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    1247 results match your criteria Brachytherapy [Journal]

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    Second primary malignancies after high-dose-rate Co photon or Cf neutron brachytherapy in conjunction with external-beam radiotherapy for endometrial cancer.
    Brachytherapy 2018 Jun 9. Epub 2018 Jun 9.
    Department of Radiation Oncology, Warren Alpert Medical School of Brown University, Providence, RI.
    Purpose: Second primary malignancies (SPMs) may occur in organs after radiotherapy (RT). This study aimed to determine the rate and distribution of SPMs for photon- or neutron-emitting radiotherapy sources for patients treated for primary endometrial cancer.

    Methods And Materials: The cohort comprised 426 patients with 5334 patient-years of observation. Read More

    Parallel imaging compressed sensing for accelerated imaging and improved signal-to-noise ratio in MRI-based postimplant dosimetry of prostate brachytherapy.
    Brachytherapy 2018 Jun 4. Epub 2018 Jun 4.
    Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
    Purpose: To investigate the feasibility of using parallel imaging compressed sensing (PICS) to reduce scan time and improve signal-to-noise ratio (SNR) in MRI-based postimplant dosimetry of prostate brachytherapy.

    Methods And Materials: Ten patients underwent low-dose-rate prostate brachytherapy with radioactive seeds stranded with positive magnetic resonance-signal seed markers and were scanned on a Siemens 1.5T Aera. Read More

    Real-time Doppler ultrasound to identify vessels and guide needle placement for gynecologic interstitial brachytherapy.
    Brachytherapy 2018 May 31. Epub 2018 May 31.
    Department of Radiation, John Muir Health, Walnut Creek, CA.
    Purpose: Doppler ultrasound (US) gives real-time information regarding anatomy and blood vessel location to guide needle placement for gynecologic interstitial (IS) brachytherapy (BT). We retrospectively assessed Doppler US images for vessel quantity, size, and distribution in cervical cancer patients undergoing high-dose-rate BT at our institution.

    Methods And Materials: Eleven consecutive patients undergoing IS high-dose-rate BT implants for cervical cancer between 2015 and 2017 were included. Read More

    Workflow and efficiency in MRI-based high-dose-rate brachytherapy for cervical cancer in a high-volume brachytherapy center.
    Brachytherapy 2018 May 26. Epub 2018 May 26.
    Department of Radiation Oncology, Magee-Womens Hospital, UPMC Hillman Cancer Center, Pittsburgh, PA.
    Purpose: We report the clinical workflow and time required for MRI-based image-guided brachytherapy (MR-IGBT) of cervical cancer patients in a high-volume brachytherapy center with 10 years of experiences to provide a practical guideline for implementing MR-IGBT into clinical use.

    Methods And Materials: We recorded the time and workflow of each procedure step within the 40 consecutive ring and tandem applicator fractions of MR-IGBT by our multidisciplinary team. We divided the entire procedure into four sections based on where the procedure was performed: (1) applicator insertion under sedation, (2) MR imaging, (3) planning, and (4) treatment delivery. Read More

    Comparison of spinal and general anesthesia approaches for MRI-guided brachytherapy for cervical cancer.
    Brachytherapy 2018 May 25. Epub 2018 May 25.
    Department of Radiation Oncology, University of Cincinnati Medical Center, Cincinnati, OH. Electronic address:
    Purpose: To evaluate the impact of general versus spinal anesthesia on postprocedure narcotic use and of extradepartmental planning MRI on treatment time in high-dose-rate brachytherapy for cervical cancer.

    Methods And Materials: Twenty-five patients (10 general anesthesia and 15 spinal anesthesia) who collectively received 96 brachytherapy fractions (39 general and 57 spinal) for cervical cancer between February 2015 and April 2017 were retrospectively reviewed. Over this time, institutional practice shifted from operating room-based general anesthesia to intradepartmental spinal anesthesia for tandem and ring placement. Read More

    Perioperative high-dose-rate brachytherapy in locally advanced and recurrent gynecological cancer: Final results of a Phase II trial.
    Brachytherapy 2018 May 23. Epub 2018 May 23.
    Department of Gynecology and Obstaetrics, Clínica Universitaria de Navarra, Pamplona, Navarre, Spain.
    Purpose: To determine the long-term results of a Phase II trial of perioperative high-dose-rate brachytherapy (PHDRB) in primary advanced or recurrent gynecological cancer.

