7,777 results match your criteria Brain Imaging in Astrocytoma


Usefulness of [C] Methionine PET in the Differentiation of Tumefactive Multiple Sclerosis from High Grade Astrocytoma.

Neurol Med Chir (Tokyo) 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurosurgery, Tokyo Medical and Dental University.

Tumefactive multiple sclerosis (tumefactive MS) is an atypical variant of MS characterized by a large isolated demyelinating lesion. Because tumefactive MS mimics high grade astrocytoma clinically and radiologically, it is difficult to distinguish between the two using only traditional diagnostic modalities, such as routine magnetic resonance imaging. [C] methionine positron emission tomography (MET PET) has been known as a useful diagnostic tool for glioma. Read More

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http://dx.doi.org/10.2176/nmc.oa.2018-0287DOI Listing

A vascular-task response dependency and its application in functional imaging of brain tumors.

J Neurosci Methods 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiology, Weill Cornell Medicine, New York, NY, USA; Functional MRI Laboratory, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Brain Tumor Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA; Department of Neuroscience, Weill-Cornell Graduate School of the Medical Sciences, New York, NY, USA.

Purpose: Preoperative functional MRI (fMRI) is limited by a muted BOLD response caused by abnormal vasoreactivity and resultant neurovascular uncoupling adjacent to malignant brain tumors. We propose to overcome this limitation and more accurately identify eloquent areas adjacent to brain tumors by independently assessing vasoreactivity using breath-holding and incorporating these data into the fMRI analysis.

Methods: Local vasoreactivity using a breath-holding paradigm with the same timing as the functional motor and language tasks was determined in 16 patients (9 glioblastomas, 1 anaplastic astrocytoma, 5 low grade astrocytomas, and 1 metastasis) and 6 healthy control subjects. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01650270193011
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http://dx.doi.org/10.1016/j.jneumeth.2019.04.004DOI Listing
April 2019
3 Reads

Prognostic Value of O-(2-[F]Fluoroethyl)-L-Tyrosine PET/CT in Newly Diagnosed WHO 2016 Grade II and III Glioma.

Mol Imaging Biol 2019 Apr 11. Epub 2019 Apr 11.

Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacher Str. 6, 97080, Wurzburg, Germany.

Purpose: The use of [F]fluoroethyl)-L-tyrosine ([F]FET) positron emission tomography/computed tomography (PET/CT) has proven valuable in brain tumor management. This study aimed to investigate the prognostic value of radiotracer uptake in newly diagnosed grade II or III gliomas according to the current 2016 World Health Organization (WHO) classification.

Procedures: A total of 35 treatment-naive patients (mean age, 48 ± 17 years) with histologically proven WHO grade II or III gliomas as defined by the current 2016 WHO classification were included. Read More

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http://link.springer.com/10.1007/s11307-019-01357-y
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http://dx.doi.org/10.1007/s11307-019-01357-yDOI Listing
April 2019
1 Read

A young man with visual disturbances and a mild headache.

JAAPA 2018 Apr;31(4):1-3

Jerimiah D. Walker is an emergency medicine PA resident at the William Beaumont Army Medical Center in Fort Bliss, Tex. The author has disclosed no potential conflicts of interest, financial or otherwise. The views expressed in this article are those of the author and do not reflect the official policy of William Beaumont Army Medical Center, the Department of the Army, or the US government.

Headaches are common presenting complaints in EDs throughout the United States. Most are benign and should be treated symptomatically. Certain historical risk factors and physical examination findings increase the likelihood of a secondary cause of headache and warrant further investigation with neuroimaging. Read More

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http://dx.doi.org/10.1097/01.JAA.0000531047.74384.8eDOI Listing

Proliferation-dominant high-grade astrocytoma: survival benefit associated with extensive resection of FLAIR abnormality region.

J Neurosurg 2019 Mar 22:1-8. Epub 2019 Mar 22.

1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, and China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders and Beijing Key Laboratory of Brain Tumor, Beijing, China; and.

OBJECTIVEThe aim of this study was to investigate the relationship between extent of resection (EOR) and survival in terms of clinical, molecular, and radiological factors in high-grade astrocytoma (HGA).METHODSClinical and radiological data from 585 cases of molecularly defined HGA were reviewed. In each case, the EOR was evaluated twice: once according to contrast-enhanced T1-weighted images (CE-T1WI) and once according to fluid attenuated inversion recovery (FLAIR) images. Read More

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http://dx.doi.org/10.3171/2018.12.JNS182775DOI Listing
March 2019
1 Read

Gliomatosis Cerebri Among Children and Adolescents: An Individual-Patient Data Meta-analysis of 182 Patients.

J Child Neurol 2019 Mar 19:883073819836551. Epub 2019 Mar 19.

1 Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background:: Gliomatosis cerebri is a rare but fatal widespread infiltrating central nervous system tumor. We aimed to describe diagnostic and prognostic features of gliomatosis cerebri among children and adolescents.

