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    1179 results match your criteria Brachytherapy [Journal]

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    Focal boost to residual gross tumor volume in brachytherapy for cervical cancer-A feasibility study.
    Brachytherapy 2017 Nov 15. Epub 2017 Nov 15.
    Cancer Centre, Mount Vernon Hospital, Northwood, Middlesex, UK. Electronic address:
    Purpose: Image-guided plan optimization with MRI and CT for interstitial and intracavitary brachytherapy is an established technique in treating cervical cancer. The purpose of this study was to assess the feasibility of boosting the dose to the residual gross tumor volume (GTV-Tres) to 140% of the high-risk clinical target volume (HR-CTV) prescription.

    Methods And Materials: Brachytherapy plans from 50 consecutive patients were analyzed in this study. Read More

    Assessment of the implant geometry in fractionated interstitial HDR breast brachytherapy using an electromagnetic tracking system.
    Brachytherapy 2017 Nov 13. Epub 2017 Nov 13.
    Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany. Electronic address:
    Purpose: During the partial-breast treatment course by interstitial brachytherapy, electromagnetic tracking (EMT) was applied to measure the implant geometry. Implant-geometry variation, choice of reference data, and three registration methods were assessed.

    Methods And Materials: The implant geometry was measured in 28 patients after catheter implantation (EMTbed), during CT imaging (EMTCT), and in each of up to n = 9 treatment fractions (EMTF(k), k = 1, 2,… n). Read More

    Outcomes by molecular subtype after accelerated partial breast irradiation using single-entry catheters.
    Brachytherapy 2017 Nov 13. Epub 2017 Nov 13.
    Comprehensive Breast Center of Arizona, Phoenix, AZ.
    Purpose: Tumor biology is being recognized as an important indicator of prognosis and risk of locoregional recurrence. Here, we determine actuarial recurrence rates by approximated molecular subtype for women treated with single-entry catheter accelerated partial breast irradiation (sAPBI).

    Methods And Materials: One thousand four hundred eighty-six women with invasive cancer having known ER, PR, and Her2 status and at least 1-year of followup were treated using MammoSite, Contura, or SAVI sAPBI from 2002 to 2014 at our institution. Read More

    Pattern of relapse and dose received by the recurrent intraprostatic nodule in low- to intermediate-risk prostate cancer treated with single fraction 19 Gy high dose-rate brachytherapy.
    Brachytherapy 2017 Nov 11. Epub 2017 Nov 11.
    Sunnybrook Odette Cancer Centre, University of Toronto, Toronto, Ontario, Canada. Electronic address:
    Purpose: The purposes of this study were to investigate the pattern of relapse in patients with low- or intermediate-risk prostate cancer treated with 19-Gy high-dose-rate brachytherapy (HDR-BT) and to calculate the dose received by the area of recurrence.

    Methods And Materials: Patients included in this analysis were treated under a Phase II randomized trial that evaluated the role of 19-Gy HDR-BT monotherapy in low- and intermediate-risk prostate cancers. Multiparametric prostate MRI and prostate biopsy were performed in patients with suspicious local recurrence. Read More

    Clinical outcomes using image-guided interstitial brachytherapy for definitive cervical cancer patients with high-risk clinical target volumes greater than 30 cc.
    Brachytherapy 2017 Nov 8. Epub 2017 Nov 8.
    Cedars-Sinai Medical Center, Department of Radiation Oncology, Los Angeles, CA.
    Purpose: Given the limited data using an interstitial approach with 3D-based planning for definitive cervical cancer utilizing the GEC-ESTRO defined high-risk clinical target volume (HR-CTV), we reviewed our institutional experience of cervical cancer patients with HR-CTVs ≥ 30 cc to determine whether our clinical and toxicity outcomes are acceptable.

    Methods: A retrospective review of 37 cervical cancer patients with high-risk clinical target volumes (HR-CTVs) ≥30 cc treated with interstitial image-guided brachytherapy (IS IGBT) was performed. All patients received external beam radiotherapy to a median dose of 45 Gy, followed by IS IGBT delivered in a single implant to a median dose of 6 Gy × 5 fractions. Read More

    Interobserver variability in rectum contouring in high-dose-rate brachytherapy for prostate cancer: A multi-institutional prospective analysis.
    Brachytherapy 2017 Nov 4. Epub 2017 Nov 4.
    Department of Radiation Oncology, La Fe Polytechnic and University Hospital, Valencia, Spain; Medical Physics Research Group La Fe-UVEG, IRIMED, Valencia, Spain.
    Purpose: The aim of this study was to evaluate the interobserver variability (IOV) of rectum contouring, and its dosimetric consequences, for high-dose-rate brachytherapy in patients with prostate cancer across multiple institutions.

