23,533 results match your criteria Brachytherapy [Journal]


Impact of cancer service centralisation on the radical treatment of men with high-risk and locally advanced prostate cancer: A national cross-sectional analysis in England.

Int J Cancer 2018 Dec 14. Epub 2018 Dec 14.

Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine.

In many countries, specialist cancer services are centralised to improve outcomes. We explored how centralisation affects the radical treatment of high-risk and locally advanced prostate cancer in the English NHS. 79,085 patients diagnosed with high-risk and locally advanced prostate cancer in England (April 2014 to March 2016) were identified in the National Prostate Cancer Audit database. Read More

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December 2018

3D-printed Vaginal Applicators for Electronic Brachytherapy of Endometrial Cancers.

Med Phys 2018 Dec 13. Epub 2018 Dec 13.

Department of Nuclear and Quantum Engineering, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Republic of Korea.

Purpose: Vaginal applicators for a novel miniature X-ray tube were developed using three-dimensional (3D) printing to be used in brachytherapy of endometrial cancers.

Methods: Cylindrical vaginal applicators with various diameters, lengths, and infill percentages (IFPs) were fabricated using a 3D printer. X-ray dose distributions and depth-dose profiles were calculated using a Monte Carlo simulation. Read More

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December 2018

Changes in lower urinary tract symptoms after iodine-125 brachytherapy for prostate cancer.

Clin Transl Radiat Oncol 2019 Jan 17;14:51-58. Epub 2018 Nov 17.

Department of Urology, Nara Medical University, Japan.

Purpose: To investigate chronological changes in lower urinary tract symptoms (LUTS) in patients who received iodine-125 brachytherapy (BT) for prostate cancer.

Methods: We enrolled 706 patients who received BT. Of these, 265 (38%) received BT combined with external beam radiation therapy (EBRT). Read More

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January 2019
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Bright insights into palladium-triggered local chemotherapy.

Chem Sci 2018 Oct 17;9(37):7354-7361. Epub 2018 Jul 17.

Cancer Research UK Edinburgh Centre , Institute of Genetics and Molecular Medicine , University of Edinburgh , Crewe Road South , Edinburgh EH4 2XR , UK . Email:

The incorporation of transition metal catalysts to the bioorthogonal toolbox has opened the possibility of producing supra-stoichiometric amounts of xenobiotics in living systems in a non-enzymatic fashion. For medical use, such metals could be embedded in implantable devices ( heterogeneous catalyst) to "synthesize" drugs in desired locations ( in a tumour) with high specificity and for extended periods of time, overcoming the useful life limitations of current local therapy modalities directed to specific organ sites ( brachytherapy, controlled release systems). To translate this approach into a bona fide therapeutic option, it is essential to develop clinically-accessible implantation procedures and to understand and validate the activation process in relevant preclinical models. Read More

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October 2018

Ciliary body melanoma treatment by stereotactic radiosurgery.

Cesk Slov Oftalmol 2018 ;73(5-6):204-210

Introduction: Malignant melanoma of the ciliary body (corpus ciliare) represents 10 to 15 percent of tumors of the uveal tract. The aim of the work is to evaluate the effectiveness of stereotactic radiosurgery performed on LINAC linear accelerator and the occurrence of postoperative complications.

Material And Methods: Retrospective analysis of patients with ciliary body melanoma treated with stereotactic radiosurgery on linear accelerator in the period 1/2011 to 12/2016 in Slovakia. Read More

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January 2018

Outcomes of Adjuvant Therapy for Stage IA Serous Endometrial Cancer.

Cureus 2018 Sep 29;10(9):e3387. Epub 2018 Sep 29.

Radiation Oncology, Juravinski Cancer Centre-McMaster University, Hamilton, CAN.

Purpose: Serous adenocarcinoma is a rare, aggressive histologic subtype of endometrial cancer with a high rate of recurrence and a poor prognosis. The optimal adjuvant treatment for early-stage patients is unclear. Our objective was to evaluate the outcomes of stage IA serous endometrial cancers only treated at a single institution and determine whether our current approach of chemotherapy plus vaginal brachytherapy (VBT) is sufficient. Read More

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September 2018

Dosimetry of indigenously developed 177Lu patch source for surface brachytherapy - Experimental and Monte Carlo methods.

