1,350 results match your criteria Brachytherapy[Journal]


Quantifying institutional resource utilization of adjuvant brachytherapy and intensity-modulated radiation therapy for endometrial cancer via time-driven activity-based costing.

Brachytherapy 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiation Oncology, Arizona Oncology, The US Oncology Network, Tucson, AZ. Electronic address:

Purpose: The purpose of this study was to quantify the cost of resources required to deliver adjuvant radiation therapy (RT) for high- to intermediate-risk endometrial cancer using time-driven activity-based costing (TDABC).

Methods And Materials: Comparisons were made for three and five fractions of vaginal cuff brachytherapy (VCB), 28 fractions of intensity-modulated radiation therapy (IMRT), and combined modality RT (25-fraction IMRT followed by 2-fraction VCB). Process maps were developed representing each phase of care. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.03.003DOI Listing

Compendium of fractionation choices for gynecologic HDR brachytherapy-An American Brachytherapy Society Task Group Report.

Brachytherapy 2019 Apr 9. Epub 2019 Apr 9.

Department of Radiation Medicine and Applied Sciences, UC San Diego, La Jolla, CA.

Purpose: The purpose of this study was to report a list of accepted fractionation schemes for high-dose-rate (HDR) brachytherapy for gynecological cancers in a definitive, neoadjuvant, or adjuvant setting.

Methods And Materials: Members of the American Brachytherapy Society (ABS) Task Force with expertise in gynecological brachytherapy reviewed the literature and existing ABS guidelines regarding various dose-fractionation schedules for HDR brachytherapy to create this compendium. Other resources include current guidelines published by medical societies, clinical trials, the published medical literature, and the clinical experience of the ABS Task Force members. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.02.008DOI Listing

Letter to the editor regarding "A systematic review comparing radiation toxicity after various endorectal techniques".

Brachytherapy 2019 Apr 9. Epub 2019 Apr 9.

Department of Radiation Oncology, Leiden University Medical Center LUMC, Leiden, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S15384721193002
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http://dx.doi.org/10.1016/j.brachy.2019.02.006DOI Listing
April 2019
1 Read

Concurrent chemoradiation for cervical cancer: Comparison of LDR and HDR brachytherapy.

Brachytherapy 2019 Jan 14. Epub 2019 Jan 14.

Mallinckrodt Institute of Radiology, St. Louis, MO. Electronic address:

Purpose: To compare clinical outcomes between low-dose-rate (LDR) brachytherapy and high-dose-rate (HDR) brachytherapy for cervical cancer patients.

Methods And Materials: All consecutive newly diagnosed cervical cancer patients undergoing pretreatment 18-fluorodeoxyglucose positron emission tomography imaging and treated with curative-intent definitive chemoradiation from 1997 to 2016 at a U.S. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.11.008DOI Listing
January 2019
1 Read

Radiobiological dose calculation parameters for cervix cancer brachytherapy: A systematic review.

Brachytherapy 2019 Apr 4. Epub 2019 Apr 4.

Division of Medical Physics, Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

The GEC-ESTRO recommendation in cervical cancer treatment planning, including external beam radiotherapy and brachytherapy boosts, is to use radiobiological dose calculations. Such calculations utilize the linear-quadratic model to estimate the effect of multiple cellular response factors and dose delivery parameters. The radiobiological parameters utilized in these calculations are literature values estimated based on clinical and experimental results. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.02.007DOI Listing

Single-fraction brachytherapy as monotherapy for early-stage prostate cancer: The UCSF experience.

Brachytherapy 2019 Apr 3. Epub 2019 Apr 3.

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA. Electronic address:

Purpose: High-dose-rate (HDR) brachytherapy as monotherapy is an effective treatment option for localized prostate cancer, but experience with single-fraction brachytherapy is limited by studies with small sample size. We report a large single-institution experience with single-fraction HDR brachytherapy as monotherapy for early-stage prostate cancer.

Methods And Materials: Retrospective chart review was performed for men treated with HDR brachytherapy as monotherapy for low- to intermediate-risk prostate cancer. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.03.002DOI Listing

I seed implantation for hepatocellular carcinoma with portal vein tumor thrombus: A systematic review and meta-analysis.

Brachytherapy 2019 Apr 3. Epub 2019 Apr 3.

Department of oncology, Hebei General Hospital, Shijiazhuang, Hebei, China. Electronic address:

Purpose: Advanced hepatocellular carcinoma often combined with portal vein tumor thrombus (PVTT), transcatheter arterial chemoembolization (TACE) is recommended as an effective treatment. Recent studies showed that TACE plus iodine-125 (I) seed for hepatocellular carcinoma with PVTT can improve the remission rate. This study aimed to systematically evaluate the efficacy and safety of I seed implantation in patients with PVTT. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.014DOI Listing
April 2019
2 Reads

Optimization of HDRBT boost dose delivery for patients with rectal cancer.

