640 results match your criteria Brain Contusion Imaging


MR Imaging for Assessing Injury Severity and Prognosis in Acute Traumatic Spinal Cord Injury.

Radiol Clin North Am 2019 Mar 17;57(2):319-339. Epub 2018 Nov 17.

Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143, USA; Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA.

T2-weighted (T2W) imaging is the most important sequence for detection of acute traumatic spinal cord pathology in clinical practice. Intramedullary hemorrhage on T2W imaging is associated with some component of irreversible injury and arguably the most robust MR imaging predictor of injury severity. The MR imaging appearance of the injured spinal cord in the early stages of injury is highly dynamic, and the time delay from injury to imaging must be considered in image interpretation. Read More

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http://dx.doi.org/10.1016/j.rcl.2018.09.004DOI Listing

Positive allosteric modulation of cholinergic receptors improves spatial learning following cortical contusion injury in mice.

J Neurotrauma 2019 Jan 28. Epub 2019 Jan 28.

Veterans Affairs Greater Los Angeles Healthcare System, Research , 11301 Wilshire Blvd , Bldg 115 Room 319 , Los Angeles, California, United States , 90073 ;

We examined benzyl quinolone carboxylic acid (BQCA), a novel M1 muscarinic positive allosteric modulator, for improving memory and motor dysfunction following cerebral cortical contusion injury (CCI). Adult mice received unilateral motorsensory cortical CCI or sham injury. BQCA (5, 10, 20mg/kg, i. Read More

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http://dx.doi.org/10.1089/neu.2018.6036DOI Listing
January 2019
1 Read

Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits.

Int J Mol Sci 2018 Nov 26;19(12). Epub 2018 Nov 26.

Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA 94143, USA.

Traumatic brain injury (TBI) is of particular concern for the aging community since there is both increased incidence of TBI and decreased functional recovery in this population. In addition, TBI is the strongest environmental risk factor for development of Alzheimer's disease and other dementia-related neurodegenerative disorders. Critical changes that affect cognition take place over time following the initial insult. Read More

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http://www.mdpi.com/1422-0067/19/12/3753
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http://dx.doi.org/10.3390/ijms19123753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321529PMC
November 2018
1 Read

Clinical Profile and Autopsy Findings in Fatal Head Injuries.

J Emerg Trauma Shock 2018 Jul-Sep;11(3):205-210

Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, (JIPMER), Puducherry, India.

Aims: This study aims to correlate the autopsy findings with the clinical picture and imaging report in fatal head injury patients.

Settings And Design: A descriptive study conducted at tertiary care hospital in South India from July 2015 to December 2016.

Patients And Methods: All patients with head injuries who were admitted to our Emergency and Trauma Centre and underwent autopsy were included in the study. Read More

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http://dx.doi.org/10.4103/JETS.JETS_127_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182969PMC
November 2018
9 Reads

Fetal closed head injuries following maternal motor vehicle accident: A clinicopathologic case report.

Medicine (Baltimore) 2018 Nov;97(44):e13133

Department of Pediatrics.

Rationale: The clinicopathologic appearance of fetal closed head injury (FCHI) due to a maternal motor vehicle accident has not been fully investigated because of its extreme rarity.

Patients Concern: A 22-year-old woman at 31 weeks of gestation was riding in the front passenger seat of a car, and another rightward-turning car struck the right side of her vehicle.

Diagnosis: Uterine injury with placental abruption was strongly suspected. Read More

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http://dx.doi.org/10.1097/MD.0000000000013133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221710PMC
November 2018
2 Reads

Changes in Posttraumatic Brain Edema in Craniectomy-Selective Brain Hypothermia Model Are Associated With Modulation of Aquaporin-4 Level.

Front Neurol 2018 2;9:799. Epub 2018 Oct 2.

Department of Neurosurgery, Faculty of Medicine, Saarland University Medical Center, Saarland University, Homburg, Germany.

Both hypothermia and decompressive craniectomy have been considered as a treatment for traumatic brain injury. In previous experiments we established a murine model of decompressive craniectomy and we presented attenuated edema formation due to focal brain cooling. Since edema development is regulated via function of water channel proteins, our hypothesis was that the effects of decompressive craniectomy and of hypothermia are associated with a change in aquaporin-4 (AQP4) concentration. Read More

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http://dx.doi.org/10.3389/fneur.2018.00799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176780PMC
October 2018
1 Read

Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research.

J Neurotrauma 2018 Dec 11. Epub 2018 Dec 11.