Methods:: We conducted a systematic literature review for published case reports and case series on patients with histologically confirmed gliomatosis cerebri and extracted data on an individual patient level for those aged 0-18 years. Read More

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http://dx.doi.org/10.1177/0883073819836551DOI Listing
March 2019
3 Reads

Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme.

Radiat Oncol 2019 Mar 4;14(1):37. Epub 2019 Mar 4.

Department of Oncology, Radiotherapy and Gynecologic Oncology, Faculty of Health Sciences, Nicolaus Copernicus University Toruń, Bydgoszcz, Poland.

Background: Subventricular zone (SVZ) involvement is associated with a dismal prognosis in patients with glioblastoma multiforme (GBM). Dual-time point (dtp) O-(2-[F]fluoroethyl)-L-tyrosine (FET) PET/CT (PET) may be a time- and cost-effective alternative to dynamic FET PET, but its prognostic value, particularly with respect to SVZ involvement, is unknown.

Methods: Thirty-five patients had two scans 5-15 and 50-60 min after i. Read More

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http://dx.doi.org/10.1186/s13014-019-1241-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398237PMC
March 2019
3 Reads

Regorafenib in patients with recurrent high-grade astrocytoma.

J Cancer Res Clin Oncol 2019 Apr 28;145(4):1037-1042. Epub 2019 Feb 28.

Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, 45147, Essen, Germany.

Purpose: Antiangiogenic treatment approaches have failed to improve outcome in randomized trials of high-grade astrocytoma. One key mechanism of resistance to antiangiogenic treatment may concern the upregulation of alternative pro-angiogenic pathways. Regorafenib is a potent multikinase inhibitor that may alter some of those pathways. Read More

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http://dx.doi.org/10.1007/s00432-019-02868-5DOI Listing
April 2019
3 Reads

Deep Learning-Based Framework for Identification of Glioblastoma Tumor using Hyperspectral Images of Human Brain.

Sensors (Basel) 2019 Feb 22;19(4). Epub 2019 Feb 22.

Department of Bioengineering, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, TX 75080, USA.

The main goal of brain cancer surgery is to perform an accurate resection of the tumor, preserving as much normal brain tissue as possible for the patient. The development of a non-contact and label-free method to provide reliable support for tumor resection in real-time during neurosurgical procedures is a current clinical need. Hyperspectral imaging is a non-contact, non-ionizing, and label-free imaging modality that can assist surgeons during this challenging task without using any contrast agent. Read More

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http://www.mdpi.com/1424-8220/19/4/920
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http://dx.doi.org/10.3390/s19040920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412736PMC
February 2019
3 Reads

Correlation of Ki-67 Index with Volumetric Segmentation and its Value as a Prognostic Marker in Glioblastoma.

World Neurosurg 2019 Feb 18. Epub 2019 Feb 18.

Department of Neurosurgery, University Medicine of Rostock, Rostock, Germany.

Objective: Previous research has shown a strong correlation between the Ki-67 proliferation index and grade of malignancy in astrocytoma. Ki-67 has also shown encouraging results as a prognostic marker for patients' overall survival (OS). We focus on whether the index is linked to the appearance of glioblastoma on pretreatment magnetic resonance imaging (MRI) or to OS. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.006DOI Listing
February 2019

Carbon ion radiotherapy boost in the treatment of glioblastoma: a randomized phase I/III clinical trial.

Cancer Commun (Lond) 2019 02 20;39(1). Epub 2019 Feb 20.

Department of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Pudong, 4365 Kangxin Road, Shanghai, 201321, P. R. China.

Background: Glioblastoma (GBM) is a highly virulent tumor of the central nervous system, with a median survival < 15 months. Clearly, an improvement in treatment outcomes is needed. However, the emergence of these malignancies within the delicate brain parenchyma and their infiltrative growth pattern severely limit the use of aggressive local therapies. Read More

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http://dx.doi.org/10.1186/s40880-019-0351-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383247PMC
February 2019

Detection of occult neoplastic infiltration in the corpus callosum and prediction of overall survival in patients with glioblastoma using diffusion tensor imaging.

Eur J Radiol 2019 Mar 15;112:106-111. Epub 2019 Jan 15.

Department of Radiology, Division of Neuroradiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool, UK.

Objective: Corpus callosum (CC) involvement is a poor prognostic factor in patients with glioblastoma (GBM). The purpose of this study was to determine whether diffusion tensor imaging (DTI) can quantify occult tumor infiltration in the CC and predict the overall survival in GBM patients.

Methods: Forty-eight patients with pathologically proven GBM and 17 normal subjects were included in this retrospective study. Read More

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http://dx.doi.org/10.1016/j.ejrad.2019.01.015DOI Listing
March 2019
1 Read

The benefit of surveillance imaging for paediatric cerebellar pilocytic astrocytoma.

