11,142 results match your criteria Brain Abscess


Central nervous system melioidosis: A systematic review of individual participant data of case reports and case series.

PLoS Negl Trop Dis 2019 Apr 25;13(4):e0007320. Epub 2019 Apr 25.

Department of Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand.

Background: Central nervous system (CNS) melioidosis is rare. However, delayed diagnosis and treatment could lead to fatality. To identify knowledge of CNS melioidosis, we systematically review case reports and case series. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007320
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http://dx.doi.org/10.1371/journal.pntd.0007320DOI Listing
April 2019
1 Read

Brain abscess and pyocephalus: our experience with treatment.

Neurol Neurochir Pol 2019 Apr 25. Epub 2019 Apr 25.

University hospital Ostrava, Czech Republic.

Background: Pyocephalus always presents serious complications in the treatment of brain abscesses, and is associated with high rates of mortality and morbidity. This study aimed to comprehensively evaluate this understandably feared complication from a purely medical perspective by using an evidence-based approach and drawing comparisons from the available literature, which mostly comprises case reports.

Methods: This was a prospective monocentric study of all patients treated for brain abscesses at the Neurosurgery Clinic of the University Hospital Ostrava between 2012 and 2017. Read More

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http://dx.doi.org/10.5603/PJNNS.a2019.0017DOI Listing

Intracranial Complications of Chronic Otitis Media: Why Does It Still Occur?

Ear Nose Throat J 2019 Apr 24:145561319840166. Epub 2019 Apr 24.

1 Department of Otorhinolaryngology, Head and Neck Surgery, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

Intracranial complications secondary to chronic otitis media (COM) include otogenic brain abscess and sinus thrombosis. Intravenous antibiotics and imaging have significantly reduced the incidence of intracranial complications secondary to COM. However, the same does not apply to a developing country like Malaysia, which still experiences persisting otogenic complications. Read More

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http://dx.doi.org/10.1177/0145561319840166DOI Listing

Fungal Malignant Otitis Externa Involves a Cascade of Complications Culminating in Pseudoaneurysm of Internal Maxillary Artery: A Case Report.

Am J Case Rep 2019 Apr 21;20:562-566. Epub 2019 Apr 21.

Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Pseudomonal infection is the most common cause of malignant otitis externa (MOE), which typically affects elderly diabetic patients. Fungi are a rare cause of MOE. MOE can be life-threatening if not recognized and treated promptly. Read More

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https://www.amjcaserep.com/abstract/index/idArt/913469
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http://dx.doi.org/10.12659/AJCR.913469DOI Listing
April 2019
1 Read

Update on fungal infections of the central nervous system: emerging pathogens and emerging diagnostics.

Curr Opin Infect Dis 2019 Jun;32(3):277-284

Department of Medicine.

Purpose Of Review: Fungal infections of the central nervous system (CNS) are relatively uncommon but associated with significant morbidity and mortality. We reviewed recent literature highlighting new approaches to management of these complex patients.

Recent Findings: Fungal infections are increasingly recognized as important causes of CNS disease in both immunocompromised and immunocompetent hosts. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000541DOI Listing
June 2019
3 Reads

Pericranial Flap Anterior Skull Base Reconstruction With Gelfoam Intradural Compression.

J Craniofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Department of Neurosurgery, Chonnam National University Hospital and Medical School, Gwangju, Republic of Korea.

Anterior cranial base reconstruction is occasionally necessary following severe trauma. Several methods for reconstruction have been described and some authors have described their experiences regarding the use of a pericranial flap for anterior skull base reconstruction after trauma. A 26-year-old woman was admitted to our department with multiple facial bone fractures identified using facial bone computed tomography. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005364DOI Listing
March 2019
2 Reads

[Multifocal tuberculosis associated with cerebral toxoplasmosis in an African immigrant immunocompromised patient due to HIV-infection at the Hospital Centre in Soissons, France].

Pan Afr Med J 2018 20;31:47. Epub 2018 Sep 20.

