3,663 results match your criteria Brain : a journal of neurology[Journal]


Resolution of apathy after dorsal instead of ventral subthalamic deep brain stimulation for Parkinson's disease.

J Neurol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00415-019-09232-0DOI Listing
February 2019

Deep brain stimulation of the subthalamic nucleus and the temporal discounting of primary and secondary rewards.

J Neurol 2019 Feb 14. Epub 2019 Feb 14.

Area of Neuroscience, SISSA, via Bonomea 265, 34136, Trieste, Italy.

Although deep brain stimulation of the subthalamic nucleus is an effective surgical treatment for Parkinson's disease, it may expose patients to non-motor side effects such as increased impulsivity and changes in decision-making behavior. Even if several studies have shown that stimulation of the subthalamic nucleus increases the incentive salience of food rewards in both humans and animals, temporal discounting for food rewards has never been investigated in patients who underwent STN-DBS. In this study, we measured inter-temporal choice after STN-DBS, using both primary and secondary rewards. Read More

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http://dx.doi.org/10.1007/s00415-019-09240-0DOI Listing
February 2019

Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study.

J Neurol 2019 Feb 13. Epub 2019 Feb 13.

Department of Neurology, Buffalo Neuroimaging Analysis Center, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High Street, Buffalo, NY, 142013, USA.

Background: Evidence regarding the role, if any, of dietary and lifestyle factors in the pathogenesis of multiple sclerosis (MS) is poorly understood.

Objective: To assess the effect of lifestyle-based risk factors linked to cardiovascular disease (CVD) on clinical and MRI-derived MS outcomes.

Methods: The study enrolled 175 MS or clinically isolated syndrome (CIS) patients and 42 age- and sex-matched healthy controls (HCs) who were longitudinally followed for 5. Read More

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http://dx.doi.org/10.1007/s00415-019-09208-0DOI Listing
February 2019
2 Reads

Frequent central nervous system, pachymeningeal and plexus MRI changes in POEMS syndrome.

J Neurol 2019 Feb 12. Epub 2019 Feb 12.

MRC Centre for Neuromuscular Diseases, National Hospital for Neurology and Neurosurgery, London, UK.

Objective: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome is a rare multisystem disease associated with a plasma-cell dyscrasia. Although pachymeningeal involvement has occasionally been described, MRI of the central nervous system (CNS) has not yet been extensively investigated.

Methods: We retrospectively evaluated CNS MRI in Europe's largest single-center cohort of POEMS syndrome. Read More

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http://link.springer.com/10.1007/s00415-019-09233-z
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http://dx.doi.org/10.1007/s00415-019-09233-zDOI Listing
February 2019
6 Reads

Sleep disturbances are common in patients with autoimmune encephalitis.

J Neurol 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.

Objectives: Autoimmune encephalitis (AE) is increasingly recognized as an important cause of subacute cognitive decline, seizures, and encephalopathy, with an ever-broadening clinical phenotype. Sleep disturbances are reported in AE patients, including rapid eye movement sleep behavior disorder, hypersomnia, fragmented sleep, and sleep-disordered breathing; however, the prevalence of sleep disturbances and contributions to outcomes in AE patients remain unknown. There is a need to determine the prevalence of sleep disturbances in AE patients, and to clarify the relationship between specific autoantibodies and disruptions in sleep. Read More

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http://dx.doi.org/10.1007/s00415-019-09230-2DOI Listing
February 2019
1 Read

Effectiveness and feasibility of cilostazol in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.

J Neurol 2019 Feb 9. Epub 2019 Feb 9.

Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: Delayed cerebral ischemia seriously affects the prognosis of patients surviving the initial aneurysmal subarachnoid hemorrhage. Application of cilostazol was reported to ameliorate vasospasm and improve outcomes in series and clinical trials. But the effectiveness and feasibility of cilostazol on aneurysmal subarachnoid hemorrhage remained controversial. Read More

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http://link.springer.com/10.1007/s00415-019-09198-z
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http://dx.doi.org/10.1007/s00415-019-09198-zDOI Listing
February 2019
2 Reads

Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke.

J Neurol 2019 Feb 9. Epub 2019 Feb 9.

Department of Neurology, Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Background And Aims: Previously, microvascular cerebral blood flow (CBF) response to a mild head-of-bed (HOB) elevation has been shown to be altered in acute ischemic stroke (AIS) by diffuse correlation spectroscopy (DCS). We have hypothesized that early CBF response is related to the functional outcome.

Methods: Patients with a non-lacunar AIS in the anterior circulation were monitored by DCS to measure relative CBF (ΔrCBF) on the frontal lobes bilaterally during a 0°-30° HOB elevation at early (≤ 12) or late (> 12) hours from symptom onset. Read More

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http://dx.doi.org/10.1007/s00415-019-09226-yDOI Listing
February 2019

Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients.

J Neurol 2019 Feb 1. Epub 2019 Feb 1.

Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.