J Radiol Prot 2018 Nov 6. Epub 2018 Nov 6.

Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, INDIA.

This paper describes the evaluation of dosimetry characteristics of an in-house developed 177Lu skin patch source for treatment of non-melanoma skin cancer. A 177Lu skin patch source based on Nafion-115 membrane backbone containing 3.46 ± 0. Read More

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November 2018

Silodosin: An Update on Efficacy, Safety and Clinical Indications in Urology.

Adv Ther 2018 Dec 6. Epub 2018 Dec 6.

Division of Experimental Oncology/Unit of Urology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.

Introduction: Silodosin determines smooth muscle relaxation in bladder and prostate tissues, increases bladder blood flow in conditions of chronic bladder ischemia and regulates the activity of transcriptional factors responsible for stromal growth and prostate hyperplasia. Phase III trials have already demonstrated the efficacy and safety of silodosin in the treatment of patients bothered by lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH).

Objective: We aimed to describe the rationality for the use of silodosin and to summarize the current literature on the use of Silodosin for the treatment of LUTS. Read More

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December 2018

Re-irradiation for recurrent glioblastoma (GBM): a systematic review and meta-analysis.

J Neurooncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, National University Cancer Institute Singapore, National University Hospital, Singapore, 119228, Singapore.

Purpose: To determine the efficacy and toxicity of re-irradiation for patients with recurrent GBM.

Materials And Methods: We searched various biomedical databases from 1998 to 2018, for eligible studies where patients were treated with re-irradiation for recurrent GBM. Outcomes of interest were 6 and 12-month overall survival (OS-6, OS-12), 6 and 12-month progression free survival (PFS-6, PFS-12) and serious (Grade 3 +) adverse events (AE). Read More

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December 2018

A Matched Analysis on the Prognostic Impact of Race on Survival Endpoints of Women with Early-Stage Endometrial Cancer.

Gynecol Obstet Invest 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan,

Objective: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis.

Methods And Materials: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. Read More

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December 2018

[Clinical results of combined intracavitary-interstitial image-guided adaptive brachytherapy in locally advanced cervical cancer].

Magy Onkol 2018 Dec 10;62(4):249-257. Epub 2018 Aug 10.

Onkológiai Tanszék, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary.

We present the early clinical results achieved with image-guided adaptive brachytherapy (IGABT) with combined intracavitary-interstitial (IC-IS) technique recently implemented in Hungary in the treatment of locally advanced cervical cancer (LACC). Twenty-one patients were treated with radio-chemotherapy (RCT) followed by combined IC-IS BT. At the end of the RCT we assessed the residual tumour with pelvic MRI. Read More

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December 2018

[Dosimetric evaluation of intracavitary-interstitial image-guided adaptive brachytherapy of cervical cancer and comparison with conventional treatment techniques].

Magy Onkol 2018 Dec 31;62(4):242-248. Epub 2018 Aug 31.

Onkológiai Tanszék, Semmelweis Egyetem, Általános Orvostudományi Kar, Budapest, Hungary.

Our aim was the dosimetric evaluation of intracavitary-interstitial high-dose-rate image-guided adaptive cervix brachytherapy, implemented in Hungary. Between 2016 and 2018, 21 patients with cervical cancer were treated with overall 72 fractions. Graphical optimized treatment plans were compared to inverse optimized plans, 3D optimized plans (without needles) and conventional intracavitary 2D plans. Read More

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December 2018

Pretreatment neutrophil to lymphocyte and platelet to lymphocyte ratios as predictive factors for the survival of cervical adenocarcinoma patients.

Cancer Manag Res 2018 22;10:6029-6038. Epub 2018 Nov 22.

Laboratory of Tumor Markers, Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw 02-781, Poland.

Objective: Our study assessed the clinical utility and prognostic value of pretreatment hematological parameters and calculated coefficients including the platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and monocyte to lymphocyte ratio (MLR) in patients with cervical adenocarcinoma (CA).

Materials And Methods: Among 738 cervical cancer patients with International Federation of Gynecology and Obstetrics (FIGO) stages IA-IV treated at our institution, 96 (13%) presented with CA histology. The blood samples, collected within 10 days before treatment, were analyzed using a Sysmex XN-2000 system. Read More

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November 2018

Intraoperative radiation therapy in uterine cervical cancer: A review.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):589-594. Epub 2018 Aug 10.