    Methods And Materials: Fifty patients with locally advanced and recurrent gynecological cancer suitable for salvage surgery were included. Unirradiated patients (n = 25) received preoperative chemoradiation followed by surgery and PHDRB (16-24 Gy). Read More

    A quality assurance device for measuring afterloader performance and transit dose for nasobiliary high-dose-rate brachytherapy.
    Brachytherapy 2018 May 17. Epub 2018 May 17.
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN.
    Purpose: Nasobiliary high-dose-rate (HDR) brachytherapy has emerged as an effective tool to boost the radiation dose for patients with unresectable perihilar cholangiocarcinoma. This work describes a quality assurance (QA) tool for measuring the HDR afterloader's performance, including the transit dose, when the source wire travels through a tortuous nasobiliary catheter path.

    Methods And Materials: The nasobiliary QA device was designed to mimic the anatomical path of a nasobiliary catheter, including the nasal, stomach, duodenum, and bile duct loops. Read More

    Technique for the administration of high-dose-rate brachytherapy to the bile duct using a nasobiliary catheter.
    Brachytherapy 2018 May 16. Epub 2018 May 16.
    Department of Radiation Oncology, Mayo Clinic, Rochester, MN.
    Purpose: Cholangiocarcinoma patients who are potential candidates for liver transplantation may be treated with high-dose-rate (HDR) brachytherapy using a minimally invasive nasobiliary catheter in an effort to escalate the radiotherapy dose to the tumor and maximize local control rates. This work describes the equipment, procedures, and quality assurance (QA) that enables successful administration.

    Methods And Materials: This work describes the nasobiliary catheter placement, simulation, treatment planning, treatment delivery, and QA. Read More

    Novel use of ViewRay MRI guidance for high-dose-rate brachytherapy in the treatment of cervical cancer.
    Brachytherapy 2018 May 14. Epub 2018 May 14.
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Carbone Comprehensive Cancer Center, Madison, WI. Electronic address:
    Purpose: To characterize image quality and feasibility of using ViewRay MRI (VR)-guided brachytherapy planning for cervical cancer.

    Methods And Materials: Cervical cancer patients receiving intracavitary brachytherapy with tandem and ovoids, planned using 0.35T VR MRI at our institution, were included in this series. Read More

    Improving the treatment planning and delivery process of Xoft electronic skin brachytherapy.
    Brachytherapy 2018 May 14. Epub 2018 May 14.
    Department of Radiation Medicine and Applied Sciences, UC San Diego, Chula Vista, CA. Electronic address:
    Purpose: To develop an improved Xoft electronic skin brachytherapy process and identify areas of further improvement.

    Methods And Materials: A multidisciplinary team conducted a failure modes and effects analysis (FMEA) by developing a process map and a corresponding list of failure modes. The failure modes were scored for their occurrence, severity, and detectability, and a risk priority number (RPN) was calculated for each failure mode as the product of occurrence, severity, and detectability. Read More

    Comparison of computed tomography with magnetic resonance imaging for imaging-based clinical target volume contours in cervical cancer brachytherapy.
    Brachytherapy 2018 May 12. Epub 2018 May 12.
    Department of Medical Physics, The Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
    Purpose: To compare CT- and MRI-based brachytherapy (BT) target volumes for patients with advanced cervical cancer so as to identify those who benefit most from MRI-based planning. We also studied how the natural mobility of the organ at risks (OARs) affects the given doses.

    Methods And Materials: Subjects were 60 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage IB-IVA cervical cancer. Read More

    Comparison of dosimetric and clinical outcomes between short- and long-channel cylinder applicators for vaginal brachytherapy in intermediate- and high-risk endometrial cancer.
    Brachytherapy 2018 May 11. Epub 2018 May 11.
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL. Electronic address:
    Purpose: Vaginal brachytherapy (VBT) using a cylinder applicator is a standard treatment of intermediate- and high-risk endometrial cancer. We conducted a retrospective study of the dosimetric and clinical outcomes at our institution with 2 single-channel applicators in patients receiving VBT.