This study systematically investigated the neuropsychological profile of language disturbance in frontotemporal dementia-motor neuron disease (FTD-MND) using a data-driven approach. Neuroanatomical correlates of language profiles were also examined. Patients with FTD-MND (N = 26), pure motor neuron disease (N = 34), progressive non-fluent aphasia (N = 30), semantic dementia (N = 17), and controls (N = 31) underwent comprehensive language assessments. Read More

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http://dx.doi.org/10.1007/s00415-019-09216-0DOI Listing
February 2019
1 Read

Prospective association between adherence to the MIND diet and subjective memory complaints in the French NutriNet-Santé cohort.

J Neurol 2019 Jan 31. Epub 2019 Jan 31.

Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), Centre d'Epidémiologie et Statistiques Sorbonne Paris Cité, Université Paris 13, Inserm (U1153), Cnam, Inra (U1125), COMUE Sorbonne Paris Cité, 74 rue Marcel Cachin, 93017, Bobigny, France.

Objectives: Our objective was to examine whether adherence to the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) was associated with SMC (as measured by the cognitive difficulties scale; CDS) in the NutriNet-Santé cohort.

Methods: The study sample consisted of 6011 participants aged ≥ 60 years at baseline, without SMC at the beginning. SMC were defined by a CDS score ≥ 43 (corresponding to the 4th CDS quartile) and SMC cases were participants with SMC at least once during follow-up. Read More

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http://dx.doi.org/10.1007/s00415-019-09218-yDOI Listing
January 2019

Outcome after individualized stereoelectroencephalography (sEEG) implantation and navigated resection in patients with lesional and non-lesional focal epilepsy.

J Neurol 2019 Jan 30. Epub 2019 Jan 30.

Department of Neurosurgery, University Hospital of Munich, Ludwig-Maximilians-University, Marchioninistr. 15, 81377, Munich, Germany.

Background: Refined localization of the epileptogenic zone (EZ) in patients with pharmacoresistant focal epilepsy proceeding to resective surgery might improve postoperative outcome. We here report seizure outcome after stereo EEG (sEEG) evaluation with individually planned stereotactically implanted depth electrodes and subsequent tailored resection.

Methods: A cohort of consecutive patients with pharmacoresistant focal epilepsy, evaluated with a non-invasive evaluation protocol and invasive monitoring with personalized, stereotactically implanted depth electrodes for sEEG was analyzed. Read More

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http://dx.doi.org/10.1007/s00415-019-09213-3DOI Listing
January 2019

Individual parkinsonian motor signs and striatal dopamine transporter deficiency: a study with [I-123]FP-CIT SPECT.

J Neurol 2019 Jan 28. Epub 2019 Jan 28.

Division of Clinical Neurosciences, University of Turku, Turku University Hospital, POB 52, 20521, Turku, Finland.

Introduction: Total parkinsonian motor symptom severity correlates with presynaptic striatal dopamine function in patients with Parkinson's disease. There is a lack of studies that have investigated the associations between parkinsonian motor signs and striatal dopaminergic deficiency in patients with parkinsonism of an unknown origin. Identification of specific motor signs associated with the highest likelihood of striatal dopamine deficiency could aid the differential diagnostics of parkinsonian and tremor syndromes. Read More

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http://dx.doi.org/10.1007/s00415-019-09202-6DOI Listing
January 2019

Transient seizure onset network for localization of epileptogenic zone: effective connectivity and graph theory-based analyses of ECoG data in temporal lobe epilepsy.

J Neurol 2019 Jan 25. Epub 2019 Jan 25.

Department of Geriatric Medicine, Beijing Luhe Hospital, Capital Medical University, No. 82, Xinhua South Street, Tongzhou District, Beijing, 101149, China.

Objective: Abnormal and dynamic epileptogenic networks cause difficulties for clinical epileptologists in the localization of the seizure onset zone (SOZ) and the epileptogenic zone (EZ) in preoperative assessments of patients with refractory epilepsy. The aim of this study is to investigate the characteristics of time-varying effective connectivity networks in various non-seizure and seizure periods, and to propose a quantitative approach for accurate localization of SOZ and EZ.

Methods: We used electrocorticogram recordings in the temporal lobe and hippocampus from seven patients with temporal lobe epilepsy to characterize the effective connectivity dynamics at a high temporal resolution using the full-frequency adaptive directed transfer function (ffADTF) measure and five graph metrics, i. Read More

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http://link.springer.com/10.1007/s00415-019-09204-4
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http://dx.doi.org/10.1007/s00415-019-09204-4DOI Listing
January 2019
4 Reads

Deep brain stimulation for monogenic Parkinson's disease: a systematic review.

J Neurol 2019 Jan 18. Epub 2019 Jan 18.

Division of Clinical Neurosciences, Turku University Hospital, Hämeentie 11, POB 52, 20521, Turku, Finland.