Radiation Oncology Department, Hospital Clinic of Barcelona, Spain.

Locally advanced uterine cervical cancer continues to present a high number of pelvic relapses. Intraoperative radiation therapy (IORT) allows a precise therapeutic intensification in the surgical area in cases in which removal of the tumour recurrence is feasible. At the same time, IORT excludes the radiosensitive organs from the field of irradiation. Read More

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What is the evidence for the clinical value of SBRT in cancer of the cervix?

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):574-579. Epub 2018 Oct 9.

Radiotherapy Dept., Fundación Arturo López Pérez, Santiago, Chile.

Aim: The aim of this review is to describe and analyze indications and results of the use of SBRT in uterine cervix cancer, reviewing articles published from January 2010 up to August 2017, for any one of the four indications listed:1Patient refusal or anatomic impediments to interstitial or intracavitary brachytherapy (BCT), i.e. SBRT as an "alternative" for BCT;2Patients with voluminous tumors, or asymmetric tumors where BCT alone would not achieve curative doses, i. Read More

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October 2018

Radiobiological considerations in combining doses from external beam radiotherapy and brachytherapy for cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):562-573. Epub 2018 Jul 2.

Unidad de Radiofísica, Hospital Universitario San Cecilio, E-18016 Granada, Spain.

The recommended radio-therapeutic treatment for cervix cancer consists of a first phase of external beam radiotherapy (EBRT) plus a second phase of brachytherapy (BT), the combined treatment being delivered within 8 weeks. In order to assess a comprehensive dosimetry of the whole treatment, it is necessary to take into account that these two phases are characterized by different spatial and temporal dosimetric distributions, which complicates the task of the summation of the two contributions, EBRT and BT. Radiobiology allows to tackle this issue pragmatically by means of the LQ model and, in fact, this is the usual tool currently in use for this matter. Read More

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July 2018
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Review of strategies for MRI based reconstruction of endocavitary and interstitial applicators in brachytherapy of cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):547-561. Epub 2018 Jul 23.

Hospital La Fe-IRIMED, Department of Radiation Oncology, Medical Physics Section, Valencia, Spain.

Brachytherapy plays an essential role in the curative intent management of locally advanced cervical cancer. The introduction of the magnetic resonance (MR) as a preferred image modality and the development of new type of applicators with interstitial components have further improved its benefits. The aim of this work is to review the current status of one important aspect in the cervix cancer brachytherapy procedure, namely catheter reconstruction. Read More

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The role of para-aortic nodal irradiation in cervical cancer.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):540-546. Epub 2018 Oct 9.

Department of Radiation Oncology, Médica Sur Hospital, México, DF, Mexico.

The current standard of care for locally advanced cervical cancer is whole pelvis and para-aortic radiation when indicated, delivered concomitantly with chemotherapy and brachytherapy. Para-aortic node involvement is a predictor of survival in locally advanced disease but presence of metastases is difficult to determine because the currently available imaging methods lack enough sensitivity to be able to detect accurately para-aortic metastases when surgical staging is not feasible. The objective of this review is to describe the current status of para-aortic lymph node irradiation in locally advanced cervical cancer. Read More

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October 2018

Image-guided brachytherapy in cervical cancer: Experience in the Complejo Hospitalario de Navarra.

Rep Pract Oncol Radiother 2018 Nov-Dec;23(6):510-516. Epub 2018 Oct 19.

Department of Radiation Oncology, Hospital de Navarra, Pamplona, Spain.

Purpose: To evaluate dosimetric and clinical findings of MRI-guided HDR brachytherapy (HDR-B) for cervical carcinoma.

Material And Methods: All patients had a CT, MRI and pelvic-paraaortic lymphadenectomy. Treatment: pelvic (+/-)para-aortic3D/IMRT radiotherapy (45 Gy), weekly cisplatin and HDR-B and pelvic node/parametrial boost 60 Gy until interstitial brachytherapy was done. Read More

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October 2018

The Utility of Endoscopic Ultrasound-Guided Brachytherapy in Liver Metastasis: A Case Report and Review of the Literature.

Am J Med Case Rep 2018 14;6(9):189-192. Epub 2018 Oct 14.