Service de Dermatologie de l'Hôpital National Donka, Université Gamal Abdel Nasser de Conakry, Conakry, République de Guinée.

In the industrialized countries and, in particular, in France, given the means of prevention, early screening and treatment of HIV infection, there is almost no evidence of opportunistic infections among immigrants and in some disadvantaged socio-professional groups. We here report the case of a 42-year old African immigrant HIV1 positive man with impaired general condition hospitalized for infectious syndrome. He had received antiretroviral therapy for 2 years and stopped it four months before admission. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.47.15916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430834PMC
April 2019
2 Reads

Diffusion-weighted magnetic resonance imaging for detection of postoperative intracranial pyogenic abscesses in neurosurgery.

Acta Neurochir (Wien) 2019 Mar 26. Epub 2019 Mar 26.

Department of Neurosurgery, University Hospital, LMU Munich, Marchioninistrasse 15, 81377, Munich, Germany.

Background: Diffusion-weighted magnetic resonance imaging (MRI-DWI) is the modality of choice for detecting intracranial abscesses; however, it is unclear whether prior brain surgery has an influence on its diagnostic value. Thus, we assessed the robustness of MRI-DWI and determination of an ADC cutoff value for detecting intracranial abscesses in patients who underwent brain surgery.

Methods: We retrospectively evaluated 19 patients prior to surgery for postoperative supratentorial parenchymal abscesses by means of MRI-DWI. Read More

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http://dx.doi.org/10.1007/s00701-019-03875-8DOI Listing

Distinctive FDG-PET/CT Findings in Acute Neurological Hospital Care.

Neurohospitalist 2019 Apr 15;9(2):93-99. Epub 2018 Oct 15.

Department of Nuclear Medicine, Municipal Hospital Landshut, Germany.

A compilation of 6 distinctive F-fluorodeoxyglucose positron emission tomography (PET) combined with computed tomography (CT) findings in the acute setting of neurohospital care is presented. In case 1, PET/CT allowed the final diagnosis of circumscribed ischemic infarction by demonstrating a clear pattern of luxury perfusion. In case 2, diagnosis of thalamic abscess was made, whereby PET/CT demonstrated an empty zone. Read More

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http://journals.sagepub.com/doi/10.1177/1941874418805339
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http://dx.doi.org/10.1177/1941874418805339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429674PMC
April 2019
3 Reads

Multiple abscesses in the lower extremities caused by Trichophyton rubrum.

BMC Infect Dis 2019 Mar 20;19(1):271. Epub 2019 Mar 20.

Department of Dermatology, Hangzhou Third Hospital, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310009, People's Republic of China.

Background: Dermatophytes are keratinophilic fungi, that usually infect the hair, stratum corneum, and nails. However, dermatophytes occasionally invade the dermis, subcutaneous tissues, and internal organs, resulting in a condition called deep dermatophytosis. We report a case of an unusual presentation of Trichophyton rubrum infection causing multiple fungal abscesses in the lower extremities of an immunocompromised patient. Read More

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http://dx.doi.org/10.1186/s12879-019-3897-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425592PMC
March 2019
2 Reads

Epicrania Fugax as the presenting symptom of a cerebellar abscess.

Cephalalgia 2019 Mar 20:333102419839793. Epub 2019 Mar 20.

1 Headache Unit, University Hospital of Valladolid, Valladolid, Spain.

Background: Epicrania fugax is included in the appendix of the International Classification of Headache Disorders and is characterized as recurrent brief attacks of linear or zigzag pain moving across the cranial surface, commencing and terminating in the distribution of different nerves. We present a new case of epicrania fugax in which the headache was the presenting symptom of a cerebellar abscess.

Case Report: We present a 58-year-old woman with prior history of Chiari I malformation who underwent suboccipital craniectomy. Read More

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http://dx.doi.org/10.1177/0333102419839793DOI Listing
March 2019
4 Reads

Stenotrophomonas maltophilia brain abscesses after implantation of motor cortex stimulator.

