7,700 results match your criteria Brain Imaging in Astrocytoma


The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.

Childs Nerv Syst 2019 Feb 15. Epub 2019 Feb 15.

Department of Paediatric Oncology, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK.

Objectives: Paediatric cerebellar pilocytic astrocytomas (PA) (WHO grade 1) are amongst the most common of childhood brain tumours and are generally amenable to resection, with surgery alone being curative in the majority of cases. There is, however, a lack of consensus regarding the frequency and duration of post-treatment MRI surveillance for these tumours. This is important, as follow-up imaging is a significant use of resources and often associated with patient and family anxiety. Read More

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http://dx.doi.org/10.1007/s00381-019-04078-3DOI Listing
February 2019

Atypical Presentation of Glioblastoma Multiforme.

Eur J Case Rep Intern Med 2018 27;5(9):000954. Epub 2018 Sep 27.

Neurology Department, Henry Ford Health System, Detroit, MI, USA.

Background: Glioblastoma multiforme (GBM) is a highly malignant glial tumour classified by the World Health Organization (WHO) as a stage IV astrocytoma. It varies in shape and size and can be cystic, vascular and necrotic. It often appears as a ring-enhancing lesion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.12890/2018_000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346815PMC
September 2018

Outcomes Following Proton Therapy for Pediatric Low-Grade Glioma.

Int J Radiat Oncol Biol Phys 2019 Jan 23. Epub 2019 Jan 23.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL.

Background/objectives: Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is the 4th most common pediatric tumor treated with proton therapy, yet clinical outcome data on efficacy and toxicity are limited.

Design/methods: We reviewed the medical records of 174 children (≤21 years old) with non-metastatic LGG enrolled on a prospective protocol and treated with proton therapy between 2007 and 2017 to assess clinical outcomes and toxicity, and analyze patient, tumor, and treatment-related variables. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.01.078DOI Listing
January 2019
16 Reads

Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management.

J Med Imaging Radiat Oncol 2019 Jan 24. Epub 2019 Jan 24.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Introduction: Assess survival of patients with anaplastic glioma (AG) and the relationship to molecular subtype.

Methods: Patients with AG managed with IMRT between 2008 and 2014 were entered into a prospective database assessing relapse-free survival (RFS) and overall survival (OS). Isocitrate dehydrogenase (IDH) mutations were assessed prospectively from 2011, and subsequent testing of historical patients allowing categorisation under WHO 2016 classification as anaplastic astrocytoma IDH wild type (AAwt), anaplastic astrocytoma IDH mutated (AAmut), anaplastic oligodendroglioma (AOD) or other glial tumour (OTH). Read More

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http://dx.doi.org/10.1111/1754-9485.12850DOI Listing
January 2019
2 Reads

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
5 Reads

Papillary glioblastoma exhibiting a neuroradiological cyst with a mural nodule: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14102

Division of Human Pathology, Department of Pathology and Microbiology.

Rationale: Glioblastomas are malignant, infiltrating gliomas classified as grade IV by the World Health Organization. Genetically, most glioblastomas do not exhibit the isocitrate dehydrogenase (IDH) 1/2 gene mutation and rarely harbor the 1p/19q co-deletion. Neuroradiologically, glioblastomas rarely form a cyst with a mural nodule lesion. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901110-0007
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http://dx.doi.org/10.1097/MD.0000000000014102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336597PMC
January 2019
2 Reads

Tissue-type mapping of gliomas.

Neuroimage Clin 2018 Dec 25:101648. Epub 2018 Dec 25.

Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address:

Purpose: To develop a statistical method of combining multimodal MRI (mMRI) of adult glial brain tumours to generate tissue heterogeneity maps that indicate tumour grade and infiltration margins.

Materials And Methods: We performed a retrospective analysis of mMRI from patients with histological diagnosis of glioma (n = 25). H Magnetic Resonance Spectroscopic Imaging (MRSI) was used to label regions of "pure" low- or high-grade tumour across image types. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.101648DOI Listing
December 2018
1 Read

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas.

Pol J Radiol 2018 10;83:e197-e203. Epub 2018 May 10.

Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Purpose: Haemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.

Material And Methods: The study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.75870
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http://dx.doi.org/10.5114/pjr.2018.75870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323599PMC
May 2018
4 Reads

Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature.

Pediatr Neurosurg 2019 Jan 8:1-10. Epub 2019 Jan 8.

Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia,

Background: Gangliogliomas are low-grade neoplasms that typically affect patients under the age of 30 and present with epilepsy and symptoms of mass effect. Here, we report a case of an intraventricular ganglioglioma involving the septum pellucidum in a pediatric patient with history of optic glioma. Only one other pediatric intraventricular ganglioglioma arising from the septum pellucidum has been reported previously. Read More

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https://www.karger.com/Article/FullText/495043
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http://dx.doi.org/10.1159/000495043DOI Listing
January 2019
11 Reads
0.497 Impact Factor

Conventionally fractionated stereotactic radiotherapy (CFRT) in combination with dose-dense temozolomide (TMZ) in relapsed malignant glioma: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e13869

Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei, P.R. China.

Rationale: At present, there is no uniform consensus on the treatment of recurrent glioblastoma, especially the re-irradiation dose and temozolomide (TMZ) dose. The literature on the treatment of recurrent glioblastoma (GBM) by conventionally fractionated stereotactic radiotherapy (CFRT) is even rarer.

Patient Concerns: A 44-year-old woman was admitted to our hospital for residual tumor after reoperation. Read More

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http://dx.doi.org/10.1097/MD.0000000000013869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344191PMC
January 2019
1 Read

Intraventricular Pilocytic Astrocytoma With KIAA1549/BRAF Fusion Arising in a 44-Year Old.

J Neuropathol Exp Neurol 2019 Feb;78(2):187-190

Department of Pathology, Duke University, Durham, North Carolina.

Rare pilocytic astrocytomas (PA) have been described to arise in the ventricles of children. They are even less common in this location for the adult population. We present the case of a 44-year old man presenting with vision and mental status changes. Read More

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http://dx.doi.org/10.1093/jnen/nly116DOI Listing
February 2019
1 Read

Grading and proliferation assessment of diffuse astrocytic tumors with monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging and diffusion kurtosis imaging.

Eur J Radiol 2018 Dec 5;109:188-195. Epub 2018 Nov 5.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Purpose: To compare the main parameters derived from monoexponential, biexponential and stretched-exponential diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) with respect to diagnostic performance for tumor grading and proliferation assessment in diffuse astrocytic tumors (DATs).

Materials And Methods: Fifty-eight pathologically confirmed DAT patients who underwent DWI and DKI on a 3-T scanner were prospectively collected and retrospectively reviewed. Measurements including the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D), perfusion fraction (f), distributed diffusion coefficient (DDC), heterogeneity index (α), mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) were compared between tumor grades (Ⅱ, Ⅲ, and Ⅳ) by using a Jonckheere-Terpstra test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183039
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http://dx.doi.org/10.1016/j.ejrad.2018.11.003DOI Listing
December 2018
8 Reads

Diffusion Kurtosis Imaging Reflects Glial Fibrillary Acidic Protein (GFAP), Topo IIα, and O⁶-Methylguanine-DNA Methyltransferase (MGMT) Expression in Astrocytomas.

Med Sci Monit 2018 Dec 6;24:8822-8830. Epub 2018 Dec 6.

Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China (mainland).

BACKGROUND Astrocytomas are the most common primary brain neoplasms. Biological indicators of astrocytomas can reflect its biological characteristics. The aim of this study was to assess the expression of the pathological glial fibrillary acidic protein (GFAP) Topo IIα and O⁶-methylguanine-DNA methyltransferase (MGMT) in astrocytomas using magnetic resonance (MR) diffusion kurtosis imaging (DKI) to evaluate the biological characteristics of astrocytomas. Read More

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https://www.medscimonit.com/abstract/index/idArt/911631
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http://dx.doi.org/10.12659/MSM.911631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292149PMC
December 2018
9 Reads

Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Two techniques, the translongitudinal cerebral fissure and transfrontal cortical approach, can be employed to resect posterior cingulate gyrus tumors. We demonstrate the transcortical technique comprising of multimodal imaging guidance and awake brain mapping which enabled maximum safe resection of dominant cingulate gyrus glioma. The patient, a 49-yr-old female, came to clinic after experiencing headache for a month. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy347DOI Listing
November 2018
13 Reads

COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies.

BMC Bioinformatics 2018 Nov 26;19(1):453. Epub 2018 Nov 26.

Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden.