    Methods And Materials: Five radiation oncologists contoured rectums in 10 patients on transperineal ultrasound image sets after establishing a delineation consensus. The D0. Read More

    Experience of using MOSFET detectors for dose verification measurements in an end-to-end (192)Ir brachytherapy quality assurance system.
    Brachytherapy 2017 Oct 27. Epub 2017 Oct 27.
    Department of Medical Radiation Physics and Nuclear Medicine, Section for Radiotherapy Physics and Engineering, Karolinska University Hospital, Stockholm, Sweden; Department of Medical and Health Sciences and Center for Medical Image Science and Visualization, Radiation Physics, Linköping University, Linköping, Sweden.
    Purpose: Establishment of an end-to-end system for the brachytherapy (BT) dosimetric chain could be valuable in clinical quality assurance. Here, the development of such a system using MOSFET (metal oxide semiconductor field effect transistor) detectors and experience gained during 2 years of use are reported with focus on the performance of the MOSFET detectors.

    Methods And Materials: A bolus phantom was constructed with two implants, mimicking prostate and head & neck treatments, using steel needles and plastic catheters to guide the (192)Ir source and house the MOSFET detectors. Read More

    Physics aspects of the Papillon technique-Five decades later.
    Brachytherapy 2017 Nov 1. Epub 2017 Nov 1.
    Radiation Oncology Department, Jewish General Hospital, Montreal, Quebec, Canada; Medical Physics Unit, McGill University, Montreal, Quebec, Canada; Segal Cancer Centre, Jewish General Hospital, McGill University, Montréal, Québec, Canada. Electronic address:
    Purpose: The Papillon technique using 50-kVp soft X-rays to treat rectal adenocarcinomas was developed and clinically implemented in the 1960s. We describe differences between accurate dosimetry and clinical implementation of this technique that is extending from its very inception to date.

    Methods And Materials: A renaissance of the Papillon technique occurred with two recently introduced 50-kVp systems: Papillon+ by Ariane and a custom-made rectal applicator (consisting of a surface applicator inserted into a proctoscope) by iCAD's Xoft Axxent Electronic Brachytherapy (eBT) System (iCad, Inc. Read More

    Clinical outcomes with MRI-guided image-based brachytherapy in cervical cancer: An institutional experience.
    Brachytherapy 2017 Nov 1. Epub 2017 Nov 1.
    Department of Radiotherapy and Oncology and Regional Cancer Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Purpose: To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer.

    Methods And Materials: Sixty patients of cervical cancer were treated with external radiotherapy 46 Gy in 23 fractions with weekly cisplatin and MRI-guided BT 7 Gy × 4 fractions with a minimum dose of 85.7 Gy (EQD2) to the high-risk clinical target volume (HRCTV). Read More

    The role of (125)I interstitial brachytherapy for inoperable parotid gland carcinoma.
    Brachytherapy 2017 Nov 1. Epub 2017 Nov 1.
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, P.R. China. Electronic address:
    Purpose: The treatment of inoperable parotid gland carcinoma is challenging and controversial. The purpose of this paper was to present our experience in treating this malignancy using (125)I interstitial brachytherapy.

    Methods And Materials: Thirteen patients with advanced carcinomas of the parotid gland were included and treated with (125)I interstitial brachytherapy in Peking University School and Hospital of Stomatology from January 2003 to December 2015. Read More

    Manual vs. automated implantation of seeds in prostate brachytherapy: Oncologic results from a single-center study.
    Brachytherapy 2017 Nov 1. Epub 2017 Nov 1.
    Department of Radiation Oncology, Institut Bergonié, Comprehensive Cancer Center, Bordeaux Cedex, France.
    Purpose: The objective of this study was to study survival and tolerance of prostate cancer patients treated with (125)I permanent interstitial brachytherapy by automated vs. manual implantation of seeds.

    Methods And Materials: Between 2002 and 2010, 349 selected patients were treated with (125)I brachytherapy by the same team: from 2002 to April 2005, 65 patients with linked seeds and then 284 patients treated using Nucletron First System automated implantation. Read More

    3T multiparametric MRI-guided high-dose-rate combined intracavitary and interstitial adaptive brachytherapy for the treatment of cervical cancer with a novel split-ring applicator.
    Brachytherapy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Radiation Oncology, Seidman Cancer Center, University Hospitals, Cleveland Medical Center, Cleveland, OH.
    Purpose: To evaluate the role of 3T-MRI-guided adaptive high-dose-rate (HDR) combined intracavitary and interstitial brachytherapy for cervical cancer using a novel intracavitary split-ring (ICSR) applicator adapter.