Deep brain stimulation (DBS) is an effective treatment for Parkinson's disease (PD) patients with motor fluctuations and dyskinesias. The key DBS efficacy studies were performed in PD patients with unknown genotypes; however, given the estimated monogenic mutation prevalence of approximately 5-10%, most commonly LRRK2, PRKN, PINK1 and SNCA, and risk-increasing genetic factors such as GBA, proper characterization is becoming increasingly relevant. We performed a systematic review of 46 studies that reported DBS effects in 221 genetic PD patients. Read More

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http://dx.doi.org/10.1007/s00415-019-09181-8DOI Listing
January 2019
3 Reads

Painful legs and moving toes syndrome evaluated through brain single photon emission computed tomography: a case series.

J Neurol 2019 Mar 14;266(3):717-725. Epub 2019 Jan 14.

Department of Neurology, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo, 113-8431, Japan.

Painful legs and moving toes (PLMT) syndrome is a clinical entity characterized by persistent pain in the feet or legs and involuntary movements of one or more toes. The precise patho-mechanisms of PLMT still remain unknown. Herein, we examined ten patients clinically identified with PLMT syndrome. Read More

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http://dx.doi.org/10.1007/s00415-019-09194-3DOI Listing
March 2019
2 Reads

Incidence and mechanism of early neurological deterioration after endovascular thrombectomy.

J Neurol 2019 Mar 10;266(3):609-615. Epub 2019 Jan 10.

Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, 224-1, Heukseok-dong, Dongjak-gu, Seoul, 156-755, South Korea.

Background: We investigated the prevalence and mechanisms of neurological deterioration after endovascular thrombectomy.

Methods: Between January 2011 and October 2017, acute ischemic stroke patients treated by endovascular thrombectomy in a tertiary university hospital were included. Early neurological deterioration (END) was defined as an increase of 2 or more National Institute of Health Stroke Scale (NIHSS) compared to the best neurological status after stroke within 7 days. Read More

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http://link.springer.com/10.1007/s00415-018-09173-0
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http://dx.doi.org/10.1007/s00415-018-09173-0DOI Listing
March 2019
18 Reads

Continuous subcutaneous apomorphine in advanced Parkinson's disease patients treated with deep brain stimulation.

J Neurol 2019 Mar 7;266(3):659-666. Epub 2019 Jan 7.

Servicio de Neurología, Hospital Clínico Universitario Santiago de Compostela, Santiago de Compostela, Spain.

Introduction: Deep brain stimulation (DBS) is an effective therapy for patients with advanced Parkinson's disease (PD). However, sometimes, it is not sufficient to adequately control motor symptoms. We describe our experience with continuous subcutaneous apomorphine infusion (APO) in patients with DBS. Read More

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http://dx.doi.org/10.1007/s00415-019-09184-5DOI Listing
March 2019
1 Read

Atypical parkinsonism with severely reduced striatal dopamine uptake associated with a 16p11.2 duplication syndrome.

J Neurol 2019 Mar 7;266(3):775-776. Epub 2019 Jan 7.

Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research (HIH), University of Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.

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http://link.springer.com/10.1007/s00415-019-09182-7
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http://dx.doi.org/10.1007/s00415-019-09182-7DOI Listing
March 2019
8 Reads

Neurological update: MOG antibody disease.

J Neurol 2018 Dec 19. Epub 2018 Dec 19.

Division of Psychological Medicine and Clinical Neurosciences, Cardiff University School of Medicine, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.

Myelin oligodendrocyte glycoprotein (MOG) antibody disease (MOG-AD) is now recognised as a nosological entity with specific clinical and paraclinical features to aid early diagnosis. Although no age group is exempt, median age of onset is within the fourth decade of life, with optic neuritis being the most frequent presenting phenotype. Disease course can be either monophasic or relapsing, with subsequent relapses most commonly involving the optic nerve. Read More

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http://dx.doi.org/10.1007/s00415-018-9122-2DOI Listing
December 2018
1 Read

Patient characteristics and outcome associations in AMPA receptor encephalitis.

J Neurol 2019 Feb 17;266(2):450-460. Epub 2018 Dec 17.

Department of Neurology, Washington University in St. Louis, Saint Louis, MO, USA.

Antibody-mediated encephalitis defines a class of diseases wherein antibodies directed at cell-surface receptors are associated with behavioral and cognitive disturbances. One such recently described encephalitis is due to antibodies directed at alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPAR). This entity is exceptionally rare and its clinical phenotype incompletely described. Read More

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http://dx.doi.org/10.1007/s00415-018-9153-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367044PMC
February 2019
2 Reads

Clinical and economic comparison of an individualised immunoglobulin protocol vs. standard dosing for chronic inflammatory demyelinating polyneuropathy.

J Neurol 2019 Feb 17;266(2):461-467. Epub 2018 Dec 17.

Regional Neuromuscular Service, University Hospitals Birmingham, Birmingham, UK.

Background: The clinical and economic implications of an individualised intravenous immunoglobulin (IVIg) protocol for chronic inflammatory demyelinating polyneuropathy (CIDP) are unknown. Comparison with standard dosing regimens has not been performed.