J Neurol Sci 2019 May 14;400:32-33. Epub 2019 Mar 14.

Department of Neurology, University Hospital, Ludwig-Maximilians-University, Munich, Germany.

We describe the first case of a patient with brain abscesses caused by Stenotrophomonas maltophilia as a complication after motor cortex stimulator implantation. Brain abscesses pose a challenge in diagnosis and treatment, because microbiological diagnosis is not always achieved, antibiotic drugs may not penetrate well into the CNS and some bacteria have resistances to typical empirical antibiotic drugs. In this case diagnosis was only made after removal of the stimulator and a long term treatment with antibiotic drugs was necessary. Read More

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http://dx.doi.org/10.1016/j.jns.2019.03.010DOI Listing
May 2019
1 Read

Isolated abdominal nocardiosis in a pediatric renal transplant recipient.

Pediatr Transplant 2019 Mar 19:e13392. Epub 2019 Mar 19.

Division of Pediatric Nephrology, Department of Pediatrics, University Florida, Gainesville, Florida.

Nocardia infection after RT is uncommon. The most common modes of exposure are inhalation of dust containing nocardia or contaminated soil/water and surgical instruments. Isolated abdominal nocardiosis following RT has not been reported. Read More

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http://dx.doi.org/10.1111/petr.13392DOI Listing
March 2019
1 Read

Immunocompetent patient with a brain abscess caused by Nocardia beijingensis in Latin America: A case report.

Medicine (Baltimore) 2019 Mar;98(11):e14879

Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC).

Rationale: Nocardia species are not commonly referred as primary infectious entities but rather as opportunistic pathogens. Infectious cases of Nocardia spp. in immunocompetent individuals are rare. Read More

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http://dx.doi.org/10.1097/MD.0000000000014879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426588PMC
March 2019
4 Reads

Brain abscess caused by Streptococcus intermedius: a case report.

Ann Biol Clin (Paris) 2019 Apr;77(2):184-186

Laboratoire de bactériologie-virologie, Hôpital militaire Avicenne, Marrakech, Maroc.

Streptococcus intermedius is considered as a commensal of the oropharynx, but can be a source of serious infections. We report a case of cerebral abscess in a young man of 18 years, who was admitted to the emergency room for consciousness disorder, and whose cerebral CT showed a frontal mass evoking the diagnosis of abscess. Diagnosis was confirmed by bacteriological examination of puncture fluid which was in favor of Streptococcus intermedius abscess. Read More

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http://dx.doi.org/10.1684/abc.2019.1421DOI Listing
April 2019
1 Read

Complex Microbiome in Brain Abscess Revealed by Whole-Genome Culture-Independent and Culture-Based Sequencing.

J Clin Med 2019 Mar 12;8(3). Epub 2019 Mar 12.

Program in Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan.

Brain abscess is a severe infectious disease with high mortality and mobility. Although culture-based techniques have been widely used for the investigation of microbial composition of brain abscess, these approaches are inherent biased. Recent studies using 16S ribosomal sequencing approaches revealed high complexity of the bacterial community involved in brain abscess but fail to detect fungal and viral composition. Read More

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http://dx.doi.org/10.3390/jcm8030351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462986PMC
March 2019
3 Reads

Risk Factors Associated With Mortality in Patients With Otogenic Brain Abscess.

Otol Neurotol 2019 Apr;40(4):471-477

Division of Otolaryngology-Head and Neck Surgery.

Objective: Otogenic brain abscess is a well-recognized clinical condition that describes brain abscess secondary to an ear infection or mastoiditis. Current evidence remains limited on risk factors associated with mortality as most data are from case series. We aimed to 1) report the mortality rate among patients who did and did not receive mastoidectomy 2) identify factors associated with inpatient mortality. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002138DOI Listing
April 2019
2 Reads

Cotton bud in external ear canal causing necrotising otitis externa and subdural abscess.

BMJ Case Rep 2019 Mar 6;12(3). Epub 2019 Mar 6.

