whole-brain radiotherapy in primitive neuroectodermal tumor patients-comparing susceptibility-weighted imaging and T2 gradient-echo sequences.

Neuroradiology 2018 Sep 20;60(9):913-919. Epub 2018 Jul 20.

Department of Diagnostic Imaging, Sheba Medical Center, Derech Sheba 2, Ramat Gan, Israel.

Purpose: The aim of this retrospective study is to investigate the value of the susceptibility-weighted imaging (SWI) sequence compared to gradient echo (GRE) in the detection and follow-up of cavernous malformations in patients who underwent whole-brain irradiation as part of their medulloblastoma treatment.

Methods: We retrospectively examined MRI studies of 28 subjects (16 males, 12 females) who received whole-brain irradiation as part of their treatment. Ages at irradiation ranged from 2 to 38 years. Read More

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http://dx.doi.org/10.1007/s00234-018-2055-8DOI Listing
September 2018
3 Reads

Surgical Treatment of the Medullary Cavernous Malformations: 53 Cases.

World Neurosurg 2018 Oct 4;118:e449-e459. Epub 2018 Jul 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Dongcheng District, Beijing, People's Republic of China; China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China. Electronic address:

Objective: The aim of this study was to investigate patient clinical features, surgical complications and outcomes, and the prognostic risk factors of surgical treatment of cavernous malformations (CMs) involving the medulla oblongata.

Methods: The charts of 53 patients who underwent surgical treatment for CMs involving the medulla oblongata between 2011 and 2017 were reviewed retrospectively. Patient demographics, lesion characteristics, operative documents, and patient outcomes were examined. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.213DOI Listing
October 2018
16 Reads

Transcallosal Anterior Interforniceal Approach for Removal of Superior Midbrain Cavernous Malformations in Children: A Retrospective Series of 10 Cases in a Single Center.

World Neurosurg 2018 Oct 30;118:e188-e194. Epub 2018 Jun 30.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:

Background: Surgical treatment of brainstem cavernous malformations (CMs) remains a great challenge for neurosurgeons. Several cases published in the literature have addressed surgical approaches. However, no surgical approach has been reported to provide better exposure for CMs located in the superior midbrain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183136
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http://dx.doi.org/10.1016/j.wneu.2018.06.152DOI Listing
October 2018
12 Reads

Craniotomy for a Large and Aggressive De Novo Cavernous Malformation Resection in the Basal Ganglia Region.

World Neurosurg 2018 Sep 18;117:298-300. Epub 2018 Jun 18.

Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address:

Background: Cerebral cavernous malformations (CCMs) are present in up to 0.5% of the general population. Although CCMs have been considered congenital lesions, numerous reports have observed de novo formations in patients with the familial form of CCM and in patients after cranial radiotherapy. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.067DOI Listing
September 2018
20 Reads

Long-Term Outcome of Gamma Knife Radiosurgery for Symptomatic Brainstem Cavernous Malformation.

World Neurosurg 2018 Aug 2;116:e1054-e1059. Epub 2018 Jun 2.

Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.

Objective: We sought to analyze the long-term outcome of Gamma Knife radiosurgery (GKS) for symptomatic brainstem cavernous malformation (s-BSCM).

Methods: Forty-five patients (14 males, 31 females) were treated with GKS for s-BSCM from January 1998 to December 2011. All patients were followed up for >5 years, and their clinical data were analyzed retrospectively. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.05.164DOI Listing
August 2018
4 Reads

Usefulness of Ultrasound-Guided Microsurgery in Cavernous Angioma Removal.

World Neurosurg 2018 Aug 9;116:e414-e420. Epub 2018 May 9.

Department of Neurosurgery and Gamma Knife Radiosurgery, Vita-Salute University, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Background: Primary elements of surgical treatment of cavernous angiomas (CAs) are precise lesion identification and optimal trajectory determination. Navigation techniques allow for better results compared to microsurgery alone. In this study, we examined the benefits of intraoperative ultrasound (IOUS) use as an adjunct to standard localization systems. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.04.217DOI Listing
August 2018
6 Reads

Widespread and debilitating hemangiomas in a patient with enchondromatosis and D-2-hydroxyglutaric aciduria.

Skeletal Radiol 2018 Nov 10;47(11):1577-1582. Epub 2018 May 10.

Center of Excellence for Medical Genetics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.

Metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA) (OMIM 614875) is a severe chondrodysplasia combined with a urinary excretion of D-2-hydroxyglutaric acid. Here, we reported the tenth case of this disease. A 15-year-old boy had symmetric radiolulencies in the metaphyses of the long bones suggesting enchondromatosis and platyspondyly. Read More

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http://link.springer.com/10.1007/s00256-018-2963-z
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http://dx.doi.org/10.1007/s00256-018-2963-zDOI Listing
November 2018
22 Reads

Hemangioma of the Cavernous Sinus: A Case Series.

J Neurol Surg Rep 2018 Apr 26;79(2):e26-e30. Epub 2018 Apr 26.

Departments of Neurological Surgery, University of California, Davis Medical Center, Sacramento, California, United States.

 Cavernous sinus hemangiomas (CSHs) are rare, vascular, extra-axial tumors that are diagnosed with a combination of imaging and biopsy. We describe the clinical presentations, imaging findings, and management of two male patients with CSHs.  Case 1 describes a 57-year-old man who presented with vision changes and cranial nerve palsies. Read More

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http://dx.doi.org/10.1055/s-0038-1641731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919774PMC
April 2018
5 Reads

Lacunar Stroke, Cavernous Angioma, and Fusiform Aneurysm Due to Irradiation for Pilocytic Astrocytoma-A Case Report.

J Stroke Cerebrovasc Dis 2018 Aug 16;27(8):e165-e167. Epub 2018 Apr 16.

Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.

Radiotherapy is a useful modality for the treatment of brain tumors, but may induce brain degeneration, tumor formation, and vasculopathy in the irradiated field. We describe a rare case of a pediatric patient who presented multiple different types of vascular events consecutively in the irradiated field including lacunar stroke because of occlusion of perforating artery, intraventricular hemorrhage from cavernoma, and subarachnoid hemorrhage because of the rupture of fusiform aneurysm, 6 years after radiotherapy against pilocytic astrocytoma. The life-threatening aneurysm was resected, and its histologic findings revealed the radiation-induced vasculopathy. Read More

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2018.02.062DOI Listing
August 2018
10 Reads

Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH).

Neurosurgery 2019 Apr;84(4):954-964

Neurovascular Surgery Program, Section of Neurosurgery, Department of Surgery, University of Chicago Medicine and Biological Sciences, Chicago, Illinois.

Background: Brain cavernous angiomas with symptomatic hemorrhage (CASH) are uncommon but exact a heavy burden of neurological disability from recurrent bleeding, for which there is no proven therapy. Candidate drugs to stabilize the CASH lesion and prevent rebleeding will ultimately require testing of safety and efficacy in multisite clinical trials. Much progress has been made in understanding the epidemiology of CASH, and novel biomarkers have been linked to the biological mechanisms and clinical activity in lesions. Read More

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http://dx.doi.org/10.1093/neuros/nyy108DOI Listing
April 2019
11 Reads

Multiple Intracranial Cavernous Angiomas With a Trigonal Cavernous Angioma Mimicking Glioma.

J Craniofac Surg 2018 Oct;29(7):e635-e637

Department of Neurosurgery, Jiaozhou Central Hospital, Qingdao, China.

Intracranial cavernous angiomas (CAs) are hamartomatous vascular malformations consisting of thin-walled vascular channels located within the brain, but typically lacking intervening neural parenchyma, large feeding arteries, or draining veins. The CAs occurring in the ventricular system are rare, with an incidence of 2.5% to 10. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004544DOI Listing
October 2018
6 Reads

Clinical characteristics and surgical outcomes of solitary spinal epidural cavernous angiomas.

Oncol Lett 2018 Apr 12;15(4):6036-6042. Epub 2018 Feb 12.

Department of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China.

The majority of spinal cavernous angiomas (CAs) originate from the vertebral bodies with or without epidural space extension. Solitary epidural CAs are rare. In the present study, we retrospectively reviewed the records of 12 patients who underwent microsurgery for solitary spinal epidural CAs. Read More

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http://dx.doi.org/10.3892/ol.2018.8024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840503PMC
April 2018
1 Read

Staged Management of Intracranial Masson Tumor: An Unexpected Gauntlet: Case Report and Review of the Literature.

World Neurosurg 2018 Jun 14;114:194-203. Epub 2018 Mar 14.

Department of Neurosurgery, Hospital Universitario Virgen del Rocío, Seville, Spain.