1 Department of Radiology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium.

Observer variability in local radiological reading is a major concern in large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of this study is to compare central with local reading of TBI imaging datasets and to investigate the added value of central review. Read More

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http://dx.doi.org/10.1089/neu.2018.6061DOI Listing
December 2018
1 Read

Angiopoietin/Tie2 Axis Regulates the Age-at-Injury Cerebrovascular Response to Traumatic Brain Injury.

J Neurosci 2018 Nov 21;38(45):9618-9634. Epub 2018 Sep 21.

The Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine,

Although age-at-injury influences chronic recovery from traumatic brain injury (TBI), the differential effects of age on early outcome remain understudied. Using a male murine model of moderate contusion injury, we investigated the underlying mechanism(s) regulating the distinct response between juvenile and adult TBI. We demonstrate similar biomechanical and physical properties of naive juvenile and adult brains. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0914-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222064PMC
November 2018
1 Read

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury.

Proc Natl Acad Sci U S A 2018 09 10;115(39):E9230-E9238. Epub 2018 Sep 10.

Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA 15213;

Recombinant tissue plasminogen activator (tPA) is a Food and Drug Administration-approved thrombolytic treatment for ischemic stroke. tPA is also naturally expressed in glial and neuronal cells of the brain, where it promotes axon outgrowth and synaptic plasticity. However, there are conflicting reports of harmful versus neuroprotective effects of tPA in acute brain injury models. Read More

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http://dx.doi.org/10.1073/pnas.1810693115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166834PMC
September 2018
3 Reads

Increases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation After Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain.

Adv Exp Med Biol 2018 ;1072:27-31

Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Traumatic brain injury (TBI), causing neurological deficit in 70% of survivors, still lacks a clinically proven effective therapy. Transcranial direct current stimulation (tDCS) has emerged as a promising electroceutical therapeutic intervention possibly suitable for TBI; however, due to limited animal studies the mechanisms and optimal parameters are unknown. Using a mouse model of TBI we evaluated the acute effects of the anodal tDCS on cerebral blood flow (CBF) and tissue oxygenation, and assessed its efficacy in long-term neurologic recovery. Read More

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http://dx.doi.org/10.1007/978-3-319-91287-5_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294145PMC
January 2019
13 Reads

Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: a TRACK-TBI study.

Neurol Res 2018 Nov 3;40(11):972-981. Epub 2018 Sep 3.

a Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.

Introduction: Mild traumatic brain injury (MTBI) can cause persistent functional deficits and healthcare burden. Understanding the association between intracranial contusions and outcome may aid in MTBI treatment and prognosis.

Methods: MTBI patients with Glasgow Coma Scale 13-15 and 6-month outcomes [Glasgow Outcome Scale-Extended (GOSE)], without polytrauma from the prospective TRACK-TBI Pilot study were analyzed. Read More

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http://dx.doi.org/10.1080/01616412.2018.1505416DOI Listing
November 2018
7 Reads
1.450 Impact Factor

Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion.

J Neurotrauma 2018 Oct 4. Epub 2018 Oct 4.

1 Department of Neurosurgery, University of Maryland School of Medicine , Baltimore, Maryland.

In severe traumatic brain injury (TBI), contusions often are worsened by contusion expansion or hemorrhagic progression of contusion (HPC), which may double the original contusion volume and worsen outcome. In humans and rodents with contusion-TBI, sulfonylurea receptor 1 (SUR1) is upregulated in microvessels and astrocytes, and in rodent models, blockade of SUR1 with glibenclamide reduces HPC. SUR1 does not function by itself, but must co-assemble with either KIR6. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.5986
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http://dx.doi.org/10.1089/neu.2018.5986DOI Listing
October 2018
16 Reads

Unusual, Acute, and Delayed Traumatic Torcular Herophili Epidural Hematoma Causing Malignant Encephalocele During Surgery: A Case Report.

Am J Case Rep 2018 Aug 29;19:1030-1034. Epub 2018 Aug 29.

Department of Neurosurgery, Huishan People's Hospital of Wuxi, Wuxi, Jiangsu, China (mainland).

BACKGROUND Traumatic torcular herophili epidural hematoma is a rare and specific type of traumatic brain injury that is technically difficult to treat and, more critically, can lead to malignant encephalocele during the operation. CASE REPORT A 40-year-old man presented to our hospital 2 h after a motor vehicle crash. Emergency cranial CT showed a frontotemporal subdural hematoma; 3 h after the patient was admitted, the GCS score decreased to 8 and cranial CT re-examination showed that the frontotemporal subdural hematoma was significantly larger than before. Read More

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https://www.amjcaserep.com/abstract/index/idArt/910030
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http://dx.doi.org/10.12659/AJCR.910030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124356PMC
August 2018
12 Reads

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol.