    Methods And Materials: One hundred thirty-six patients with endometrial cancer treated from 2006 to 2016 receiving VBT after definitive surgery were evaluated. Read More

    A novel applicator design for intracavitary brachytherapy of the nasopharynx: Simulated reconstruction, image-guided adaptive brachytherapy planning, and dosimetry.
    Brachytherapy 2018 May 11. Epub 2018 May 11.
    Head and Neck Unit, Department of Radiation Oncology, University of Santo Tomas Hospital, Benavides Cancer Institute, Manila, Philippines; Department of Radiological Sciences, Faculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines.
    Purpose: In nasopharyngeal cancer, brachytherapy is given as boost in primary treatment or as salvage for recurrent or persistent disease. The Rotterdam nasopharyngeal applicator (RNA) allows for suboptimal reduction of soft palate radiation dose, based on image-guided brachytherapy plans. Building on the RNA, we propose a novel design, the Benavides nasopharyngeal applicator (BNA). Read More

    Malignant obstructive jaundice treated with intraluminal placement of Iodine-125 seed strands and metal stents: An analysis of long-term outcomes and prognostic features.
    Brachytherapy 2018 May 7. Epub 2018 May 7.
    Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institution of Medical Imaging, Shanghai, China.
    Purpose: The purpose of this study was to analyze the long-term outcomes, including safety, efficacy, and prognostic features, of intraluminal brachytherapy with Iodine-125 (I) seed strand and stent placement for treatment of patients with malignant obstructive jaundice (MOJ).

    Methods And Materials: From January 2009 to December 2013, 107 consecutive patients with MOJ were treated with intraluminal placement of I seed strands and metal stents. A retrospective evaluation of therapeutic outcomes, including overall survival (OS), stent patency rate, complications, and prognostic features, was conducted in 101 patients. Read More

    Iodine-125 seed brachytherapy inhibits non-small cell lung cancer by suppressing epithelial-mesenchymal transition.
    Brachytherapy 2018 Apr 30. Epub 2018 Apr 30.
    Department of Medical Imaging, Second Hospital of Tianjin Medical University, Tianjin, China. Electronic address:
    Purpose: Metastatic non-small cell lung cancer (NSCLC) has posed a great clinical challenge with high mortality. Iodine-125 (I-125) seed brachytherapy has not been widely applied in clinic against NSCLC.

    Methods And Materials: Mice were injected with human H23 NSCLC cells to establish a mouse xenograft model, which received I-125 seed implantation. Read More

    Proficiency-based cervical cancer brachytherapy training.
    Brachytherapy 2018 Apr 25. Epub 2018 Apr 25.
    Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA. Electronic address:
    Purpose: Although brachytherapy increases the local control rate for cervical cancer, there has been a progressive decline in its use. Furthermore, the training among residency programs for gynecologic brachytherapy varies considerably, with some residents receiving little to no training. This trend is especially concerning given the association between poor applicator placement and decline in local control. Read More

    The role of radiation therapy in the treatment of Stage II endometrial cancer: A large database study.
    Brachytherapy 2018 Apr 21. Epub 2018 Apr 21.
    Department of Radiation Oncology, University of Wisconsin Hospital and Clinics, Madison, WI.
    Purpose: The optimum adjuvant treatment for Stage II endometrial cancer patients is unknown. External beam radiation therapy (EBRT) is often considered the standard of care; however, retrospective series suggest that brachytherapy (BT) alone may be sufficient for selected patients. As randomized data are lacking, we used a large database to explore this question. Read More

    Moving toward uniform and evidence-based practice of radiotherapy for management of cervical cancer in Ontario, Canada.
    Brachytherapy 2018 Apr 19. Epub 2018 Apr 19.
    Juravinski Cancer Center, Hamilton, ON, Canada; Radiation Oncology, Department of Oncology, McMaster University, Hamilton, ON, Canada. Electronic address:
    Purpose: To recognize the practice of radiotherapy for management of cervical cancer in Ontario, Canada, and to use the results of the survey to harmonize and standardize practice across the province.