Department of Otolaryngology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK.

Necrotising otitis externa (NOE) is an infection originating in the soft tissues of the external auditory canal (EAC) spreading to the surrounding bone and rarely causing intracranial complications. It is usually caused by and has historically occurred in elderly patients with diabetes or immunodeficiency. EAC foreign body is a risk factor for otitis externa but has not been described in NOE. Read More

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http://dx.doi.org/10.1136/bcr-2018-227971DOI Listing
March 2019
3 Reads

A Patient With Periorbital Necrotizing Fasciitis by Klebsiella pneumoniae.

J Craniofac Surg 2019 Feb 9. Epub 2019 Feb 9.

Department of Ophthalmology.

Periorbital necrotizing fasciitis (NF) is a very rare disease with a mortality rate of 10% to 20%, requiring rapid diagnosis and active treatment. The most common causative organism is Group A β-hemolytic Streptococcus, and trauma, operative incisions, pre-existing ulcers, or injection sites may be predisposing factors for periorbital NF. In this study, the subject, who had a medical history of diabetes mellitus and chronic liver disease, developed periorbital NF suddenly and without any specific triggering factors, and Klebsiella pneumoniae was identified in a necrotic tissue biopsy. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005199DOI Listing
February 2019
5 Reads

Predictors of reoperation and noninfectious complications following craniotomy for cerebral abscess.

Clin Neurol Neurosurg 2019 Apr 27;179:55-59. Epub 2019 Feb 27.

Department of Neurological Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, United States.

Objectives: There is a paucity of literature that examines predictors of reoperation and noninfectious complications following treatment of cerebral abscess with craniotomy. The goal of the present study is to identify predictors for each of these outcomes.

Patients And Methods: The American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database 2012-2016 file was the data source. Read More

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http://dx.doi.org/10.1016/j.clineuro.2019.02.020DOI Listing
April 2019
1 Read

[Utility of multiplex PCR (FilmArray Blood Culture Identification) in other biological liquids. Detection of Streptococcus pyogenes in brain abscess and synovial fluid].

Rev Esp Quimioter 2019 Apr 6;32(2):194-197. Epub 2019 Mar 6.

Dolores Escudero Augusto, Servicio de Medicina Intensiva. Hospital Universitario Central de Asturias. Avenida de Roma s/n 33011 Oviedo. Spain.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441981PMC
April 2019
1 Read

Neurological disorders in a consultant hospital in Northern Tanzania. A cohort study.

eNeurologicalSci 2019 Mar 27;14:101-105. Epub 2018 Nov 27.

Kilimanjaro Christian Medical Centre, PO Box 3010, Moshi, Tanzania.

Objectives: To determine the sociodemographic characteristics, clinical findings and outcome by HIV status in a series of adult patients presenting with neurological disorders (NDs) and admitted to a consultant hospital in Northern Tanzania.

Methods: A cohort study took place over a 6-month period from Oct 2007 to March 2008 and included all adult patients with a neurological disorder admitted to the medical wards.

Results: A total of 1790 patients were admitted during this period, of whom 337 (18. Read More

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http://dx.doi.org/10.1016/j.ensci.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382946PMC
March 2019
3 Reads

Cladophialophora bantiana infection mimicking neuromyelitis optica.

J Neurol Sci 2019 Apr 10;399:169-171. Epub 2018 Dec 10.

Second Department of Internal Medicine, University of Fukui, 23-3 Matsuokashimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan.

Cladophialophora bantiana (C. bantiana) is a life-threatening melanized mycelial fungus causing brain abscess. C. Read More

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http://dx.doi.org/10.1016/j.jns.2018.12.013DOI Listing
April 2019
1 Read

Nocardia infections in solid organ transplantation: Guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation.

Clin Transplant 2019 Feb 28:e13509. Epub 2019 Feb 28.

Division of Infectious Diseases, Department of Medicine, Loyola University Stritch School of Medicine, Maywood, Illinois.

