430 results match your criteria Brain Imaging in Hemangioblastoma


Hypervascular Lesions of the Cerebellopontine Angle: The Relevance of Angiography as a Diagnostic and Therapeutic Tool and the Role of Stereotactic Radiosurgery in Management. A Comprehensive Review.

World Neurosurg 2017 Apr 31;100:100-117. Epub 2016 Dec 31.

Division of Neurosurgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

Background: The cerebellopontine angle (CPA) is a narrowed skull base area containing important cranial nerves and vessels and bordering with eloquent areas of the posterior fossa. Tumors of the CPA are a heterogeneous group and can have extradural, intradural/extra-axial, or intra-axial origins. Their vascular supply changes depending on their anatomic origin. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.12.091DOI Listing
April 2017
3 Reads

Ruptured Massa Intermedia Secondary to Hydrocephalus.

World Neurosurg 2017 Jan 4;97:749.e7-749.e10. Epub 2016 Nov 4.

Department of Neurosurgery, University Medicine Greifswald, Greifswald, Germany.

Background: We report a case of ruptured massa intermedia (MI) as a sequela of hydrocephalus.

Case Description: A single case report is presented describing the sequelae of tumor bed hematoma after a posterior fossa hemangioblastoma resection in which the patient bled 3 days after surgery, resulting in secondary hydrocephalus and subsequently dilatation of the third ventricle, which resulted in rupture of the MI. The patient was managed on emergency basis with an external ventricular drain then endoscopically with a third ventriculostomy and clot extraction. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.10.131DOI Listing
January 2017
7 Reads
2.420 Impact Factor

Bulbar dysfunction and aspiration pneumonia due to a brainstem haemangioblastoma: an unusual complication of von Hippel-Lindau disease.

BMJ Case Rep 2016 Oct 13;2016. Epub 2016 Oct 13.

Department of Medical Genetics, University of Cambridge School of Clinical Medicine, Cambridge, UK.

A 44-year-old woman with a history of von Hippel-Lindau (VHL) disease, a rare inherited neoplasia syndrome, presented acutely to hospital with a productive cough, symptoms of respiratory tract infection and odynophagia (painful swallowing). A chest X-ray confirmed right-sided pneumonia. Investigation of the persistent odynophagia using barium swallow revealed aspiration of the contrast into the lungs and suggested a neurological cause for her chest infection. Read More

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http://dx.doi.org/10.1136/bcr-2016-217076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073630PMC
October 2016
10 Reads

Unusual case of recurrent SMART (stroke-like migraine attacks after radiation therapy) syndrome.

Ann Indian Acad Neurol 2016 Jul-Sep;19(3):399-401

Associate Professor of Neurology, Allegheny Health Network, Pittsburgh, Pennsylvania, United States.

Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare delayed complication of cerebral radiation therapy. A 53-year-old female initially presented with headache, confusion and left homonymous hemianopia. Her medical history was notable for cerebellar hemangioblastoma, which was treated with radiation in 1987. Read More

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http://dx.doi.org/10.4103/0972-2327.168634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4980969PMC
August 2016
83 Reads
3 Citations
0.514 Impact Factor

Usefulness of high-resolution 3D multifusion medical imaging for preoperative planning in patients with posterior fossa hemangioblastoma: technical note.

J Neurosurg 2017 Jul 26;127(1):139-147. Epub 2016 Aug 26.

Departments of 1 Neurosurgery and.

Successful resection of hemangioblastoma depends on preoperative assessment of the precise locations of feeding arteries and draining veins. Simultaneous 3D visualization of feeding arteries, draining veins, and surrounding structures is needed. The present study evaluated the usefulness of high-resolution 3D multifusion medical imaging (hr-3DMMI) for preoperative planning of hemangioblastoma. Read More

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http://dx.doi.org/10.3171/2016.5.JNS152646DOI Listing
July 2017
30 Reads

Intraoperative fluorescein staining for benign brain tumors.

Clin Neurol Neurosurg 2016 Oct 11;149:22-6. Epub 2016 Jul 11.

Department of Neurosurgery, University Hospital "Saint Ivan Rilski", Sofia, Bulgaria.

Objective: Successful use of high-dose fluorescein-sodium (20mg/kg) with a standard light microscope for resection of high-grade gliomas, meningiomas, hemangioblastoma and metastases was reported. The principle of brain tumor staining by fluorescein-sodium (Fl-Na) consists in the accumulation of fluorescein in brain tumors with impaired blood-brain barrier. The aim of our study was to investigate for the first time the usefulness of high-dose fluorescein in patients operated on for benign neuroepithelial brain tumors (grade I WHO tumors) with contrast enhancement on magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.clineuro.2016.07.016DOI Listing
October 2016
18 Reads

Genotype-phenotype analysis of von Hippel-Lindau syndrome in Korean families: HIF-α binding site missense mutations elevate age-specific risk for CNS hemangioblastoma.