    Methods And Materials: An electronic survey (SurveyMonkey) was sent to all 14 provincial cancer centers by Cancer Care Ontario Gynecology Community of Practice (CoP) in 2013. The survey included 72 questions in four different categories: general/demographic, pretreatment assessment, external beam radiotherapy (EBRT), and brachytherapy (BT). Read More

    Interventional Radiation Oncology (IRO): Transition of a magnetic resonance simulator to a brachytherapy suite.
    Brachytherapy 2018 May - Jun;17(3):587-596. Epub 2018 Mar 13.
    Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, MD. Electronic address:
    Purpose: As a core component of a new gynecologic cancer radiation program, we envisioned, structured, and implemented a novel Interventional Radiation Oncology (IRO) unit and magnetic resonance (MR)-brachytherapy environment in an existing MR simulator.

    Methods And Materials: We describe the external and internal processes required over a 6-8 month time frame to develop a clinical and research program for gynecologic brachytherapy and to successfully convert an MR simulator into an IRO unit.

    Results: Support of the institution and department resulted in conversion of an MR simulator to a procedural suite. Read More

    New approach of ultra-focal brachytherapy for low- and intermediate-risk prostate cancer with custom-linked I-125 seeds: A feasibility study of optimal dose coverage.
    Brachytherapy 2018 May - Jun;17(3):544-555. Epub 2018 Mar 7.
    Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse - Oncopôle, Department of Engineering and Medical Physics, Toulouse, France.
    Purpose: To present the feasibility study of optimal dose coverage in ultra-focal brachytherapy (UFB) with multiparametric MRI for low- and intermediate-risk prostate cancer.

    Methods And Materials: UFB provisional dose plans for small target volumes (<7 cc) were calculated on a prostate training phantom to optimize the seeds number and strength. Clinical UFB consisted in a contour-based nonrigid registration (MRI/Ultrasound) to implant a fiducial marker at the location of the tumor focus. Read More

    A new delivery system to resolve dosimetric issues in intravascular brachytherapy.
    Brachytherapy 2018 May - Jun;17(3):634-643. Epub 2018 Mar 5.
    Medical Physics Unit, Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
    Purpose: Renewed interest is being expressed in intravascular brachytherapy (IVBT). A number of unresolved issues exist in the discipline. Providing a homogeneous and adequate dose to the target remains difficult in IVBT. Read More

    Time-driven activity-based cost comparison of prostate cancer brachytherapy and intensity-modulated radiation therapy.
    Brachytherapy 2018 May - Jun;17(3):556-563. Epub 2018 Mar 5.
    Department of Radiation Oncology, University of Virginia School of Medicine, Charlottesville. Electronic address:
    Purpose: To evaluate the delivery cost of frequently used radiotherapy options offered to patients with intermediate- to high-risk prostate cancer using time-driven activity-based costing and compare the results with Medicare reimbursement and relative value units (RVUs).

    Methods And Materials: Process maps were created to represent each step of prostate radiotherapy treatment at our institution. Salary data, equipment purchase costs, and consumable costs were factored into the cost analysis. Read More

    Endoluminal high-dose-rate brachytherapy for locally recurrent or persistent esophageal cancer.
    Brachytherapy 2018 May - Jun;17(3):621-627. Epub 2018 Feb 26.
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:
    Purpose: Management of locally recurrent or persistent esophageal cancer (EC) after standard chemoradiation is challenging. This study updates our experience of treating medically inoperable EC patients with endoluminal high-dose-rate brachytherapy (EHDRBT) including the patients treated with a novel multiballoon channel centering esophageal applicator.

    Methods And Materials: Thirty-three consecutive patients with early-stage primary (n = 7), posttreatment persistent (n = 7), and recurrent (n = 19) EC treated with EHDRBT at our institution were included. Read More

    Appropriate timing for postimplant imaging in permanent breast seed implant: Results from a serial CT study.
    Brachytherapy 2018 May - Jun;17(3):609-614. Epub 2018 Feb 26.
    Department of Physics & Astronomy, University of Calgary, Calgary, AB, Canada; Department of Medical Physics, Tom Baker Cancer Centre, Calgary, AB, Canada; Department of Oncology, University of Calgary, Calgary, AB, Canada.
    Purpose: Postimplant analysis in permanent breast seed implant (PBSI) is performed at inconsistent times subsequent to seed implantation across cancer centers, creating challenges in the interpretation of dosimetric data and ultimately the correlation with clinical outcomes. The purpose of this study is to determine the most appropriate time postimplant to perform this analysis.

