725 results match your criteria Brain Contusion Imaging

Cerebrovascular diseases in two patients with entire NSD1 deletion.

Hum Genome Var 2021 May 24;8(1):20. Epub 2021 May 24.

Department of human genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.

We describe two patients with NSD1 deletion, who presented with early-onset, or recurrent cerebrovascular diseases (CVDs). A 39-year-old female showed developmental delay and abnormal gait in infancy, and developed slowly-progressive intellectual disability and movement disorders. Brain imaging suggested recurrent parenchymal hemorrhages. Read More

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Combined brain and thoracic trauma surgery in a hybrid emergency room system: a case report.

BMC Surg 2021 Apr 27;21(1):219. Epub 2021 Apr 27.

Department of Emergency and Critical Care Medicine, Kansai Medical University Hospital, 2-3-1 Shinmachi, Hirakata, Osaka, 573-1191, Japan.

Background: A novel trauma workflow system called the hybrid emergency room (Hybrid ER), which combines a sliding CT scanner system with interventional radiology features (IVR-CT), was initially instituted in our emergency department in 2011. Use of the Hybrid ER enables CT diagnosis and emergency therapeutic interventions without transferring the patient to another room. We describe an illustrative case of severe multiple blunt trauma that included injuries to the brain and torso to highlight the ability to perform multiple procedures in the Hybrid ER. Read More

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Magnetic Resonance Imaging Findings Are Associated with Long-Term Global Neurological Function or Death after Traumatic Brain Injury in Critically Ill Children.

J Neurotrauma 2021 May 13. Epub 2021 May 13.

Neuroscience and Mental Health Research Program, Hospital for Sick Children, Toronto, Ontario, Canada.

The identification of children with traumatic brain injury (TBI) who are at risk of death or poor global neurological functional outcome remains a challenge. Magnetic resonance imaging (MRI) can detect several brain pathologies that are a result of TBI; however, the types and locations of pathology that are the most predictive remain to be determined. Forty-two critically ill children with TBI were recruited prospectively from pediatric intensive care units at five Canadian children's hospitals. Read More

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[Diagnosing Status Epilepticus].

Masafumi Fukuda

No Shinkei Geka 2021 Mar;49(2):335-341

Department of Functional Neurosurgery, NHO Nishiniigata Chuo Hospital.

Both diffusion-weighted MRI(DWI)modalities and continuous electroencephalography(cEEG)are useful for diagnosing status epilepticus. In case 1, DWI showed hyperintense regions in the right-sided parieto-occipital cortex during peri-ictal status. Intensity of the regions normalized after left hemiparesis improved. Read More

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[Efficacy and safety of intraoperative ultrasound-assisted neuroendoscopy in the treatment of hypertensive intracerebral hemorrhage via transsylvian approach].

Zhonghua Yi Xue Za Zhi 2021 Mar;101(9):620-623

Emergency Department, the Affiliated Wuxi No.2 Hospital of Nanjing Medical University, Wuxi 214002, China.

To explore the efficacy and safety of intraoperative ultrasound-assisted neuroendoscopy for treating hypertensive intracerebral hemorrhage (HICH) via lateral fissure and insula approach. The clinical data of 66 patients with HICH in basal ganglia who underwent intraoperative ultrasound-assisted neuroendoscopy via lateral fissure and insula approach for hematoma evacuation were retrospectively analyzed, including operative data and follow-up results. All patients had no brain hernia before operation. Read More

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Parenchymal brain injuries in abusive head trauma.

Pediatr Radiol 2021 May 27;51(6):898-910. Epub 2021 Feb 27.

Department of Radiology, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, UK.

The consequences of abusive head trauma (AHT) can be devastating for both the individual child and for wider society. Death is undoubtedly a very real possibility, but even for those children who survive, there is often very significant morbidity with the potential for gross motor and cognitive impairment, behavioural problems, blindness and epilepsy, which can greatly affect their quality of life. Caring for such children places a vast financial and infrastructural burden on society that frequently extends well into adulthood. Read More

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Relationships between spinal cord blood flow measured with flow-sensitive alternating inversion recovery (FAIR) and neurobehavioral outcomes in rat spinal cord injury.

