681 results match your criteria Brain Contusion Imaging


The intersection of cerebral fat embolism syndrome and traumatic brain injury: a literature review and case series.

Brain Inj 2020 Jun 16:1-8. Epub 2020 Jun 16.

Department of Physical Medicine and Rehabilitation, Anschutz Medical Campus, University of Colorado , Aurora, Colorado, USA.

Objective: To review the historical, clinical, radiographic, and outcome characteristics of individuals diagnosed with an acquired brain injury (ABI) due to cerebral fat embolism syndrome (CFES) with and without features of traumatic brain injury (TBI).

Methods: A retrospective chart review of individuals with the diagnosis of CFES admitted to an ABI rehabilitation program. Cases were divided into two cohorts 1) individuals with evidence of classic features of CFES alone, and 2) individuals with evidence of CFES in conjunction with features of TBI. Read More

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http://dx.doi.org/10.1080/02699052.2020.1776898DOI Listing

Slow blood-to-brain transport underlies enduring barrier dysfunction in American football players.

Brain 2020 Jun;143(6):1826-1842

Departments of Physiology and Cell Biology, Brain and Cognitive Sciences, The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Repetitive mild traumatic brain injury in American football players has garnered increasing public attention following reports of chronic traumatic encephalopathy, a progressive tauopathy. While the mechanisms underlying repetitive mild traumatic brain injury-induced neurodegeneration are unknown and antemortem diagnostic tests are not available, neuropathology studies suggest a pathogenic role for microvascular injury, specifically blood-brain barrier dysfunction. Thus, our main objective was to demonstrate the effectiveness of a modified dynamic contrast-enhanced MRI approach we have developed to detect impairments in brain microvascular function. Read More

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http://dx.doi.org/10.1093/brain/awaa140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297017PMC
June 2020
9.196 Impact Factor

Effect of simultaneous combined treadmill training and magnetic stimulation on spasticity and gait impairments following cervical spinal cord injury (C-SCI).

J Neurotrauma 2020 Apr 28. Epub 2020 Apr 28.

Malcom Randall VA Medical Center, 19992, Brain Rehabilitation Research Center , Gainesville, Florida, United States.

Cervical spinal cord injury (CSCI) can induce life-long disabilities, including spasticity and gait impairments. The objective of this preclinical study was to evaluate the therapeutic effects of simultaneous and combined early locomotor treadmill training (Tm) and injury site magnetic stimulation (TMSsc) on spasticity and gait impairments in a rat model of C6/7 moderate contusion SCI. Tm training was initiated at post-injury (PI) day 8, whereas TMS treatment was added to Tm 14 days PI, and then the combined therapy (TMSTm) was continued for 6 weeks. Read More

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http://dx.doi.org/10.1089/neu.2019.6961DOI Listing

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury.

J Vis Exp 2020 Feb 10(156). Epub 2020 Feb 10.

Fralin Biomedical Research Institute at Virginia Tech Carilion; School of Neuroscience, Virginia Tech; Department of Biological Sciences, Virginia Tech;

Traumatic brain injury (TBI) is a leading cause of acquired epilepsy. TBI can result in a focal or diffuse brain injury. Focal injury is a result of direct mechanical forces, sometimes penetrating through the cranium, creating a direct lesion in the brain tissue. Read More

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http://dx.doi.org/10.3791/60360DOI Listing
February 2020

Astrocyte-selective AAV-ADAMTS4 gene therapy combined with hindlimb rehabilitation promotes functional recovery after spinal cord injury.

Exp Neurol 2020 May 7;327:113232. Epub 2020 Feb 7.

Department of Anatomy and Medical Imaging, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, 85 Park Road, Grafton, New Zealand; Centre for Brain Research, University of Auckland, Auckland, 85 Park Road, Grafton, New Zealand. Electronic address:

Chondroitin sulphate proteoglycans (CSPGs) are inhibitors to axon regeneration and plasticity. A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4) is a human enzyme that catalyses the proteolysis of CSPG protein cores. Infusion of ADAMTS4 into the damaged spinal cord was previously shown to improve functional recovery SCI, however, this therapy is limited in its enzyme form. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113232DOI Listing

Relationship between Measures of Cerebrovascular Reactivity and Intracranial Lesion Progression in Acute Traumatic Brain Injury Patients: A CENTER-TBI Study.

J Neurotrauma 2020 Jul 1;37(13):1556-1565. Epub 2020 Apr 1.

Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom.