    Methods And Materials: We retrospectively reviewed all HDR brachytherapy cases from 2013 to 2015 using an ICSR applicator. Initial optimization was performed using 3T multiparametric MRI (mpMRI) series with an applicator in place. Read More

    Impact of radiotherapy modalities on outcomes in the adjuvant management of uterine carcinosarcoma: A National Cancer Database analysis.
    Brachytherapy 2017 Oct 30. Epub 2017 Oct 30.
    Department of Radiation Oncology, University of Colorado Denver, Aurora, CO.
    Purpose: In the postoperative management of uterine carcinosarcoma (UCS), the roles of individual radiotherapy (RT) modalities, chiefly external-beam radiotherapy (EBRT) and brachytherapy (BT), remain undefined. We analyzed the survival impact of EBRT and BT using the National Cancer Database.

    Methods And Materials: We abstracted women diagnosed with UCS from 2004 to 2012 who received hysterectomy and had complete RT information. Read More

    Early outcomes and impact of a hybrid IC/IS applicator for a new MRI-based cervical brachytherapy program.
    Brachytherapy 2017 Oct 28. Epub 2017 Oct 28.
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL.
    Purpose: The purpose of this study was to report early outcomes and assess the learning curve in a new MRI-based cervical brachytherapy program.

    Methods: We accrued 33 patients prospectively, and only patients with ≥3 months' followup (n = 27) were assessed for disease control and toxicity. Eras were defined as first half and second half for the intracavitary (IC)-only era (n = 13 each), and the intracavitary/interstitial (IC/IS) era was separated by difference in applicator availability (n = 7). Read More

    Long-term evaluation of urinary, sexual, and quality of life outcomes after brachytherapy for penile carcinoma.
    Brachytherapy 2017 Oct 28. Epub 2017 Oct 28.
    Radiotherapy Department, Gustave Roussy Cancer Campus, Villejuif, France; INSERM, U1030, Villejuif, France; Université Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, France; Institut de Recherche Biomédicale des Armées, Brétigny sur Orge, France; French Military Health Service Academy, Ecole du Val-de-Grace, Paris, France.
    Purpose: Brachytherapy (BT) is an effective organ-preserving treatment for selected localized penile carcinoma, providing high local control rates. Long-term functional results however, are still insufficiently evaluated.

    Methods And Materials: All consecutive patients treated with low-dose-rate or pulse-dose-rate BT in our institute for a localized penile cancer and who were in first complete remission and followed for at least 3 years were included. Read More

    Long-term outcomes of APBI via multicatheter interstitial HDR brachytherapy: Results of a prospective single-institutional registry.
    Brachytherapy 2017 Oct 28. Epub 2017 Oct 28.
    Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO. Electronic address:
    Purpose: Long-term outcome reports of accelerated partial-breast irradiation (APBI) are limited. Here, we report the 10-year outcomes of APBI delivered using multicatheter interstitial implant (ISI) brachytherapy.

    Methods And Materials: Patients with early-stage breast cancer treated with APBI via ISI brachytherapy were enrolled in a prospective registry. Read More

    The American Brachytherapy Society consensus statement for accelerated partial-breast irradiation.
    Brachytherapy 2017 Oct 23. Epub 2017 Oct 23.
    Department of Radiation Oncology, Tufts University School of Medicine, Boston, MA; Department of Radiation Oncology, Brown University, Providence, RI.
    Purpose: Adjuvant radiation after breast-conserving surgery remains the standard-of-care treatment for patients with ductal carcinoma in situ and early-stage invasive breast cancer. Multiple alternatives to standard whole-breast irradiation exist including accelerated partial-breast irradiation (APBI). Therefore, the purpose of this APBI guideline is to provide updated data for clinicians as well as recommendations regarding appropriate patient selection and techniques to deliver APBI. Read More

    Delineating the relationship between Point A prescription dose and pelvic lymph node doses in intracavitary high-dose-rate brachytherapy treatment of cervical cancer for use in low- and middle-income countries.
    Brachytherapy 2017 Oct 21. Epub 2017 Oct 21.
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL. Electronic address:
    Purpose: To define the relationship between the Point A prescription dose and the dose delivered to various pelvic lymph node groups during high-dose-rate (HDR) brachytherapy treatment of cervical cancer. In less developed countries, brachytherapy is often done without three-dimensional image guidance, instead relying on plain radiography and prescription to Point A. A defined relationship between Point A dose and lymph node doses would help physicians in these health care settings to more accurately estimate nodal doses. Read More