Magn Reson Imaging 2021 05 6;78:42-51. Epub 2021 Feb 6.

Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States of America; Clement J. Zablocki Veterans Affairs Medical Center, Milwaukee, WI, United States of America.

In the traumatically injured spinal cord, decreased perfusion is believed to contribute to secondary tissue damage beyond the primary mechanical impact, and restoration of perfusion is believed to be a promising therapeutic target. However, methods to monitor spinal cord perfusion non-invasively are limited. Perfusion magnetic resonance imaging (MRI) techniques established for the brain have not been routinely adopted to the spinal cord. Read More

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Traumatic brain injury in children: 18 years of management.

Pan Afr Med J 2020 13;37:235. Epub 2020 Nov 13.

Neurosurgery Department, University Hospital Center of Yopougon, Abidjan, Ivory Coast.

Traumatic brain injury in children is a common cause of emergency department admission to our institution. The aim was to summarize the management of all head injuries in children. This was a retrospective, descriptive single center study performed in the Neurosurgery Department, University Hospital Center, Yopougon-Abidjan, Ivory Coast from January 2000 to December 2017. Read More

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Risk factors for positive brain CT scan in children with traumatic brain injury and GCS = 15: A retrospective study.

Medicine (Baltimore) 2021 Jan;100(4):e24543

Department of Neurosurgery, Taizhou Central Hospital, Jiaojiang, China.

Abstract: It is controversial whether it is necessary to carry out head computed tomography (CT) examination for children who had a traumatic brain injury (TBI) but are conscious (Glasgow Coma Scale (GCS) = 15). The present study explored the risk/predictive factors of positive CT results in children with mild closed head injury and GCS = 15.This was a retrospective study of children (0-18 years of age) with TBI and GCS = 15 and treated at the First People's Hospital of Wenling between 06/2013 and 06/2018. Read More

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January 2021

Bloodletting Puncture at Hand Twelve Jing-Well Points Relieves Brain Edema after Severe Traumatic Brain Injury in Rats via Inhibiting MAPK Signaling Pathway.

Chin J Integr Med 2021 Apr 30;27(4):291-299. Epub 2021 Jan 30.

Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

Objective: To investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI) and the potential molecular signaling pathways.

Methods: Adult male Sprague-Dawley rats were assigned to the sham-operated (sham), TBI, and bloodletting puncture (bloodletting) groups (n=24 per group) using a randomized number table. The TBI model rats were induced by cortical contusion and then bloodletting puncture were performed at HTWP twice a day for 2 days. Read More

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Posttraumatic Delayed Jugular Foramen Syndrome in a Toddler.

Neuropediatrics 2021 Jan 28. Epub 2021 Jan 28.

Pediatric Neurology Unit, Department of Pediatrics, Navarra Health Service Hospital, Pamplona, Spain.

Background:  Multiple lower cranial nerve palsies have been attributed to occipital condyle fractures in older children and adults, but no clinical details of other possible mechanisms have been described in infants.

Case Report:  A 33-month-old boy suffered blunt head trauma. A bilateral skull base fracture was diagnosed, with favorable outcome during the first days after trauma. Read More

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January 2021

Cerebral trauma-induced dyschromatopsia in the left hemifield: case presentation.

BMC Ophthalmol 2021 Jan 27;21(1):63. Epub 2021 Jan 27.

Department of Ophthalmology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan.

Background: Acquired color anomalies caused by cerebral trauma are classified as either achromatopsias or dyschromatopsias (Zeki, Brain 113:1721-1777, 1990). The three main brain regions stimulated by color are V1, the lingual gyrus, which was designated as human V4 (hV4), and the fusiform gyrus, designated as V4α. (Zeki, Brain 113:1721-1777, 1990). Read More

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January 2021

Original experimental rat model of blast-induced mild traumatic brain injury: a pilot study.

Brain Inj 2021 Feb 16;35(3):368-381. Epub 2021 Jan 16.

Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Objective: Diagnosing blast-induced mild traumatic brain injury (mTBI) is difficult due to minimal imaging findings. This study aimed to establish a rat model of behavioral abnormality caused by blast-induced mTBI and detect new findings for therapeutic intervention.

Methods: We used a bench-top blast wave generator with the blast wave exiting through a 20-mm I. Read More

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February 2021

Neurotropin exerts neuroprotective effects after spinal cord injury by inhibiting apoptosis and modulating cytokines.

J Orthop Translat 2021 Jan 23;26:74-83. Epub 2020 Mar 23.

Tianjin Key Laboratory of Spine and Spinal Cord, International Science and Technology Cooperation Base of Spinal Cord Injury, ICMRS Collaborating Center for Spinal Cord Injury, Department of Orthopaedics, Tianjin Medical University General Hospital, Tianjin, China.

Background/objective: Spinal cord injury (SCI) severely and irreversibly damages the central nervous system. Neurotropin (NTP), a nonprotein extract obtained from inflamed rabbit skin inoculated with vaccinia virus, is a drug that has been used for more than sixty years to alleviate neuropathic pain. It also reportedly exerts a neuroprotective role in peripheral nerves and in response to various central nervous system diseases, such as brain injury and Alzheimer disease. Read More

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January 2021

Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study.

J Neurotrauma 2021 Jun 18;38(12):1620-1631. Epub 2021 Feb 18.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

Diffusion tractography magnetic resonance imaging (MRI) can infer changes in network connectivity in patients with traumatic brain injury (TBI), but the pathological substrates of disconnected tracts have not been well defined because of a lack of high-resolution imaging with histopathological validation. We developed an MRI protocol to analyze tract terminations at 750-μm isotropic resolution, followed by histopathological evaluation of white matter pathology, and applied these methods to a 60-year-old man who died 26 days after TBI. Analysis of 74 cerebral hemispheric white matter regions revealed a heterogeneous distribution of tract disruptions. Read More

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Effect of tranexamic acid on intracranial haemorrhage and infarction in patients with traumatic brain injury: a pre-planned substudy in a sample of CRASH-3 trial patients.

Emerg Med J 2020 Dec 1. Epub 2020 Dec 1.

Clinical Trials Unit, London School of Hygiene & Tropical Medicine Faculty of Epidemiology and Population Health, London, UK.

Background: Early tranexamic acid (TXA) treatment reduces head injury deaths after traumatic brain injury (TBI). We used brain scans that were acquired as part of the routine clinical practice during the CRASH-3 trial (before unblinding) to examine the mechanism of action of TXA in TBI. Specifically, we explored the potential effects of TXA on intracranial haemorrhage and infarction. Read More

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December 2020

Computer-Assisted Measurement of Traumatic Brain Hemorrhage Volume Is More Predictive of Functional Outcome and Mortality than Standard ABC/2 Method: An Analysis of Computed Tomography Imaging Data from the Progesterone for Traumatic Brain Injury Experimental Clinical Treatment Phase-III Trial.

J Neurotrauma 2021 Mar 8;38(5):604-615. Epub 2021 Jan 8.

Department of Diagnostic Imaging, and Warren Alpert Medical School of Brown University, Providence Rhode Island, USA.

Hemorrhage volume is an important variable in emergently assessing traumatic brain injury (TBI). The most widely used method for rapid volume estimation is ABC/2, a simple algorithm that approximates lesion geometry as perfectly ellipsoid. The relative prognostic value of volume measurement based on more precise hematoma topology remains unknown. Read More

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Evaluation of Diffusion Tensor Imaging and Fluid Based Biomarkers in a Large Animal Trial of Cyclosporine in Focal Traumatic Brain Injury.

J Neurotrauma 2021 Jan 25. Epub 2021 Jan 25.

Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, USA.