Failure of cerebral autoregulation has been linked to unfavorable outcome after traumatic brain injury (TBI). Preliminary evidence from a small, retrospective, single-center analysis suggests that autoregulatory dysfunction may be associated with traumatic lesion expansion, particularly for pericontusional edema. The goal of this study was to further explore these associations using prospective, multi-center data from the Collaborative European Neurotrauma Effectiveness Research in TBI (CENTER-TBI) and to further explore the relationship between autoregulatory failure, lesion progression, and patient outcome. Read More

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http://dx.doi.org/10.1089/neu.2019.6814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307675PMC

[An abnormal CT scan following a mild traumatic brain injury; what then?]

Ned Tijdschr Geneeskd 2019 10 29;163. Epub 2019 Oct 29.

Medisch Spectrum Twente, afd. Neurologie, Enschede.

CT scan reveals traumatic intracranial abnormalities in fewer than 10% of patients following mild traumatic brain injury (mTBI). Management policy in these patients is not clear. Clinical or radiological deterioration occurs in 10-20% of this risk group, usually within 24 hours and often without neurosurgical consequences. Read More

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October 2019
2 Reads

Evaluation of the necessity of whole-body scan tomography in cases with head trauma.

Ulus Travma Acil Cerrahi Derg 2019 Nov;25(6):622-627

Department of Emergency Medicine, Çukurova University Faculty of Medicine, Adana-Turkey.

Background: In our study, we have tried to find out how necessary whole-body computed tomography (WBCT) is to detect other body injuries that may accompany the patients, evaluating head trauma cases with WBCT.

Methods: In our study, we included 198 patients, who were referred to our hospital's emergency service after head trauma, had brain lesions detected in brain tomography (BT), had no additional examination findings and who underwent WBCT. In this retrospective study, patients' age, gender, type of lesion in brain CT, Glasgow Coma Scale (GCS) values and WBCT findings were examined. Read More

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http://dx.doi.org/10.14744/tjtes.2019.42675DOI Listing
November 2019
0.379 Impact Factor

Role of repeat CT in mild to moderate head injury: an institutional study.

Neurosurg Focus 2019 11;47(5):E2

Objective: Patients with traumatic brain injury (TBI) often undergo repeat head CT scans to identify the possible progression of injury. The objective of this study is to evaluate the need for routine repeat head CT scans in patients with mild to moderate head injury and an initial positive abnormal CT scan.

Methods: This is a retrospective study of patients presenting to the emergency department from January 2016 to December 2017 with Glasgow Coma Scale (GCS) scores > 8 and an initial abnormal CT scan, who underwent repeat CT during their in-hospital medical management. Read More

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http://dx.doi.org/10.3171/2019.8.FOCUS19527DOI Listing
November 2019
3 Reads
2.105 Impact Factor

Cavitation-induced traumatic cerebral contusion and intracerebral hemorrhage in the rat brain by using an off-the-shelf clinical shockwave device.

Sci Rep 2019 Oct 30;9(1):15614. Epub 2019 Oct 30.

Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.

Traumatic cerebral contusion and intracerebral hemorrhages (ICH) commonly result from traumatic brain injury and are associated with high morbidity and mortality rates. Current animal models require craniotomy and provide less control over injury severity. This study proposes a highly reproducible and controllable traumatic contusion and ICH model using non-invasive extracorporeal shockwaves (ESWs). Read More

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http://dx.doi.org/10.1038/s41598-019-52117-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6821893PMC
October 2019

The White Cerebellum Sign: An Under-recognized Red Flag Finding with Grave Prognosis.

J Coll Physicians Surg Pak 2019 11;29(11):1123-1124

Department of Paediatrics, Torbay Hospital, Torquay, UK.

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http://dx.doi.org/10.29271/jcpsp.2019.11.1123DOI Listing
November 2019
0.318 Impact Factor

Correlation between the skull base fracture and the incidence of intracranial hemorrhage in patients with traumatic brain injury.

Chin J Traumatol 2019 Oct 16;22(5):286-289. Epub 2019 Aug 16.

Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran, Dr. Hasan Sadikin Hospital, Bandung, Indonesia.

Purpose: A head injury (HI) may cause a skull fracture, which may or may not be associated with injury to the brain. In essence, a skull base fracture (SBF) is a linear fracture at the base of the skull. Loss of consciousness and Glasgow coma score (GCS) may vary depending on an associated intracranial pathology. Read More

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http://dx.doi.org/10.1016/j.cjtee.2019.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823676PMC
October 2019
1 Read

Treatment of Traumatic Depressed Compound Skull Fractures.

J Craniofac Surg 2019 Oct;30(7):2239-2244

Wannan Medical College, Department of Neurosurgery, Yi-Ji Shan Hospital, Wuhu, China.

Background: A skull fracture widely occurs in patients with traumatic brain injury, leading to intracranial hematoma, brain contusion, and intracranial infection. It also influences the prognosis and death of patients. This study aimed to discuss cases of patients with comminuted skull fractures. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005982DOI Listing
October 2019
3 Reads

First Intracranial Pressure Monitoring or First Operation: Which One Is Better?