Division of Gastroenterology, Department of Medicine, State University of New York-Downstate Medical Center, Brooklyn, NY 11203.

Endoscopic ultrasound guided brachytherapy (EGBT) has been reported to be useful in certain malignancies including esophageal and pancreatic cancers. Percutaneous or surgical placement of radioactive seeds into the liver secondaries (brachytherapy) has been done successfully, however, the utility of EGBT in liver metastasis remains largely unclear. In this case report, we demonstrate the safety, efficacy and feasibility of EUS guided brachytherapy (EGBT) in liver metastasis secondary to leiomyosarcoma. Read More

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October 2018

Recent advances in gynecologic radiation oncology.

Curr Opin Obstet Gynecol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiation Oncology, University of California, Los Angeles, USA.

Purpose Of Review: Radiation has long been a primary treatment modality in locally advanced gynecologic carcinomas and a tool for palliation of metastatic disease. Here we review advances in imaging and radiation technologies and the corresponding clinical evolution of the role for radiation oncology in the treatment of gynecologic malignancies.

Recent Findings: Advances in MRI are impacting diagnosis, radiation target delineation, planning, treatment delivery, and response assessment. Read More

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December 2018

Development and dosimetric assessment of a patient-specific elastic skin applicator for high-dose-rate brachytherapy.

Brachytherapy 2018 Dec 6. Epub 2018 Dec 6.

Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea; Department of Radiation Oncology, Seoul National University Hospital, Seoul, Republic of Korea; Biomedical Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: The purpose of this study was to develop a patient-specific elastic skin applicator and to evaluate its dosimetric characteristics for high-dose-rate (HDR) brachytherapy.

Methods And Materials: We simulated the treatment of a nonmelanoma skin cancer on the nose. An elastic skin applicator was manufactured by pouring the Dragon Skin (Smooth-On Inc. Read More

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December 2018
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Subcutaneous spacer injection to reduce skin toxicity in breast brachytherapy: A pilot study on mastectomy specimens.

Brachytherapy 2018 Dec 5. Epub 2018 Dec 5.

Department of Surgery, Franciscus Gasthuis and Vlietland, Rotterdam, The Netherlands.

Purpose: Accelerated partial breast irradiation is a treatment option for selected patients with early-stage breast cancer. Some accelerated partial breast irradiation techniques lead to skin toxicity with the skin dose as a main risk factor. Biodegradable spacers are effective and safe in prostate brachytherapy to protect the rectum. Read More

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December 2018
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[CT-guidance interstitial Iodine-125 seed brachytherapy as a salvage therapy for recurrent head and neck carcinoma].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3686-3691

Department of Radiation Oncology, Peking University Third Hospital, Beijing 100191, China.

To investigate the efficacy of CT-guidance interstitial Iodine-125 seed brachytherapy as a salvage therapy for recurrent head and neck carcinoma. A total of 122 patients who had been treated for recurrent head and neck carcinoma with CT-guided Iodine-125 seed permanent implantation were conducted a retrospective analysis at Peking University Third Hospital from February 2003 to December 2015. The study included 78 male and 44 female patients. Read More

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December 2018

Dramatic polarization in genitourinary expert opinions regarding the clinical utility of positron emission tomography (PET) imaging in prostate cancer.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Objectives: To ascertain the opinions of North American genitourinary (GU) experts regarding inclusion of technologies such as prostate - specific membrane antigen (PSMA) and C - 11 choline positron emission tomography (PET) into routine practice.

Materials And Methods: A survey was distributed to North American GU experts. Questions pertained to the role of PSMA and C - 11 PET in PCa management. Read More

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October 2018
2 Reads

Chinese Expert Consensus Workshop Report: Guideline for permanent iodine-125 seed implantation of primary and metastatic lung tumors.

Thorac Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, China.

Surgery remains the first choice of cure for early stage lung cancer. However, many patients are diagnosed at advanced stage, and thus miss the opportunity to undergo surgery. As such patients derive limited benefits from chemotherapy or radiotherapy, alternatives focusing on local control have emerged, including iodine-125 seed implantation. Read More

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December 2018
2 Reads

Institutional patient accrual volume and the treatment quality of I‑125 prostate seed implantation in a Japanese nationwide prospective cohort study.