These updated guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation review the diagnosis, prevention, and management of Nocardia infections after solid organ transplantation (SOT). Nocardia infections have increased in the last two decades, likely due to improved detection and identification methods and an expanding immunocompromised population. The risk of developing nocardiosis after transplantation varies with the type of organ transplanted and the immunosuppression regimen used. Read More

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http://dx.doi.org/10.1111/ctr.13509DOI Listing
February 2019
4 Reads

[Cerebral imaging in a delirious patient].

Ned Tijdschr Geneeskd 2019 Feb 26;163. Epub 2019 Feb 26.

Franciscus Gasthuis, afd. Neurologie, Rotterdam.

An 80-year-old woman attended the emergency department with sub-acute confusion and fever. On examination no focal signs were found. Cerebral CT showed an area of hypodensity suspected to be an infarction, but an MRI scan carried out 10 days later showed cerebral abscesses caused by a dental infection that had occurred four weeks previously. Read More

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February 2019
1 Read

Etiology and Clinical Features of Full-Term Neonatal Bacterial Meningitis: A Multicenter Retrospective Cohort Study.

Front Pediatr 2019 13;7:31. Epub 2019 Feb 13.

Department of Pediatric Infectious Diseases, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Neonatal bacterial meningitis is a severe infectious disease with a high risk of neurodevelopmental sequelae. The causative pathogens may be related to specific clinical features of the disease. Therefore, this study aimed at determining the pathogen-specific and clinical features of bacterial meningitis in full-term neonates. Read More

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http://dx.doi.org/10.3389/fped.2019.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381005PMC
February 2019
6 Reads

[A case report of epidural abscess caused by acute frontal sinusitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Feb;33(2):181-182

Epidural epidural abscess is usually secondary to acute frontal sinusitis and osteomyelitis of the frontal bone. Nose-derived intracranial connplications are less common than otogenic ones, and infections caused by nasal and sinus trauma, foreign bodies and surgery are more common than those caused by inflammation alone. The frontal lobe abscess caused by frontal sinusitis is more common in brain abscess with nasal intracranial complications. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.02.022DOI Listing
February 2019
2 Reads

Magnetic resonance imaging spectrum of intracranial tubercular lesions: one disease, many faces.

Pol J Radiol 2018 29;83:e524-e535. Epub 2018 Dec 29.

Jackson Memorial Hospital, Miami, USA.

Tuberculosis is a devastating disease and has shown resurgence in recent years with the advent of acquired immunodeficiency syndrome. Central nervous system involvement is the most devastating form of the disease, comprising 10% of all tuberculosis cases. The causative organism, , incites a granulomatous inflammatory response in the brain, the effects of which can be appreciated on magnetic resonance imaging (MRI), which can thus be used for diagnosis of the same. Read More

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http://dx.doi.org/10.5114/pjr.2018.81408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384409PMC
December 2018

Ischio-anal abscess as a first presentation of complicated diverticular disease.

ANZ J Surg 2019 Feb 21. Epub 2019 Feb 21.

Department of Colorectal Surgery, Liverpool Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/ans.15042DOI Listing
February 2019
2 Reads

Asymptomatic Brain Abscess with Intracerebral Hemorrhage.

Neurocrit Care 2019 Feb 20. Epub 2019 Feb 20.

Department of Neurology, Research Institute of Clinical Medicine, School of Medicine, Chonbuk National University, Jeonju, South Korea.

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http://dx.doi.org/10.1007/s12028-019-00690-yDOI Listing
February 2019
1 Read
2.440 Impact Factor

Genome Mining and Comparative Analysis of Causing Brain Abscess in a Child.

Pathogens 2019 Feb 13;8(1). Epub 2019 Feb 13.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos 36, Lebanon.