    Methods And Materials: Nine patients treated at our institution with PBSI were included in this analysis. Read More

    Quality of life up to 10 years after external beam radiotherapy and/or brachytherapy for prostate cancer.
    Brachytherapy 2018 May - Jun;17(3):517-523. Epub 2018 Feb 26.
    Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany; Department of Radiation Oncology, MediClin Robert Janker Klinik, Bonn, Germany. Electronic address:
    Purpose: The aim of this study was to evaluate quality-of-life changes up to 10 years following three different radiotherapy concepts.

    Methods And Materials: In the years 2000-2003, 295 patients were treated with external beam radiotherapy (EBRT; n = 135; 70.2 Gy in 1. Read More

    Early toxicity and health-related quality of life results of high-dose-rate brachytherapy as monotherapy for low and intermediate-risk prostate cancer.
    Brachytherapy 2018 May - Jun;17(3):524-529. Epub 2018 Feb 23.
    Division of Radiation Oncology, The Ottawa Hospital, Ottawa, Ontario, Canada; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
    Purpose: To determine the acute toxicity and effect on health-related quality of life of a two-fraction regimen of high-dose-rate (HDR) prostate brachytherapy.

    Methods And Materials: Patients with low- or intermediate-risk prostate cancer were treated with HDR brachytherapy as monotherapy in two implants of 13.5 Gy spaced 7-14 days apart. Read More

    Image-guided adaptive brachytherapy in primary vaginal cancers: A monocentric experience.
    Brachytherapy 2018 May - Jun;17(3):571-579. Epub 2018 Feb 6.
    Department of Radiation Oncology, Gustave Roussy, University Paris Saclay, Villejuif, France; Molecular Radiotherapy-UMR 1030, Gustave Roussy, Villejuif, France.
    Purpose: Primary vaginal cancer is a rare disease for which treatment has been modeled based on cervical cancer. We report our experience in the use of image-guided adaptive brachytherapy (IGABT) in this indication.

    Methods And Materials: Patients treated for vaginal cancer with a combination of external beam radiation therapy and IGABT were identified through electronic search. Read More

    Single-institutional outcomes of adjuvant brachytherapy for Stage I endometrial cancer-Are outcomes consistent with randomized studies?
    Brachytherapy 2018 May - Jun;17(3):564-570. Epub 2018 Feb 14.
    Department of Radiation Oncology, University of Pittsburgh Hillman Cancer Center, Pittsburgh, PA. Electronic address:
    Purpose: Vaginal brachytherapy (VBT) alone has been shown to be a viable adjuvant treatment strategy for most patients with Stage I endometrioid endometrial cancer. We sought to examine our institutional data following practice pattern changes resulting from the publications of GOG-99 and PORTEC-2.

    Methods And Materials: We retrospectively analyzed women who underwent adjuvant VBT after surgical staging for Stage 1 endometrioid endometrial cancer at our institution from 2007 to 2014. Read More

    Improving dose delivery by adding interstitial catheters to fixed geometry applicators in high-dose-rate brachytherapy for cervical cancer.
    Brachytherapy 2018 May - Jun;17(3):580-586. Epub 2018 Feb 14.
    St Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, England; Department of Oncology, University of Surrey, Guildford, England.
    Purpose: Image-guided brachytherapy (IGBT) is an essential component of the treatment of locally advanced cervical cancer. Interstitial (IS) catheters are being increasingly used for bulkier tumors. We have retrospectively assessed the dosimetric impact of IS catheters. Read More

    Technique adaptation, strategic replanning, and team learning during implementation of MR-guided brachytherapy for cervical cancer.
    Brachytherapy 2018 Jan - Feb;17(1):86-93
    Radiation Medicine Program, University Health Network and Princess Margaret Cancer Centre, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada. Electronic address:
    Purpose: MR-guided brachytherapy (MRgBT) with interstitial needles is associated with improved outcomes in cervical cancer patients. However, there are implementation barriers, including magnetic resonance (MR) access, practitioner familiarity/comfort, and efficiency. This study explores a graded MRgBT implementation strategy that included the adaptive use of needles, strategic use of MR imaging/planning, and team learning. Read More

    Comparison of chronological changes in urinary function in patients who underwent low-dose-rate brachytherapy for prostate cancer-A randomized controlled trial of alpha-1 adrenoceptor antagonist alone versus combination with cyclooxygenase-2 inhibitor.
    Brachytherapy 2018 May - Jun;17(3):537-543. Epub 2018 May 7.
    Department of Urology, Nara Medical University, Kashihara, Nara, Japan.
    Purpose: To evaluate the add-on efficacy of a cyclooxygenase (COX)-2 inhibitor on the chronological changes in urinary function in patients who underwent low-dose-rate prostate brachytherapy.

