1,619 results match your criteria Brain Imaging in Cavernous Angiomas

Hemorrhage of a Cavernous Hemangioma of the Brainstem Presenting with Fever of Unknown Origin: A Case Report.

Am J Case Rep 2021 May 25;22:e930437. Epub 2021 May 25.

Department of Neurosurgery, University Hospital of Patras, Patras, Greece.

BACKGROUND Cavernous malformations (CMs) or hemangiomas are benign vascular hamartomas of the central nervous system (CNS) that constitute 5-15% of all CNS vascular malformations. Most patients with brainstem CMs present with a sudden onset of seizures, intracranial hemorrhage, cranial nerve deficits, headache, or ataxia. Up to 20% to 50% of patients are asymptomatic, and their CMs are diagnosed incidentally on brain magnetic resonance imaging. Read More

View Article and Full-Text PDF

Resection of Pontine Cavernoma Through the Anterior Transpetrosal Approach: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Jun;21(1):E26-E27

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

The pons is the most frequent local for brain stem cavernoma.1 Repeated hemorrhage of brainstem cavernoma is associated with significant and accumulative neurological deficits and thus requires treatment. According to the Swedish Karolinska's group of radiosurgery, "it could not be concluded whether GKRS affects the natural course of a CM. Read More

View Article and Full-Text PDF

A case of cavernous hemangioma of the infratemporal fossa causing recurrent secretory otitis media.

Braz J Otorhinolaryngol 2021 Mar 26. Epub 2021 Mar 26.

Sant'Andrea Hospital, NESMOS Department, Medicine and Psychology, ENT Clinic, Rome, Italy; Sant'Andrea University Hospital, NESMOS Department, Otolaryngology Clinic, Rome, Italy. Electronic address:

Secretory otitis media causes aural fullness and hearing loss secondary to Eustachian tube obstruction or incomplete resolution of acute otitis media. Every patient with unilateral middle ear effusion should undergo nasopharyngoscopy to assess the nasopharyngeal space. Expansive lesions at the level of pterygopalatine fossa may cause Eustachian tube compression with tube dysfunction with clinical findings of recurrent unilateral secretory otitis media. Read More

View Article and Full-Text PDF

Acute presentation of third ventricular cavernous malformation following COVID-19 infection in a pregnant woman: A case report.

Neurochirurgie 2021 Mar 23. Epub 2021 Mar 23.

Department of neurosurgery, Imam Khomeini hospital, Tehran University of medical sciences, Keshavarz boulevard, Tehran, Iran.

Background: Cerebral cavernous malformation (CCM) in third ventricular area may become symptomatic relatively rarely, secondary to hemorrhage and growth or rupture into the ventricle, causing obstructive hydrocephalus, during third trimester of pregnancy.

Case Description: A 34 weeks pregnant (G4P1A2) lady was admitted to one of our satellite hospitals with one-week history of severe headache, blurred vision, nausea, vomiting, and right-sided facial numbness. At presentation, she had sudden decreased level of consciousness with Glasgow Coma Scale (GCS) equal to 4, and bilateral fixed pupils. Read More

View Article and Full-Text PDF

KRIT1 Gene in Patients with Cerebral Cavernous Malformations: Clinical Features and Molecular Characterization of Novel Variants.

J Mol Neurosci 2021 Mar 2. Epub 2021 Mar 2.

Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.

Cerebral cavernous malformations (CCMs) are vascular malformations that may result in headaches, seizures, focal neurological deficits, and hemorrhage. CCMs occur sporadically (80%) or in familial form (20%), with autosomal dominant inheritance. Among the three CCM-related genes, mutations in KRIT1 account for 53-65% of familial cases and more than 100 different mutations have been identified so far. Read More

View Article and Full-Text PDF

Spontaneous regression of multiple intracranial capillary hemangiomas in a newborn-long-term follow-up and literature review.

Childs Nerv Syst 2021 Jan 22. Epub 2021 Jan 22.

Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Intracranial capillary hemangiomas (ICHs) have a natural history and behavior that is very different from intracranial cavernous malformations. The literature is not consistent as to the best management strategy for ICHs.