World Neurosurg 2020 Jan 31;133:e105-e114. Epub 2019 Aug 31.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. Electronic address:

Background: For patients with TBI, traditional methods such as clinical examination and imaging data are the primary references used for deciding whether to operate or not. Intracranial pressure (ICP) monitoring based on lateral ventricles or parenchymal pressure is a more direct reflection of ICP. However, the research on whether the outcome results of ICP monitoring are better than results based on clinical signs and imaging is sparse. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.08.166DOI Listing
January 2020

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury.

Front Cell Neurosci 2019 8;13:307. Epub 2019 Aug 8.

Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.

The neuroinflammatory response to traumatic brain injury (TBI) is critical to both neurotoxicity and neuroprotection, and has been proposed as a potentially modifiable driver of secondary injury in animal and human studies. Attempts to broadly target immune activation have been unsuccessful in improving outcomes, in part because the precise cellular and molecular mechanisms driving injury and outcome at acute, subacute, and chronic time points after TBI remain poorly defined. Microglia play a critical role in neuroinflammation and their persistent activation may contribute to long-term functional deficits. Read More

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http://dx.doi.org/10.3389/fncel.2019.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6694299PMC
August 2019
4.289 Impact Factor

Neuroradiological Changes Following Single or Repetitive Mild TBI.

Front Syst Neurosci 2019 2;13:34. Epub 2019 Aug 2.

Center for Translational NeuroImaging, Northeastern University, Boston, MA, United States.

Objectives: To test the hypothesis that there are differences in neuroradiological measures between single and repeated mild traumatic brain injury using multimodal MRI.

Methods: A closed-head momentum exchange model was used to produce one or three mild head injuries in young adult male rats compared to non-injured, age and weight-matched controls. Six-seven weeks post-injury, rats were studied for deficits in cognitive and motor function. Read More

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http://dx.doi.org/10.3389/fnsys.2019.00034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688741PMC

Nasogastric Tube Feeding into Brain After Endoscopic Endonasal Transsphenoidal Surgery.

World Neurosurg 2019 Dec 14;132:4-6. Epub 2019 Aug 14.

Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University First Affiliated Hospital, Health Science Center, Shenzhen, China. Electronic address:

The endoscopic endonasal transsphenoidal (EET) approach for skull base tumors has become increasingly popular. We know that bone defects in the skull base can cause cerebrospinal fluid rhinorrhea, but for patients who need to be intubated through the nose, the tube can enter the brain through a skull base bone defect. Nasogastric tube feeding into the brain is a rare occurrence, and this situation can occur only in the case of a skull base defect. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193219
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http://dx.doi.org/10.1016/j.wneu.2019.08.040DOI Listing
December 2019
4 Reads

Magnetic Resonance Imaging Pilot Study of Intravenous Glyburide in Traumatic Brain Injury.

J Neurotrauma 2020 01 27;37(1):185-193. Epub 2019 Aug 27.

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland.

Pre-clinical studies of traumatic brain injury (TBI) show that glyburide reduces edema and hemorrhagic progression of contusions. We conducted a small Phase II, three-institution, randomized placebo-controlled trial of subjects with TBI to assess the safety and efficacy of intravenous (IV) glyburide. Twenty-eight subjects were randomized and underwent a 72-h infusion of IV glyburide or placebo, beginning within 10 h of trauma. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2019.6538
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http://dx.doi.org/10.1089/neu.2019.6538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921286PMC
January 2020
3 Reads

Woman with acute onset involuntary limb movements.

Emerg Med J 2019 Jul;36(7):415-422

Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Clinical Introduction: An 88-year-old woman presented with acute onset of involuntary limb movements for one day. Two days prior she had fallen a suffered a left hip contusion but no head trauma. There was no fever or difficulty breathing. Read More

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http://dx.doi.org/10.1136/emermed-2018-208104DOI Listing
July 2019
1 Read

Delayed Cerebrospinal Fluid Cleft Formation Through the Midbrain and Thalamus Following Hemicraniectomy and Cranioplasty for Acute Subdural Hematoma.

Oper Neurosurg (Hagerstown) 2020 Mar;18(3):E88-E94

Department of Neurosurgery, University of Utah, Salt Lake City, Utah.

Background And Importance: Cerebrospinal fluid (CSF) cleft formation through brain parenchyma following nonpenetrating traumatic brain injury (TBI) is a rare phenomenon. Here we present a unique case of delayed CSF cleft formation months after initial injury.

Clinical Presentation: A 41-yr-old male presented after a fall with a right convexity acute subdural hematoma and ipsilateral frontal contusion. Read More

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http://dx.doi.org/10.1093/ons/opz124DOI Listing
March 2020
6 Reads

The Safety of Multimodality Monitoring Using a Triple-Lumen Bolt in Severe Acute Brain Injury.