BMC Med Genet 2016 07 20;17(1):48. Epub 2016 Jul 20.

Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

Background: von Hippel-Lindau (VHL) disease is a rare hereditary tumor syndrome caused by VHL gene mutations that is characterized by heterogeneous phenotypes such as benign/malignant tumors of the central nervous system, retina, kidney, adrenal gland, and pancreas. The genotype-phenotype correlation has not been well characterized in the Korean population so far. Therefore, this study aimed to evaluate the VHL mutation spectrum and genotype-phenotype correlations in Korean VHL patients. Read More

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http://dx.doi.org/10.1186/s12881-016-0306-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4955248PMC
July 2016
60 Reads

Neuroimaging of spine tumors.

Handb Clin Neurol 2016 ;136:689-706

Dent Neurologic Institute, Amherst, NY, USA. Electronic address:

Intramedullary, intradural/extramedullary, and extradural spine tumors comprise a wide range of neoplasms with an even wider range of clinical symptoms and prognostic features. Magnetic resonance imaging (MRI), commonly used to evaluate the spine in patients presenting with pain, can further characterize lesions that may be encountered on other imaging studies, such as bone scintigraphy or computed tomography (CT). The advantage of the MRI is its multiplane capabilities, superior contrast agent resolution, and flexible protocols that play an important role in assessing tumor location, extent in directing biopsy, in planning proper therapy, and in evaluating therapeutic results. Read More

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http://dx.doi.org/10.1016/B978-0-444-53486-6.00033-8DOI Listing
February 2017
23 Reads

The significance of incidental brain uptake on 68Ga-DOTATATE PET-CT in neuroendocrine tumour patients.

Nucl Med Commun 2016 Nov;37(11):1197-205

Departments of aNuclear Medicine bRadiology, Royal Free London NHS Foundation Trust, London, UK cMelbourne Brain Centre Imaging Unit, Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Australia.

Objective: Radiolabelled somatostatin analogues detect neuroendocrine tumours (NETs), but may reveal other tumour types. We examined the prevalence of possible meningioma in patients with known or suspected NETs imaged with Ga-DOTATATE PET-computed tomography (CT) on the basis of central nervous system uptake and compared with findings on magnetic resonance and contrast-enhanced CT imaging.

Methods: Retrospective imaging reports from 313 patients who had undergone Ga-DOTATATE PET imaging for primary or repeat NET staging were searched to identify suspected meningiomas on PET. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000571DOI Listing
November 2016
21 Reads

Metastatic cerebellar tumor of papillary thyroid carcinoma mimicking cerebellar hemangioblastoma.

Springerplus 2016 29;5(1):916. Epub 2016 Jun 29.

Department of Pathology, Yamaguchi University Graduate School of Medicine, Ube, Japan.

Introduction: Well-differentiated papillary thyroid carcinoma generally (PTC) have a favorable prognosis. This metastasis is rare in the central nervous system. Brain metastasis has a relatively poor prognosis. Read More

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http://dx.doi.org/10.1186/s40064-016-2551-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927557PMC
July 2016
8 Reads

Hemangioblastoma located in the posterior incisural space mimicking a tentorial meningioma: a case report.

J Med Case Rep 2016 Jun 23;10(1):183. Epub 2016 Jun 23.

Institute of Medical Research A Lanari, University of Buenos Aires, Combatiente de Malvinas 3150. 1427, Buenos Aires, Argentina.

Background: The most common type of vascularized tumor located in the posterior incisural space in older patients is the falcotentorial meningioma. Solid hemangioblastomas are rarely found in this particular area of the brain. To the best of our knowledge, the case of only one patient harboring a hemangioblastoma not associated with Von Hippel-Lindau disease has been previously reported in the literature in this anatomic region. Read More

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http://dx.doi.org/10.1186/s13256-016-0962-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918118PMC
June 2016
26 Reads

Differentiating Hemangioblastomas from Brain Metastases Using Diffusion-Weighted Imaging and Dynamic Susceptibility Contrast-Enhanced Perfusion-Weighted MR Imaging.

AJNR Am J Neuroradiol 2016 Oct 12;37(10):1844-1850. Epub 2016 May 12.

From the Department of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, P.R. China.

Background And Purpose: On DWI and DSC-PWI, hemangioblastomas and brain metastases may exhibit different signal intensities depending on their cellularity and angiogenesis. The purpose of this study was to evaluate whether a hemangioblastoma can be differentiated from a single brain metastasis with DWI and DSC-PWI.