Case Description: Our patient is a 40-day-old male infant who presented with progressive increase in head circumference and multiple cutaneous capillary and ICHs. Read More

View Article and Full-Text PDF
January 2021

A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).

Neurosurgery 2021 02;88(3):686-697

Neurovascular Surgery Program, Department of Surgery, Section of Neurosurgery, University of Chicago Medicine and Biological Sciences, Chicago, Illinois.

Background: Cerebral cavernous angioma (CA) is a capillary microangiopathy predisposing more than a million Americans to premature risk of brain hemorrhage. CA with recent symptomatic hemorrhage (SH), most likely to re-bleed with serious clinical sequelae, is the primary focus of therapeutic development. Signaling aberrations in CA include proliferative dysangiogenesis, blood-brain barrier hyperpermeability, inflammatory/immune processes, and anticoagulant vascular domain. Read More

View Article and Full-Text PDF
February 2021

Aeromedical Implications of Cerebral Cavernomas.

Aerosp Med Hum Perform 2021 Feb;92(2):120-123

Cavernomas, cavernous angiomas, or cerebral cavernous malformations are clusters of endothelium-lined blood vessels usually found in the brain. With the increasing use of radiological imaging, these are being detected incidentally in asymptomatic aircrew. The UK Civil Aviation Authority (CAA) experience of cavernomas is described and the aeromedical concerns, that is, the risk of epilepsy, hemorrhage, and the development of a neurological deficit, are considered. Read More

View Article and Full-Text PDF
February 2021

Opto-chiasmatic apoplexy as a compartment syndrome? Anatomical and surgical considerations on two bleeding cavernous malformations.

Clin Neurol Neurosurg 2021 02 15;201:106439. Epub 2020 Dec 15.

Department of Neurosciences - University of Padova, Padua, Italy.

Objective: Opto-chiasmatic (OC) cavernous malformations are sporadic lesions that are often misdiagnosed clinically and radiologically. Presenting symptoms range from incidental findings to the more frequent and dramatic "chiasmal apoplexy." The present study aims to evaluate the potential role of arachnoidal membranes of the basal cisterns in the onset of OC apoplexy. Read More

View Article and Full-Text PDF
February 2021

Extra-axial cerebellopontine angle cavernoma: A case report and review of literature.

Surg Neurol Int 2020 11;11:386. Epub 2020 Nov 11.

Department of Radiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Extra-axial cavernomas at the cerebellopontine angle (CPA) are rare clinical entity that can radiologically mimic several lesions encountered at this location.

Case Description: A 36-year-old female patient referred to our emergency service with acute decreased level of consciousness and vomiting. Neurological examination showed Glasgow Coma Scale of 12 with downbeat nystagmus of the right eye. Read More

View Article and Full-Text PDF
November 2020

Cavernous malformation of the intracranial optic nerve with operative video and review of the literature.

BMJ Case Rep 2020 Dec 17;13(12). Epub 2020 Dec 17.

Department of Neurological Surgery, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

Optic pathway cavernous malformations represent less than 1% of all central nervous system cavernomas. They can lead to visual loss with indeterminate speed, and therefore, the timing of intervention is controversial. We present a patient with an optic nerve cavernoma, which was discovered incidentally 3 years before the onset of visual symptoms. Read More

View Article and Full-Text PDF
December 2020

Awake intraoperative mapping to identify cortical regions related to music performance: Technical note.

J Clin Neurosci 2021 Jan 13;83:64-67. Epub 2020 Dec 13.

Department of Neurosurgery, Medical University of Warsaw, Poland.

The aim of this manuscript is to present our intraoperative technique assessing the ability to perform music. Our protocol excludes cases where performance can be disrupted by motor deficits. The positive cortical sites (the posterior part of the superior temporal gyrus and supramarginal gyrus) related purely to music performance are also reported. Read More

View Article and Full-Text PDF
January 2021

Rare asymptomatic giant cerebral cavernous malformation in adults: two case reports and a literature review.

J Int Med Res 2020 Dec;48(12):300060520926371

Department of Neurosurgery, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Cavernous malformations are benign vascular malformations. Giant cavernous malformations are very rare. All reported cases have been symptomatic because of the large size and compression of the surrounding brain tissue. Read More

View Article and Full-Text PDF
December 2020

Towards linking diffusion MRI based macro- and microstructure measures with cortico-cortical transmission in brain tumor patients.

