99 results match your criteria Brain Imaging in Capillary Telangiectasia


CT-Negative Subarachnoid Hemorrhage Caused by Telangiectasia: A Case Report.

Curr Med Imaging 2021 Jun 8. Epub 2021 Jun 8.

Department of Neurology, China-Japan Union Hospital of Jilin University, China.

Introduction: At present, the mechanism of telangiectasia is unknown, but some evidence suggests that it may be related to genetic abnormalities. Telangiectasia may lead to bleeding of multiple sites. CT-negative subarachnoid hemorrhage is rare, which is mostly related to hemorrhage with a little amount of bleeding. Read More

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Susceptibility-weighted Imaging: Technical Essentials and Clinical Neurologic Applications.

Radiology 2021 Apr 23;299(1):3-26. Epub 2021 Feb 23.

From the CIRD Centre d'Imagerie Rive Droite, Geneva, Switzerland (S.H.); Faculty of Medicine of the University of Geneva, Geneva, Switzerland (S.H.); Department of Surgical Sciences, Division of Radiology, Uppsala University, Uppsala, Sweden (S.H.); CIMC Centre d'Imagerie Médicale de Cornavin, Geneva, Switzerland (S.H.) Departments of Neurology and Radiology, Wayne State University, Detroit, Mich (E.M.H.); Department of Biomedical Imaging and Image-guided Therapy, Medical University Vienna, Vienna, Austria (M.M.T.); Queen Square Institute of Neurology, University College London, London, England (F.B.); Centre for Medical Image Computing (CMIC), Institute of Healthcare Engineering, University College London, London, England (F.B.); and Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centre, Amsterdam, the Netherlands (F.B.).

Susceptibility-weighted imaging (SWI) evolved from simple two-dimensional T2*-weighted sequences to three-dimensional sequences with improved spatial resolution and enhanced susceptibility contrast. SWI is an MRI sequence sensitive to compounds that distort the local magnetic field (eg, calcium and iron), in which the phase information can differentiate. But the term is colloquially used to denote high-spatial-resolution susceptibility-enhanced sequences across different MRI vendors and sequences even when phase information is not used. Read More

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Pulmonary arteriovenous malformation managed by VATS lobectomy.

Rozhl Chir 2020 ;99(10):467-471

Pulmonary arteriovenous malformation (PAVM) is formed by abnormal connections between pulmonary arteries and veins that bypass the pulmonary capillaries and transport deoxygenated blood through pulmonary veins to the left heart. This causes insufficient oxygenation of blood in the lungs. This condition remains symptomless for a long period of time. Read More

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November 2020

A rare case of occlusive juxtafoveolar retinal telangiectasias associated with lesions of the central nervous system: A cerebroretinal vasculopathy like phenotype without mutations in the TREX1 gene.

Am J Ophthalmol Case Rep 2020 Dec 27;20:100985. Epub 2020 Oct 27.

West Virginia University Eye Institute, 1 Medical Center Dr, Morgantown, WV, 26506, USA.

Purpose: To report a rare case of bilateral occlusive juxtafoveolar retinal telangiectasias associated with central nervous system lesions and renal impairment.

Observations: A 47-year-old woman presented to clinic with subjective vision loss in the right eye with best-corrected visual acuity (BCVA) 20/80. Fundoscopic examination, fluorescein angiography (FA), and optical coherence tomography with adjunct angiography (OCT/OCT-A) revealed macular microhemorrhages, enlarged foveal avascular zones (FAZ), and occlusive juxtafoveal telangiectasis with pruning of the macular capillaries in both eyes. Read More

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December 2020

Appearance of an unusual ring enhancing brain capillary telangiectasia on 3.0T MRI with dynamic susceptibility contrast perfusion.

Radiol Case Rep 2020 Aug 23;15(8):1331-1334. Epub 2020 Jun 23.

Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Road, Suite BG23, Atlanta, GA 30322, USA.

We present the appearance of brain capillary telangiectasia on 3.0T magnetic resonance imaging (MRI) perfusion. A 42-year-old female presented with intermittent left arm weakness and paresthesia. Read More

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Brain capillary telangiectasias: from normal variants to disease.

