772 results match your criteria Brain Contusion Imaging

Poly d,l-(lactic-co-glycolic) Acid PEGylated Isoliquiritigenin Alleviates Traumatic Brain Injury by Reversing Cyclooxygenase 2 Level.

J Biomed Nanotechnol 2022 Mar;18(3):909-916

Department of Radiology, Cangzhou Central Hospital, No. 16 Xinhua West Road, Cangzhou, 061001, Hebei, China.

As a severe neurological disease of trauma, traumatic brain injury (TBI) leads to other disorders, such as depression, dementia and epilepsy. This study investigated whether poly d,l-(lactic-co-glycolic) acid (PLGA) PEGylated isoliquiritigenin could alleviate TBI. One hundred and eighty-three patients with clinical brain trauma were divided into two groups with or without intracranial injury in magnetic resonance imaging. Read More

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A novel decision support tool (IniCT score) for repeat head computed tomography in pediatric mild traumatic brain injury.

World Neurosurg 2022 May 30. Epub 2022 May 30.

Department of Neurosurgery, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Background: Necessity of computed tomography (CT) has been questioned in pediatric mTBI due to concerns related to radiation exposure. Distinguishing patients with lower and higher risk of clinically important TBI (ciTBI) is paramount to the optimal management of these patients.

Objective: This study aimed to analyze the imaging predictors of ciTBI, and develop an algorithm to identify patients at low and high risk for ciTBI to inform clinical decision-making using a large single-center cohort of pediatric mTBI patients. Read More

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Transcranial Doppler in a child: A most valuable imaging modality.

Ultrasound 2022 May 17;30(2):167-172. Epub 2021 Mar 17.

Department of Anesthesia and Intensive Care, Academic Hospital of Udine, Udine, Italy.

Introduction: Pediatric brain injury is a common cause of emergency department (ED) referral. Although severe traumatic brain damage is less frequent, it could be primarily managed by non-pediatric critical care physicians called in for advice. Clinical evaluation is important, but radiology is of particular value in the case of severe brain injury. Read More

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Imaging in paediatric blast injuries: musculoskeletal injuries in the Syrian Civil War.

Clin Radiol 2022 Jul 22;77(7):522-528. Epub 2022 Apr 22.

Department of Biostatistics, Faculty of Medicine, Hatay Mustafa Kemal University, Antakya, Hatay Province, Turkey.

Aim: To examine the radiological images of children with musculoskeletal injuries and accompanying organ injuries caused by explosions to determine the differences and frequency of injury types and to emphasise the importance of radiology in war injuries.

Materials And Methods: Seventy-four children with injuries caused by bomb explosions were included in the study. The paediatric trauma scores evaluated in the emergency department on the first admission were recorded. Read More

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Suppression of Aquaporin-4 By Antisense Oligonucleotides Reduces Brain Edema In Experimental Traumatic Brain Injury.

Turk Neurosurg 2021 Oct 21. Epub 2021 Oct 21.

American Hospital, Department of Neurosurgery, Istanbul, Turkey.

Aim: In this study, suppression of Aquaporin-4 (AQP4) synthesis via intracerebroventricular (i.c.v. Read More

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October 2021

Concurrent cranial and cervical spine injuries by associated injury mechanisms in traumatic brain injury patients.

SA J Radiol 2022 24;26(1):2321. Epub 2022 Mar 24.

Trauma Service and Trauma ICU, Inkosi Albert Luthuli Central Hospital, Durban, South Africa.

Background: The incidence of concurrent traumatic brain injury (TBI) and cervical spine injury (c-spine) is relatively high, with a variety of risk factors.

Objectives: The purpose of this study was to determine the incidence and related factors associated with combined cranial and c-spine injury in TBI patients by assessing their demographics and clinical profiles.

Method: A retrospective study of patients attending the Trauma Centre at the Inkosi Albert Luthuli Hospital as post head trauma emergencies and their CT brain and c-spine imaging performed between January 2018 and December 2018. Read More

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Association of frontal and maxillary bone fractures and concomitant craniocerebral injuries in patients presenting with head trauma.