Strahlenther Onkol 2018 Dec 5. Epub 2018 Dec 5.

Japanese Foundation for Prostate Research, Tokyo, Japan.

Purpose: It is unclear whether experience at high-volume institute improves the treatment quality of prostate seed implantation. The aim of this study was to evaluate the effect of institutional experience on postimplant dosimetric parameters in a nationwide prospective cohort study.

Methods: From July 2005 to June 2007, 2354 patients were registered in the Japanese Prostate Cancer Outcome Study of Permanent I‑125 Seed Implantation (J-POPS), and 1126 patients treated with seed implantation alone were evaluated. Read More

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December 2018
2 Reads

Energy dependence of a radiophotoluminescent glass dosimeter for HDR Ir brachytherapy source.

Med Phys 2018 Dec 1. Epub 2018 Dec 1.

Department of Radiation Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Purpose: We determined correction factors for absorbed dose energy dependence and intrinsic energy dependence for measurements of absorbed dose to water around an Ir source using a radiophotoluminescent glass dosimeter (RPLD) calibrated with a 4-MV photon beam.

Methods: The ratio of the absorbed dose to the water and the average absorbed dose to RPLD for the Ir beam relative to the same ratio in a 4 MV photon beam defines the absorbed dose energy dependence and was determined at distances of 2-10 cm (at intervals of 1 cm) from the Ir source in a water phantom using the egs_chamber user code. The RPLD was calibrated to measure absorbed dose to water, D , in a 4 MV photon beam using an ionization chamber, which was also used to measure absorbed dose to water, D , in a water phantom using the Ir source. Read More

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December 2018

Dose to pelvic lymph nodes in image based high dose rate brachytherapy of carcinoma cervix.

Rep Pract Oncol Radiother 2019 Jan-Feb;24(1):80-85. Epub 2018 Nov 22.

Department of Radiation Oncology, Government Royapettah Hospital, India.

Aim: The aim of this study is to analyse the dosimetry to the pelvic lymph nodes and its correlation to point B using CT based high dose rate brachytherapy of carcinoma cervix.

Background: Conventionally, dose to pelvic lymph nodes from intracavitary brachytherapy was reported by point B and by the reference points of the lymphatic trapezoid.

Materials And Methods: 30 consecutive CT based high dose rate applications were reviewed between February and March 2016. Read More

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November 2018

Risk analysis of electronic intraoperative radiation therapy for breast cancer.

Brachytherapy 2018 Nov 29. Epub 2018 Nov 29.

UC San Diego Radiation Medicine and Applied Sciences, La Jolla, CA. Electronic address:

Purpose: To evaluate the process and improve safety of intraoperative radiation therapy (IORT) for early-stage breast cancers treated with electronic brachytherapy.

Methods And Materials: A multidisciplinary team conducted a failure mode and effects analysis (FMEA) for IORT breast cancer treatments by first developing a process map. This map was then used to identify failure modes for all steps in the treatment workflow. Read More

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November 2018

Individual 3-dimensional printed mold for treating hard palate carcinoma with brachytherapy: A clinical report.

J Prosthet Dent 2018 Nov 30. Epub 2018 Nov 30.

Professor, Radiation Oncology Unit, Department of Surgical and Biomedical Science, University of Perugia and Perugia General Hospital, Perugia, Italy.

This clinical report describes the use of a 3-dimensional (3D) printer to create an individual mold for delivering high-dose-rate interventional radiotherapy for hard palate cancer. The maxillary teeth and palate were scanned with an intraoral scanner (3Shape Trios 3). The scan was transformed into a mesh using the standard tessellation language (STL) format and aligned with Digital Imaging and Communications in Medicine (DICOM) computed tomography (CT) images using free Blue Sky Plan 4 planning software. Read More

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November 2018
5 Reads

Permanent I prostate brachytherapy for castration-resistant prostate cancer.

Int J Urol 2018 Dec 4. Epub 2018 Dec 4.

Department of Urology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China.

Objective: To evaluate the clinical significance of permanent I prostate brachytherapy in patients with castration-resistant prostate cancer.