Acta Neurochir (Wien) 2020 05 6;162(5):1101-1113. Epub 2020 Mar 6.

Mayo Clinic Department of Radiology, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA.

Background: Brain capillary telangiectasias (BCTs) are small, dilated capillary networks in the brain that are most commonly asymptomatic. Though rare, symptomatic cases of BCTs have been reported, and it is therefore important to understand the nature of these lesions in order to facilitate proper recognition. Relative to other intracranial vascular malformations, updated information on the various epidemiologic, radiographic, and pathologic features of BCTs within the published literature may be inadequate. Read More

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Supracerebellar Approach to Radiation-Induced Giant Capillary Telangiectasia Within Juvenile Pilocytic Astrocytoma of Upper Brainstem.

World Neurosurg 2019 Dec 31;132:57. Epub 2019 Aug 31.

Skull Base and Cerebrovascular Laboratory, University of California, San Francisco, California, USA; Department of Neurological Surgery, University of California, San Francisco, California, USA. Electronic address:

Radiation-induced telangiectasia of the central nervous system has been described predominantly in children, with up to 20% of patients affected after 3-41 years of radiotherapy. We present the case of a 45-year-old male with a pontine pilocytic astrocytoma treated with standard-dose radiation for 6 weeks in 1993. He developed a 3-cm multicystic, hemorrhagic brainstem lesion but was asymptomatic. Read More

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December 2019

Paradoxical Brain Embolism Caused by Isolated Pulmonary Arteriovenous Fistula Successfully Treated with Recombinant Tissue Plasminogen Activator.

J Stroke Cerebrovasc Dis 2019 Jul 18;28(7):e100-e101. Epub 2019 Apr 18.

Department of Neurology, Osaka City University Graduate School of Medicine, Osaka City, Japan.

Pulmonary arteriovenous fistula (PAVF), a vessel malformation connecting the pulmonary circulation to the systemic circulation while bypassing the pulmonary capillaries, can cause paradoxical cerebral infarction. It is often associated with hereditary hemorrhagic telangiectasia (HHT), a genetic disease characterized by multiple dermal, mucosal, and visceral telangiectasia causing recurrent bleeding. Paradoxical cerebral embolism caused by PAVF without HHT is rare. Read More

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[Robot-Assisted Laparoscopic Prostatectomy for Patient with Hereditary Hemorrhagic Telangiectasia: A Case Report].

Hinyokika Kiyo 2018 Dec;64(12):505-508

The Department of Urology, Nara Prefecture General Medical Center.

A 69-year-old man who had a history of several nasal hemorrhages and transfusions presented with hereditary hemorrhagic telangiectasia. He was referred to the previous hospital due to the elevation of prostate specific antigen (PSA) to 17.2 ng/ml, and was diagnosed with prostate cancer (cT3aN0M0, Gleason 4 + 5). Read More

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December 2018

Hereditary Hemorrhagic Telangiectasia - Early Childhood Presentation with Hepatic Failure.

J Coll Physicians Surg Pak 2018 Sep;28(9):S195-S197

Department of Pediatrics, Shifa College of Medicine, Islamabad.

Hereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia in which capillary bed is absent with direct draining of arterial blood into venous circulation. Due to increased pressure there is increased risk of bleeding. The classical triad consists of telangiectasias, epistaxis and a positive family history. Read More

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September 2018

Pulmonary arteriovenous malformations: diagnosis.

Cardiovasc Diagn Ther 2018 Jun;8(3):325-337

Department of Radiology, UT Southwestern Medical Center, Dallas, Texas, USA.

Pulmonary arteriovenous malformations (PAVMs) are rare, abnormal low resistance vascular structures that connect a pulmonary artery to a pulmonary vein, thereby bypassing the normal pulmonary capillary bed and resulting in an intrapulmonary right-to-left shunt. The spectrum of PAVMs extends from microscopic lesions causing profound hypoxemia and ground glass appearance on computed tomography (CT) but with normal catheter angiographic findings to classic pulmonary aneurysmal connections that abnormally connect pulmonary veins and arteries. These malformations most commonly are seen in hereditary hemorrhagic telangiectasia (HHT). Read More

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Metabolic Changes of Brain Developmental Venous Anomalies on F-FDG-PET.

