3,955 results match your criteria Brain : a journal of neurology[Journal]


Clinical and radiological differences between patients with probable cerebral amyloid angiopathy and mixed cerebral microbleeds.

J Neurol 2020 Jul 8. Epub 2020 Jul 8.

Department of Neurology, University of Schleswig-Holstein, Campus Kiel, Arnold-Heller-Str. 3, Haus D, 24105, Kiel, Germany.

Background: The key imaging features of cerebral amyloid angiopathy (CAA) are lobar, cortical, or cortico-subcortical microbleeds, macrohaemorrhages and cortical superficial siderosis (cSS). In contrast, hypertensive angiopathy is characterized by (micro) haemorrhages in the basal ganglia, thalami, periventricular white matter or the brain stem. Another distinct form of haemorrhagic microangiopathy is mixed cerebral microbleeds (mixed CMB) with features of both CAA and hypertensive angiopathy. Read More

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http://dx.doi.org/10.1007/s00415-020-10038-8DOI Listing

COVID-19 reveals influence of physical activity on symptom severity in hereditary spastic paraplegia.

J Neurol 2020 Jul 7. Epub 2020 Jul 7.

Donders Institute for Brain, Cognition and Behavior, Department of Rehabilitation, Center of Expertise for Parkinson and Movement Disorders, Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1007/s00415-020-10016-0DOI Listing

Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort.

J Neurol 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Background: Deep grey matter (DGM) atrophy in multiple sclerosis (MS) and its relation to cognitive and clinical decline requires accurate measurements. MS pathology may deteriorate the performance of automated segmentation methods. Accuracy of DGM segmentation methods is compared between MS and controls, and the relation of performance with lesions and atrophy is studied. Read More

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http://dx.doi.org/10.1007/s00415-020-10023-1DOI Listing

Cognitive impairment in benign multiple sclerosis: a multiparametric structural and functional MRI study.

J Neurol 2020 Jul 2. Epub 2020 Jul 2.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Introduction: The substrates of cognitive impairment in benign MS (BMS) still need to be identified. We investigated whether cognitive impairment in BMS patients is associated with specific patterns of brain structural and functional abnormalities.

Methods: Thirty-seven BMS patients (EDSS score ≤ 3. Read More

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http://dx.doi.org/10.1007/s00415-020-10025-zDOI Listing

High diagnostic value of plasma Niemann-Pick type C biomarkers in adults with selected neurological and/or psychiatric disorders.

J Neurol 2020 Jun 26. Epub 2020 Jun 26.

Neurology Department, Reference Center for Lysosomal Diseases, Neurogenetics and Metabolism Unit, Hôpital Pitié-Salpêtrière, 47-83 boulevard de l'Hôpital, 75013, Paris, France.

Late-onset Niemann-Pick type C (NP-C) is a rare, underdiagnosed lysosomal disease with neurological manifestations. A specific treatment, miglustat, can stabilize the disease if given early. Recently, three plasma screening biomarkers (PSBs) were developed [cholestane3β,5α,6βtriol (C-triol), 7-ketocholesterol (7-KC), and lysosphingomyelin-509 (LSM-509)], allowing a simpler and quite robust screening of patients suitable for genetic testing. Read More

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http://dx.doi.org/10.1007/s00415-020-10020-4DOI Listing

Characteristics and clinical course of Covid-19 patients admitted with acute stroke.

J Neurol 2020 Jun 24. Epub 2020 Jun 24.

Department of Stroke and Neuroscience, Charing Cross Hospital, Imperial College London NHS Healthcare Trust, Fulham Palace Road, London, W6 8RF, UK.

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http://dx.doi.org/10.1007/s00415-020-10012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313245PMC

Reversible Encephalopathy Syndrome (PRES) in a COVID-19 patient.

J Neurol 2020 Jun 24. Epub 2020 Jun 24.

Neurology and Stroke Unit, ASST Sette Laghi, Circolo Hospital, Viale Borri, 57, 20100, Varese, Italy.

Recently WHO has declared novel coronavirus disease 2019 (COVID-19) outbreak a pandemic. Acute respiratory syndrome seems to be the most common manifestation of COVID-19. Besides pneumonia, it has been demonstrated that SARS-CoV-2 infection affects multiple organs, including brain tissues, causing different neurological manifestations, especially acute cerebrovascular disease (ischemic and hemorrhagic stroke), impaired consciousness and skeletal muscle injury. Read More

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http://dx.doi.org/10.1007/s00415-020-10001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312113PMC

Olfactory testing does not predict β-amyloid, MRI measures of neurodegeneration or vascular pathology in the British 1946 birth cohort.