Methods: A retrospective study of 45 patients with castration-resistant prostate cancer from the Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China was carried out. Patients were divided into two groups according to different treatments: 21 patients received endocrine therapy alone (control group), and 24 patients underwent brachytherapy combined with endocrine therapy (treatment group). Read More

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December 2018
1 Read

Let-7e enhances the radiosensitivity of colorectal cancer cells by directly targeting insulin-like growth factor 1 receptor.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Abnormal expression of various microRNAs (miRNAs), as regulators of biological signaling pathways, has a strong association with cancer resistance to chemotherapy and radiotherapy. The let-7 family of miRNAs as tumor suppressors have shown to be downregulated in different types of human malignancies including colorectal cancer (CRC). However, the biological function of let-7 members in the processes of resistance to radiation in CRC has not yet been completely elucidated. Read More

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December 2018

Radiosurgery or hypofractionated stereotactic radiotherapy after craniospinal irradiation in children and adults with medulloblastoma and ependymoma.

Childs Nerv Syst 2018 Dec 4. Epub 2018 Dec 4.

Department of Radiotherapy, The Maria Sklodowska-Curie Institute - Oncology Center, Gliwice Branch, Ul. Wybrzeże AK 15, 44-101, Gliwice, Poland.

Purpose: To assess the results and tolerance of radiosurgery/hypofractionated stereotactic radiotherapy performed after craniospinal irradiation for recurrent tumor.

Methods: Fourteen patients aged 3-46 years, diagnosed with medulloblastoma (10), anaplastic ependymoma (3), and primitive neuroectodermal tumor (1). All patients had craniospinal irradiation (CSI) with the total dose of 30. Read More

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December 2018
1 Read

[Accuracy of different image registration methods in image-guided adaptive brachytherapy for cervical cancer].

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1344-1348

School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.

Objective: To compare the accuracy of different methods for image registration in image-guided adaptive brachytherapy (IGABT) for cervical cancer.

Methods: The last treatment planning CT images (CT1) and the first treatment planning CT images (CT2) were acquired from 15 patients with cervical cancer and registered with different match image qualities (retained/removed catheter source in images) and different match regions [target only (S Group)/ interested organ structure (M Group)/body (L Group)] in Velocity3.2 software. Read More

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November 2018

Focal Salvage Treatment of Radiorecurrent Prostate Cancer: A Narrative Review of Current Strategies and Future Perspectives.

Cancers (Basel) 2018 Dec 3;10(12). Epub 2018 Dec 3.

Department of Radiotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Over the last decades, primary prostate cancer radiotherapy saw improving developments, such as more conformal dose administration and hypofractionated treatment regimens. Still, prostate cancer recurrences after whole-gland radiotherapy remain common, especially in patients with intermediate- to high-risk disease. The vast majority of these patients are treated palliatively with androgen deprivation therapy (ADT), which exposes them to harmful side-effects and is only effective for a limited amount of time. Read More

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December 2018
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Patient-reported sexual adjustment after definitive chemoradiation and MR-guided brachytherapy for cervical cancer.

Brachytherapy 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada; Radiation Medicine Program, University Health Network, Toronto, Ontario, Canada. Electronic address:

Purpose: The treatment of locally advanced cervical cancer with definitive chemoradiation (CRT) is associated with vaginal toxicity and altered sexual satisfaction. This prospective study assessed patient-reported sexual adjustment, vaginal dosimetry, and physician-reported vaginal toxicity in patients with cervical cancer treated with CRT and MR-guided brachytherapy (BT).

Materials And Methods: Between 2008 and 2010, International Federation of Gynecologists and Obstetricians stage IB-IVA patients with cervical cancer receiving definitive CRT were enrolled in a feasibility study assessing MR-guided BT. Read More

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November 2018
1 Read

Radiotherapy of prostate cancer in renal transplant recipients: single-center experience.

Neoplasma 2018 Sep 4. Epub 2018 Sep 4.

Department of Urology with Kidney Transplant Center, Comenius University Faculty of Medicine and University Hospital Bratislava, Bratislava, Slovakia.

This study analyzed the long-term outcomes of localized prostate cancer in renal transplant recipients after radiotherapy treatment - mainly brachytherapy. We retrospectively analyzed clinical data of renal transplant recipients between 2003 and 2016 at a single tertiary center, and identified four patients with high serum PSA level during regular follow-up, 1-108 months after primary renal transplantation. The mean age of patients with detected high serum PSA level with 9. Read More

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September 2018
4 Reads

[Unilateral multifocal uveal melanoma (a clinical and genetic study)].