Background: Large-scale pairwise drug combination analysis has lately gained momentum in drug discovery and development projects, mainly due to the employment of advanced experimental-computational pipelines. This is fortunate as drug combinations are often required for successful treatment of complex diseases. Furthermore, most new drugs cannot totally replace the current standard-of-care medication, but rather have to enter clinical use as add-on treatment. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2458-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257977PMC
November 2018
12 Reads

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.

Nat Commun 2018 11 21;9(1):4904. Epub 2018 Nov 21.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier, heterogeneous drug distribution, and development of resistance. Elucidation of relationships among such parameters could enable the development of predictive models of drug response in patients and inform drug development. Read More

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http://dx.doi.org/10.1038/s41467-018-07334-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249307PMC
November 2018
8 Reads

Pilocytic Astrocytoma with Gangliocytic Differentiation to Pilomyxoid Astrocytoma-expanding the Morphological Spectrum: Case Report and Literature Review.

Asian J Neurosurg 2018 Oct-Dec;13(4):1193-1196

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

We present a rare case of pilocytic astrocytoma (PA) with gangliocytic differentiation arising in the suprasellar/chiasmatic region in a young boy that showed a rapid regrowth after the 1 subtotal resection and "differentiated" into pilomyxoid astrocytoma (PMA) in subsequent recurrences. The clinical course, imaging, and histological features have been described with a review of the literature. While PA is well-circumscribed, biphasic tumors with bipolar piloid cells, those arising in the diencephalic region often contain myxoid stroma, angiocentric pattern, and "intermediate" features between PA and PMA. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_247_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208220PMC
November 2018
10 Reads

A malignant astrocytoma with uncommon angiocentric features and dot-like EMA expression.

Contemp Oncol (Pozn) 2018 30;22(3):205-208. Epub 2018 Sep 30.

Department of Pathology, Chair of Oncology, Medical University of Lodz, Poland.

Angiocentric features are uncommon in high-grade World Health Organisation (WHO) brain tumours, whilst they are typical for WHO grade I tumours, e.g. angiocentric gliomas. Read More

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https://www.termedia.pl/doi/10.5114/wo.2018.78944
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http://dx.doi.org/10.5114/wo.2018.78944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238096PMC
September 2018
9 Reads

Overall survival prediction in glioblastoma multiforme patients from volumetric, shape and texture features using machine learning.

Surg Oncol 2018 Dec 10;27(4):709-714. Epub 2018 Sep 10.

National University of Singapore, Singapore. Electronic address:

Glioblastoma multiforme (GBM) are aggressive brain tumors, which lead to poor overall survival (OS) of patients. OS prediction of GBM patients provides useful information for surgical and treatment planning. Radiomics research attempts at predicting disease prognosis, thus providing beneficial information for personalized treatment from a variety of imaging features extracted from multiple MR images. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.09.002DOI Listing
December 2018

Tumour volume reduction following PET guided intensity modulated radiation therapy and temozolomide in IDH mutated anaplastic glioma.

J Clin Neurosci 2019 Jan 14;59:68-74. Epub 2018 Nov 14.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Sydney NeuroOncology Group, Sydney, Australia.

The role of maximal surgical debulking in isocitrate dehydrogenase (IDH) mutated anaplastic glioma prior to adjuvant radiation therapy remains uncertain. This study assessed the reduction in tumour volume following intensity modulated radiation therapy (IMRT) and temozolomide in this favourable and more responsive tumour pathology. 56 patients were managed from 2011 to 2014 and 53 had residual disease. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.005DOI Listing
January 2019
3 Reads

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments.

Cureus 2018 Sep 10;10(9):e3272. Epub 2018 Sep 10.

Surgery/Neurosurgery, University of Toledo Medical Center, Toledo, USA.

Glioblastoma multiforme (GBM) is a World Health Organization (WHO) grade IV primary malignant astrocytoma. Aneurysms are devastating intracranial neurovascular pathologies. Intracranial dermoid cysts are common, benign lesions which can be clinically silent or associated with seizure disorder. Read More

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https://www.cureus.com/articles/12761-long-term-seizure-diso
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http://dx.doi.org/10.7759/cureus.3272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235633PMC
September 2018
10 Reads

Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior.

Pediatr Neurosurg 2018 14;53(6):395-400. Epub 2018 Nov 14.

Children's Hospital LA, Los Angeles, California, USA.

