11,092 results match your criteria Brain Abscess


Brain Abscess with Intracranial Bone Fragments Migration.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurosurgery, the First Affiliated Hospital of Anhui Medical University, 230022, Hefei, Anhui, China. Electronic address:

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http://dx.doi.org/10.1016/j.wneu.2019.01.221DOI Listing
February 2019

Leukotoxic activity of Fusobacterium necrophorum of cattle origin.

Anaerobe 2019 Feb 13. Epub 2019 Feb 13.

Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA. Electronic address:

Fusobacterium necrophorum is a Gram negative, rod-shaped and aero tolerant anaerobe. In animals, it is an opportunistic pathogen frequently associated with necrotic infections, generally called necrobacillosis, such as calf diphtheria, foot rot and liver abscesses in cattle. Two subspecies exist: subsp. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.009DOI Listing
February 2019

Melioidosis with a subdural collection - a case report.

BMC Infect Dis 2019 Feb 12;19(1):143. Epub 2019 Feb 12.

Department of Medicine, Faculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.

Background: Melioidosis is an infection caused by Burkholderia pseudomallei, which is more prevalent in the tropics and leads to significant morbidity and mortality. It characteristically produces widespread caseous lesions and abscesses, and can present with varied clinical manifestations. Melioidosis involving the central nervous system is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3782-0DOI Listing
February 2019

5-ALA Fluorescence In A Case Of Brain Abscess By Aggregatibacter Mimicking A Glioblastoma.

World Neurosurg 2019 Feb 8. Epub 2019 Feb 8.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, USA.

Background: At present, differential diagnosis of MRI enhancing lesions can still be challenging. Preoperative imaging is a valuable tool characterized by high informative value, even if false-positive and false-negative results are possible. In this context, 5-aminolevulenic acid (5-ALA) represents a significant adjunct in glioblastoma (GBM) surgery displaying an assumed specific accumulation only in tumor cells. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.190DOI Listing
February 2019
1 Read

Cladophialophora bantiana brain abscess in lung transplant recipient.

Transpl Infect Dis 2019 Feb 3:e13057. Epub 2019 Feb 3.

Joseph Ayobabalola University, Ikeji-Arakeji, Nigeria.

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http://dx.doi.org/10.1111/tid.13057DOI Listing
February 2019
1 Read

Staphylococcus aureus infected embolic stroke upregulates Orm1 and Cxcl2 in a rat model of septic stroke pathology.

Neurol Res 2019 Feb 1:1-14. Epub 2019 Feb 1.

a Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences , University of Copenhagen , Frederiksberg , Denmark.

Objective: Ischaemic brain lesions and brain abscesses are frequent in both human and animal cases of septic embolic stroke. However, existing models of brain infection do not reflect central aspects of septic embolic stroke. Our aim was to compare septic and non-septic embolic stroke in order to identify gene expressions, inflammatory mediators and brain damage in a rat model. Read More

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http://dx.doi.org/10.1080/01616412.2019.1573455DOI Listing
February 2019

Disseminated Nocardia asiatica infection in an immunocompromised individual: A rare entity needs careful vigilance.

J Infect Public Health 2019 Jan 28. Epub 2019 Jan 28.

Department of Microbiology, Manipal Academy of Higher Education, Manipal, India.

Nocardia asteroides complex and Nocardia brasiliensis are common etiological agents of disseminated nocardiosis among immunocompromised individuals. Here we reported an uncommon case of disseminated nocardiosis with the involvement of lung, brain, soft tissue & pancreas by a rarely isolated species Nocardia asiatica in a HIV infected individual. Diagnosis was initially misinterpreted as tuberculosis based on the clinical and radiological findings. Read More

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http://dx.doi.org/10.1016/j.jiph.2018.12.008DOI Listing
January 2019
2 Reads

Abscess Formation in Metastatic Brain Tumor with History of Immune Checkpoint Inhibitor: A Case Report.

NMC Case Rep J 2019 Jan 18;6(1):11-15. Epub 2018 Dec 18.

Department of Neurosurgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima, Japan.