Brachytherapy 2019 Mar 23. Epub 2019 Mar 23.

Radiation Oncology Department, Jewish General Hospital, Montreal, Quebec, Canada; Oncology Department, McGill University, Montreal, Quebec, Canada; Segal Cancer Centre, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.

Purpose: We describe methods to improve dose delivery for patients with rectal cancer receiving boost brachytherapy after external beam radiotherapy.

Methods And Materials: Patients with rectal cancer who were ineligible or refusing surgery are treated with external beam radiotherapy and subsequently with three weekly image-guided volume-adapted high-dose-rate brachytherapy boosts of 10 Gy to the residual clinical target volume, for a total of 30 Gy in three fractions. Tungsten shielding placed at the center of intracavitary mold applicator and double-balloon technique was used to improve dose conformity to the target. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183067
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http://dx.doi.org/10.1016/j.brachy.2019.02.001DOI Listing
March 2019
3 Reads

Combining brachytherapy and immunotherapy to achieve in situ tumor vaccination: A review of cooperative mechanisms and clinical opportunities.

Brachytherapy 2019 Mar - Apr;18(2):240

Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI.

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http://dx.doi.org/10.1016/j.brachy.2019.01.004DOI Listing

Brachytherapy: Expanding the horizons.

Brachytherapy 2019 Mar 16. Epub 2019 Mar 16.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland, OH; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, NewYork, NY.

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http://dx.doi.org/10.1016/j.brachy.2019.01.003DOI Listing

Second breast-conserving surgery and interstitial brachytherapy vs. salvage mastectomy for the treatment of local recurrences: 5-year results.

Brachytherapy 2019 Mar 16. Epub 2019 Mar 16.

Centre of Radiotherapy, National Institute of Oncology, Budapest, Hungary; Department of Oncology, Semmelweis University, Faculty of Medicine, Budapest, Hungary.

Purpose: The purpose of this study was to report the clinical outcomes of a second breast-conserving therapy (2nd BCT) with perioperative interstitial brachytherapy (iBT) vs. those of salvage mastectomy (sMT) in the treatment of ipsilateral breast tumor recurrences (IBTRs).

Methods And Materials: Between 1999 and 2015, 195 patients with IBTR after a previous breast-conserving treatment were salvaged either with reexcision and perioperative high-dose-rate iBT (n = 39), or with sMT (n = 156). Read More

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http://dx.doi.org/10.1016/j.brachy.2019.02.004DOI Listing

Permanent prostate brachytherapy is safe in men with severe baseline lower urinary tract symptoms.

Brachytherapy 2019 Mar 16. Epub 2019 Mar 16.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Purpose: To evaluate the long-term urinary outcomes of men with severe pretreatment lower urinary tract symptoms (LUTS) treated with permanent prostate brachytherapy (PPB) ± external beam radiation therapy for localized prostate cancer.

Methods And Materials: A total of 105 men with International Prostate Symptom Score (IPSS) 20-35 before PPB were categorized by IPSS change at last followup: (1) worse = IPSS rise >3; (2) no change = IPSS change within three points of baseline; (3) improved = IPSS fall by >3 points. We then evaluated patients who worsened vs. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.02.002DOI Listing
March 2019
1.987 Impact Factor

Variations in patterns of concurrent androgen deprivation therapy use based on dose escalation with external beam radiotherapy vs. brachytherapy boost for prostate cancer.

Brachytherapy 2019 Mar 9. Epub 2019 Mar 9.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA.

Purpose: Retrospective data suggest less benefit from androgen deprivation therapy (ADT) in the setting of dose-escalated definitive radiation for prostate cancer, especially when a combination of external beam radiotherapy (EBRT) and brachytherapy approaches are used. This study aimed to test the hypothesis that patients with prostate cancer with intermediate- or high-risk disease undergoing extreme dose escalation with a brachytherapy boost are less likely to receive ADT.

Methods And Materials: Data from the National Cancer Database were extracted for men aged 40-90 years diagnosed with node-negative, non-metastatic prostate cancer from 2004 to 2015. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.016DOI Listing
March 2019
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Reducing seed migration to near zero with stranded-seed implants: Comparison of seed migration rates to the chest in 1000 permanent prostate brachytherapy patients undergoing implants with loose or stranded seeds.

Brachytherapy 2019 Mar 7. Epub 2019 Mar 7.

Department of Radiation Oncology, Mayo Clinic, Rochester, MN.