Neurobiol Dis 2019 Mar 23;123:110-114. Epub 2018 Jul 23.

University of California, Davis, United States.

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Read More

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http://dx.doi.org/10.1016/j.nbd.2018.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344322PMC
March 2019
9 Reads

What Is the Best Timing of Repeated CT Scan in Mild Head Trauma with an Initially Positive CT Scan?

World Neurosurg 2018 Oct 30;118:e316-e322. Epub 2018 Jun 30.

Department of Neurosurgery, Chieti University G. D'Annunzio, Santo Spirito Hospital, Pescara, Italy.

Background: Mild traumatic brain injury (MTBI) is among the most common causes of emergency admission. Current guidelines have clearly evidenced risk factors and neurologic signs that should suggest computed tomography (CT) of the head at admission and indications for the first repeated CT scan. However, the role and frequency of further repeated CT scans after an initially positive scan are still unclear. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.185DOI Listing
October 2018
3 Reads

Establishment of a precise novel brain trauma model in a large animal based on injury of the cerebral motor cortex.

J Neurosci Methods 2018 Sep 28;307:95-105. Epub 2018 Jun 28.

Institution of Brain Trauma and Neurology Disease, Key laboratory of neurotrauma repair of Tianjin, Affiliated Hospital of Logistics University of PAP, Chenglin Road No.220, Tianjin 300162, China. Electronic address:

Background: Animal models are essential in simulating clinical diseases and facilitating relevant studies.

New Method: We established a precise canine model of traumatic brain injury (TBI) based on cerebral motor cortex injury which was confirmed by neuroimaging, electrophysiology, and a series of motor function assessment methods. Twelve beagles were divided into control, sham, and model groups. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2018.06.025DOI Listing
September 2018
16 Reads

Neuroprotective Effects of Cyclosporine in a Porcine Pre-Clinical Trial of Focal Traumatic Brain Injury.

J Neurotrauma 2018 Jul 24. Epub 2018 Jul 24.

1 Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.

Mitochondrial dysfunction is thought to be a hallmark of traumatic brain injury (TBI) and plays a pivotal role in the resulting cellular injury. Cyclophilin D-mediated activation of the mitochondrial permeability transition pore has been suggested to contribute to this secondary injury cascade. Cyclosporine possesses neuroprotective properties that have been attributed to the desensitization of mitochondrial permeability transition pore activation. Read More

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http://dx.doi.org/10.1089/neu.2018.5706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306685PMC
July 2018
12 Reads

Dynamic correlation of diffusion tensor imaging and neurological function scores in beagles with spinal cord injury.

Neural Regen Res 2018 May;13(5):877-886

School of Rehabilitation Medicine, Capital Medical University; Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center; Center of Neural Injury and Repair, Beijing Institute for Brain Disorders; China Rehabilitation Science Institute; Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China.

Exploring the relationship between different structure of the spinal cord and functional assessment after spinal cord injury is important. Quantitative diffusion tensor imaging can provide information about the microstructure of nerve tissue and can quantify the pathological damage of spinal cord white matter and gray matter. In this study, a custom-designed spinal cord contusion-impactor was used to damage the T spinal cord of beagles. Read More

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http://dx.doi.org/10.4103/1673-5374.232485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998642PMC
May 2018
10 Reads

Application of a Grading System in the Treatment of Frontal Lobe Contusion in High-Altitude Regions.

World Neurosurg 2018 Aug 29;116:e975-e982. Epub 2018 May 29.

Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, People's Republic of China. Electronic address:

Objective: With the development of frontal contusion, patients may rapidly deteriorate or even die. Experience in the treatment of frontal contusion in high-altitude regions is limited; thus, we explore a grading system for the treatment of frontal lobe contusion.

Methods: A total of 446 patients with frontal contusions in a high-altitude regions were reviewed retrospectively. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.05.144DOI Listing
August 2018
5 Reads

Detection of small traumatic hemorrhages using a computer-generated average human brain CT.

J Med Imaging (Bellingham) 2018 Apr 21;5(2):024004. Epub 2018 May 21.

University of Twente, MIRA Institute for Biomedical Engineering and Technical Medicine, Enschede, The Netherlands.