Background/aims: Pilocytic astrocytomas are common pediatric tumors. Molecular profiles vary with location of origin. Comparisons of proliferation have not been reported. Read More

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http://dx.doi.org/10.1159/000490466DOI Listing
January 2019
10 Reads

Nanotechnology for Treatment of Glioblastoma Multiforme.

J Transl Int Med 2018 Sep 9;6(3):128-133. Epub 2018 Oct 9.

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Glioblastoma multiforme (GBM), a grade IV astrocytoma as defined by the World Health Organization (WHO) criteria, is the most common primary central nervous system tumor in adults. After treatment with the current standard of care consisting of surgical resection, concurrent temozolomide (TMZ), and radiation, the median survival is only 15 months. The limited and less-effective treatment options for these highly aggressive GBMs call for the development of new techniques and the improvement of existing technologies. Read More

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https://content.sciendo.com/view/journals/jtim/6/3/article-p
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http://dx.doi.org/10.2478/jtim-2018-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231306PMC
September 2018
7 Reads

Differentiation between pilocytic astrocytoma and glioblastoma: a decision tree model using contrast-enhanced magnetic resonance imaging-derived quantitative radiomic features.

Eur Radiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Objective: To differentiate brain pilocytic astrocytoma (PA) from glioblastoma (GBM) using contrast-enhanced magnetic resonance imaging (MRI) quantitative radiomic features by a decision tree model.

Methods: Sixty-six patients from two centres (PA, n = 31; GBM, n = 35) were randomly divided into training and validation data sets (about 2:1). Quantitative radiomic features of the tumours were extracted from contrast-enhanced MR images. Read More

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http://link.springer.com/10.1007/s00330-018-5706-6
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http://dx.doi.org/10.1007/s00330-018-5706-6DOI Listing
November 2018
10 Reads
4.014 Impact Factor

Machine learning based on multi-parametric magnetic resonance imaging to differentiate glioblastoma multiforme from primary cerebral nervous system lymphoma.

Eur J Radiol 2018 Nov 14;108:147-154. Epub 2018 Sep 14.

Department of Diagnostic Radiology, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuoku, Kumamoto, 860-8556, Japan. Electronic address:

Purpose: To evaluate the performance of a machine learning method based on texture features in multi-parametric magnetic resonance imaging (MRI) to differentiate a glioblastoma multiforme (GBM) from a primary cerebral nervous system lymphoma (PCNSL).

Materials And Methods: We included 70 patients who underwent contrast enhanced brain MRI at 3 T with brain tumors diagnosed as GBM (n = 45) and PCNSL (n = 25) in this retrospective study. Twelve histograms and texture parameters were assessed on T2-weighted images (T2WIs), apparent diffusion coefficient maps, relative cerebral blood volume (rCBV) map, and contrast-enhanced T1-weighted images (CE-T1WIs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183032
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http://dx.doi.org/10.1016/j.ejrad.2018.09.017DOI Listing
November 2018
12 Reads

Ictal SPECT reveals different epileptogenic zones in frontal lobe epilepsy.

Epileptic Disord 2018 Oct;20(5):447-450

Epilepsy Center, Department of Neurology, University of Munich, Munich, Germany.

We report a patient with frontal lobe epilepsy due to a right frontal astrocytoma (WHO Grade III) in whom two ictal SPECTs (single photon emission tomography) were performed during two seizures with different semiology and different EEG seizure patterns. Subtraction of ictal and interictal SPECT showed right lateral frontal hyperperfusion during a left face clonic seizure, and right mesial fronto-polar hyperperfusion during a subclinical seizure. This report demonstrates that ictal SPECT may reflect different seizure semiology from the frontal lobe of the same individual and that simultaneous EEG is indispensable for the correct interpretation of SPECT in epilepsy. Read More

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http://dx.doi.org/10.1684/epd.2018.0991DOI Listing
October 2018
9 Reads

A comparison of pseudo-continuous arterial spin labelling and dynamic susceptibility contrast MRI with and without contrast agent leakage correction in paediatric brain tumours.

Br J Radiol 2019 Feb 3;92(1094):20170872. Epub 2019 Jan 3.

1 Birmingham Children's Hospital , Birmingham , UK.

Objective:: To investigate correlations between MRI perfusion metrics measured by dynamic susceptibility contrast and arterial spin labelling in paediatric brain tumours.