Niger J Clin Pract 2022 Mar;25(3):342-348

Department of Radiology, Alaaddin Keykubat University, School of Medicine, Alanya, Antalya, Turkey.

Background: Maxillofacial fractures and craniocerebral injuries are common in patients with head trauma. These are injuries with high mortality and morbidity. Therefore, patients with head trauma should be evaluated early with a multidisciplinary approach. Read More

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Rosai-Dorfman disease mimicking subdural hematoma: a case report.

J Int Med Res 2022 Mar;50(3):3000605221083750

Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Rosia-Dorfman disease (RDD) is a rare benign disease with exceedingly rare neural involvement. In this report, we describe a very rare case of intracranial RDD mimicking a subdural hematoma. The patient presented with headache and a suspected history of head injury. Read More

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Human induced pluripotent stem cells integrate, create synapses and extend long axons after spinal cord injury.

J Cell Mol Med 2022 04 8;26(7):1932-1942. Epub 2022 Mar 8.

Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA.

Numerous interventions have been explored in animal models using cells differentiated from human induced pluripotent stem cells (iPSCs) in the context of neural injury with some success. Our work seeks to transplant cells that are generated from hiPSCs into regionally specific spinal neural progenitor cells (sNPCs) utilizing a novel accelerated differentiation protocol designed for clinical translation. We chose a xenotransplantation model because our laboratory is focused on the behaviour of human cells in order to bring this potential therapy to translation. Read More

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Usage of image registration and three-dimensional visualization tools on serial computed tomography for the analysis of patients with traumatic intraparenchymal hemorrhages.

J Clin Neurosci 2022 Apr 16;98:154-161. Epub 2022 Feb 16.

Department of Radiological Sciences, University of California, Irvine, CA, USA; Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan.

The aim of this study was to apply registration and three-dimensional (3D) display tools to assess the evolution of intraparenchymal hemorrhage (IPH) in patients with traumatic brain injury (TBI). We identified 109 TBI patients who had two computed tomography (CT) scans within 4 days retrospectively. The IPH was manually outlined. Read More

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Relationship Between CT Head Findings and Long-term Recovery in Children with Complicated Mild Traumatic Brain Injury.

Brain Inj 2022 01 7;36(1):77-86. Epub 2022 Feb 7.

Department of Physical Medicine & Rehabilitation, University of Utah, Salt Lake City, Utah, USA.

Primary Objective: Complicated mild traumatic brain injury (C-mTBI) refers to CT positive patients with clinically mild TBI. This study investigates the association between CT head findings at time of injury and recovery of paediatric patients with C-mTBI.

Research Design: Retrospective survey and chart review. Read More

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January 2022

Persistent Air Embolism after Blunt Chest Trauma with Recovery to Pre-Existing Consciousness Level: A Case Report and Literature Review.

Neurotrauma Rep 2022 20;3(1):38-43. Epub 2022 Jan 20.

Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, Tokyo, Japan.

We report the case of a 71-year-old woman in whom cerebral air embolism resulted from blunt chest trauma. The woman had been lying on her left side for a while after the injury, and air traveled to the right side of the brain. As a result, a cerebral infarction occurred in the right cerebral hemisphere that caused loss of consciousness for more than 40 days. Read More

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January 2022

Postoperative magnetic resonance imaging may predict poor outcome in children with severe traumatic brain injuries who undergo cranial surgery.

J Neurosurg Pediatr 2022 Jan 21:1-5. Epub 2022 Jan 21.

Objective: Multiple studies have evaluated the use of MRI for prognostication in pediatric patients with severe traumatic brain injury (TBI) and have found a correlation between diffuse axonal injury (DAI)-type lesions and outcome. However, there remains a limited understanding about the use of MRI for prognostication after severe TBI in children who have undergone cranial surgery.