Computed tomography is a standard diagnostic imaging technique for patients with traumatic brain injury (TBI). A limitation is the poor-to-moderate sensitivity for small traumatic hemorrhages. A pilot study using an automatic method to detect hemorrhages [Formula: see text] in diameter in patients with TBI is presented. Read More

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http://dx.doi.org/10.1117/1.JMI.5.2.024004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960809PMC
April 2018
1 Read

Clinico-radiologic Profile of Pediatric Traumatic Brain Injury in Western Rajasthan.

J Neurosci Rural Pract 2018 Apr-Jun;9(2):226-231

Department of Medicine, AIIMS, Jodhpur, Rajasthan, India.

Objective: The aim of this study was to evaluate clinico-radiological profile and outcome of pediatric traumatic brain injury (TBI).

Design: Prospective observational study.

Setting: Intensive Care Unit, ward and OPD of Pediatrics, Dr. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_269_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912029PMC
May 2018
3 Reads

The clinical characteristics of posttraumatic epilepsy following moderate-to-severe traumatic brain injury in children.

Seizure 2018 May 20;58:29-34. Epub 2018 Mar 20.

The pediatric Neurosurgery Unit, Rambam Health Care Campus, Haifa, Israel. Electronic address:

Purpose: Children with traumatic brain injury (TBI) are at increased risk of posttraumatic epilepsy (PTE); the risk increases according to TBI severity. We examined the long-term incidence and risk factors for developing PTE in a cohort of children hospitalised at one medical centre with moderate or severe TBI.

Methods: Moderate brain injury was classified as Glasgow Coma Score on Arrival (GCSOA) of 9-13, and severe brain injury as GCSOA ≤8. Read More

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http://dx.doi.org/10.1016/j.seizure.2018.03.018DOI Listing
May 2018
4 Reads

Stretchable Transparent Electrode Arrays for Simultaneous Electrical and Optical Interrogation of Neural Circuits in Vivo.

Nano Lett 2018 05 9;18(5):2903-2911. Epub 2018 Apr 9.

School of Life Sciences , Tsinghua University , Beijing 100084 , China.

Recent developments of transparent electrode arrays provide a unique capability for simultaneous optical and electrical interrogation of neural circuits in the brain. However, none of these electrode arrays possess the stretchability highly desired for interfacing with mechanically active neural systems, such as the brain under injury, the spinal cord, and the peripheral nervous system (PNS). Here, we report a stretchable transparent electrode array from carbon nanotube (CNT) web-like thin films that retains excellent electrochemical performance and broad-band optical transparency under stretching and is highly durable under cyclic stretching deformation. Read More

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http://dx.doi.org/10.1021/acs.nanolett.8b00087DOI Listing
May 2018
18 Reads

Predicting Dural Tear in Compound Depressed Skull Fractures: A Prospective Multicenter Correlational Study.

World Neurosurg 2018 Jun 26;114:e833-e839. Epub 2018 Mar 26.

Department of Neurosurgery, Haukeland University Hospital, Bergen, Norway.

Background: Compound depressed skull fracture (DSF) is a neurosurgical emergency. Preoperative knowledge of dural status is indispensable for treatment decision making. This study aimed to determine predictors of dural tear from clinical and imaging characteristics in patients with compound DSF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183057
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http://dx.doi.org/10.1016/j.wneu.2018.03.095DOI Listing
June 2018
21 Reads
2.420 Impact Factor

A Case of Traumatic Brain Injury Presenting with Musical Hallucinations.

Case Rep Neurol 2018 Jan-Apr;10(1):7-11. Epub 2018 Jan 16.

Department of Rehabilitation Medicine, Fukui General Hospital, Fukui, Japan.

A 67-year-old woman was hospitalized for rehabilitation from the after effects of a traumatic brain injury. In addition to memory impairment, attention disorder, and executive dysfunction, she experienced musical hallucinations. Brain magnetic resonance imaging revealed cerebral contusion in the bilateral temporal lobes and the left frontal lobe. Read More

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http://dx.doi.org/10.1159/000481451DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836244PMC
January 2018

Motorcycle helmets and cervical spine injuries: a 5-year experience at a Level 1 trauma center.

J Neurosurg Spine 2018 Jun 6;28(6):607-611. Epub 2018 Mar 6.