We present the case of a 68-year-old man with brain metastasis from lung cancer and a history of immune checkpoint inhibitor administration, with overlapping abscess within the metastatic lesion. He initially received antibiotic treatment under a diagnosis of brain abscess because of a hyper-intense area on diffusion-weighted imaging inside the gadolinium-enhanced wall. The size of the enhanced lesion did not change much, but the extent of perifocal edema decreased after antibiotic treatment. Read More

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http://dx.doi.org/10.2176/nmccrj.cr.2018-0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350031PMC
January 2019
1 Read

Gemella morbillorum Cryptogenic Brain Abscess: A Case Report and Literature Review.

Cureus 2018 Nov 19;10(11):e3612. Epub 2018 Nov 19.

Internal Medicine, Detroit Medical Center - Wayne State University, Detroit, USA.

A case of cryptogenic brain abscess caused by  is reported in a 28-year-old immunocompetent man who presented with seizures and hemiparesis. The patient underwent successful stereotactic drainage of the abscess with complete resolution of symptoms and radiographic evidence of resolution. We report the significant pathogenic potential of a normal commensal rarely identified in neurologic infections. Read More

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http://dx.doi.org/10.7759/cureus.3612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345354PMC
November 2018
2 Reads

A Clinical Report of Two Cases of Cryptogenic Brain Abscess and a Relevant Literature Review.

Front Neurosci 2018 14;12:1054. Epub 2019 Jan 14.

Department of Neurosurgery, Yijishan Hospital, Wannan Medical College, Wuhu, China.

Brain abscess, a severe intracranial infectious disease, refers to the parenchyma abscess caused by local infection or remote spread. Recently, advancements in modern medicine, especially the wide application of antimicrobial drugs, have contributed to the gradual decrease in the prevalence of this disease. However, cases of cryptogenic brain abscess that feature an unknown origin and atypical symptoms are rising. Read More

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http://dx.doi.org/10.3389/fnins.2018.01054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339901PMC
January 2019
2 Reads

Outcome of Primary Bone Fragment Replacement in Pediatric Patients with Depressed Skull Fracture.

Pediatr Neurosurg 2019 Jan 23:1-8. Epub 2019 Jan 23.

Department of Neurosurgery, Gaziantep Medical Park Hospital, Gaziantep, Turkey.

Objective: To evaluate pediatric patients who were operated with the diagnosis of depressed skull fracture.

Methods: The records of pediatric patients who presented with traumatic head injury to multicenter neurosurgery clinics between 2002 and 2018 and who were operated with a diagnosis of depressed skull fracture were retrospectively reviewed. All of the patients underwent primary bone fragment replacement operation, and the patients' own bone flaps were used to repair depressed skull fractures in all of them. Read More

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https://www.karger.com/Article/FullText/495807
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http://dx.doi.org/10.1159/000495807DOI Listing
January 2019
3 Reads

HADC8 Inhibitor WK2-16 Therapeutically Targets Lipopolysaccharide-Induced Mouse Model of Neuroinflammation and Microglial Activation.

Int J Mol Sci 2019 Jan 18;20(2). Epub 2019 Jan 18.

Graduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110-31, Taiwan.

Glial activation and neuroinflammatory processes play important roles in the pathogenesis of brain abscess and neurodegenerative diseases. Activated glial cells can secrete various proinflammatory cytokines and neurotoxic mediators, which contribute to the exacerbation of neuronal cell death. The inhibition of glial activation has been shown to alleviate neurodegenerative conditions. Read More

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http://dx.doi.org/10.3390/ijms20020410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359084PMC
January 2019

Demyelinating lesions behaving like aggressive tumours on advanced MRI techniques.

Neuroradiol J 2019 Jan 22:1971400919826394. Epub 2019 Jan 22.

4 Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, USA.

Tumefactive demyelinating lesions are a rare disorder in which inflammatory demyelination manifests as solitary or multiple focal brain lesions (greater than 2 cm in size), which can be mistaken for glioma, lymphoma, metastasis and in some cases even brain abscess. The symptomatology of tumefactive demyelinating lesions depends on the white matter area involved and includes quickly progressing neurological deterioration of motor, sensory and visual function, praxis, language and mood impairment, as well as seizures. Recognising the key imaging features in a patient with a prior history of demyelination may expedite appropriate management. Read More

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http://dx.doi.org/10.1177/1971400919826394DOI Listing
January 2019
3 Reads

Evaluation of next-generation sequencing for the pathogenic diagnosis of children brain abscesses.