All phase III trials evaluating medical treatments for traumatic brain injury (TBI), performed to date, have failed. To facilitate future success there is a need for novel outcome metrics that can bridge pre-clinical studies to clinical proof of concept trials. Our objective was to assess diffusion tensor imaging (DTI) and biofluid-based biomarkers as efficacy outcome metrics in a large animal study evaluating the efficacy of cyclosporine in TBI. Read More

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January 2021

Growing Skull Fracture in the Primary Motor Cortex in a 50-day-old Child: A Case Report.

Inkyeong Kim

Korean J Neurotrauma 2020 Oct 26;16(2):278-283. Epub 2020 Oct 26.

Department of Neurosurgery, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.

Growing skull fracture (GSF) is a rare complication of skull fracture in children. We report a case of GSF, also known as leptomeningeal cyst with significant damage in the motor cortex in a 50-day-old child, but the motor function was preserved. A 50-day-old male baby visited our hospital after trauma in the left side of the head. Read More

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October 2020

Early Head Computed Tomography Abnormalities Associated with Elevated Intracranial Pressure in Severe Traumatic Brain Injury.

J Neuroimaging 2021 01 4;31(1):199-208. Epub 2020 Nov 4.

Department of Neurology, Stanford University, Stanford, CA.

Background And Purpose: Intracranial pressure (ICP) monitoring is recommended in severe traumatic brain injury (sTBI), yet invasive monitoring has risks, and many patients do not develop elevated ICP. Tools to identify patients at risk for ICP elevation are limited. We aimed to identify early radiologic biomarkers of ICP elevation. Read More

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January 2021

A verified period of normal neurologic status in a young victim of abusive head trauma.

J Forensic Leg Med 2020 Aug 18;74:102024. Epub 2020 Jul 18.

Children's Mercy Hospital, Kansas City, MO, United States. Electronic address:

Abusive head trauma (AHT) is the leading cause of child physical abuse fatalities, and survivors frequently face life-long consequences. Victims of AHT are typically infants, and many are subjected to repeat AHT if not accurately identified and protected. Identifying the timing of AHT is often a medical-forensic process, and investigative personnel use the determination of timing of AHT to guide safety decisions for the child victim. Read More

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Longitudinal Characterization of Blood-Brain Barrier Permeability after Experimental Traumatic Brain Injury by 2-Photon Microscopy.

J Neurotrauma 2021 02 30;38(4):399-410. Epub 2020 Oct 30.

Institute for Stroke and Dementia Research (ISD) and Ludwig-Maximilians-University (LMU) Munich Medical Center, Munich, Germany.

Vasogenic brain edema (VBE) formation remains an important factor determining the fate of patients with traumatic brain injury (TBI). The spatial and temporal development of VBE, however, remains poorly understood because of the lack of sufficiently sensitive measurement techniques. To close this knowledge gap, we directly visualized the full time course of vascular leakage after TBI by 2-photon microscopy (2-PM). Read More

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February 2021

Effects of Preexisting Diabetes Mellitus on the Severity of Traumatic Brain Injury.

J Neurotrauma 2021 Apr 18;38(7):886-902. Epub 2020 Nov 18.

Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.

Falls and traffic accidents can cause traumatic brain injury (TBI). Assessment of the injury severity is essential to determine the prognosis or the cause of death. Diabetes mellitus (DM) is a common preexisting disease in elderly adults. Read More

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Missed Skeletal Trauma Detected by Whole Body Bone Scan in Patients with Traumatic Brain Injury.

J Korean Neurosurg Soc 2020 Sep 1;63(5):649-656. Epub 2020 Sep 1.

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Objective: Unclear mental state is one of the major factors contributing to diagnostic failure of occult skeletal trauma in patients with traumatic brain injury (TBI). The aim of this study was to evaluate the overlooked co-occurring skeletal trauma through whole body bone scan (WBBS) in TBI.

Methods: A retrospective study of 547 TBI patients admitted between 2015 and 2017 was performed to investigate their cooccurring skeletal injuries detected by WBBS. Read More

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September 2020

Early brain biomarkers of post-traumatic seizures: initial report of the multicentre epilepsy bioinformatics study for antiepileptogenic therapy (EpiBioS4Rx) prospective study.