World Neurosurg 2019 Oct 10;130:e62-e67. Epub 2019 Jun 10.

Division of Neurosurgery, Main Line Health, Wynnewood, Pennsylvania, USA; Lankenau Institute of Medical Research, Wynnewood, Pennsylvania, USA. Electronic address:

Background: Multimodality monitoring is used frequently to guide care of patients with severe acute brain injury. The aim of this study was to examine the safety and reliability of multimodality monitoring.

Methods: From a prospective observational database at a Level I trauma center, 501 patients, including 300 men and 201 women (mean age 58 ± 39 years) were identified retrospectively. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.05.195DOI Listing
October 2019
8 Reads

Multimodal Evaluation of TMS - Induced Somatosensory Plasticity and Behavioral Recovery in Rats With Contusion Spinal Cord Injury.

Front Neurosci 2019 24;13:387. Epub 2019 Apr 24.

Department of Biomedical Engineering, Michigan State University, East Lansing, MI, United States.

Spinal cord injury (SCI) causes partial or complete damage to sensory and motor pathways and induces immediate changes in cortical function. Current rehabilitative strategies do not address this early alteration, therefore impacting the degree of neuroplasticity and subsequent recovery. The following study aims to test if a non-invasive brain stimulation technique such as repetitive transcranial magnetic stimulation (rTMS) is effective in promoting plasticity and rehabilitation, and can be used as an early intervention strategy in a rat model of SCI. Read More

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http://dx.doi.org/10.3389/fnins.2019.00387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6491761PMC
April 2019
4 Reads

Neurostereologic Lesion Volumes and Spreading Depolarizations in Severe Traumatic Brain Injury Patients: A Pilot Study.

Neurocrit Care 2019 06;30(3):557-568

Department of Neurosurgery, University of Cincinnati (UC) College of Medicine, and UC Gardner Neuroscience Institute, Cincinnati, OH, USA.

Background: Spreading depolarizations (SDs) occur in 50-60% of patients after surgical treatment of severe traumatic brain injury (TBI) and are independently associated with unfavorable outcomes. Here we performed a pilot study to examine the relationship between SDs and various types of intracranial lesions, progression of parenchymal damage, and outcomes.

Methods: In a multicenter study, fifty patients (76% male; median age 40) were monitored for SD by continuous electrocorticography (ECoG; median duration 79 h) following surgical treatment of severe TBI. Read More

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http://dx.doi.org/10.1007/s12028-019-00692-wDOI Listing
June 2019
4 Reads

Dynamic features of brain edema in rat models of traumatic brain injury.

Neuroreport 2019 06;30(9):605-611

Department of Radiology, Chongqing Seventh People's Hospital, Chongqing, China.

We explored the dynamic features of brain edema after traumatic brain injury (TBI) using healthy adult male Wistar rats. After inducing moderate brain injuries in the rats, we divided them randomly among seven groups on the basis of the time elapsed between TBI and examination: 1, 6, 12, 24, 48, 72, and 168 h. All rats were scanned using diffusion-weighted imaging (DWI) to observe tissue changes in the contusion penumbra (CP) after TBI. Read More

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http://dx.doi.org/10.1097/WNR.0000000000001213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6530974PMC
June 2019
16 Reads

Astrocyte-selective AAV gene therapy through the endogenous GFAP promoter results in robust transduction in the rat spinal cord following injury.

Gene Ther 2019 05 8;26(5):198-210. Epub 2019 Apr 8.

Centre for Brain Research, University of Auckland, Auckland, New Zealand.

Adeno-associated viral (AAV) vectors are a promising system for transgene delivery into the central nervous system (CNS) based on their safety profile and long-term gene expression. Gene delivery to the CNS has largely been neuron centric but advances in AAV technology are facilitating the development of approaches to enable transduction of glial cells. Considering the role of astrocytes in the on-going secondary damage in spinal cord injury (SCI), an AAV vector that targets astrocytes could show benefit as a potential treatment. Read More

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http://dx.doi.org/10.1038/s41434-019-0075-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760677PMC
May 2019
17 Reads

Surgical Decision Making in Brain Hemorrhage.

Stroke 2019 05;50(5):1108-1115

From the Neurosurgical Trials Group, Newcastle University.

Background and Purpose- The STICH (Surgical Trial in Lobar Intracerebral Haemorrhage) I and II trials randomized patients with spontaneous intracerebral hemorrhage (ICH) to early surgery or initial conservative treatment. Both were nonsignificant; possibly because surgery has minimal effect on recovery, or because surgery benefits some and harms others. We introduce a new nonparametric method of analysis. Read More

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http://dx.doi.org/10.1161/STROKEAHA.118.022694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6485298PMC

Convolutional Neural Network-Based Automated Segmentation of the Spinal Cord and Contusion Injury: Deep Learning Biomarker Correlates of Motor Impairment in Acute Spinal Cord Injury.