    A prospective phase I comparison of toxicity and cosmesis outcomes of single-fraction IORT and hypofractionated radiotherapy with IORT boost in early-stage breast cancer.
    Brachytherapy 2017 Nov - Dec;16(6):1232-1238.e2. Epub 2017 Oct 9.
    The Center for Cancer Prevention and Treatment at St. Joseph Hospital, Orange, CA. Electronic address:
    Purpose: Radiation therapy is proven to reduce local recurrence in patients with early-stage breast cancer. To reduce toxicity, treatment time, and improve accuracy, intraoperative radiation therapy was used as definitive treatment or as a boost. The study's objective was to compare the short-term toxicity and cosmesis of single-fraction (SF) IORT and hypofractionated radiotherapy with IORT boost (HfB) given as definitive treatment. Read More

    High-intermediate prostate cancer treated with low-dose-rate brachytherapy with or without androgen deprivation therapy.
    Brachytherapy 2017 Nov - Dec;16(6):1101-1105. Epub 2017 Oct 12.
    Radiation Program, BC Cancer Agency, and Department of Radiotherapy and Developmental Radiotherapeutics, University of British Columbia, Vancouver, Canada.
    Purpose: To describe outcomes of men with unfavorable (high-tier) intermediate risk prostate cancer (H-IR) treated with low-dose-rate (LDR) brachytherapy, with or without 6 months of androgen deprivation therapy (ADT).

    Methods And Materials: Patients with H-IR prostate cancer, treated before 2012 with LDR brachytherapy without external radiation are included. Baseline tumor characteristics are described. Read More

    Evaluation of interfractional variation of organs and displacement of catheters during high-dose-rate interstitial brachytherapy for gynecologic malignancies.
    Brachytherapy 2017 Nov - Dec;16(6):1192-1198. Epub 2017 Oct 6.
    Department of Radiation Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH; Department of Radiation Oncology, Case Western Reserve University, University Hospitals Seidman Cancer Center, Cleveland, OH.
    Purpose: To investigate the dosimetric effects due to interfractional changes in catheter position and variation in patient's anatomy during the course of interstitial high-dose-rate (HDR) brachytherapy.

    Methods And Materials: A total of 15 patients with either cervical or vaginal cancer underwent interstitial HDR brachytherapy. Interstitial catheters and fiducials were placed under fluoroscopy and intraoperative 3T MRI to confirm the desired catheter placement for adequate target volume coverage. Read More

    American College of Radiology-American Brachytherapy Society practice parameter for electronically generated low-energy radiation sources.
    Brachytherapy 2017 Nov - Dec;16(6):1083-1090. Epub 2017 Oct 5.
    Dartmouth-Hitchcock Medical Center, Lebanon, NH.
    Background: This collaborative practice parameter technical standard has been created between the American College of Radiology and American Brachytherapy Society to guide the usage of electronically generated low energy radiation sources (ELSs). It refers to the use of electronic X-ray sources with peak voltages up to 120 kVp to deliver therapeutic radiation therapy.

    Main Findings: The parameter provides a guideline for utilizing ELS, including patient selection and consent, treatment planning, and delivery processes. Read More

    The validity of Acuros BV and TG-43 for high-dose-rate brachytherapy superficial mold treatments.
    Brachytherapy 2017 Nov - Dec;16(6):1280-1288. Epub 2017 Sep 28.
    Blood & Cancer Centre, Wellington Hospital, Wellington, NZ.
    Purpose: The purpose of this work is to validate the Acuros BV dose calculation algorithm for high-dose-rate (HDR) brachytherapy superficial mold treatments in the absence of full scatter conditions and compare this with TG-43 dose calculations. We also investigate the impact of additional back scatter material (bolus) applied above surface molds to the dose distributions under the mold.

    Methods And Materials: The absorbed dose at various depths was compared for simulations performed using either TG-43 or Acuros BV dose calculations. Read More

    Benefit of adaptive CT-based treatment planning in high-dose-rate endorectal brachytherapy for rectal cancer.
    Brachytherapy 2017 Sep 26. Epub 2017 Sep 26.
    Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.
    Purpose: In this planning study, we investigated the dosimetric benefit of repeat CT-based treatment planning at each fraction vs. the use of a single CT-based treatment plan for all fractions for high-dose-rate endorectal brachytherapy (HDREBT) for rectal cancer.