J Neurol Neurosurg Psychiatry 2020 11 26;91(11):1154-1157. Epub 2020 Aug 26.

Psychology, University of California Los Angeles, Los Angeles, California, USA

Background: Traumatic brain injury (TBI) causes early seizures and is the leading cause of post-traumatic epilepsy. We prospectively assessed structural imaging biomarkers differentiating patients who develop seizures secondary to TBI from patients who do not.

Design: Multicentre prospective cohort study starting in 2018. Read More

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November 2020

Risk Factors and Outcomes Associated with Blunt Cerebrovascular Injury in Patients with Mild or Moderate Traumatic Brain Injury.

Ann Vasc Surg 2021 Feb 5;71:157-166. Epub 2020 Aug 5.

Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY.

Background: Blunt cerebrovascular injury (BCVI) represents a spectrum of traumatic injuries to the carotid and vertebral arteries that is an often-overlooked source of morbidity and mortality. Its incidence, risk factors, and effect on outcomes in patients with mild or moderate traumatic brain injury (mTBI) have not been studied independently.

Methods: The National Trauma Data Bank from 2013 to 2017 was queried to identify patients with mTBI who suffered blunt injuries. Read More

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February 2021

Optimizing the accuracy of cortical volumetric analysis in traumatic brain injury.

MethodsX 2020 11;7:100994. Epub 2020 Jul 11.

Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Cortical volumetric analysis is widely used to study the anatomic basis of neurological deficits in patients with traumatic brain injury (TBI). However, patients with TBI-related lesions are often excluded from MRI analyses because cortical lesions may compromise the accuracy of reconstructed surfaces upon which volumetric measurements are based. We developed a FreeSurfer-based lesion correction method and tested its impact on cortical volume measures in 87 patients with chronic moderate-to-severe TBI. Read More

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Human dental stem cells of the apical papilla associated to BDNF-loaded pharmacologically active microcarriers (PAMs) enhance locomotor function after spinal cord injury.

Int J Pharm 2020 Sep 23;587:119685. Epub 2020 Jul 23.

Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Université Catholique de Louvain, UCLouvain, 1200 Bruxelles, Belgium. Electronic address:

There is no treatment for spinal cord injury (SCI) that fully repairs the damages. One strategy is to inject mesenchymal stem cells around the lesion to benefit from their immunomodulatory properties and neuroprotective effect. Our hypothesis was that the combination of dental stem cells from the apical papilla (SCAP) with pharmacologically active microcarriers (PAMs) releasing brain-derived neurotrophic factor (BDNF) would improve rat locomotor function by immunomodulation and neuroprotection. Read More

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September 2020

Guillain-Barre Syndrome After Craniocerebral Gunshot Injury: First Report.

World Neurosurg 2020 11 22;143:23-25. Epub 2020 Jul 22.

Department of Neurosurgery, University of Health Sciences Izmir Bozyaka Education and Research Hospital, Izmir, Turkey.

Background: Guillain-Barre syndrome (GBS) is a rare but serious disorder involving peripheral nerve inflammatory demyelination characterized by acute onset tetraparesis and areflexia. Generally, GBS is preceded by a bacterial or viral infection, and post-traumatic or postsurgical GBS is rarely seen.

Case Description: A 41-year-old man with severe craniocerebral gunshot injury and open depressed occipital bone fracture was operated urgently. Read More

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November 2020

Use of diffusion tensor imaging to assess the vasogenic edema in traumatic pericontusional tissue.

Neurocirugia (Astur : Engl Ed) 2020 Jul 21. Epub 2020 Jul 21.

Intensive Care Department, Son Espases University Hospital, Palma de Mallorca, Spain. Electronic address:

Background And Objective: Cerebral edema is a frequent and serious complication of traumatic brain injury (TBI). Diffusion tensor imaging (DTI) is considered a useful technique to assess white matter integrity after TBI. The objective of this prospective, observational study was to assess the characteristics of the vasogenic edema in the traumatic pericontusional tissue and compare it to the vasogenic edema found in brain tumors. Read More

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