Purpose: Pulmonary seed emboli to the chest may occur after permanent prostate brachytherapy (PPB). The purpose of this study is to analyze factors associated with seed migration to the chest in a large series of PPB patients from a single institution undergoing implant with either loose seeds (LS), mixed loose and stranded seeds (MS), or exclusively stranded seeds in an absorbable vicryl suture (VS).

Methods And Materials: Between May 1998 and July 2015, a total of 1000 consecutive PPB patients with postoperative diagnostic chest x-rays at 4 months after implant were analyzed for seed migration. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.007DOI Listing
March 2019
1 Read

Intraoperative brachytherapy for resected brain metastases.

Brachytherapy 2019 Mar 5. Epub 2019 Mar 5.

Stich Radiation Oncology, Weill Medical College of Cornell University, New York, NY; Department of Neurosurgery, Weill Medical College of Cornell University, New York, NY. Electronic address:

Brain metastases are the most common intracranial malignancies in adults. Surgical resection is the preferred treatment approach when a pathological diagnosis is required, for symptomatic patients who are refractory to steroids, and to decompress lesions causing mass effect. Radiotherapy is administered to improve local control rates after surgical resection. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.011DOI Listing
March 2019
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Improved survival for patients with prostate cancer receiving high-dose-rate brachytherapy boost to EBRT compared with EBRT alone.

Brachytherapy 2019 Mar 4. Epub 2019 Mar 4.

Alfred Health Radiation Oncology, Alfred Hospital, Melbourne, Victoria, Australia; Department of Surgery, Central Clinical School, Monash University, The Alfred Centre, Melbourne, Victoria, Australia. Electronic address:

Purpose: High-dose-rate (HDR) brachytherapy boost is a treatment of intermediate- to high-risk prostate cancer, but long-term clinical outcome data are sparse. We report long-term survival and toxicity data in a cohort of patients treated in a single institution.

Methods: Between 1998 and 2004, 654 patients with localized prostate cancer received either 3-dimensional conformal radiotherapy (median 46 Gy) with an HDR (median 18 Gy in three fractions) boost ("3-D conformal radiotherapy [3DCRT] + HDR"; 215 patients) or 3DCRT alone ("3DCRT"; median 70 Gy; 439 patients) with curative intent. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.013DOI Listing
March 2019
2 Reads

Implementation of an HDR brachytherapy-based breast IORT program: Initial experiences.

Brachytherapy 2019 Mar 4. Epub 2019 Mar 4.

Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA. Electronic address:

Purpose: A multidisciplinary team at our institution developed a novel method of intraoperative breast radiation therapy (precision breast intraoperative radiation therapy [PB-IORT]) that uses high-dose-rate brachytherapy with CT on-rails imaging to deliver high-dose, customized radiotherapy to patients with early-stage breast cancer. This report summarizes our program's experience developing and implementing PB-IORT.

Methods And Materials: Literature on PB-IORT was reviewed including published articles and abstracts. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.02.005DOI Listing

Novel intraoperative radiotherapy utilizing prefabricated custom three-dimensionally printed high-dose-rate applicators.

Brachytherapy 2019 Feb 22. Epub 2019 Feb 22.

Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY.

Background: Intraoperative radiotherapy (IORT) is an effective strategy for the delivery of high doses of radiotherapy to a residual tumor or resection cavity with relative sparing of nearby healthy tissues. This strategy is an important component of the multimodality management of pediatric soft tissue sarcomas, particularly in cases where patients have received prior courses of external beam radiotherapy.

Purpose: Tumor beds with significant topographic irregularity remain a therapeutic challenge because existing IORT technologies are typically most reliable with flat surfaces. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.012DOI Listing
February 2019

Dosimetric comparison of circular Eye Physics and Collaborative Ocular Melanoma Study plaques to treat uveal melanoma.

Brachytherapy 2019 Feb 20. Epub 2019 Feb 20.

Department of Radiation Oncology, University of Miami/Jackson Memorial Hospital, Miami, FL. Electronic address:

Purpose: We sought to formally compare Collaborative Ocular Melanoma Study (COMS) and similar-shaped (circular) eye physics (EP) plaques dosimetrically by examining both tumor coverage and critical structure doses.

Methods And Materials: The plans of patients with uveal melanoma treated consecutively with eye plaque brachytherapy at a single institution from January 2016 to December 2017 were reviewed. Both a COMS plan and an EP plan using plaques of the same shape were generated for each patient using the Isoaid Plaque Simulator software such that >90% of the tumor + 2 mm margin received 85 Gy over 72 hours from iodine-125 sources. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.005DOI Listing
February 2019
3 Reads

Radiobiological optimization comparison between pulse-dose-rate and high-dose-rate brachytherapy in patients with locally advanced cervical cancer.