Methods:: 15 paediatric patients with brain tumours were scanned prospectively using pseudo-continuous arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC-) MRI with a pre-bolus to minimise contrast agent leakage. Cerebral blood flow (CBF) maps were produced using ASL. Read More

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http://dx.doi.org/10.1259/bjr.20170872DOI Listing
February 2019
5 Reads

Endoscopic transnasal resection of optic pathway pilocytic astrocytoma.

Childs Nerv Syst 2019 Jan 18;35(1):73-81. Epub 2018 Oct 18.

Department of Neurosurgery, King Saud University, Riyadh, Saudi Arabia.

Purpose: Optic pathway gliomas (OPGs) are low-grade neoplasms that primarily affect children. The management of OPGs remains controversial. Reports on the use of the endoscopic endonasal approach (EEA) in OPGs are extremely limited, and no such reports exist on its utility for pediatric OPGs. Read More

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http://link.springer.com/10.1007/s00381-018-3994-4
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http://dx.doi.org/10.1007/s00381-018-3994-4DOI Listing
January 2019
17 Reads
1.163 Impact Factor

Subcortical Calculation Mapping During Parietal Glioma Surgery in the Dominant Hemisphere: A Case Report.

World Neurosurg 2019 Jan 13;121:205-210. Epub 2018 Oct 13.

Department of Neurosurgery, Nara Medical University, Kashihara, Japan.

Background: To avoid permanent neurologic deficits and preserve brain function in and near the eloquent area, intraoperative electrical stimulation mapping (IESM) is necessary. However, little is known about how these subcortical regions are involved in calculation processing function in patients with glioma.

Case Description: We report the case of a 56-year-old, right-handed woman working at a primary school as a teacher who had recurrent left parietal glioma. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.046DOI Listing
January 2019
5 Reads

Rare and rarer: co-occurrence of stroke-like migraine attacks after radiation therapy and Charles Bonnet syndromes.

Oxf Med Case Reports 2018 Oct 5;2018(10):omy077. Epub 2018 Oct 5.

Neurology Department, Townsville Hospital and Health Service, Douglas, Queensland, Australia.

A 30-year-old man presented with new onset severe headache and homonymous hemianopia, with a subsequent seizure, on a background of a right parietal astrocytoma resected at age 5 with adjuvant chemotherapy and radiotherapy. Magnetic resonance imaging of the brain revealed post-surgical and radiotherapy changes only and a clinical diagnosis of Stroke-like Migraine Attacks after Radiation Therapy (SMART) syndrome was made. Vision subsequently recovered gradually over a 6-week period, however, during the recovery phase he reported well formed hallucinations in the affected hemi-field consisting of small mammals, particularly possums, which gradually became less distinct as vision recovered; a phenomenon which was felt likely to represent the Charles Bonnet syndrome. Read More

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http://dx.doi.org/10.1093/omcr/omy077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172599PMC
October 2018
3 Reads

Comparison of Survival Outcomes Between Partial Resection and Biopsy for Primary Glioblastoma: A Propensity Score-Matched Study.

World Neurosurg 2019 Jan 11;121:e858-e866. Epub 2018 Oct 11.

Department of Neurological Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objectives: Gross total resection for glioblastoma (GBM) has been associated with better prognosis. However, it is not always feasible, and the threshold for the extent of resection required for better prognosis has been controversial. Therefore, we compared the survival and clinical outcomes of patients with GBM who had undergone partial resection (PR) or biopsy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183229
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http://dx.doi.org/10.1016/j.wneu.2018.09.237DOI Listing
January 2019
8 Reads
2.420 Impact Factor

Utility of Magnetic Resonance Perfusion Imaging in Quantifying Active Tumor Fraction and Radiation Necrosis in Recurrent Intracranial Tumors.

World Neurosurg 2019 Jan 9;121:e836-e842. Epub 2018 Oct 9.

Department of Neurosurgery, University of Miami, Miami, Florida, USA.

Background: Ancillary criteria to identify tumor recurrence such as the McDonald criteria or Response Assessment in Neuro-Oncology criteria can provide false diagnoses. Magnetic resonance perfusion (MRP) imaging has been proposed to differentiate post-treatment changes from recurrence. We investigated the utility of MRP to quantify the histological fraction of active tumor (AT), treatment-related changes, and radiation necrosis in recurrent post-treatment intracranial tumors. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.233DOI Listing
January 2019
1 Read

Differentiation of Brain Metastases and Gliomas Based on Color Map of Phase Difference Enhanced Imaging.