Acad Radiol 2019 04 28;26(4):443-449. Epub 2018 Jun 28.

Department of Neuroradiology, Hospital of the University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104. Electronic address:

Rationale And Objectives: To determine the metabolic effects of developmental venous anomalies (DVAs) and to correlate those effects with conventional magnetic resonance imaging (MRI) findings.

Materials And Methods: We conducted a retrospective review of MRI and brain 18F-fluorodeoxyglucose positron emission tomography (F-FDG-PET) examinations in subjects with DVAs. Conventional MRI was used to determine DVA number, location, size, and associated parenchymal findings such as atrophy, hemorrhage, cavernoma, capillary telangiectasia, cortical dysplasia/polymicrogyria, and white matter signal abnormality. Read More

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Eight-and-a-Half Syndrome: A Combination of Intracranial Capillary Telangiectasia and Hematencephalon.

J Stroke Cerebrovasc Dis 2018 Jul 12;27(7):e135-e137. Epub 2018 Apr 12.

Department of Nerve medical center, The First Hospital of Changsha, Changsha, China.

Eight-and-a-half syndrome, a combination of one-and-a-half syndrome and ipsilateral facial palsy, was first described by Eggenberger in 1998. Intracranial capillary telangiectasia (ICT) is a rare type of latent cerebral vascular malformation characterized by a number of small, dilated, and thin-walled blood capillaries with normal brain tissues between them. Susceptibility weighted imaging is the recommended diagnostic method to detect ICT. Read More

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Optical coherence tomography angiography: A comprehensive review of current methods and clinical applications.

Prog Retin Eye Res 2017 09 29;60:66-100. Epub 2017 Jul 29.

Department of Biomedical Engineering, University of Washington Seattle, Seattle, WA 98195, United States.

OCT has revolutionized the practice of ophthalmology over the past 10-20 years. Advances in OCT technology have allowed for the creation of novel OCT-based methods. OCT-Angiography (OCTA) is one such method that has rapidly gained clinical acceptance since it was approved by the FDA in late 2016. Read More

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September 2017

Pial Arteriovenous Fistula and Capillary Malformation-Arteriovenous Malformation Associated with RASA1 Mutation: 2 Pediatric Cases with Successful Surgical Management.

Pediatr Neurosurg 2017 31;52(4):261-267. Epub 2017 May 31.

Division of Pediatric Epilepsy, Department of Pediatric Neurology, Rainbow Babies and Children's Hospital, and Department of Neurology and Neurosurgery, The Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

We present case reports of 2 pediatric patients who were both found to have pial arteriovenous fistulas (AVFs) with subsequent genetic analysis revealing mutations in the RASA1 gene. Considering their family history of distinct cutaneous lesions, these mutations were likely inherited as opposed to de novo mutations. Patient 1 had large capillary malformations on the left side of the face and neck, associated with macrocephaly, and presented at the age of 32 months with speech delay, right-sided weakness, and focal seizures involving the right side of the body. Read More

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Cerebral Abscess Associated With Odontogenic Bacteremias, Hypoxemia, and Iron Loading in Immunocompetent Patients With Right-to-Left Shunting Through Pulmonary Arteriovenous Malformations.

Clin Infect Dis 2017 08;65(4):595-603

NHLI Cardiovascular Sciences, Imperial College London, London, UK.

Background: Cerebral abscess is a recognized complication of pulmonary arteriovenous malformations (PAVMs) that allow systemic venous blood to bypass the pulmonary capillary bed through anatomic right-to-left shunts. Broader implications and mechanisms remain poorly explored.

Methods: Between June 2005 and December 2016, at a single institution, 445 consecutive adult patients with computed tomography-confirmed PAVMs (including 403 [90. Read More

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Symptomatic capillary telangiectasia of the pons: three pediatric cases diagnosed by suspectibility-weighted imaging.

Childs Nerv Syst 2016 Nov 19;32(11):2261-2264. Epub 2016 May 19.

Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Besevler, 06510, Ankara, Turkey.

