Search Our Scientific Publications & Authors

Sensors (Basel) 2019 Feb 13;19(4). Epub 2019 Feb 13.

School of Engineering, Macquarie University, Ryde, NSW 2113, Australia.

The Open-electroencephalography (EEG) framework is a popular platform to enable EEG measurements and general purposes Brain Computer Interface experimentations. However, the current platform is limited by the number of available channels and electrode compatibility. In this paper we present a fully configurable platform with up to 32 EEG channels and compatibility with virtually any kind of passive electrodes including textile, rubber and contactless electrodes. Read More

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira 187-8502, Japan.

Sleep disturbance is a common symptom in patients with various neurodegenerative diseases, including Alzheimer's disease (AD), and it can manifest in the early stages of the disease. Impaired sleep in patients with AD has been attributed to AD pathology that affects brain regions regulating the sleep⁻wake or circadian rhythm. However, recent epidemiological and experimental studies have demonstrated an association between impaired sleep and an increased risk of AD. Read More

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.

The pathogenesis of hypertension, as a multifactorial trait, is complex. High blood pressure levels, in turn, concur with the development of cardiovascular damage. Abnormalities of several neurohormonal mechanisms controlling blood pressure homeostasis and cardiovascular remodeling can contribute to these pathological conditions. Read More

Pathogens 2019 Feb 13;8(1). Epub 2019 Feb 13.

Department of Natural Sciences, School of Arts and Sciences, Lebanese American University, Byblos 36, Lebanon.

(SI) is associated with prolonged hospitalization and low survival rates. The genetic mechanisms involved in brain abscess development and genome evolution in comparison to other members of the group are understudied. We performed a whole-genome comparative analysis of an SI isolate, LAU_SINT, associated with brain abscess following sinusitis with all SI genomes in addition to and . Read More

Metabolites 2019 Feb 13;9(2). Epub 2019 Feb 13.

Institute of Pharmaceutical Science, Faculty of Life Sciences and Medicine, King's College London, London SE19NH, UK.

Introduction: Parkinson's disease (PD) is the second most common neurodegenerative disorder, without any widely available curative therapy. Metabolomics is a powerful tool which can be used to identify unexpected pathway-related disease progression and pathophysiological mechanisms. In this study, metabolomics in brain, plasma and liver was investigated in an experimental PD model, to discover small molecules that are associated with dopaminergic cell loss. Read More

Pharmaceutics 2019 Feb 18;11(2). Epub 2019 Feb 18.

Food and Drug Department, University of Parma, Parco Area delle Scienze 27/a, 43124 Parma, Italy.

Drug delivery to the brain represents a challenge, especially in the therapy of central nervous system malignancies. Simvastatin (SVT), as with other statins, has shown potential anticancer properties that are difficult to exploit in the central nervous system (CNS). In the present work the physico⁻chemical, mucoadhesive, and permeability-enhancing properties of simvastatin-loaded poly-ε-caprolactone nanocapsules coated with chitosan for nose-to-brain administration were investigated. Read More

Biomolecules 2019 Feb 18;9(2). Epub 2019 Feb 18.

Faculty of Mechanical Engineering, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 606-8585, Japan.

The control of ice growth in ice slurry is important for many fields, including (a) the cooling of the brain during cardiac arrest, (b) the storage and transportation of fresh fish and fruits, and (c) the development of distributed air-conditioning systems. One of the promising methods for the control is to use a substance such as antifreeze protein. We have observed and report here growth states of ice particles in both quiescent and flowing aqueous solutions of winter flounder antifreeze proteins in mini-channels with a microscope. Read More

Nanomaterials (Basel) 2019 Feb 18;9(2). Epub 2019 Feb 18.

Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), UMR 6303 CNRS/Université Bourgogne Franche-Comté, 21000 Dijon, France.