Childs Nerv Syst 2019 May 15;35(5):801-805. Epub 2019 Feb 15.

Department of Paediatric Oncology, Alder Hey Children's Hospital, Eaton Road, Liverpool, L12 2AP, UK.

Objectives: Paediatric cerebellar pilocytic astrocytomas (PA) (WHO grade 1) are amongst the most common of childhood brain tumours and are generally amenable to resection, with surgery alone being curative in the majority of cases. There is, however, a lack of consensus regarding the frequency and duration of post-treatment MRI surveillance for these tumours. This is important, as follow-up imaging is a significant use of resources and often associated with patient and family anxiety. Read More

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http://link.springer.com/10.1007/s00381-019-04078-3
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http://dx.doi.org/10.1007/s00381-019-04078-3DOI Listing
May 2019
9 Reads

Atypical Presentation of Glioblastoma Multiforme.

Eur J Case Rep Intern Med 2018 27;5(9):000954. Epub 2018 Sep 27.

Neurology Department, Henry Ford Health System, Detroit, MI, USA.

Background: Glioblastoma multiforme (GBM) is a highly malignant glial tumour classified by the World Health Organization (WHO) as a stage IV astrocytoma. It varies in shape and size and can be cystic, vascular and necrotic. It often appears as a ring-enhancing lesion on magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.12890/2018_000954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346815PMC
September 2018
3 Reads

Hemorrhagic presentation of frontal partially calcified pilocytic astrocytoma in an 18-year-old woman: A case report and literature review as "clinical case".

Neurochirurgie 2019 Feb 30;65(1):32-35. Epub 2019 Jan 30.

Department of radiology, Assistance publique-Hôpitaux de Paris, Bichat Hospital, 46, rue Henri-Huchard, 75018, Paris, France; INSERM U1148, 75018 Paris, France; University Paris 7, Faculté de Médecine Xavier-Bichat, 75018 Paris, France. Electronic address:

We report an unusual case of a frontal partially calcified pilocytic astrocytoma (PA) (WHO grade 1) in an 18-year-old woman who presented with acute, spontaneous intracerebral hemorrhage. Histopathology revealed the PA was mixed with psammoma bodies and areas of vascular proliferation responsible for a hypervascular pattern. The patient underwent a total gross resection. Read More

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http://dx.doi.org/10.1016/j.neuchi.2018.12.002DOI Listing
February 2019

Outcomes Following Proton Therapy for Pediatric Low-Grade Glioma.

Int J Radiat Oncol Biol Phys 2019 May 23;104(1):149-156. Epub 2019 Jan 23.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida.

Purpose: Dosimetric studies show that proton therapy can reduce the low/intermediate radiation dose to uninvolved tissue in children with low-grade glioma (LGG). For this reason, LGG is the fourth most common pediatric tumor treated with proton therapy, yet clinical outcome data on efficacy and toxicity are limited.

Methods And Materials: We reviewed the medical records of 174 children (≤21 years old) with nonmetastatic LGG enrolled on a prospective protocol and treated with proton therapy between 2007 and 2017. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.01.078DOI Listing
May 2019
26 Reads

Influence of molecular classification in anaplastic glioma for determining outcome and future approach to management.

J Med Imaging Radiat Oncol 2019 Apr 24;63(2):272-280. Epub 2019 Jan 24.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, New South Wales, Australia.

Introduction: Assess survival of patients with anaplastic glioma (AG) and the relationship to molecular subtype.

Methods: Patients with AG managed with IMRT between 2008 and 2014 were entered into a prospective database assessing relapse-free survival (RFS) and overall survival (OS). Isocitrate dehydrogenase (IDH) mutations were assessed prospectively from 2011, and subsequent testing of historical patients allowing categorisation under WHO 2016 classification as anaplastic astrocytoma IDH wild type (AAwt), anaplastic astrocytoma IDH mutated (AAmut), anaplastic oligodendroglioma (AOD) or other glial tumour (OTH). Read More

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http://dx.doi.org/10.1111/1754-9485.12850DOI Listing
April 2019
4 Reads

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
14 Reads

Papillary glioblastoma exhibiting a neuroradiological cyst with a mural nodule: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14102

Division of Human Pathology, Department of Pathology and Microbiology.

Rationale: Glioblastomas are malignant, infiltrating gliomas classified as grade IV by the World Health Organization. Genetically, most glioblastomas do not exhibit the isocitrate dehydrogenase (IDH) 1/2 gene mutation and rarely harbor the 1p/19q co-deletion. Neuroradiologically, glioblastomas rarely form a cyst with a mural nodule lesion. Read More

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http://Insights.ovid.com/crossref?an=00005792-201901110-0007
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http://dx.doi.org/10.1097/MD.0000000000014102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336597PMC
January 2019
3 Reads

Tissue-type mapping of gliomas.

Neuroimage Clin 2019 25;21:101648. Epub 2018 Dec 25.