AJNR Am J Neuroradiol 2019 04 28;40(4):737-744. Epub 2019 Mar 28.

From the Departments of Radiology and Biomedical Imaging (D.B.M., S.M.D., J.N., J.F.T.)

Background And Purpose: Our aim was to use 2D convolutional neural networks for automatic segmentation of the spinal cord and traumatic contusion injury from axial T2-weighted MR imaging in a cohort of patients with acute spinal cord injury.

Materials And Methods: Forty-seven patients who underwent 3T MR imaging within 24 hours of spinal cord injury were included. We developed an image-analysis pipeline integrating 2D convolutional neural networks for whole spinal cord and intramedullary spinal cord lesion segmentation. Read More

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http://dx.doi.org/10.3174/ajnr.A6020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048524PMC
April 2019
2 Reads

Behavioral and Structural Effects of Single and Repeat Closed-Head Injury.

AJNR Am J Neuroradiol 2019 04 28;40(4):601-608. Epub 2019 Mar 28.

From the Neuroscience Research Center (Y.-C.J.K., C.-Y.C.)

Background And Purpose: The effects of multiple head impacts, even without detectable primary injury, on subsequent behavioral impairment and structural abnormality is yet well explored. Our aim was to uncover the dynamic changes and long-term effects of single and repetitive head injury without focal contusion on tissue microstructure and macrostructure.

Materials And Methods: We introduced a repetitive closed-head injury rodent model ( = 70) without parenchymal lesions. Read More

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http://dx.doi.org/10.3174/ajnr.A6014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945510PMC
April 2019
1 Read

Combined penetrating trauma of the head, neck, chest, abdomen and scrotum caused by falling from a high altitude: A case report and literature review.

Int Emerg Nurs 2019 05 20;44:1-7. Epub 2019 Mar 20.

Department of Nursing, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

This report describes an extremely rare case of combined penetrating trauma that includes the head, neck, chest, abdomen and scrotum. A 46-year-old male construction worker fell from a 5-metre-high platform, and a rebar that was fixed vertically on the ground penetrated the scrotum into the pelvic and abdominal cavities, passing through the chest, neck, mouth, and nose to the outside of the body through the left side of the head. The rebar penetrated the oral cavity and was palpable on the anterior side of the neck and abdomen. Read More

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http://dx.doi.org/10.1016/j.ienj.2019.01.001DOI Listing
May 2019
20 Reads

Myeloid-Derived Suppressor Cells Infiltrate the Brain and Suppress Neuroinflammation in a Mouse Model of Focal Traumatic Brain Injury.

Neuroscience 2019 05 14;406:457-466. Epub 2019 Mar 14.

Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan. Electronic address:

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive characteristics, which allow them to limit inflammation and facilitate wound healing and recovery. Although MDSCs are a newly-determined cell type that is gaining attention in the immunology field, their neuroimmunological characteristics remain unstudied. In this study, we explored the suppressive role of MDSCs in cerebral inflammatory reactions after focal traumatic brain injury (TBI) using in vivo imaging. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.03.015DOI Listing
May 2019
1 Read

Factors associated with early seizures after surgery of unruptured intracranial aneurysms.

Clin Neurol Neurosurg 2019 03 8;178:93-96. Epub 2019 Feb 8.

Department of Cerebrovascular Surgery, International Medical Center, Saitama Medical University, Hidaka, Japan. Electronic address:

Objective: The aim of the study was to better define the incidence of and risk factors for early seizures after repair of unruptured intracranial aneurysms in modern microsurgical techniques.

Patients And Methods: The medical records of 414 consecutive patients who underwent neck clipping of unruptured intracranial aneurysms in our institution over a 5-year period were retrospectively reviewed. Clinical and neuroimaging variables were analyzed to investigate putative predictors of perioperative seizures using multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.007DOI Listing
March 2019
7 Reads

MR Imaging for Assessing Injury Severity and Prognosis in Acute Traumatic Spinal Cord Injury.

Radiol Clin North Am 2019 Mar 17;57(2):319-339. Epub 2018 Nov 17.

Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143, USA; Brain and Spinal Injury Center, Zuckerberg San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA.

T2-weighted (T2W) imaging is the most important sequence for detection of acute traumatic spinal cord pathology in clinical practice. Intramedullary hemorrhage on T2W imaging is associated with some component of irreversible injury and arguably the most robust MR imaging predictor of injury severity. The MR imaging appearance of the injured spinal cord in the early stages of injury is highly dynamic, and the time delay from injury to imaging must be considered in image interpretation. Read More

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http://dx.doi.org/10.1016/j.rcl.2018.09.004DOI Listing
March 2019
5 Reads

Testing Pathological Variation of White Matter Tract in Adult Rats after Severe Spinal Cord Injury with MRI.