Brachytherapy 2019 Feb 20. Epub 2019 Feb 20.

Radiotherapy Department, Brachytherapy Unit, Gustave Roussy Cancer Campus, Villejuif, France; INSERM U1030, Gustave Roussy Cancer Campus, Villejuif, France; Faculté de médecine PARIS Sud, université Paris Sud, Université Paris Saclay, Paris, France; French Military Health Services Academy, Ecole du Val-de-Grâce, Paris, France; Institut de Recherche Biomédicale des Armées, Bretigny-sur-Orge, France. Electronic address:

Purpose: Only scarce data are available on the possibility to include radiobiological optimization as part of the dosimetric process in cervical cancer treated with brachytherapy (BT). We compared dosimetric outcomes of pulse-dose-rate (PDR) and high-dose-rate (HDR)-BT, according to linear-quadratic model.

Methods And Materials: Three-dimensional dosimetric data of 10 consecutive patients with cervical cancer undergoing intracavitary image-guided adaptive PDR-BT after external beam radiation therapy were examined. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183062
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http://dx.doi.org/10.1016/j.brachy.2018.12.009DOI Listing
February 2019
4 Reads

The confidence interval reported in this study appears to be an error.

Authors:
W Robert Lee

Brachytherapy 2019 Feb 20. Epub 2019 Feb 20.

Professor of Radiation Oncology, Duke University School of Medicine, Durham, NC.

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http://dx.doi.org/10.1016/j.brachy.2019.01.009DOI Listing
February 2019

Dose to the dominant intraprostatic lesion using HDR vs. LDR monotherapy: A Phase II randomized trial.

Brachytherapy 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, Kelowna General Hospital, Kelowna, British Columbia, Canada.

Purpose: To present the dosimetric results of a Phase II randomized trial comparing dose escalation to the MRI-defined dominant intraprostatic lesion (DIL) using either low-dose-rate (LDR) or high-dose-rate (HDR) prostate brachytherapy.

Material And Methods: Patients receiving prostate brachytherapy as monotherapy were randomized to LDR or HDR brachytherapy. Prostate and DILs were contoured on preoperative multiparametric MRI. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.006DOI Listing
February 2019
1 Read

Monte Carlo study of the relationship between skin dose and optically stimulated luminescence dosimeter dose in Pd-103 permanent breast seed implant brachytherapy.

Brachytherapy 2019 Feb 18. Epub 2019 Feb 18.

Department of Physics and Astronomy, University of Calgary, Calgary Alberta, Canada; Department of Medical Physics, Royal Devon and Exeter Hospital NHS, Exeter, Devon, UK.

Purpose: To establish a method for estimating skin dose for patients with permanent breast seed implant based on in vivo optically stimulated luminescence dosimeters (OSLDs) measurements.

Methods And Materials: Monte Carlo simulations were performed in a simple breast phantom using the EGSnrc user code egs_brachy. Realistic models of the IsoAid Advantage Pd-103 brachytherapy source and Landauer nanoDot OSLD were created to model in vivo skin dose measurements where an OSLD would be placed on the skin of a patient with permanent breast seed implant following implantation. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.008DOI Listing
February 2019
1 Read

I seeds implantation for treating residual hepatocellular carcinoma located beneath the diaphragm after transcatheter arterial chemoembolization.

Brachytherapy 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiology, The Affiliated Hospital of Jiangnan University, Wuxi 4th People's Hospital, Jiangsu Province, Wuxi, China.

Purpose: The effect of I seed implantation for the treatment of local residual tumor of hepatocellular carcinoma located beneath the diaphragm (HCC-LBD) after transcatheter arterial chemoembolization (TACE) has not yet been reported. This retrospective study was performed to evaluate the safety and efficacy of I seeds implantation (ISI) for the treatment of residual HCC-LBD after TACE.

Methods And Materials: A total of 18 patients treated with ISI between August 2012 and March 2018 for residual HCC-LBD after single or multiple TACE were enrolled. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.008DOI Listing
February 2019
3 Reads
1.987 Impact Factor

Factors associated with deformation accuracy and modes of failure for MRI-optimized cervical brachytherapy using deformable image registration.

Brachytherapy 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, CA. Electronic address:

Purpose: To identify factors associated with MRI-to-CT image deformation accuracy and modes of failure for MRI-optimized intracavitary high-dose-rate treatment of locally advanced cervical cancer.