Materials And Methods: We retrospectively reviewed DWI, DSC-PWI, and conventional MR imaging of 21 patients with hemangioblastomas and 30 patients with a single brain metastasis. Read More

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http://dx.doi.org/10.3174/ajnr.A4809DOI Listing
October 2016
6 Reads

Suprasellar Hemangioblastoma Unrelated to von Hippel-Lindau Disease Successfully Treated through Extended Transsphenoidal Approach: Diagnostic Value of Von Hippel-Lindau Disease Gene-Derived Protein.

J Neurol Surg A Cent Eur Neurosurg 2017 May 28;78(3):296-301. Epub 2016 Apr 28.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.

Hemangioblastoma tends to occur in the infratentorial regions and rarely in the supratentorial regions. This tumor is strongly associated with von Hippel-Lindau disease (VHLD), especially in the supratentorial regions, with only 12 cases of suprasellar hemangioblastoma unrelated to VHLD. However, all these cases were diagnosed based on clinical screening and confirmation of family history. Read More

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http://dx.doi.org/10.1055/s-0036-1582016DOI Listing
May 2017
26 Reads

Differentiation of Hemangioblastoma from Metastatic Brain Tumor using Dynamic Contrast-enhanced MR Imaging.

Clin Neuroradiol 2017 Sep 7;27(3):329-334. Epub 2016 Mar 7.

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81, Irwon-ro, Gangnam-gu, 135-710, Seoul, Republic of Korea.

Purpose: The aim of this study was to differentiate hemangioblastomas from metastatic brain tumors using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and compare the diagnostic performances with diffusion-weighted imaging (DWI) and dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI).

Methods: We retrospectively reviewed 7 patients with hemangioblastoma and 15 patients with metastatic adenocarcinoma with magnetic resonance imaging (MRI) including DWI, DSC-MRI, and DCE-MRI. Apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), and DCE-MRI parameters (K , k , v , and v ) were compared between the two groups. Read More

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http://dx.doi.org/10.1007/s00062-016-0508-1DOI Listing
September 2017
2 Reads

The Trans-Visible Navigator: A See-Through Neuronavigation System Using Augmented Reality.

World Neurosurg 2016 Mar 28;87:399-405. Epub 2015 Dec 28.

Department of Neurosurgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.

Introduction: The neuronavigator has become indispensable for brain surgery and works in the manner of point-to-point navigation. Because the positional information is indicated on a personal computer (PC) monitor, surgeons are required to rotate the dimension of the magnetic resonance imaging/computed tomography scans to match the surgical field. In addition, they must frequently alternate their gaze between the surgical field and the PC monitor. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750150170
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http://dx.doi.org/10.1016/j.wneu.2015.11.084DOI Listing
March 2016
10 Reads

Infundibular Hemangioblastoma in a Patient with Neurofibromatosis Type 1: Case Report and Review of the Literature.

World Neurosurg 2016 Apr 25;88:693.e7-693.e12. Epub 2015 Dec 25.

Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; University of Cincinnati Neuroscience Institute, Cincinnati, Ohio, USA; Mayfield Clinic, Cincinnati, Ohio, USA. Electronic address:

Background: Supratentorial hemangioblastomas are rare tumors, most commonly occurring in the sellar/suprasellar region, cerebrum, and ventricle. They are generally found in patients with von Hippel Lindau disease but have infrequently been reported in patients without this syndrome.

Case Description: A 35-year-old woman with a history of neurofibromatosis type 1 presented to our care with visual loss and headaches. Read More

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http://dx.doi.org/10.1016/j.wneu.2015.12.030DOI Listing
April 2016
7 Reads

Neuro-Ophthalmic and Clinical Characteristics of Brain Tumours in a Tertiary Hospital in Ghana.

Ghana Med J 2015 Sep;49(3):181-6

University of Ghana Dental School, College of Health Sciences, Korle-Bu Teaching Hospital, Accra, Ghana.

Background: Anecdotally, increasing number of patients are seen at Korle Bu Teaching Hospital (KBTH) with brain tumour. Neuro-ophthalmic symptoms and signs may help in timely diagnosis and intervention.

Objective: To evaluate the neuro-ophthalmic and clinical characteristics of brain tumour in patients presenting at a tertiary hospital in Ghana. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676598PMC
http://dx.doi.org/10.4314/gmj.v49i3.9DOI Listing
September 2015
9 Reads

Tuberculous meningitis with dementia as the presenting symptom after intramedullary spinal cord tumor resection.