J Neurol 2020 Jun 24. Epub 2020 Jun 24.

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3BG, UK.

Objective: To explore the value of olfactory identification deficits as a predictor of cerebral β-amyloid status and other markers of brain health in cognitively normal adults aged ~ 70 years.

Methods: Cross-sectional observational cohort study. 389 largely healthy and cognitively normal older adults were recruited from the MRC National Survey of Health and Development (1946 British Birth cohort) and investigated for olfactory identification deficits, as measured by the University of Pennsylvania Smell Identification Test. Read More

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http://dx.doi.org/10.1007/s00415-020-10004-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311798PMC

Early cognitive and emotional outcome after stroke is independent of discharge destination.

J Neurol 2020 Jun 24. Epub 2020 Jun 24.

Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands.

Background And Purpose: Cognitive and emotional problems occur frequently after stroke. Patients with minor stroke are more likely to be discharged home. This paper compares early cognitive and emotional outcomes in patients discharged home after stroke versus patients discharged to inpatient rehabilitation, and examines the effect of cognitive and emotional outcomes on long-term participation. Read More

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http://dx.doi.org/10.1007/s00415-020-09999-7DOI Listing

Using patient-reported symptoms of dyspnea for screening reduced respiratory function in patients with motor neuron diseases.

J Neurol 2020 Jun 23. Epub 2020 Jun 23.

Department of Rehabilitation, Physical Therapy Science and Sports, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Background: Poor monitoring of respiratory function may lead to late initiation of non-invasive ventilation (NIV) in patients with motor neuron diseases (MND). Monitoring could be improved by remotely assessing hypoventilation symptoms between clinic visits. We aimed to determine which patient-reported hypoventilation symptoms are best for screening reduced respiratory function in patients with MND, and compared them to the respiratory domain of the amyotrophic lateral sclerosis functional rating scale (ALSFRS-R). Read More

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http://dx.doi.org/10.1007/s00415-020-10003-5DOI Listing

"Myo-neuropathy" is commonly associated with mitochondrial tRNA mutation.

J Neurol 2020 Jun 23. Epub 2020 Jun 23.

Research Institute of Neuromuscular and Neurodegenerative Diseases and Department of Neurology, Qilu Hospital, Shandong University, Jinan, 250000, Shandong, China.

The mitochondrial tRNA (mt-tRNA) mutation is initially associated with myoclonic epilepsy and ragged-red fibers (MERRF). The clinical, laboratory, morphologic and molecular findings from 22 mt-tRNA mutation carriers from local database in East China were analyzed retrospectively. We identified 13 symptomatic and 9 asymptomatic individuals with a known pathogenic mitochondrial tRNA mutation. Read More

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http://dx.doi.org/10.1007/s00415-020-10017-zDOI Listing

Late-onset post-lesional paroxysmal hypothermia: a case series and literature review.

J Neurol 2020 Jun 22. Epub 2020 Jun 22.

Department of Functional Neurology and Epileptology, Neurological Hospital, Hospices Civils de Lyon and University of Lyon, 59 Boulevard Pinel, 69677, Bron Cedex, Lyon, France.

Background: Paroxysmal hypothermia (PH) is a rare condition characterized by recurrent episodes of spontaneous hypothermia, bradycardia, disorders of consciousness and, in some cases, hyperhidrosis. When associated with a detectable hypothalamic lesion, PH episodes usually occur shortly after the brain insult.

Methods: We performed a retrospective study to identify patients who had demonstrated at least one episode of symptomatic spontaneous PH as defined by (i) tympanic temperature < 35 °C; (ii) drowsiness and/or confusion state and/or coma; (iii) duration of the episode ≥ 24 h; (iv) absence of other condition resulting in hypothermia RESULTS: Among 8824 patients, we identified four patients with recurrent late-onset PH episodes of 1-26-day duration that occurred 6-46 years after the brain insult. Read More

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http://dx.doi.org/10.1007/s00415-020-10013-3DOI Listing

Features of intracranial hemorrhage in cerebral venous thrombosis.

J Neurol 2020 Jun 22. Epub 2020 Jun 22.

Stroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, 245 Burgundy Street, Heidelberg, VIC, 3084, Australia.

Background: Cerebral venous thrombosis (CVT) is associated with intracranial hemorrhage.