J Infect 2019 Jan 16. Epub 2019 Jan 16.

Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Infectious Diseases, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, No. 56 Nan Lishi Road, Beijing 100045, China. Electronic address:

In this study, we applied metagenomic next-generation sequencing (mNGS) to detect the causative pathogens in brain abscess samples from 4 pediatric patients. NGS could offer unbiased sequencing and rapid diagnosis of causative pathogens, moreover, it could detect multiple pathogenic microorganisms from abscess samples. In our study, Fusobacterium nucleatum, and Streptococcus intermedius or combinations of them were found in 3/4 of polymicrobial brain abscesses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01634453193000
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http://dx.doi.org/10.1016/j.jinf.2019.01.003DOI Listing
January 2019
5 Reads

The Tunnel Sign Revisited: A Novel Observation of Cerebral Melioidosis Mimicking Sparganosis.

J Radiol Case Rep 2018 Aug 31;12(8):1-11. Epub 2018 Aug 31.

Department of Diagnostic Imaging, National University Hospital, Singapore.

The tunnel sign has been described as a specific feature of cerebral sparganosis. We present a case of a 55-year-old gentleman found to have cerebral melioidosis and with initial imaging mimicking the appearance of sparganosis. This suggests that the tunnel sign in brain abscesses may be specific for infection by Burkholderia Pseudomallei, Spirometra Mansoni or Listeria Monocytogenes. Read More

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http://www.radiologycases.com/index.php/radiologycases/artic
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http://dx.doi.org/10.3941/jrcr.v12i8.3441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312124PMC
August 2018
3 Reads

Molecular and clinical evidence of Aeromonas hydrophila and Fusarium solani co-infection in narrow-clawed crayfish Astacus leptodactylus.

Dis Aquat Organ 2019 Jan;132(2):135-141

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.

Co-infections occur when a host is infected by 2 or more different pathogen types, either by secondary or simultaneous infections, and are very frequent in nature. In this study, 10 narrow-clawed crayfish Astacus leptodactylus with signs of disease were collected from Haft Baram Lake (Fars province, southern Iran). Samples of fluid from inside the intact abscess and melanized lesions in the cuticle were cultured aseptically onto brain heart infusion agar and Sabouraud dextrose agar for bacterial and fungal agents, respectively. Read More

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http://dx.doi.org/10.3354/dao03309DOI Listing
January 2019

Diagnosis of Vitreoretinal Aspergillosis with Transvitreal Retinochoroidal Biopsy.

Case Rep Ophthalmol Med 2018 2;2018:8306163. Epub 2018 Dec 2.

Department of Ophthalmology, Drexel University College of Medicine, Philadelphia, PA, USA.

Diagnosing culture-proven endophthalmitis is complicated by the insufficient yield of intraocular samples and the variety of etiologies which mimic true endophthalmitis. In cases of impending vision loss where vitreous biopsy cannot provide a definitive diagnosis, transvitreal retinochoroidal biopsy can be an effective next step. Our case is a 48-year-old male with B-cell acute lymphoblastic leukemia that presented with counting fingers vision, redness, and tearing of the left eye. Read More

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http://dx.doi.org/10.1155/2018/8306163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304639PMC
December 2018
8 Reads

Suprasellar chordoid glioma: a report of two cases.

Arch Endocrinol Metab 2018 ;62(6):648-654

Instituto de Investigaciones Neurológicas "Dr. Raúl Carrea", FLENI, Pathology, Buenos Aires, Argentina.

Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. Read More

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http://dx.doi.org/10.20945/2359-3997000000092DOI Listing
February 2019
2 Reads

Silent Tumefactive Demyelinating Lesions and Radiologically Isolated Syndrome.

Case Rep Neurol Med 2018 28;2018:8409247. Epub 2018 Nov 28.

Ege University, Faculty of Medicine, Department of Radiology, Izmir, Turkey.