Methods: We retrospectively studied 47 IVIg-treated subjects with CIDP over 4 years with an individualised, outcome-measured, dose-modifying protocol. Read More

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http://dx.doi.org/10.1007/s00415-018-9157-4DOI Listing
February 2019
1 Read

Clinical feasibility of 1-min ultrafast brain MRI compared with routine brain MRI using synthetic MRI: a single center pilot study.

J Neurol 2019 Feb 7;266(2):431-439. Epub 2018 Dec 7.

MR Applications and Workflow, GE Healthcare Korea, 343 Hakdong-ro, Gangnam-gu, Seoul, 06060, Republic of Korea.

Background: Ultrafast brain MRI is required for uncooperative patients and time-critical diseases such as stroke because it reduces scan times and motion artifacts. This study investigated the clinical feasibility of a 1-min ultrafast brain MRI protocol for detecting intracranial abnormalities in restless and uncooperative patients.

Methods: We retrospectively reviewed the records of 25 patients who underwent a 1-min ultrafast MRI protocol using T1-weighted image, T2-weighted image, echo-planar fluid-attenuated inversion recovery, diffusion-weighted image, and T2*-weighted image between March 2017 and May 2017. Read More

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http://dx.doi.org/10.1007/s00415-018-9149-4DOI Listing
February 2019
3 Reads
3.377 Impact Factor

Gait festination in parkinsonism: introduction of two phenotypes.

J Neurol 2019 Feb 7;266(2):426-430. Epub 2018 Dec 7.

Department of Neurology, Centre of Clinical Neuroscience, First Faculty of Medicine, General University Hospital, Charles University, Prague, Czech Republic.

Gait festination is one of the most characteristic gait disturbances in patients with Parkinson's disease or atypical parkinsonism. Although festination is common and disabling, it has received little attention in the literature, and different definitions exist. Here, we argue that there are actually two phenotypes of festination. Read More

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http://dx.doi.org/10.1007/s00415-018-9146-7DOI Listing
February 2019
4 Reads

The applause sign in frontotemporal lobar degeneration and related conditions.

J Neurol 2019 Feb 1;266(2):330-338. Epub 2018 Dec 1.

Neurologische Klinik und Poliklinik, Ludwig Maximilians Universität München, Munich, Germany.

The applause sign, i.e., the inability to execute the same amount of claps as performed by the examiner, was originally reported as a sign specific for progressive supranuclear palsy (PSP). Read More

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http://dx.doi.org/10.1007/s00415-018-9134-yDOI Listing
February 2019
13 Reads
3.377 Impact Factor

ANO10 mutational screening in recessive ataxia: genetic findings and refinement of the clinical phenotype.

J Neurol 2019 Feb 4;266(2):378-385. Epub 2018 Dec 4.

Unit of Medical Genetics and Neurogenetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, via Celoria 11, 20133, Milan, Italy.

Autosomal recessive cerebellar ataxia type 3 (ARCA3) is a rare inherited disorder caused by mutations in the ANO10 gene. The disease is characterized by slowly progressive spastic ataxia variably associated with motor neuron involvement, epilepsy, and cognitive decline. We performed mutational screening in 80 patients with sporadic or autosomal recessive adult-onset ataxia. Read More

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http://link.springer.com/10.1007/s00415-018-9141-z
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http://dx.doi.org/10.1007/s00415-018-9141-zDOI Listing
February 2019
9 Reads

A controlled inflammation and a regulatory immune system are associated with more favorable prognosis of progressive multifocal leukoencephalopathy.

J Neurol 2019 Feb 3;266(2):369-377. Epub 2018 Dec 3.

Department of Neurology and Neurological Science, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, 1-5-45 Yushima Bunkyo-ku, Tokyo, 113-8510, Japan.

Objective: In the present study, we analyzed the inflammatory profiles of brain tissues obtained from patients with progressive multifocal leukoencephalopathy (PML) due to John Cunningham (JC) virus infection to identify potential prognostic factors.

Methods: The study included seven patients (two men, five women) who had been pathologically diagnosed with PML, and all of whom were HIV negative. Fixed brain samples were analyzed via hematoxylin and eosin (HE) staining and Klüver-Barrera (KB) staining. Read More

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http://dx.doi.org/10.1007/s00415-018-9140-0DOI Listing
February 2019
2 Reads

Motor neuron involvement in anti-Ma2-associated paraneoplastic neurological syndrome.

J Neurol 2019 Feb 29;266(2):398-410. Epub 2018 Nov 29.

French Reference Center of Paraneoplastic Neurological Syndrome, Hospices Civils de Lyon, Hôpital Neurologique, Lyon, France.

Objective: To present clinical, radiological, and pathological features of a cohort of patients with motor neuron involvement in association with anti-Ma2 antibodies (Ma2-Ab).

Methods: Retrospective case-series of patients with definite paraneoplastic neurological syndrome (PNS) and Ma2-Ab, and cases identified from a review of the literature.