In this work, new nanohybrids based on superparamagnetic iron oxide nanoparticles (SPIONs) were elaborated and discussed for the first time as nanovectors of a derivative molecule of trans-resveratrol (RSV), a natural antioxidant molecule, which can be useful for brain disease treatment. The derivative molecule was chemically synthesized (4'-hydroxy-4-(3-aminopropoxy) trans-stilbene: HAPtS) and then grafted onto SPIONs surface using an organosilane coupling agent, which is 3-chloropropyltriethoxysilane (CPTES) and based on nucleophilic substitution reactions. The amount of HAPtS loaded onto SPIONs surface was estimated by thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS) analyses at 116 µmol·g SPIONs. Read More

Viruses 2019 Feb 18;11(2). Epub 2019 Feb 18.

Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

Venezuelan equine encephalitis virus (VEEV) is an alphavirus in the family Togaviridae. VEEV is highly infectious in aerosol form and a known bio-warfare agent that can cause severe encephalitis in humans. Periodic outbreaks of VEEV occur predominantly in Central and South America. Read More

Brain Sci 2019 Feb 18;9(2). Epub 2019 Feb 18.

Department of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

Despite substantial experience with deep brain stimulation for movement disorders and recent interest in electrode targeting under general anesthesia, little is known about whether awake macrostimulation during electrode targeting predicts postoperative side effects from stimulation. We hypothesized that intraoperative awake macrostimulation with the newly implanted DBS lead predicts dose-limiting side effects during device activation in clinic. We reviewed 384 electrode implants for movement disorders, characterized the presence or absence of stimulus amplitude thresholds for dose-limiting DBS side effects during surgery, and measured their predictive value for side effects during device activation in clinic with odds ratios ±95% confidence intervals. Read More

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Department of Clinic Neurophysiology, University Clinic Hospital of Valencia, Avda. Blasco Ibanez, 19, 46010 Valencia, Spain.

Vitamin E was proposed as treatment for Alzheimer's disease many years ago. However, the effectiveness of the drug is not clear. Vitamin E is an antioxidant and neuroprotector and it has anti-inflammatory and hypocholesterolemic properties, driving to its importance for brain health. Read More

Int J Environ Res Public Health 2019 Feb 18;16(4). Epub 2019 Feb 18.

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine, China Medical University, Taichung 404, Taiwan.

Use the National Health Insurance Research Database of Taiwan to determine whether patients with posttraumatic epilepsy (PTE) have an increased risk of mortality. Patients ≥20 years old ever admitted because of head injury (per International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 850⁻854 and 959.01) during 2000⁻2012 were enrolled into a traumatic brain injury (TBI) cohort. Read More

Antioxidants (Basel) 2019 Feb 18;8(2). Epub 2019 Feb 18.

Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Asturias 33006, Spain.

Differential antioxidant action is found upon comparison of organ/tissue systems in the human body. In erythrocytes (red blood cells), which transport oxygen and carbon dioxide through the circulatory system, the most important issue is to keep hemoglobin in a functional state that requires maintaining the haem group in ferrous (Fe) state. Conversion of oxidized Fe back into Fe in hemoglobin needs a special mechanism involving a tripeptide glutathione, glucose-6-phosphate dehydrogenase, and glucose and NADPH as suppliers of reducing power. Read More

Nutrients 2019 Feb 18;11(2). Epub 2019 Feb 18.

Department of human medicine, University of Zurich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.

In the last decade, the microbiome in general and the gut microbiome in particular have been associated not only to brain development and function, but also to the pathophysiology of brain aging and to neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), depression, or multiple sclerosis (MS) [... Read More

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Neuroepigenetics Laboratory-Navarrabiomed, Complejo Hospitalario de Navarra, Universidad Pública de Navarra (UPNA), IdiSNA (Navarra Institute for Health Research), Pamplona, Navarra 31008, Spain.

Lamins are fibrillary proteins that are crucial in maintaining nuclear shape and function. Recently, B-type lamin dysfunction has been linked to tauopathies. However, the role of A-type lamin in neurodegeneration is still obscure. Read More

Molecules 2019 Feb 18;24(4). Epub 2019 Feb 18.