Front Neurol 2018 21;9:788. Epub 2018 Sep 21.

Department of Diagnostic and Interventional Radiology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Phase difference enhanced imaging (PADRE), a new phase-related MRI technique, can enhance both paramagnetic and diamagnetic substances, and select which phases to be enhanced. Utilizing these characteristics, we developed color map of PADRE (Color PADRE), which enables simultaneous visualization of myelin-rich structures and veins. Our aim was to determine whether Color PADRE is sufficient to delineate the characteristics of non-gadolinium-enhancing T2-hyperintense regions related with metastatic tumors (MTs), diffuse astrocytomas (DAs) and glioblastomas (GBs), and whether it can contribute to the differentiation of MTs from GBs. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00788
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http://dx.doi.org/10.3389/fneur.2018.00788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160550PMC
September 2018
14 Reads

Leptomeningeal dissemination of spinal pilocytic astrocytoma: a rare entity.

BMJ Case Rep 2018 Sep 28;2018. Epub 2018 Sep 28.

Oncology, NHS Lothian, Edinburgh, UK.

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http://dx.doi.org/10.1136/bcr-2018-226955DOI Listing
September 2018
2 Reads

Can Early Postoperative O-(2-Fluoroethyl)-l-Tyrosine Positron Emission Tomography After Resection of Glioblastoma Predict the Location of Later Tumor Recurrence?

World Neurosurg 2019 Jan 27;121:e467-e474. Epub 2018 Sep 27.

Department of Neurosurgery, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Neurosurgery, Universitätsmedizin der Johannes Gutenberg Universität Mainz, Mainz, Germany.

Objective: Glioblastoma inevitably recurs despite aggressive therapy. Therefore, it would be helpful to predict the location of tumor recurrence from postoperative imaging to customize further treatment. O-(2-fluoroethyl)-l-tyrosine (FET) positron emission tomography (PET) might be a helpful technique, because tumor tissue can be differentiated from normal brain tissue with high specificity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183218
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http://dx.doi.org/10.1016/j.wneu.2018.09.139DOI Listing
January 2019
1 Read

Juniperus Communis Extract Exerts Antitumor Effects in Human Glioblastomas Through Blood-Brain Barrier.

Cell Physiol Biochem 2018 27;49(6):2443-2462. Epub 2018 Sep 27.

Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan.

Background/aims: Herbal materials derived from Juniperus communis (JCo) possess anticancer activity. In this study, we evaluated the efficacy of a JCo berry extract in suppressing glioblastoma growth.

Methods: The effects of JCo extract on the viability of normal and glioma cell lines was analyzed using a modified 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Read More

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http://dx.doi.org/10.1159/000493842DOI Listing
October 2018
5 Reads

Interference with NTSR1 Expression Exerts an Anti-Invasion Effect via the Jun/miR-494/SOCS6 Axis of Glioblastoma Cells.

Cell Physiol Biochem 2018 27;49(6):2382-2395. Epub 2018 Sep 27.

Background/aims: Glioblastoma is the most common and aggressive brain tumor and carries a poor prognosis. Previously, we found that neurotensin receptor 1 (NTSR1) contributes to glioma progression, but the underlying mechanisms of NTSR1 in glioblastoma invasion remain to be clarified. The aim of this study was to investigate the molecular mechanisms of NTSR1 in glioblastoma invasion. Read More

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http://dx.doi.org/10.1159/000493838DOI Listing
October 2018
2 Reads

A Very Rare Case of Right Insular Lobe Langerhans Cell Histiocytosis (CD1a) Mimicking Glioblastoma Multiforme in a Young Adult.

World Neurosurg 2019 Jan 24;121:4-11. Epub 2018 Sep 24.

Department of Neurosurgery, University General Hospital of Alicante, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Alicante, Spain.

Background: Langerhans cell histiocytosis (LCH) is a multisystemic dendritic cell proliferation that is relatively uncommon in adults. Central nervous system LCH outside the pituitary gland is even more uncommon.

Case Description: We report the case of a 42-year-old man who had complained of right-side hemicranial pain and left arm minor paresis. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.093DOI Listing
January 2019
10 Reads

Diagnostic utility of restriction spectrum imaging (RSI) in glioblastoma patients after concurrent radiation-temozolomide treatment: A pilot study.

J Clin Neurosci 2018 Dec 22;58:136-141. Epub 2018 Sep 22.

Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Discriminating between tumor recurrence and treatment effects in glioblastoma patients undergoing radiation-temozolomide (RT/TMZ) therapy remains a major clinical challenge. Here, we report a pilot study to determine the utility of restriction spectrum imaging (RSI), an advanced diffusion-weighted MRI (DWI) technique that affords meso-scale resolution of cell density, in this assessment. A retrospective review of 31 patients with glioblastoma treated between 2011 and 2017 who underwent surgical resection or biopsy over radiographic concern for tumor recurrence following RT/TMZ was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868173110
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http://dx.doi.org/10.1016/j.jocn.2018.09.008DOI Listing
December 2018
11 Reads

Tectal glioma as a distinct diagnostic entity: a comprehensive clinical, imaging, histologic and molecular analysis.

Acta Neuropathol Commun 2018 Sep 25;6(1):101. Epub 2018 Sep 25.

Department of Oncology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, MS 260, Memphis, 38105-3678, TN, USA.

Tectal glioma (TG) is a rare low-grade tumor occurring predominantly in the pediatric population. There has been no detailed analysis of molecular alterations in TG. Risk factors associated with inferior outcome and long-term sequelae of TG have not been well-documented. Read More

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http://dx.doi.org/10.1186/s40478-018-0602-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154813PMC
September 2018
2 Reads

Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy.

Eur J Pharm Biopharm 2018 Nov 20;132:168-179. Epub 2018 Sep 20.

Pharmacology & Toxicology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, India. Electronic address:

Glioblastoma multiforme (GBM) is one of the most encountered gliomas of the central nervous system. The chemotherapeutic drugs used in the treatment of GBM suffer from poor blood brain barrier penetration, severe systemic toxicities and lack of specificity towards tumor cells. There is an urgent need to explore novel drug delivery systems specifically designed for targeting GBM. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09396411173087
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http://dx.doi.org/10.1016/j.ejpb.2018.09.012DOI Listing
November 2018
7 Reads

A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma.

J Neuropathol Exp Neurol 2018 Nov;77(11):1039-1054

National Cancer Institute, National Institutes of Health, Comparative Oncology Program, Center for Cancer Research, Bethesda, Maryland.

The National Cancer Institute-led multidisciplinary Comparative Brain Tumor Consortium (CBTC) convened a glioma pathology board, comprising both veterinarian and physician neuropathologists, and conducted a comprehensive review of 193 cases of canine glioma. The immediate goal was to improve existing glioma classification methods through creation of a histologic atlas of features, thus yielding greater harmonization of phenotypic characterization. The long-term goal was to support future incorporation of clinical outcomes and genomic data into proposed simplified diagnostic schema, so as to further bridge the worlds of veterinary and physician neuropathology and strengthen validity of the dog as a naturally occurring, translationally relevant animal model of human glioma. Read More

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http://dx.doi.org/10.1093/jnen/nly085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181180PMC
November 2018
11 Reads

Radiomics features to distinguish glioblastoma from primary central nervous system lymphoma on multi-parametric MRI.

Neuroradiology 2018 Dec 19;60(12):1297-1305. Epub 2018 Sep 19.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Purpose: To determine the feasibility of using high dimensional computer-extracted features, known as radiomics features, in differentiating primary central nervous system lymphoma (PCNSL) from glioblastoma on multi-parametric MR imaging including diffusion-weighted imaging.

Methods: Retrospective evaluation of data was approved by the local ethics committee and informed consent was waived. A total of 143 patients (two independent cohorts for discovery [n = 86; glioblastoma = 49, PCNSL = 37] and validation [n = 57; glioblastoma = 29, PCNSL = 28]) with newly diagnosed glioblastoma and PCNSL were subjected to radiomics analysis using the multi-parametric MRI (contrast-enhanced T1-weighted imaging, T2-weighted imaging, and diffusion-weighted imaging). Read More

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http://dx.doi.org/10.1007/s00234-018-2091-4DOI Listing
December 2018
2 Reads

Volumetric voxelwise apparent diffusion coefficient histogram analysis for differentiation of the fourth ventricular tumors.

Neuroradiol J 2018 Dec 19;31(6):554-564. Epub 2018 Sep 19.

1 Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, USA.

Purpose: We applied voxelwise apparent diffusion coefficient (ADC) histogram analysis in addition to structural magnetic resonance imaging (MRI) findings and patients' age for differentiation of intraaxial posterior fossa tumors involving the fourth ventricle.