    Methods And Materials: A total of 310 patients with prostate cancer who underwent low-dose-rate-brachytherapy were enrolled. Patients were randomized and allocated to the monotherapy group (tamsulosin alone: 0. Read More

    A Phase II trial of 8 weeks of degarelix for prostate volume reduction: Efficacy and hormonal recovery.
    Brachytherapy 2018 May - Jun;17(3):530-536. Epub 2018 Feb 2.
    British Columbia Cancer Agency, Center for the Southern Interior, Kelowna, British Columbia, Canada.
    Purpose: The purpose of this study was to determine the efficacy of 8 weeks of degarelix for prostate downsizing before interstitial brachytherapy. We also report associated toxicity and the time course of endocrine recovery over the following 12 months.

    Methods And Materials: Fifty patients were accrued to an open-label Phase II clinical trial (www. Read More

    Custom mold applicator high-dose-rate brachytherapy for nonmelanoma skin cancer-An analysis of 273 lesions.
    Brachytherapy 2018 May - Jun;17(3):601-608. Epub 2018 Feb 15.
    Department of Radiation Oncology, Baylor Scott & White Health, Temple, TX; Department of Radiation Oncology, University of Arizona College of Medicine Phoenix, Tucson, AZ.
    Purpose: Nonmelanoma skin cancer is the most commonly diagnosed malignancy in the United States. A modern version of surface brachytherapy, "topographic applicator brachytherapy" (TAB), can be used to treat early-stage nonmelanoma skin cancer (ES-NMSC). The purpose of this study was to evaluate the acute toxicity, chronic toxicity, and recurrence rates of patients with ES-NMSC treated with TAB. Read More

    Demonstration of simulated annealing optimization for permanent breast seed implant treatment planning.
    Brachytherapy 2018 May - Jun;17(3):615-620. Epub 2018 Feb 1.
    Department of Medical Physics, Tom Baker Cancer Centre, Calgary, AB, Canada; Department of Physics & Astronomy, University of Calgary, Calgary, AB, Canada; Department of Oncology, University of Calgary, Calgary, AB, Canada; Okolo Health Inc., Calgary, AB, Canada.
    Purpose: Permanent breast seed implant (PBSI) is a developing brachytherapy technique for the treatment of early-stage breast cancer. In current practice, PBSI uses manual planning strategies to generate clinical treatment plans. In this work, a simulated annealing-based algorithm is developed to demonstrate the first application of inverse optimization for PBSI. Read More

    Assessment of a source position checking tool for the quality assurance of transfer tubes used in HDR Ir brachytherapy treatments.
    Brachytherapy 2018 May - Jun;17(3):628-633. Epub 2018 Jan 17.
    The Medical Physics Department, The James Cook University Hospital, Middlesbrough, UK; The Department of Medical Physics and Clinical Engineering, Royal Berkshire NHS Foundation Trust, Reading, UK. Electronic address:
    Purpose: The determination of source positions before treatment is an essential part of the quality assurance (QA) associated with high dose rate brachytherapy treatments. The purpose of this study was to design and commission a tool to allow the quantification of source positions across multiple transfer tube types.

    Methods And Materials: A bespoke flexi-adapter jig, three transfer tube adapters, and a film piercing pointer were designed and built for source position QA across three transfer tube types-the standard, 6 French, and gynae transfer tubes. Read More

    Validation of MRI to TRUS registration for high-dose-rate prostate brachytherapy.
    Brachytherapy 2018 Mar - Apr;17(2):283-290. Epub 2018 Jan 10.
    Département de radio-oncologie, CHUM, Montréal, Québec, Canada; CRCHUM, Université de Montréal, Montréal, Québec, Canada; TECHNA Institute, Toronto, Ontario, Canada. Electronic address:
    Purpose: The objective of this study was to develop and validate an open-source module for MRI to transrectal ultrasound (TRUS) registration to support tumor-targeted prostate brachytherapy.