(SI) is associated with prolonged hospitalization and low survival rates. The genetic mechanisms involved in brain abscess development and genome evolution in comparison to other members of the group are understudied. We performed a whole-genome comparative analysis of an SI isolate, LAU_SINT, associated with brain abscess following sinusitis with all SI genomes in addition to and . Read More

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http://dx.doi.org/10.3390/pathogens8010022DOI Listing
February 2019
1 Read

Brain Abscess with Intracranial Bone Fragments Migration.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, 230022, Hefei, Anhui, China. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2019.01.221DOI Listing
February 2019
2.417 Impact Factor

Leukotoxic activity of Fusobacterium necrophorum of cattle origin.

Anaerobe 2019 Apr 13;56:51-56. Epub 2019 Feb 13.

Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA. Electronic address:

Fusobacterium necrophorum is a Gram negative, rod-shaped and aero tolerant anaerobe. In animals, it is an opportunistic pathogen frequently associated with necrotic infections, generally called necrobacillosis, such as calf diphtheria, foot rot and liver abscesses in cattle. Two subspecies exist: subsp. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.009DOI Listing
April 2019
1 Read

Melioidosis with a subdural collection - a case report.

BMC Infect Dis 2019 Feb 12;19(1):143. Epub 2019 Feb 12.

Department of Medicine, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.

Background: Melioidosis is an infection caused by Burkholderia pseudomallei, which is more prevalent in the tropics and leads to significant morbidity and mortality. It characteristically produces widespread caseous lesions and abscesses, and can present with varied clinical manifestations. Melioidosis involving the central nervous system is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3782-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373098PMC
February 2019
1 Read

Acupuncture-Induced Cranial Epidural Abscess: Case Report and Review of the Literature.

World Neurosurg 2019 Feb 8. Epub 2019 Feb 8.

Sunnybrook Health Sciences Centre, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

Background: Acupuncture is a common form of alternative medicine that is used for pain control among other modalities of treatment. It is a relatively safe procedure, but complications, including those of infectious etiology, may still occur.

Case Description: A 47-year-old immunosuppressed woman presented with fever, altered level of consciousness, dysphasia, and a left occipital subgaleal fluctuant mass after acupuncture for headaches in the same area. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.189DOI Listing
February 2019
17 Reads

5-ALA Fluorescence In A Case Of Brain Abscess By Aggregatibacter Mimicking A Glioblastoma.

World Neurosurg 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, USA.

Background: At present, differential diagnosis of MRI enhancing lesions can still be challenging. Preoperative imaging is a valuable tool characterized by high informative value, even if false-positive and false-negative results are possible. In this context, 5-aminolevulenic acid (5-ALA) represents a significant adjunct in glioblastoma (GBM) surgery displaying an assumed specific accumulation only in tumor cells. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.190DOI Listing
February 2019
3 Reads

Cladophialophora bantiana brain abscess in lung transplant recipient.

Transpl Infect Dis 2019 04 15;21(2):e13057. Epub 2019 Feb 15.

Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria.

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http://dx.doi.org/10.1111/tid.13057DOI Listing
April 2019
3 Reads

Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.

Neurol Res 2019 May 1;41(5):399-412. Epub 2019 Feb 1.

a Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Frederiksberg , Denmark.

Objective: Ischaemic brain lesions and brain abscesses are frequent in both human and animal cases of septic embolic stroke. However, existing models of brain infection do not reflect central aspects of septic embolic stroke. Our aim was to compare septic and non-septic embolic stroke in order to identify gene expressions, inflammatory mediators and brain damage in a rat model. Read More

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http://dx.doi.org/10.1080/01616412.2019.1573455DOI Listing
May 2019
1 Read
1.449 Impact Factor

Disseminated Nocardia asiatica infection in an immunocompromised individual: A rare entity needs careful vigilance.

J Infect Public Health 2019 Mar - Apr;12(2):167-170. Epub 2019 Jan 28.

Department of Microbiology, Manipal Academy of Higher Education, Manipal, India.