Background: Intravascular papillary endothelial hyperplasia (IPEH), also known as Masson tumor, is a benign lesion consisting of a reactive proliferation of endothelial cells with papillary formations related to thrombi. It has been reported in many different anatomic areas. Gross total resection is the elected treatment. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.03.054DOI Listing
June 2018
3 Reads

Transient Focal Magnetic Resonance Imaging Abnormalities After Status Epilepticus Showed 11C-Methionine Uptake with Positron Emission Tomography in a Patient with Cerebral Cavernous Malformation.

World Neurosurg 2018 Jun 10;114:43-46. Epub 2018 Mar 10.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.

Background: Transient focal magnetic resonance imaging (MRI) abnormalities after status epilepticus (SE) are rarely seen in patients with benign brain tumors, and the underlying mechanism is still unknown. We report a rare case of cerebral cavernous malformation with transient focal MRI abnormalities around the tumor and accumulation of 11C-methionine on positron emission tomography (PET) after SE. These findings mimicked those of a glioma because the MRI and methionine PET findings were similar. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.03.020DOI Listing
June 2018
12 Reads

Extended middle fossa approach to lateralized pontine cavernomas in children.

J Neurosurg Pediatr 2018 04 2;21(4):384-388. Epub 2018 Feb 2.

1Department of Pediatric Neurosurgery, University of California, San Diego, California.

OBJECTIVE Treatment of hemorrhagic cavernous malformations within the lateral pontine region demands meticulous surgical planning and execution to maximize resection while minimizing morbidity. The authors report a single institution's experience using the extended middle fossa rhomboid approach for the safe resection of hemorrhagic cavernomas involving the lateral pons. METHODS A retrospective chart review was performed to identify and review the surgical outcomes of patients who underwent an extended middle fossa rhomboid approach for the resection of hemorrhagic cavernomas involving the lateral pons during a 10-year period at Rady Children's Hospital of San Diego. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/21/4/ar
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http://dx.doi.org/10.3171/2017.10.PEDS17381DOI Listing
April 2018
15 Reads

Hypertrophic Olivary Degeneration: Neurosurgical Perspective and Literature Review.

World Neurosurg 2018 Apr 31;112:e763-e771. Epub 2018 Jan 31.

Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA. Electronic address:

Background: Hypertrophic olivary degeneration (HOD) occurs because of posterior fossa or brainstem lesions that disrupt the dentato-rubro-olivary tract, well known as the Guillain-Mollaret triangle. Clinical and radiologic hallmarks of this condition are palatal myoclonus and T2 hyperintensity of the inferior olivary complex on magnetic resonance imaging (MRI), respectively. Because symptomatic HOD can complicate the recovery of patients with posterior fossa or brainstem lesions, the purpose of this study is to evaluate clinical and imaging findings of patients with HOD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183019
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http://dx.doi.org/10.1016/j.wneu.2018.01.150DOI Listing
April 2018
11 Reads
2.420 Impact Factor

Hemorrhagic Brain Metastases in a Patient with Anaplastic Lymphoma Kinase (ALK)-Rearranged Invasive Mucinous Adenocarcinoma of the Lung.

Am J Case Rep 2018 Jan 26;19:99-104. Epub 2018 Jan 26.

Department of Pathology and Translational Pathobiology, Louisiana State University Health Science Center, Shreveport, LA, USA.

BACKGROUND Invasive mucinous adenocarcinoma (IMA) is a rare variant of adenocarcinoma of the lung. It frequently shows KRAS mutations, while ALK rearrangement is exceedingly rare. We present a case of ALK-rearranged IMA of the lung presenting with an unusual pattern of brain metastases, radiologically mimicking a cavernous angioma. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796364PMC
January 2018
14 Reads

Clinical features and neurosurgical treatment of trigonal cavernous malformations.

Neurosurg Rev 2018 Jul 26;41(3):877-890. Epub 2017 Dec 26.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, NO.6 Tiantan Xili, Dongcheng District, Beijing, 100050, People's Republic of China.

The goals of this study were to analyze the incidence, clinical manifestations, neuroimaging findings, surgical treatments, and neurological outcomes of trigonal cavernous malformations (TCMs). Among 1395 cases of intracranial and intraspinal cavernous malformations (CMs) surgically treated between 2003 and 2016 at Beijing Tiantan Hospital, a series of 12 patients with TCM was chosen for analysis and their records were reviewed. We also performed an exhaustive literature search using PubMed to identify all previously reported cases in the literatures. Read More

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http://dx.doi.org/10.1007/s10143-017-0938-5DOI Listing
July 2018
6 Reads

Endoscopic management of Atypical sellar cavernous hemangioma: A case report and review of the literature.