Demyelinating lesions larger than 2 cm in diameter, with or without edema, are known as tumefactive demyelinating lesions (TDLs). They constitute a rare inflammatory demyelinating disorder of the central nervous system. TDLs are typically characterized by headaches, cortical symptoms such as aphasia, hemiparesis, hemisensory deficits, seizures, and changes in consciousness. Read More

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https://www.hindawi.com/journals/crinm/2018/8409247/
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http://dx.doi.org/10.1155/2018/8409247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304209PMC
November 2018
3 Reads

[An Unusual Hemisphere Syndrome].

Praxis (Bern 1994) 2019 Jan;108(1):59-62

1 Spital Simmental-Thun-Saanenland AG, Thun.

An Unusual Hemisphere Syndrome Abstract. A patient with known hereditary hemorrhagic telangiectasia presents with transient right arm weakness and dizziness. A transient ischemic attack is diagnosed on clinical and risk factors. Read More

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http://dx.doi.org/10.1024/1661-8157/a003154DOI Listing
January 2019
2 Reads

Multiple cerebral abscesses in a renal transplant recipient: Two swords in one scabbard!

Med Mycol Case Rep 2019 Mar 21;23:50-52. Epub 2018 Dec 21.

Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Although rare, both () and have been known to be associated with brain abscess in renal transplant recipients (RTRs), however co-infection has never been reported till date. In the present case, 40 years old renal transplant recipient on curtailed immunosuppressive therapy presented with progressive headache and altered sensorium. The computed tomography of head showed multiple ring-enhancing discrete lesions in the left frontal lobe, with moderate perilesional oedema. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312856PMC
March 2019
2 Reads

Brain abscess caused by Cladophialophora bantiana: Total remission after full resection and short-course Voriconazole treatment.

Med Mycol Case Rep 2019 Mar 11;23:43-45. Epub 2018 Dec 11.

Division of Infectious Diseases and Hospital Epidemiology, Hospital of St.Gallen, Rorschacherstrasse 95, 9007 St.Gallen, Switzerland.

We report on a brain abscess in an immunocompetent man caused by , a black mold known to prefer the brain for abscess-formations with a mortality rate up to 65%. The published cases so far show different therapeutical approaches and outcomes, whereby a standardized treatment could not yet be established. We report on a case of brain abscess with total remission of the abscess after full resection and a short antifungal treatment. Read More

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http://dx.doi.org/10.1016/j.mmcr.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304373PMC

Calcification in the wall of brain abscess.

BMJ Case Rep 2019 Jan 7;12(1). Epub 2019 Jan 7.

Department of Neurology, Vinayaka Neuro Multispecialty Clinic, Warangal, Telangana, India.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22842
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http://dx.doi.org/10.1136/bcr-2018-228426DOI Listing
January 2019
1 Read

Spontaneous cerebral abscess due to in an immunocompetent male patient: A case report and review of literature.

World J Clin Cases 2018 Dec;6(16):1169-1174

Department of Internal Medicine, Division of Infectious Diseases, University of Patras Medical School, Patras 26504, Greece.

Background: () is considered a non-pathogenic microorganism of the genus and a common laboratory contaminant. Only scarce reports of central nervous system infection have been reported, mainly in the form of pyogenic meningitis, usually in cases of direct inoculation by trauma or iatrogenically.

Case Summary: A 51-year-old man, with a free previous medical history, presented to the Emergency Department of our hospital complaining of recurrent episodes of left upper limb weakness, during the last month, which had been worsened the last 48 h. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i16.1169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306642PMC
December 2018
1 Read

Neuroradiological worsening of brain abscess after adalimumab and methotrexate withdrawal: Do not forget Immune Reconstitution Inflammatory Syndrome.

J Clin Neurosci 2019 Jan 2. Epub 2019 Jan 2.

Hospital Universitario de La Princesa, Department of Neurology, Madrid, Spain.

The incidence of brain abscess is higher among immunosuppressed patients. We report a case of a brain abscess in the temporal lobe in a patient under treatment with adalimumab and methotrexate, who developed radiological worsening. Clinical remission was essential to suspect Immune Reconstitution Inflammatory Syndrome and to continue empirical antimicrobial therapy due to the low suspicion of worsening of the abscess itself. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09675868183203
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http://dx.doi.org/10.1016/j.jocn.2018.12.018DOI Listing
January 2019
5 Reads

Pyogenic brain abscess in children: a Tunisian multi-center experience.