Vestn Oftalmol 2018 ;134(5):78-85

Institute of General Pathology and Pathophysiology, 8 Baltiiskaya St., Moscow, Russian Federation, 125315.

The study presents clinical and genetic analysis of a case of unilateral multifocal uveal choroidal melanoma in a patient of 67 years. Results of ophthalmoscopy, echography, fluorescent angiography, optical coherence tomography are described. Molecular genetic testing of peripheral blood samples was performed, including detection of the occurrences of CC genotype in C3435T polymorphism of the gene ABCB1/MDR1 associated with unfavorable vital prognosis. Read More

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January 2018
3 Reads

The American Brachytherapy Society consensus statement for electronic brachytherapy.

Brachytherapy 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiation Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH. Electronic address:

Purpose: Brachytherapy is utilized in the treatment of many different malignancies; although traditionally performed with low-dose-rate or high-dose-rate techniques, more recently, electronic brachytherapy (EB) has emerged as a potential alternative. At this time, there are no evidence-based guidelines to assist clinicians in patient selection for EB and concerns exits regarding differences in dosimetry as compared to traditional brachytherapy techniques. As such, the American Brachytherapy Society appointed a group of physicians and physicists to create a consensus statement regarding the use of EB. Read More

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November 2018

Impact on treatment time of MRI-based brachytherapy in two implants (4 doses) compared with CT-based brachytherapy in five implants for cervical cancer.

Brachytherapy 2018 Nov 26. Epub 2018 Nov 26.

Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL. Electronic address:

Purpose: Concurrent chemoradiotherapy and brachytherapy is the standard of care for locally advanced cervical cancer. Brachytherapy is an integral part of treatment and has improved overall survival. Research is needed to ascertain the planning modalities and schedules to best use resources and optimize treatment time course. Read More

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November 2018
3 Reads

Dosimetric comparison of bladder, rectal, and vaginal surface doses between ovoids and cylinder-based vaginal brachytherapy in carcinoma of the endometrium.

J Cancer Res Ther 2018 Oct-Dec;14(6):1191-1195

Division of Radiation Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.

Purpose: The study aims to estimate the differences in vaginal surface, bladder, and rectal doses when adjuvant intracavitary brachytherapy is carried out with ovoids or with vaginal cylinders, in postoperative carcinoma endometrium and to assess the difference in variability in organs at risk (OAR) doses and thereby the reproducibility of application in subsequent sittings.

Materials And Methods: Fifteen patients each received vaginal brachytherapy with ovoid and cylindrical applicators. The dose received by 0. Read More

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November 2018
3 Reads

Radioablation by Image-Guided (HDR) Brachytherapy and Transarterial Chemoembolization in Hepatocellular Carcinoma: A Randomized Phase II Trial.

Cardiovasc Intervent Radiol 2018 Nov 28. Epub 2018 Nov 28.

Department of Radiology, Luwig-Maximilians-University Munich, Munich, Germany.

Background And Aims: The aim of this single-center, open-label phase II study was to assess the efficacy of image-guided high-dose-rate (HDR) brachytherapy (iBT) compared with conventional transarterial embolization (cTACE) in unresectable hepatocellular carcinoma.

Methods: Seventy-seven patients were treated after randomization to iBT or cTACE, as single or repeated interventions. Crossover was allowed if clinically indicated. Read More

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November 2018
1.965 Impact Factor

Comparison of two iodine-125 brachytherapy implant techniques for the treatment of lung tumor: Preplanning and intraoperative planning.

Brachytherapy 2018 Oct 25. Epub 2018 Oct 25.

Cancer Therapy and Research Center, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, PR China. Electronic address:

Purpose: To compare preplanning and intraoperative planning methods of lung tumor brachytherapy based on postimplant CT images and dosimetric outcomes.

Methods And Materials: Detailed postimplant evaluations of iodine-125 seed implants were performed in 15 patients using a preplanning technique and in 15 patients treated with an intraoperative planning technique. The implant details, dosimetric parameters, and implant quality indices were compared. Read More

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October 2018
1 Read

Radical dose escalation by high-dose-rate brachytherapy for localized prostate cancer-Significance of prostate-specific antigen nadir level within 18 months as correlation for long-term biochemical control.