Methods: Children with severe TBI who underwent craniectomy or craniotomy at Primary Children's Hospital in Salt Lake City, Utah, between 2010 and 2019 were identified retrospectively. Read More

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January 2022

Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx).

Brain Imaging Behav 2021 Dec 5;15(6):2804-2812. Epub 2022 Jan 5.

Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.

Traumatic brain injury (TBI) can produce heterogeneous injury patterns including a variety of hemorrhagic and non-hemorrhagic lesions. The impact of lesion size, location, and interaction between total number and location of contusions may influence the occurrence of seizures after TBI. We report our methodologic approach to this question in this preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). Read More

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December 2021

Traumatic brain injury and intraparenchymal hemorrhage progression: Blood pressure variability matters.

Am J Emerg Med 2022 Feb 9;52:119-127. Epub 2021 Dec 9.

Research Associate Program in Emergency Medicine & Critical Care, Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA; The R. Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, USA; Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address:

Introduction: Blood pressure variability (BPV) has been shown to correlate with intraparenchymal hematoma progression (HP) and worse outcomes in patients with spontaneous intracerebral hemorrhage (sICH). However, this association has not been elucidated in patients with traumatic intraparenchymal hemorrhage or contusion (tIPH). We hypothesized that 24 h-BPV from time of admission is associated with hemorrhagic progression of contusion or intraparenchymal hemorrhage (HPC), and worse outcomes in patients with tIPH. Read More

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February 2022

Epilepsy Due to Mild TBI in Children: An Experience at a Tertiary Referral Center.

J Clin Med 2021 Dec 3;10(23). Epub 2021 Dec 3.

Comprehensive Epilepsy Center, NYU Langone Health, NYU School of Medicine, New York, NY 10016, USA.

Rationale: Posttraumatic epilepsy (PTE) is a common cause of morbidity in children after a traumatic brain injury (TBI), occurring in 10-20% of children following severe TBI. PTE is diagnosed after two or more unprovoked seizures occurring 1-week post TBI. More often, studies have focused on children with epilepsy due to severe TBI. Read More

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December 2021

Establishment and validation of a prediction model for intraparenchymal hematoma expansion in patients with cerebral contusion: A reliable Nomogram.

Clin Neurol Neurosurg 2022 01 29;212:107079. Epub 2021 Nov 29.

Department of Neurosurgery,Qinghai Provincial People's Hospital, Xining, Qinghai 810007, China. Electronic address:

Background And Objective: Cerebral Contusion (CC) is one of the most serious injury types in patients with traumatic brain injury (TBI). Traumatic intraparenchymal hematoma (TICH) expansion severely affects the patient's prognosis. In this study, the baseline data, imaging features, and laboratory examinations of patients with CC were summarized and analyzed to develop and validate a nomogram predictive model assessing the risk factors for TICH expansion. Read More

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January 2022

A Clinical Predictive Nomogram for Traumatic Brain Parenchyma Hematoma Progression.

Neurol Ther 2022 Mar 2;11(1):185-203. Epub 2021 Dec 2.

Department of Microbiology and Immunology, Guangdong Provincial Key Laboratory of Infectious Disease and Molecular Immunopathology, Shantou University Medical College, 22 Xinling Road, Shantou, 515041, Guangdong, China.

Introduction: Acute traumatic intraparenchymal hematoma (tICH) expansion is a major cause of clinical deterioration after brain contusion. Here, an accurate prediction tool for acute tICH expansion is proposed.

Methods: A multicenter hospital-based study for multivariable prediction model was conducted among patients (889 patients in a development dataset and 264 individuals in an external validation dataset) with initial and follow-up computed tomography (CT) imaging for tICH volume evaluation. Read More

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Establishment and validation of prognosis model for patients with cerebral contusion.

BMC Neurol 2021 Nov 29;21(1):463. Epub 2021 Nov 29.

Department of Neurosurgery, Qinghai Provincial People's Hospital, Xining, 810007, Qinghai, China.