Aim: To identify clinical and imaging features of CVT-associated intracranial hemorrhage. We hypothesized that higher clot burden would be associated with a higher risk of intracranial hemorrhage. Read More

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http://dx.doi.org/10.1007/s00415-020-10008-0DOI Listing

Clinico-radiological dissociation of disease activity in MS patients: frequency and clinical relevance.

J Neurol 2020 Jun 20. Epub 2020 Jun 20.

Department of Radiology and Nuclear Medicine, Amsterdam UMC, Location VU University Medical Center, Amsterdam, The Netherlands.

Objective: To investigate the prevalence and clinical relevance regarding disability progression in multiple sclerosis patients with a dissociation in clinical and radiological disease expression.

Methods: We prospectively selected patients with early relapsing-remitting multiple sclerosis (MS) or a clinically isolated syndrome (CIS) from the Amsterdam MS cohort. Patients underwent clinical examination at baseline, after 2 years, 6 years and a subset also after 11 years, including the Expanded Disability Status Scale (EDSS), 25-foot walk test (25-FWT) and 9-hole peg test (9-HPT). Read More

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http://dx.doi.org/10.1007/s00415-020-09991-1DOI Listing

Midlife alcohol consumption and longitudinal brain atrophy: the PREVENT-Dementia study.

J Neurol 2020 Jun 20. Epub 2020 Jun 20.

Centre for Dementia Prevention, University of Edinburgh, Edinburgh, UK.

Background And Aims: Consensus is lacking on whether light to moderate consumption of alcohol compared to abstinence is neuroprotective. In this study, we investigated the relationship between self-reported alcohol use and brain volume change over 2 years in middle-aged subjects.

Methods: A sample of 162 subjects (aged 40-59 at baseline) from the PREVENT-Dementia programme underwent MRI scans on two separate occasions (mean interval 734 days; SD 42 days). Read More

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http://dx.doi.org/10.1007/s00415-020-10000-8DOI Listing

Using amyloid PET imaging to diagnose Alzheimer's disease in patients with multiple sclerosis.

J Neurol 2020 Jun 18. Epub 2020 Jun 18.

Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, W6 8RP, UK.

Background: Cognitive dysfunction affects 40-60% of individuals with multiple sclerosis (MS). The neuropsychological profile commonly consists of a subcortical pattern of deficits, although a proportion of patients have a severe progressive cortical dementia. However, patients with MS can be affected by other neurodegenerative diseases, such as Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.1007/s00415-020-09969-zDOI Listing

Change over time in ability to perform activities of daily living in myotonic dystrophy type 1.

J Neurol 2020 Jun 15. Epub 2020 Jun 15.

Department of Neuropediatrics and Muscle Disorders, Medical Centre, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objective: The objective of this longitudinal, observational study was to investigate change over time in ability to perform activities of daily living in myotonic dystrophy type 1 (DM1).

Methods: Adults with genetically confirmed DM1 were recruited as part of the PhenoDM1 study in the UK. Data on activities of daily living were recorded through the DM1-Activ at baseline and a follow-up visit after 12 (± 3) months. Read More

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http://dx.doi.org/10.1007/s00415-020-09970-6DOI Listing

Mild traumatic brain injury recovery: a growth curve modelling analysis over 2 years.

J Neurol 2020 Jun 13. Epub 2020 Jun 13.

Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, UK.

Background: An improved understanding of the trajectory of recovery after mild traumatic brain injury is important to be able to understand individual patient outcomes, for longitudinal patient care and to aid the design of clinical trials.

Objective: To explore changes in health, well-being and cognition over the 2 years following mTBI using latent growth curve (LGC) modelling.

Methods: Sixty-one adults with mTBI presenting to a UK Major Trauma Centre completed comprehensive longitudinal assessment at up to five time points after injury: 2 weeks, 3 months, 6 months, 1 year and 2 years. Read More

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http://dx.doi.org/10.1007/s00415-020-09979-xDOI Listing

Refractory anti-NMDAR encephalitis successfully treated with bortezomib and associated movements disorders controlled with tramadol: a case report with literature review.

J Neurol 2020 Jun 13. Epub 2020 Jun 13.

Neurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a potentially fatal autoimmune disease, characterized by autoantibody-mediated neurotransmission impairment in multiple brain locations. The course of this condition often comprises altered mental status, autonomic dysfunctions, refractory seizures and hyperkinetic movement disorders. Available disease-modifying therapies include corticosteroids, i. Read More

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http://dx.doi.org/10.1007/s00415-020-09988-wDOI Listing

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis.