Afr Health Sci 2018 Sep;18(3):560-568

Pediatric Department, Sahloul Hospital, Sousse Tunisia, Sousse 4051 Tunisia.

Background: Brain abscess (BA) is an uncommon intracranial suppurative infectious disease, especially in children. Treatment involves surgery and prolonged courses of antibiotics.

Objectives: Our study aimed to describe clinical characteristics of children with BA treated in middle Tunisian health centers. Read More

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https://www.ajol.info/index.php/ahs/article/view/176125
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http://dx.doi.org/10.4314/ahs.v18i3.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307026PMC
September 2018
2 Reads

Typhimurium para-aortic root abscess managed non-surgically.

IDCases 2019 21;15:e00476. Epub 2018 Dec 21.

Hurley Medical Center, Department of Internal Medicine, Flint, MI, USA.

Introduction: Para-aortic root abscess is a destructive vascular condition that can result in significant morbidity and mortality. We describe a rare case of para-aortic root abscess due to Typhimurium that was successfully managed medically.

Presentation Of Case: A 72-year-old diabetic man with a prosthetic aortic graft presented with fever and expressive aphasia with left sided weakness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509173022
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http://dx.doi.org/10.1016/j.idcr.2018.e00476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307035PMC
December 2018
8 Reads

The impact of Bacillus subtilis 18 isolated from Tibetan yaks on growth performance and gut microbial community in mice.

Microb Pathog 2018 Dec 21;128:153-161. Epub 2018 Dec 21.

College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, PR China; College of Animals Husbandry and Veterinary Medicine, Tibet Agricultural and Animal Husbandry University, Linzhi, Tibet, 860000, PR China. Electronic address:

The purpose of this study was to evaluate the effects of Bacillus subtilis 18 (BS-18) isolated from free-ranging Tibetan yaks in high altitude regions of Tibet (3600 m) on growth performance and gut microbial community in mice. In this study, mice (15-day-old) were used as an animal model and raised under standard conditions. A total of 20 KM mice were divided equally into two groups: control group (feed and drink freely), experimental group (feed and drink freely + 1 × 10 CFU/day BS-18). Read More

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http://dx.doi.org/10.1016/j.micpath.2018.12.031DOI Listing
December 2018
2 Reads

The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study.

Clin Microbiol Infect 2018 Dec 21. Epub 2018 Dec 21.

Department of Microbiology, Haukeland University Hospital, Bergen, Norway.

Objectives: The view of pleural empyema as a complication of bacterial pneumonia is changing because many patients lack evidence of underlying pneumonia. To further our understanding of pathophysiological mechanisms, we conducted in-depth microbiological characterization of empyemas in clinically well-characterized patients and investigated observed microbial parallels between pleural empyemas and brain abscesses.

Methods: Culture-positive and/or 16S rRNA gene PCR-positive pleural fluids were analysed using massive parallel sequencing of the 16S rRNA and rpoB genes. Read More

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http://dx.doi.org/10.1016/j.cmi.2018.11.030DOI Listing
December 2018
4 Reads

Case report of Actinomyces turicensis meningitis as a complication of purulent mastoiditis.

BMC Infect Dis 2018 Dec 20;18(1):686. Epub 2018 Dec 20.

Semmelweis University, Institute of Medical Microbiology, Budapest, Hungary.

Background: Central nervous system (CNS) infections caused by Actinomyces spp. including brain abscess, actinomycoma, subdural empyema and epidural abscess are well described, however reports of Actinomyces-associated meningitis are scarcely reported.

Case Report: We present the case of a 43-year-old Hungarian male patient with poor socioeconomic status who developed acute bacterial meningitis caused by Actinomyces turicensis originating from the left side mastoiditis. Read More

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http://dx.doi.org/10.1186/s12879-018-3610-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302302PMC
December 2018
5 Reads

Extensive perivascular dissemination of cerebral miliary tuberculomas: a case report and review of the literature.