Neurosciences Research Centre, Molecular and Clinical Sciences Research Institute, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK. Electronic address:

Purpose: To develop a statistical method of combining multimodal MRI (mMRI) of adult glial brain tumours to generate tissue heterogeneity maps that indicate tumour grade and infiltration margins.

Materials And Methods: We performed a retrospective analysis of mMRI from patients with histological diagnosis of glioma (n = 25). H Magnetic Resonance Spectroscopic Imaging (MRSI) was used to label regions of "pure" low- or high-grade tumour across image types. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.101648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411966PMC
December 2018
2 Reads

The role of diffusion and perfusion magnetic resonance imaging in differentiation of haemangioblastomas and pilocytic astrocytomas.

Pol J Radiol 2018 10;83:e197-e203. Epub 2018 May 10.

Department of General and Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.

Purpose: Haemangioblastomas (HABLs) and pilocytic astrocytomas (PAs) are brain tumours presenting similar appearance and location in conventional magnetic resonance (MR) imaging. The purpose of our study was to determine whether a detailed analysis of diffusion (DWI) and perfusion (PWI) characteristics can be useful in preoperative differentiation of these tumours.

Material And Methods: The study group consisted of biopsy proven six HABLs and six PAs, which underwent preoperative standard MR examinations including PWI and DWI. Read More

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https://www.termedia.pl/doi/10.5114/pjr.2018.75870
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http://dx.doi.org/10.5114/pjr.2018.75870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323599PMC
May 2018
7 Reads

Ganglioglioma Arising from the Septum Pellucidum: Case Report and Review of the Literature.

Pediatr Neurosurg 2019 8;54(1):36-45. Epub 2019 Jan 8.

Department of Neurological Surgery, University of Virginia Health Science Center, University of Virginia, Charlottesville, Virginia, USA,

Background: Gangliogliomas are low-grade neoplasms that typically affect patients under the age of 30 and present with epilepsy and symptoms of mass effect. Here, we report a case of an intraventricular ganglioglioma involving the septum pellucidum in a pediatric patient with history of optic glioma. Only one other pediatric intraventricular ganglioglioma arising from the septum pellucidum has been reported previously. Read More

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https://www.karger.com/Article/FullText/495043
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http://dx.doi.org/10.1159/000495043DOI Listing
January 2019
18 Reads
0.497 Impact Factor

Conventionally fractionated stereotactic radiotherapy (CFRT) in combination with dose-dense temozolomide (TMZ) in relapsed malignant glioma: A case report.

Medicine (Baltimore) 2019 Jan;98(1):e13869

Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei, P.R. China.

Rationale: At present, there is no uniform consensus on the treatment of recurrent glioblastoma, especially the re-irradiation dose and temozolomide (TMZ) dose. The literature on the treatment of recurrent glioblastoma (GBM) by conventionally fractionated stereotactic radiotherapy (CFRT) is even rarer.

Patient Concerns: A 44-year-old woman was admitted to our hospital for residual tumor after reoperation. Read More

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http://dx.doi.org/10.1097/MD.0000000000013869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344191PMC
January 2019
3 Reads

Repeat Bleeding 18 Years After Hemorrhagic Pilocytic Astrocytoma: Prognostic Implications of Conservative Management-Case Report and Literature Review.

World Neurosurg 2019 Mar 19;123:328-338. Epub 2018 Dec 19.

Department of Neurosurgery, Policlinico "Tor Vergata", University of Rome "Tor Vergata", Rome, Italy.

Background: Acute hemorrhagic occurrence of pilocytic astrocytomas is extremely rare but has become increasingly recognized and often presents in clinically emergent situations. The precise significance of hemorrhage in these tumors and its pathogenetic mechanisms have not yet been defined. Nothing is known about the natural history of bleeding pilocytic astrocytomas. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183285
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http://dx.doi.org/10.1016/j.wneu.2018.12.032DOI Listing
March 2019
8 Reads

Brainstem astrocytoma as a neuro-Behçet's disease mimic.

BMJ Case Rep 2018 Dec 7;11(1). Epub 2018 Dec 7.

Internal Medicine, Division of Rheumatology, New York University, New York City, New York, USA.

A 58-year-old man with a history of recurrent aphthous ulcers since childhood was admitted to the hospital with acute neurological decline characterised by loss of motor dexterity, dysarthria, dysphagia and unsteady gait. MRI brain was significant for symmetrical hyperintense T2 fluid attenuated inversion recovery (FLAIR) in the corticospinal tracts, including parts of the pons and the mesodiencephalic junction. Though initial concern was for neuro-Behçet's disease, brain biopsy ultimately revealed a diagnosis of astrocytoma. Read More

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http://dx.doi.org/10.1136/bcr-2018-226945DOI Listing
December 2018

Magnetic resonance imaging-guided radiation therapy using animal models of glioblastoma.

Br J Radiol 2019 Mar 17;92(1095):20180713. Epub 2019 Jan 17.