National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China.

Amyloid-β, one of the hallmarks of Alzheimer's disease (AD), is toxic to neurons and can also cause brain cell death. Oxidative stress is known to play an important role in AD, and there is strong evidence that oxidative stress is associated with amyloid-β. In the present study we report the protective effect of Zijuan Pu'er tea water extract (ZTWE) and the mixture of main ingredients (+)-catechins, caffeine and procyanidin (MCCP) in ZTWE on β-amyloid-induced toxicity in transgenic () CL4176 expressing the human Aβ gene. Read More

Int J Mol Sci 2019 Feb 18;20(4). Epub 2019 Feb 18.

Department of Physiology, Medical University of Bialystok, Mickiewicza 2c Str., 15-222 Bialystok, Poland.

The latest studies have indicated a strong relationship between systemic insulin resistance (IR) and higher incidence of neurodegeneration, dementia, and mild cognitive impairment. Although some of these abnormalities could be explained by chronic hyperglycaemia, hyperinsulinemia, dyslipidaemia, and/or prolonged whole-body inflammation, the key role is attributed to the neuronal redox imbalance and oxidative damage. In this mini review, we provide a schematic overview of intracellular oxidative stress and mitochondrial abnormalities in the IR brain. Read More

Pharmaceutics 2019 Feb 17;11(2). Epub 2019 Feb 17.

Department of Chemistry and Pharmacy, University of Sassari, Sassari 07100, Italy.

The blood⁻brain barrier (BBB) plays a fundamental role in protecting the brain from toxic substances and therefore also controls and restricts the entry of therapeutic agents. The nasal administration of drugs using the nose-to-brain pathway allows direct drug targeting into the brain, avoiding the first-pass effect and bypassing the BBB. Through the nasal route, the drug can access the brain directly along the trigeminal and olfactory nerves, which are located in the upper part of the nasal cavity. Read More

Medicina (Kaunas) 2019 Feb 17;55(2). Epub 2019 Feb 17.

Department of Radiology, Nuclear Medicine and Medical Physics, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, M. K. Čiurlionio g. 21, 03101 Vilnius, Lithuania.

Magnetic resonance imaging (MRI) is used as a clarifying technique after a high-resolution ultrasound examination during pregnancy. Combining ultrasound with MRI, additional diagnostic information is obtained or ultrasound diagnosis is frequently corrected. High spatial resolution provides accurate radiological imaging of internal organs and widens possibilities for detecting perinatal development disorders. Read More

Cells 2019 Feb 17;8(2). Epub 2019 Feb 17.

Department of Biomedical Sciences, University of Padova, 35131 Padua, Italy.

Exosomes are a subgroup of extracellular vesicles containing a huge number of bioactive molecules. They represent an important means of cell communication, mostly between different cell populations, with the purpose of maintaining tissue homeostasis and coordinating the adaptive response to stress. This type of intercellular communication is important in the cardiovascular field, mainly due to the fact that the heart is a complex multicellular system. Read More

Nutrients 2019 Feb 17;11(2). Epub 2019 Feb 17.

Brain, Performance and Nutrition Research Centre, Northumbria University, Newcastle NE1 8ST, UK.

Mounting evidence points towards the existence of an association between energy intake in the evening and an increased prevalence and risk of being overweight and of obesity. The present study aimed to describe diurnal eating patterns (DEP) in a nationally representative sample of UK adolescents and to relate the derived DEP to anthropometrical measures. Data from four-day food records of adolescents aged 11⁻18 years participating in the 2008⁻2012 UK National Diet and Nutrition Survey Rolling Programme (NDNS RP) was utilised. Read More

Viruses 2019 Feb 16;11(2). Epub 2019 Feb 16.

Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA.

Zika virus (ZIKV) infections have caused a wide spectrum of neurological diseases, such as Guillain-Barré syndrome, myelitis, meningoencephalitis, and congenital microcephaly. No effective therapies currently exist for treating patients infected with ZIKV. MicroRNAs (miRNAs) are a group of small RNAs involved in the regulation of a wide variety of cellular and physiological processes. Read More

Cancers (Basel) 2019 Feb 16;11(2). Epub 2019 Feb 16.