Background And Objective: Cerebral Contusion (CC) is one of the most serious injury types in patients with traumatic brain injury (TBI). In this study, the baseline data, imaging features and laboratory examinations of patients with CC were summarized and analyzed to develop and validate a prediction model of nomogram to evaluate the clinical outcomes of patients.

Methods: A total of 426 patients with cerebral contusion (CC) admitted to the People's Hospital of Qinghai Province and Affiliated Hospital of Qingdao University from January 2018 to January 2021 were included in this study, We randomly divided the cohort into a training cohort (n = 284) and a validation cohort (n = 142) with a ratio of 2:1. Read More

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November 2021

Traumatic retroclival epidural hematoma associated with reversible ipsilateral internal carotid artery stenosis.

Childs Nerv Syst 2022 02 27;38(2):485-489. Epub 2021 Nov 27.

Department of Neurosurgery, Kanazawa Medical University, 1-1 Daigaku, Ucninada-machi, Kahoku, Ishikawa, 920-0293, Japan.

Introduction: Traumatic retroclival epidural hematoma is rare. It is more common in pediatrics than in adults. Although it has been known that these cases are frequently associated with abducens nerve palsy, internal carotid artery stenosis is rarely found with those hematomas. Read More

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February 2022

Do neurosurgeons follow the guidelines? A world-based survey on severe traumatic brain injury.

J Neurosurg Sci 2021 10;65(5):465-473

Department of Clinical Medicine, Faculty of Medicine, Human and Health Sciences, Macquarie University, Sydney, Australia.

Background: Traumatic brain injury (TBI) is going to be the third-leading cause of death worldwide, according to the WHO. Two European surveys suggested that adherence to brain trauma guidelines is poor. No study has compared compliance between low- (LMICs) and high-income (UHICs) countries. Read More

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October 2021

What is the impact of vasospasm on traumatic subarachnoid hemorrhage: Two cases of report.

Trauma Case Rep 2021 Dec 16;36:100543. Epub 2021 Oct 16.

Department of Neurosurgery, Teikyo University Mizonokuchi Hospital, 5-1-1 Futago, Takatsu-ku, Kawasaki, Kanagawa 213-8507, Japan.

It is difficult to predict that vasospasm would occur in traumatic subarachnoid hemorrhage (SAH) patients. Younger age, a lower score of Glasgow coma scale (GCS≦8) on admission, and greater cisternal blood volume are considered to correlate with post-traumatic vasospasm. We present two cases of traumatic SAH with post-traumatic vasospasm; one was a 74-year-old man and the other was a 72-year-old woman. Read More

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December 2021

Cerebral Microbleeds May Be Less Detectable by Susceptibility Weighted Imaging MRI From 24 to 72 Hours After Traumatic Brain Injury.

Front Neurosci 2021 30;15:711074. Epub 2021 Sep 30.

Department of Medical Imaging, Medical School, University of Pécs, Pécs, Hungary.

A former rodent study showed that cerebral traumatic microbleeds (TMBs) may temporarily become invisible shortly after injury when detected by susceptibility weighted imaging (SWI). The present study aims to validate this phenomenon in human SWI. In this retrospective study, 46 traumatic brain injury (TBI) patients in various forms of severity were included and willingly complied with our strict selection criteria. Read More

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September 2021

Reconstruction for diverse fronto-orbital defects with computer-assisted designed and computer-assisted manufactured PEEK implants in one-stage operation: Case reports.

Medicine (Baltimore) 2021 Oct;100(40):e27452

Department of Neurosurgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Rational: Reconstruction of complex craniofacial defects in fronto-orbital region has been reported to be extremely few. In this study, we report 2 cases with fronto-orbital defects of different etiologies in one-stage surgical reconstruction with polyetheretherketone (PEEK) prosthesis using computer-assisted design and computer-assisted manufactured (CAD-CAM) techniques.

Patient Concerns: One patient was a 49-year-old man, who admitted with a depressed and comminuted fracture in the left fronto-orbital region as a result of a motor vehicle collision. Read More

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October 2021

Cerebellar mutism following head trauma: A case report and literature review.