2 Department of Nuclear Medicine, Ghent University Hospital , Ghent , Belgium.

Glioblastoma is the most aggressive and most common malignant primary brain tumour in adults and has a high mortality and morbidity. Because local tumour control in glioblastoma patients is still elusive in the majority of patients, there is an urgent need for alternative treatment strategies. However, to implement changes to the existing clinical standard of care, research must be conducted to develop alternative treatment strategies. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180713
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http://dx.doi.org/10.1259/bjr.20180713DOI Listing
March 2019
11 Reads

Comparisons Between PET With 11C-Methyl-L-Methionine and Arterial Spin Labeling Perfusion Imaging in Recurrent Glioblastomas Treated With Bevacizumab.

Clin Nucl Med 2019 Mar;44(3):186-193

From the Department of Neurosurgery.

Purpose: The aim of this study was to clarify whether arterial spin labeling (ASL) perfusion imaging can assess biological effects from bevacizumab (BEV) therapy as reliably as PET with C-methyl-L-methionine (C-met-PET).

Materials And Methods: Twenty-four patients with recurrent glioblastoma were examined using both ASL and C-met-PET before and 4 and 8 weeks after starting BEV treatment. Tumor-to-normal brain (T/N) ratios, fluctuations in T/N ratio, and tumor volumes were compared between ASL and C-met-PET. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002417DOI Listing
March 2019
1 Read

Intraventricular Pilocytic Astrocytoma With KIAA1549/BRAF Fusion Arising in a 44-Year Old.

J Neuropathol Exp Neurol 2019 Feb;78(2):187-190

Department of Pathology, Duke University, Durham, North Carolina.

Rare pilocytic astrocytomas (PA) have been described to arise in the ventricles of children. They are even less common in this location for the adult population. We present the case of a 44-year old man presenting with vision and mental status changes. Read More

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http://dx.doi.org/10.1093/jnen/nly116DOI Listing
February 2019
3 Reads

Radiographic assessment of contrast enhancement and T2/FLAIR mismatch sign in lower grade gliomas: correlation with molecular groups.

J Neurooncol 2019 Jan 7;141(2):327-335. Epub 2018 Dec 7.

Translational Neuro-Oncology Laboratory, Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.

Purpose: With the updated World Health Organization (WHO) 2016 neuropathological diagnostic criteria, radiographic prognostic associations in lower-grade gliomas (LGG, WHO grade II and III) are undergoing re-evaluation.

Methods: We identified 316 LGG patients (151 grade II and 165 grade III) for a combined cohort from three independent databases. We analyzed the preoperative axial FLAIR, axial T2-weighted and post-gadolinium volumetric T1-weighted MR images. Read More

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http://dx.doi.org/10.1007/s11060-018-03034-6DOI Listing
January 2019
1 Read

Opening the Blood-Brain Barrier and Improving the Efficacy of Temozolomide Treatments of Glioblastoma Using Pulsed, Focused Ultrasound with a Microbubble Contrast Agent.

Biomed Res Int 2018 11;2018:6501508. Epub 2018 Nov 11.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Objective: To explore the effects of pulsed, focused, and microbubble contrast agent-enhanced ultrasonography (mCEUS) on blood-brain barrier (BBB) permeability and the efficacy temozolomide for glioblastoma.

Methods: Wistar rats (n = 30) were divided into three groups (n = 10 per group) to determine optimal CUES conditions for achieving BBB permeability, as assessed by ultrastructure transmission electron microscopy (TEM) and western blot assays for the tight junction protein claudin-5. Optimized mCEUS effects on BBB permeability were subsequently confirmed with Evans blue staining (2 groups of 10 rats). Read More

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http://dx.doi.org/10.1155/2018/6501508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252217PMC
March 2019
1 Read

Grading and proliferation assessment of diffuse astrocytic tumors with monoexponential, biexponential, and stretched-exponential diffusion-weighted imaging and diffusion kurtosis imaging.

Eur J Radiol 2018 Dec 5;109:188-195. Epub 2018 Nov 5.

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Purpose: To compare the main parameters derived from monoexponential, biexponential and stretched-exponential diffusion-weighted imaging (DWI) and diffusion kurtosis imaging (DKI) with respect to diagnostic performance for tumor grading and proliferation assessment in diffuse astrocytic tumors (DATs).

Materials And Methods: Fifty-eight pathologically confirmed DAT patients who underwent DWI and DKI on a 3-T scanner were prospectively collected and retrospectively reviewed. Measurements including the apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D), perfusion fraction (f), distributed diffusion coefficient (DDC), heterogeneity index (α), mean diffusivity (MD), fractional anisotropy (FA), and mean kurtosis (MK) were compared between tumor grades (Ⅱ, Ⅲ, and Ⅳ) by using a Jonckheere-Terpstra test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0720048X183039
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http://dx.doi.org/10.1016/j.ejrad.2018.11.003DOI Listing
December 2018
13 Reads

Diffusion Kurtosis Imaging Reflects Glial Fibrillary Acidic Protein (GFAP), Topo IIα, and O⁶-Methylguanine-DNA Methyltransferase (MGMT) Expression in Astrocytomas.