Acta Radiol Open 2018 Dec 11;7(12):2058460118817918. Epub 2018 Dec 11.

Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan.

Cerebral tuberculosis (TB) presents most frequently as meningitis in the basilar cistern; however, it can also manifest in various other ways, such as localized encephalitis, abscess, and tuberculoma. Here, focusing on imaging findings, we report an immunocompetent case who demonstrated multiple parenchymal lesions and was diagnosed with cerebral TB after testing positive on QuantiFERON (QTF); her clinical signs/symptoms and laboratory findings responded well to anti-TB medication therapy. The patient was a 60-year-old woman with the chief complaints of headache and consciousness disturbance. Read More

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http://dx.doi.org/10.1177/2058460118817918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291888PMC
December 2018
1 Read

Multi-systemic melioidosis: a clinical, neurological, and radiological case study from Hainan Province, China.

BMC Infect Dis 2018 Dec 12;18(1):649. Epub 2018 Dec 12.

Department of Radiology, Hainan General Hospital, No. 19 Xiuhua Road, Xiuying District, Haikou, 570311, Hainan, People's Republic of China.

Background: Melioidosis is a tropical disease caused by Burkholderia pseudomallei (B. pseudomallei). It can infect any organ system and lead to multiple abscesses. Read More

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http://dx.doi.org/10.1186/s12879-018-3569-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291948PMC
December 2018

Safety and Efficacy of Rituximab in Multiple Sclerosis: A Retrospective Observational Study.

J Immunol Res 2018 12;2018:9084759. Epub 2018 Nov 12.

Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Beirut, Lebanon.

Objective: To evaluate the efficacy and safety of rituximab in multiple sclerosis in a clinical practice setting.

Methods: Clinical data for all adult patients with multiple sclerosis (MS) treated with off-label rituximab at a single MS center in Lebanon between March 2008 and April 2017 were retrospectively collected from medical charts. The main efficacy outcomes assessed were annualized relapse rate (ARR) and proportion of patients free from relapses, disability progression, or magnetic resonance imaging (MRI) activity. Read More

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https://www.hindawi.com/journals/jir/2018/9084759/
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http://dx.doi.org/10.1155/2018/9084759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260423PMC
January 2019
5 Reads

Blood Culture-Negative but Clinically Diagnosed Infective Endocarditis Complicated by Intracranial Mycotic Aneurysm, Brain Abscess, and Posterior Tibial Artery Pseudoaneurysm.

Case Rep Neurol Med 2018 8;2018:1236502. Epub 2018 Nov 8.

Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD, USA.

Blood culture-negative endocarditis is often severe and difficult to diagnose. It is necessary to emphasize the importance for the early diagnosis and accurate treatment of blood culture-negative endocarditis. Here, we described the relevant clinical information of a blood culture-negative but clinically diagnosed infective endocarditis complicated by intracranial mycotic aneurysm, brain abscess, and posterior tibial artery pseudoaneurysm. Read More

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https://www.hindawi.com/journals/crinm/2018/1236502/
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http://dx.doi.org/10.1155/2018/1236502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250033PMC
November 2018
2 Reads

Brain abscess in relation to infection of the ventriculo-peritoneal derivation system.

Rev Clin Esp 2018 Oct 24. Epub 2018 Oct 24.

Servicio de Medicina Interna, Hospital de Cabueñes, Gijón, Asturias, España.

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http://dx.doi.org/10.1016/j.rce.2018.06.013DOI Listing
October 2018

Secondary pituitary abscess following transsphenoidal surgery with recurrent meningitis: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13458

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Rationale: The transsphenoidal surgical (TS) approach to sellar masses is the preferred surgical route in most cases. Secondary pituitary abscess (PA) following TS is an extremely rare but serious postoperative complication with potentially high disability and mortality.

Patient Concerns: We describe an uncommon case of secondary PA in a 42-year-old woman, who underwent uncomplicated transsphenoidal procedures without cerebrospinal fluid leak, to treat primary Rathke cleft cyst. Read More

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http://dx.doi.org/10.1097/MD.0000000000013458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283055PMC
November 2018
2 Reads

Septicemia, Meningitis and Bilateral Subdural Empyema in an Infant Caused by Staphylococcus aureus.