Methods And Materials: Twenty-six patients with locally advanced cervical cancer had preimplantation MRI registered and deformed to postimplantation CT images using anatomically constrained and biomechanical model-based deformable image registration (DIR) algorithms. Cervix (primary) and cervix plus 10-mm margin (secondary) were used as controlling regions of interest for deformation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183068
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http://dx.doi.org/10.1016/j.brachy.2019.01.001DOI Listing
February 2019
6 Reads

Understanding the underutilization of cervical brachytherapy for locally advanced cervical cancer.

Brachytherapy 2019 Feb 2. Epub 2019 Feb 2.

Department of Radiation Medicine, University of California San Diego School of Medicine, San Diego, CA. Electronic address:

Purpose: To understand the reasons behind current low utilization of brachytherapy for locally advanced cervical cancer in the United States.

Methods And Materials: A 17-item survey was e-mailed to the American Brachytherapy Society (ABS) listserv of active members in 2018. Responses of attending physicians in the United States were included in the analysis. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.002DOI Listing
February 2019
1 Read
1.987 Impact Factor

Evaluation of bi-objective treatment planning for high-dose-rate prostate brachytherapy-A retrospective observer study.

Brachytherapy 2019 Feb 1. Epub 2019 Feb 1.

Department of Radiation Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Purpose: Bi-objective treatment planning for high-dose-rate prostate brachytherapy is a novel treatment planning method with two separate objectives that represent target coverage and organ-at-risk sparing. In this study, we investigated the feasibility and plan quality of this method by means of a retrospective observer study.

Methods And Materials: Current planning sessions were recorded to configure a bi-objective optimization model and to assess its applicability to our clinical practice. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.010DOI Listing
February 2019

Optimized penile surface mold brachytherapy using latest stereolithography techniques: A single-institution experience.

Brachytherapy 2019 Feb 1. Epub 2019 Feb 1.

University of Toronto, Toronto, Ontario, Canada; Department of Radiation Oncology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. Electronic address:

Purpose: To describe a technique of penile surface mold high-dose-rate (HDR) brachytherapy and early outcomes.

Methods And Materials: Five patients diagnosed with a T1aN0 squamous cell carcinoma of the penis were treated using a penile surface mold HDR brachytherapy technique. A negative impression of the penis was obtained using dental alginate. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.01.002DOI Listing
February 2019
3 Reads
1.987 Impact Factor

Brachytherapy: A critical component of primary radiation therapy for cervical cancer: From the Society of Gynecologic Oncology (SGO) and the American Brachytherapy Society (ABS).

Brachytherapy 2019 Mar - Apr;18(2):123-132. Epub 2019 Jan 18.

Radiation Oncology, UC San Diego School of Medicine, San Diego, CA.

Brachytherapy is well-established as an integral component in the standard of care for treatment of patients receiving primary radiotherapy for cervical cancer. A decline in brachytherapy has been associated with negative impacts on survival in the era of modern EBRT techniques. Conformal external beam therapies such intensity modulated radiation therapy (IMRT) or stereotactic body radiation therapy (SBRT) should not be used as alternatives to brachytherapy in patients undergoing primary curative-intent radiation therapy for cervical cancer. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.11.009DOI Listing
January 2019

Correlation between real-time intraoperative and postoperative dosimetry and its implications on intraoperative planning.

Brachytherapy 2019 Jan 14. Epub 2019 Jan 14.

Department of Radiation Oncology, UPMC Hillman Cancer Center, Pittsburgh, PA.

Purpose: The purpose of this study was to study the correlation between intraoperative and postimplant dosimetry. We investigated the correlation between prostate (V) and urethra (D, D) dose limits, and whether it is possible to increase prostate D and V in intraoperative planning without violating postimplant urethra and rectum dose limits.

Methods And Materials: Seventy-nine patients who underwent real-time ultrasound-guided prostate implants using intraoperative planning from 2013 to 2017 were analyzed. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.004DOI Listing
January 2019
2 Reads

A comparative analysis of overall survival between high-dose-rate and low-dose-rate brachytherapy boosts for unfavorable-risk prostate cancer.

Brachytherapy 2019 Mar - Apr;18(2):186-191. Epub 2019 Jan 10.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Purpose: External beam radiation therapy (EBRT) with low-dose-rate (LDR) brachytherapy boost has been associated with improved biochemical progression-free survival and overall survival (OS) compared with dose-escalated EBRT (DE-EBRT) alone for unfavorable-risk prostate cancer. However, it is not known whether high-dose-rate (HDR) boost provides a similar benefit. We compare HDR boost against LDR boost and DE-EBRT with respect to OS. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.007DOI Listing
January 2019
2 Reads

Evaluation of the accuracy of computer-assisted techniques in the interstitial brachytherapy of the deep regions of the head and neck.