J Neurol 2020 Jun 13. Epub 2020 Jun 13.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background: Perivascular spaces can become detectable on magnetic resonance imaging (MRI) upon enlargement, referred to as enlarged perivascular spaces (EPVS) or Virchow-Robin spaces. EPVS have been linked to small vessel disease. Some studies have also indicated an association of EPVS to neuroinflammation and/or neurodegeneration. Read More

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http://dx.doi.org/10.1007/s00415-020-09971-5DOI Listing

Smoking and multiple sclerosis risk: a Mendelian randomization study.

J Neurol 2020 Jun 11. Epub 2020 Jun 11.

Department of Neurosciences, Laboratory for Neuroimmunology, KU Leuven, Herestraat 49 bus 1022, 3000, Leuven, Belgium.

Background: Striking changes in the demographic pattern of multiple sclerosis (MS) strongly indicate an influence of modifiable exposures, which lend themselves well to intervention. It is important to pinpoint which of the many environmental, lifestyle, and sociodemographic changes that have occurred over the past decades, such as higher smoking and obesity rates, are responsible. Mendelian randomization (MR) is an elegant tool to overcome limitations inherent to observational studies and leverage human genetics to inform prevention strategies in MS. Read More

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http://dx.doi.org/10.1007/s00415-020-09980-4DOI Listing

Clinical manifestations and evidence of neurological involvement in 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis.

J Neurol 2020 Jun 11. Epub 2020 Jun 11.

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277, Jiefang Avenue, Wuhan, 430022, Hubei Province, China.

Background: Coronavirus disease 2019 (COVID-19) has become a global pandemic, affecting millions of people. However, clinical research on its neurological manifestations is thus far limited. In this study, we aimed to systematically collect and investigate the clinical manifestations and evidence of neurological involvement in COVID-19. Read More

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http://dx.doi.org/10.1007/s00415-020-09974-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288253PMC

Dyspnea after subthalamic deep brain stimulation in Parkinson's disease: a case-control study.

J Neurol 2020 Jun 10. Epub 2020 Jun 10.

Movement Disorders Unit, Division of Neurology, CHU Grenoble Alpes, Grenoble, France.

Objective: Dyspnea can be present as non-motor symptom in patients with Parkinson's disease (PD). Deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor and non-motor symptoms in PD. However, new-onset dyspnea has been reported after DBS surgery. Read More

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http://dx.doi.org/10.1007/s00415-020-09976-0DOI Listing

Platelet function/reactivity testing and prediction of risk of recurrent vascular events and outcomes after TIA or ischaemic stroke: systematic review and meta-analysis.

J Neurol 2020 Jun 9. Epub 2020 Jun 9.

Department of Neurology, The Adelaide and Meath Hospital, Dublin, Incorporating the National Children's Hospital (AMNCH)/Tallaght University Hospital, Dublin, Ireland.

Background: The prevalence of ex vivo 'high on-treatment platelet reactivity (HTPR)' and its relationship with recurrent vascular events/outcomes in patients with ischaemic cerebrovascular disease (CVD) is unclear.

Methods: A systematic review and meta-analysis was performed in accordance with the PRISMA statement. MEDLINE, EMBASE and Cochrane Library were searched for completed manuscripts until May 2019 on TIA/ischaemic stroke patients, ≥ 18 years, treated with commonly-prescribed antiplatelet therapy, who had platelet function/reactivity testing and prospective follow-up data on recurrent stroke/TIA, myocardial infarction, vascular death or other cerebrovascular outcomes. Read More

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http://dx.doi.org/10.1007/s00415-020-09932-yDOI Listing

Multifocal laminar cortical brain lesions: a consistent MRI finding in neuro-COVID-19 patients.

J Neurol 2020 Jun 6. Epub 2020 Jun 6.

Department of Neuroradiology, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Via Olgettina 60, 20132, Milan, Italy.

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http://dx.doi.org/10.1007/s00415-020-09966-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275660PMC

Acute convexity subarachnoid hemorrhage (cSAH) in infectious endocarditis (IE): imaging features and follow-up.

J Neurol 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Bichat Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France.

Aim: To assess: (1) the prevalence of convexity subarachnoid hemorrhage (cSAH) in infective endocarditis (IE); (2) its relationship with IE features; (3) the associated lesions; (4) whether cSAH is a predictor of future hemorrhage; (5) whether cSAH could cause cortical superficial siderosis (cSS).

Methods: We retrospectively evaluated the MRI data in 240 IE-patients: At baseline, the location of cSAH and associated lesions; at follow-up, the occurrence of new lesions and of cSS. Patients with and without cSAH were compared. Read More

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http://dx.doi.org/10.1007/s00415-020-09953-7DOI Listing

Benign versus malignant Parkinson disease: the unexpected silver lining of motor complications.