Nocardia asteroides complex and Nocardia brasiliensis are common etiological agents of disseminated nocardiosis among immunocompromised individuals. Here we reported an uncommon case of disseminated nocardiosis with the involvement of lung, brain, soft tissue & pancreas by a rarely isolated species Nocardia asiatica in a HIV infected individual. Diagnosis was initially misinterpreted as tuberculosis based on the clinical and radiological findings. Read More

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http://dx.doi.org/10.1016/j.jiph.2018.12.008DOI Listing
April 2019
7 Reads

Abscess Formation in Metastatic Brain Tumor with History of Immune Checkpoint Inhibitor: A Case Report.

NMC Case Rep J 2019 Jan 18;6(1):11-15. Epub 2018 Dec 18.

Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan.

We present the case of a 68-year-old man with brain metastasis from lung cancer and a history of immune checkpoint inhibitor administration, with overlapping abscess within the metastatic lesion. He initially received antibiotic treatment under a diagnosis of brain abscess because of a hyper-intense area on diffusion-weighted imaging inside the gadolinium-enhanced wall. The size of the enhanced lesion did not change much, but the extent of perifocal edema decreased after antibiotic treatment. Read More

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http://dx.doi.org/10.2176/nmccrj.cr.2018-0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350031PMC
January 2019
4 Reads

Gemella morbillorum Cryptogenic Brain Abscess: A Case Report and Literature Review.

Cureus 2018 Nov 19;10(11):e3612. Epub 2018 Nov 19.

Internal Medicine, Detroit Medical Center - Wayne State University, Detroit, USA.

A case of cryptogenic brain abscess caused by  is reported in a 28-year-old immunocompetent man who presented with seizures and hemiparesis. The patient underwent successful stereotactic drainage of the abscess with complete resolution of symptoms and radiographic evidence of resolution. We report the significant pathogenic potential of a normal commensal rarely identified in neurologic infections. Read More

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http://dx.doi.org/10.7759/cureus.3612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345354PMC
November 2018
4 Reads

A Clinical Report of Two Cases of Cryptogenic Brain Abscess and a Relevant Literature Review.

Front Neurosci 2018 14;12:1054. Epub 2019 Jan 14.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China.

Brain abscess, a severe intracranial infectious disease, refers to the parenchyma abscess caused by local infection or remote spread. Recently, advancements in modern medicine, especially the wide application of antimicrobial drugs, have contributed to the gradual decrease in the prevalence of this disease. However, cases of cryptogenic brain abscess that feature an unknown origin and atypical symptoms are rising. Read More

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http://dx.doi.org/10.3389/fnins.2018.01054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339901PMC
January 2019
4 Reads

Outcome of Primary Bone Fragment Replacement in Pediatric Patients with Depressed Skull Fracture.

Pediatr Neurosurg 2019 23;54(1):28-35. Epub 2019 Jan 23.

Department of Neurosurgery, Gaziantep Medical Park Hospital, Gaziantep, Turkey.

Objective: To evaluate pediatric patients who were operated with the diagnosis of depressed skull fracture.

Methods: The records of pediatric patients who presented with traumatic head injury to multicenter neurosurgery clinics between 2002 and 2018 and who were operated with a diagnosis of depressed skull fracture were retrospectively reviewed. All of the patients underwent primary bone fragment replacement operation, and the patients' own bone flaps were used to repair depressed skull fractures in all of them. Read More

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https://www.karger.com/Article/FullText/495807
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http://dx.doi.org/10.1159/000495807DOI Listing
January 2019
5 Reads

HADC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-Induced Mouse Model of Neuroinflammation and Microglial Activation.

Int J Mol Sci 2019 Jan 18;20(2). Epub 2019 Jan 18.

Graduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110-31, Taiwan.

Glial activation and neuroinflammatory processes play important roles in the pathogenesis of brain abscess and neurodegenerative diseases. Activated glial cells can secrete various proinflammatory cytokines and neurotoxic mediators, which contribute to the exacerbation of neuronal cell death. The inhibition of glial activation has been shown to alleviate neurodegenerative conditions. Read More

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http://dx.doi.org/10.3390/ijms20020410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359084PMC
January 2019

Demyelinating lesions behaving like aggressive tumours on advanced MRI techniques.