Biomed Res Int 2018 11;2018:4068156. Epub 2018 Nov 11.

Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.

The purpose of this study was to assess the pathological variation in white matter tracts in the adult severe thoracic contusion spinal cord injury (SCI) rat models combined with in vivo magnetic resonance imaging (MRI), as well as the effect of spared white matter (WM) quantity on hindlimb motor function recovery. 7.0T MRI was conducted for all experimental animals before SCI and 1, 3, 7, and 14 days after SCI. Read More

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https://www.hindawi.com/journals/bmri/2018/4068156/
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http://dx.doi.org/10.1155/2018/4068156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6252222PMC
March 2019
27 Reads

Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits.

Int J Mol Sci 2018 Nov 26;19(12). Epub 2018 Nov 26.

Department of Physical Therapy and Rehabilitation Science, University of California, San Francisco, CA 94143, USA.

Traumatic brain injury (TBI) is of particular concern for the aging community since there is both increased incidence of TBI and decreased functional recovery in this population. In addition, TBI is the strongest environmental risk factor for development of Alzheimer's disease and other dementia-related neurodegenerative disorders. Critical changes that affect cognition take place over time following the initial insult. Read More

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http://www.mdpi.com/1422-0067/19/12/3753
Publisher Site
http://dx.doi.org/10.3390/ijms19123753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321529PMC
November 2018
6 Reads

The Diffuse and Severe Traumatic Subarachnoid Hemorrhage Being Hard to Distinguish to Aneurysmal Subarachnoid Hemorrhage.

J Craniofac Surg 2019 Jan;30(1):196-199

Department of Neurosurgery, Tobu Hospital, Yokohama, Japan.

Background: In primary intracerebral hemorrhage, several studies showed that contrast extravasation (CEV) is reported to be an indicator of delayed hematoma expansion, emergent hematoma removal and poor prognosis. On the contrary in head trauma, few researches validated the effectiveness of CEV because of other influences such as subarachnoid hemorrhage (SAH), contusion or brain swelling. The authors experienced a patient showing diffuse SAH caused by traumatic mechanism with acute subdural hematoma (ASDH). Read More

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http://dx.doi.org/10.1097/SCS.0000000000004908DOI Listing
January 2019
28 Reads

Clinical Profile and Autopsy Findings in Fatal Head Injuries.

J Emerg Trauma Shock 2018 Jul-Sep;11(3):205-210

Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, (JIPMER), Puducherry, India.

Aims: This study aims to correlate the autopsy findings with the clinical picture and imaging report in fatal head injury patients.

Settings And Design: A descriptive study conducted at tertiary care hospital in South India from July 2015 to December 2016.

Patients And Methods: All patients with head injuries who were admitted to our Emergency and Trauma Centre and underwent autopsy were included in the study. Read More

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http://dx.doi.org/10.4103/JETS.JETS_127_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182969PMC
November 2018
34 Reads

Fetal closed head injuries following maternal motor vehicle accident: A clinicopathologic case report.

Medicine (Baltimore) 2018 Nov;97(44):e13133

Department of Pediatrics.

Rationale: The clinicopathologic appearance of fetal closed head injury (FCHI) due to a maternal motor vehicle accident has not been fully investigated because of its extreme rarity.

Patients Concern: A 22-year-old woman at 31 weeks of gestation was riding in the front passenger seat of a car, and another rightward-turning car struck the right side of her vehicle.

Diagnosis: Uterine injury with placental abruption was strongly suspected. Read More

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http://dx.doi.org/10.1097/MD.0000000000013133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221710PMC
November 2018
10 Reads

Traumatic Minor Intracranial Hemorrhage: Management by Non-neurosurgeon Consultants in a Regional Trauma Center is Safe and Effective.

World J Surg 2019 Feb;43(2):497-503

Department of General Surgery, Kaplan Medical Center (Affiliated to the School of Medicine, Hebrew University and Hadassah, Jerusalem), 76100, Rehovot, Israel.

Background: There is debate concerning the need for specialist neurosurgical transfer of patients presenting to Level II trauma centers with a minimal head injury (Glasgow Coma Scale ≥13) and a small non-progressive intracranial bleeding (ICB).