OBJECTIVE Motorcycle helmets have been shown to decrease the incidence and severity of traumatic brain injury due to motorcycle crashes. Despite this proven efficacy, some previous reports and speculation suggest that helmet use is associated with a higher likelihood of cervical spine injury (CSI). In this study, the authors examine 1061 cases of motorcycle crash victims who were treated during a 5-year period at a Level 1 trauma center to investigate the association of helmet use with the incidence and severity of CSI. Read More

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http://dx.doi.org/10.3171/2017.7.SPINE17540DOI Listing
June 2018
4 Reads

Value of Ventricular Intracranial Pressure Monitoring for Traumatic Bifrontal Contusions.

World Neurosurg 2018 May 1;113:e690-e701. Epub 2018 Mar 1.

Department of Neurosurgery, 101st Hospital of PLA, Wuxi, China. Electronic address:

Objective: To investigate clinical efficacy of and optimal therapeutic strategy for ventricular intracranial pressure monitoring (V-ICPM) in patients with traumatic bifrontal contusions (TBCs).

Methods: From 8760 patients with traumatic brain injury treated between January 2010 and January 2016, a retrospective analysis was performed on 105 patients with TBCs who underwent V-ICPM and 282 patients with TBCs who did not. All patients underwent treatment at the 101st Hospital of PLA, Wuxi, China. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.02.122DOI Listing
May 2018
50 Reads

Dynamic diffusion tensor imaging of spinal cord contusion: A canine model.

J Neurosci Res 2018 Jun 27;96(6):1093-1103. Epub 2018 Feb 27.

State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

This study aimed to explore the dynamic diffusion tensor imaging (DTI) of changes in spinal cord contusion using a canine model of injury involving rostral and caudal levels. In this study, a spinal cord contusion model was established in female dogs using a custom-made weight-drop lesion device. DTI was performed on dogs with injured spinal cords (n=7) using a Siemens 3. Read More

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http://dx.doi.org/10.1002/jnr.24222DOI Listing
June 2018
5 Reads

Impact of timing of ventriculoperitoneal shunt placement on outcome in posttraumatic hydrocephalus.

J Neurosurg 2018 Feb 23:1-12. Epub 2018 Feb 23.

Radiology Imaging Associates, Englewood, Colorado.

OBJECTIVE Posttraumatic hydrocephalus (PTH) is a frequent sequela of traumatic brain injury (TBI) and complication of related cranial surgery. The roles of PTH and the timing of cerebrospinal fluid (CSF) shunt placement in TBI outcome have not been well described. The goal of this study was to assess the impact of hydrocephalus and timing of ventriculoperitoneal (VP) shunt placement on outcome during inpatient rehabilitation after TBI. Read More

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http://dx.doi.org/10.3171/2017.7.JNS17555DOI Listing
February 2018
6 Reads

Fatal Road Traffic Vehicle Collisions With Pedestrian Victims: Forensic Postmortem Computed Tomography and Autopsy Correlation.

Am J Forensic Med Pathol 2018 Jun;39(2):130-140

From the Department of Forensic Medicine and Imaging, Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland.

Fatal car-to-pedestrian collisions regularly appear in the forensic pathologist's routine, particularly in places of extended urbanization. Postmortem computed tomography has gained an exceptional role to supplement autopsy worldwide, giving information that is supplementary or complimentary to conventional autopsy. In this retrospective study, a total number of 320 findings in a series of 21 pedestrians fatally hit by cars and trucks of both postmortem computed tomography and autopsy were correlated. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000382DOI Listing
June 2018
5 Reads

Human brain trauma severity is associated with lectin complement pathway activation.

J Cereb Blood Flow Metab 2018 02 9:271678X18758881. Epub 2018 Feb 9.

1 IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.

We explored the involvement of the lectin pathway of complement in post-traumatic brain injury (TBI) pathophysiology in humans. Brain samples were obtained from 28 patients who had undergone therapeutic contusion removal, within 12 h (early) or from >12 h until five days (late) from injury, and from five non-TBI patients. Imaging analysis indicated that lectin pathway initiator molecules (MBL, ficolin-1, ficolin-2 and ficolin-3), the key enzymes MASP-2 and MASP-3, and the downstream complement components (C3 fragments and TCC) were present inside and outside brain vessels in all contusions. Read More

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http://dx.doi.org/10.1177/0271678X18758881DOI Listing
February 2018
7 Reads

Autopsy Case of a Penetrating Wound to the Left Cerebral Hemisphere Caused by an Accidental Shooting With a Crossbow.