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ 85259, USA.

Diagnosis-specific survival scores including a new score developed in 157 patients with brain metastases from small-cell lung cancer (SCLC) receiving whole-brain radiotherapy (WBRT) with 30 Gy in 10 fractions (WBRT-30-SCLC) were compared. Three prognostic groups were designed based on the 6-month survival probabilities of significant or almost significant factors, (age, performance score, number of brain metastases, extra-cerebral metastasis). Six-month survival rates were 6% (6⁻11 points), 44% (12⁻14 points) and 86% (16⁻19 points). Read More

Int J Mol Sci 2019 Feb 16;20(4). Epub 2019 Feb 16.

Department of Pharmacology, Department of Biomedicine and Health Sciences, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

(HE), a culinary-medicinal mushroom, has shown therapeutic potential in many brain diseases. However, the role of HE in status epilepticus (SE)-mediated neuronal death and its underlying mechanisms remain unclear. We investigated the neuroprotective effects of HE using a pilocarpine-induced SE model. Read More

Brain Sci 2019 Feb 15;9(2). Epub 2019 Feb 15.

Faculty of Life and Medical Sciences, Doshisha University, 1-3 Tatara Miyakodani, Kyotanabe, Kyoto 610-0394, Japan.

The ability to coordinate one's behavior with the others' behavior is essential to achieve a joint action in daily life. In this paper, the brain activity during synchronized tapping task was measured using functional near infrared spectroscopy (fNIRS) to investigate the relationship between time coordination and brain function. Furthermore, using brain functional network analysis based on graph theory, we examined important brain regions and network structures that serve as the hub when performing the synchronized tapping task. Read More

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Korea.

Neuronal death and reactive gliosis are major features of brain tissue damage following transient global cerebral ischemia (tgCI). This study investigated long-term changes in neuronal death and astrogliosis in the gerbil hippocampus for 180 days after 5 min of tgCI. A massive loss of pyramidal neurons was found in the hippocampal CA1 area (CA1) area between 5 and 30 days after tgCI by Fluoro-Jade B (FJB, a marker for neuronal degeneration) histofluorescence staining, but pyramidal neurons in the CA2/3 area did not die. Read More

Phys Rev E 2019 Jan;99(1-1):012321

Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

The structure of flow networks determines their function under normal conditions as well as their response to perturbative damage. Brain vasculature often experiences transient or permanent occlusions in the finest vessels, but it is not clear how these microclots affect the large-scale blood flow or to what extent they decrease functionality. Motivated by this, we investigate how flow is rerouted after the occlusion of a single edge in networks with a hierarchy in edge conductances. Read More

Phys Rev E 2019 Jan;99(1-1):012313

Centre for Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom.

Neural field models are commonly used to describe wave propagation and bump attractors at a tissue level in the brain. Although motivated by biology, these models are phenomenological in nature. They are built on the assumption that the neural tissue operates in a near synchronous regime, and hence, cannot account for changes in the underlying synchrony of patterns. Read More

Phys Rev E 2019 Jan;99(1-1):012319

Department of Communication and Information Technologies, Universitat Pompeu Fabra, 08018 Barcelona, Spain.

Inferring the topology of a network using the knowledge of the signals of each of the interacting units is key to understanding real-world systems. One way to address this problem is using data-driven methods like cross-correlation or mutual information. However, these measures lack the ability to distinguish the direction of coupling. Read More

Phys Rev E 2019 Jan;99(1-1):012421

School of Physics, University of Sydney, Sydney, New South Wales 2006, Australia and Center for Integrative Brain Function, University of Sydney, Sydney, New South Wales 2006, Australia.

