Differences in c-jun and nNOS expression levels in motoneurons following different kinds of axonal injury in adult rats.
Brain Cell Biol 2008 Dec 24;36(5-6):213-27. Epub 2009 Feb 24.
Department of Anatomy, Zhong Shan School of Medicine, Sun Yat-sen University, Guangzhou 510080, PR China.
In the peripheral nervous system (PNS), root avulsion causes motoneuron degeneration, but the majority of motoneurons can survive axotomy. In order to study the mechanism of motoneuron degeneration, we compared the expression patterns of c-jun and neuronal nitric oxide synthase (nNOS), the well-known molecular players in PNS regeneration and degeneration, among adult rats having undergone axotomy (Ax), avulsion (Av), or pre-axotomy plus secondary avulsion (Ax + Av) of the brachial plexus. Our results showed that the highest and longest-lasting c-jun activation occurred in Ax, which was much stronger than those in Av and Ax + Av. Read More