Am J Forensic Med Pathol 2018 Jun;39(2):164-168

A crossbow is a bow that shoots an arrow when a gun-like trigger is pulled. Deaths caused by accidental crossbow shootings are extremely rare. Here we describe an autopsy case of a penetrating wound to the left cerebral hemisphere caused by an accidental shooting with a crossbow. Read More

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http://dx.doi.org/10.1097/PAF.0000000000000381DOI Listing
June 2018
14 Reads

Blossoming contusions: identifying factors contributing to the expansion of traumatic intracerebral hemorrhage.

J Neurosurg 2018 Nov;129(5):1305-1316

1Department of Neurosurgery, Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Here, the authors examined the factors involved in the volumetric progression of traumatic brain contusions. The variables significant in this progression are identified, and the expansion rate of a brain bleed can now effectively be predicted given the presenting characteristics of the patient. Read More

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http://dx.doi.org/10.3171/2017.7.JNS17988DOI Listing
November 2018
15 Reads

Conventional Computed Tomography and Magnetic Resonance in Brain Concussion.

Neuroimaging Clin N Am 2018 Feb 27;28(1):15-29. Epub 2017 Oct 27.

Diagnostic and Interventional Imaging Department, El Bosque University, Hospital Universitario Fundacion Santa Fe de Bogota, Calle 119 # 7 - 75, Bogota DC 110111, Colombia.

Conventional neuroimaging is still the mainstay in the assessment of the acute, follow-up, and chronic settings of concussion and mild traumatic brain injury (mTBI). Computed tomography (CT) is preferred for the initial assessment of acute mTBI, repeat evaluation in acute mTBI with neurologic deterioration, and cautious use in children with mTBI. Clinical rules have been developed to identify pediatric and adult patients with mTBI who can safely forego CT. Read More

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http://dx.doi.org/10.1016/j.nic.2017.09.006DOI Listing
February 2018
3 Reads

Diffusion tensor imaging of spinal cord parenchyma lesion in rat with chronic spinal cord injury.

Magn Reson Imaging 2018 04 14;47:25-32. Epub 2017 Nov 14.

Beijing Key Laboratory for Biomaterials and Neural Regeneration, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China; Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. Electronic address:

Purpose: Adequate evaluation of spinal cord parenchyma and accurate identification of injury range are considered two premises for the research and treatment of chronic spinal cord injury (SCI). Diffusion tensor imaging (DTI) provides information about water diffusion in spinal cord, and thus makes it possible to realize these premises.

Method: In this study, we conducted magnetic resonance imaging (MRI) for Wistar rats 84days after spinal cord contusion. Read More

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http://dx.doi.org/10.1016/j.mri.2017.11.009DOI Listing
April 2018
10 Reads

Low-intensity pulsed ultrasound improves behavioral and histological outcomes after experimental traumatic brain injury.

Sci Rep 2017 Nov 14;7(1):15524. Epub 2017 Nov 14.

Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan.

The purpose of this study was to investigate the neuroprotective effects of low-intensity pulsed ultrasound (LIPUS) on behavioral and histological outcomes in a mouse model of traumatic brain injury (TBI). Mice subjected to controlled cortical impact injury were treated with LIPUS in the injured region daily for a period of 4 weeks. The effects of LIPUS on edema were observed by MR imaging in the mouse brain at 1 and 4 days following TBI. Read More

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http://www.nature.com/articles/s41598-017-15916-2
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http://dx.doi.org/10.1038/s41598-017-15916-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686128PMC
November 2017
2 Reads

Agmatine Modulates the Phenotype of Macrophage Acute Phase after Spinal Cord Injury in Rats.

Exp Neurobiol 2017 Oct 16;26(5):278-286. Epub 2017 Oct 16.

Department of Anatomy, Yonsei University College of Medicine, Seoul 03722, Korea.

Agmatine is a decarboxylated arginine by arginine decarboxylase. Agmatine is known to be a neuroprotective agent. It has been reported that agmatine works as a NMDA receptor blocker or a competitive nitric oxide synthase inhibitor in CNS injuries. Read More

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http://dx.doi.org/10.5607/en.2017.26.5.278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661060PMC
October 2017
29 Reads

Minimizing Retraction by Pia-Arachnoidal 10-0 Sutures in Intrasulcal Dissection.

Oper Neurosurg (Hagerstown) 2018 Jul;15(1):10-14

Department of Neurosurgery, University of Wisconsin-Madison, Madison, Wisconsin.