Brachytherapy 2019 Mar - Apr;18(2):217-223. Epub 2019 Jan 9.

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Haidian District, Beijing, PR China. Electronic address:

Purpose: We sought to investigate the feasibility and accuracy of computer-assisted techniques in the interstitial brachytherapy of the deep regions of the head and neck.

Materials And Methods: A computer-assisted brachytherapy workflow was applied to 10 patients with tumors in the deep regions of the head and neck. Based on the brachytherapy treatment preplan, we constructed a digital stereotactic model to accurately transfer the virtual plan into the navigation system, and subsequently printed the individual templates. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.003DOI Listing
January 2019
3 Reads

Evaluating the influence of prostate-specific antigen kinetics on metastasis in men with PSA recurrence after partial gland therapy.

Brachytherapy 2019 Mar - Apr;18(2):198-203. Epub 2019 Jan 10.

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.

Purpose: Although current Delphi Consensus guidelines do not recommend a specific definition of biochemical recurrence after partial gland therapy, these guidelines acknowledge that serial prostate-specific antigen (PSA) tests remain the best marker for monitoring disease after treatment. The purpose of this study was to determine whether PSA velocity at failure per the Phoenix (nadir + 2 ng/mL) definition is associated with metastasis and prostate cancer-specific mortality (PCSM) in a cohort of patients who experienced PSA failure after partial gland therapy.

Methods: Between 1997 and 2007, 285 patients with favorable risk prostate cancer underwent partial prostate brachytherapy to the peripheral zone. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.001DOI Listing
January 2019
1 Read

Long-term oncological and functional outcomes support use of low-dose-rate brachytherapy with or without external beam radiation in young men (≤60 years) with localized prostate cancer.

Brachytherapy 2019 Mar - Apr;18(2):192-197. Epub 2019 Jan 8.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Purpose: To evaluate the oncological and functional outcomes of young men treated with low-dose-rate brachytherapy (BT) for prostate cancer (PCa).

Materials And Methods: 423 men aged ≤60 years with clinically localized PCa were treated with BT ± external beam radiation. Biochemical failure was defined by Phoenix criteria. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.12.005DOI Listing
January 2019
2 Reads

Dosimetric study of CO-60 source step size in uterine cervix intracavitary HDR brachytherapy.

Brachytherapy 2019 Mar - Apr;18(2):180-185. Epub 2019 Jan 5.

Department of Physics, G.G.D.S.D. College, Chandigarh, India.

Purpose: The present work reports effects of source step sizes on dose distribution in patients treated with cobalt-60 (Co-60) high-dose-rate afterloading brachytherapy in carcinoma cervix (Ca-cx).

Methods And Materials: The retrospective study is based on data of 15 patients of Ca-cx treated with Co-60 high-dose-rate intracavitary brachytherapy with dose of 21 Gy in three fractions with source step size of 2.5 mm after external beam radiotherapy of 46 Gy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183054
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http://dx.doi.org/10.1016/j.brachy.2018.12.006DOI Listing
January 2019
8 Reads
1.987 Impact Factor

Comparison of the prognostic value of F-18 FDG PET/CT metabolic parameters of primary tumors and MRI findings in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy.

Brachytherapy 2019 Mar - Apr;18(2):154-162. Epub 2018 Dec 26.

Health Sciences University, Sisli Hamidiye Etfal Training and Research Hospital, Radiation Oncology Department, Istanbul, Turkey.

Purpose: To evaluate the effect of metabolic parameters of pretreatment primary tumor and regional lymph nodes with F-18-FDG PET/CT compared with MRI findings for the prognostic value and disease-free survival (DFS) in locally advanced cervical cancer.

Material And Methods: From 2011 to 2016, 112 patients with a diagnosis of cervical cancer stages IB2-IVA treated with concomitant chemoradiation therapy with 3D intracavitary brachytherapy were analyzed. From this group, 50 patients who underwent pretreatment and posttreatment FDG PET/CT and MRI were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183006
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http://dx.doi.org/10.1016/j.brachy.2018.11.005DOI Listing
December 2018
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Use of interstitial brachytherapy in pelvic recurrence of cervical carcinoma: Clinical response, survival, and toxicity.

Brachytherapy 2019 Mar - Apr;18(2):146-153. Epub 2018 Dec 24.

Department of Obstetrics and Gynecology, University of Campinas (Unicamp), Campinas, Sao Paulo, Brazil. Electronic address:

Purpose: The purpose of this study was to evaluate clinical response, postrecurrence survival, disease-free survival (DFS), and toxicity related to reirradiation in pelvic recurrence of cervical carcinoma.