Results: Among 33 Ma2-Ab patients referred between 2002 and 2016, we retrospectively identified three patients (9. Read More

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http://dx.doi.org/10.1007/s00415-018-9143-xDOI Listing
February 2019
2 Reads

Brain tissue volumes and relaxation rates in multiple sclerosis: implications for cognitive impairment.

J Neurol 2019 Feb 29;266(2):361-368. Epub 2018 Nov 29.

Biostructure and Bioimaging Institute, National Research Council, Via De Amicis, 95, 80145, Naples, Italy.

Objective: Both normal gray matter atrophy and brain tissue relaxation rates, in addition to total lesion volume, have shown significant correlations with cognitive test scores in multiple sclerosis (MS). Aim of the study was to assess the relative contributions of macro- and microstructural changes of both normal and abnormal brain tissues, probed, respectively, by their volumes and relaxation rates, to the cognitive status and physical disability of MS patients.

Methods: MRI studies from 241 patients with relapsing-remitting MS were retrospectively analyzed by fully automated multiparametric relaxometric segmentation. Read More

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http://dx.doi.org/10.1007/s00415-018-9139-6DOI Listing
February 2019
1 Read

Different routes of heroin intake cause various heroin-induced leukoencephalopathies.

J Neurol 2019 Feb 26;266(2):316-329. Epub 2018 Nov 26.

Department of Neurology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Objective: Toxic leukoencephalopathy is a rare but critical neurological disorder in heroin abusers. Our aim is to compare the clinical manifestations, brain MRIs and prognoses of heroin-induced leukoencephalopathy by different intake routes.

Methods: We present two patients with toxic leukoencephalopathy caused by intravenous (IV) injection of heroin and 48 additional cases from systematic reviews of the literature published between 1994 and 2018. Read More

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http://dx.doi.org/10.1007/s00415-018-9131-1DOI Listing
February 2019
3 Reads
3.377 Impact Factor

Endovascular stroke treatment's impact on malignant type of edema (ESTIMATE).

J Neurol 2019 Jan 23;266(1):223-231. Epub 2018 Nov 23.

Department of Neurology, University Hospital Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany.

Background And Purpose: In patients with acute ischemic stroke and large vessel occlusion, the prognosis has improved tremendously since the implementation of endovascular thrombectomy (EVT). The effect of EVT on the incidence of malignant middle cerebral artery infarctions (MMI) has not been studied before.

Methods: ESTIMATE, a multicenter retrospective study, evaluates data of ischemic stroke patients with occlusion in the anterior circulation in the years of 2007-2015 comparing three treatment options (no therapy; IV-TPA; IV-TPA plus EVT or EVT only). Read More

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http://dx.doi.org/10.1007/s00415-018-9127-xDOI Listing
January 2019
9 Reads

Structural network topology relates to tissue properties in multiple sclerosis.

J Neurol 2019 Jan 22;266(1):212-222. Epub 2018 Nov 22.

Department of Anatomy and Neurosciences, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Location VU University Medical Center, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.

Objective: Abnormalities in segregative and integrative properties of brain networks have been observed in multiple sclerosis (MS) and are related to clinical functioning. This study aims to investigate the micro-scale correlates of macro-scale network measures of segregation and integration in MS.

Methods: Eight MS patients underwent post-mortem in situ whole-brain diffusion tensor (DT) imaging and subsequent brain dissection. Read More

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http://dx.doi.org/10.1007/s00415-018-9130-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342882PMC
January 2019
8 Reads

An update on advances in magnetic resonance imaging of multiple system atrophy.

J Neurol 2018 Nov 20. Epub 2018 Nov 20.

Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK.

In this review, we describe how different neuroimaging tools have been used to identify novel MSA biomarkers, highlighting their advantages and limitations. First, we describe the main structural MRI changes frequently associated with MSA including the 'hot cross-bun' and 'putaminal rim' signs as well as putaminal, pontine, and middle cerebellar peduncle (MCP) atrophy. We discuss the sensitivity and specificity of different supra- and infratentorial changes in differentiating MSA from other disorders, highlighting those that can improve diagnostic accuracy, including the MCP width and MCP/superior cerebellar peduncle (SCP) ratio on T1-weighted imaging, raised putaminal diffusivity on diffusion-weighted imaging, and increased T2* signal in the putamen, striatum, and substantia nigra on susceptibility-weighted imaging. Read More

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http://dx.doi.org/10.1007/s00415-018-9121-3DOI Listing
November 2018
2 Reads

Quality of life in idiopathic dystonia: a systematic review.

J Neurol 2018 Nov 20. Epub 2018 Nov 20.

Academic Department of Neurosciences, Sheffield Teaching Hospitals, NHS Foundation Trust, Sheffield, UK.