Methods: A retrospective chart analysis was performed assessing the outcomes of adult patients presenting with a minor traumatic ICB on initial CT scan (minimal subarachnoid hemorrhage; small-width subdural hematoma without shift; punctate cerebral contusion). Patients with extradural hematomas and those patients on antiplatelet or anticoagulant therapy were excluded from the protocol. Read More

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http://link.springer.com/10.1007/s00268-018-4821-5
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http://dx.doi.org/10.1007/s00268-018-4821-5DOI Listing
February 2019
5 Reads

Changes in Posttraumatic Brain Edema in Craniectomy-Selective Brain Hypothermia Model Are Associated With Modulation of Aquaporin-4 Level.

Front Neurol 2018 2;9:799. Epub 2018 Oct 2.

Department of Neurosurgery, Faculty of Medicine, Saarland University Medical Center, Saarland University, Homburg, Germany.

Both hypothermia and decompressive craniectomy have been considered as a treatment for traumatic brain injury. In previous experiments we established a murine model of decompressive craniectomy and we presented attenuated edema formation due to focal brain cooling. Since edema development is regulated via function of water channel proteins, our hypothesis was that the effects of decompressive craniectomy and of hypothermia are associated with a change in aquaporin-4 (AQP4) concentration. Read More

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http://dx.doi.org/10.3389/fneur.2018.00799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176780PMC
October 2018
7 Reads

Central versus Local Radiological Reading of Acute Computed Tomography Characteristics in Multi-Center Traumatic Brain Injury Research.

J Neurotrauma 2019 04 11;36(7):1080-1092. Epub 2018 Dec 11.

1 Department of Radiology, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium.

Observer variability in local radiological reading is a major concern in large-scale multi-center traumatic brain injury (TBI) studies. A central review process has been advocated to minimize this variability. The aim of this study is to compare central with local reading of TBI imaging datasets and to investigate the added value of central review. Read More

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http://dx.doi.org/10.1089/neu.2018.6061DOI Listing
April 2019
24 Reads

Angiopoietin/Tie2 Axis Regulates the Age-at-Injury Cerebrovascular Response to Traumatic Brain Injury.

J Neurosci 2018 11 21;38(45):9618-9634. Epub 2018 Sep 21.

The Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine,

Although age-at-injury influences chronic recovery from traumatic brain injury (TBI), the differential effects of age on early outcome remain understudied. Using a male murine model of moderate contusion injury, we investigated the underlying mechanism(s) regulating the distinct response between juvenile and adult TBI. We demonstrate similar biomechanical and physical properties of naive juvenile and adult brains. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.0914-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222064PMC
November 2018
9 Reads

Benefit of hyperbaric oxygen therapy treatment in direct traumatic optic neuropathy: case report.

Undersea Hyperb Med 2018 Jul-Aug;45(4):463-471

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.

Direct traumatic optic neuropathy (TON) is a devastating condition and clinical challenge. Its adequate treatment remains controversial. Hyperbaric oxygen (HBO2) therapy has been proposed as an adjunctive treatment for eye disease but has rarely been used in optic neuropathy. Read More

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October 2019
1 Read

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury.

Proc Natl Acad Sci U S A 2018 09 10;115(39):E9230-E9238. Epub 2018 Sep 10.

Pittsburgh Institute of Brain Disorders and Recovery, University of Pittsburgh, Pittsburgh, PA 15213;

Recombinant tissue plasminogen activator (tPA) is a Food and Drug Administration-approved thrombolytic treatment for ischemic stroke. tPA is also naturally expressed in glial and neuronal cells of the brain, where it promotes axon outgrowth and synaptic plasticity. However, there are conflicting reports of harmful versus neuroprotective effects of tPA in acute brain injury models. Read More

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http://dx.doi.org/10.1073/pnas.1810693115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166834PMC
September 2018
7 Reads

Increases in Microvascular Perfusion and Tissue Oxygenation via Vasodilatation After Anodal Transcranial Direct Current Stimulation in the Healthy and Traumatized Mouse Brain.

Adv Exp Med Biol 2018 ;1072:27-31

Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Traumatic brain injury (TBI), causing neurological deficit in 70% of survivors, still lacks a clinically proven effective therapy. Transcranial direct current stimulation (tDCS) has emerged as a promising electroceutical therapeutic intervention possibly suitable for TBI; however, due to limited animal studies the mechanisms and optimal parameters are unknown. Using a mouse model of TBI we evaluated the acute effects of the anodal tDCS on cerebral blood flow (CBF) and tissue oxygenation, and assessed its efficacy in long-term neurologic recovery. Read More

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http://dx.doi.org/10.1007/978-3-319-91287-5_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294145PMC
January 2019
29 Reads

Temporal lobe contusions on computed tomography are associated with impaired 6-month functional recovery after mild traumatic brain injury: a TRACK-TBI study.

Neurol Res 2018 Nov 3;40(11):972-981. Epub 2018 Sep 3.

a Department of Neurological Surgery , University of California San Francisco , San Francisco , CA , USA.