    Methods And Materials: In this study, 15 patients with prostate cancer lesions visible on multiparametric MRI were selected for the validation. T2-weighted images with 1-mm isotropic voxel size and diffusion weighted images were acquired on a 1. Read More

    A Medicare cost analysis of MRI- versus CT-based high-dose-rate brachytherapy of the cervix: Can MRI-based planning be less costly?
    Brachytherapy 2018 Mar - Apr;17(2):326-333. Epub 2018 Jan 10.
    Department of Radiation Oncology, Stritch School of Medicine, Loyola University Chicago, Chicago, IL. Electronic address:
    Purpose: While some institutions deliver multiple fractions per implant for MRI-based planning, it is common for only one fraction to be delivered per implant with CT-based cervical brachytherapy. The purpose of this study was to compare physician costs, hospital costs, and overall costs for cervical cancer patients treated with either CT-based or MRI-based high-dose-rate (HDR) cervical brachytherapy to determine if MRI-based brachytherapy as described can be financially feasible.

    Methods And Materials: We identified 40 consecutive patients treated with curative intent cervical brachytherapy. Read More

    Deformable image registration-based contour propagation yields clinically acceptable plans for MRI-based cervical cancer brachytherapy planning.
    Brachytherapy 2018 Mar - Apr;17(2):360-367. Epub 2018 Jan 10.
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI.
    Purpose: To study the dosimetric impact of deformable image registration-based contour propagation on MRI-based cervical cancer brachytherapy planning.

    Methods And Materials: High-risk clinical target volume (HRCTV) and organ-at-risk (OAR) contours were delineated on MR images of 10 patients who underwent ring and tandem brachytherapy. A second set of contours were propagated using a commercially available deformable registration algorithm. Read More

    Comments on "Low-dose-rate prostate brachytherapy: 4-8 week postimplant prostate-specific antigen a novel predictor of biochemical failure-free survival".
    Brachytherapy 2018 Mar - Apr;17(2):514-515. Epub 2018 Jan 10.
    Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran. Electronic address:

    A comparison of early prostate-specific antigen decline between prostate brachytherapy and different fractionation of external beam radiation-Impact on biochemical failure.
    Brachytherapy 2018 Mar - Apr;17(2):277-282. Epub 2018 Jan 3.
    Department of Radiation Oncology, Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, Montréal, Canada; CRCHUM-Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Canada.
    Purpose: The aim of this study was to compare early prostate-specific antigen (PSA) decline patterns and PSA nadirs between low-dose-rate seed prostate brachytherapy (LDR-PB) and different fractionations of external beam radiotherapy (EBRT) and their predictive importance for biochemical failure (bF).

    Methods And Materials: Patients with D'Amico low- or intermediate-risk prostate cancer who underwent a single-modality treatment without androgen deprivation were included in this study. Three different treatment groups were compared: (1) normofractionation EBRT up to 70. Read More

    Efficacy and the toxicity of the interstitial high-dose-rate brachytherapy in the management of recurrent keloids: 5-year outcomes.
    Brachytherapy 2018 May - Jun;17(3):597-600. Epub 2018 Jan 2.
    Department of Reconstructive Surgery, University Clinic Schleswig-Holstein, Campus Kiel, Kiel, Germany.
    Purpose: Recurring keloids are a clinical challenge. Interdisciplinary treatments are required in most cases. Owing to the wide variety of concepts, the optimal treatment regime remains unclear. Read More

    Image-guided interstitial high-dose-rate brachytherapy for locally recurrent uterine cervical cancer: A single-institution study.
    Brachytherapy 2018 Mar - Apr;17(2):368-376. Epub 2017 Dec 21.
    Department of Radiation Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.
    Purpose: The aim of this study was to investigate the efficacy and safety of image-guided high-dose-rate (HDR) interstitial brachytherapy (ISBT) for reirradiation of locally recurrent uterine cervical cancer.