Neuroimage 2021 02 20;226:117567. Epub 2020 Nov 20.

INRIA, Université Côte d'Azur, France; INRIA, CEA, Université Paris-Saclay, France.

We aimed to link macro- and microstructure measures of brain white matter obtained from diffusion MRI with effective connectivity measures based on a propagation of cortico-cortical evoked potentials induced with intrasurgical direct electrical stimulation. For this, we compared streamline lengths and log-transformed ratios of streamlines computed from presurgical diffusion-weighted images, and the delays and amplitudes of N1 peaks recorded intrasurgically with electrocorticography electrodes in a pilot study of 9 brain tumor patients. Our results showed positive correlation between these two modalities in the vicinity of the stimulation sites (Pearson coefficient 0. Read More

View Article and Full-Text PDF
February 2021

Imaging characteristics of Intrasellar cavernous hemangioma: A case report.

Medicine (Baltimore) 2020 Nov;99(47):e23405

Department of Neurosurgery.

Rationale: Intrasellar cavernous hemangiomas (ICHs) are rare vascular lesions that arise in the sellar region. ICHs are usually misdiagnosed and treated as pituitary adenomas. Therefore, a preoperative diagnosis is particularly important, especially when the goal is complete resection. Read More

View Article and Full-Text PDF
November 2020

Cavernous Hemangioma of the Trochlear Nerve in Asian Population: Case Report and Review of the Literature.

Neurol India 2020 Sep-Oct;68(5):1203-1206

Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Trochlear nerve cavernous hemangioma (CH) is a rare disease. There have been only five such cases reported in the world literature till date. The authors report a case of trochlear nerve CH in the Asian population and review the relevant literature. Read More

View Article and Full-Text PDF
October 2020

Diffusion Tensor Imaging and Tractography Utilized in the Resection of a Midbrain Cavernous Malformation.

Ochsner J 2020 ;20(3):303-306

Department of Neurosurgery, Ochsner Clinic Foundation, New Orleans, LA.

Diffusion tensor imaging (DTI) is a magnetic resonance-based imaging technique that can provide important information about the underlying structure and integrity of the white matter in the brain. Tractography, a DTI postprocessing technique, can provide a detailed model of individual white matter fiber tracts. Knowledge of these tracts may be beneficial in the surgical planning and execution for neurosurgical patients. Read More

View Article and Full-Text PDF
January 2020

Giant cavernous haemangioma in cavernous sinus.

Br J Neurosurg 2020 Sep 22:1-2. Epub 2020 Sep 22.

Pathology Department, Santa Casa of Passos, Passos, Brazil.

The aim of this article is show the neuroimaging, the pathological analysis and makes a brief review regarding to a giant cavernous haemangioma located in cavernous sinus in a 72 years old patient. A brief review was made in the literature searching for the key words "hemangioma" and "cavernous sinus" in the databases PubMed and Scielo for the last ten years. The images addressed were obtained by magnetic resonance imaging (MRI) in FLAIR, T1 and T1-weighted contrast-enhanced. Read More

View Article and Full-Text PDF
September 2020

Morbidity After Symptomatic Hemorrhage of Cerebral Cavernous Malformation: A Nomogram Approach to Risk Assessment.

Stroke 2020 10 21;51(10):2997-3006. Epub 2020 Sep 21.

Department of Neurosurgery (L.M., S.Z., Q.H., H.W., X.Y., X.C., S.W., Y.-L.Z.), Beijing Tiantan Hospital, Capital Medical University, PR China.

Background And Purpose: Symptomatic hemorrhage contributes to an increased risk of repeated bleeding and morbidity in cerebral cavernous malformation (CCM). A better understanding of morbidity after CCM hemorrhage would be helpful to identify patients of higher risk for unfavorable outcome and tailor individualized management.

Methods: We identified 282 consecutive patients who referred to our institute from 2014 to 2018 for CCM with symptomatic hemorrhage and had an untreated follow-up period over 6 months after the first hemorrhage. Read More

View Article and Full-Text PDF
October 2020

Intracranial Capillary Hemangiomas: A Peripartum Presentation and Review of the Literature.