Nagoya J Med Sci 2015 Nov;77(4):653-7

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Early-stage TB meningitis has no specific symptoms in patients, potentially leading to delayed diagnosis and consequently worsening prognosis. The authors present the fatal case with a delayed diagnosis of tuberculous (TB) meningitis with dementia as the presenting symptom after intramedullary spinal cord tumor resection. The medical records, operative reports, and radiographical imaging studies of a single patient were retrospectively reviewed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664597PMC
November 2015
39 Reads

Biological and clinical impact of hemangioblastoma-associated peritumoral cysts in von Hippel-Lindau disease.

J Neurosurg 2016 Apr 30;124(4):971-6. Epub 2015 Oct 30.

Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio;

Objective: Peritumoral cysts are frequently associated with CNS hemangioblastomas and often underlie neurological morbidity and mortality. To determine their natural history and clinical impact, the authors prospectively analyzed hemangioblastoma-associated peritumoral cysts in patients with von Hippel-Lindau (VHL) disease.

Methods: Patients with VHL disease who had 2 or more years of follow-up and who were enrolled in a prospective study at the National Institutes of Health were included. Read More

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http://dx.doi.org/10.3171/2015.4.JNS1533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818154PMC
April 2016
19 Reads

Recurrent multiple CNS hemangioblastomas with VHL disease treated with pazopanib: a case report and literature review.

CNS Oncol 2015 26;4(6):387-92. Epub 2015 Oct 26.

Centre of Oncology, University Hospital of Geneva, Geneva, Switzerland.

Hemangioblastoma is a rare benign neoplasm, accounting for less than 2% of all primitive brain tumors. It may arise sporadically in a solitary form, or associated with Von Hippel-Lindau (VHL) disease with multiple tumors. Surgery is the mainstay treatment, but management is challenging in case of recurrent and/or multiple tumors. Read More

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http://dx.doi.org/10.2217/cns.15.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083944PMC
August 2016
61 Reads
1 Citation

A case of 3p deletion syndrome associated with cerebellar hemangioblastoma.

Brain Dev 2016 02 11;38(2):257-60. Epub 2015 Sep 11.

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.

We described clinical course of a 24-year-old woman with 3p deletion syndrome associated with cerebellar hemangioblastoma at the age of 16 years old. She presented dysmorphic facial features, growth retardation and severe psychomotor retardation associated with 3p deletion syndrome. We identified de novo 3p deletion encompassing p25 by using array-based comparative genomic hybridization, where causative gene of von Hippel-Lindau (VHL) disease located. Read More

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http://dx.doi.org/10.1016/j.braindev.2015.07.005DOI Listing
February 2016
31 Reads

Clinical presentation and mutation analysis of VHL disease in a large Chinese family.

J Neurooncol 2015 Nov 4;125(2):369-75. Epub 2015 Sep 4.

Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China.

Von Hippel-Lindau (VHL) disease is an autosomal dominantly inherited neoplastic disorder characterized by marked phenotypic variability and age-dependent penetrance. This disease is caused by germline mutations in the VHL tumor suppressor gene. Systematic physical examinations, imaging assessments and molecular genetic tests for the VHL gene were performed in a large Chinese VHL family. Read More

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http://link.springer.com/content/pdf/10.1007/s11060-015-1924
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http://link.springer.com/10.1007/s11060-015-1924-9
Publisher Site
http://dx.doi.org/10.1007/s11060-015-1924-9DOI Listing
November 2015
28 Reads

Time-Resolved Magnetic Resonance Angiography in the Evaluation of Intracranial Vascular Lesions and Tumors: A Pictorial Essay of Our Experience.

Can Assoc Radiol J 2015 Nov 12;66(4):385-92. Epub 2015 Aug 12.

Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Radiological Technology, Central Taiwan University of Science and Technology, Taichung, Taiwan.

Time-resolved magnetic resonance angiography (TR MRA) is a promising less invasive technique for the diagnosis of intracranial vascular lesions and hypervascular tumors. Similar to 4-dimensional computed tomographic angiography obtaining high frame rate images, TR MRA utilizes acceleration techniques to acquire sequential arterial and venous phase images for identifying, localizing, and classifying vascular lesions. Because of the good agreement with digital subtraction angiography for grading brain arteriovenous malformations with the Spetzler-Martin classification and the good sensitivity for visualizing arteriovenous fistulas, studies have suggested that TR MRA could serve as a screening or routine follow-up tool for diagnosing intracranial vascular disorders. Read More

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http://dx.doi.org/10.1016/j.carj.2015.05.001DOI Listing
November 2015
3 Reads

Suprasellar hemangioblastoma without von Hippel-Lindau disease: a case report and literature review.

Int J Clin Exp Pathol 2015 1;8(6):7553-8. Epub 2015 Jun 1.

Department of Neurosurgery, Shengjing Hospital, China Medical University Shenyang 110004, Liaoning, China.