Methods And Materials: A retrospective cohort study of 45 women undergoing high-dose-rate interstitial brachytherapy (HDR-IB) was conducted from 1998 to 2014. Clinical information, as well as data on the malignancy, primary treatment, HDR-IB technique, and toxicity, was collected. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.11.002DOI Listing
December 2018
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MRI-guided adaptive brachytherapy for locally advanced cervix cancer: Treatment outcomes from a single institution in Hong Kong.

Brachytherapy 2019 Mar - Apr;18(2):171-179. Epub 2018 Dec 21.

Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong.

Background: Paradigm has shifted from 2D to image-guided adaptive brachytherapy (IGABT) for locally advanced cervix cancer (LACC). Increasing reports from pioneering institutions and large retrospective multicenter series have demonstrated improvements in outcome and reduction in toxicity with IGABT. However, there is scarcity of data on magnetic resonance (MR)-IGABT in Chinese patients. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.11.007DOI Listing
December 2018
3 Reads

Brachytherapy and survival in small cell cancer of the cervix and uterus.

Brachytherapy 2019 Mar - Apr;18(2):163-170. Epub 2018 Dec 15.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO. Electronic address:

Purpose: Small cell cancer involving the cervix and uterus is considered the same rare disease, but management is controversial and disparate. Patterns of care and outcomes in the United States are unclear.

Methods And Materials: Clinical data from patients with small cell cancer of the cervix and uterus were abstracted from the National Cancer Database from 2004 to 2014. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.11.006DOI Listing
December 2018
2 Reads

Long-term results of multicatheter interstitial high-dose-rate brachytherapy for accelerated partial-breast irradiation.

Brachytherapy 2019 Mar - Apr;18(2):211-216. Epub 2018 Dec 13.

Département de radio-oncologie, Centre Intégré de Santé et de Services Sociaux de l'Outaouais, Gatineau, Quebec, Canada.

Purpose: The purpose of this study was to report the long-term results of women treated in one center with accelerated partial-breast irradiation (APBI) with interstitial high-dose-rate (HDR) brachytherapy.

Materials And Methods: We analyzed data from women treated in one center with adjuvant interstitial HDR brachytherapy for early-stage breast cancer. Treatment regimen was homogeneous for all women with treatment dose 32Gy in 8 fractions twice daily given to the tumor bed with interstitial HDR brachytherapy. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.11.004DOI Listing
December 2018
1 Read

Development and dosimetric assessment of a patient-specific elastic skin applicator for high-dose-rate brachytherapy.

Brachytherapy 2019 Mar - Apr;18(2):224-232. Epub 2018 Dec 7.

Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea; Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: The purpose of this study was to develop a patient-specific elastic skin applicator and to evaluate its dosimetric characteristics for high-dose-rate (HDR) brachytherapy.

Methods And Materials: We simulated the treatment of a nonmelanoma skin cancer on the nose. An elastic skin applicator was manufactured by pouring the Dragon Skin (Smooth-On Inc. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.11.001DOI Listing
December 2018
3 Reads

Subcutaneous spacer injection to reduce skin toxicity in breast brachytherapy: A pilot study on mastectomy specimens.

Brachytherapy 2019 Mar - Apr;18(2):204-210. Epub 2018 Dec 5.

Department of Surgery, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands.

Purpose: Accelerated partial breast irradiation is a treatment option for selected patients with early-stage breast cancer. Some accelerated partial breast irradiation techniques lead to skin toxicity with the skin dose as a main risk factor. Biodegradable spacers are effective and safe in prostate brachytherapy to protect the rectum. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183055
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http://dx.doi.org/10.1016/j.brachy.2018.11.003DOI Listing
December 2018
12 Reads

Risk analysis of electronic intraoperative radiation therapy for breast cancer.

Brachytherapy 2018 Nov 29. Epub 2018 Nov 29.

UC San Diego Radiation Medicine and Applied Sciences, La Jolla, CA. Electronic address:

Purpose: To evaluate the process and improve safety of intraoperative radiation therapy (IORT) for early-stage breast cancers treated with electronic brachytherapy.

Methods And Materials: A multidisciplinary team conducted a failure mode and effects analysis (FMEA) for IORT breast cancer treatments by first developing a process map. This map was then used to identify failure modes for all steps in the treatment workflow. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183062
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http://dx.doi.org/10.1016/j.brachy.2018.10.007DOI Listing
November 2018
5 Reads

Patient-reported sexual adjustment after definitive chemoradiation and MR-guided brachytherapy for cervical cancer.

Brachytherapy 2019 Mar - Apr;18(2):133-140. Epub 2018 Nov 30.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, University Health Network, Toronto, Ontario, Canada. Electronic address:

Purpose: The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical cancer treated with CRT and MR-guided brachytherapy (BT).