    Methods And Materials: We included 11 patients that received a CT scan with applicator in situ for all three fractions. Read More

    Patterns of care and outcomes of proton and eye plaque brachytherapy for uveal melanoma: Review of the National Cancer Database.
    Brachytherapy 2017 Nov - Dec;16(6):1225-1231. Epub 2017 Sep 28.
    Department of Radiation Oncology, Barnes-Jewish Hospital, St. Louis, MO. Electronic address:
    Purpose: To examine national practice patterns and outcomes of eye plaque brachytherapy compared to proton external beam radiotherapy in the treatment of choroid melanoma.

    Methods And Materials: Demographic and clinical data for 1224 patients with choroid melanoma treated with either brachytherapy or proton beam therapy from 2004 to 2013 were obtained from the National Cancer Database. Logistic regression and propensity score matching was used to create a 1:1 matched cohort. Read More

    Semiconductor real-time quality assurance dosimetry in brachytherapy.
    Brachytherapy 2017 Sep 27. Epub 2017 Sep 27.
    Centre for Medical Radiation Physics, University of Wollongong, Wollongong, Australia. Electronic address:
    With the increase in complexity of brachytherapy treatments, there has been a demand for the development of sophisticated devices for delivery verification. The Centre for Medical Radiation Physics (CMRP), University of Wollongong, has demonstrated the applicability of semiconductor devices to provide cost-effective real-time quality assurance for a wide range of brachytherapy treatment modalities. Semiconductor devices have shown great promise to the future of pretreatment and in vivo quality assurance in a wide range of brachytherapy treatments, from high-dose-rate (HDR) prostate procedures to eye plaque treatments. Read More

    Image-guided high-dose-rate intracavitary brachytherapy in the treatment of medically inoperable early-stage endometrioid type endometrial adenocarcinoma.
    Brachytherapy 2017 Nov - Dec;16(6):1144-1151. Epub 2017 Sep 22.
    Lewis Katz School of Medicine at Temple University, Philadelphia, PA.
    Purpose: The purpose of this case series is to describe the treatment and outcomes of a cohort of patients with inoperable early-stage endometrioid endometrial cancer with 3D image-guided high-dose-rate (HDR) intracavitary brachytherapy.

    Materials And Methods: A review was performed of patients with early-stage endometrial cancer who underwent primary radiation treatment between 2010 and 2016. Staging and treatment planning were performed CT, pelvic ultrasound, and pelvic MRI. Read More

    An integrated system for clinical treatment verification of HDR prostate brachytherapy combining source tracking with pretreatment imaging.
    Brachytherapy 2017 Sep 22. Epub 2017 Sep 22.
    School of Science, RMIT University, Melbourne, VIC, Australia.
    Purpose: High-dose-rate (HDR) prostate brachytherapy treatment is usually delivered in one or a few large dose fractions. Poor execution of a planned treatment could have significant clinical impact, as high doses are delivered in seconds, and mistakes in an individual fraction cannot be easily rectified. Given that most potential errors in HDR brachytherapy ultimately lead to a geographical miss, a more direct approach to verification of correct treatment delivery is to directly monitor the position of the source throughout the treatment. Read More

    Time-resolved in vivo dosimetry for source tracking in brachytherapy.
    Brachytherapy 2017 Sep 21. Epub 2017 Sep 21.
    Department of Oncology, Aarhus University Hospital, Aarhus C, Denmark.
    Purpose: The purpose of this article is to demonstrate that brachytherapy source tracking can be realized with in vivo dosimetry. This concept could enable real-time treatment monitoring.

    Methods: In vivo dosimetry was incorporated in the clinical routine during high-dose-rate prostate brachytherapy at Aarhus University Hospital. Read More

    Patterns of care and impact of brachytherapy boost utilization for squamous cell carcinoma of the base of tongue in a large, national cohort.
    Brachytherapy 2017 Nov - Dec;16(6):1205-1212. Epub 2017 Sep 22.
    Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, NY; Department of Veterans Affairs, New York Harbor Healthcare System, Brooklyn, NY.
    Purpose: The National Cancer Data Base was analyzed to evaluate the patterns of care and impact of brachytherapy (BT) boost on overall survival (OS) for patients with squamous cell carcinoma of the base of tongue.

    Methods And Materials: Patients with nonmetastatic squamous cell carcinoma of the base of tongue between 2004 and 2012 who received concurrent external beam radiation therapy (EBRT) and chemotherapy with or without BT boost in the definitive setting were queried. Overall survival was assessed by the Kaplan-Meier method. Read More

    Needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer evaluated by repeated MRI.
    Brachytherapy 2017 Sep 18. Epub 2017 Sep 18.
    Department of Oncology, Aarhus University Hospital, Aarhus, Denmark.
    Purpose: To quantify needle migration and dosimetric impact in high-dose-rate brachytherapy for prostate cancer and propose a threshold for needle migration.