Suprasellar hemangioblastoma (HBL) without von Hippel-Lindau (VHL) disease is extremely rare. A 51-year-old woman presented with headache and progressively deteriorating bilateral visual disturbance for 4 months. Magnetic resonance imaging (MRI) revealed a 2. Read More

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http://www.ijcep.com/files/ijcep0008755.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526002PMC
May 2016
2 Reads

Genetic imprinting suggested by maternal DNA methylation in CNS hemangioblastoma with clinical phenotypes of VHL disease.

J Neurooncol 2015 Sep 21;124(3):525-7. Epub 2015 Jun 21.

Department of Neurosurgery, Huashan Hospital, Fudan University, Wulumuqi Road 12#, Shanghai, 200040, China.

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http://dx.doi.org/10.1007/s11060-015-1852-8DOI Listing
September 2015
7 Reads

Neurosurgical Management of Brainstem Hemangioblastomas: A Single-Institution Experience with 116 Patients.

World Neurosurg 2015 Oct 28;84(4):1030-8. Epub 2015 May 28.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Objective: Brainstem hemangioblastomas (HBs) are considered one of the most challenging lesions in surgical procedures. We present our institutional experience with 116 patients over a period of 20 years in the treatment of HBs.

Methods: We evaluated the results of microsurgical treatment and highlighted the management strategies. Read More

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http://dx.doi.org/10.1016/j.wneu.2015.05.030DOI Listing
October 2015
7 Reads

Medullary hemangioblastoma in a child with von Hippel-Lindau disease: vascular tumor perfusion depicted by arterial spin labeling and dynamic contrast-enhanced imaging.

J Neurosurg Pediatr 2015 Jul 17;16(1):50-3. Epub 2015 Apr 17.

Department of Neurosurgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Medullary hemangioblastoma is very rare in children. Based on small nodular enhancement with peritumoral edema and without dilated feeding arteries on conventional MRI, hemangioblastoma, pilocytic astrocytoma, oligodendroglioma, and ganglioglioma were included in the differential diagnosis of the medullary tumor. In this case report, the authors emphasize the diagnostic value of arterial spin labeling and dynamic contrast-enhanced MRI in demonstrating vascular tumor perfusion of hemangioblastoma in a 12-year-old boy who was later found to have von Hippel-Lindau disease. Read More

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http://dx.doi.org/10.3171/2014.12.PEDS14609DOI Listing
July 2015
17 Reads

Stereotactic radiosurgery for intracranial hemangioblastomas: a retrospective international outcome study.

J Neurosurg 2015 Jun 27;122(6):1469-78. Epub 2015 Mar 27.

Departments of 1Neurological Surgery, University of Pittsburgh, Pennsylvania;

Object: The purpose of this study was to evaluate the role of stereotactic radiosurgery (SRS) in the management of intracranial hemangioblastomas.

Methods: Six participating centers of the North American Gamma Knife Consortium and 13 Japanese Gamma Knife centers identified 186 patients with 517 hemangioblastomas who underwent SRS. Eighty patients had 335 hemangioblastomas associated with von Hippel-Lindau disease (VHL) and 106 patients had 182 sporadic hemangioblastomas. Read More

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http://dx.doi.org/10.3171/2014.10.JNS131602DOI Listing
June 2015
47 Reads

[A case of cerebellar hemangioblastoma complicated by pregnancy and concerns about the surgical period].

No Shinkei Geka 2015 Jan;43(1):57-62

Department of Neurosurgery, Ehime University School of Medicine.

We report herein a case of cerebellar hemangioblastoma complicated by pregnancy and concerns about the period in which surgery could be performed successfully. A 19-year-old woman, who was also 35 weeks pregnant, was admitted to our hospital with headache, nausea, and general fatigue. Neurological examination on admission revealed disturbed consciousness, and the patient's general condition was poor. Read More

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https://webview.isho.jp/journal/detail/abs/10.11477/mf.14362
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http://dx.doi.org/10.11477/mf.1436202946DOI Listing
January 2015
4 Reads

A spinal tumor showing mixed features of ependymoma and hemangioblastoma: a case report and literature review.

Brain Tumor Pathol 2015 Apr 17;32(2):112-8. Epub 2014 Dec 17.

Department of Neuropathology, Huashan Hospital of Fudan University, 12 Wu Lu Mu Qi Zhong Road, Shanghai, 200040, China.

We report an intramedullary spinal tumor consisting of an ependymoma and a hemangioblastoma (HB). A 37-year-old woman presented with progressive bilateral lower limb sensory and motor deficits. Magnetic resonance imaging showed a single intramedullary mass in the thoracic cord (T4-T6 level). Read More

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http://dx.doi.org/10.1007/s10014-014-0208-yDOI Listing
April 2015
22 Reads

Differentiation of hemangioblastomas from pilocytic astrocytomas using 3-T magnetic resonance perfusion-weighted imaging and MR spectroscopy.