Brain connectivity and structure-function relationships are analyzed from a physical perspective in place of common graph-theoretic and statistical approaches that overwhelmingly ignore the brain's physical structure and geometry. Field theory is used to define connectivity tensors in terms of bare and dressed propagators, and discretized representations are implemented that respect the physical nature and dimensionality of the quantities involved, retain the correct continuum limit, and enable diagrammatic analysis. Eigenfunction analysis is used to simultaneously characterize and probe patterns of brain connectivity and activity, in place of statistical or phenomenological patterns. Read More

Phys Rev E 2019 Jan;99(1-1):010302

Computational Physics for Engineering Materials, IfB, ETH Zürich, 8093 Zürich, Switzerland and Departamento de Fisica, Universidade Federal do Ceará, 60451-970 Fortaleza, Ceará, Brazil.

Pattern recognition is a fundamental neuronal process which enables a cortical system to interpret visual stimuli. How the brain learns to recognize patterns is, however, an unsolved problem. The frequently employed method of back propagation excels at this task but has been found to be unbiological in many aspects. Read More

Phys Rev E 2019 Jan;99(1-1):012316

Laboratory of Neural Computation, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, 38068 Rovereto, Italy.

Bifurcation theory is a powerful tool for studying how the dynamics of a neural network model depends on its underlying neurophysiological parameters. However, bifurcation theory of neural networks has been developed mostly for mean-field limits of infinite-size spin-glass models, for finite-size dynamical systems whose units have a graded, continuous output, and for models with discrete-output neurons that evolve in continuous time. To allow progress on understanding the dynamics of some widely used classes of neural network models with discrete units and finite size, which could not be studied thoroughly with the previous methodology, here we introduced algorithms that perform a semianalytical bifurcation analysis of a finite-size firing-rate neural network model with binary firing rates and discrete-time evolution. Read More

Phys Rev E 2019 Jan;99(1-1):012304

Department of Computer Science, University of California, Davis, California 95616, USA.

Synchronization phenomena are of broad interest across disciplines and increasingly of interest in a multiplex network setting. For the multiplex network of coupled Rössler oscillators, here we show how the master stability function, a celebrated framework for analyzing synchronization on a single network, can be extended to certain classes of multiplex networks with different intralayer and interlayer coupling functions. We derive three master stability equations that determine, respectively, the necessary regions of complete synchronization, intralayer synchronization, and interlayer synchronization. Read More

Phys Rev E 2019 Jan;99(1-1):012113

Research Institute for Technical Physics and Materials Science, Centre for Energy Research of the Hungarian Academy of Sciences, P.O. Box 49, H-1525 Budapest, Hungary.

I provide numerical evidence for the robustness of the Griffiths phase (GP) reported previously in dynamical threshold model simulations on a large human brain network with N=836733 connected nodes. The model, with equalized network sensitivity, is extended in two ways: introduction of refractory states or by randomized time-dependent thresholds. The nonuniversal power-law dynamics in an extended control parameter region survives these modifications for a short refractory state and weak disorder. Read More

Psychogeriatrics 2019 Feb 19. Epub 2019 Feb 19.

School of Humanities and Social Sciences, Harbin Medical University, Harbin, China.

Background: To evaluate the effect of vortioxetine combined with cognitive behaviour intervention on the level of brain-derived neurotrophic factor (BDNF) in the serum of patients with depression and its therapeutic effect.

Methods: A total of 82 depressive patients treated at the School of Basic Medicine, Heilongjiang University of Chinese Medicine from January 2017 to June 2017 were randomised into a control group (n = 41) and intervention group (n = 41) according to a random number table. Both groups were given vortioxetine treatment, while the intervention group adopted an additional cognitive-behavioural therapy at the same time. Read More

Drug Res (Stuttg) 2019 Feb 19. Epub 2019 Feb 19.

Centre for Biocomputing and Drug Development, Adekunle Ajasin University, Akungba Akoko, Ondo State Nigeria.

Background: BACE-1 is an aspartate protease that is responsible for the proteolysis of amyloid precursor proteins (APP) into beta-amyloid (Aβ), a neurotoxic peptide in patients with Alzheimer's disease (AD). As such, BACE-1 is a prime pharmacological target in the control of Aβ in the brain and its inhibition will be a sound approach in AD therapy.