J Neurol 2020 Jun 2. Epub 2020 Jun 2.

Department of Neurology, Gardner Family Center for Parkinson's Disease and Movement Disorders, University of Cincinnati, Cincinnati, OH, USA.

Objective: We sought to evaluate demographic, clinical, and habits/occupational variables between phenotypic extremes in Parkinson's disease (PD).

Methods: Databases from nine movement disorders centers across seven countries were retrospectively searched for subjects meeting criteria for very slowly progressive, benign, PD (bPD) and rapidly progressive, malignant, PD (mPD). bPD was defined as Hoehn and Yahr (H&Y) stage ≤ 3, normal cognitive function, and Schwab and England (S&E) score ≥ 70 after ≥ 20 years of PD (≥ 10 years if older than 60 at PD onset); mPD as H&Y > 3, S&E score < 70, and cognitive impairment within 10 years from PD onset. Read More

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http://dx.doi.org/10.1007/s00415-020-09954-6DOI Listing

Nationwide survey of 780 Japanese patients with amyotrophic lateral sclerosis: their status and expectations from brain-machine interfaces.

J Neurol 2020 Jun 1. Epub 2020 Jun 1.

Department of Neurological Diagnosis and Restoration, Osaka University Graduate School of Medicine, CoMIT, 2-2 Yamadaoka, Suita, Osaka, 913A565-0871, Japan.

Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that causes eventual death through respiratory failure unless mechanical ventilation is provided. Brain-machine interfaces (BMIs) may provide brain control supports for communication and motor function. We investigated the interests and expectations of patients with ALS concerning BMIs based on a large-scale anonymous questionnaire survey supported by the Japan Amyotrophic Lateral Sclerosis Association. Read More

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http://dx.doi.org/10.1007/s00415-020-09903-3DOI Listing

COVID-19-associated acute disseminated encephalomyelitis (ADEM).

J Neurol 2020 May 30. Epub 2020 May 30.

The Hospital of Central Connecticut, Hartford Healthcare, 100 Grand St., New Britain, CT, 06052, USA.

A 51-year-old woman with COVID-19 infection developed coma and an impaired oculocephalic response to one side. MRI of the brain demonstrated acute multifocal demyelinating lesions, and CSF testing did not identify a direct cerebral infection. High-dose steroids followed by a course of IVIG was administered, and the patient regained consciousness over the course of several weeks. Read More

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http://dx.doi.org/10.1007/s00415-020-09951-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260459PMC

BOLD signal within and around white matter lesions distinguishes multiple sclerosis and non-specific white matter disease: a three-dimensional approach.

J Neurol 2020 May 28. Epub 2020 May 28.

Neuroinnovation Program, Multiple Sclerosis & Neuroimmunology Imaging Program, Department of Neurology & Neurotherapeutics, UT Southwestern Medical Center, Dallas, TX, USA.

Multiple sclerosis (MS) diagnostic criteria are based upon clinical presentation and presence of white matter hyperintensities on two-dimensional magnetic resonance imaging (MRI) views. Such criteria, however, are prone to false-positive interpretations due to the presence of similar MRI findings in non-specific white matter disease (NSWMD) states such as migraine and microvascular disease. The coexistence of age-related changes has also been recognized in MS patients, and this comorbidity further poses a diagnostic challenge. Read More

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http://dx.doi.org/10.1007/s00415-020-09923-zDOI Listing

Different EEG brain activity in right and left handers during visually induced self-motion perception.

J Neurol 2020 May 27. Epub 2020 May 27.

Department of Neurology, University Hospital, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377, Munich, Germany.

Visually induced self-motion perception (vection) relies on visual-vestibular interaction. Imaging studies using vestibular stimulation have revealed a vestibular thalamo-cortical dominance in the right hemisphere in right handers and the left hemisphere in left handers. We investigated if the behavioural characteristics and neural correlates of vection differ between healthy left and right-handed individuals. Read More

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http://dx.doi.org/10.1007/s00415-020-09915-zDOI Listing

Risk of acute brain lesions in dizzy patients presenting to the emergency room: who needs imaging and who does not?

J Neurol 2020 May 27. Epub 2020 May 27.