Neuroradiology 2015 Mar 7;57(3):275-81. Epub 2014 Dec 7.

Department of Radiology, First Affiliated Hospital of Fujian Medical University, 20 Cha-Zhong Road, Fuzhou, Fujian, 350005, People's Republic of China.

Introduction: Hemangioblastomas and pilocytic astrocytomas (PAs) present similar imaging features on conventional MR imaging, making differential diagnosis a challenge. The purpose of this study was to evaluate the usefulness of dynamic susceptibility-weighted contrast-enhanced perfusion-weighted imaging (DSC-PWI) and proton MR spectroscopic imaging in the differentiation of hemangioblastomas and PAs.

Methods: A 3. Read More

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http://dx.doi.org/10.1007/s00234-014-1475-3DOI Listing
March 2015
39 Reads

Clinical and pathological analysis of benign brain tumors resected after Gamma Knife surgery.

J Neurosurg 2014 Dec;121 Suppl:179-87

Gamma Knife Center and.

Object: The goal of this study was to assess the clinical and pathological features of benign brain tumors that had been treated with Gamma Knife surgery (GKS) followed by resection.

Methods: In this retrospective chart review, the authors identified 61 patients with intracranial benign tumors who had undergone neurosurgical intervention after GKS. Of these 61 patients, 27 were male and 34 were female; mean age was 49. Read More

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http://dx.doi.org/10.3171/2014.8.GKS141439DOI Listing
December 2014
8 Reads

Pearls & Oy-sters: Anorexia and emaciation in patients with cerebellar hemangioblastoma.

Neurology 2014 Sep;83(14):1298-300

From the Department of Neurosurgery, Saitama Medical Center, Saitama Medical University, Japan.

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http://dx.doi.org/10.1212/WNL.0000000000000835DOI Listing
September 2014
6 Reads

Lateral ventricle haemangioblastoma: the role of perfusion scanning and embolisation in diagnosis and management.

BMJ Case Rep 2014 Sep 25;2014. Epub 2014 Sep 25.

Department of Neurosurgery, Leeds General Infirmary, Leeds, West Yorkshire, UK.

We present the case of a 24-year-old man who presented with vertigo and right-sided weakness. Subsequent imaging demonstrated a lateral ventricle haemangioblastoma. This is the first case ever to be treated with surgical excision augmented by preoperative endovascular embolisation, as illustrated with perfusion CT scanning performed pre-embolisation and postembolisation. Read More

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http://dx.doi.org/10.1136/bcr-2014-205736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180557PMC
September 2014
25 Reads

Bilateral Optic Nerve Head Angiomas and Retrobulbar Haemangioblastomas in von Hippel-Lindau Disease.

Neuroophthalmology 2014 19;38(5):254-256. Epub 2014 Sep 19.

Farabi Eye Research Center, Department of Ophthalmology, Tehran University of Medical Sciences Tehran Iran.

A 39-year-old man presented with progressive visual loss in both eyes. His past medical history was remarkable for biopsy-proven bilateral adrenal phaeochromocytomas. Ophthalmoscopy revealed an optic nerve head angioma and macular lipid exudates in the right eye and a regressed optic nerve head angioma in the left eye. Read More

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http://dx.doi.org/10.3109/01658107.2014.944622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5122973PMC
September 2014
9 Reads

[Near infrared spectroscopy (NIRS) in a neurocritical patient with an air embolisism and pneumocephalus].

Rev Esp Anestesiol Reanim 2015 Feb 28;62(2):96-100. Epub 2014 Aug 28.

Servicio de Anestesiología y Reanimación, Hospital Universitario Ramón y Cajal, Madrid, España.

The pneumocephalus is commonly encountered after neurosurgical procedures. The collections are usually small with benign behavior, and they respond to a conservative therapy. However, there is a high percentage of cases that may behave like a space-occupying lesion. Read More

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http://dx.doi.org/10.1016/j.redar.2014.04.003DOI Listing
February 2015
1 Read

Dyspnea and choking as presenting symptoms in primary medulla oblongata germinoma.

Surg Neurol Int 2014 19;5(Suppl 4):S170-4. Epub 2014 Jun 19.

Division of Neurosurgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, R. O. C.

Background: The medulla oblongata is the lower half of the brainstem. It contains the cardiac, respiratory, vomiting, and vasomotor centers and deals with autonomic functions such as breathing, heartbeat, and blood pressure. Primary medulla oblongata germinoma is very rare and less than 20 cases have been reported in the English literature. Read More

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http://dx.doi.org/10.4103/2152-7806.134815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109171PMC
July 2014
47 Reads

The clinical experience of recurrent central nervous system hemangioblastomas.