Med Sci Monit 2018 Dec 6;24:8822-8830. Epub 2018 Dec 6.

Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China (mainland).

BACKGROUND Astrocytomas are the most common primary brain neoplasms. Biological indicators of astrocytomas can reflect its biological characteristics. The aim of this study was to assess the expression of the pathological glial fibrillary acidic protein (GFAP) Topo IIα and O⁶-methylguanine-DNA methyltransferase (MGMT) in astrocytomas using magnetic resonance (MR) diffusion kurtosis imaging (DKI) to evaluate the biological characteristics of astrocytomas. Read More

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https://www.medscimonit.com/abstract/index/idArt/911631
Publisher Site
http://dx.doi.org/10.12659/MSM.911631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292149PMC
December 2018
10 Reads

Differentiation of Primary Central Nervous System Lymphoma From Glioblastoma: Quantitative Analysis Using Arterial Spin Labeling and Diffusion Tensor Imaging.

World Neurosurg 2019 Mar 29;123:e303-e309. Epub 2018 Nov 29.

Department of Diagnostic Radiology, Kafr Elsheak Faculty of Medicine, Kafr Elsheak, Egypt.

Objective: Differentiation of primary central nervous system lymphoma (PCNSL) from glioblastoma using arterial spin labeling perfusion and diffusion tensor imaging (DTI).

Methods: We performed a prospective study of 31 patients with a provisional diagnosis of PCNSL and glioblastoma who underwent conventional magnetic resonance imaging, DTI, and arterial spin labeling of the brain. The tumor blood flow (TBF), mean diffusivity (MD) plus fractional anisotropy (FA) of the mass were measured. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183271
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http://dx.doi.org/10.1016/j.wneu.2018.11.155DOI Listing
March 2019
5 Reads
2.417 Impact Factor

Awake Transcortical Approach Resection of Dominant Posterior Cingulate Gyrus Glioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Two techniques, the translongitudinal cerebral fissure and transfrontal cortical approach, can be employed to resect posterior cingulate gyrus tumors. We demonstrate the transcortical technique comprising of multimodal imaging guidance and awake brain mapping which enabled maximum safe resection of dominant cingulate gyrus glioma. The patient, a 49-yr-old female, came to clinic after experiencing headache for a month. Read More

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https://academic.oup.com/ons/advance-article/doi/10.1093/ons
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http://dx.doi.org/10.1093/ons/opy347DOI Listing
November 2018
17 Reads

Impact of subventricular zone irradiation on outcome of patients with glioblastoma.

J Cancer Res Ther 2018 Oct-Dec;14(6):1202-1206

Department of Radiation Physics, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Purpose: Glioblastoma (GBM) is characterized by early relapse and mortality. Treatment resistance could be a characteristic exhibited by pro-genitor neoplastic cells that reside in the subventricular zone (SVZ). This retrospective study was conducted to assess the correlation of SVZ doses and survival in patients with GBM. Read More

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http://www.cancerjournal.net/preprintarticle.asp?id=228996
Publisher Site
http://dx.doi.org/10.4103/jcrt.JCRT_295_17DOI Listing
February 2019
7 Reads

COMBImage: a modular parallel processing framework for pairwise drug combination analysis that quantifies temporal changes in label-free video microscopy movies.

BMC Bioinformatics 2018 Nov 26;19(1):453. Epub 2018 Nov 26.

Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University, Uppsala, Sweden.

Background: Large-scale pairwise drug combination analysis has lately gained momentum in drug discovery and development projects, mainly due to the employment of advanced experimental-computational pipelines. This is fortunate as drug combinations are often required for successful treatment of complex diseases. Furthermore, most new drugs cannot totally replace the current standard-of-care medication, but rather have to enter clinical use as add-on treatment. Read More

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https://bmcbioinformatics.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/s12859-018-2458-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257977PMC
November 2018
19 Reads

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.

Nat Commun 2018 11 21;9(1):4904. Epub 2018 Nov 21.

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.

Therapeutic options for the treatment of glioblastoma remain inadequate despite concerted research efforts in drug development. Therapeutic failure can result from poor permeability of the blood-brain barrier, heterogeneous drug distribution, and development of resistance. Elucidation of relationships among such parameters could enable the development of predictive models of drug response in patients and inform drug development. Read More

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http://dx.doi.org/10.1038/s41467-018-07334-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249307PMC
November 2018
9 Reads

Transcriptome profiling reveals PDZ binding kinase as a novel biomarker in peritumoral brain zone of glioblastoma.

J Neurooncol 2019 Jan 20;141(2):315-325. Epub 2018 Nov 20.