Brachytherapy 2018 Oct 25. Epub 2018 Oct 25.

Christian-Albrechts-University Kiel, Medical Faculty, Kiel, Germany. Electronic address:

Purpose: High-dose-rate brachytherapy (HDR-BT) for dose escalation in localized prostate cancer has been established as one standard treatment option. However, long-term results at followup (FU) ≥5 years are usually needed to ensure robustness of reported outcomes. Potential benefit of salvage therapy is, nevertheless, higher when relapse is diagnosed early. Read More

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October 2018

Metal artifact reduction on cervical CT images by deep residual learning.

Biomed Eng Online 2018 Nov 27;17(1):175. Epub 2018 Nov 27.

School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, Guangdong, China.

Background: Cervical cancer is the fifth most common cancer among women, which is the third leading cause of cancer death in women worldwide. Brachytherapy is the most effective treatment for cervical cancer. For brachytherapy, computed tomography (CT) imaging is necessary since it conveys tissue density information which can be used for dose planning. Read More

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November 2018
2 Reads

A comparison of treatment outcome between fiducial-based and bone-based image guided radiotherapy in prostate cancer patients.

Radiat Oncol 2018 Nov 27;13(1):235. Epub 2018 Nov 27.

Radiotherapy Department, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Wybrzeze Armii Krajowej 15, 44-100, Gliwice, Poland.

Background And Purpose: To compare the clinical outcome in prostate cancer patients treated with radiotherapy using two forms of image guidance: bone-based (BB) or fiducial-based (FB).

Material And Methods: This retrospective study consisted of 180 patients treated with kV-kV image-guided radiotherapy (IGRT) between the years 2008 and 2011. A total of 89 patients were aligned to pelvic bone (Group BB) and 91 patients to the fiducial implanted into prostate for image guidance (Group FB). Read More

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November 2018

Dose coverage comparison between "interstitial catheter-only" and "hybrid intracavitary-interstitial brachytherapy" for early stage squamous cell carcinoma of the buccal mucosa.

J Contemp Brachytherapy 2018 Oct 31;10(5):486-491. Epub 2018 Oct 31.

Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.

Purpose: When squamous cell carcinoma of the buccal mucosa (BSCC) extends surrounding anatomical sites such as gingiva, retromolar triangle, or hard palate, it might be challenging to ensure adequate tumor coverage by sole interstitial brachytherapy due to the complexity of catheter implantation. By combining interstitial catheters with an enoral placed, individually assembled "oral spacer plus embedded catheters" device (hybrid of intracavitary-interstitial brachytherapy), it should be easier to deliver the necessary tumoricidal dose to irregular-shaped tumor volumes (clinical target volume - CTV) with improved conformity. The purpose of this analysis was to compare the dose distribution created by the hybrid of intracavitary-interstitial brachytherapy (HBT) with the dose distribution of an interstitial catheter only-approach, based on the interstitial catheters used for HBT (ISBT-only) by evaluating respective treatment plans (HBT plan vs. Read More

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October 2018

Transitional cell carcinoma of endometrium: a case report of rare pure form.

J Contemp Brachytherapy 2018 Oct 31;10(5):483-485. Epub 2018 Oct 31.

Radiotherapy Unit ARNAS-Civico Palermo.

Transitional cell carcinoma is a very rare histological subtype of endometrial cancer, with only 18 cases described in literature. Ovary represents the most common site where it accounts for 2% of all ovarian cancers. Due to the rarity of this disease, current management is controversial and includes various approaches, mostly described in the adjuvant setting, both radiotherapy and chemotherapy alone or in combination. Read More

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October 2018
6 Reads

An automated dose verification software for brachytherapy.

J Contemp Brachytherapy 2018 Oct 31;10(5):478-482. Epub 2018 Oct 31.

Key Laboratory of Radiation Physics and Technology, Institute of Nuclear Science and Technology, Sichuan University.

Purpose: To report an implementation method and the results of independent brachytherapy dose verification software (DVS).

Material And Methods: The DVS was developed based on Visual C++ and adopted a modular structure design. The DICOM RT files exported from a treatment planning system (TPS) were automatically loaded into the DVS. Read More

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October 2018