Neuroradiol J 2019 Apr 22;32(2):103-107. Epub 2019 Jan 22.

4 Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, USA.

Tumefactive demyelinating lesions are a rare disorder in which inflammatory demyelination manifests as solitary or multiple focal brain lesions (greater than 2 cm in size), which can be mistaken for glioma, lymphoma, metastasis and in some cases even brain abscess. The symptomatology of tumefactive demyelinating lesions depends on the white matter area involved and includes quickly progressing neurological deterioration of motor, sensory and visual function, praxis, language and mood impairment, as well as seizures. Recognising the key imaging features in a patient with a prior history of demyelination may expedite appropriate management. Read More

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http://dx.doi.org/10.1177/1971400919826394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410458PMC
April 2019
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Evaluation of next-generation sequencing for the pathogenic diagnosis of children brain abscesses.

J Infect 2019 Apr 16;78(4):323-337. Epub 2019 Jan 16.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nan Lishi Road, Beijing 100045, China. Electronic address:

In this study, we applied metagenomic next-generation sequencing (mNGS) to detect the causative pathogens in brain abscess samples from 4 pediatric patients. NGS could offer unbiased sequencing and rapid diagnosis of causative pathogens, moreover, it could detect multiple pathogenic microorganisms from abscess samples. In our study, Fusobacterium nucleatum, and Streptococcus intermedius or combinations of them were found in 3/4 of polymicrobial brain abscesses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193000
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http://dx.doi.org/10.1016/j.jinf.2019.01.003DOI Listing
April 2019
9 Reads

The Tunnel Sign Revisited: A Novel Observation of Cerebral Melioidosis Mimicking Sparganosis.

J Radiol Case Rep 2018 Aug 31;12(8):1-11. Epub 2018 Aug 31.

Department of Diagnostic Imaging, National University Hospital, Singapore.

The tunnel sign has been described as a specific feature of cerebral sparganosis. We present a case of a 55-year-old gentleman found to have cerebral melioidosis and with initial imaging mimicking the appearance of sparganosis. This suggests that the tunnel sign in brain abscesses may be specific for infection by Burkholderia Pseudomallei, Spirometra Mansoni or Listeria Monocytogenes. Read More

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http://www.radiologycases.com/index.php/radiologycases/artic
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http://dx.doi.org/10.3941/jrcr.v12i8.3441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312124PMC
August 2018
10 Reads

Molecular and clinical evidence of Aeromonas hydrophila and Fusarium solani co-infection in narrow-clawed crayfish Astacus leptodactylus.

Dis Aquat Organ 2019 Jan;132(2):135-141

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Co-infections occur when a host is infected by 2 or more different pathogen types, either by secondary or simultaneous infections, and are very frequent in nature. In this study, 10 narrow-clawed crayfish Astacus leptodactylus with signs of disease were collected from Haft Baram Lake (Fars province, southern Iran). Samples of fluid from inside the intact abscess and melanized lesions in the cuticle were cultured aseptically onto brain heart infusion agar and Sabouraud dextrose agar for bacterial and fungal agents, respectively. Read More

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http://dx.doi.org/10.3354/dao03309DOI Listing
January 2019

Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy.

Case Rep Ophthalmol Med 2018 2;2018:8306163. Epub 2018 Dec 2.

Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, USA.

Diagnosing culture-proven endophthalmitis is complicated by the insufficient yield of intraocular samples and the variety of etiologies which mimic true endophthalmitis. In cases of impending vision loss where vitreous biopsy cannot provide a definitive diagnosis, transvitreal retinochoroidal biopsy can be an effective next step. Our case is a 48-year-old male with B-cell acute lymphoblastic leukemia that presented with counting fingers vision, redness, and tearing of the left eye. Read More

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http://dx.doi.org/10.1155/2018/8306163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304639PMC
December 2018
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Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
February 2019
5 Reads