Objective: Dystonia is characterised by sustained muscular contractions frequently producing repetitive, twisting and patterned movements. The primary aim of this systematic review was to establish how quality of life (QoL) is affected in idiopathic focal, multifocal and segmental dystonia. This review aimed to evaluate variations in QoL between different subtypes of dystonia, identify the determinants of QoL and assess the effects of different treatments on QoL. Read More

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http://dx.doi.org/10.1007/s00415-018-9119-xDOI Listing
November 2018
18 Reads

Spinal motor neurons and motor function in older adults.

J Neurol 2019 Jan 16;266(1):174-182. Epub 2018 Nov 16.

Rush Alzheimer's Disease Center, Rush University Medical Center, Jelke Building, Suite #1000; 1750 West Harrison Street, Chicago, IL, 60612, USA.

This study examined the relation between lumbar spinal motor neuron (SMN) indices and motor function proximate to death in community-dwelling older adults. Older adults (N = 145) participating in the Rush Memory and Aging Project underwent structured clinical testing proximate to death and brain and spinal cord autopsy at time of death. Ten motor performances were summarized by a composite global motor score. Read More

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http://link.springer.com/10.1007/s00415-018-9118-y
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http://dx.doi.org/10.1007/s00415-018-9118-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344292PMC
January 2019
21 Reads

Sporadic CJD in association with HIV.

J Neurol 2019 Jan 16;266(1):253-257. Epub 2018 Nov 16.

Brighton and Sussex University Hospitals Trust, Royal Sussex County Hospital, Eastern Road, Brighton, BN2 5BE, UK.

Background: Creutzfeldt-Jakob disease (CJD) is a rapidly progressive fatal neurodegenerative disorder. We report an unusual case of pathologically confirmed sporadic CJD developing in a HIV-positive patient but presenting with clinical and radiological features suggestive of variant CJD.

Case Presentation: A 63-year-old man with chronic stable HIV developed progressive difficulties with decision-making, obsessive compulsive disorder and visual hallucinations over 3 months. Read More

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http://link.springer.com/10.1007/s00415-018-9116-0
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http://dx.doi.org/10.1007/s00415-018-9116-0DOI Listing
January 2019
17 Reads

Non-invasive evaluation of cerebral perfusion in patients with transient ischemic attack: an fMRI study.

J Neurol 2019 Jan 16;266(1):157-164. Epub 2018 Nov 16.

Department of Neurology, Anshan Changda Hospital, No. 69 Changda St, Tiedong District, Anshan, 114005, Liaoning, China.

Detection of hypoperfused tissue due to the ischemia is considered to be important in understanding the cerebral perfusion status and may be helpful in guiding therapeutic decisions for patients with transient ischemic attack (TIA). We hypothesized that the combination of two non-invasive fMRI techniques: resting-state BOLD-fMRI time-shift analysis (TSA) approach and 3D ASL, could detect the cerebral hemodynamic status in TIA patients noninvasively. From April 2015 to June 2016, 51 TIA patients were recruited in this study. Read More

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http://link.springer.com/10.1007/s00415-018-9113-3
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http://dx.doi.org/10.1007/s00415-018-9113-3DOI Listing
January 2019
9 Reads

Detecting optic nerve lesions in clinically isolated syndrome and multiple sclerosis: double-inversion recovery magnetic resonance imaging in comparison with visually evoked potentials.

J Neurol 2019 Jan 16;266(1):148-156. Epub 2018 Nov 16.

Department of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

Background And Aim: Optic neuritis (ON) is a frequent manifestation of multiple sclerosis (MS), traditionally diagnosed clinically and by visually evoked potentials (VEP). However, ON can also be assessed by MRI. Here we compare the diagnostic performance of 3D-double inversion recovery-MRI (3D-DIR) and VEPs in patients with definite MS or clinically isolated syndrome (CIS). Read More

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http://link.springer.com/10.1007/s00415-018-9114-2
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http://dx.doi.org/10.1007/s00415-018-9114-2DOI Listing
January 2019
12 Reads

Amyloid-β and Parkinson's disease.

J Neurol 2018 Oct 30. Epub 2018 Oct 30.

Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience at King's College London, De Crespigny Park, London, SE5 8AF, UK.

Parkinson's disease (PD) is the second commonest neurodegenerative disorder in the world with a rising prevalence. The pathophysiology is multifactorial but aggregation of misfolded α-synuclein is considered to be a key underpinning mechanism. Amyloid-β (Aβ) and tau deposition are also comorbid associations and especially Aβ deposition is associated with cognitive decline in PD. Read More

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http://dx.doi.org/10.1007/s00415-018-9100-8DOI Listing
October 2018
2 Reads

Biological and imaging predictors of cognitive impairment after stroke: a systematic review.

J Neurol 2018 Oct 22. Epub 2018 Oct 22.

Degenerative and Vascular Cognitive Disorders, CHU Lille, Department of Neurology, Roger Salengro Hospital, University Lille, Inserm U1171, 59000, Lille, France.

Background: Cognitive impairment is frequent after stroke, and several studies have suggested that biological and imaging characteristics present before stroke are associated with the development of post-stroke cognitive impairment.