    Methods And Materials: Twenty-four high-risk prostate cancer patients treated with an HDR boost of 2 × 8.5 Gy were included. Read More

    Radioactive seed migration following parotid gland interstitial brachytherapy.
    Brachytherapy 2017 Nov - Dec;16(6):1219-1224. Epub 2017 Sep 15.
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, P.R. China. Electronic address:
    Purpose: To evaluate the incidence and associated factors of pulmonary seed migration after parotid brachytherapy using a novel migrated seed detection technique.

    Methods And Materials: Patients diagnosed with parotid cancer who underwent permanent parotid brachytherapy from January 2006 to December 2011 were reviewed retrospectively. Head and neck CT scans and chest X-rays were evaluated during routine follow-up. Read More

    American Brachytherapy Society recurrent carcinoma of the endometrium task force patterns of care and review of the literature.
    Brachytherapy 2017 Nov - Dec;16(6):1129-1143. Epub 2017 Sep 6.
    Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX.
    Purpose: The purpose of this American Brachytherapy Society task force is to present a literature review and patterns of care by a panel of experts for the management of vaginal recurrence of endometrial cancer.

    Methods And Materials: In 2016, the American Brachytherapy Society Board selected a panel of experts in gynecologic brachytherapy to update our current state of knowledge for managing vaginal recurrence of endometrial cancer. Practice patterns were evaluated via an online survey and clinical updates occurred through a combination of literature review and clinical experience and/or expertise. Read More

    Efficiency of using the day-of-implant CT for planning of SAVI APBI.
    Brachytherapy 2017 Aug 28. Epub 2017 Aug 28.
    Department of Radiation Oncology, Washington University in St. Louis, St. Louis, MO.
    Purpose: The purpose of the study was to develop an optimized, efficient workflow for using the day-of-implant (DOI) CT for treatment planning of accelerated partial breast irradiation brachytherapy using the strut-adjusted volume implant (SAVI) device.

    Methods And Materials: For 62 consecutive SAVI patients, a DOI CT was acquired and used for treatment planning. A "verification" CT was acquired 24-72 h after implant and immediately before the first fraction, then registered to the DOI CT. Read More

    A novel urethral sparing technique for high-dose-rate prostate brachytherapy after transurethral resection of the prostate.
    Brachytherapy 2017 Nov - Dec;16(6):1113-1118. Epub 2017 Aug 30.
    Department of Radiation Oncology, University of California San Francisco, San Francisco, CA. Electronic address:
    Purpose: The purpose of this study was to assess retrospectively the variability of the urethral dose optimized using a Foley catheter versus urethral contrast injected using a new modified triple-lumen catheter, in CT-based high-dose-rate (HDR) prostate brachytherapy of posttransurethral resection of prostate (TURP) patients.

    Methods And Materials: At our institution, there were six post-TURP patients with prostate carcinoma between July 2014 and April 2016 who underwent transperineal interstitial HDR brachytherapy (16 needles). A custom modified triple-lumen catheter was placed to inject contrast into the TURP defect. Read More

    Total reference air kerma can accurately predict isodose surface volumes in cervix cancer brachytherapy. A multicenter study.
    Brachytherapy 2017 Nov - Dec;16(6):1184-1191. Epub 2017 Sep 1.
    Department of Oncology, Aarhus University Hospital Aarhus, Denmark.
    Purpose: To demonstrate that V60 Gy, V75 Gy, and V85 Gy isodose surface volumes can be accurately estimated from total reference air kerma (TRAK) in cervix cancer MRI-guided brachytherapy (BT).

    Methods And Materials: 60 Gy, 75 Gy, and 85 Gy isodose surface volumes levels were obtained from treatment planning systems (VTPS) for 239 EMBRACE study patients from five institutions treated with various dose rates, fractionation schedules and applicators. An equation for estimating VTPS from TRAK was derived. Read More

    Low-dose-rate prostate brachytherapy: 4-8 week postimplant prostate-specific antigen a novel predictor of biochemical failure-free survival.
    Brachytherapy 2017 Nov - Dec;16(6):1119-1128. Epub 2017 Aug 24.
    Department of Radiation Oncology, Pennington Cancer Center, Baton Rouge, LA.
    Purpose: The purpose of this study was to determine the relationship between patient, disease, and treatment variables and biochemical failure-free survival (bFFS) following low-dose-rate prostate brachytherapy (LDR-BT).