Department of Neurology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

The usefulness of brain imaging studies in dizzy patients presenting to the emergency department (ED) is controversial. We aimed to assess the 'real-world' probability of ischemic stroke and other acute brain lesions (ABLs) in these patients to create an algorithm that helps decision-making on whether which and when brain imaging is needed. By reviewing medical records, we identified 610 patients presenting with dizziness, vertigo or imbalance to our university hospital's ED and receiving neurological workup. Read More

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http://dx.doi.org/10.1007/s00415-020-09909-xDOI Listing

Upbeat vertical nystagmus after brain stem cavernoma resection: a rare case of nucleus intercalatus/nucleus of roller injury.

J Neurol 2020 May 26. Epub 2020 May 26.

UMR 1253, iBrain, Université de Tours, Inserm, Tours, France.

Introduction: CNS cavernomas are a type of raspberry-shaped vascular malformations that are typically asymptomatic, but can result in haemorrhage, neurological injury, and seizures. Here, we present a rare case of a brainstem cavernoma that was surgically resected whereafter an upbeat nystagmus presented postoperatively.

Case Report: A 42-year old man presented with sudden-onset nausea, vomiting, vertigo, blurred vision, marked imbalance and difficulty swallowing. Read More

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http://dx.doi.org/10.1007/s00415-020-09891-4DOI Listing

Long-term safety and efficacy of daclizumab beta in relapsing-remitting multiple sclerosis: 6-year results from the SELECTED open-label extension study.

J Neurol 2020 May 25. Epub 2020 May 25.

Biogen, Cambridge, MA, USA.

Objective: SELECTED, an open-label extension study, evaluated daclizumab beta treatment for up to 6 years in participants with relapsing multiple sclerosis who completed the randomized SELECT/SELECTION studies. We report final results of SELECTED.

Methods: Eligible participants who completed 1-2 years of daclizumab beta treatment in SELECT/SELECTION received daclizumab beta 150 mg subcutaneously every 4 weeks for up to 6 years in SELECTED. Read More

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http://dx.doi.org/10.1007/s00415-020-09835-yDOI Listing

SPG7 mutations in amyotrophic lateral sclerosis: a genetic link to hereditary spastic paraplegia.

J Neurol 2020 May 23. Epub 2020 May 23.

Department of Human Genetics, Hannover Medical School, Carl-Neuberg-Straße 1, 30625, Hannover, Germany.

Amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP) are motor neuron diseases sharing clinical, pathological, and genetic similarities. While biallelic SPG7 mutations are known to cause recessively inherited HSP, heterozygous SPG7 mutations have repeatedly been identified in HSP and recently also in ALS cases. However, the frequency and clinical impact of rare SPG7 variants have not been studied in a larger ALS cohort. Read More

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http://dx.doi.org/10.1007/s00415-020-09861-wDOI Listing

Exergames for balance dysfunction in neurological disability: a meta-analysis with meta-regression.

J Neurol 2020 May 23. Epub 2020 May 23.

Rehabilitation Unit 'Mons. L. Novarese' Hospital, Loc. Trompone, 13040, Moncrivello, VC, Italy.

Objective: To evaluate systematically the efficacy of exergames for balance dysfunction in neurological conditions and to identify factors of exergaming protocols that may influence their effects.

Methods: We searched electronic databases for randomized clinical trials investigating the effect of commercial exergames versus alternative interventions on balance dysfunction as assessed by standard clinical scales in adults with acquired neurological disabilities. Standardized mean differences (Hedge's g) were calculated with random-effects models. Read More

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http://dx.doi.org/10.1007/s00415-020-09918-wDOI Listing

Visual hallucinations and illusions in Parkinson's disease: the role of ocular pathology.

J Neurol 2020 May 23. Epub 2020 May 23.

Neurology Department, Université Clermont-Auvergne, EA7280, Clermont-Ferrand University Hospital, Clermont-Ferrand, France.

Introduction: Whether different mechanisms, particularly ocular pathology, could lead to the emergence of visual hallucinations (VH) (defined as false perceptions with no external stimulus) versus visual illusions (VI) (defined as a misperception of a real stimulus) in Parkinson's disease (PD) remains debated. We assessed retinal, clinical and structural brain characteristics depending on the presence of VH or VI in PD.

Methods: In this case-control study, we compared retinal thickness using optical coherence tomography (OCT), between PD patients with: VI (PD-I; n = 26), VH (PD-H; n = 28), and without VI or VH (PD-C; n = 28), and assessed demographic data, disease severity, treatment, anatomical and functional visual complaints, cognitive and visuo-perceptive functions and MRI brain volumetry for each group of PD patients. Read More

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http://dx.doi.org/10.1007/s00415-020-09925-xDOI Listing

Neurofilaments in progressive multiple sclerosis: a systematic review.