Participants And Methods: Pretreatment MRIs of 74 patients with intraaxial brain neoplasm involving the fourth ventricle, from January 1, 2004 to December 31, 2015, were reviewed. The tumor solid components were segmented and voxelwise ADC histogram variables were determined. Read More

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http://dx.doi.org/10.1177/1971400918800803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243467PMC
December 2018
8 Reads

Findings of DTI-p maps in comparison with T/T-FLAIR to assess postoperative hyper-signal abnormal regions in patients with glioblastoma.

Cancer Imaging 2018 Sep 18;18(1):33. Epub 2018 Sep 18.

Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Institute for Advanced Medical Imaging, Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: The aim of this study was to compare diffusion tensor imaging (DTI) isotropic map (p-map) with current radiographically (T/T-FLAIR) methods based on abnormal hyper-signal size and location of glioblastoma tumor using a semi-automatic approach.

Materials And Methods: Twenty-five patients with biopsy-proved diagnosis of glioblastoma participated in this study. T, T-FLAIR images and diffusion tensor imaging (DTI) were acquired 1 week before radiotherapy. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40644-018-0166-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145209PMC
September 2018
4 Reads
1.286 Impact Factor

Live-Cell Imaging Assays to Study Glioblastoma Brain Tumor Stem Cell Migration and Invasion.

J Vis Exp 2018 08 29(138). Epub 2018 Aug 29.

Hotchkiss Brain Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary;

Glioblastoma (GBM) is an aggressive brain tumor that is poorly controlled with the currently available treatment options. Key features of GBMs include rapid proliferation and pervasive invasion into the normal brain. Recurrence is thought to result from the presence of radio- and chemo-resistant brain tumor stem cells (BTSCs) that invade away from the initial cancerous mass and, thus, evade surgical resection. Read More

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http://dx.doi.org/10.3791/58152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231945PMC
August 2018
5 Reads

[BRAF V600E mutation and clinicopathologic characteristics in 250 cases of brain tumors associated with epilepsy].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):664-670

Department of Pathology, Capital Medical University, Beijing 100010, China.

To investigate the clinicopathologic characteristics and BRAF V600E mutation of brain tumors associated with epilepsy. Totally 250 patients with brain tumors associated with epilepsy were included from March 2008 to August 2017 retrospectively at Sanbo Brain Hospital, Capital Medical University.The clinical manifestations, histological features and BRAF V600E mutation results were collected and analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.003DOI Listing
September 2018
6 Reads

Utility of Early Postoperative Magnetic Resonance Imaging After Glioblastoma Resection: Implications on Patient Survival.

World Neurosurg 2018 Dec 12;120:e1171-e1174. Epub 2018 Sep 12.

Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.

Background: The standard of care for glioblastoma is surgical resection followed by combination temozolomide and radiation. Magnetic resonance imaging (MRI) is used preoperatively for tumor resection planning. In some instances, MRI is also obtained postoperatively to assess for any complications and to determine extent of resection. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.09.027DOI Listing
December 2018
10 Reads

Meningioma mimicking an intraparenchymal cystic tumor.

Nagoya J Med Sci 2018 Aug;80(3):431-434

Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan.

Meningiomas rarely exhibit cystic lesions with mural nodules, and may be misdiagnosed as intraparenchymal cystic tumors. We herein present a 64-year-old woman with a cystic lesion and enhancing mural nodule in the left temporal lobe accompanied by peritumoral brain edema. Differential diagnoses included low-grade gliomas, hemangioblastoma, and cystic meningioma. Read More

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http://dx.doi.org/10.18999/nagjms.80.3.431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125649PMC
August 2018
3 Reads

Fluorescein-Guided Surgery for Pediatric Brainstem Gliomas: Preliminary Study and Technical Notes.

J Neurol Surg B Skull Base 2018 Oct 25;79(Suppl 4):S340-S346. Epub 2018 Jun 25.

Department of Neurosurgery, Capital Medical University, Beijing Tiantan Hospital, Beijing, China.

 Brainstem gliomas (BsG) account for 10 to 15% of pediatric brain tumors. Surgery is the preferred treatment for focal and exophytic lesions. Sodium fluorescein has been proven safe and effective in resection of malignant brain tumors. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1660847
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http://dx.doi.org/10.1055/s-0038-1660847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133691PMC
October 2018
17 Reads