Introduction: Brain capillary telangiectasias (BCT) are small, clinically benign, usually asymptomatic and rarely seen lesions during childhood. Large symptomatic BCT during childhood are extremely rare, with only a few reports in the literature. They usually cannot be detected easily on conventional magnetic resonance imaging and angiography. Read More

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November 2016

Vascular Disorders of the Cerebellum in Children.

Neuroimaging Clin N Am 2016 Aug;26(3):435-58

Department of Radiology, Mount Sinai Medical Center, Box 1234, One Gustave Levy Place, New York, NY 10029, USA; Department of Neurosurgery, Mount Sinai Medical Center, One Gustave Levy Place, New York, NY 10029, USA; Department of Pediatrics, Mount Sinai Medical Center, One Gustave Levy Place, New York, NY 10029, USA.

Key differences exist in the epidemiology, pathophysiology, and clinical presentation of vascular lesions of the cerebellum in children versus adults. An understanding of these differences and an appreciation of the distinct imaging features of these lesions aid in distinguishing normal vascular variations from pathology, in predicting lesion etiology, and in directing effective treatment strategies. This paper reviews the embryogenesis of the normal vascular system of the cerebellum and brainstem and then discusses the clinical and imaging features of the common vascular lesions affecting these structures in the pediatric population. Read More

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Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing-like attacks in a pediatric patient found to have a pontine capillary telangiectasia and developmental venous anomaly: A case report exploring the root of the problem.

Cephalalgia 2017 Oct 24;37(11):1093-1097. Epub 2016 Jun 24.

1 Department of Pediatric Neurology, University of Alberta, Edmonton, AB, Canada.

Introduction Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)-like attacks are rarely reported in the pediatric population and may remain undiagnosed and under-investigated as a result. Case presentation We present a case of a 15-year-old male with intermittent, episodic, right-sided brief headaches most in keeping with SUNCT, initially diagnosed as paroxysmal hemicrania, but with no response to indomethacin. The pain was likewise not responsive to typical migraine treatments or steroids. Read More

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October 2017

Severe holocord syrinx in a child with megalencephaly-capillary malformation syndrome.

J Neurosurg Pediatr 2016 Jul 1;18(1):79-82. Epub 2016 Apr 1.

Departments of 1 Neurology.

The authors present the case of a child with megalencephaly-capillary malformation syndrome who developed a rapidly progressive holocord syringomyelia that was treated surgically. A 3-year-old boy with megalencephaly-capillary malformation-polymicrogyria (MCAP) syndrome presented with several months of right leg weakness, worsening scoliosis, and increased seizures. An MRI study of the brain demonstrated a Chiari I malformation and massively dilated syringomyelia extending from C-2 to the conus medullaris. Read More

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Neurovascular Manifestations of Hereditary Hemorrhagic Telangiectasia: A Consecutive Series of 376 Patients during 15 Years.

AJNR Am J Neuroradiol 2016 Aug 24;37(8):1479-86. Epub 2016 Mar 24.

From the Departments of Radiology (W.B., H.J.C., K.R.T., C.P.W.).

Background And Purpose: Hereditary hemorrhagic telangiectasia is associated with a wide range of neurovascular abnormalities. The aim of this study was to characterize the spectrum of cerebrovascular lesions, including brain arteriovenous malformations, in patients with hereditary hemorrhagic telangiectasia and to study associations between brain arteriovenous malformations and demographic variables, genetic mutations, and the presence of AVMs in other organs.

Materials And Methods: Consecutive patients with definite hereditary hemorrhagic telangiectasia who underwent brain MR imaging/MRA, CTA, or DSA at our institution from 2001 to 2015 were included. Read More

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Natural history of brain capillary vascular malformations in hereditary hemorrhagic telangiectasia patients.

J Neurointerv Surg 2017 Jan 26;9(1):26-28. Epub 2016 Feb 26.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Background And Purpose: Brain capillary vascular malformations (CVMs) are known to occur with relatively high frequency in hereditary hemorrhagic telangiectasia (HHT) patients. These lesions are thought to have a benign natural history but this has not been systematically studied. The purpose of our study was to examine the natural history of CVMs in a consecutive series of HHT patients. Read More

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January 2017

Symptomatic large or giant capillary telangiectasias: management and outcome in 5 cases.