Mymensingh Med J 2018 Oct;27(4):898-903

Dr Shameem Ahmed, Senior Consultant Neurosurgeon, Department of Neurosurgery, Apollo Hospitals (Unit: International Hospital), Guwahati , India.

Staphylococcus aureus is a global bacterial pathogen. It is an uncommon pathogen causing central nervous system infections, accounting for <1% cases of bacterial meningitis. Sinusitis, trauma and presence of an intracranial device have been reported as risk factors for developing meningitis and brain abscesses. Read More

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October 2018
3 Reads

Disseminated toxoplasmosis with atypical symptoms which developed with exacerbation of systemic lupus erythematosus.

Lupus 2019 Jan 28;28(1):133-136. Epub 2018 Nov 28.

1 Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan.

Toxoplasma is a common parasite worldwide that mainly affects the brain, lungs and eyes. Although toxoplasmic encephalitis is a lethal disease without treatment, past case reports show most patients with systemic lupus erythematosus who developed toxoplasmic encephalitis were misdiagnosed and treated as neuropsychiatric systemic lupus erythematosus, which led to unfavorable outcomes. We herein describe a case of disseminated toxoplasmosis affecting all the above organs with atypical symptoms, which developed with exacerbation of systemic lupus erythematosus. Read More

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http://dx.doi.org/10.1177/0961203318815583DOI Listing
January 2019
2 Reads

Unusual presentation of epilepsy of germinoma located in the frontal-lobe: case report and literature review.

Br J Neurosurg 2018 Nov 19:1-3. Epub 2018 Nov 19.

a Department of Neurosurgery , The First Affiliated Hospital of Zhengzhou University , ZhengZhou , HeNan Province , PR China.

Germinoma is rare in peripheral lobar locations in the brain, with only 10 cases of primary frontal lobe germinoma having been reported in the previous literature. Epilepsy is a rare manifestation of germinomas. We describe an unusual case of a primary frontal germinoma in a 21-year-old man who presented with epilepsy. Read More

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http://dx.doi.org/10.1080/02688697.2018.1523367DOI Listing
November 2018
8 Reads

Current Practices of Intraventricular Antibiotic Therapy in the Treatment of Meningitis and Ventriculitis: Results from a Multicenter Retrospective Cohort Study.

Neurocrit Care 2018 Nov 16. Epub 2018 Nov 16.

Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.

Background: Central nervous system (CNS) infections are particularly prevalent in the adult neurocritical care patient population and are associated with significant morbidity and mortality. Factors relevant to the nature of CNS infections pose significant challenges to clinicians treating afflicted patients. Intraventricular (IVT) administration of antibiotics may offer several benefits over systemic therapy; however, the outcomes and current practices of such treatments are poorly described in the literature. Read More

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http://link.springer.com/10.1007/s12028-018-0647-0
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http://dx.doi.org/10.1007/s12028-018-0647-0DOI Listing
November 2018
16 Reads

A case report of brain abscess caused by in a diabetic patient.

JMM Case Rep 2018 Sep 10;5(9):e005133. Epub 2018 Jan 10.

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Introduction: are Gram-positive partially acid-fast bacilli capable of inducing a wide range of infections in patients with immunodeficiency, AIDS, cancer, lupus erythematous and diabetes. was first isolated in 2001 from a patient with chronic bronchitis. Since then, there have been reports on the clinical significance of this organism in patients with bronchitis, brain abscess and lung diseases. Read More

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http://dx.doi.org/10.1099/jmmcr.0.005133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230754PMC
September 2018
3 Reads

Characterization of Streptococcus pluranimalium from a cattle with mastitis by whole genome sequencing and functional validation.

BMC Microbiol 2018 Nov 12;18(1):182. Epub 2018 Nov 12.

College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China.

Background: Streptococcus pluranimalium is a new member of the Streptococcus genus isolated from multiple different animal hosts. It has been identified as a pathogen associated with subclinical mastitis, valvular endocarditis and septicaemia in animals. Moreover, this bacterium has emerged as a new pathogen for human infective endocarditis and brain abscess. Read More

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http://dx.doi.org/10.1186/s12866-018-1327-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233522PMC
November 2018
3 Reads

Diagnosis and Treatment of Isolated Cerebral Mucormycosis: Patient-Level Data Meta-Analysis and Mayo Clinic Experience.