Department of Neuropathology, National Institute of Mental Health and Neuroscience, Bangalore, India.

Purpose: Peritumoural brain zone (PT) of glioblastoma (GBM) is the area where tumour recurrence is often observed. We aimed to identify differentially regulated genes between tumour core (TC) and PT to understand the underlying molecular characteristics of infiltrating tumour cells in PT.

Methods: 17 each histologically characterised TC and PT tissues of GBM along with eight control tissues were subjected to cDNA Microarray. Read More

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http://dx.doi.org/10.1007/s11060-018-03051-5DOI Listing
January 2019
17 Reads

Pilocytic Astrocytoma with Gangliocytic Differentiation to Pilomyxoid Astrocytoma-expanding the Morphological Spectrum: Case Report and Literature Review.

Asian J Neurosurg 2018 Oct-Dec;13(4):1193-1196

Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

We present a rare case of pilocytic astrocytoma (PA) with gangliocytic differentiation arising in the suprasellar/chiasmatic region in a young boy that showed a rapid regrowth after the 1 subtotal resection and "differentiated" into pilomyxoid astrocytoma (PMA) in subsequent recurrences. The clinical course, imaging, and histological features have been described with a review of the literature. While PA is well-circumscribed, biphasic tumors with bipolar piloid cells, those arising in the diencephalic region often contain myxoid stroma, angiocentric pattern, and "intermediate" features between PA and PMA. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_247_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208220PMC
November 2018
19 Reads

A malignant astrocytoma with uncommon angiocentric features and dot-like EMA expression.

Contemp Oncol (Pozn) 2018 30;22(3):205-208. Epub 2018 Sep 30.

Department of Pathology, Chair of Oncology, Medical University of Lodz, Poland.

Angiocentric features are uncommon in high-grade World Health Organisation (WHO) brain tumours, whilst they are typical for WHO grade I tumours, e.g. angiocentric gliomas. Read More

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https://www.termedia.pl/doi/10.5114/wo.2018.78944
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http://dx.doi.org/10.5114/wo.2018.78944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238096PMC
September 2018
14 Reads

Overall survival prediction in glioblastoma multiforme patients from volumetric, shape and texture features using machine learning.

Surg Oncol 2018 Dec 10;27(4):709-714. Epub 2018 Sep 10.

National University of Singapore, Singapore. Electronic address:

Glioblastoma multiforme (GBM) are aggressive brain tumors, which lead to poor overall survival (OS) of patients. OS prediction of GBM patients provides useful information for surgical and treatment planning. Radiomics research attempts at predicting disease prognosis, thus providing beneficial information for personalized treatment from a variety of imaging features extracted from multiple MR images. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.09.002DOI Listing
December 2018

Tumour volume reduction following PET guided intensity modulated radiation therapy and temozolomide in IDH mutated anaplastic glioma.

J Clin Neurosci 2019 Jan 14;59:68-74. Epub 2018 Nov 14.

Northern Sydney Cancer Centre, Royal North Shore Hospital, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Sydney NeuroOncology Group, Sydney, Australia.

The role of maximal surgical debulking in isocitrate dehydrogenase (IDH) mutated anaplastic glioma prior to adjuvant radiation therapy remains uncertain. This study assessed the reduction in tumour volume following intensity modulated radiation therapy (IMRT) and temozolomide in this favourable and more responsive tumour pathology. 56 patients were managed from 2011 to 2014 and 53 had residual disease. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.11.005DOI Listing
January 2019
4 Reads

Long-term Seizure Disorder Caused by a Dermoid Cyst with Catastrophic Developments.

Cureus 2018 Sep 10;10(9):e3272. Epub 2018 Sep 10.

Surgery/Neurosurgery, University of Toledo Medical Center, Toledo, USA.

Glioblastoma multiforme (GBM) is a World Health Organization (WHO) grade IV primary malignant astrocytoma. Aneurysms are devastating intracranial neurovascular pathologies. Intracranial dermoid cysts are common, benign lesions which can be clinically silent or associated with seizure disorder. Read More

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https://www.cureus.com/articles/12761-long-term-seizure-diso
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http://dx.doi.org/10.7759/cureus.3272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235633PMC
September 2018
21 Reads

Proliferative Index in Pediatric Pilocytic Astrocytoma by Region of Origin and Prediction of Clinical Behavior.

Pediatr Neurosurg 2018 14;53(6):395-400. Epub 2018 Nov 14.

Children's Hospital LA, Los Angeles, California, USA.

Background/aims: Pilocytic astrocytomas are common pediatric tumors. Molecular profiles vary with location of origin. Comparisons of proliferation have not been reported. Read More

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http://dx.doi.org/10.1159/000490466DOI Listing
January 2019
11 Reads

Nanotechnology for Treatment of Glioblastoma Multiforme.

J Transl Int Med 2018 Sep 9;6(3):128-133. Epub 2018 Oct 9.