Background: In contemporary microneurosurgery reducing retraction-induced injury to the brain is essential. Self-retaining retractor systems are commonly used to improve visualization and decrease the repetitive microtrauma, but sometimes self-retaining retractor systems can be cumbersome and the force applied can cause focal ischemia or contusions. This may increase the morbidity and mortality. Read More

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http://dx.doi.org/10.1093/ons/opx193DOI Listing
July 2018
39 Reads

Pneumatoceles in pediatric blunt trauma: Common and benign.

J Pediatr Surg 2018 Jul 7;53(7):1310-1312. Epub 2017 Aug 7.

Department of Surgery, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Boston, MA.

Introduction: Traumatic pneumatoceles are reported to be rare in children and to have an uncertain clinical significance. We report a single institution series of traumatic pneumatoceles to better define their frequency and clinical significance.

Methods: After obtaining approval from the IRB, data were extracted from the trauma registry of a level 1 pediatric trauma center on children diagnosed with a pulmonary contusion (International Classification of Diseases-9th edition diagnosis codes: 861. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.08.002DOI Listing
July 2018
5 Reads

Traumatic brain injury: Comparison between autopsy and ante-mortem CT.

J Forensic Leg Med 2017 Nov 26;52:62-69. Epub 2017 Aug 26.

Institute of Legal Medicine, Ludwig-Maximilians University, Munich, Nussbaumstraße 26, D-80336 Munich, Germany.

Purpose: The aim of this study was to compare pathological findings after traumatic brain injury between autopsy and ante-mortem computed tomography (CT). A second aim was to identify changes in these findings between the primary posttraumatic CT and the last follow-up CT before death.

Methods: Through the collaboration between clinical radiology and forensic medicine, 45 patients with traumatic brain injury were investigated. Read More

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http://dx.doi.org/10.1016/j.jflm.2017.08.007DOI Listing
November 2017
19 Reads

Fractional anisotropy is a marker in early-stage spinal cord injury.

Brain Res 2017 Oct 29;1672:44-49. Epub 2017 Jul 29.

Department of Orthopaedics, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, China. Electronic address:

This study was designed to investigate whether fractional anisotropy (FA) contributes to study pathologic changes in SCI. Here rats were divided into a control group and three injury groups. Those in the injury groups were administered a mild, moderate, and severe contusion injury at the T10 vertebral level, respectively. Read More

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http://dx.doi.org/10.1016/j.brainres.2017.07.024DOI Listing
October 2017
4 Reads

Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats.

Exp Brain Res 2017 10 19;235(10):3033-3048. Epub 2017 Jul 19.

Neural Injury Research Unit, School of Life Sciences, Faculty of Science, University of Technology Sydney, P.O. Box 123, Broadway, NSW, 2007, Australia.

Systemic administration of a Connexin43 mimetic peptide, Peptide5, has been shown to reduce secondary tissue damage and improve functional recovery after spinal cord injury (SCI). This study investigated safety measures and potential off-target effects of Peptide5 systemic administration. Rats were subjected to a mild contusion SCI using the New York University impactor. Read More

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http://dx.doi.org/10.1007/s00221-017-5023-3DOI Listing
October 2017
6 Reads

Clinical and Radiological Presentations and Management of Blunt Splenic Trauma: A Single Tertiary Hospital Experience.

Med Sci Monit 2017 Jul 12;23:3383-3392. Epub 2017 Jul 12.

Department of Surgery, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Splenic injury is the leading cause of major bleeding after blunt abdominal trauma. We examined the clinical and radiological presentations, management, and outcome of blunt splenic injuries (BSI) in our institution. MATERIAL AND METHODS A retrospective study of BSI patients between 2011 and 2014 was conducted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5519223PMC
July 2017
8 Reads

Disappearance of the Hemorrhagic Component of the Frontal Contusion Possibly due to Redistribution of the Hematoma within the Subarachnoid Space: A Case Report.

Pediatr Neurosurg 2017 10;52(4):268-270. Epub 2017 Jun 10.

Department of Neurosurgery, King George's Medical University, Lucknow, India.

Posttraumatic hemorrhagic contusions are a common sequel of traumatic brain injuries. They occur in around 8% of all traumatic brain injuries. Spontaneous resolution of acute subdural and acute extradural hematomas, although rare, is a recognized entity, but spontaneous resolution of the hemorrhagic component of a contusion within 24 h has not been reported in the literature. Read More

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http://dx.doi.org/10.1159/000475532DOI Listing
May 2018
11 Reads

Lesson of the month 2: Contusion confusion.