J Neurol 2020 May 23. Epub 2020 May 23.

Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square Multiple Sclerosis Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.

Background: Neurofilament proteins have been extensively studied in relapsing-remitting multiple sclerosis, where they are promising biomarkers of disease activity and treatment response. Their role in progressive multiple sclerosis, where there is a particularly urgent need for improved biomarkers, is less clear. The objectives of this systematic review are to summarise the literature on neurofilament light and heavy in progressive multiple sclerosis, addressing key questions. Read More

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http://dx.doi.org/10.1007/s00415-020-09917-xDOI Listing

Riluzole prescribing, uptake and treatment discontinuation in people with amyotrophic lateral sclerosis in Scotland.

J Neurol 2020 May 23. Epub 2020 May 23.

Centre for Clinical Brain Sciences, University of Edinburgh, Chancellor's Building, 49 Little France Crescent, Edinburgh, EH16 4SB, UK.

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http://dx.doi.org/10.1007/s00415-020-09919-9DOI Listing

A novel frameshift deletion in autosomal recessive SBF1-related syndromic neuropathy with necklace fibres.

J Neurol 2020 May 22. Epub 2020 May 22.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, Queen Square, London, WC1N 3BG, UK.

Objective: To identify the genetic cause of complex neuropathy in two siblings from a consanguineous family.

Methods: The patients were recruited from our clinic. Muscle biopsy and whole-exome sequencing (WES) were performed. Read More

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http://dx.doi.org/10.1007/s00415-020-09827-yDOI Listing

A review of seizures and epilepsy following traumatic brain injury.

J Neurol 2020 May 22. Epub 2020 May 22.

Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK.

Traumatic brain injury (TBI) is one of the commonest presentations to emergency departments and is associated with seizures carrying different significance at different stages following injury. We describe the epidemiology of early and late seizures following TBI, the significance of intracranial haemorrhage of different types in the risk of later epilepsy and the gaps in current understanding of risk factors contributing to the risk of post-traumatic epilepsy (PTE). The delay from injury to epilepsy presents an opportunity to understand the mechanisms underlying changes in the brain and how they may reveal potential targets for anti-epileptogenic therapy. Read More

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http://dx.doi.org/10.1007/s00415-020-09926-wDOI Listing

Sonography of optic nerve sheath diameter identifies patients with middle cerebral artery infarction at risk of a malignant course: a pilot prospective observational study.

J Neurol 2020 May 22. Epub 2020 May 22.

Department of Neuroradiology, Saarland University Medical Center, Homburg, Germany.

Introduction: To assess the value of optic nerve sheath diameter (ONSD) measurements at different time points to predict the malignant evolution in middle cerebral artery (MCA) infarction and to investigate the relationship between ONSD and infarct volume on follow-up computed tomography (CT).

Methods: In a single-center prospective observational study, we recruited patients with MCA infarction and age- and sex-matched controls. Clinical characteristics including NationaI Institutes of Health Stroke Scale (NIHSS) and ONSD measurement were assessed during the first five days after symptom onset. Read More

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http://dx.doi.org/10.1007/s00415-020-09906-0DOI Listing

When does postural instability appear in monogenic parkinsonisms? An individual-patient meta-analysis.

J Neurol 2020 May 20. Epub 2020 May 20.

Department of Neurology, Gardner Family Center for Parkinson's Disease and Movement Disorders, University 6 of Cincinnati, Cincinnati, OH, USA.

Background: Postural instability is a disease milestone signaling advanced disease.

Objectives: To estimate the onset of postural instability in monogenic parkinsonisms.

Methods: We systematically reviewed studies (PubMed 1996-2017) in SNCA, PRKN, PINK1, DJ-1, LRRK2, ATP13A2, FBXO7, VPS35, DNAJC6, or SYNJ1-related monogenic parkinsonisms, with documented postural instability. Read More

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http://dx.doi.org/10.1007/s00415-020-09892-3DOI Listing

Stroke in patients with SARS-CoV-2 infection: case series.

J Neurol 2020 May 20. Epub 2020 May 20.

Clinical Neurology Unit, Azienda Sanitaria Universitaria Friuli Centrale, Presidio Ospedaliero Santa Maria della Misericordia, Udine, Italy.

Background: Italy is one of the most affected countries by the coronavirus disease 2019 (COVID-19). The responsible pathogen is named severe acute respiratory syndrome coronavirus (SARS-CoV-2). The clinical spectrum ranges from asymptomatic infection to severe pneumonia, leading to intensive care unit admission. Read More

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http://dx.doi.org/10.1007/s00415-020-09885-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238403PMC

Prevalence and risk factors of silent brain infarcts in patients with AF detected by 3T-MRI.