World Neurosurg 2021 01 10;145:220-228. Epub 2020 Sep 10.

Department of Neurosurgery, Froedtert and the Medical College of Wisconsin, Milwaukee, Wisconsin, USA. Electronic address:

Background: Intracranial capillary hemangiomas (ICHs) are rare vascular tumors composed of a bed of many narrow thin-walled vessels. Within the confines of the skull, these tumors can lead to serious neurologic deficits including cranial nerve dysfunction, mood/personality disturbances, and signs of intracranial mass effect.

Methods: We report the case of a 23-year-old, 5-week postpartum woman with a history of progressive painful ophthalmalgia of the right eye presenting with rapid onset of ptosis, diplopia, and right-sided facial pain and hypesthesia. Read More

View Article and Full-Text PDF
January 2021

Transcriptome analysis provides new molecular signatures in sporadic Cerebral Cavernous Malformation endothelial cells.

Biochim Biophys Acta Mol Basis Dis 2020 12 30;1866(12):165956. Epub 2020 Aug 30.

Department of Biomedical, Dental, Morphological and Functional Imaging Sciences, University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy; Department of Biomolecular Strategies, Genetics and Avant-Garde Therapies, I.E.ME.S.T., Via Michele Miraglia, 90139 Palermo, Italy.

Cerebral cavernous malformations (CCM) are lesions affecting brain capillaries that appear with a mulberry-like morphology. This shape results from the enlarged and tangled microvessels having defective endothelial cell junctions, few surrounding pericytes and dense extracellular collagen-rich matrix. Three genes KRIT1, CCM2 and PDCD10 are linked to disease onset. Read More

View Article and Full-Text PDF
December 2020

Multiple cerebral cavernous hemangiomas masquerading as hemorrhagic brain metastases.

Radiol Case Rep 2020 Oct 20;15(10):1973-1977. Epub 2020 Aug 20.

Department of Neurology, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV.

Intracranial hemorrhagic metastases are a relatively common finding in patients with thyroid carcinoma. Consequently, more unusual vascular lesions may be overlooked in contemplating a differential diagnosis in this patient group. A 50-year-old female with previously treated papillary thyroid carcinoma presented to the emergency department following new onset seizures. Read More

View Article and Full-Text PDF
October 2020

NIR-II window tracking of hyperglycemia induced intracerebral hemorrhage in cerebral cavernous malformation deficient mice.

Biomater Sci 2020 Sep 21;8(18):5133-5144. Epub 2020 Aug 21.

Department of Biomedical Engineering, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Second near infrared (NIR-II) window fluorescence imaging between 1000 and 1700 nm with reduced scattering and autofluorescence and deep tissue light penetration allows early and non-invasive determination of vascular pathologies. Here, we demonstrate in vivo NIR-II imaging techniques for tracking hyperglycaemia-induced Intracerebral Hemorrhage (ICH) and Blood Brain Barrier (BBB) hyperpermeability in Cerebral Cavernous Malformation (CCM) deficient mice (CCM1+/-). We synthesised PEGylated AgS quantum dots (QDs) with a bright fluorescent emission peak centred at 1135 nm under an 808 nm NIR light for dynamic imaging of cerebral vasculature in mice and determined the development of ICH and BBB impairment in hyperglycaemic CCM1+/- mice. Read More

View Article and Full-Text PDF
September 2020

Cutaneous venous malformations presenting in an adolescent boy: Cerebral cavernous malformation syndrome.

Pediatr Dermatol 2020 Sep 5;37(5):983-984. Epub 2020 Aug 5.

Princess of Wales Hospital, Bridgend, UK.

Cerebral cavernous malformations (CCM) are collections of enlarged capillaries with irregular structure, located in the brain or spinal cord, that can be life-threatening. We describe a neurologically asymptomatic 15-year-old boy who presented with cutaneous venous malformations (CVM) that developed in adolescence. Owing to his family history of CCM, genetic testing was obtained and confirmed a new mutation in the CCM3 (PDCD10) gene. Read More

View Article and Full-Text PDF
September 2020

Anesthetic Management of Awake Craniotomy for Resection of the Language and Motor Cortex Vascular Malformations.