    Methods And Materials: Data from 624 consecutive patients who received LDR-BT for localized prostate cancer between 2002 and 2012 at a single institution were collected for various patient, disease, and treatment characteristics including a 4-8 week postimplant PSA (4-8wkPSA). Subgroup analysis was stratified by risk category and treatment regimen. Read More

    Clinical implementation of a novel Double-Balloon single-entry breast brachytherapy applicator.
    Brachytherapy 2017 Nov - Dec;16(6):1239-1245. Epub 2017 Aug 24.
    Department of Human Oncology, University of Wisconsin, Madison, WI.
    Purpose: The purpose of the study was to describe the clinical utilization of a novel Double-Balloon applicator for accelerated partial breast irradiation (APBI).

    Methods And Materials: The Double-Balloon single-entry breast applicator contains a single central treatment catheter, as well as four peripheral catheters that can be differentially loaded to customize radiation dose coverage. An inner balloon is filled with up to 7-30 cm(3) of saline to increase separation between the peripheral catheters, and an outer balloon is filled with up to 37-115 cm(3) of saline to displace breast tissue from the peripheral catheters. Read More

    Brachytherapy attains abscopal effects when combined with immunostimulatory monoclonal antibodies.
    Brachytherapy 2017 Nov - Dec;16(6):1246-1251. Epub 2017 Aug 21.
    Division of Immunology and Immunotherapy, Center for Applied Medical Research (CIMA), University of Navarra and Instituto de Investigacion Sanitaria de Navarra (IdISNA), Pamplona, Spain; Department of Oncology, University Clinic of Navarra, Pamplona, Spain; University Clinic, University of Navarra and Instituto de Investigacion Sanitaria de Navarra (IdISNA), Pamplona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Spain. Electronic address:
    Purpose/objectives: Preclinical and clinical evidence indicate that the proimmune effects of radiotherapy can be synergistically augmented with immunostimulatory monoclonal antibodies (mAb) to act both on irradiated tumor lesions and on tumors at distant, nonirradiated sites. We have recently reported that external beam radiotherapy achieves abscopal effects when combined with antagonist anti-PD1 mAbs and agonist anti-CD137 (4-1BB) mAbs. The goal of this work is to study the abscopal effects of radiotherapy instigated by brachytherapy techniques. Read More

    Salvage brachytherapy for recurrent prostate cancer after definitive radiation therapy: A comparison of low-dose-rate and high-dose-rate brachytherapy and the importance of prostate-specific antigen doubling time.
    Brachytherapy 2017 Nov - Dec;16(6):1091-1098. Epub 2017 Aug 21.
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
    Background: Salvage brachytherapy is a treatment option for patients with locally recurrent prostate cancer after primary radiation therapy. We reviewed our experience using low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy to compare the outcome and toxicity profiles of each approach in the salvage brachytherapy setting.

    Methods And Materials: Ninety-eight patients with biopsy-proven locally recurrent prostate cancer who underwent salvage brachytherapy (LDR = 37; HDR = 61) following an initial course of definitive radiotherapy between 4/2003 and 4/2015 were retrospectively reviewed. Read More

    Failure modes and effects analysis for ocular brachytherapy.
    Brachytherapy 2017 Nov - Dec;16(6):1265-1279. Epub 2017 Aug 18.
    Department of Radiation Oncology, The University of Arizona, Tucson, AZ.
    Purpose: The aim of the study was to identify potential failure modes (FMs) having a high risk and to improve our current quality management (QM) program in Collaborative Ocular Melanoma Study (COMS) ocular brachytherapy by undertaking a failure modes and effects analysis (FMEA) and a fault tree analysis (FTA).

    Methods And Materials: Process mapping and FMEA were performed for COMS ocular brachytherapy. For all FMs identified in FMEA, risk priority numbers (RPNs) were determined by assigning and multiplying occurrence, severity, and lack of detectability values, each ranging from 1 to 10. Read More

    Intraoperative implantation of a mesh of directional palladium sources (CivaSheet): Dosimetry verification, clinical commissioning, dose specification, and preliminary experience.
    Brachytherapy 2017 Nov - Dec;16(6):1257-1264. Epub 2017 Aug 18.
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
    Purpose: To present the clinical commissioning of a novel (103)Pd directional brachytherapy device (CivaSheet) for intraoperative radiation therapy.