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Glioblastoma multiforme (GBM), a grade IV astrocytoma as defined by the World Health Organization (WHO) criteria, is the most common primary central nervous system tumor in adults. After treatment with the current standard of care consisting of surgical resection, concurrent temozolomide (TMZ), and radiation, the median survival is only 15 months. The limited and less-effective treatment options for these highly aggressive GBMs call for the development of new techniques and the improvement of existing technologies. Read More

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https://content.sciendo.com/view/journals/jtim/6/3/article-p
Publisher Site
http://dx.doi.org/10.2478/jtim-2018-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231306PMC
September 2018
10 Reads

Differentiation between pilocytic astrocytoma and glioblastoma: a decision tree model using contrast-enhanced magnetic resonance imaging-derived quantitative radiomic features.

Eur Radiol 2018 Nov 12. Epub 2018 Nov 12.

Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, China.

Objective: To differentiate brain pilocytic astrocytoma (PA) from glioblastoma (GBM) using contrast-enhanced magnetic resonance imaging (MRI) quantitative radiomic features by a decision tree model.

Methods: Sixty-six patients from two centres (PA, n = 31; GBM, n = 35) were randomly divided into training and validation data sets (about 2:1). Quantitative radiomic features of the tumours were extracted from contrast-enhanced MR images. Read More

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http://link.springer.com/10.1007/s00330-018-5706-6
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http://dx.doi.org/10.1007/s00330-018-5706-6DOI Listing
November 2018
17 Reads
4.014 Impact Factor

Fully Automatic Brain Tumor Segmentation using End-To-End Incremental Deep Neural Networks in MRI images.

Comput Methods Programs Biomed 2018 Nov 21;166:39-49. Epub 2018 Sep 21.

Gaspard Monge Computer Science Laboratory, ESIEE-Paris, University Paris-Est Marne-la-Vallée, France. Electronic address:

Background And Objective: Nowadays, getting an efficient Brain Tumor Segmentation in Multi-Sequence MR images as soon as possible, gives an early clinical diagnosis, treatment and follow-up. The aim of this study is to develop a new deep learning model for the segmentation of brain tumors. The proposed models are used to segment the brain tumors of Glioblastomas (with both high and low grade). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01692607183090
Publisher Site
http://dx.doi.org/10.1016/j.cmpb.2018.09.007DOI Listing
November 2018
24 Reads

Imaging tryptophan uptake with positron emission tomography in glioblastoma patients treated with indoximod.

J Neurooncol 2019 Jan 10;141(1):111-120. Epub 2018 Nov 10.

Department of Neurosurgery, Northwestern University, Chicago, USA.

Introduction: Glioblastoma (GBM) is the most frequent and aggressive primary tumor of the central nervous system, accounting for over 50% of all primary malignant gliomas arising in the adult brain. Even after surgical resection, adjuvant radiotherapy (RT) and temozolomide (TMZ) chemotherapy, as well as tumor-treating fields, the median survival is only 15-20 months. We have identified a pathogenic mechanism that contributes to the tumor-induced immunosuppression in the form of increased indoleamine 2,3 dioxygenase 1 (IDO1) expression; an enzyme that metabolizes the essential amino acid, tryptophan (Trp), into kynurenine (Kyn). Read More

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http://link.springer.com/10.1007/s11060-018-03013-x
Publisher Site
http://dx.doi.org/10.1007/s11060-018-03013-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414051PMC
January 2019
11 Reads

Incidence of initial spinal metastasis in glioblastoma patients and the importance of spinal screening using MRI.

J Neurooncol 2019 Jan 9;141(2):337-345. Epub 2018 Nov 9.

Department of Neurosurgery, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

Purpose: Intracranial glioblastomas with simultaneous spinal lesions prior to chemoradiation therapy or craniotomy, defined as initial spinal metastasis, are not well understood. Herein, we investigated intracranial glioblastoma and demonstrated the importance of spinal screening using gadolinium enhanced spinal magnetic resonance imaging (Gd-MRI).

Methods: Consecutive adult patients with intracranial glioblastoma were treated between 2010 and 2014 and received spinal screening using Gd-MRI. Read More

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http://dx.doi.org/10.1007/s11060-018-03036-4DOI Listing
January 2019

The consistency of neuropathological diagnoses in patients undergoing surgery for suspected recurrence of glioblastoma.

J Neurooncol 2019 Jan 9;141(2):347-354. Epub 2018 Nov 9.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: Clinical factors and neuro-imaging in patients with glioblastoma who appear to progress following standard chemoradiation are unable to reliably distinguish tumor progression from pseudo-progression. As a result, surgery is commonly recommended to establish a final diagnosis. However, studies evaluating the pathologists' agreement on pathologic diagnoses in this setting have not been previously evaluated. Read More

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http://link.springer.com/10.1007/s11060-018-03037-3
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http://dx.doi.org/10.1007/s11060-018-03037-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342857PMC
January 2019
13 Reads