Clin Neurol Neurosurg 2014 Aug 29;123:90-5. Epub 2014 May 29.

Department of Radiology, Chonnam National University Medical School, Chonnam National University Hwasun Hospital, Gwangju, South Korea.

Objective: Hemangioblastomas (HBLs) of the central nervous system are benign vascular tumors that may occur sporadically or in von Hippel-Lindau disease (VHLD). We analyzed the clinical and radiological findings of HBLs focusing on recurrence.

Material And Methods: From 1998 to 2012, 36 patients with HBLs were treated. Read More

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http://search.proquest.com/openview/b5ca6d50fee467fd469892e9
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http://linkinghub.elsevier.com/retrieve/pii/S030384671400189
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http://dx.doi.org/10.1016/j.clineuro.2014.05.015DOI Listing
August 2014
23 Reads

Primary medulla oblongata teratomas.

J Neurosurg Pediatr 2014 Sep 4;14(3):296-300. Epub 2014 Jul 4.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Medulla oblongata teratomas are rare. The authors report 2 new cases of teratomas that occurred exclusively in the medulla oblongata. The first case was in a 9-year-old boy who presented with a 6-month history of neck pain and repeated paroxysmal vomiting. Read More

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http://dx.doi.org/10.3171/2014.6.PEDS1423DOI Listing
September 2014
22 Reads

Clinical factors predicting outcomes after surgical resection for sporadic cerebellar hemangioblastomas.

World Neurosurg 2014 Nov 14;82(5):815-21. Epub 2014 Jun 14.

Department of Neurosurgery, Brain Research Institute, University of Niigata, Niigata-City, Japan.

Objective: To determine whether various clinical factors are related to long-term outcomes of patients with sporadic cerebellar hemangioblastomas.

Methods: Subjects included 36 patients (19 men and 17 women) who underwent resection of sporadic hemangioblastoma in the cerebellum. Age at surgery ranged from 17-79 years (mean, 49. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750140056
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http://dx.doi.org/10.1016/j.wneu.2014.06.018DOI Listing
November 2014
7 Reads

A case of cerebellar hemangioblastoma with rhabdoid features.

Brain Tumor Pathol 2015 Apr 1;32(2):145-50. Epub 2014 Jun 1.

Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 6500017, Japan.

We present an unusual case of cerebellar hemangioblastoma characterized by rhabdoid features. The patient was a 35-year-old Japanese man with occipital neuralgia and exacerbating blurred vision. Magnetic resonance imaging revealed a left posterior cranial fossa tumor, which was isointense on T1-weighted images and hyperintense on T2-weighted images with marked homogeneous enhancement. Read More

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http://link.springer.com/content/pdf/10.1007/s10014-014-0193
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http://link.springer.com/10.1007/s10014-014-0193-1
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http://dx.doi.org/10.1007/s10014-014-0193-1DOI Listing
April 2015
3 Reads

Giant solid hemangioblastoma of the cerebellopontine angle: a technically challenging case.

Neurol India 2014 Mar-Apr;62(2):228-9

Department of Neurological Sciences, Christian Medical College, Vellore, Tamil Nadu, India.

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http://dx.doi.org/10.4103/0028-3886.132450DOI Listing
August 2014
8 Reads
4 Citations
1.084 Impact Factor

Symptomatic anterior cerebral artery vasospasm after brainstem hemangioblastoma resection. A case report.

Neuroradiol J 2014 Apr 18;27(2):186-90. Epub 2014 Apr 18.

Neurosurgery Unit, Sant'Agostino Estense Hospital; Modena, Italy.

Diffuse cerebral vasospasm is a rare complication after brain tumour resection as opposed to that following an aneurysmal subarachnoid haemorrhage. Sellar tumours are among the most common pathologies and locations associated with this complication. Removal of posterior cranial fossa lesions is uncommonly associated with vasospasm, with only nine reported cases. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202852PMC
http://dx.doi.org/10.15274/NRJ-2014-10019DOI Listing
April 2014
20 Reads

Intraoperative contrast-enhanced ultrasound for brain tumor surgery.

Neurosurgery 2014 May;74(5):542-52; discussion 552

*Department of Neurosurgery, and ¶ICU, Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy; ‡Department of Radiology, Ospedale Valduce, Como, Italy; §Department of Radiology, Ospedale di Circolo, Busto Arsizio, Italy; ‖Department of Neurological Surgery, Johns Hopkins Medical School, Baltimore, Maryland.