Methods: The computational pipeline which comprised molecular docking (MD), Quantitative Structure Activity Relationship (QSAR) modelling and Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) studies enabled the prediction of molecular interaction and relative inhibitory potentials of the hit compound. Read More

Neuropsychopharmacology 2019 Feb 19. Epub 2019 Feb 19.

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Frequent cannabis use during adolescence has been associated with alterations in brain structure. However, studies have featured relatively inconsistent results, predominantly from small samples, and few studies have examined less frequent users to shed light on potential brain structure differences across levels of cannabis use. In this study, high-resolution T1-weighted MRIs were obtained from 781 youth aged 14-22 years who were studied as part of the Philadelphia Neurodevelopmental Cohort. Read More

Phys Med Biol 2019 Feb 19. Epub 2019 Feb 19.

School of Information Technology and Electrical Engineering, University of Queensland, Brisbane, Queensland, AUSTRALIA.

Insertable head gradient coils offer significant advantages such as high gradient strength and fast gradient switching speed owing to close distance to the target region of interest than whole-body cylindrical coils. To produce superior gradient performance, the local head coil is typically designed with an asymmetric configuration to accommodate both the shoulders and head of a patient, leading to tough dimensional constraints and practical limits to the coil implementation. In this paper, we proposed a new cone-shaped model to improve the performance of the asymmetric head coils and also to mitigate patient claustrophobia. Read More

Comp Biochem Physiol Part D Genomics Proteomics 2019 Feb 13;30:55-70. Epub 2019 Feb 13.

Programme for Physiology and Neurobiology, Department of Molecular Biosciences, University of Oslo, Norway.

We investigated if transcriptional responses are consistent with the arrest of synaptic activity in the anoxic turtle (Trachemys scripta) brain. Thirty-nine genes of key receptors, transporters, enzymes and regulatory proteins of inhibitory and excitatory neurotransmission were partially cloned and their expression in telencephalon of 21 °C- and 5 °C-acclimated normoxic, anoxic (24 h at 21 °C; 1 and 14 days at 5 °C) and reoxygenated (24 h at 21 °C; 13 days at 5 °C) turtles quantified by real-time RT-PCR. Gene expression was largely sustained with anoxia at 21 °C and 5 °C. Read More

Cognition 2019 Feb 15;186:139-146. Epub 2019 Feb 15.

Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, the Netherlands.

Unexpected events provide us with opportunities for learning about what to expect from the world around us. Using a saccadic-planning paradigm, we investigated whether and how infants and adults represent the statistics of a changing environment (i.e. Read More

Neural Netw 2019 Feb 1;113:41-53. Epub 2019 Feb 1.

Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, RI 02881, USA. Electronic address:

This paper presents a deep associative neural network (DANN) based on unsupervised representation learning for associative memory. In brain, the knowledge is learnt by associating different types of sensory data, such as image and voice. The associative memory models which imitate such a learning process have been studied for decades but with simpler architectures they fail to deal with large scale complex data as compared with deep neural networks. Read More

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

International Neuroscience Institute, Department of Neurosurgery Rudolf-Pichlmayr-Straße 4 D - 30625 Hannover Germany; Leibniz Institute, Germany.

Background: Intraoperative assessment of the functional connectivity (FC) provides a new possibility of mapping the eloquent brain region before, during, and after tumor resection. a systematic analysis of the detectability of FC and its variation between subjects and session.

Methods: the FC was analyzed in 10 pituitary adenoma patients under propofol anesthesia before and after tumor resection. Read More

World Neurosurg 2019 Feb 16. Epub 2019 Feb 16.

Department of Neurosurgery, Albany Medical Center, Albany, NY, USA.