Objective: The aim of our study was to systematically review biological and imaging predictors of cognitive impairment after stroke.

Method: Studies were identified from bibliographic databases and reference lists, and were included if conducted in patients with acute stroke, with at least 30 patients, and a follow-up of at least 3 months. Read More

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http://link.springer.com/10.1007/s00415-018-9089-z
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http://dx.doi.org/10.1007/s00415-018-9089-zDOI Listing
October 2018
17 Reads

Early MRI-negative posterior circulation stroke presenting as acute dizziness.

J Neurol 2018 Dec 19;265(12):2993-3000. Epub 2018 Oct 19.

Department of Neurology, College of Medicine, Pusan National University Hospital, Pusan National University School of Medicine and Biomedical Research Institute, 179, Gudeok-ro, Seo-gu, 602-739, Busan, South Korea.

The aim of this study was to determine the frequency, clinical and radiological features, and efficacy of clinical evaluation and perfusion-weighted imaging (PWI) for the prediction of final stroke in patients with DWI/MRI-negative posterior circulation stroke (PCS) presenting acute dizziness/vertigo. From our comprehensive prospective stroke registry of acute ischemic stroke during a 7-year period, we identified 1846 consecutive patients with PCS, 850 of whom presented with acute dizziness/vertigo. Of these 850 patients, initial DWI-MRI was negative in 35 (4. Read More

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http://link.springer.com/10.1007/s00415-018-9097-z
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http://dx.doi.org/10.1007/s00415-018-9097-zDOI Listing
December 2018
10 Reads

Perfusion-CT imaging in epileptic seizures.

J Neurol 2018 Dec 16;265(12):2972-2979. Epub 2018 Oct 16.

Service of Neurology, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.

Introduction: PCT is used in the diagnosis of acute neurological syndromes, particularly stroke. We aimed to evaluate PCT abnormalities in patients with acute epileptic seizures or status epilepticus (SE).

Methods: We collected patients undergoing acute PCT for the suspicion of acute ischemic stroke (AIS), who received a final diagnosis of focal seizures or generalised seizures with a post-ictal deficit, with or without concomitant AIS. Read More

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http://dx.doi.org/10.1007/s00415-018-9095-1DOI Listing
December 2018
10 Reads

Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series.

J Neurol 2018 Dec 15;265(12):2960-2971. Epub 2018 Oct 15.

Department of Neurology, Memory and Aging Center, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA, 94158, USA.

Objectives: To determine the clinical, anatomical, genetic and pathological features of dual frontotemporal lobar degeneration (FTLD) pathology: FTLD-tau and FTLD-TDP-43 in a large clinicopathological cohort.

Methods: We selected subjects with mixed FTLD-TDP and FTLD-tau from 247 FTLD cases from the University of California, San Francisco, Neurodegenerative Disease Brain Bank collected between 2000 and 2016 and compared their clinical, anatomical, genetic, imaging and pathological signatures with those of subjects with pure FTLD.

Results: We found nine cases (3. Read More

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http://link.springer.com/10.1007/s00415-018-9086-2
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http://dx.doi.org/10.1007/s00415-018-9086-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245666PMC
December 2018
12 Reads

Structural signature in SCA1: clinical correlates, determinants and natural history.

J Neurol 2018 Dec 15;265(12):2949-2959. Epub 2018 Oct 15.

Department of Neurology, University of Campinas (UNICAMP), R. Tessália Vieira de Camargo, 126, Campinas, 13083-887, Brazil.

Spinocerebellar ataxia type 1 is an autosomal dominant disorder caused by a CAG repeat expansion in ATXN1, characterized by progressive cerebellar and extracerebellar symptoms. MRI-based studies in SCA1 focused in the cerebellum and connections, but there are few data about supratentorial/spinal damage and its clinical relevance. We have thus designed this multimodal MRI study to uncover the structural signature of SCA1. Read More

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http://dx.doi.org/10.1007/s00415-018-9087-1DOI Listing
December 2018
7 Reads

The role of clinical and neuroimaging features in the diagnosis of CADASIL.

J Neurol 2018 Dec 11;265(12):2934-2943. Epub 2018 Oct 11.

Neurology Unit, Department of Neuroscience and Sensory Organs, Maggiore Policlinico Hospital Foundation IRCCS Ca' Granda, Milan, Italy.

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL.

Methods: Patients with lacunar stroke or TIA were included in the present study. Read More

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http://link.springer.com/10.1007/s00415-018-9072-8
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http://dx.doi.org/10.1007/s00415-018-9072-8DOI Listing
December 2018
14 Reads
3.380 Impact Factor

The clinical features and outcome of scan-negative and scan-positive cases in suspected cauda equina syndrome: a retrospective study of 276 patients.

J Neurol 2018 Dec 8;265(12):2916-2926. Epub 2018 Oct 8.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Background: The majority of patients presenting with suspected clinical cauda equina syndrome (CES) have no identifiable structural cause for their symptoms ('scan-negative' CES). Understanding these patients aids clinical differentiation and management in CES.