World Neurosurg 2020 11 28;143:e136-e148. Epub 2020 Jul 28.

Departments of Anesthesiology, Loma Linda University Medical Center, Loma Linda, California, USA. Electronic address:

Background: Although the safety and feasibility of awake craniotomy are well established for epilepsy and brain tumor surgery, its application for resection of vascular lesions, including arteriovenous malformations (AVMs) and cavernomas, is still limited. Apart from the usual challenges of awake craniotomy, vascular lesions pose several additional problems. Our goal is to determine the safety and practicality of awake craniotomy in patients with cerebral vascular malformations located near the eloquent areas, using a refined anesthetic protocol. Read More

View Article and Full-Text PDF
November 2020

Cerebral Cavernous Malformations, Developmental Venous Anomaly, and Its Coexistence: A Review.

Eur Neurol 2020 30;83(4):360-368. Epub 2020 Jul 30.

Tower Health Reading Hospital, West Reading, Pennsylvania, USA.

Background: Cerebral cavernous malformations (CCMs) are intracranial vascular malformations that can exist as a single lesion or mixed vascular lesions. The most common mixed form is the coexistence of CCM with an associated developmental venous anomaly (DVA). In this paper, we aim to give a comprehensive review of CCM, DVA, and their coexistence as mixed lesions. Read More

View Article and Full-Text PDF
February 2021

Familial cerebral cavernous malformation presenting with epilepsy caused by mutation in the CCM2 gene: A case report.

Medicine (Baltimore) 2020 Jul;99(29):e19800

Department of Neurology, Faculty of Medicine, University of Tsukuba, 1-1-1, Tennnoudai, Tsukuba, Ibaraki, 305-8575.

Rationale: Cerebral cavernous malformation (CCM) of the familial type is caused by abnormalities in the CCM1, CCM2, and CCM3 genes. These 3 proteins forming a complex associate with the maintenance of vascular endothelial cell-cell junctions. Dysfunction of these proteins results in the development of hemangiomas and abnormal intercellular junctions. Read More

View Article and Full-Text PDF

Cerebral Cavernous Malformation: What a Practicing Clinician Should Know.

Mayo Clin Proc 2020 09 27;95(9):2005-2020. Epub 2020 Jun 27.

Department of Neurosurgery, Mayo Clinic, Rochester, MN.

Cavernous malformations (CMs) are angiographically occult, low-flow vascular malformations of the central nervous system. They are acquired lesions, with approximately 80% of patients having the sporadic form and 20% the familial form of the disease. The lesions may also develop years after radiotherapy. Read More

View Article and Full-Text PDF
September 2020

Multiple cerebral cavernous malformations in association with a Dubowitz-like syndrome.

J Cerebrovasc Endovasc Neurosurg 2020 Mar 31;22(1):15-19. Epub 2020 Mar 31.

Department of Neurosurgery, Royal Preston Hospital, Lancashire Teaching Hospitals NHS Trust, Preston, PR2 9HT, UK.

Cerebral cavernous malformations (CCMs) are proliferative sinusoidal vascular lesions and are the most common vascular malformations of the brain. They can occur sporadically or secondary to an underlying genetic predisposition where multiple lesions are commonly seen. Dubowitz syndrome is a clinically-diagnosed rare genetic disorder with an unknown molecular basis. Read More

View Article and Full-Text PDF

Awake Craniotomy with Cortical and Subcortical Speech Mapping for Supramarginal Cavernoma Resection.

World Neurosurg 2020 09 22;141:260. Epub 2020 Jun 22.

Department of Neurologic Surgery, Mayo Clinic, Jacksonville, Florida, USA. Electronic address:

Awake craniotomy allows mapping of eloquent brain regions and monitoring neurocognitive functioning intraoperatively to maximize extent of resection and minimize cognitive morbidity. During resection of cavernous malformations in eloquent areas, intraoperative cognitive monitoring can also allow for safer maximal excision of the hemosiderin ring, which is correlated with improved seizure-free outcome. We present the case of a 33-year-old right-handed male with a new-onset seizure who presented to his local emergency department after experiencing visual hallucinations before losing consciousness. Read More

View Article and Full-Text PDF
September 2020