Introduction: Mild traumatic brain injury (MTBI) can cause persistent functional deficits and healthcare burden. Understanding the association between intracranial contusions and outcome may aid in MTBI treatment and prognosis.

Methods: MTBI patients with Glasgow Coma Scale 13-15 and 6-month outcomes [Glasgow Outcome Scale-Extended (GOSE)], without polytrauma from the prospective TRACK-TBI Pilot study were analyzed. Read More

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http://dx.doi.org/10.1080/01616412.2018.1505416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464373PMC
November 2018
34 Reads
1.450 Impact Factor

Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion.

J Neurotrauma 2019 04 4;36(7):1060-1079. Epub 2018 Oct 4.

1 Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, Maryland.

In severe traumatic brain injury (TBI), contusions often are worsened by contusion expansion or hemorrhagic progression of contusion (HPC), which may double the original contusion volume and worsen outcome. In humans and rodents with contusion-TBI, sulfonylurea receptor 1 (SUR1) is upregulated in microvessels and astrocytes, and in rodent models, blockade of SUR1 with glibenclamide reduces HPC. SUR1 does not function by itself, but must co-assemble with either KIR6. Read More

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https://www.liebertpub.com/doi/10.1089/neu.2018.5986
Publisher Site
http://dx.doi.org/10.1089/neu.2018.5986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446209PMC
April 2019
27 Reads

Unusual, Acute, and Delayed Traumatic Torcular Herophili Epidural Hematoma Causing Malignant Encephalocele During Surgery: A Case Report.

Am J Case Rep 2018 Aug 29;19:1030-1034. Epub 2018 Aug 29.

Department of Neurosurgery, Huishan People's Hospital of Wuxi, Wuxi, Jiangsu, China (mainland).

BACKGROUND Traumatic torcular herophili epidural hematoma is a rare and specific type of traumatic brain injury that is technically difficult to treat and, more critically, can lead to malignant encephalocele during the operation. CASE REPORT A 40-year-old man presented to our hospital 2 h after a motor vehicle crash. Emergency cranial CT showed a frontotemporal subdural hematoma; 3 h after the patient was admitted, the GCS score decreased to 8 and cranial CT re-examination showed that the frontotemporal subdural hematoma was significantly larger than before. Read More

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https://www.amjcaserep.com/abstract/index/idArt/910030
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http://dx.doi.org/10.12659/AJCR.910030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124356PMC
August 2018
43 Reads

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol.

Neurobiol Dis 2019 03 23;123:110-114. Epub 2018 Jul 23.

David Geffen School of Medicine at UCLA, United States.

The Epilepsy Bioinformatics Study for Anti-epileptogenic Therapy (EpiBioS4Rx) is a longitudinal prospective observational study funded by the National Institute of Health (NIH) to discover and validate observational biomarkers of epileptogenesis after traumatic brain injury (TBI). A multidisciplinary approach has been incorporated to investigate acute electrical, neuroanatomical, and blood biomarkers after TBI that may predict the development of post-traumatic epilepsy (PTE). We plan to enroll 300 moderate-severe TBI patients with a frontal and/or temporal lobe hemorrhagic contusion. Read More

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http://dx.doi.org/10.1016/j.nbd.2018.07.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344322PMC
March 2019
17 Reads

What Is the Best Timing of Repeated CT Scan in Mild Head Trauma with an Initially Positive CT Scan?

World Neurosurg 2018 Oct 30;118:e316-e322. Epub 2018 Jun 30.

Department of Neurosurgery, Chieti University G. D'Annunzio, Santo Spirito Hospital, Pescara, Italy.

Background: Mild traumatic brain injury (MTBI) is among the most common causes of emergency admission. Current guidelines have clearly evidenced risk factors and neurologic signs that should suggest computed tomography (CT) of the head at admission and indications for the first repeated CT scan. However, the role and frequency of further repeated CT scans after an initially positive scan are still unclear. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.185DOI Listing
October 2018
7 Reads

Establishment of a precise novel brain trauma model in a large animal based on injury of the cerebral motor cortex.

J Neurosci Methods 2018 09 28;307:95-105. Epub 2018 Jun 28.

Institution of Brain Trauma and Neurology Disease, Key laboratory of neurotrauma repair of Tianjin, Affiliated Hospital of Logistics University of PAP, Chenglin Road No.220, Tianjin 300162, China. Electronic address:

Background: Animal models are essential in simulating clinical diseases and facilitating relevant studies.

New Method: We established a precise canine model of traumatic brain injury (TBI) based on cerebral motor cortex injury which was confirmed by neuroimaging, electrophysiology, and a series of motor function assessment methods. Twelve beagles were divided into control, sham, and model groups. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2018.06.025DOI Listing
September 2018
50 Reads