Background: Contrast-enhanced ultrasound (CEUS) is a dynamic and continuous modality that offers a real-time, direct view of vascularization patterns and tissue resistance for many organs. Thanks to newer ultrasound contrast agents, CEUS has become a well-established, live-imaging technique in many contexts, but it has never been used extensively for brain imaging. The use of intraoperative CEUS (iCEUS) imaging in neurosurgery is limited. Read More

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http://dx.doi.org/10.1227/NEU.0000000000000301DOI Listing
May 2014
26 Reads

Prospective natural history study of central nervous system hemangioblastomas in von Hippel-Lindau disease.

J Neurosurg 2014 May 28;120(5):1055-62. Epub 2014 Feb 28.

Surgical Neurology Branch and.

Object: The tumors most frequently associated with von Hippel-Lindau (VHL) disease are hemangioblastomas. While they are associated with significant neurological impairment and mortality, their natural history and optimal management have not been fully defined.

Methods: Patients with VHL were enrolled in a prospective study designed to define the natural history of CNS hemangioblastomas. Read More

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http://dx.doi.org/10.3171/2014.1.JNS131431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4762041PMC
May 2014
7 Reads

Von Hippel-Lindau syndrome: demonstration of entire disease spectrum with (68)Ga-DOTANOC PET-CT.

Korean J Radiol 2014 Jan-Feb;15(1):169-72. Epub 2014 Jan 8.

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India.

Von Hippel-Lindau (VHL) syndrome is a rare neoplastic disorder characterized by central nervous system (CNS) and visceral tumors. We here present (68)Ga-labelled [1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid]-1-Nal3-Octreotide positron emission tomography computed tomography findings in a 52 year old female with VHL syndrome, demonstrating both CNS and visceral tumors. Read More

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http://dx.doi.org/10.3348/kjr.2014.15.1.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909852PMC
April 2014
2 Reads

De novo development and progression of endolymphatic sac tumour in von hippel-lindau disease: an observational study and literature review.

J Neurol Surg B Skull Base 2013 Oct 28;74(5):259-65. Epub 2013 May 28.

Department of Radiology, MRI Zurich, Medical Radiological Institute, Zurich, Switzerland.

Endolymphatic sac tumors (ELST) are rare invasive lesions of the temporal bone that are commonly associated with von Hippel-Lindau disease. This report describes serial magnetic resonance imaging (MRI) and computed tomography (CT) findings over a period of 6 years in a 12-year-old patient who developed an ELST after 3.5 years surveillance for a cerebellar hemangioblastoma. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1347900
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http://dx.doi.org/10.1055/s-0033-1347900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774823PMC
October 2013
7 Reads

Direct transcranial puncture for Onyx embolization of a cerebellar hemangioblastoma.

J Clin Neurosci 2014 Jun 11;21(6):1040-3. Epub 2013 Nov 11.

University of Virginia, Department of Neurological Surgery, University of Virginia Health System, P.O. Box 800212, Charlottesville, VA 22908, USA; University of Virginia, Department of Radiology, Charlottesville, VA, USA. Electronic address:

Intracranial hemangioblastomas are benign but hypervascular tumors, most commonly located in the cerebellum, which are difficult to resect without significant operative blood loss. While preoperative embolization may decrease the amount of operative bleeding, the vascular supply of cerebellar hemangioblastomas frequently precludes safe embolization by an endovascular route due to the risk of thromboembolic vertebrobasilar infarction. Direct puncture embolization overcomes many of the limitations of endovascular embolization but its safety and feasibility for intracranial tumors is unknown. Read More

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http://dx.doi.org/10.1016/j.jocn.2013.08.028DOI Listing
June 2014
3 Reads

[Surgical treatment of hemangioblastoma in medulla oblongata:a report of 12 cases].

Zhonghua Yi Xue Za Zhi 2013 Sep;93(35):2799-802

Shanghai Neurosurgical Institute; Department of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.

Objective: To explore the clinical characteristics, diagnostic strategies and surgical techniques of hemangioblastoma (HB) in medulla oblongata.

Methods: The clinical and radiological characteristics, therapeutic processes and outcomes of 12 HB cases treated at our department from 2002 to 2012 were studied by retrospective analysis.

Results: Headache, somatic numbness and limb muscle weakness were the major symptoms of oblongata HB. Read More

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September 2013
20 Reads

Medullary hemangioblastoma: 34 patients at a single institution.

J Clin Neurosci 2014 Feb 8;21(2):250-5. Epub 2013 Nov 8.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Tiantan Xili 6, Chongwen District, Beijing 100050, People's Republic of China.

This study aimed to elucidate the surgical experience of medullary hemangioblastoma (MH) at a single institution. We reviewed 34 consecutive patients with MH operated on between January 2005 and June 2012 in the neurosurgery department of the Beijing Tiantan Hospital. There were 14 men and 20 women. Read More

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http://dx.doi.org/10.1016/j.jocn.2013.03.037DOI Listing
February 2014
38 Reads