World Neurosurg 2018 Nov 9. Epub 2018 Nov 9.

Department of Neurology, Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin, USA.

Background: Isolated cerebral mucormycosis is a rare and serious infection associated with intravenous drug abuse.

Methods: We performed a comprehensive meta-analysis of cases reported in studies and have included an unreported case from our institution. We searched PubMed/Medline, EMBASE, Scopus, Cochrane Databases, and our institution's electronic medical health records from inception through March 31, 2018. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.218DOI Listing
November 2018
1 Read
2.420 Impact Factor

Tracheal Infection Resulting from High Endotracheal Tube Cuff Pressure in an Unconscious Patient with Brain Trauma.

Korean J Neurotrauma 2018 Oct 31;14(2):155-158. Epub 2018 Oct 31.

Department of Neurosurgery, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.

Deep neck infections (DNIs) are mainly caused by dental caries, tonsillitis, and pharyngitis; however, DNIs can also occur after head and neck trauma. A 79-year-old male patient underwent a craniectomy due to an acute subdural hematoma. The patient was unconscious and continued to have a fever, but no clear cause was found. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.13004/kjnt.2018.
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http://dx.doi.org/10.13004/kjnt.2018.14.2.155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218336PMC
October 2018
7 Reads

Intracranial Actinomycosis Manifesting as a Parenchymal Mass Lesion: A Case Report and Review of Literature.

World Neurosurg 2019 Feb 1;122:190-194. Epub 2018 Nov 1.

Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India.

Background: Intracranial actinomycosis is a rare bacterial infection with no characteristic clinical or radiologic diagnostic features. The usual presentation is similar to pyogenic brain abscess or osteomyelitis with or without pachymeningitis. Intracranial actinomycosis rarely manifests as a parenchymal mass lesion. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.10.134DOI Listing
February 2019
4 Reads
2.420 Impact Factor

Brain Abscess Showing a Lack of Restricted Diffusion and Successfully Treated with Linezolid.

Brain Tumor Res Treat 2018 Oct;6(2):92-96

Department of Neurosurgery, Eulji University, Nowon Eulji Medical Center, Seoul, Korea.

A 59-year-old patient with a history of hepatocellular carcinoma presented with decreased consciousness and left hemiparesis. A rim-enhanced mass lesion without diffusion restriction was observed in contrast-enhanced MRI including diffusion-weighted imaging. Based on these findings, metastatic brain tumor was suspected. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212685PMC
October 2018
2 Reads

Clinical Presentation and Cranial MRI Findings of Listeria monocytogenes Encephalitis: A Literature Review of Case Series.

Neurologist 2018 Nov;23(6):198-203

Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Istanbul Medeniyet University, Kadikoy.

Background: Listeria monocytogenes-associated encephalitis is a severe clinical condition that can also be seen in immunocompetent patients. Clinical manifestation and radiologic features of this entity need to be elaborated.

Review Summary: We searched the medical literature during the period spanning from 1991 to 2017 using the keyword "listeria AND [abscess odds ratio (OR) brainstem OR encephalit* OR magnetic* OR imaging*]. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000212DOI Listing
November 2018
8 Reads

Brain abscess caused by Micrococcus luteus in a patient with systemic lupus erythematosus: case-based review.

Authors:
Funda Erbasan

Rheumatol Int 2018 Dec 29;38(12):2323-2328. Epub 2018 Oct 29.

Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Akdeniz University, Antalya, Turkey.

Central nervous system infections, which are rarely seen in systemic lupus erythematosus (SLE), have considerably high mortality but they are difficult to distinguish from neuropsychiatric manifestation of lupus. This article reports the case of a patient with SLE with brain abscess which developed during immunosuppressive therapy for lupus nephritis. The patient completely recovered without neurological sequelae by open surgical drainage and 12-week antibiotic therapy. Read More

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http://dx.doi.org/10.1007/s00296-018-4182-2DOI Listing
December 2018
2 Reads