J Neurosurg 2016 07 13;125(1):160-6. Epub 2015 Nov 13.

Departments of 1 Neurosurgery and.

Brain capillary telangiectasias (BCTs) are usually small and benign with a predilection in the pons and basal ganglion. Reports of large and symptomatic BCTs are rare. Large BCTs have a much higher risk of causing uncontrolled bleeding and severe neurological defects, and they can be fatal if left untreated. Read More

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Pediatric central nervous system vascular malformations.

Pediatr Radiol 2015 Sep 7;45 Suppl 3:S463-72. Epub 2015 Sep 7.

Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.

Pediatric central nervous system (CNS) vascular anomalies include lesions found only in the pediatric population and also the full gamut of vascular lesions found in adults. Pediatric-specific lesions discussed here include infantile hemangioma, vein of Galen malformation and dural sinus malformation. Some CNS vascular lesions that occur in adults, such as arteriovenous malformation, have somewhat distinct manifestations in children, and those are also discussed. Read More

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September 2015

Giant symptomatic capillary telangiectasia of the brain.

Arq Neuropsiquiatr 2015 Jan 1;73(1):66-7. Epub 2015 Jan 1.

Departamento de Radiologia, Universidade de São Paulo, Sao Paulo, SP, Brazil.

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January 2015

Capillary telangiectasia of the brain: imaging with various magnetic resonance techniques.

JBR-BTR 2014 Jul-Aug;97(4):233-8

Department of Radiology, İzmir Kâtip Çelebi Üniversitesi Atatürk Eğitim ve Araştirma Hastanesi, Basin Sitesi, Izmir, Turkey.

Brain capillary telangiectasia is an incidental vascular malformation found usually in pons and sometimes in extra- pontine sites. Typical MRI features are enhancement on post contrast T1 weighted images and signal loss on gradient echo images. We evaluated 10 patients with various MR techniques. Read More

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February 2015

Neurovascular manifestations in hereditary hemorrhagic telangiectasia: imaging features and genotype-phenotype correlations.

AJNR Am J Neuroradiol 2015 May 8;36(5):863-70. Epub 2015 Jan 8.

From the Division of Neuroradiology (T.K., S.P., K.G.t.B.), Department of Medical Imaging.

Background And Purpose: Hereditary hemorrhagic telangiectasia is an autosomal dominant disease that presents in 10%-20% of patients with various brain vascular malformations. We aimed to report the radiologic features (phenotype) and the genotype-phenotype correlations of brain vascular malformations in hereditary hemorrhagic telangiectasia.

Materials And Methods: Demographic, clinical, genotypic, and imaging information of 75 patients with hereditary hemorrhagic telangiectasia with brain arteriovenous malformations enrolled in the Brain Vascular Malformation Consortium from 2010 to 2012 were reviewed. Read More

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Genetic markers and their influence on cerebrovascular malformations.

Neuroimaging Clin N Am 2015 Feb;25(1):69-82

UNC at Chapel Hill, Chapel Hill, NC 27516, USA. Electronic address:

Cerebrospinal vascular malformations are a group of anomalies affecting the arterial wall, the capillary arteriovenous interface, or the venous and lymphatic structures. Heritability and family studies allow identification of mutations in single genes associated with rare familial conditions causing cerebral or spinal vascular malformations, as is the case in hemorrhagic hereditary telangiectasia diseases. This article reviews the genetic and epigenetic influences increasingly reported in recent years as causal factors or triggers involved in the formation and growth of cerebromedullary vascular malformations. Read More

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February 2015

Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.

Proc Natl Acad Sci U S A 2014 Dec 2;111(50):18007-12. Epub 2014 Dec 2.

Laboratory for Accelerated Vascular Research, Department of Surgery, Division of Vascular Surgery, University of California, San Francisco, CA 94143;

Arteriovenous (AV) malformation (AVM) is a devastating condition characterized by focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. AVMs can form anywhere in the body and can cause debilitating ischemia and life-threatening hemorrhagic stroke. The mechanisms that underlie AVM formation remain poorly understood. Read More

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December 2014