    Methods And Materials: Clinical commissioning for the CivaSheet consisted of establishing: (1) source strength calibration capabilities, (2) experimental verification of TG-43 dosimetry parameters, (3) treatment planning system validation, and (4) departmental practice for dose specification and source ordering. Experimental verification was performed in water with radiochromic film calibrated with a 37 kVp X-ray beam. Read More

    MR- versus CT-based high-dose-rate interstitial brachytherapy for vaginal recurrence of endometrial cancer.
    Brachytherapy 2017 Nov - Dec;16(6):1159-1168. Epub 2017 Aug 17.
    Department of Radiation Oncology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, MD. Electronic address:
    Purpose: To compare clinical outcomes of MR-based versus CT-based high-dose-rate interstitial brachytherapy (ISBT) for vaginal recurrence of endometrioid endometrial cancer (EC).

    Methods And Materials: We reviewed 66 patients with vaginal recurrent EC; 18 had MR-based ISBT on a prospective clinical trial and 48 had CT-based treatment. Kaplan-Meier survival modeling was used to generate estimates for local control (LC), disease-free interval (DFI), and overall survival (OS), and multivariate Cox modeling was used to assess prognostic factors. Read More

    Association of bladder dose with late urinary side effects in cervical cancer high-dose-rate brachytherapy.
    Brachytherapy 2017 Nov - Dec;16(6):1175-1183. Epub 2017 Aug 17.
    British Columbia Cancer Agency, Vancouver Centre, Vancouver, BC, Canada.
    Purpose: The purpose of this work was to study the association between specific urinary sequelae and locally accumulated dose to the bladder wall and bladder neck in the treatment of cervical cancer with multifraction high-dose-rate (HDR) brachytherapy.

    Methods And Materials: A cohort of 60 cervical cancer patients, treated with both external beam and five HDR brachytherapy insertions between 2008 and 2014 at the BC Cancer Agency, was identified. The accumulated dose received over five brachytherapy sessions was evaluated for the bladder wall and bladder neck of each patient using dosimetric parameters calculated from deformably registered image data sets. Read More

    MRI-based treatment planning and dose delivery verification for intraocular melanoma brachytherapy.
    Brachytherapy 2017 Aug 14. Epub 2017 Aug 14.
    Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO.
    Purpose: Episcleral plaque brachytherapy (EPB) planning is conventionally based on approximations of the implant geometry with no volumetric imaging following plaque implantation. We have developed an MRI-based technique for EPB treatment planning and dose delivery verification based on the actual patient-specific geometry.

    Methods And Materials: MR images of 6 patients, prescribed 85 Gy over 96 hours from Collaborative Ocular Melanoma Study-based EPB, were acquired before and after implantation. Read More

    High-dose-rate interstitial brachytherapy boost in inoperable locally advanced tongue carcinoma.
    Brachytherapy 2017 Nov - Dec;16(6):1213-1218. Epub 2017 Aug 12.
    Department of Radiation Oncology, Fundación Instituto Valenciano de Oncología (IVO), Valencia, Spain.
    Purpose: Locally advanced tongue carcinomas (LATCs) in inoperable lesions are managed with external beam radiation therapy (EBRT) and chemotherapy. In our institution, the boost to the gross tumor volume is delivered with high-dose-rate brachytherapy (HDR-BT) after EBRT. We review the outcome of these patients when HDR-BT is added as a boost. Read More

    Dosimetric analysis and preliminary clinical result of image-guided brachytherapy with or without hybrid technique for cervical cancer using VariSource titanium ring applicator with "Siriraj Ring Cap".
    Brachytherapy 2017 Nov - Dec;16(6):1199-1204. Epub 2017 Aug 12.
    Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Purpose: Titanium ring cap applicator (VariSource) was applied in treating cervical cancer patients by using image-guided brachytherapy (IGBT). However, its sizes appeared to be relatively large for most of our patients. Thus, we have developed a specific applicator "Siriraj Ring Cap," which is slightly smaller and more suitable for our patients. Read More

    Pretreatment 3T multiparametric MRI staging predicts for biochemical failure in high-risk prostate cancer treated with combination high-dose-rate brachytherapy and external beam radiotherapy.
    Brachytherapy 2017 Nov - Dec;16(6):1106-1112. Epub 2017 Aug 12.
    Department of Radiation Oncology, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA.
    Purpose: To determine whether pretreatment 3T multiparametric MRI (mpMRI) staging impacts biochemical recurrence-free survival (BRFS) or distant metastasis-free survival (DMFS) for men with high-risk prostate cancer treated with combination high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT).

    Materials And Methods: This institutional review board-approved retrospective study included a cohort of 37 men with high-risk prostate cancer treated with HDR brachytherapy and EBRT after 3T mpMRI. Kaplan-Meier analysis was used to evaluate whether mpMRI evidence of extracapsular extension or seminal vesicle invasion (SVI) resulted in differences in BRFS or DMFS. Read More


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