Materials And Methods: Between 2008 and 2010, International Federation of Gynecologists and Obstetricians stage IB-IVA patients with cervical cancer receiving definitive CRT were enrolled in a feasibility study assessing MR-guided BT. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.09.005DOI Listing
November 2018
10 Reads

The American Brachytherapy Society consensus statement for electronic brachytherapy.

Brachytherapy 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Purpose: Brachytherapy is utilized in the treatment of many different malignancies; although traditionally performed with low-dose-rate or high-dose-rate techniques, more recently, electronic brachytherapy (EB) has emerged as a potential alternative. At this time, there are no evidence-based guidelines to assist clinicians in patient selection for EB and concerns exits regarding differences in dosimetry as compared to traditional brachytherapy techniques. As such, the American Brachytherapy Society appointed a group of physicians and physicists to create a consensus statement regarding the use of EB. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183067
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http://dx.doi.org/10.1016/j.brachy.2018.10.006DOI Listing
November 2018
12 Reads

Impact on treatment time of MRI-based brachytherapy in two implants (4 doses) compared with CT-based brachytherapy in five implants for cervical cancer.

Brachytherapy 2019 Mar - Apr;18(2):141-145. Epub 2018 Nov 26.

Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL. Electronic address:

Purpose: Concurrent chemoradiotherapy and brachytherapy is the standard of care for locally advanced cervical cancer. Brachytherapy is an integral part of treatment and has improved overall survival. Research is needed to ascertain the planning modalities and schedules to best use resources and optimize treatment time course. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.10.005DOI Listing
November 2018
14 Reads

Comparison of two iodine-125 brachytherapy implant techniques for the treatment of lung tumor: Preplanning and intraoperative planning.

Brachytherapy 2019 Jan - Feb;18(1):87-94. Epub 2018 Oct 25.

Cancer Therapy and Research Center, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, PR China. Electronic address:

Purpose: To compare preplanning and intraoperative planning methods of lung tumor brachytherapy based on postimplant CT images and dosimetric outcomes.

Methods And Materials: Detailed postimplant evaluations of iodine-125 seed implants were performed in 15 patients using a preplanning technique and in 15 patients treated with an intraoperative planning technique. The implant details, dosimetric parameters, and implant quality indices were compared. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.08.007DOI Listing
October 2018
4 Reads

Radical dose escalation by high-dose-rate brachytherapy for localized prostate cancer-Significance of prostate-specific antigen nadir level within 18 months as correlation for long-term biochemical control.

Brachytherapy 2019 Jan - Feb;18(1):8-12. Epub 2018 Oct 25.

Christian-Albrechts-University Kiel, Medical Faculty, Kiel, Germany. Electronic address:

Purpose: High-dose-rate brachytherapy (HDR-BT) for dose escalation in localized prostate cancer has been established as one standard treatment option. However, long-term results at followup (FU) ≥5 years are usually needed to ensure robustness of reported outcomes. Potential benefit of salvage therapy is, nevertheless, higher when relapse is diagnosed early. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.08.013DOI Listing
October 2018
4 Reads

Predictive factors of benefit from iodine-125 brachytherapy for hepatocellular carcinoma with portal vein tumor thrombosis.

Brachytherapy 2019 Mar - Apr;18(2):233-239. Epub 2018 Nov 19.

Department of Interventional Radiology, Fujian Medical University Union Hospital, Fuzhou, China. Electronic address:

Purpose: The aims of this study were to evaluate treatment responses and predictive factors for overall survival (OS) in hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) treated with iodine-125 (I) brachytherapy.

Methods And Materials: Seventy-seven HCC patients with PVTT underwent I brachytherapy after transcatheter arterial chemoembolization. Clinical, laboratory, and radiological evaluation were performed before and after treatment, as well as at 4-6 weeks intervals for 7 years to assess the efficacy and toxicity of therapy. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.10.002DOI Listing
November 2018
12 Reads

Prostate brachytherapy under hypnosedation: A prospective evaluation.

Brachytherapy 2019 Jan - Feb;18(1):22-28. Epub 2018 Nov 10.

Department of Anesthesiology, Centre Hospitalier Lyon Sud, Pierre-Benite, France.

Purpose: Hypnosedation (HS) for brachytherapy has been proposed in patients with prostate cancer and has been evaluated.

Materials And Methods: 79 patients were treated with brachytherapy under HS. The Visual Analog Scale questionnaire was used to assess comfort and anxiety and the lowest, mean, and highest level of pain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183054
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http://dx.doi.org/10.1016/j.brachy.2018.10.004DOI Listing
November 2018
13 Reads