Int J Surg Case Rep 2018 8;42:161-164. Epub 2017 Dec 8.

Neurosurgery Department, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Saudi Arabia. Electronic address:

Introduction: supratentorial cavernous hemangiomas, particularly those found in the sellar region, are extremely rare. We present a case of sellar cavernous hemangioma with radiological characteristics that have never been reported. Due to the difficulty diagnosing these lesions, misdiagnosis might occur. Read More

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http://dx.doi.org/10.1016/j.ijscr.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985255PMC
December 2017
9 Reads

Multiple sporadic cerebral cavernous malformations.

Arq Neuropsiquiatr 2017 Dec;75(12):895

Universidade Federal de Juiz de Fora, Faculdade de Medicina, Hospital Universitário, Unidade de Distúrbios do Movimento, Serviço de Neurologia, Juiz de Fora MG, Brasil.

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http://dx.doi.org/10.1590/0004-282X20170154DOI Listing
December 2017
2 Reads

Neurosurgical management of cavernous malformations located at the foramen of Monro.

Neurosurg Rev 2018 Jul 4;41(3):799-811. Epub 2017 Dec 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, People's Republic of China.

Cavernous malformations (CMs) located at the foramen of Monro (FM) are relatively rare benign vascular malformations. Knowledge of FM CM is poor. The aims of this study were to describe the incidence, clinical presentation, radiological features, surgical approaches, and neurological outcomes for FM CM patients and to discuss the treatment strategy for this disease. Read More

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http://dx.doi.org/10.1007/s10143-017-0930-0DOI Listing
July 2018
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Intrasellar cavernous hemangioma presenting as pituitary adenoma: A report of two cases and review of the literature.

Clin Neuropathol 2018 Mar/Apr;37(2):64-67

Cavernous hemangioma in the sellar region is quite rare with only a handful of cases being reported in the English literature. Its clinical manifestations and imaging characteristics can mimic those of a pituitary adenoma. We report two cases of recurrent sellar lesions, both of which were clinically suspected of being pituitary adenomas but histologically confirmed as cavernous hemangiomas. Read More

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http://dx.doi.org/10.5414/NP301012DOI Listing
August 2018
11 Reads

Surgical Management and Long-Term Seizure Outcome After Surgery for Temporal Lobe Epilepsy Associated with Cerebral Cavernous Malformations.

World Neurosurg 2018 Feb 22;110:e659-e670. Epub 2017 Nov 22.

Department of Epileptology, Fuzhou General Hospital, Fujian Medical University, Fuzhou, China.

Objective: Operative strategies for cerebral cavernous malformation (CCM)-associated temporal lobe epilepsy and timing of surgical intervention continue to be debated. This study aimed to establish an algorithm to evaluate the efficacy of surgical intervention strategies, to maximize positive surgical outcomes and minimize postsurgical neurologic deficits.

Methods: 47 patients having undergone operation for CCM-associated temporal lobe epilepsy were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.11.067DOI Listing
February 2018
12 Reads

A novel CCM1/KRIT1 heterozygous deletion mutation (c.1919delT) in a Chinese family with familial cerebral cavernous malformation.

Clin Neurol Neurosurg 2018 01 21;164:44-46. Epub 2017 Nov 21.

Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantan Xili, Dongcheng District, Beijing, 100050, China. Electronic address:

Background: Cerebral cavernous malformation (CCM) is a relatively rare congenital vascular anomaly in the central venous system. Its inherited form, familial cerebral cavernous malformation (FCCM), is an autosomal-dominant disease with incomplete penetrance. The pathogenic genes of FCCM have been mapped into three loci: CCM1/KRIT1, CCM2/MGC4607, and CCM3/PDCD10. Read More

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http://dx.doi.org/10.1016/j.clineuro.2017.11.005DOI Listing
January 2018
1 Read

Significant Hemorrhage Rate Reduction after Gamma Knife Radiosurgery in Symptomatic Cavernous Malformations: Long-Term Outcome in 95 Case Series and Literature Review.

Stereotact Funct Neurosurg 2017 4;95(6):369-378. Epub 2017 Nov 4.

Department of Neurological Surgery, Getafe University Hospital, Getafe, Spain.

Background: The natural history of cavernous malformations (CMs) has remained unclear. This lack of knowledge has made treatment decisions difficult. Indeed, the use of stereotactic radiosurgery is nowadays controversial. Read More

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http://dx.doi.org/10.1159/000480664DOI Listing
December 2018
13 Reads