    Methods And Materials: Between 2008 and 2015, patients receiving reirradiation using HDR-ISBT for local gross recurrence of uterine cervical cancer after definitive or postoperative radiotherapy were analyzed retrospectively. The prescription doses per fraction ranged 2. Read More

    Ruthenium brachytherapy for uveal melanomas: Factors affecting the development of radiation complications.
    Brachytherapy 2018 Mar - Apr;17(2):432-438. Epub 2017 Dec 21.
    Ocular Oncology Unit, Department of Ophthalmology, Fondazione Policlinico Universitario "A. Gemelli", Università Cattolica del Sacro Cuore, Rome, Italy.
    Purpose: To investigate how treatment complications are related to dosimetric parameters after ruthenium-106 brachytherapy for uveal melanoma, in a large, clinically homogeneous population.

    Methods And Materials: A retrospective review was performed to evaluate patients affected by small and medium size uveal melanoma, treated with ruthenium-106 brachytherapy from December 2006 to December 2014. We excluded tumors with posterior margin within 1 mm from the edge of the optic disc and foveola. Read More

    Efficacy and safety of iodine-125 radioactive seeds brachytherapy for advanced non-small cell lung cancer-A meta-analysis.
    Brachytherapy 2018 Mar - Apr;17(2):439-448. Epub 2017 Dec 21.
    Department of Epidemiology, School of Public Health, Shandong University, Jinan, Shandong, China. Electronic address:
    Purpose: This meta-analysis was conducted to investigate the efficacy and safety of I brachytherapy for locally advanced non-small cell lung cancer (NSCLC).

    Methods And Materials: Trials comparing I brachytherapy with chemotherapy in NSCLC were identified. Meta-analysis was performed to obtain pooled risk ratios for an overall response rate (ORR), disease control rate (DCR) and complications, and pooled hazard ratio for overall survival (OS). Read More

    Cost-effectiveness of adjuvant intravaginal brachytherapy in high-intermediate risk endometrial carcinoma.
    Brachytherapy 2018 Mar - Apr;17(2):399-406. Epub 2017 Dec 21.
    Department of Radiation Oncology, University of Vermont Medical Center, Burlington, VT. Electronic address:
    Purpose: We assessed the cost-effectiveness of adjuvant intravaginal brachytherapy (IVBT) vs. observation after total hysterectomy and bilateral salpingo-oophorectomy (TH/BSO) for high-intermediate risk (HIR) endometrial carcinoma.

    Methods And Materials: A Markov model was used to assess the cost-effectiveness of IVBT by comparing average cumulative costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) between patients allocated to (1) 'observation' or (2) 'IVBT' after TH/BSO. Read More

    Patient-reported health-related quality of life for men treated with low-dose-rate prostate brachytherapy as monotherapy with 125-iodine, 103-palladium, or 131-cesium: Results of a prospective phase II study.
    Brachytherapy 2018 Mar - Apr;17(2):265-276. Epub 2017 Dec 18.
    Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:
    Purpose: To compare quality of life (QoL) after brachytherapy with one of the three approved radioactive isotopes.

    Methods And Materials: Patients with mostly favorable intermediate-risk prostate cancer were treated on this prospective phase II trial with brachytherapy as monotherapy, without hormonal therapy. QoL was recorded at baseline and each follow-up by using the Expanded Prostate Cancer Index Composite instrument. Read More

    Accelerated partial breast irradiation for suitable elderly women using a single fraction of multicatheter interstitial high-dose-rate brachytherapy: Early results of the Single-Fraction Elderly Breast Irradiation (SiFEBI) Phase I/II trial.
    Brachytherapy 2018 Mar - Apr;17(2):407-414. Epub 2017 Dec 15.
    Department of Radiation Oncology, Antoine Lacassagne Cancer Center, University of Cote d'Azur, Nice, France.
    Purpose/objective: To evaluate feasibility and early clinical outcomes of a single fraction of multi-catheter interstitial high-dose rate brachytherapy for accelerated partial breast irradiation (APBI) in the elderly.

    Material/methods: From November 2012 to September 2014, 26 patients (≥70) with early breast cancer were enrolled in a prospective phase II trial (NCT01727011). After lumpectomy, intra-operative catheter implant was performed for post-operative APBI (single fraction 16 Gy). Read More

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