Polycythemia vera (PV) is a myeloproliferative disorder usually characterized by an increase tendency towards thromboembolic events. Spontaneous hemorrhage/bleeding in PV patients is seldom reported in Neurosurgical literature. We report the case of a 76 year-old male with PV who developed a spontaneous subdural hematoma requiring surgical evacuation. Read More

J Thorac Oncol 2019 Feb 16. Epub 2019 Feb 16.

Department of medical oncology, Gustave Roussy Cancer Campus, Institut d'Oncologie Thoracique (IOT), Gustave Roussy, Université Paris-Saclay, F-94805, Villejuif, France; Paris-Sud University, Orsay, France.

Introduction: although frequent in non-small cell lung cancer (NSCLC), brain metastases (BM) patients are often excluded from immune checkpoint inhibitor (ICI) trials. We evaluated BM outcome in a less selected NSCLC cohort.

Methods: data from consecutive advanced ICI treated NSCLC patients were collected. Read More

Behav Brain Res 2019 Feb 16. Epub 2019 Feb 16.

Department of Anesthesiology, Renmin hospital of Wuhan University, Wuhan, 430060, Hubei Province, China. Electronic address:

Sleep disturbance can result in memory impairment, and both sleep and hippocampal memory formation are maintained by circadian clock genes. Although preoperative sleep deprivation is known to be an independent risk factor for postoperative cognitive dysfunction (POCD) after inhalation anesthesia, the circadian mechanisms involved are currently unclear. To examine this issue, we constructed models of rapid eye movement sleep deprivation (RSD) and POCD after sevoflurane inhalation, to evaluate the circadian mechanisms underlying preoperative sleep deprivation-induced POCD after sevoflurane inhalation. Read More

Behav Brain Res 2019 Feb 16. Epub 2019 Feb 16.

Behavioral Pharmacology Group, Laboratory of Animal Morphology and Pathology, State University of North Fluminense Darcy Ribeiro, Avenida Alberto Lamego, 2000, Campos dos Goytacazes, 28013-602, RJ, Brazil. Electronic address:

Increases in medial prefrontal cortex ERK have been linked to learning and memory processes. In the present study separate groups of rats initially underwent testing in an open-field paired with either 2.0 mg/kg apomorphine or vehicle injections. Read More

Behav Brain Res 2019 Feb 16. Epub 2019 Feb 16.

Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan. Electronic address:

We previously demonstrated that glucagon-like peptide-2 (GLP-2) exerted antidepressant-like effects in mice. The aim of the present study was to investigate the relationship between N-methyl--aspartate (NMDA) receptor-nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway and the antidepressant-like effects of GLP-2 in the forced-swim test (FST) in mice. Intracerebroventricularly administered GLP-2 (3 μg/mouse) decreased the immobility time in the FST. Read More

Neurosci Lett 2019 Feb 16. Epub 2019 Feb 16.

Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, 60611 IL, USA; Northwestern University Center for Autism and Neurodevelopment, Chicago IL 60611, USA. Electronic address:

GABAergic interneurons are emerging as prominent substrates in the pathophysiology of multiple neurodevelopmental disorders, including autism spectrum disorders, schizophrenia, intellectual disability, and epilepsy. Interneuron excitatory activity is influenced by 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propanoic acid receptors (AMPARs), which in turn affects excitatory transmission in the central nervous system. Yet how dysregulation of interneuronal AMPARs distinctly contributes to the molecular underpinning of neurobiological disease is drastically underexplored. Read More

Neurosci Biobehav Rev 2019 Feb 16. Epub 2019 Feb 16.

Brain and Behaviour Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK; The International Zebrafish Neuroscience Research Consortium (ZNRC), 309 Palmer Court, Slidell, LA 70458, USA. Electronic address:

Attention deficit hyperactivity disorder (ADHD) is a common, debilitating neurodevelopmental disorder associated with inattentiveness, pathological hyperactivity and impulsivity. Despite the mounting human and animal evidence, the neurological pathways underlying ADHD remain poorly understood. Novel translational model organisms, such as the zebrafish (Danio rerio), are becoming important tools to investigate genetic and pathophysiological mechanisms of various neuropsychiatric disorders. Read More