Methods: A retrospective electronic note review was undertaken of patients presenting with suspected CES, defined as ≥ 1 of acute bladder, bowel, sexual dysfunction or saddle numbness, to a regional neurosciences centre. Read More

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http://dx.doi.org/10.1007/s00415-018-9078-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244667PMC
December 2018
4 Reads

Management of patients with stroke treated with direct oral anticoagulants.

J Neurol 2018 Dec 6;265(12):3022-3033. Epub 2018 Oct 6.

Neurology and Stroke Center, Department of Clinical Research, University Hospital and University of Basel, Petersgraben 4, 4031, Basel, Switzerland.

Since their market approval, direct oral anticoagulants (DOACs) are being increasingly used for stroke prevention in patients with atrial fibrillation. However, the management of DOAC-treated patients with stroke poses several challenges for physicians in everyday clinical practice, both in the acute setting and in long-term care. This has spurred extensive research activity in the field over the past few years, which we review here. Read More

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http://link.springer.com/10.1007/s00415-018-9061-y
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http://dx.doi.org/10.1007/s00415-018-9061-yDOI Listing
December 2018
19 Reads

Comparison of outcome in stroke patients admitted during working hours vs. off-hours; a single-center cohort study.

J Neurol 2019 Mar 5;266(3):782-789. Epub 2018 Oct 5.

Department of neurology, Medisch Spectrum Twente, Koningsplein 1, 7512KZ, Enschede, The Netherlands.

Introduction: We aimed to disprove an in-hospital off-hour effect in stroke patients by adjusting for disease severity and poor prognostic findings on imaging.

Patients And Methods: Our study included 5378 patients from a single center prospective stroke registry of a large teaching hospital in the Netherlands, admitted between January 2003 and June 2015. Patients were categorized by admission time, off-hours (OH) or working hours (WH). Read More

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http://dx.doi.org/10.1007/s00415-018-9079-1DOI Listing
March 2019
1 Read

Spinocerebellar ataxia: an update.

J Neurol 2019 Feb 3;266(2):533-544. Epub 2018 Oct 3.

Department of Neuromuscular Diseases, UCL Queen's Square Institute of Neurology, Queen's Square House, Queen's Square, London, WC1N 3BG, UK.

Spinocerebellar ataxia (SCA) is a heterogeneous group of neurodegenerative ataxic disorders with autosomal dominant inheritance. We aim to provide an update on the recent clinical and scientific progresses in SCA where numerous novel genes have been identified with next-generation sequencing techniques. The main disease mechanisms of these SCAs include toxic RNA gain-of-function, mitochondrial dysfunction, channelopathies, autophagy and transcription dysregulation. Read More

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http://link.springer.com/10.1007/s00415-018-9076-4
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http://dx.doi.org/10.1007/s00415-018-9076-4DOI Listing
February 2019
3 Reads

Relation between functional connectivity and disability in multiple sclerosis: a non-linear model.

J Neurol 2018 Dec 1;265(12):2881-2892. Epub 2018 Oct 1.

Department of Human Neuroscience, Sapienza University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.

Objective: To characterize the relation between brain functional connectivity and disability in patients with multiple sclerosis; to investigate the existence of critical values of both disability and functional connectivity corresponding to exhaustion of functional adaptive mechanisms.

Methods: Hundred-and-nineteen patients with no-to-severe disability and 42 healthy subjects were studied via 3T resting state functional MRI. Out of 116 regions extracted from Automated Anatomical Labeling atlas, pairs of regions whose functional connectivity correlated with Expanded Disability Status Score were identified. Read More

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http://dx.doi.org/10.1007/s00415-018-9075-5DOI Listing
December 2018
13 Reads

Effect of mechanical thrombectomy alone or in combination with intravenous thrombolysis for acute ischemic stroke.

J Neurol 2018 Dec 1;265(12):2875-2880. Epub 2018 Oct 1.

Department of Systems Medicine, Comprehensive Stroke Center, University of Tor Vergata, Viale Oxford 81, 00133, Rome, Italy.

Objective And Design: Whether combining intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) is superior to mechanical thrombectomy alone for large vessel occlusion acute ischemic stroke is still uncertain. Our aim was to compare the safety and the efficacy of these two therapeutic strategies.

Materials: Patients with acute ischemic stroke secondary to anterior circulation large vessel occlusion. Read More

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http://dx.doi.org/10.1007/s00415-018-9073-7DOI Listing
December 2018
3 Reads

Gerald M. Edelman (1929-2014).

J Neurol 2018 Oct 1. Epub 2018 Oct 1.

School of Psychology, University of Liverpool, Eleanor Rathbone Building, Bedford Street South, Liverpool, L69 7ZA, England.

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http://dx.doi.org/10.1007/s00415-018-9067-5DOI Listing
October 2018
1 Read