J Neurol 2020 May 14. Epub 2020 May 14.

Neurovascular Research Group, Institute of Biomedicine of Seville, IBiS/Hospital Universitario Virgen del Rocío/CSIC, University of Seville, Av. Manuel Siurot s/n, 41013, Seville, Spain.

Background: Silent brain infarcts (SBI), a finding on neuroimaging, are associated with higher risk of future stroke. Atrial Fibrillation (AF) has been previously identified as a cause of SBI.

Objectives: The aim of this study is to determine the prevalence of and risk factors for SBI in patients with AF and low-to-moderate embolic risk according to CHADS and CHADSVASc score. Read More

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http://dx.doi.org/10.1007/s00415-020-09887-0DOI Listing

The contribution of enhancing lesions in monitoring multiple sclerosis treatment: is gadolinium always necessary?

J Neurol 2020 May 12. Epub 2020 May 12.

Neurosciences Unit, Department of Medicine and Surgery, University of Parma, via Gramsci 14, 43126, Parma, Italy.

Background: MRI is highly sensitive for monitoring of disease activity and treatment efficacy in MS. Patients treated with disease modifying therapy (DMT), who experience MRI activity, including contrast-enhancing lesions (CEL) or new/enlarged T2 lesions, should be evaluated for a switch to more effective treatment. Due to recent evidence of gadolinium (Gd) accumulation in the brain after repeated administration of Gd-based contrast agents, FDA recommended to limit its use. Read More

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http://dx.doi.org/10.1007/s00415-020-09894-1DOI Listing

Progression of grey and white matter brain damage in Parkinson's disease: a critical review of structural MRI literature.

J Neurol 2020 May 6. Epub 2020 May 6.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.

The current review summarizes the current knowledge on longitudinal cortical and subcortical grey and white matter MRI findings assessed using T1-weighted and one-tensor diffusion-weighted MRI in Parkinson's disease (PD) patients. Results were reviewed according to disease duration, disease severity and cognitive impairment. The most consistent findings are those showing a progressive cortical atrophy accumulation in caudate, putamen, temporal/hippocampal, frontal and parietal areas in de novo PD cases and in the early/middle phase of the disease, with the achievement of a plateau in the later stage. Read More

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http://dx.doi.org/10.1007/s00415-020-09863-8DOI Listing

Longitudinal medication profile and cost savings in Parkinson's disease patients after bilateral subthalamic nucleus deep brain stimulation.

J Neurol 2020 May 4. Epub 2020 May 4.

Department of Neurosurgery, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore.

Introduction: Deep brain stimulation of the subthalamic nucleus (STN DBS) has been shown to reduce antiparkinsonian medication in Parkinson's disease. We aimed to investigate the changes in long-term medication profile with STN DBS.

Methods: Antiparkinsonian medication data for 56 patients were collected from as early as 3 years before STN DBS up to 10 years after. Read More

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http://dx.doi.org/10.1007/s00415-020-09741-3DOI Listing
May 2020
3.377 Impact Factor

A nerve conduction study predicts the prognosis of sporadic amyotrophic lateral sclerosis.

J Neurol 2020 May 4. Epub 2020 May 4.

Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Objective: To clarify the relationship between nerve conduction study (NCS) and prognosis in patients with amyotrophic lateral sclerosis (ALS).

Methods: We included 190 patients with sporadic ALS. We used onset age, sex, onset site (bulbar vs. Read More

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http://dx.doi.org/10.1007/s00415-020-09858-5DOI Listing

Neural mechanisms underlying state mental fatigue in multiple sclerosis: a pilot study.

J Neurol 2020 Apr 29. Epub 2020 Apr 29.

Kessler Foundation, 120 Eagle Rock Avenue, Suite 100, East Hanover, NJ, 07936-3147, USA.

Neuroimaging underpinnings of state (in the moment, transient) mental fatigue in multiple sclerosis (MS) are not well understood. The current pilot study examined the effect of state mental fatigue on brain activation (measured using functional magnetic resonance imaging [fMRI]) during conditions of varying cognitive loads of rapid information processing in persons with MS relative to healthy controls. Nineteen persons with MS and 17 healthy controls underwent fMRI scanning while performing a modified version of the Symbol Digit Modalities Test, which consisted of high and low cognitive load conditions with comparable visual stimulation. Read More

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http://dx.doi.org/10.1007/s00415-020-09853-wDOI Listing