Surg Neurol Int 2021 6;12:446. Epub 2021 Sep 6.

Department of Neurosurgery, Beneficencia Portuguesa de Sao Paulo, Sao Paulo, Brazil.

Background: Cerebellar mutism (CM) is defined as the lack of speech production, despite an intact state of consciousness and cognitive function, that happens secondary to a cerebellar insult. To the best of our knowledge, only five cases have thus far been described in the English literature. In this paper, we report the sixth incidence overall, which is also the first case of a CM associated with penetrating head injury. Read More

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September 2021

Investigation of tissue level tolerance for cerebral contusion in a controlled cortical impact porcine model.

Traffic Inj Prev 2021 3;22(8):616-622. Epub 2021 Sep 3.

Experimental Neurosurgery and Neuroanatomy, KULeuven, Leuven, Belgium.

Objective: Cerebral contusions (CC) represent a frequent lesion in traumatic brain injury, with potential morbidity from mass effect and tissue loss. Better understanding of the mechanical etiology will help to improve head protection. The goal of this study is to investigate the threshold for mechanical impact parameters to induce CC in an in vivo porcine controlled cortical impact model. Read More

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January 2022

Combined Radiomics Model for Prediction of Hematoma Progression and Clinical Outcome of Cerebral Contusions in Traumatic Brain Injury.

Neurocrit Care 2022 04 4;36(2):441-451. Epub 2021 Aug 4.

Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

Background: Traumatic brain injury is a common and devastating injury that is the leading cause of neurological disability and death worldwide. Patients with cerebral lobe contusion received conservative treatment because of their mild manifestations, but delayed intracranial hematoma may increase and even become life-threatening. We explored the noninvasive method to predict the prognosis of progression and Glasgow Outcome Scale (GOS) by using a quantitative radiomics approach and statistical analysis. Read More

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Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study.

Neurocrit Care 2021 10 26;35(2):335-346. Epub 2021 Jul 26.

Department of Neurological Surgery, Harborview Medical Center, University of Washington School of Medicine, 325 9th Ave, Box 359924, Seattle, WA, 98104, USA.

Background: Traumatic brainstem injury has yet to be incorporated into widely used imaging classification systems for traumatic brain injury (TBI), and questions remain regarding prognostic implications for this TBI subgroup. To address this, retrospective data on patients from the multicenter prospective Transforming Research and Clinical Knowledge in TBI study were studied.

Methods: Patients with brainstem and cerebrum injury (BSI+) were matched by age, sex, and admission Glasgow Coma Scale (GCS) score to patients with cerebrum injuries only. Read More

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October 2021

The usefulness of postmortem computed tomography angiography for subdural hematoma caused by rupture of the cortical artery: A report of two autopsy cases and a literature review.

Leg Med (Tokyo) 2021 Nov 12;53:101941. Epub 2021 Jul 12.

Division of Legal Medicine, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan; Center of Cause of Death Investigation, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Acute subdural hematoma (SDH) occurs following severe head trauma with brain contusion or rupture of bridging veins. Conversely, SDH caused by rupture of a cortical artery without trauma or with minor trauma is also possible. Although over 180 cases of the latter SDH have been reported, they were predominantly diagnosed only during surgery, and therefore, no adequate histological evaluation has been performed. Read More

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November 2021

Pathological Computed Tomography Features Associated With Adverse Outcomes After Mild Traumatic Brain Injury: A TRACK-TBI Study With External Validation in CENTER-TBI.

JAMA Neurol 2021 09;78(9):1137-1148

University of Washington, Seattle.

Importance: A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker for acute traumatic brain injury (TBI). In moderate to severe TBI (Glasgow Coma Scale [GCS] scores 3-12), some CT features have been shown to be associated with outcomes. In mild TBI (mTBI; GCS scores 13-15), distribution and co-occurrence of pathological CT features and their prognostic importance are not well understood. Read More

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September 2021