Clin Med (Lond) 2017 Jun;17(3):282-283

Musgrove Park Hospital, Taunton, UK.

This lesson of the month highlights that certain radiology terminology may be used to report bleeding on head computerised tomography (CT) reports. On-call junior doctors should not be expected to interpret CT head images, so often their decisions will be based on the written report. The wording used can change the clinical decision and therefore the treatment given by a junior doctor. Read More

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http://dx.doi.org/10.7861/clinmedicine.17-3-282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297574PMC
June 2017
25 Reads

Complicated Mild Traumatic Brain Injury and the Need for Imaging Surveillance.

World Neurosurg 2017 Sep 11;105:265-269. Epub 2017 May 11.

Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Objective: To evaluate the need for repeat head computed tomography (CT) in patients with complicated mild traumatic brain injury (TBI) determined nonoperative after the first head CT.

Methods: A total of 380 patients with mild TBI and a positive head CT not needing surgery were included. Changes between first and second head CT were categorized as decreased, increased, or stable. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.05.008DOI Listing
September 2017
22 Reads

Transoral Intracranial Injury via Middle Skull Base by a Blunt Chopstick in a Child.

World Neurosurg 2017 Jul 21;103:952.e11-952.e17. Epub 2017 Apr 21.

Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Electronic address:

Background: Transoral penetrating injury from a blunt-tipped chopstick is unusual and should be promptly dealt with because it is associated with high morbidity and mortality.

Case Description: We report a case of a 2-year-old girl who sustained a transoral penetrating brain injury after falling onto a bamboo chopstick, which penetrated through the hard palate and eventually led to middle skull base fracture as well as temporal lobe laceration and contusion. The chopstick was successfully extracted via a transoral approach followed by administration of empirical antibiotics and anticonvulsants. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.04.084DOI Listing
July 2017
5 Reads

Clinical application of the supraorbital key-hole approach to the treatment of unilateral-dominant bilateral frontal contusions.

Oncotarget 2017 Jul;8(29):48343-48349

Department of Neurosurgery, The First People's Hospital of Kunshan Affiliated with Jiangsu University, Suzhou, P. R. China.

We compared the surgical efficacy of the supraorbital key-hole approach (SKA) to conventional unilateral frontotemporal craniotomy (UFTC) for the treatment of patients with unilateral-dominant bilateral frontal contusions (BFCs). A retrospective analysis of 62 patients with unilateral-dominant BFCs who underwent surgery at our institute between 2014 and 2017 was performed. There were 26 patients who underwent SKA (group A) and 36 who underwent UFTC (group B). Read More

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http://dx.doi.org/10.18632/oncotarget.15983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5564652PMC
July 2017
12 Reads

Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury.

Mol Neurobiol 2018 03 1;55(3):2454-2470. Epub 2017 Apr 1.

Department of Neurology, University of Pittsburgh, Pittsburgh, PA, 15213, USA.

Traumatic brain injury (TBI) triggers endoplasmic reticulum (ER) stress and impairs autophagic clearance of damaged organelles and toxic macromolecules. In this study, we investigated the effects of the post-TBI administration of docosahexaenoic acid (DHA) on improving hippocampal autophagy flux and cognitive functions of rats. TBI was induced by cortical contusion injury in Sprague-Dawley rats, which received DHA (16 mg/kg in DMSO, intraperitoneal administration) or vehicle DMSO (1 ml/kg) with an initial dose within 15 min after the injury, followed by a daily dose for 3 or 7 days. Read More

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http://dx.doi.org/10.1007/s12035-017-0504-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623615PMC
March 2018
43 Reads

Trans-nasal-trans-sphenoidal brain injury by a fencing foil: an unusual case report and brief literature review.

J Sports Med Phys Fitness 2017 Nov 22;57(11):1494-1498. Epub 2017 Feb 22.

Clinic of Neurosurgery, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ministry of Health, Ankara, Turkey.

In this report, the authors present an unusual case of a 10-year-old child who suffered a severe headache and rhinorrhea that occurred as a result of fencing foil sports injury via trans-nasal-trans-sphenoidal (TNTS) pathway. Following trauma, the child had shown neurological symptoms such a pupil dilatation, change in consciousness and mild hemiparesia. Imaging demonstrated destruction of bone structures including posterior wall of sphenoid sinus and antero-superior part of sella turcica, and also a contusion at right thalamic region. Read More

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http://dx.doi.org/10.23736/S0022-4707.17.07133-XDOI Listing
November 2017
5 Reads